Search

Your search keyword '"Ehlers, Marc"' showing total 182 results
Start Over Author "Ehlers, Marc"
182 results on '"Ehlers, Marc"'

1. Autoimmune pre-disease

Author

Bieber, Katja, Hundt, Jennifer E., Yu, Xinhua, Ehlers, Marc, Petersen, Frank, Karsten, Christian M., Köhl, Jörg, Kridin, Khalaf, Kalies, Kathrin, Kasprick, Anika, Goletz, Stephanie, Humrich, Jens Y., Manz, Rudolf A., Künstner, Axel, Hammers, Christoph M., Akbarzadeh, Reza, Busch, Hauke, Sadik, Christian D., Lange, Tanja, Grasshoff, Hanna, Hackel, Alexander M., Erdmann, Jeanette, König, Inke, Raasch, Walter, Becker, Mareike, Kerstein-Stähle, Anja, Lamprecht, Peter, Riemekasten, Gabriela, Schmidt, Enno, and Ludwig, Ralf J.

Published
2023
Full Text
View/download PDF

2. The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees

Author

Antinori, Spinello, Bassoli, Cinzia, Bestetti, Giovanna, Corbellino, Mario, Covizzi, Alice, Lupo, Angelica, Milazzo, Laura, Schiuma, Marco, Torre, Alessandro, Appelman, Brent, van de Beek, Diederik, Bomers, Marije K., de Brabander, Justin, Brouwer, Matthijs C., Buis, David T.P., Chekrouni, Nora, van Gils, Marit J., de Jong, Menno D., Lavell, Ayesha H.A., van Mourik, Niels, Olie, Sabine E., Peters, Edgar J.G., Reijnders, Tom D.Y., Schinkel, Michiel, Schuurman, Alex R., Sikkens, Jonne J., Slim, Marleen A., Smulders, Yvo M., Vlaar, Alexander P.J., van Vught, Lonneke A., Wiersinga, Joost W., Van Coillie, Julie, Pongracz, Tamas, Rahmöller, Johann, Chen, Hung-Jen, Geyer, Chiara Elisabeth, Buhre, Jana Sophia, Šuštić, Tonći, van Osch, Thijs Luc Junior, Steenhuis, Maurice, Hoepel, Willianne, Wang, Wenjun, Lixenfeld, Anne Sophie, Nouta, Jan, Keijzer, Sofie, Linty, Federica, Visser, Remco, Larsen, Mads Delbo, Martin, Emily Lara, Künsting, Inga, Lehrian, Selina, von Kopylow, Vera, Kern, Carsten, Lunding, Hanna Bele, de Winther, Menno, Rispens, Theo, Graf, Tobias, Slim, Marleen Adriana, Minnaar, René Peter, Bomers, Marije Kristianne, Sikkens, Jonne Jochum, van der Schoot, C. Ellen, den Dunnen, Jeroen, Wuhrer, Manfred, Ehlers, Marc, and Vidarsson, Gestur

Published
2023
Full Text
View/download PDF

3. Protocol of the Luebeck longitudinal investigation of SARS-CoV-2 infection (ELISA) study – a prospective population-based cohort study

Author

Balck, Alexander, Föh, Bandik, Borsche, Max, Rahmöller, Johann, Vollstedt, Eva-Juliane, Waldeck, Frederike, Käding, Nadja, Twesten, Christoph, Mischnik, Alexander, Gillessen-Kaesbach, Gabriele, Ehlers, Marc, Sina, Christian, Taube, Stefan, Busch, Hauke, Rupp, Jan, Katalinic, Alexander, and Klein, Christine

Published
2022
Full Text
View/download PDF

4. IgG Fc N-Glycosylation Translates MHCII Haplotype into Autoimmune Skin Disease

Author

Clauder, Ann-Katrin, Kordowski, Anna, Bartsch, Yannic C., Köhl, Gabriele, Lilienthal, Gina-Maria, Almeida, Larissa N., Lindemann, Timo, Petry, Janina, Rau, Christina N., Gramalla-Schmitz, Anna, Dühring, Lara, Elbracht, Claudia, Kenno, Samyr, Tillmann, Jenny, Wuhrer, Manfred, Ludwig, Ralf J., Ibrahim, Saleh M., Bieber, Katja, Köhl, Jörg, Ehlers, Marc, and Manz, Rudolf Armin

Published
2021
Full Text
View/download PDF

5. IgG Fc sialylation is regulated during the germinal center reaction following immunization with different adjuvants

Author

Bartsch, Yannic C., Eschweiler, Simon, Leliavski, Alexei, Lunding, Hanna B., Wagt, Sander, Petry, Janina, Lilienthal, Gina-Maria, Rahmöller, Johann, de Haan, Noortje, Hölscher, Alexandra, Erapaneedi, Raghu, Giannou, Anastasios D., Aly, Lilian, Sato, Ryota, de Neef, Louise A., Winkler, André, Braumann, Dominique, Hobusch, Juliane, Kuhnigk, Kyra, Krémer, Vanessa, Steinhaus, Moritz, Blanchard, Véronique, Gemoll, Timo, Habermann, Jens K., Collin, Mattias, Salinas, Gabriela, Manz, Rudolf A., Fukuyama, Hidehiro, Korn, Thomas, Waisman, Ari, Yogev, Nir, Huber, Samuel, Rabe, Björn, Rose-John, Stefan, Busch, Hauke, Berberich-Siebelt, Friederike, Hölscher, Christoph, Wuhrer, Manfred, and Ehlers, Marc

