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2. Brain functional imaging contributions in osteoarthritis-related pain: A viewpoint

Author

Alliot-Launois, Françoise, Attal, Nadine, Berenbaum, Francis, Binvignat, Marie, Conaghan, Philip, Courties, Alice, Eijkelkamp, Niels, Fauchon, Camille, Geenen, Rinie, Haugen, Ida K., Henrotin, Yves, Kisand, Kalle, Kloppenburg, Margreet, Kosek, Eva, Kuhi, Liisa, Mathieu, Sylvain, Mathy, Céline, Mobasheri, Ali, Talla, Stanislas Moumbe, Omoumi, Patrick, Perrot, Serge, Peyron, Roland, Saarakkala, Simo, Saraux, Alain, Schaible, Hans-Georg, Sellam, Jérémie, and Conaghan, Philip G.

Published
2025
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7. Insights into FcγR involvement in pain-like behavior induced by an RA-derived anti-modified protein autoantibody

Author

Jurczak, Alexandra, Sandor, Katalin, Bersellini Farinotti, Alex, Krock, Emerson, Hunt, Matthew A., Agalave, Nilesh M., Barbier, Julie, Simon, Nils, Wang, Zhenggang, Rudjito, Resti, Vazquez-Mora, Juan Antonio, Martinez-Martinez, Arisai, Raoof, Ramin, Eijkelkamp, Niels, Grönwall, Caroline, Klareskog, Lars, Jimenéz-Andrade, Juan Miguel, Marchand, Fabien, and Svensson, Camilla I.

Published
2023
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10. Identifying disrupted biological factors and patient-tailored interventions for chronic fatigue in adolescents and young adults with Q-Fever Fatigue Syndrome, Chronic Fatigue Syndrome and Juvenile Idiopathic Arthritis (QFS-study): study protocol for a randomized controlled trial with single-subject experimental case series design

Author

Vroegindeweij, Anouk, Swart, Joost F., Houtveen, Jan, Eijkelkamp, Niels, van de Putte, Elise M., Wulffraat, Nico M., and Nijhof, Sanne L.

Published
2022
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12. Human IAPP is a contributor to painful diabetic peripheral neuropathy

Author

Albariqi, Mohammed M.H., Versteeg, Sabine, Brakkee, Elisabeth M., Coert, J. Henk, Elenbaas, Barend O.W., Prado, Judith, Hack, C. Erik, Hoppener, Jo W.M., and Eijkelkamp, Niels

Subjects
Diagnosis, Complications and side effects, Analysis, Pancreatic beta cells -- Analysis, Diabetes mellitus -- Diagnosis -- Complications and side effects, Diabetes -- Diagnosis -- Complications and side effects
Abstract

Introduction Diabetes mellitus (DM) is a metabolic disorder that affects around 463 million individuals globally (1). DM is one of the most significant worldwide health issues, diminishing quality of life [...], Peripheral neuropathy is a frequent complication of type 2 diabetes mellitus (T2DM). We investigated whether human islet amyloid polypeptide (hIAPP), which forms pathogenic aggregates that damage pancreatic islet [beta] cells in T2DM, is involved in T2DM-associated peripheral neuropathy. In vitro, hIAPP incubation with sensory neurons reduced neurite outgrowth and increased levels of mitochondrial reactive oxygen species. hIAPP-transgenic mice, which have elevated plasma hIAPP levels without hyperglycemia, developed peripheral neuropathy as evidenced by pain-associated behavior and reduced intraepidermal nerve fiber (IENF) density. Similarly, hIAPP Ob/Ob mice, which have hyperglycemia in combination with elevated plasma hIAPP levels, had signs of neuropathy, although more aggravated. In wild-type mice, intraplantar and intravenous hIAPP injections induced long-lasting allodynia and decreased IENF density. Non-aggregating murine IAPP, mutated hIAPP (pramlintide), or hIAPP with pharmacologically inhibited aggregation did not induce these effects. T2DM patients had reduced IENF density and more hIAPP oligomers in the skin compared with non-T2DM controls. Thus, we provide evidence that hIAPP aggregation is neurotoxic and mediates peripheral neuropathy in mice. The increased abundance of hIAPP aggregates in the skin of T2DM patients supports the notion that hIAPP is a potential contributor to T2DM neuropathy in humans.

