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1. Degree of hydrolysis is a poor predictor of the sensitizing capacity of whey- and casein-based hydrolysates in a Brown Norway rat model of cow’s milk allergy

Author: Bøgh, Katrine Lindholm, Nielsen, Ditte Møller, Mohammad-Beigi, Hossein, Christoffersen, Heidi Frahm, Jacobsen, Lotte Neergaard, Norrild, Rasmus Krogh, Svensson, Birte, Schmidthaler, Klara, Szépfalusi, Zsolt, Upton, Julia, Eiwegger, Thomas, Bertelsen, Hans, Buell, Alexander Kai, Sørensen, Laila Vestergaard, and Larsen, Jeppe Madura
Published: 2024
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2. Assessing Pediatric Cephalosporin Allergic Reactions Through Direct Graded Oral Challenges

Author: Sillcox, Carly, Gabrielli, Sofianne, O’Keefe, Andrew, McCusker, Christine, Abrams, Elissa M., Eiwegger, Thomas, Atkinson, Adelle, Kim, Vy, Copaescu, Ana-Maria, and Ben-Shoshan, Moshe
Published: 2024
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3. European Respiratory Society Statement on preschool wheezing disorders: updated definitions, knowledge gaps, and proposed future research directions

Author: Makrinioti, Heidi, primary, Fainardi, Valentina, additional, Bonnelykke, Klaus, additional, Custovic, Adnan, additional, Cicutto, Lisa, additional, Coleman, Courtney, additional, Eiwegger, Thomas, additional, Kuehni, Claudia, additional, Moeller, Alexander, additional, Pedersen, Eva, additional, Pijnenburg, Marielle, additional, Pinnock, Hilary, additional, Ranganathan, Sarath, additional, Tonia, Thomy, additional, Subbarao, Padmaja, additional, and Saglani, Sejal, additional
Published: 2024
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4. Food protein-induced enterocolitis syndrome in a tertiary pediatric center: safety of guideline-conforming food challenges

Author: Samantha Wong, Lucy Duan, Alana Galper, Adelle Atkinson, Julia Upton, and Thomas Eiwegger
Subjects: FPIES, Food allergy, Oral food challenges, Non-IgE allergy, Immunologic diseases. Allergy, RC581-607
Abstract: Abstract Food protein-induced enterocolitis syndrome is a non-IgE-mediated reaction to food that is poorly understood, and underdiagnosed. Trigger foods can belong to any food group, but are most commonly milk, soy, rice, oat, egg, and fish. In this retrospective study (2015–2020), we describe the clinical presentations and triggers of 37 children referred to tertiary hospital with a confirmed or suspected diagnosis of food protein-inducted enterocolitis. We reviewed the safety of current recommendations by looking at the outcome of 24 oral food challenges. All of these patients presented with clear cut systemic reactions including lethargy. We also assessed the severity of the reactions. Oral food challenges occurred in the hospital day unit with the majority of patients having IV access in place. Despite a clear history of FPIES with lethargy and the requirement for re-hydration of the challenged population, 21/24 (88%) of the FPIES OFCs were successful. Of the three patients who reacted, symptoms were of moderate nature, mainly vomiting. This highlights the importance of early diagnosis and a pro-active approach to performing guideline-directed oral food challenges in patients with food protein-induced enterocolitis syndrome.
Published: 2022
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5. Food protein-induced enterocolitis syndrome in a tertiary pediatric center: safety of guideline-conforming food challenges

Author: Wong, Samantha, Duan, Lucy, Galper, Alana, Atkinson, Adelle, Upton, Julia, and Eiwegger, Thomas
Published: 2022
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6. Degree of hydrolysis is a poor predictor of the sensitizing capacity of whey- and casein-based hydrolysates in a Brown Norway rat model of cow’s milk allergy

