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4. Diagnostic Yield of Chromosomal Microarray Analysis in Fetuses With Isolated Increased Nuchal Translucency: A French Multicenter Study

Author

Egloff, M., Hervé, B., Quibel, T., Jaillard, S., Le Bouar, G., Uguen, K., Saliou, A.-H., Valduga, M., Perdriolle, E., Coutton, C., Coston, A.-L., Coussement, A., Anselem, O., Missirian, C., Bretelle, F., Prieur, F., Fanget, C., Muti, C., Jacquemot, M.-C., Beneteau, C., Le Vaillant, C., Vekemans, M., Salomon, L. J., Vialard, F., and Malan, V.

Published
2019
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7. Live well, die well - an international cohort study on experiences, concerns and preferences of patients in the last phase of life: the research protocol of the iLIVE study

Author

Yildiz, B, Allan, S, Bakan, M, Barnestein-Fonseca, P, Berger, M, Boughey, M, Christen, A, De Simone, GG, Egloff, M, Ellershaw, J, Elsten, EECM, Eychmüller, S, Fischer, C, Fürst, CJ, Geijteman, ECT, Goldraij, G, Goossensen, A, Halfdanardottir, SI, Haugen, DF, Hedman, C, Hoppe, T, Hughes, R, Iversen, GS, Joshi, M, Kodba-Ceh, H, Korfage, IJ, Lunder, U, Lüthi, N, Martín-Roselló, ML, Mason, S, Mcglinchey, T, Montilla, S, Rasmussen, BH, Ruiz-Torreras, I, Schelin, MEC, Sigurdardottir, KR, Sigurdardottir, V, Simon, J, Smeding, R, Solvåg, K, Strupp, J, Tripodoro, V, Van Der Kuy, HM, Van Der Rijt, CCD, Van Zuylen, L, Veloso, VI, Vibora-Martin, E, Voltz, R, Zambrano, SC, Van Der Heide, A, Yildiz, B, Allan, S, Bakan, M, Barnestein-Fonseca, P, Berger, M, Boughey, M, Christen, A, De Simone, GG, Egloff, M, Ellershaw, J, Elsten, EECM, Eychmüller, S, Fischer, C, Fürst, CJ, Geijteman, ECT, Goldraij, G, Goossensen, A, Halfdanardottir, SI, Haugen, DF, Hedman, C, Hoppe, T, Hughes, R, Iversen, GS, Joshi, M, Kodba-Ceh, H, Korfage, IJ, Lunder, U, Lüthi, N, Martín-Roselló, ML, Mason, S, Mcglinchey, T, Montilla, S, Rasmussen, BH, Ruiz-Torreras, I, Schelin, MEC, Sigurdardottir, KR, Sigurdardottir, V, Simon, J, Smeding, R, Solvåg, K, Strupp, J, Tripodoro, V, Van Der Kuy, HM, Van Der Rijt, CCD, Van Zuylen, L, Veloso, VI, Vibora-Martin, E, Voltz, R, Zambrano, SC, and Van Der Heide, A

Abstract

Introduction Adequately addressing the needs of patients at the end of life and their relatives is pivotal in preventing unnecessary suffering and optimising their quality of life. The purpose of the iLIVE study is to contribute to high-quality personalised care at the end of life in different countries and cultures, by investigating the experiences, concerns, preferences and use of care of terminally ill patients and their families. Methods and analysis The iLIVE study is an international cohort study in which patients with an estimated life expectancy of 6 months or less are followed up until they die. In total, 2200 patients will be included in 11 countries, that is, 200 per country. In addition, one relative per patient is invited to participate. All participants will be asked to fill in a questionnaire, at baseline and after 4 weeks. If a patient dies within 6 months of follow-up, the relative will be asked to fill in a post-bereavement questionnaire. Healthcare use in the last week of life will be evaluated as well; healthcare staff who attended the patient will be asked to fill in a brief questionnaire to evaluate the care that was provided. Qualitative interviews will be conducted with patients, relatives and healthcare professionals in all countries to gain more in-depth insights. Ethics and dissemination The cohort study has been approved by ethics committees and the institutional review boards (IRBs) of participating institutes in all countries. Results will be disseminated through the project website, publications in scientific journals and at conferences. Within the project, there will be a working group focusing on enhancing the engagement of the community at large with the reality of death and dying. Trial registration number NCT04271085.