Published
2023
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13. Lower hair cortisol concentration in adolescent and young adult patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Q-Fever Fatigue Syndrome compared to controls

Author

Sociale pediatrie onderzoek 2, Infection & Immunity, CTI Eijkelkamp, Brain, Cancer, Child Health, Sociale Pediatrie patientenzorg, Regenerative Medicine and Stem Cells, Immuno/reuma ERN, Immuno/reuma patientenzorg, Vroegindeweij, Anouk, Eijkelkamp, Niels, van den Berg, Sjoerd A A, van de Putte, Elise M, Wulffraat, Nico M, Swart, Joost F, Nijhof, Sanne L, Sociale pediatrie onderzoek 2, Infection & Immunity, CTI Eijkelkamp, Brain, Cancer, Child Health, Sociale Pediatrie patientenzorg, Regenerative Medicine and Stem Cells, Immuno/reuma ERN, Immuno/reuma patientenzorg, Vroegindeweij, Anouk, Eijkelkamp, Niels, van den Berg, Sjoerd A A, van de Putte, Elise M, Wulffraat, Nico M, Swart, Joost F, and Nijhof, Sanne L

Published
2024

15. Myostatin and CXCL11 promote nervous tissue macrophages to maintain osteoarthritis pain

Author

CTI Eijkelkamp, Infection & Immunity, MS Reumatologie/Immunologie/Infectie, Regenerative Medicine and Stem Cells, Cancer, Brain, Child Health, Gil, Christian Martín, Raoof, Ramin, Versteeg, Sabine, Willemen, Hanneke L D M, Lafeber, Floris P J G, Mastbergen, Simon C, Eijkelkamp, Niels, CTI Eijkelkamp, Infection & Immunity, MS Reumatologie/Immunologie/Infectie, Regenerative Medicine and Stem Cells, Cancer, Brain, Child Health, Gil, Christian Martín, Raoof, Ramin, Versteeg, Sabine, Willemen, Hanneke L D M, Lafeber, Floris P J G, Mastbergen, Simon C, and Eijkelkamp, Niels

Published
2024

16. The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes

Author

Davydova, Erna, Shimazu, Tadahiro, Schuhmacher, Maren Kirstin, Jakobsson, Magnus E., Willemen, Hanneke L. D. M., Liu, Tongri, Moen, Anders, Ho, Angela Y. Y., Małecki, Jędrzej, Schroer, Lisa, Pinto, Rita, Suzuki, Takehiro, Grønsberg, Ida A., Sohtome, Yoshihiro, Akakabe, Mai, Weirich, Sara, Kikuchi, Masaki, Olsen, Jesper V., Dohmae, Naoshi, Umehara, Takashi, Sodeoka, Mikiko, Siino, Valentina, McDonough, Michael A., Eijkelkamp, Niels, Schofield, Christopher J., Jeltsch, Albert, Shinkai, Yoichi, and Falnes, Pål Ø.