Author: Lindholm Bøgh, Katrine, primary, Møller Nielsen, Ditte, additional, Mohammad-Beigi, Hossein, additional, Frahm Christoffersen, Heidi, additional, Neergaard Jacobsen, Lotte, additional, Krogh Norrild, Rasmus, additional, Svensson, Birte, additional, Schmidthaler, Klara, additional, Szépfalusi, Zsolt, additional, Upton, Julia, additional, Eiwegger, Thomas, additional, Bertelsen, Hans, additional, Kai Buell, Alexander, additional, Vestergaard Sørensen, Laila, additional, and Madura Larsen, Jeppe, additional
Published: 2024
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7. Establishing Amoxicillin Allergy in Children Through Direct Graded Oral Challenge (GOC): Evaluating Risk Factors for Positive Challenges, Safety, and Risk of Cross-Reactivity to Cephalosporines

Author: Exius, Rutherford, Gabrielli, Sofianne, Abrams, Elissa M., O'Keefe, Andrew, Protudjer, Jennifer L.P., Lavine, Elana, Pitt, Tracy, Atkinson, Adelle, Eiwegger, Thomas, McCusker, Christine, and Ben-Shoshan, Moshe
Published: 2021
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8. Immunologically relevant aspects of the new COVID-19 vaccines—an ÖGAI (Austrian Society for Allergology and Immunology) and AeDA (German Society for Applied Allergology) position paper

Author: Untersmayr, Eva, Förster-Waldl, Elisabeth, Bonelli, Michael, Boztug, Kaan, Brunner, Patrick M., Eiwegger, Thomas, Eller, Kathrin, Göschl, Lisa, Grabmeier-Pfistershammer, Katharina, Hötzenecker, Wolfram, Jordakieva, Galateja, Moschen, Alexander R., Pfaller, Birgit, Pickl, Winfried, Reinisch, Walter, Wiedermann, Ursula, Klimek, Ludger, Bergmann, Karl-Christian, Brehler, Randolf, Pfützner, Wolfgang, Novak, Natalija, Merk, Hans, Rabe, Uta, Schlenter, Wolfgang, Ring, Johannes, Wehrmann, Wolfgang, Mülleneisen, Norbert, Wrede, Holger, Fuchs, Thomas, and Jensen-Jarolim, Erika
Published: 2021
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9. Differentiating Between β-Lactam-Induced Serum Sickness–Like Reactions and Viral Exanthem in Children Using a Graded Oral Challenge

Author: Delli Colli, Luca, Gabrielli, Sofianne, Abrams, Elissa M., O'Keefe, Andrew, Protudjer, Jennifer L.P., Lavine, Elana, Pitt, Tracy, Atkinson, Adelle, Eiwegger, Thomas, McCusker, Christine, and Ben-Shoshan, Moshe
Published: 2021
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10. Degree of hydrolysis is a poor predictor of the sensitizing capacity of whey- and casein-based hydrolysates in a Brown Norway rat model of cow’s milk allergy