Published
2022

14. Development of an international Core Outcome Set (COS) for best care for the dying person: study protocol

Author

Zambrano, S.C. (Sofia C.), Haugen, D.F., Heide, A. (Agnes) van der, Tripodoro, V.A. (Vilma A.), Ellershaw, J.E. (John), Furst, C.J., Voltz, R., Mason, S. (Stephen), Daud, M.L. (Maria Laura), Simone, G. (Gustavo) de, Kremeike, K. (Kerstin), Halfdanardottir, S.I. (Svandis Iris), Sigurdardottir, V. (Valgerdur), Johnson, J. (Jeremy), Allan, S. (Simon), Hafeez, H. (Haroon), Simões, C. (Catarina), Sigurdardottir, K.R., Rasmussen, B.H. (Birgit H.), Williamson, P. (Paula), Eychmüller, S. (Steffen), van der Heide, A. (A.), Geijteman, E.C.T. (Eric), Zuylen, C. (Lia) van, van der Rijt, K. (K.), Korfage, I.J. (Ida), Goossensen, A. (Anne), van der Kuy, H. (H.), Yildiz, B. (B.), Elsten, E. (Eline), Ellershaw, J. (J.), Smeding, R.M. (R. M.), Mason, S. (S.), Mc Glinchey, T. (T.), Hughes, R. (R.), Voltz, R. (R.), Strupp, J. (J.), Joshi, M. (M.), Furst, C.J. (C. J.), Rasmussen, B. (B.), Schelin, M. (M.), Lunder, U. (Urska), Kodba-Čeh, H. (H.), Bakan, M. (M.), Zambrano, S.C. (S. C.), Lüthi, N. (N.), Egloff, M. (M.), Christen, A. (A.), Martin Rosello, M. (M.), Barnestein Fonseca, P. (P.), Ruiz, I. (I.), Haugen, D.R.F. (D. R.F.), Sigurdardottir, K. (K.), Solvag, K. (K.), Skorpen Iversen, G. (G.), Simon, J. (J.), Fisher, C. (C.), Berger, M. (M.), Allan, S. (S.), Boughey, M. (Mark), Zambrano, S.C. (Sofia C.), Haugen, D.F., Heide, A. (Agnes) van der, Tripodoro, V.A. (Vilma A.), Ellershaw, J.E. (John), Furst, C.J., Voltz, R., Mason, S. (Stephen), Daud, M.L. (Maria Laura), Simone, G. (Gustavo) de, Kremeike, K. (Kerstin), Halfdanardottir, S.I. (Svandis Iris), Sigurdardottir, V. (Valgerdur), Johnson, J. (Jeremy), Allan, S. (Simon), Hafeez, H. (Haroon), Simões, C. (Catarina), Sigurdardottir, K.R., Rasmussen, B.H. (Birgit H.), Williamson, P. (Paula), Eychmüller, S. (Steffen), van der Heide, A. (A.), Geijteman, E.C.T. (Eric), Zuylen, C. (Lia) van, van der Rijt, K. (K.), Korfage, I.J. (Ida), Goossensen, A. (Anne), van der Kuy, H. (H.), Yildiz, B. (B.), Elsten, E. (Eline), Ellershaw, J. (J.), Smeding, R.M. (R. M.), Mason, S. (S.), Mc Glinchey, T. (T.), Hughes, R. (R.), Voltz, R. (R.), Strupp, J. (J.), Joshi, M. (M.), Furst, C.J. (C. J.), Rasmussen, B. (B.), Schelin, M. (M.), Lunder, U. (Urska), Kodba-Čeh, H. (H.), Bakan, M. (M.), Zambrano, S.C. (S. C.), Lüthi, N. (N.), Egloff, M. (M.), Christen, A. (A.), Martin Rosello, M. (M.), Barnestein Fonseca, P. (P.), Ruiz, I. (I.), Haugen, D.R.F. (D. R.F.), Sigurdardottir, K. (K.), Solvag, K. (K.), Skorpen Iversen, G. (G.), Simon, J. (J.), Fisher, C. (C.), Berger, M. (M.), Allan, S. (S.), and Boughey, M. (Mark)