Published
2021
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22. Inflammation-induced mitochondrial and metabolic disturbances in sensory neurons control the switch from acute to chronic pain

Author

Willemen, Hanneke L.D.M., primary, Santos Ribeiro, Patrícia Silva, additional, Broeks, Melissa, additional, Meijer, Nils, additional, Versteeg, Sabine, additional, Tiggeler, Annefien, additional, de Boer, Teun P., additional, Małecki, Jędrzej M., additional, Falnes, Pål Ø., additional, Jans, Judith, additional, and Eijkelkamp, Niels, additional

Published
2023
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Author

CTI Eijkelkamp, Brain, Cancer, Child Health, Infection & Immunity, Jurczak, Alexandra, Sandor, Katalin, Bersellini Farinotti, Alex, Krock, Emerson, Hunt, Matthew A, Agalave, Nilesh M, Barbier, Julie, Simon, Nils, Wang, Zhenggang, Rudjito, Resti, Vazquez-Mora, Juan Antonio, Martinez-Martinez, Arisai, Raoof, Ramin, Eijkelkamp, Niels, Grönwall, Caroline, Klareskog, Lars, Jimenéz-Andrade, Juan Miguel, Marchand, Fabien, Svensson, Camilla I, CTI Eijkelkamp, Brain, Cancer, Child Health, Infection & Immunity, Jurczak, Alexandra, Sandor, Katalin, Bersellini Farinotti, Alex, Krock, Emerson, Hunt, Matthew A, Agalave, Nilesh M, Barbier, Julie, Simon, Nils, Wang, Zhenggang, Rudjito, Resti, Vazquez-Mora, Juan Antonio, Martinez-Martinez, Arisai, Raoof, Ramin, Eijkelkamp, Niels, Grönwall, Caroline, Klareskog, Lars, Jimenéz-Andrade, Juan Miguel, Marchand, Fabien, and Svensson, Camilla I

Published
2023

28. Sustained release of locally delivered celecoxib provides pain relief for osteoarthritis: a proof of concept in dog patients

Author

Tellegen, Anna R, Rudnik-Jansen, Imke, Utomo, Lizette, Versteeg, Sabine, Beukers, Martijn, Maarschalkerweerd, Roelof, van Zuilen, Dick, van Klaveren, Nicoline J, Houben, Kaat, Teske, Erik, René van Weeren, P, Karssemakers-Degen, Nina, Mihov, George, Thies, Jens, Eijkelkamp, Niels, Creemers, Laura B, Meij, Björn P, Tryfonidou, Marianna A, Tellegen, Anna R, Rudnik-Jansen, Imke, Utomo, Lizette, Versteeg, Sabine, Beukers, Martijn, Maarschalkerweerd, Roelof, van Zuilen, Dick, van Klaveren, Nicoline J, Houben, Kaat, Teske, Erik, René van Weeren, P, Karssemakers-Degen, Nina, Mihov, George, Thies, Jens, Eijkelkamp, Niels, Creemers, Laura B, Meij, Björn P, and Tryfonidou, Marianna A

Abstract

Objective: Drug delivery platforms that allow for gradual drug release after intra-articular administration have become of much interest as a treatment strategy for osteoarthritis (OA). The aim of this study was to investigate the safety and efficacy of an intra-articular sustained release formulation containing celecoxib (CXB), a cyclooxygenase-2 (COX-2) selective inhibitor. Methods: Amino acid-based polyesteramide microspheres (PEAMs), a biodegradable and non-toxic platform, were loaded with CXB and employed in two in vivo models of arthritis: an acute inflammatory arthritis model in rats (n = 12), and a randomized controlled study in chronic OA dog patients (n = 30). In parallel, the bioactivity of sustained release of CXB was evaluated in monolayer cultures of primary dog chondrocytes under inflammatory conditions. Results: Sustained release of CXB did not alleviate acute arthritis signs in the rat arthritis model, based on pain measurements and synovitis severity. However, in OA dog patients, sustained release of CXB improved limb function as objective parameter of pain and quality of life based on gait analysis and owner questionnaires. It also decreased pain medication dependency over a 2-month period and caused no adverse effects. Prostaglandin E2 levels, a marker for inflammation, were lower in the synovial fluid of CXB-treated dog OA patients and in CXB-treated cultured dog chondrocytes. Conclusion: These results show that local sustained release of CXB is less suitable to treat acute inflammation in arthritic joints, while safe and effective in treating pain in chronic OA in dogs.