Author: Lindholm Bøgh, Katrine, Møller Nielsen, Ditte, Mohammad-Beigi, Hossein, Frahm Christoffersen, Heidi, Neergaard Jacobsen, Lotte, Krogh Norrild, Rasmus, Svensson, Birte, Schmidthaler, Klara, Szépfalusi, Zsolt, Upton, Julia, Eiwegger, Thomas, Bertelsen, Hans, Kai Buell, Alexander, Vestergaard Sørensen, Laila, Madura Larsen, Jeppe, Lindholm Bøgh, Katrine, Møller Nielsen, Ditte, Mohammad-Beigi, Hossein, Frahm Christoffersen, Heidi, Neergaard Jacobsen, Lotte, Krogh Norrild, Rasmus, Svensson, Birte, Schmidthaler, Klara, Szépfalusi, Zsolt, Upton, Julia, Eiwegger, Thomas, Bertelsen, Hans, Kai Buell, Alexander, Vestergaard Sørensen, Laila, and Madura Larsen, Jeppe
Abstract: The use of infant formulas (IFs) based on hydrolyzed cow’s milk proteins to prevent cow’s milk allergy (CMA) is highly debated. The risk of sensitization to milk proteins induced by IFs may be affected by the degree of hydrolysis (DH) as well as other physicochemical properties of the cow’s milk-based protein hydrolysates within the IFs. The immunogenicity (specific IgG1 induction) and sensitizing capacity (specific IgE induction) of 30 whey- or casein-based hydrolysates with different physicochemical characteristics were compared using an intraperitoneal model of CMA in Brown Norway rats. In general, the whey-based hydrolysates demonstrated higher immunogenicity than casein-based hydrolysates, inducing higher levels of hydrolysate-specific and intact-specific IgG1. The immunogenicity of the hydrolysates was influenced by DH, peptide size distribution profile, peptide aggregation, nano-sized particle formation, and surface hydrophobicity. Yet, only the surface hydrophobicity was found to affect the sensitizing capacity of hydrolysates, as high hydrophobicity was associated with higher levels of specific IgE. The whey- and casein-based hydrolysates exhibited distinct immunological properties with highly diverse molecular composition and physicochemical properties which are not accounted for by measuring DH, which was a poor predictor of sensitizing capacity. Thus, future studies should consider and account for physicochemical characteristics when assessing the sensitizing capacity of cow’s milk-based protein hydrolysates.
Published: 2024

11. Does the Use of the 'Proseek® Multiplex Inflammation I Panel' Demonstrate a Difference in Local and Systemic Immune Responses in Endometriosis Patients with or without Deep-Infiltrating Lesions?

Author: Alexandra Perricos, Heinrich Husslein, Lorenz Kuessel, Manuela Gstoettner, Andreas Weinhaeusel, Thomas Eiwegger, Gabriel Beikircher, and René Wenzl
Subjects: endometriosis, inflammation, multiplex analysis, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract: Endometriotic lesions are able to infiltrate surrounding tissue. This is made possible partly by an altered local and systemic immune response that helps achieve neoangiogenesis, cell proliferation and immune escape. Deep-infiltrating endometriosis (DIE) differs from other subtypes through the invasion of its lesions over 5 mm into affected tissue. Despite the invasive nature of these lesions and the wider range of symptoms they can trigger, DIE is described as a stable disease. This elicits the need for a better understanding of the underlying pathogenesis. We used the “Proseek® Multiplex Inflammation I Panel” in order to simultaneously detect 92 inflammatory proteins in plasma and peritoneal fluid (PF) of controls and patients with endometriosis, as well as in particular patients with DIE, in order to gain a better insight into the systemically and locally involved immune response. Extracellular newly identified receptor for advanced gycation end-products binding protein (EN-RAGE), C-C motif Chemokine ligand 23 (CCL23), Eukaryotic translation initiation factor 4—binding protein 1 (4E-BP1) and human glial cell-line derived neurotrophic factor (hGDNF) were significantly increased in plasma of endometriosis patients compared to controls, whereas Hepatocyte Growth factor (HGF) and TNF-related apoptosis inducing ligand (TRAIL) were decreased. In PF of endometriosis patients, we found Interleukin 18 (IL-18) to be decreased, yet Interleukin 8 (IL-8) and Interleukin 6 (IL-6) to be increased. TNF-related activation-induced cytokine (TRANCE) and C-C motif Chemokine ligand 11 (CCL11) were significantly decreased in plasma, whereas C-C motif Chemokine ligand 23 (CCL23), Stem Cell Factor (SCF) and C-X-C motif chemokine 5 (CXCL5) were significantly increased in PF of patients with DIE compared to endometriosis patients without DIE. Although DIE lesions are characterized by increased angiogenetic and pro-inflammatory properties, our current study seems to support the theory that the systemic immune system does not play a major role in the pathogenesis of these lesions.
Published: 2023
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12. Improving "may contain" labels: A call to team up and share data.