Abstract

Background: In contrast to typical measures employed to assess outcomes in healthcare such as mortality or recovery rates, it is difficult to define which specific outcomes of care are the most important in caring for dying individuals. Despite a variety of tools employed to assess different dimensions of palliative care, there is no consensus on a set of core outcomes to be measured in the last days of life. In order to optimise decision making in clinical practice and comparability of interventional studies, we aim to identify and propose a set of core outcomes for the care of the dying person. Methods: Following the COMET initiative approach, the proposed study will proceed through four stages to develop a set of core outcomes: In stage 1, a systematic review of the literature will identify outcomes measured in existing peer reviewed literature, as well as outcomes derived through qualitative studies. Grey literature, will also be included. Stage 2 will allow for the identification and determination of patient and proxy defined outcomes of care at the end of life via quantitative and qualitative methods at an international level. In stage 3, from a list of salient outcomes identified through stages 1 and 2

Published
2020
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17. Biomechanische Testungen verschiedener Osteosyntheseformen bei Azetabulumfrakturen des geriatrischen Patienten

Author

Egloff, M, May, C, Butscher, A, Keel, M, Aebi, T, Siebenrock, K, and Bastian, J

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Zielsetzung: Bei älteren Patienten kommt es gehäuft zu Azetabulumfrakturen der vorderen Pfeilers mit Ausbruch der Quadrilateralen Fläche und medialisiertem Femurkopf. Die Fixation dieser Fraktur soll optimalerweise vor einer erneuten Subluxation nach medial schützen, um die Heilung[zum vollständigen Text gelangen Sie über die oben angegebene URL], 4. Alterstraumatologie Kongress 2018

Published
2018
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19. Diagnostic yield of chromosomal microarray analysis in fetuses with isolated increased nuchal translucency: a French multicenter study

Author

Egloff, M., primary, Hervé, B., additional, Quibel, T., additional, Jaillard, S., additional, Le Bouar, G., additional, Uguen, K., additional, Saliou, A.‐H., additional, Valduga, M., additional, Perdriolle, E., additional, Coutton, C., additional, Coston, A.‐L., additional, Coussement, A., additional, Anselem, O., additional, Missirian, C., additional, Bretelle, F., additional, Prieur, F., additional, Fanget, C., additional, Muti, C., additional, Jacquemot, M.‐C., additional, Beneteau, C., additional, Le Vaillant, C., additional, Vekemans, M., additional, Salomon, L. J., additional, Vialard, F., additional, and Malan, V., additional

Published
2018
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20. Geographical Exploration and Analysis Extended to Textual Content (Short Paper)

Author

Winter, S. (ed.), Griffin, A. (ed.), Sester, M. (ed.), Ceré, R., Egloff, M., Bavaud, F., Winter, S. (ed.), Griffin, A. (ed.), Sester, M. (ed.), Ceré, R., Egloff, M., and Bavaud, F.

Abstract

Textual and socio-economical regional features can be integrated and merged by linearly combining the between-regions corresponding dissimilarities. The scheme accommodates for various squared Euclidean socio-economical and textual dissimilarities (such as chi2 or cosine dissimilarities derived from document-term matrix or topic modelling). Also, spatial configuration of the regions can be represented by a weighted unoriented network whose vertex weights match the relative importance of regions. Association between the network and the dissimilarities expresses in the multivariate spatial autocorrelation index δ, generalizing Moran’s I, whose local version can be cartographied. Our case study bears on the Wikipedia notices and socio-economic profiles for the 2251 Swiss municipalities, whose weights (socio-economical or textual) can be freely chosen.

Published
2018

21. Soft Textual Cartography Based on Topic Modeling and Clustering of Irregular, Multivariate Marked Networks

Author

Cherifi, C. (ed.), Cherifi, H. (ed.), Karsai, M. (ed.), Musolesi, M. (ed.), Egloff, M., Ceré, R., Cherifi, C. (ed.), Cherifi, H. (ed.), Karsai, M. (ed.), Musolesi, M. (ed.), Egloff, M., and Ceré, R.