Published
2020
Full Text
View/download PDF

9. Towards a Precise NMR Quantification of Acute Phase Inflammation Proteins from Human Serum

Author

Mallagaray, Alvaro, primary, Rudolph, Lorena, additional, Lindloge, Melissa, additional, Mölbitz, Jarne, additional, Thomsen, Henrik, additional, Schmelter, Franziska, additional, Alhabash, Mohamad Ward, additional, Abdullah, Mohammed R., additional, Saraei, Roza, additional, Ehlers, Marc, additional, Graf, Tobias, additional, Sina, Christian, additional, Petersmann, Astrid, additional, Nauck, Matthias, additional, and Günther, Ulrich L., additional

Published
2023
Full Text
View/download PDF

11. Sialylation of IgE reduces FcεRIα interaction and mast cell and basophil activation in vitro and increases IgE half‐life in vivo

Author

Dühring, Lara, primary, Petry, Janina, additional, Lilienthal, Gina‐Maria, additional, Bartsch, Yannic C., additional, Kubiak, Marie, additional, Pfeufer, Clarissa, additional, Lehrian, Selina, additional, Buhre, Jana S., additional, Lunding, Hanna B., additional, Kern, Carsten, additional, Behrends, Jochen, additional, Walsemann, Theresa, additional, Gädert, Leonie, additional, Sommer, Charline, additional, Krüger, Lynn, additional, Blanchard, Véronique, additional, Dehmel, Susann, additional, Jappe, Uta, additional, Rahmöller, Johann, additional, and Ehlers, Marc, additional

Published
2023
Full Text
View/download PDF

12. mRNA vaccines against SARS-CoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses compared to an adenovirus-based vaccine

Author

Buhre, Jana Sophia, primary, Pongracz, Tamas, additional, Künsting, Inga, additional, Lixenfeld, Anne S., additional, Wang, Wenjun, additional, Nouta, Jan, additional, Lehrian, Selina, additional, Schmelter, Franziska, additional, Lunding, Hanna B., additional, Dühring, Lara, additional, Kern, Carsten, additional, Petry, Janina, additional, Martin, Emily L., additional, Föh, Bandik, additional, Steinhaus, Moritz, additional, von Kopylow, Vera, additional, Sina, Christian, additional, Graf, Tobias, additional, Rahmöller, Johann, additional, Wuhrer, Manfred, additional, and Ehlers, Marc, additional

Published
2023
Full Text
View/download PDF

13. The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees

Author

Van Coillie, Julie, primary, Pongracz, Tamas, additional, Rahmöller, Johann, additional, Chen, Hung-Jen, additional, Geyer, Chiara Elisabeth, additional, van Vught, Lonneke A., additional, Buhre, Jana Sophia, additional, Šuštić, Tonći, additional, van Osch, Thijs Luc Junior, additional, Steenhuis, Maurice, additional, Hoepel, Willianne, additional, Wang, Wenjun, additional, Lixenfeld, Anne Sophie, additional, Nouta, Jan, additional, Keijzer, Sofie, additional, Linty, Federica, additional, Visser, Remco, additional, Larsen, Mads Delbo, additional, Martin, Emily Lara, additional, Künsting, Inga, additional, Lehrian, Selina, additional, von Kopylow, Vera, additional, Kern, Carsten, additional, Lunding, Hanna Bele, additional, de Winther, Menno, additional, van Mourik, Niels, additional, Rispens, Theo, additional, Graf, Tobias, additional, Slim, Marleen Adriana, additional, Minnaar, René Peter, additional, Bomers, Marije Kristianne, additional, Sikkens, Jonne Jochum, additional, Vlaar, Alexander P.J., additional, van der Schoot, C. Ellen, additional, den Dunnen, Jeroen, additional, Wuhrer, Manfred, additional, Ehlers, Marc, additional, Vidarsson, Gestur, additional, Antinori, Spinello, additional, Bassoli, Cinzia, additional, Bestetti, Giovanna, additional, Corbellino, Mario, additional, Covizzi, Alice, additional, Lupo, Angelica, additional, Milazzo, Laura, additional, Schiuma, Marco, additional, Torre, Alessandro, additional, Appelman, Brent, additional, van de Beek, Diederik, additional, Bomers, Marije K., additional, de Brabander, Justin, additional, Brouwer, Matthijs C., additional, Buis, David T.P., additional, Chekrouni, Nora, additional, van Gils, Marit J., additional, de Jong, Menno D., additional, Lavell, Ayesha H.A., additional, Olie, Sabine E., additional, Peters, Edgar J.G., additional, Reijnders, Tom D.Y., additional, Schinkel, Michiel, additional, Schuurman, Alex R., additional, Sikkens, Jonne J., additional, Slim, Marleen A., additional, Smulders, Yvo M., additional, and Wiersinga, Joost W., additional