Author: Turner, Paul J. and Eiwegger, Thomas
Subjects: *MILK allergy, *INFORMATION sharing
Abstract: The article discusses the use of precautionary allergen labeling (PAL) in the food industry and the need for a regulated approach to assessing unintended allergen presence (UAP). It emphasizes the importance of accurate risk assessment and the need for further research in this area. The article also discusses the interpretation and implications of data on allergen thresholds for individuals with food allergies, cautioning that estimates for the proportion of allergic individuals who may react to very low doses of allergens should be interpreted with caution due to limited data at these levels. The text suggests alternative approaches, such as single-dose oral food challenges, to validate these estimates and highlights the potential benefits of individualized allergen management based on a patient's threshold. It addresses concerns about the applicability of oral food challenge data to real-world exposures and the impact of food processing on allergenicity. The article concludes by calling for the sharing of standardized oral food challenge datasets to inform allergen risk management. [Extracted from the article]
Published: 2024
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13. Toward personalization of asthma treatment according to trigger factors

Author: Niespodziana, Katarzyna, Borochova, Kristina, Pazderova, Petra, Schlederer, Thomas, Astafyeva, Natalia, Baranovskaya, Tatiana, Barbouche, Mohamed-Ridha, Beltyukov, Evgeny, Berger, Angelika, Borzova, Elena, Bousquet, Jean, Bumbacea, Roxana S., Bychkovskaya, Snezhana, Caraballo, Luis, Chung, Kian Fan, Custovic, Adnan, Docena, Guillermo, Eiwegger, Thomas, Evsegneeva, Irina, Emelyanov, Alexander, Errhalt, Peter, Fassakhov, Rustem, Fayzullina, Rezeda, Fedenko, Elena, Fomina, Daria, Gao, Zhongshan, Giavina-Bianchi, Pedro, Gotua, Maia, Greber-Platzer, Susanne, Hedlin, Gunilla, Ilina, Natalia, Ispayeva, Zhanat, Idzko, Marco, Johnston, Sebastian L., Kalayci, Ömer, Karaulov, Alexander, Karsonova, Antonina, Khaitov, Musa, Kovzel, Elena, Kowalski, Marek L., Kudlay, Dmitry, Levin, Michael, Makarova, Svetlana, Matricardi, Paolo Maria, Nadeau, Kari C., Namazova-Baranova, Leyla, Naumova, Olga, Nazarenko, Oleksandr, O’Byrne, Paul M., Osier, Faith, Pampura, Alexander N., Panaitescu, Carmen, Papadopoulos, Nikolaos G., Park, Hae-Sim, Pawankar, Ruby, Pohl, Wolfgang, Renz, Harald, Riabova, Ksenja, Sampath, Vanitha, Sekerel, Bülent E., Sibanda, Elopy, Siroux, Valérie, Sizyakina, Ludmila P., Sun, Jin-Lyu, Szepfalusi, Zsolt, Umanets, Tetiana, Van Bever, Hugo P.S., van Hage, Marianne, Vasileva, Margarita, von Mutius, Erika, Wang, Jiu-Yao, Wong, Gary W.K., Zaikov, Sergii, Zidarn, Mihaela, and Valenta, Rudolf
Published: 2020
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14. Phase 3 Trial of Epicutaneous Immunotherapy in Toddlers with Peanut Allergy