Published
2023

29. Surgery and Behavioral Testing in the Tibial Neuroma Transposition Model in Rats

Author

Zorgeenheid Plastische Chirurgie Medisch, CTI Eijkelkamp, Brain, Cancer, Child Health, Infection & Immunity, Brakkee, Elisabeth Maria, Devinney, Erick, Eijkelkamp, Niels, Coert, J. Henk, Zorgeenheid Plastische Chirurgie Medisch, CTI Eijkelkamp, Brain, Cancer, Child Health, Infection & Immunity, Brakkee, Elisabeth Maria, Devinney, Erick, Eijkelkamp, Niels, and Coert, J. Henk

Published
2023

30. Mesenchymal stem/stromal cells-derived extracellular vesicles as a potentially more beneficial therapeutic strategy than MSC-based treatment in a mild metabolic osteoarthritis model

Author

CS_Locomotion, Equine Musculoskeletal Biology, Warmink, Kelly, Rios, Jaqueline L, Varderidou-Minasian, Suzy, Torres-Torrillas, Marta, van Valkengoed, Devin R, Versteeg, Sabine, Eijkelkamp, Niels, Weinans, Harrie, Korthagen, Nicoline M, Lorenowicz, Magdalena J, CS_Locomotion, Equine Musculoskeletal Biology, Warmink, Kelly, Rios, Jaqueline L, Varderidou-Minasian, Suzy, Torres-Torrillas, Marta, van Valkengoed, Devin R, Versteeg, Sabine, Eijkelkamp, Niels, Weinans, Harrie, Korthagen, Nicoline M, and Lorenowicz, Magdalena J

Published
2023

31. Mesenchymal stem/stromal cells-derived extracellular vesicles as a potentially more beneficial therapeutic strategy than MSC-based treatment in a mild metabolic osteoarthritis model

Author

Warmink, Kelly (author), Rios, Jaqueline L. (author), Varderidou-Minasian, Suzy (author), Torres-Torrillas, Marta (author), van Valkengoed, Devin R. (author), Versteeg, Sabine (author), Eijkelkamp, Niels (author), Weinans, Harrie (author), Korthagen, Nicoline M. (author), Lorenowicz, Magdalena J. (author), Warmink, Kelly (author), Rios, Jaqueline L. (author), Varderidou-Minasian, Suzy (author), Torres-Torrillas, Marta (author), van Valkengoed, Devin R. (author), Versteeg, Sabine (author), Eijkelkamp, Niels (author), Weinans, Harrie (author), Korthagen, Nicoline M. (author), and Lorenowicz, Magdalena J. (author)

Abstract

Background: Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) hold promise as a disease modifying treatment in osteoarthritis (OA). Obesity, and its associated inflammation, contribute to OA development and metabolic OA represents a specific and significant group of the OA patient population. Given their immunomodulatory properties, MSC and MSC-EVs are especially interesting for this group of patients as a therapeutic option. Here, we were the first to compare the therapeutic efficacy of MSCs and MSC-EVs in a mild OA model taking these metabolic aspects into consideration. Methods: Male Wistar-Han rats (Crl:WI(Han) (n = 36) were fed a high fat diet for 24 weeks, with unilateral induction of OA by groove surgery after 12 weeks. Eight days after surgery rats were randomized in three treatment groups receiving MSCs, MSC-EVs or vehicle injection. Pain-associated behavior, joint degeneration, and local and systemic inflammation were measured. Results: We demonstrated that despite not having a significant therapeutic effect, MSC-EV treatment results in lower cartilage degeneration, less pain behaviour, osteophytosis and joint inflammation, than MSC treatment. Suggesting that MSC-EVs could be a more promising therapeutic strategy than MSCs in this mild metabolic OA model. Conclusion: In summary, we find that MSC treatment has negative effects on the joint in metabolic mild OA. This is an essential finding for the significant group of patients with metabolic OA phenotype, and might help to understand why clinical translation of MSC treatment shows varying therapeutic efficacy thus far. Our results also suggest that MSC-EV-based treatment might be a promising option for these patients, however MSC-EV therapeutic efficacy will need improvement., Biomaterials & Tissue Biomechanics