Abstract

Soft textual cartography is an original approach aimed to study communities on spatially embedded and textually defined complex weighted networks. The present approach relies on the integration of topic modeling and soft clustering procedures. These two aspects can be combined using topic distances, and weighted unoriented networks representing the spatial configuration; their synergy is promising in topic interpretation and geographical information retrieval. This paper proposes an unified formalism, underlining the compatibility of the two aspects, as illustrated on the textual descriptions of the municipalities of the canton of Vaud, Switzerland. It also points to possible extensions and applications of the method, potentially useful for dealing with the ever growing amount of georeferenced textual content.

Published
2018

24. Apport de l’ACPA dans le diagnostic étiologique des fœtus avec hyperclarté nucale au premier trimestre de grossesse : étude rétrospective multicentrique nationale incluant 720 fœtus

Author

Egloff, M., primary, Hervé, B., additional, Jaillard, S., additional, Uguen, K., additional, Valduga, M., additional, Coutton, C., additional, Coussement, A., additional, Missirian, C., additional, Prieur, F., additional, Muti, C., additional, Salomon, L.-J., additional, Vialard, F., additional, and Malan, V., additional

Published
2017
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25. Erratum: Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens (Acta Crystallographica Section D: Biological Crystallography (2006) D62 (1196-1207))

Author

Fogg, M, Alzari, P, Bahar, M, Bertini, I, Betton, J, Burmeister, W, Cambillau, C, Canard, B, Carrondo, M, Coll, M, Daenke, S, Dym, O, Egloff, M, Enguita, F, Geerlof, A, Haouz, A, Jones, T, Ma, Q, Manicka, SN, Migliardi, M, Nordlund, P, Owens, R, Peleg, Y, Schneider, G, and Schnell, R

Published
2016

27. Innervation zone locations in 43 superficial muscles: toward a standardization of electrode positioning

Author

Beretta Piccoli, M, Rainoldi, Alberto, Heitz, C, Wüthrich, M, Boccia, Gennaro, Tomasoni, E, Spirolazzi, C, Egloff, M, and Barbero, M.

Subjects
Adult, Male, Volunteers, Young Adult, Sex Factors, Electromyography, Isometric Contraction, Humans, Female, Muscle, Skeletal, Electrodes, Implanted
Abstract

We describe the innervation zone (IZ) location in 43 muscles to provide information for appropriate positioning of bipolar electrodes for clinical and research applications.The IZ was studied in 40 subjects (20 men and 20 women) using multichannel surface electromyography (sEMG). Signal quality was checked visually to identify motor unit action potentials and estimate muscle fiber conduction velocity.Results in 33 muscles were classified as excellent or good, because it was possible to identify an area which is favorable for appropriate positioning of an electrode pair without the need to previously determine the IZ location.Knowledge of IZ location will increase standardization and repeatability of sEMG measures.

Published
2014

32. Ethical fashion – made in Switzerland?: eine Marktstudie

Author

Starmanns, M, Eggenberger, S, Egloff, M, Gantenbein, B, Grunder, J, Kern, Alice, Meier, M, Roggenbuck, C, Sanders, S, Schlumpf, T, Spescha, G, Steeb, N, Waldburger, D, Weilemann, B, and University of Zurich

Subjects
10122 Institute of Geography, 910 Geography & travel
Published
2009

33. Erratum: Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens (Acta Crystallographica Section D: Biological Crystallography (2006) D62 (1196-1207))

Author

Fogg, MJ, Alzari, P, Bahar, M, Bertini, I, Betton, J-M, Burmeister, WP, Cambillau, C, Canard, B, Carrondo, MA, Coll, M, Daenke, S, Dym, O, Egloff, M-P, Enguita, FJ, Geerlof, A, Haouz, A, Jones, TA, Ma, Q, Manicka, SN, Migliardi, M, Nordlund, P, Owens, RJ, Peleg, Y, Schneider, G, Schnell, R, Stuart, DI, Tarbouriech, N, Unge, T, Wilkinson, AJ, Wilmanns, M, Wilson, KS, Zimhony, O, and Grimes, JM

Published
2006

34. Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens (vol 62, pg 1196, 2006)

Author

Fogg, MJ, Alzari, P, Bahar, M, Bertini, I, Betton, J-M, Burmeister, WP, Cambillau, C, Canard, B, Carrondo, MA, Coll, M, Daenke, S, Dym, O, Egloff, M-P, Enguita, FJ, Geerlof, A, Haouz, A, Jones, TA, Ma, Q, Manicka, SN, Migliardi, M, Nordlund, P, Owens, RJ, Peleg, Y, Schneider, G, Schnell, R, Stuart, DI, Tarbouriech, N, Unge, T, Wilkinson, AJ, Wilmanns, M, Wilson, KS, Zimhony, O, and Grimes, JM