Author: Matthew Greenhawt, Sayantani B. Sindher, Julie Wang, Michael O’Sullivan, George du Toit, Edwin H. Kim, Deborah Albright, Sara Anvari, Nicolette Arends, Peter D. Arkwright, Philippe Bégin, Katharina Blumchen, Thierry Bourrier, Terri Brown-Whitehorn, Heather Cassell, Edmond S. Chan, Christina E. Ciaccio, Antoine Deschildre, Amandine Divaret-Chauveau, Stacy L. Dorris, Morna J. Dorsey, Thomas Eiwegger, Michel Erlewyn-Lajeunesse, David M. Fleischer, Lara S. Ford, Maria Garcia-Lloret, Lisa Giovannini-Chami, Jonathan O. Hourihane, Nicola Jay, Stacie M. Jones, Leigh Ann Kerns, Kirsten M. Kloepfer, Stephanie Leonard, Guillaume Lezmi, Jay A. Lieberman, Jeanne Lomas, Melanie Makhija, Christopher Parrish, Jane Peake, Kirsten P. Perrett, Daniel Petroni, Wolfgang Pfützner, Jacqueline A. Pongracic, Patrick Quinn, Rachel G. Robison, Georgiana Sanders, Lynda Schneider, Hemant P. Sharma, Juan Trujillo, Paul J. Turner, Katherine Tuttle, Julia E. Upton, Pooja Varshney, Brian P. Vickery, Christian Vogelberg, Brynn Wainstein, Robert A. Wood, Katharine J. Bee, Dianne E. Campbell, Todd D. Green, Rihab Rouissi, Aurélie Peillon, Henry T. Bahnson, Timothée Bois, Hugh A. Sampson, A. Wesley Burks, and Pediatrics
Subjects: General Medicine
Abstract: Background No approved treatment for peanut allergy exists for children younger than 4 years of age, and the efficacy and safety of epicutaneous immunotherapy with a peanut patch in toddlers with peanut allergy are unknown. Methods We conducted this phase 3, multicenter, double-blind, randomized, placebo-controlled trial involving children 1 to 3 years of age with peanut allergy confirmed by a double-blind, placebo-controlled food challenge. Patients who had an eliciting dose (the dose necessary to elicit an allergic reaction) of 300 mg or less of peanut protein were assigned in a 2:1 ratio to receive epicutaneous immunotherapy delivered by means of a peanut patch (intervention group) or to receive placebo administered daily for 12 months. The primary end point was a treatment response as measured by the eliciting dose of peanut protein at 12 months. Safety was assessed according to the occurrence of adverse events during the use of the peanut patch or placebo. Results Of the 362 patients who underwent randomization, 84.8% completed the trial. The primary efficacy end point result was observed in 67.0% of children in the intervention group as compared with 33.5% of those in the placebo group (risk difference, 33.4 percentage points; 95% confidence interval, 22.4 to 44.5; P
Published: 2023

15. EAACI guidelines on the diagnosis of IgE‐mediated food allergy

Author: Santos, Alexandra F., primary, Riggioni, Carmen, additional, Agache, Ioana, additional, Akdis, Cezmi A., additional, Akdis, Mubeccel, additional, Alvarez‐Perea, Alberto, additional, Alvaro‐Lozano, Montserrat, additional, Ballmer‐Weber, Barbara, additional, Barni, Simona, additional, Beyer, Kirsten, additional, Bindslev‐Jensen, Carsten, additional, Brough, Helen A., additional, Buyuktiryaki, Betul, additional, Chu, Derek, additional, Del Giacco, Stefano, additional, Dunn‐Galvin, Audrey, additional, Eberlein, Bernadette, additional, Ebisawa, Motohiro, additional, Eigenmann, Philippe, additional, Eiwegger, Thomas, additional, Feeney, Mary, additional, Fernandez‐Rivas, Montserrat, additional, Fisher, Helen R., additional, Fleischer, David M., additional, Giovannini, Mattia, additional, Gray, Claudia, additional, Hoffmann‐Sommergruber, Karin, additional, Halken, Susanne, additional, Hourihane, Jonathan O’B., additional, Jones, Christina J., additional, Jutel, Marek, additional, Knol, Edward, additional, Konstantinou, George N., additional, Lack, Gideon, additional, Lau, Susanne, additional, Marques Mejias, Andreina, additional, Marchisotto, Mary Jane, additional, Meyer, Rosan, additional, Mortz, Charlotte G., additional, Moya, Beatriz, additional, Muraro, Antonella, additional, Nilsson, Caroline, additional, Lopes de Oliveira, Lucila Camargo, additional, O’Mahony, Liam, additional, Papadopoulos, Nikolaos G., additional, Perrett, Kirsten, additional, Peters, Rachel L., additional, Podesta, Marcia, additional, Poulsen, Lars K., additional, Roberts, Graham, additional, Sampson, Hugh A., additional, Schwarze, Jürgen, additional, Smith, Peter, additional, Tham, Elizabeth Huiwen, additional, Untersmayr, Eva, additional, Van Ree, Ronald, additional, Venter, Carina, additional, Vickery, Brian P., additional, Vlieg‐Boerstra, Berber, additional, Werfel, Thomas, additional, Worm, Margitta, additional, Du Toit, George, additional, and Skypala, Isabel, additional
Published: 2023
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16. Modes of Infant Feeding and the Risk of Childhood Asthma: A Prospective Birth Cohort Study