Published
2023
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32. Sustained release of locally delivered celecoxib provides pain relief for osteoarthritis: a proof of concept in dog patients

Author

Diagnostische beeldvorming, Chirurgie, CS_Cancer, CS_Locomotion, Equine Musculoskeletal Biology, Dep Clinical Sciences, Locomotion - Equine Sciences, Locomotion - Surgery (CA), OnGo, Tellegen, Anna R, Rudnik-Jansen, Imke, Utomo, Lizette, Versteeg, Sabine, Beukers, Martijn, Maarschalkerweerd, Roelof, van Zuilen, Dick, van Klaveren, Nicoline J, Houben, Kaat, Teske, Erik, René van Weeren, P, Karssemakers-Degen, Nina, Mihov, George, Thies, Jens, Eijkelkamp, Niels, Creemers, Laura B, Meij, Björn P, Tryfonidou, Marianna A, Diagnostische beeldvorming, Chirurgie, CS_Cancer, CS_Locomotion, Equine Musculoskeletal Biology, Dep Clinical Sciences, Locomotion - Equine Sciences, Locomotion - Surgery (CA), OnGo, Tellegen, Anna R, Rudnik-Jansen, Imke, Utomo, Lizette, Versteeg, Sabine, Beukers, Martijn, Maarschalkerweerd, Roelof, van Zuilen, Dick, van Klaveren, Nicoline J, Houben, Kaat, Teske, Erik, René van Weeren, P, Karssemakers-Degen, Nina, Mihov, George, Thies, Jens, Eijkelkamp, Niels, Creemers, Laura B, Meij, Björn P, and Tryfonidou, Marianna A

Published
2023

33. Inflammation-induced mitochondrial and metabolic disturbances in sensory neurons control the switch from acute to chronic pain

Author

CTI Eijkelkamp, Infection & Immunity, Cancer, Genetica Sectie Metabole Diagnostiek, Medische Fysiologie, Circulatory Health, Brain, Child Health, Willemen, HLDM, Silva Santos Ribeiro, Patrícia, Broeks, Melissa, Meijer, Nils, Versteeg, Sabine, Tiggeler, Annefien, de Boer, Teun, Małecki, Jędrzej, Falnes, Pål Ø, Jans, Judith, Eijkelkamp, Niels, CTI Eijkelkamp, Infection & Immunity, Cancer, Genetica Sectie Metabole Diagnostiek, Medische Fysiologie, Circulatory Health, Brain, Child Health, Willemen, HLDM, Silva Santos Ribeiro, Patrícia, Broeks, Melissa, Meijer, Nils, Versteeg, Sabine, Tiggeler, Annefien, de Boer, Teun, Małecki, Jędrzej, Falnes, Pål Ø, Jans, Judith, and Eijkelkamp, Niels

Published
2023

34. NLRP3 inflammasome activation in sensory neurons promotes chronic inflammatory and osteoarthritis pain

Author

CTI Eijkelkamp, Infection & Immunity, Pathologie Patiëntenadministratie, Cancer, Brain, Child Health, Silva Santos Ribeiro, Patrícia, Willemen, Hanneke L D M, Versteeg, Sabine, Martin Gil, Christian, Eijkelkamp, Niels, CTI Eijkelkamp, Infection & Immunity, Pathologie Patiëntenadministratie, Cancer, Brain, Child Health, Silva Santos Ribeiro, Patrícia, Willemen, Hanneke L D M, Versteeg, Sabine, Martin Gil, Christian, and Eijkelkamp, Niels