Published
2023
Full Text
View/download PDF

14. Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line

Author

Vorobyev, Artem, Gupta, Yask, Sezin, Tanya, Koga, Hiroshi, Bartsch, Yannic C., Belheouane, Meriem, Künzel, Sven, Sina, Christian, Schilf, Paul, Körber-Ahrens, Heiko, Beltsiou, Foteini, Lara Ernst, Anna, Khil’chenko, Stanislav, Al-Aasam, Hassanin, Manz, Rudolf A., Diehl, Sandra, Steinhaus, Moritz, Jascholt, Joanna, Kouki, Phillip, Boehncke, Wolf-Henning, Mayadas, Tanya N., Zillikens, Detlef, Sadik, Christian D., Nishi, Hiroshi, Ehlers, Marc, Möller, Steffen, Bieber, Katja, Baines, John F., Ibrahim, Saleh M., and Ludwig, Ralf J.

Published
2019
Full Text
View/download PDF

17. Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions

Author

Epp, Alexandra, Hobusch, Juliane, Bartsch, Yannic C., Petry, Janina, Lilienthal, Gina-Maria, Koeleman, Carolien A.M., Eschweiler, Simon, Möbs, Christian, Hall, Ashley, Morris, Suzanne C., Braumann, Dominique, Engellenner, Christine, Bitterling, Josephine, Rahmöller, Johann, Leliavski, Alexei, Thurmann, Robina, Collin, Mattias, Moremen, Kelley W., Strait, Richard T., Blanchard, Véronique, Petersen, Arnd, Gemoll, Timo, Habermann, Jens K., Petersen, Frank, Nandy, Andreas, Kahlert, Helga, Hertl, Michael, Wuhrer, Manfred, Pfützner, Wolfgang, Jappe, Uta, Finkelman, Fred D., and Ehlers, Marc

Published
2018
Full Text
View/download PDF

18. Current research and unmet needs in allergy and immunology in Germany: report presented by the DGfI and DGAKI task force Allergy & Immunology

Author

Albrecht, Melanie, primary, Schaub, Bianca, additional, Gilles, Stefanie, additional, Köhl, Jörg, additional, Altrichter, Sabine, additional, Voehringer, David, additional, Spillner, Edzard, additional, Ehlers, Marc, additional, Jönsson, Friederike, additional, Loser, Karin, additional, Mayer, Johannes U, additional, Rösner, Lennart M, additional, Möbs, Christian, additional, Heine, Guido, additional, and Pfützner, Wolfgang, additional

Published
2022
Full Text
View/download PDF

19. One-year surveillance of SARS-CoV-2 transmission of the ELISA cohort: A model for population-based monitoring of infection risk

Author

Klein, Christine, primary, Borsche, Max, additional, Balck, Alexander, additional, Föh, Bandik, additional, Rahmöller, Johann, additional, Peters, Elke, additional, Knickmann, Jan, additional, Lane, Miranda, additional, Vollstedt, Eva-Juliane, additional, Elsner, Susanne A., additional, Käding, Nadja, additional, Hauswaldt, Susanne, additional, Lange, Tanja, additional, Hundt, Jennifer E., additional, Lehrian, Selina, additional, Giese, Julia, additional, Mischnik, Alexander, additional, Niemann, Stefan, additional, Maurer, Florian, additional, Homolka, Susanne, additional, Paulowski, Laura, additional, Kramer, Jan, additional, Twesten, Christoph, additional, Sina, Christian, additional, Gillessen-Kaesbach, Gabriele, additional, Busch, Hauke, additional, Ehlers, Marc, additional, Taube, Stefan, additional, Rupp, Jan, additional, and Katalinic, Alexander, additional

Published
2022
Full Text
View/download PDF

20. Additional file 1 of Protocol of the Luebeck longitudinal investigation of SARS-CoV-2 infection (ELISA) study – a prospective population-based cohort study

Author

Balck, Alexander, Föh, Bandik, Borsche, Max, Rahmöller, Johann, Vollstedt, Eva-Juliane, Waldeck, Frederike, Käding, Nadja, Twesten, Christoph, Mischnik, Alexander, Gillessen-Kaesbach, Gabriele, Ehlers, Marc, Sina, Christian, Taube, Stefan, Busch, Hauke, Rupp, Jan, Katalinic, Alexander, and Klein, Christine

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2022
Full Text
View/download PDF

21. Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses

Author

Druzd, David, Matveeva, Olga, Ince, Louise, Harrison, Ute, He, Wenyan, Schmal, Christoph, Herzel, Hanspeter, Tsang, Anthony H., Kawakami, Naoto, Leliavski, Alexei, Uhl, Olaf, Yao, Ling, Sander, Leif Erik, Chen, Chien-Sin, Kraus, Kerstin, de Juan, Alba, Hergenhan, Sophia Martina, Ehlers, Marc, Koletzko, Berthold, Haas, Rainer, Solbach, Werner, Oster, Henrik, and Scheiermann, Christoph

Published
2017
Full Text
View/download PDF

22. Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis

Author

Jendrek, Sebastian Torben, Gotthardt, Daniel, Nitzsche, Thomas, Widmann, Laila, Korf, Tobias, Michaels, Maike Anna, Weiss, Karl-Heinz, Liaskou, Evaggelia, Vesterhus, Mette, Karlsen, Tom Hemming, Mindorf, Swantje, Schemmer, Peter, Bär, Florian, Teegen, Bianca, Schröder, Torsten, Ehlers, Marc, Hammers, Christoph Matthias, Komorowski, Lars, Lehnert, Hendrik, Fellermann, Klaus, Derer, Stefanie, Hov, Johannes Roksund, and Sina, Christian

Published
2017
Full Text
View/download PDF

23. Igg1 protects against renal disease in a mouse model of cryoglobulinaemia

Author

Strait, Richard T., Posgai, Monica T., Mahler, Ashley, Barasa, Nathaniel, Jacob, Chaim O., Kohl, Jorg, Ehlers, Marc, Stringer, Keith, Shanmukhappa, Shiva Kumar, Witte, David, Hossain, Monir, Khodoun, Marat, Herr, Andrew B., and Finkelman, Fred D.

Subjects
Immunoglobulin G -- Analysis -- Models, Monoclonal antibodies -- Analysis -- Models -- Health aspects, Kidney diseases -- Analysis -- Models -- Risk factors -- Diagnosis -- Drug therapy, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Immunoglobulins protect against disease to a considerable extent by activating complement and stimulatory immunoglobulin crystallizable fragment receptors (Ig FcRs), and aggregating microbial pathogens (1, 2). Yet IgG1, the predominant murine serum Ig isotype, cannot activate complement by the classical pathway, binds more avidly to an inhibitory than to stimulatory FcRs, and has limited ability to aggregate pathogens (1-3). In these regards, it resembles human IgG4 (ref. 4). We hypothesized that limited ability to activate effector mechanisms might protect against immune complex immunopathology. Here we show that IgGl-deficient (γ[1.sup.-]) mice (5), immunized with a potent antigen, develop lethal renal disease soon after they begin to produce antigen-specific antibody, whereas similarly immunized wild-type mice remain healthy. Surprisingly, renal disease in this model is complement and FcR independent and results from immune complex precipitation in glomerular capillaries, as in some cryoglobulinaemic humans (6). IgG3, which self-associates to form large immune complexes (7, 8), accounts for more than 97% of the mouse Ig in this cryoglobulin; furthermore, glomerular disease develops when mice are injected with IgG3 anti-trinitrophenyl (TNP) monoclonal antibody followed by a TNP-labelled protein. Renal disease is prevented in both active and passive immunization models by antigen-specific IgG1; other isotypes are less potent at preventing disease. These observations demonstrate the adaptive significance of Ig isotypes that poorly activate effector mechanisms, reveal an immune-complex-dependent, complement- and FcR-independent nephrotoxic mechanism, and suggest that isotypes that poorly activate effector mechanisms may be useful for inhibiting immune complex immunopathology., Immunization of wild-type BALB/c or C57BL/6 mice with a potent immunogen, goat anti-mouse IgD antiserum (GaMD), leads to a large, rapid, predominantly IgG1 antibody response to goat IgG (GIgG) and [...]

Published
2015

25. The BNT162b2 mRNA SARS-CoV-2 Vaccine Induces Transient Afucosylated IgG1 in Naive But Not in Antigen-Experienced Vaccinees

Author

Van Coillie, Julie, primary, Pongracz, Tamas, additional, Rahmöller, Johann, additional, Chen, Hung-Jen, additional, Geyer, Chiara E., additional, van Vught, Lonneke A., additional, Buhre, Jana S., additional, Šuštić, Tonći, additional, van Osch, Thijs L. J., additional, Steenhuis, Maurice, additional, Hoepel, Willianne, additional, Wang, Wenjun, additional, Lixenfeld, Anne S., additional, Nouta, Jan, additional, Keijzer, Sofie, additional, Linty, Federica, additional, Visser, Remco, additional, Larsen, Mads D., additional, Martin, Emily L., additional, Künsting, Inga, additional, Lehrian, Selina, additional, von Kopylow, Vera, additional, Kern, Carsten, additional, Lunding, Hanna B., additional, de Winther, Menno, additional, van Mourik, Niels, additional, Rispens, Theo, additional, Graf, Tobias, additional, Slim, Marleen A., additional, Minnaar, René P., additional, Bomers, Marije, additional, Sikkens, Jonne J., additional, Vlaar, Alexander P. J., additional, van der Schoot, C. Ellen, additional, den Dunnen, Jeroen, additional, Wuhrer, Manfred, additional, Ehlers, Marc, additional, Vidarsson, Gestur, additional, and Physicians Group, Fatebenefratelli-Sacco Infectious D, additional