Author: Daley, Denise, Silverman, Frances, Hayglass, Kent, Kobor, Michael, Turvey, Stuart, Kollmann, Tobias, Brook, Jeff, Ramsey, Clare, Macri, Joseph, Sandford, Andrew, Pare, Peter, Tebbutt, Scott, Brauer, Michael, Denburg, Judah, Cyr, Michael, Kozyrskyj, Anita, Becker, Allan, Chen, Edith, Miller, Greg, Takaro, Tim, Ratjen, Felix, Grasemann, Hartmut, Dell, Sharon, To, Teresa, Moraes, Theo, Subbarao, Padmaja, Holness, Linn, Befus, A. Dean, Mandhane, Piushkumar, Laprise, Catherine, Scott, James, Hegele, Richard, Lou, Wendy, Anand, Sonia, Sears, Malcolm, Simons, Elinor, Azad, Meghan, Eiwegger, Thomas, Duan, Qingling, Hystad, Perry, Scott, Jeremy, Klopp, Annika, Vehling, Lorena, Becker, Allan B., Mandhane, Piushkumar J., Turvey, Stuart E., Lefebvre, Diana L., Sears, Malcolm R., and Azad, Meghan B.
Published: 2017
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17. The artificial intelligence (AI) revolution: How important for scientific work and its reliable sharing

Author: Jutel, Marek, primary, Zemelka‐Wiacek, Magdalena, additional, Ordak, Michal, additional, Pfaar, Oliver, additional, Eiwegger, Thomas, additional, Rechenmacher, Maximilian, additional, and Akdis, Cezmi A., additional
Published: 2023
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18. An update on recent developments and highlights in food allergy

Author: Locke, Arielle, primary, Hung, Lisa, additional, Upton, Julia E. M., additional, O'Mahony, Liam, additional, Hoang, Jennifer, additional, and Eiwegger, Thomas, additional
Published: 2023
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19. Phase 3 Trial of Epicutaneous Immunotherapy in Toddlers with Peanut Allergy

