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Summary: Cancellations within 24 h of planned elective surgical procedures reduce operating theatre efficiency, add unnecessary costs and negatively affect patient experience. We implemented a bundle intervention that aimed to reduce same‐day case cancellations. This consisted of communication tools to improve patient engagement and new screening instruments (automated estimation of ASA physical status and case cancellation risk score plus four screening questions) to identify patients in advance (ideally before case booking) who needed comprehensive pre‐operative risk stratification. We studied patients scheduled for ambulatory surgery with the otorhinolaryngology service at a single centre from April 2021 to December 2022. Multivariable logistic regression and interrupted time‐series analyses were used to analyse the effects of this intervention on case cancellations within 24 h and costs. We analysed 1548 consecutive scheduled cases. Cancellation within 24 h occurred in 114 of 929 (12.3%) cases pre‐intervention and 52 of 619 (8.4%) cases post‐intervention. The cancellation rate decreased by 2.7% (95%CI 1.6–3.7%, p < 0.01) during the first month, followed by a monthly decrease of 0.2% (95%CI 0.1–0.4%, p < 0.01). This resulted in an estimated $150,200 (£118,755; €138,370) or 35.3% cost saving (p < 0.01). Median (IQR [range]) number of days between case scheduling and day of surgery decreased from 34 (21–61 [0–288]) pre‐intervention to 31 (20–51 [1–250]) post‐intervention (p < 0.01). Patient engagement via the electronic health record patient portal or text messaging increased from 75.9% at baseline to 90.8% (p < 0.01) post‐intervention. The primary reason for case cancellation was patients' missed appointment on the day of surgery, which decreased from 7.2% pre‐intervention to 4.5% post‐intervention (p = 0.03). An anaesthetist‐driven, clinical informatics‐based bundle intervention decreases same‐day case cancellation rate and associated costs in patients scheduled for ambulatory otorhinolaryngology surgery. [ABSTRACT FROM AUTHOR]

Summary: Reversing neuromuscular blockade with sugammadex can eliminate residual paralysis, which has been associated with postoperative respiratory complications. There are equivocal data on whether sugammadex reduces these when compared with neostigmine. We investigated the association of the choice of reversal drug with postoperative respiratory complications and advanced healthcare utilisation. We included adult patients who underwent surgery and received general anaesthesia with sugammadex or neostigmine reversal at two academic healthcare networks between January 2016 and June 2021. The primary outcome was postoperative respiratory complications, defined as post‐extubation oxygen saturation < 90%, respiratory failure requiring non‐invasive ventilation, or tracheal re‐intubation within 7 days. Our main secondary outcome was advanced healthcare utilisation, a composite outcome including: 7‐day unplanned intensive care unit admission; 30‐day hospital readmission; or non‐home discharge. In total, 5746 (6.9%) of 83,250 included patients experienced postoperative respiratory complications. This was not associated with the reversal drug (adjusted OR (95%CI) 1.01 (0.94–1.08); p = 0.76). After excluding patients admitted from skilled nursing facilities, 8372 (10.5%) patients required advanced healthcare utilisation, which was not associated with the choice of reversal (adjusted OR (95%CI) 0.95 (0.89–1.01); p = 0.11). Equivalence testing supported an equivalent effect size of sugammadex and neostigmine on both outcomes, and neostigmine was non‐inferior to sugammadex with regard to postoperative respiratory complications or advanced healthcare utilisation. Finally, there was no association between the reversal drug and major adverse cardiovascular events (adjusted OR 1.07 (0.94–1.21); p = 0.32). Compared with neostigmine, reversal of neuromuscular blockade with sugammadex was not associated with a reduction in postoperative respiratory complications or post‐procedural advanced healthcare utilisation. [ABSTRACT FROM AUTHOR]