Published
2006

36. Automation of upstream and downstream manufacturing process of cell therapeutic product: gain in quality, yield and consistency with reduced manpower

Author

Willemsen, P., primary, Snykers, S., additional, Codutti, V., additional, Gumy, C., additional, Collignon, F., additional, Goffinet, J., additional, Egloff, M., additional, Drugmand, J., additional, De Vos, B., additional, Sokal, E., additional, Dedry, C., additional, Castillo, J., additional, and Halioua, E., additional

Published
2014
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41. Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens

Author

Fogg, M. J., Alzari, P., Bahar, M., Bertini, I., Betton, J. M., Burmeister, W. P., Cambillau, C., Canard, B., Carrondo, M., Coll, M., Daenke, S., Dym, O., Egloff, M. P., Enguita, F. J., Geerlof, A., Haouz, A., Jones, T. Alwyn, Ma, Qingjun, Manicka, S. N., Migliardi, M., Nordlund, P., Owens, R. J., Peleg, Y., Schneider, G., Schnell, R., Stuart, D. I., Tarbouriech, N., Unge, Torsten, Wilkinson, A. J., Wilmanns, M., Wilson, K. S., Zimhony, O., Grimes, J. M., Fogg, M. J., Alzari, P., Bahar, M., Bertini, I., Betton, J. M., Burmeister, W. P., Cambillau, C., Canard, B., Carrondo, M., Coll, M., Daenke, S., Dym, O., Egloff, M. P., Enguita, F. J., Geerlof, A., Haouz, A., Jones, T. Alwyn, Ma, Qingjun, Manicka, S. N., Migliardi, M., Nordlund, P., Owens, R. J., Peleg, Y., Schneider, G., Schnell, R., Stuart, D. I., Tarbouriech, N., Unge, Torsten, Wilkinson, A. J., Wilmanns, M., Wilson, K. S., Zimhony, O., and Grimes, J. M.

Abstract

The Structural Proteomics In Europe (SPINE) programme is aimed at the development and implementation of high-throughput technologies for the efficient structure determination of proteins of biomedical importance, such as those of bacterial and viral pathogens linked to human health. Despite the challenging nature of some of these targets, 175 novel pathogen protein structures (approximately 220 including complexes) have been determined to date. Here the impact of several technologies on the structural determination of proteins from human pathogens is illustrated with selected examples, including the parallel expression of multiple constructs, the use of standardized refolding protocols and optimized crystallization screens.

Published
2006
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44. Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens. Corrigendum

Author

Fogg, M. J., primary, Alzari, P., additional, Bahar, M., additional, Bertini, I., additional, Betton, J.-M., additional, Burmeister, W. P., additional, Cambillau, C., additional, Canard, B., additional, Carrondo, M. A., additional, Coll, M., additional, Daenke, S., additional, Dym, O., additional, Egloff, M.-P., additional, Enguita, F. J., additional, Geerlof, A., additional, Haouz, A., additional, Jones, T. A., additional, Ma, Qingjun, additional, Manicka, S. N., additional, Migliardi, M., additional, Nordlund, P., additional, Owens, R. J., additional, Peleg, Y., additional, Schneider, G., additional, Schnell, R., additional, Stuart, D. I., additional, Tarbouriech, N., additional, Unge, T., additional, Wilkinson, A. J., additional, Wilmanns, M., additional, Wilson, K. S., additional, Zimhony, O., additional, and Grimes, J. M., additional

Published
2006
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45. The impact of protein characterization in structural proteomics

Author

Geerlof, Arie, primary, Brown, J., additional, Coutard, B., additional, Egloff, M.-P., additional, Enguita, F. J., additional, Fogg, M. J., additional, Gilbert, R. J. C., additional, Groves, M. R., additional, Haouz, A., additional, Nettleship, J. E., additional, Nordlund, P., additional, Owens, R. J., additional, Ruff, M., additional, Sainsbury, S., additional, Svergun, D. I., additional, and Wilmanns, Matthias, additional

Published
2006
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