Author: Greenhawt, Matthew, primary, Sindher, Sayantani B., additional, Wang, Julie, additional, O’Sullivan, Michael, additional, du Toit, George, additional, Kim, Edwin H., additional, Albright, Deborah, additional, Anvari, Sara, additional, Arends, Nicolette, additional, Arkwright, Peter D., additional, Bégin, Philippe, additional, Blumchen, Katharina, additional, Bourrier, Thierry, additional, Brown-Whitehorn, Terri, additional, Cassell, Heather, additional, Chan, Edmond S., additional, Ciaccio, Christina E., additional, Deschildre, Antoine, additional, Divaret-Chauveau, Amandine, additional, Dorris, Stacy L., additional, Dorsey, Morna J., additional, Eiwegger, Thomas, additional, Erlewyn-Lajeunesse, Michel, additional, Fleischer, David M., additional, Ford, Lara S., additional, Garcia-Lloret, Maria, additional, Giovannini-Chami, Lisa, additional, Hourihane, Jonathan O., additional, Jay, Nicola, additional, Jones, Stacie M., additional, Kerns, Leigh Ann, additional, Kloepfer, Kirsten M., additional, Leonard, Stephanie, additional, Lezmi, Guillaume, additional, Lieberman, Jay A., additional, Lomas, Jeanne, additional, Makhija, Melanie, additional, Parrish, Christopher, additional, Peake, Jane, additional, Perrett, Kirsten P., additional, Petroni, Daniel, additional, Pfützner, Wolfgang, additional, Pongracic, Jacqueline A., additional, Quinn, Patrick, additional, Robison, Rachel G., additional, Sanders, Georgiana, additional, Schneider, Lynda, additional, Sharma, Hemant P., additional, Trujillo, Juan, additional, Turner, Paul J., additional, Tuttle, Katherine, additional, Upton, Julia E., additional, Varshney, Pooja, additional, Vickery, Brian P., additional, Vogelberg, Christian, additional, Wainstein, Brynn, additional, Wood, Robert A., additional, Bee, Katharine J., additional, Campbell, Dianne E., additional, Green, Todd D., additional, Rouissi, Rihab, additional, Peillon, Aurélie, additional, Bahnson, Henry T., additional, Bois, Timothée, additional, Sampson, Hugh A., additional, and Burks, A. Wesley, additional
Published: 2023
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20. Introducing peanut early in life – Ready for the general population?

Author: Zsolt Szépfalusi and Thomas Eiwegger
Subjects: Immunology, Immunology and Allergy
Published: 2023

21. Oral immunotherapy for food allergy: What's age got to do with it?

Author: Julia E. M. Upton, Natasha Correa, and Thomas Eiwegger
Subjects: Immunology, Immunology and Allergy
Published: 2023

22. Correction to: Protocol for a double-blind, randomized controlled trial on the dose-related efficacy of omalizumab in multi-food oral immunotherapy

Author: Langlois, Alexandra, Lavergne, Marie-Hélène, Leroux, Hélène, Killer, Kerstin, Azzano, Pauline, Paradis, Louis, Samaan, Kathryn, Lacombe-Barrios, Jonathan, Eiwegger, Thomas, Upton, Julia, Sussman, Gordon, Poder, Thomas, Mâsse, Benoît, Roches, Anne Des, and Bégin, Philippe
Published: 2020
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23. Protocol for a double-blind, randomized controlled trial on the dose-related efficacy of omalizumab in multi-food oral immunotherapy

Author: Langlois, Alexandra, Lavergne, Marie-Hélène, Leroux, Hélène, Killer, Kerstin, Azzano, Pauline, Paradis, Louis, Samaan, Kathryn, Lacombe-Barrios, Jonathan, Eiwegger, Thomas, Upton, Julia, Sussman, Gordon, Poder, Thomas, Mâsse, Benoît, Des Roches, Anne, and Bégin, Philippe
Published: 2020
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24. An update on recent developments and highlights in food allergy

Author: Arielle Locke, Lisa Hung, Julia Upton, Liam O'Mahony, Jennifer Hoang, and Thomas Eiwegger
Subjects: Immunology, Immunology and Allergy
Abstract: While both the incidence and general awareness of food allergies is increasing, the variety and clinical availability of therapeutics remain limited. Therefore, investigations into the potential factors contributing to the development of food allergy and the mechanisms of natural tolerance or induced desensitization are required. In addition, a detailed understanding of the pathophysiology of food allergies is needed to generate compelling, enduring, and safe treatment options. New findings regarding the contribution of barrier function, the effect of emollient interventions, mechanisms of allergen recognition, and the contributions of specific immune cell subsets through rodent models and human clinical studies provide novel insights. With the first approved treatment for peanut allergy, the clinical management of food allergy is evolving towards less intensive, alternative approaches involving fixed doses, lower maintenance dose targets, co-administration of biologicals, adjuvants, and tolerance-inducing formulations. The ultimate goal is to improve immunotherapy and develop precision-based medicine via risk phenotyping allowing optimal treatment for each food-allergic patient.
Published: 2023