Published
2022
Full Text
View/download PDF

26. Metabolic and Lipidomic Markers Differentiate COVID-19 From Non-Hospitalized and Other Intensive Care Patients

Author

Schmelter, Franziska, primary, Föh, Bandik, additional, Mallagaray, Alvaro, additional, Rahmöller, Johann, additional, Ehlers, Marc, additional, Lehrian, Selina, additional, von Kopylow, Vera, additional, Künsting, Inga, additional, Lixenfeld, Anne Sophie, additional, Martin, Emily, additional, Ragab, Mohab, additional, Meyer-Saraei, Roza, additional, Kreutzmann, Fabian, additional, Eitel, Ingo, additional, Taube, Stefan, additional, Käding, Nadja, additional, Jantzen, Eckard, additional, Graf, Tobias, additional, Sina, Christian, additional, and Günther, Ulrich L., additional

Published
2021
Full Text
View/download PDF

28. T cell-independent B cell activation induces immunosuppressive sialylated IgG antibodies

Author

Hess, Constanze, Winkler, Andre, Lorenz, Alexandra K., Holecska, Vivien, Blanchard, Veronique, Eiglmeier, Susanne, Schoen, Anna-Lena, Bitterling, Josephine, Stoehr, Alexander D., Petzold, Dominique, Schommartz, Tim, Mertes, Maria M.M., Schoen, Carolin T., Tiburzy, Ben, Herrmann, Anne, Kohl, Jorg, Manz, Rudolf A., Madaio, Michael P., Berger, Markus, Wardemann, Hedda, and Ehlers, Marc

Subjects
Vaccination -- Research, T cells -- Research, Autoimmunity -- Research, B cells -- Research, Health care industry
Abstract

Antigen-specific Abs are able to enhance or suppress immune responses depending on the receptors that they bind on immune cells. Recent studies have shown that pro--or antiinflammatory effector functions of IgG Abs are also regulated through their Fc N-linked glycosylation patterns. IgG Abs that are agalactosylated (non-galactosylated) and asialylated are proinflammatory and induced by the combination of T cell-dependent (TD) protein antigens and proinflammatory costimulation. Sialylated IgG Abs, which are immunosuppres-sive, and Tregs are produced in the presence of TD antigens under tolerance conditions. T cell-independent (TI) B cell activation via B cell receptor (BCR) crosslinking through polysaccharides or via BCR and TLR costimulation also induces IgG Abs, but the Fc glycosylation state of these Abs is unknown. We found in mouse experiments that TI immune responses induced suppressive sialylated IgGs, in contrast to TD proinflam-matory Th1 and Th17 immune responses, which induced agalactosylated and asialylated IgGs. Transfer of low amounts of antigen-specific sialylated IgG Abs was sufficient to inhibit B cell activation and pathogenic immune reactions. These findings suggest an immune regulatory function for TI immune responses through the generation of immunosuppressive sialylated IgGs and may provide insight on the role of TI immune responses during infection, vaccination, and autoimmunity., Introduction Abs regulate the production of new Abs specific for the same antigen via positive or negative feedback mechanisms (1-5). For example, IgG Abs form immune complexes (ICs) with the [...]

Published
2013

29. Cohort-based surveillance of SARS-CoV2 transmission mirrors infection rates at the population level: a one-year longitudinal study

Author

Klein, Christine, primary, Borsche, Max, additional, Balck, Alexander, additional, Föh, Bandik, additional, Rahmöller, Johann, additional, Peters, Elke, additional, Knickmann, Jan, additional, Lane, Miranda, additional, Vollstedt, Eva-Juliane, additional, Elsner, Susanne A., additional, Käding, Nadja, additional, Hauswaldt, Susanne, additional, Lange, Tanja, additional, Hundt, Jennifer E., additional, Lehrian, Selina, additional, Giese, Julia, additional, Mischnik, Alexander, additional, Niemann, Stefan, additional, Maurer, Florian, additional, Homolka, Susanne, additional, Paulowski, Laura, additional, Kramer, Jan, additional, Twesten, Christoph, additional, Sina, Christian, additional, Gillessen-Kaesbach, Gabriele, additional, Busch, Hauke, additional, Ehlers, Marc, additional, Taube, Stefan, additional, Rupp, Jan, additional, and Katalinic, Alexander, additional

Published
2021
Full Text
View/download PDF

30. The BioNTech / Pfizer vaccine BNT162b2 induces class-switched SARS-CoV-2-specific plasma cells and potential memory B cells as well as IgG and IgA serum and IgG saliva antibodies upon the first immunization

