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Your search keyword '"Ehrich, J.H.H."' showing total 38 results
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38 results on '"Ehrich, J.H.H."'

1. Nephrologie

Author

Ehrich, J.H.H., Gröne, H.-J., Zappe, H.F., Speer, Christian P., and Gahr, Manfred

Published
2005
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15. Equivalent efficacy of HES 130/0.4 and albumin infusions in children

Author

Pape, L. and Ehrich, J.H.H.

Subjects
Serum albumin -- Dosage and administration, Serum albumin -- Health aspects, Infusion therapy -- Evaluation, Infusion therapy -- Health aspects, Nephrotic syndrome -- Diagnosis, Nephrotic syndrome -- Care and treatment, Health
Abstract

Table of Contents Abstract Introduction Patients Results Conclusion References Abstract Human albumin (HA20%) is an expensive blood product, used for infusion therapy in children with nephrotic syndrome and underfill. As [...]

Published
2008

34. A single center clinical experience in intensive care management of 104 pediatric renal transplantations between 1998 and 2002.

Author

Pape, L., Offner, G., Ehrich, J.H.H., and Sasse, M.

Subjects
CRITICAL care medicine, KIDNEY transplantation, TRANSPLANTATION of organs, tissues, etc. in children, HEPARIN, HYPOTENSION, PEDIATRICS
Abstract

Pape L, Offner G, Ehrich JHH, Sasse M. A single center clinical experience in intensive care management of 104 pediatric renal transplantations between 1998 and 2002. Pediatr Transplantation 2004: 8: 39–43. © 2004 Blackwell Munksgaard Only a few publications about the treatment in the intensive care unit (ICU) after pediatric renal transplantation have been published yet. As there are no guidelines, we hereby describe the results and recommendations of our transplant unit. A total of 104 renal transplantations have been performed in 96 children at our center since 1998. The age of the children has ranged from 6 months to 18 yr and their body weight from 6 kg to 110 kg. A special fluid management was performed in order to avoid hypotension and hypoperfusion of the graft. Systolic arterial pressure was kept at elevated levels above 100 mmHg during the first day after transplantation. The children remained on the respirator for 4–8 h after transplantation. Anticoagulation was performed using low dose heparin because of the size mismatch of the anastomosed vessels. The mean time in the ICU for the pediatric patients aged <3 yr was 2 days and for children older than 3 yr was 1 day. The main complications after renal transplantation in the ICU were disorders of electrolytes, acute renal failure because of a non-functioning graft (12%), bleeding from the anastomoses (4%), arterial or venous thrombosis (1%), arterial hypertension and pulmonary edema, defined as radiographic evidence (1%). In case of non-function peritoneal- or hemodialysis were performed in the ICU. Young children were more frequently affected than older children. From 1998–2002 one patient died during the ICU time. The 3 yr graft survival rate was 90%. To sum up, children undergoing renal transplantation should be treated in a specialized unit postoperatively to avoid early non-functioning of the graft and extrarenal complications. General guidelines for postoperative care should be established. [ABSTRACT FROM AUTHOR]

Published
2004
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36. Oxygen Transport Properties in Malaria-Infected Rodents — A Comparison Between Infected and Noninfected Erythrocytes

Author

Schmidt, W., Correa, R., Boning, D., Ehrich, J.H.H., and Krüger, C.

Abstract

This study was performed to investigate oxygen transport properties in whole blood (WB) of malaria-infected rats as well as in infected erythrocytes (IE) and noninfected erythrocytes (NIE) separated by density centrifugation. One week after inoculation with Plasmodium berghei, mean parasitemia was 26.5% and high correlations were found between parasitemia and hemoglobin concentration ([Hb]; r= -.902), mean cellular Hb concentration (MCHC; r = -.712), MetHb (r = .923), and base excess (r = -.922). Compared with control animals (C), the oxygen affinity was lower in WB under standard (pH 7.40) and simulated “in vivo” (pH 7.00) conditions (difference in P50, 5.7 and 5.1 mm Hg, respectively; 2P< .01, 2P< .05). In IE Hb and 2,3-biphosphoglycerate (2,3-BPG) concentrations were decreased (MCHC: IE 14.6 ± 1.0, NIE 33.1 ± 1.7 g/100 mL; [2,3-BPG]: IE 2.0 ± 0.6, NIE 7.6 ± 1.8 mmol/L), whereas [MetHb] and [ATP] were increased ([MetHb]: IE 19.0 ± 3.7, NIE 0.7% ± 0.8%; [ATP]: IE 33.5 ± 2.4, NIE 6.2 ± 1.0 μmol/g Hb). At pH 7.40, half-saturation oxygen tension (P50) was reduced in IE (29.6 ± 2.6, NIE 39.2 ± 5.4 mm Hg, 2P< .001), which correlates with lower [2,3-BPG], increased MetHb content, and higher intrinsic Hb-O2affinity. However, at pH 7.00, the oxygen affinity was lower in IE when compared with NIE, which was most likely due to high [ATP] in IE. The resulting Bohr coefficients (BC) calculated for CO2and lactic acid were extremely high in IE and low in NIE (at 50% O2-saturation BCCO2: IE -1.04 ± 0.06.NIE -0.26 ± 0.10, 2P< .001; BCLac: IE -0.82 ± 0.16, NIE -0.47 ± 0.07, 2P< .001), which was caused by different [2,3-BPG] and [ATP] as well as probably by structural changes of the Hb molecule. The O2capacity was 14.1 mL per 100 mL erythrocytes in IE compared with 44.4 mL/100 mL in NIE. On the basis of the calculated arterio-venous O2difference under “in vivo” conditions, the infected red blood cell fraction transports 30% of the O2amount delivered to the tissues by the noninfected cells (IE 8.0, NIE 26.9 mL/100 mL red blood cells). We conclude that the O2transport in malaria infected blood is not only affected by the degree of anemia but also by the percentage of infected erythrocytes.

Published
1994
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