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6. [Water diuresis during methohexitone anaesthesia. Studies in chronically instrumented dogs (author's transl)].

Author

Kuhl U, Kaczmarcyk G, Riedel J, Eigenheer F, Eisele R, and Reinhardt HW

Subjects
Animals, Arginine Vasopressin pharmacology, Blood Pressure drug effects, Cardiac Output drug effects, Dogs, Drug Antagonism, Female, Heart Atria, Heart Rate drug effects, Kidney blood supply, Natriuresis drug effects, Potassium urine, Regional Blood Flow drug effects, Urea urine, Water metabolism, Anesthesia, Diuresis drug effects, Methohexital pharmacology
Abstract

Seven chronically prepared dogs (electromagnetic flow transducers around the pulmonary and left renal artery, left atrial catheter) maintained on a controlled sodium and water intake were studied. About 20 h after the last intake of food and water, the effects of i.v. methohexitone (initial dose: 6.10 +/- 0.84 mg/kg bw; sustaining infusion: 0.34 +/- 0.10 mg/min.kg bw) on renal excretion of sodium, potassium, urea and water as well as on several haemodynamic values were investigated over a period of 60 min (MP) after a control period (CP) of 60 min in the unanaesthetized state. In 18 of 19 experiments water diuresis (U/Posm less than 1) was observed between 20 and 40 min after starting the administration of methohexitone. Urine volume increased from 44 +/- 21 microliter/min.kg bw (CP) to 104 +/- 62 microliter/min.kg bw (MP).I.v. administration of arginine-vasopressin (ADH) completely abolished water diuresis. During MP, there was a decrease in cardiac output (-11%), stroke volume (-36%) and left atrial pressure (-27%), heart rate increased (+ 43%). Mean arterial blood pressure and renal blood flow did not change. It is assumed-as plasma osmolality did not change-that the central release of antidiuretic hormone is suppressed by methohexitone.

Published
1978

7. [Experimental studies in animals on the effects of etomidate (R 26 490-sulfate) on the circulation and on the oxygenation of the myocardium (author's transl)].

Author

Weymar A, Eigenheer F, Gethmann JW, Reinecke A, Patschke D, Tarnow J, and Brückner JB

Subjects
Animals, Benzyl Compounds pharmacology, Blood Pressure drug effects, Cardiac Output drug effects, Chemical Phenomena, Chemistry, Coronary Circulation drug effects, Dogs, Electrocardiography, Female, Heart Rate drug effects, Male, Myocardium metabolism, Oxygen blood, Blood Circulation drug effects, Heart drug effects, Hypnotics and Sedatives pharmacology, Imidazoles pharmacology, Oxygen Consumption drug effects
Published
1974

8. [Use of the electron microscope in the diagnosis of obscure virus infection s. Herpesvirus encephalitis and post-vaccinal keratitis].

Author

Löffler H, Bienz K, Schmid U, and Eigenheer F

Subjects
Autopsy, Brain microbiology, Diagnosis, Differential, Female, Herpesviridae isolation & purification, Humans, Keratitis etiology, Methods, Middle Aged, Neutralization Tests, Tears microbiology, Vaccination adverse effects, Vaccinia virus isolation & purification, Encephalitis diagnosis, Herpesviridae Infections diagnosis, Keratitis diagnosis, Microscopy, Electron, Smallpox Vaccine adverse effects, Vaccinia diagnosis
Published
1970

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