Author

Lixenfeld, Anne S., primary, Künsting, Inga, additional, Martin, Emily L., additional, Kopylow, Vera von, additional, Lehrian, Selina, additional, Lunding, Hanna B., additional, Buhre, Jana S., additional, Quack, Janna, additional, Steinhaus, Moritz, additional, Graf, Tobias, additional, Ehlers, Marc, additional, and Rahmöller, Johann, additional

Published
2021
Full Text
View/download PDF

31. Enriched blood IgG sialylation attenuates IgG-mediated and IgG-controlled-IgE-mediated allergic reactions

Author

Petry, Janina, primary, Rahmöller, Johann, additional, Dühring, Lara, additional, Lilienthal, Gina-Maria, additional, Lehrian, Selina, additional, Buhre, Jana Sophia, additional, Bartsch, Yannic C., additional, Epp, Alexandra, additional, Lunding, Hanna B., additional, Moremen, Kelley W., additional, Leliavski, Alexei, additional, and Ehlers, Marc, additional

Published
2021
Full Text
View/download PDF

32. Metabolic markers distinguish COVID-19 from other intensive care patients and show potential to stratify for disease risk

Author

Schmelter, Franziska, primary, Foeh, Bandik, additional, Mallagaray, Alvaro, additional, Rahmoeller, Johann, additional, Ehlers, Marc, additional, Lehrian, Selina, additional, Kopylow, Vera von, additional, Künsting, Inga, additional, Lixenfeld, Anne Sophie, additional, Martin, Emily, additional, Ragab, Mohab, additional, Borsche, Max, additional, Balck, Alexander, additional, Vollstedt, Eva Juliane, additional, Meyer-Saraei, Roza, additional, Kreutzmann, Fabian, additional, Eitel, Ingo, additional, Taube, Stefan, additional, Klein, Christine, additional, Katalinic, Alexander, additional, Rupp, Jan, additional, Jantzen, Eckard, additional, Graf, Tobias, additional, Sina, Christian, additional, and Günther, Ulrich L, additional

Published
2021
Full Text
View/download PDF

33. Spreading of SARS-CoV-2 Among Adult Asylum Seekers in Refugee Shelters in Germany

Author

Alvarez-Fischer, Daniel, primary, Borsche, Max, additional, Balck, Alexander, additional, Föh, Bandik, additional, Hoischen, Arnim, additional, Elsner, Susanne A., additional, Peters, Elke, additional, Rieck, Andrea, additional, Martin, Emily L., additional, Künsting, Inga, additional, Ehlers, Marc, additional, Mischnik, Alexander, additional, Taube, Stefan, additional, Rupp, Jan, additional, Katalinic, Alexander, additional, and Klein, Christine, additional

Published
2021
Full Text
View/download PDF

36. Microbial metabolite butyrate promotes induction of IL-10+IgM+ plasma cells.

Author

Föh, Bandik, Buhre, Jana Sophia, Lunding, Hanna B., Moreno-Fernandez, Maria E., König, Peter, Sina, Christian, Divanovic, Senad, and Ehlers, Marc

Subjects
PLASMA cells, REGULATORY B cells, B cell differentiation, BUTYRATES, SHORT-chain fatty acids, B cells, IMMUNOGLOBULIN M
Abstract

The microbially-derived short-chain fatty acid butyrate is a central inhibitor of inflammatory innate and adaptive immune responses. Emerging evidence suggests that butyrate induces differentiation of IL-10-producing (IL-10+) regulatory B cells. However, the underlying mechanisms of butyrate-driven modulation of B cell differentiation are not fully defined. Given the dominant role of regulatory plasma cells (PCs) as the main source of anti-inflammatory cytokines including IL-10 and the observation that butyrate also induces the differentiation of PCs, we here investigated the effect of the microbial metabolite butyrate on the induction of regulatory IL-10+ PCs and underlying mechanisms. Here we show that butyrate induces the differentiation of IL-10+IgM+ PCs. Ex vivo, butyrate, but hardly propionate, another microbially-derived short-chain fatty acid, induced the differentiation of IL-10+IgM+ CD138high PCs from isolated splenic murine B cells. In vivo, administration of butyrate via drinking water or by daily intraperitoneal injection increased the number of IL-10+IgM+ CD138high PCs in the spleens of Ovalbumin (Ova)/complete Freund's adjuvant-immunized mice. The induction of these regulatory PCs was associated with an increase of anti-Ova IgM, but a reduction of anti-Ova class-switched pathogenic IgG2b serum antibodies. Based on the knowledge that butyrate inhibits histone deacetylases (HDACs) thereby increasing histone acetylation, we identified here that HDAC3 inhibition was sufficient to induce PC differentiation and IL-10+ expression. Furthermore, reduced mitochondrial superoxide levels following butyrate treatment and HDAC3 inhibition were necessary for PC differentiation, but not IL-10 expression. In summary, the microbial metabolite butyrate promotes the differentiation of IgM+ PCs and their expression of IL-10. HDAC3 inhibition may be involved as an underlying pathway for both PC differentiation and IL-10 expression, while reduced mitochondrial superoxide levels are crucial only for PC differentiation. The induction of regulatory IL-10+IgM+ PCs and the inhibition of class switching to antigen-specific pathogenic IgG subclasses might represent important pathways of butyrate to limit inflammation. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

37. MHC haplotype and B cell autoimmunity: Correlation with pathogenic IgG autoantibody subclasses and Fc glycosylation patterns.