Published
2023

35. Human IAPP is a contributor to painful diabetic peripheral neuropathy

Author

CTI Eijkelkamp, Zorgeenheid Plastische Chirurgie Medisch, Brain, Cancer, Infection & Immunity, CTI, CMM Groep Burgering, Child Health, Albariqi, Mohammed Mh, Versteeg, Sabine, Brakkee, Elisabeth M, Coert, J Henk, Elenbaas, Barend Ow, Prado, Judith, Hack, C Erik, Höppener, Jo Wm, Eijkelkamp, Niels, CTI Eijkelkamp, Zorgeenheid Plastische Chirurgie Medisch, Brain, Cancer, Infection & Immunity, CTI, CMM Groep Burgering, Child Health, Albariqi, Mohammed Mh, Versteeg, Sabine, Brakkee, Elisabeth M, Coert, J Henk, Elenbaas, Barend Ow, Prado, Judith, Hack, C Erik, Höppener, Jo Wm, and Eijkelkamp, Niels

Published
2023

36. Mesenchymal stem/stromal cells-derived extracellular vesicles as a potentially more beneficial therapeutic strategy than MSC-based treatment in a mild metabolic osteoarthritis model

Author

ORT Research, CTI Eijkelkamp, Brain, Cancer, Child Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Orthopaedie Onderzoek, CMM, CMM Groep Coffer, Warmink, Kelly, Rios, Jaqueline L., Varderidou-Minasian, Suzy, Torres-Torrillas, Marta, van Valkengoed, Devin R., Versteeg, Sabine, Eijkelkamp, Niels, Weinans, Harrie, Korthagen, Nicoline M., Lorenowicz, Magdalena J., ORT Research, CTI Eijkelkamp, Brain, Cancer, Child Health, Infection & Immunity, Regenerative Medicine and Stem Cells, Orthopaedie Onderzoek, CMM, CMM Groep Coffer, Warmink, Kelly, Rios, Jaqueline L., Varderidou-Minasian, Suzy, Torres-Torrillas, Marta, van Valkengoed, Devin R., Versteeg, Sabine, Eijkelkamp, Niels, Weinans, Harrie, Korthagen, Nicoline M., and Lorenowicz, Magdalena J.

Published
2023

37. Effects of mesenchymal stem cells and heparan sulfate mimetics on urethral function and vaginal wall biomechanics in a simulated rat childbirth injury model

Author

MS VPG/Gynaecologie, Regenerative Medicine and Stem Cells, CTI Eijkelkamp, Brain, Cancer, Child Health, Infection & Immunity, Janssen, Kristine, van Ruiten, Geertruida W., Eijkelkamp, Niels, Damaser, Margot S., van der Vaart, Carl H., MS VPG/Gynaecologie, Regenerative Medicine and Stem Cells, CTI Eijkelkamp, Brain, Cancer, Child Health, Infection & Immunity, Janssen, Kristine, van Ruiten, Geertruida W., Eijkelkamp, Niels, Damaser, Margot S., and van der Vaart, Carl H.

Published
2023

38. Sustained release of locally delivered celecoxib provides pain relief for osteoarthritis: a proof of concept in dog patients

Author

Orthopaedie Onderzoek, MKA/BT Onderzoek, CTI Eijkelkamp, Brain, Child Health, Infection & Immunity, Cancer, ORT Research, Regenerative Medicine and Stem Cells, Tellegen, Anna R, Rudnik-Jansen, Imke, Utomo, Lizette, Versteeg, Sabine, Beukers, Martijn, Maarschalkerweerd, Roelof, van Zuilen, Dick, van Klaveren, Nicoline J, Houben, Kaat, Teske, Erik, René van Weeren, P, Karssemakers-Degen, Nina, Mihov, George, Thies, Jens, Eijkelkamp, Niels, Creemers, Laura B, Meij, Björn P, Tryfonidou, Marianna A, Orthopaedie Onderzoek, MKA/BT Onderzoek, CTI Eijkelkamp, Brain, Child Health, Infection & Immunity, Cancer, ORT Research, Regenerative Medicine and Stem Cells, Tellegen, Anna R, Rudnik-Jansen, Imke, Utomo, Lizette, Versteeg, Sabine, Beukers, Martijn, Maarschalkerweerd, Roelof, van Zuilen, Dick, van Klaveren, Nicoline J, Houben, Kaat, Teske, Erik, René van Weeren, P, Karssemakers-Degen, Nina, Mihov, George, Thies, Jens, Eijkelkamp, Niels, Creemers, Laura B, Meij, Björn P, and Tryfonidou, Marianna A