Author

Nogueira Almeida, Larissa, Clauder, Ann‐Katrin, Meng, Lingzhang, Ehlers, Marc, Arce, Sergio, and Manz, Rudolf Armin

Subjects
AUTOIMMUNE diseases, B cells, AUTOANTIBODIES, AUTOIMMUNITY, IMMUNOLOGICAL tolerance, GENOME-wide association studies
Abstract

Genome‐wide association studies (GWAS) have identified many genes that are associated with the development of certain autoimmune disorders, but the MHC haplotypes still represent the most prevalent genetic risk factor for many autoimmune diseases. The mechanisms by which MHC‐associated genetic susceptibility translates into B cell autoimmunity and the development of autoimmune diseases are complex. There is increasing evidence that the MHC haplotype modulates autoreactive B cell responses in multiple ways. Instead of merely inhibiting the production of IgG autoantibodies and mediating complete immunological tolerance, the non‐permitting MHC haplotypes seem to facilitate the production of IgG autoantibodies exhibiting Fc glycosylation patterns that are associated with reduced pathogenicity and a protective cytokine profile of T follicular helper (Tfh) cells. Here, we discuss mechanisms linking MHC haplotypes to the production of pathogenic IgG autoantibodies, which could be relevant for the development of improved diagnosis, particularly in the context of individual medicine. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

39. Which adjuvants for tumor-antigen vaccination induce powerful non-sialylated IgG antibodies?

Author

Bartsch, Yannic and Ehlers, Marc

Subjects
carbohydrates (lipids)
Abstract

Tumor-antigen vaccination is a promissing approach to induce intensive T and B cell and IgG antibody responses for eliminating the tumor. The effector functions of IgG antibodies depend on their subclass and Fc glycosylation pattern. Non-fucosylation and non-sialylation of tumor-antigen-specific IgG antibodies enhance their affinity to activating Fcgamma receptors on immune cells and enhance tumor elimination. Accordingly, it has been suggested that tumor-antigen vaccination should induce non-fucosylated and non-sialylated tumor-antigen-specific IgG antibodies. We have analyzed, which adjuvants induce or not non-sialylated IgG antibodies and what are the responsible mechanisms and have identified an IL-17 dependent mechanism for the generation of non-sialylated IgG antibodies. We conclude that adjuvants interesting for tumor-antigen vaccination can be selected by their potential to induce non-sialylated IgG antibodies., Proceedings on Cancer-Immuno-Oncology, Vol 1 No 1 (2018)

Published
2018
Full Text
View/download PDF

40. Tolerance induction with T cell–dependent protein antigens induces regulatory sialylated IgGs

Author

Oefner, Carolin M., Winkler, André, Hess, Constanze, Lorenz, Alexandra K., Holecska, Vivien, Huxdorf, Melanie, Schommartz, Tim, Petzold, Dominique, Bitterling, Josephine, Schoen, Anna-Lena, Stoehr, Alexander D., Vu Van, Dana, Darcan-Nikolaisen, Yasemin, Blanchard, Véronique, Schmudde, Inken, Laumonnier, Yves, Ströver, Heike A., Hegazy, Ahmed N., Eiglmeier, Susanne, Schoen, Carolin T., Mertes, Maria M.M., Loddenkemper, Christoph, Löhning, Max, König, Peter, Petersen, Arnd, Luger, Elke O., Collin, Mattias, Köhl, Jörg, Hutloff, Andreas, Hamelmann, Eckard, Berger, Markus, Wardemann, Hedda, and Ehlers, Marc

Published
2012
Full Text
View/download PDF

41. Sialylated autoantigen-reactive IgG antibodies attenuate disease development in mouse models of lupus nephritis and rheumatoid arthritis

Author

Rahmöller, Johann, Bartsch, Yannic C., Leliavski, Alexei, Lilienthal, Gina-Maria, Petry, Janina, and Ehlers, Marc

Abstract

Pro- and anti-inflammatory effector functions of IgG antibodies (Abs) depend on their subclass and Fc glycosylation pattern. Accumulation of non-galactosylated (agalactosylated; G0) IgG Abs in the serum of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients reflects severity of the diseases. In contrast, sialylated IgG Abs are responsible for anti-inflammatory effects of the intravenous immunoglobulin (IVIG; pooled human serum IgG from healthy donors), administered in high doses (2 g/kg) to treat autoimmune patients. However, whether low amounts of sialylated autoantigen-reactive IgG Abs can also inhibit autoimmune diseases has been hardly investigated. Here, we explored whether sialylated autoantigen-reactive IgG Abs can inhibit autoimmune pathology in two mouse models (Bartsch et al., Front. Immunol. 2018; 9:1183). We found that sialylated IgG autoantibodies fail to induce inflammation and lupus nephritis in a B cell receptor (BCR) transgenic lupus model, but instead are associated with lower frequencies of pathogenic Th1, Th17 and B cell responses. In accordance, the transfer of small amounts of immune complexes containing sialylated IgG Abs was sufficient to attenuate the development of nephritis. We further showed that administration of sialylated collagen type II (Col II)-specific IgG Abs attenuated the disease symptoms in a model of Col II-induced arthritis and reduced pathogenic Th17 cell and autoantigen-specific IgG Ab responses. We conclude that sialylated autoantigen-specific IgG Abs may represent a promising tool for treating pathogenic T and B cell immune responses in autoimmune diseases., Advances in RAB Research, Vol 1 No 1 (2018)

Published
2018
Full Text
View/download PDF

44. Sialylated Autoantigen-Reactive IgG Antibodies Attenuate Disease Development in Autoimmune Mouse Models of Lupus Nephritis and Rheumatoid Arthritis

Author

Bartsch, Yannic C., primary, Rahmöller, Johann, additional, Mertes, Maria M. M., additional, Eiglmeier, Susanne, additional, Lorenz, Felix K. M., additional, Stoehr, Alexander D., additional, Braumann, Dominique, additional, Lorenz, Alexandra K., additional, Winkler, André, additional, Lilienthal, Gina-Maria, additional, Petry, Janina, additional, Hobusch, Juliane, additional, Steinhaus, Moritz, additional, Hess, Constanze, additional, Holecska, Vivien, additional, Schoen, Carolin T., additional, Oefner, Carolin M., additional, Leliavski, Alexei, additional, Blanchard, Véronique, additional, and Ehlers, Marc, additional

Published
2018
Full Text
View/download PDF

46. Pathogenetic and Clinical Aspects of Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitides

Author

Lamprecht, Peter, primary, Kerstein, Anja, additional, Klapa, Sebastian, additional, Schinke, Susanne, additional, Karsten, Christian M., additional, Yu, Xinhua, additional, Ehlers, Marc, additional, Epplen, Jörg T., additional, Holl-Ulrich, Konstanze, additional, Wiech, Thorsten, additional, Kalies, Kathrin, additional, Lange, Tanja, additional, Laudien, Martin, additional, Laskay, Tamas, additional, Gemoll, Timo, additional, Schumacher, Udo, additional, Ullrich, Sebastian, additional, Busch, Hauke, additional, Ibrahim, Saleh, additional, Fischer, Nicole, additional, Hasselbacher, Katrin, additional, Pries, Ralph, additional, Petersen, Frank, additional, Weppner, Gesche, additional, Manz, Rudolf, additional, Humrich, Jens Y., additional, Nieberding, Relana, additional, Riemekasten, Gabriela, additional, and Müller, Antje, additional

Published
2018
Full Text
View/download PDF

48. Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis

Author

Jendrek, Sebastian Torben, primary, Gotthardt, Daniel, additional, Nitzsche, Thomas, additional, Widmann, Laila, additional, Korf, Tobias, additional, Michaels, Maike Anna, additional, Weiss, Karl-Heinz, additional, Liaskou, Evaggelia, additional, Vesterhus, Mette, additional, Karlsen, Tom Hemming, additional, Mindorf, Swantje, additional, Schemmer, Peter, additional, Bär, Florian, additional, Teegen, Bianca, additional, Schröder, Torsten, additional, Ehlers, Marc, additional, Hammers, Christoph Matthias, additional, Komorowski, Lars, additional, Lehnert, Hendrik, additional, Fellermann, Klaus, additional, Derer, Stefanie, additional, Hov, Johannes Roksund, additional, and Sina, Christian, additional

Published
2016
Full Text
View/download PDF

49. Erratum: IgG1 protects against renal disease in a mouse model of cryoglobulinaemia

Author

Strait, Richard T., primary, Posgai, Monica T., additional, Mahler, Ashley, additional, Barasa, Nathaniel, additional, Jacob, Chaim O., additional, Köhl, Jörg, additional, Ehlers, Marc, additional, Stringer, Keith, additional, Shanmukhappa, Shiva Kumar, additional, Witte, David, additional, Hossain, Md Monir, additional, Khodoun, Marat, additional, Herr, Andrew B., additional, and Finkelman, Fred D., additional

Published
2015
Full Text
View/download PDF

50. IgG1 protects against renal disease in a mouse model of cryoglobulinaemia

Author

Strait, Richard T., primary, Posgai, Monica T., additional, Mahler, Ashley, additional, Barasa, Nathaniel, additional, Jacob, Chaim O., additional, Köhl, Jörg, additional, Ehlers, Marc, additional, Stringer, Keith, additional, Shanmukhappa, Shiva Kumar, additional, Witte, David, additional, Hossain, Md Monir, additional, Khodoun, Marat, additional, Herr, Andrew B., additional, and Finkelman, Fred D., additional

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results