Published
2023

39. Additional file 1 of Mesenchymal stem/stromal cells-derived extracellular vesicles as a potentially more beneficial therapeutic strategy than MSC-based treatment in a mild metabolic osteoarthritis model

Author

Warmink, Kelly, Rios, Jaqueline L., Varderidou-Minasian, Suzy, Torres-Torrillas, Marta, van Valkengoed, Devin R., Versteeg, Sabine, Eijkelkamp, Niels, Weinans, Harrie, Korthagen, Nicoline M., and Lorenowicz, Magdalena J.

Abstract

Additional file 1: Fig. S1. Characterization of extracellular vesicles derived from human bone marrow MSCs. A MSC-EVs are positive for exosomal markers CD63 and CD9. EVs isolated from conditioned medium derived from primary bone marrow MSCs were subjected to sucrose density gradient followed by Western blot analysis for presence of CD63 and CD9. Representative Western-blots cropped at the molecular weight of CD63 and CD9 respectively are shown. B Nanosight Particle Tracking Analysis derived from 5 measurements showing that the nominal size of these vesicles is 125 nm. Red colour indicates error bar of the mean. Fig. S2. Inflammatory serum markers. Results of the 27 multiplex-assay showing all measured cytokines and chemokines from week 24 serum. One animal was excluded from multiplex analysis due to out of range values. Several EGF data points were excluded from analysis due to out of range values. Graphs represent mean ± 95% confidence interval, p values in graphs are reported with asterisks where p ≤ 0.05 is *, p ≤ 0.01 is **, p ≤ 0.001 is *** and p > 0.05 is not significant. Fig. S3. Body mass and metabolics. A Body mass between week 11 and 24 in the experimental protocol. B Body mass individual values at week 11 and C at week 24. Body mass increase as a percentage from week 11 in individual animals for D PBS, E MSCs and F MSC-EVs groups. G Homeostatic Model Assessment for Insulin Resistance, H triglyceride and I leptin concentrations. J Correlation between body mass and leptin concentration. Three animals were excluded from HOMA-IR analysis and one animal was excluded from leptin concentration analysis, due to out of range values. No animals or data points were excluded from all other analysis shown here, n = 12 per group. Graphs represent mean ± 95% confidence interval, p values in graphs are reported with asterisks where p ≤ 0.05 is *, p ≤ 0.01 is **, p ≤ 0.001 is *** and p > 0.05 is not significant. Fig. S4. Full length gels used in the Fig. S1A.

Published
2023
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45. Identifying disrupted biological factors and patient-tailored interventions for chronic fatigue in adolescents and young adults with Q-Fever Fatigue Syndrome, Chronic Fatigue Syndrome and Juvenile Idiopathic Arthritis (QFS-study): study protocol for a randomized controlled trial with single-subject experimental case series design

Author

Vroegindeweij, Anouk, primary, Swart, Joost F., additional, Houtveen, Jan, additional, Eijkelkamp, Niels, additional, De Putte, Elise M. Van, additional, Wulffraat, Nico M., additional, and Nijhof, Sanne L., additional

Published
2022
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46. Feasibility of quantitative sensory testing in juvenile idiopathic arthritis

Author

Immuno/reuma onderzoek 7 (Swart), CTI Eijkelkamp, Brain, Child Health, Infection & Immunity, Cancer, Immuno/reuma ERN, Mensink, Maarten O, Eijkelkamp, Niels, Veldhuijzen, Dieuwke S, Wulffraat, Nico M, Immuno/reuma onderzoek 7 (Swart), CTI Eijkelkamp, Brain, Child Health, Infection & Immunity, Cancer, Immuno/reuma ERN, Mensink, Maarten O, Eijkelkamp, Niels, Veldhuijzen, Dieuwke S, and Wulffraat, Nico M

Published
2022

47. Mitochondria and sensory processing in inflammatory and neuropathic pain

Author

CTI Eijkelkamp, Infection & Immunity, Brain, Child Health, Cancer, Silva Santos Ribeiro, P, Willemen, Hanneke L D M, Eijkelkamp, Niels, CTI Eijkelkamp, Infection & Immunity, Brain, Child Health, Cancer, Silva Santos Ribeiro, P, Willemen, Hanneke L D M, and Eijkelkamp, Niels

Published
2022

48. Identifying disrupted biological factors and patient-tailored interventions for chronic fatigue in adolescents and young adults with Q-Fever Fatigue Syndrome, Chronic Fatigue Syndrome and Juvenile Idiopathic Arthritis (QFS-study): study protocol for a randomized controlled trial with single-subject experimental case series design

Author

Immuno/reuma onderzoek 7 (Swart), Infection & Immunity, Immuno/reuma patientenzorg, Child Health, CTI Eijkelkamp, Brain, Cancer, Sociale pediatrie onderzoek 1, Regenerative Medicine and Stem Cells, Cluster B, Immuno/reuma ERN, Integrale & Alg. Kindergen Patientenzorg, Vroegindeweij, Anouk, Swart, Joost F., Houtveen, Jan, Eijkelkamp, Niels, van de Putte, Elise M., Wulffraat, Nico M., Nijhof, Sanne L., Immuno/reuma onderzoek 7 (Swart), Infection & Immunity, Immuno/reuma patientenzorg, Child Health, CTI Eijkelkamp, Brain, Cancer, Sociale pediatrie onderzoek 1, Regenerative Medicine and Stem Cells, Cluster B, Immuno/reuma ERN, Integrale & Alg. Kindergen Patientenzorg, Vroegindeweij, Anouk, Swart, Joost F., Houtveen, Jan, Eijkelkamp, Niels, van de Putte, Elise M., Wulffraat, Nico M., and Nijhof, Sanne L.

Published
2022

49. Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain

Author

CTI Eijkelkamp, CTI Van der Vlist, Infection & Immunity, Pathologie Opleiding, Cancer, Translational Neuroscience, Brain, Regenerative Medicine and Stem Cells, CTI, Child Health, van der Vlist, Michiel, Raoof, Ramin, Willemen, Hanneke L.D.M., Prado, Judith, Versteeg, Sabine, Martin Gil, Christian, Vos, Martijn, Lokhorst, Roeland E., Pasterkamp, R. Jeroen, Kojima, Toshiyuki, Karasuyama, Hajime, Khoury-Hanold, William, Meyaard, Linde, Eijkelkamp, Niels, CTI Eijkelkamp, CTI Van der Vlist, Infection & Immunity, Pathologie Opleiding, Cancer, Translational Neuroscience, Brain, Regenerative Medicine and Stem Cells, CTI, Child Health, van der Vlist, Michiel, Raoof, Ramin, Willemen, Hanneke L.D.M., Prado, Judith, Versteeg, Sabine, Martin Gil, Christian, Vos, Martijn, Lokhorst, Roeland E., Pasterkamp, R. Jeroen, Kojima, Toshiyuki, Karasuyama, Hajime, Khoury-Hanold, William, Meyaard, Linde, and Eijkelkamp, Niels

Published
2022

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