25. A distinct microbiota composition is associated with protection from food allergy in an oral mouse immunization model

Author: Diesner, Susanne C., Bergmayr, Cornelia, Pfitzner, Barbara, Assmann, Vera, Krishnamurthy, Durga, Starkl, Philipp, Endesfelder, David, Rothballer, Michael, Welzl, Gerhard, Rattei, Thomas, Eiwegger, Thomas, Szépfalusi, Zsolt, Fehrenbach, Heinz, Jensen-Jarolim, Erika, Hartmann, Anton, Pali-Schöll, Isabella, and Untersmayr, Eva
Published: 2016
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26. Allergen-Specific T Cells in IgE-Mediated Food Allergy

Author: Saidova, Aziza, Hershkop, Ahuva Magder, Ponce, Marta, and Eiwegger, Thomas
Published: 2018
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27. Abstracts from the Food Allergy and Anaphylaxis Meeting 2016

Author: Guillaume Pouessel, Claire Claverie, Julien Labreuche, Jean-Marie Renaudin, Aimée Dorkenoo, Mireille Eb, Anne Moneret-Vautrin, Antoine Deschildre, Stephane Leteurtre, Linus Grabenhenrich, Margitta Worm, Sabine Dölle, Kathrin Scherer, Isidor Hutteger, Morten Christensen, Carsten Bindslev-Jensen, Charlotte Mortz, Esben Eller, Henrik Fomsgaard Kjaer, Leonor Carneiro-Leão, Jenny Badas, Alice Coimbra, Dikla Pivko Levy, Moshe Ben-Shoshan, Ayelet Rimon, Shira Benor, Nicolette J. T. Arends, Nikki Edelbroek, Hans de Groot, Joyce A. M. Emons, H. Kim A. Brand, Dirk Verhoeven, Leonieke N. van Veen, Nicolette W. de Jong, Geunwoong Noh, Eun Ha Jang, Mariona Pascal, Olga Dominguez, Mònica Piquer, Montserrat Alvaro, Rosa Jimenez-Feijoo, Jaime Lozano, Adriana Machinena, Maria del Mar Folqué, Maria Teresa Giner, Ana María Plaza, Paul Turner, Nandinee Patel, Marta Vazquez-Ortiz, Sarah Lindsley, Lucy Walker, Simon Rosenberg, Adriano Mari, Claudia Alessandri, Ivana Giangrieco, Lisa Tuppo, Chiara Rafaiani, Georg Mitterer, Michela Ciancamerla, Rosetta Ferrara, Maria Livia Bernardi, Danila Zennaro, Maurizio Tamburrini, Maria Antonetta Ciardiello, Christian Harwanegg, Antonio Fernandez, Regina Selb, Philippe Egenmann, Michelle Epstein, Karin Hoffmann-Sommergruber, Frits Koning, Martinus Lovik, E. N. Clare Mills, Javier Moreno, Henk van Loveren, Jean-Michel Wal, Susanne Diesner, Cornelia Bergmayr, Barbara Pfitzner, Vera Elisabeth Assmann, Philipp Starkl, David Endesfelder, Thomas Eiwegger, Zsolt Szepfalusi, Heinz Fehrenbach, Erika Jensen-Jarolim, Anton Hartmann, Isabella Pali-Schöll, Eva Untersmayr, Soren Wille, Peter Meyer, Caroline Klingebiel, Jonas Lidholm, Angelica Ehrenberg, Jonas Östling, Isabelle Cleach, Jean-Louis Mège, Joana Vitte, Roberta Aina, Pawel Dubiela, Sabine Pfeifer, Merima Bublin, Christian Radauer, Piotr Humeniuk, Stefan Kabasser, Riccardo Asero, Gador Bogas, Francisca Gomez, Paloma Campo, Maria Salas, Inmaculada Doña, Esther Barrionuevo, Maria Auxiliadora Guerrero, Cristobalina Mayorga, Ana Prieto, Domingo Barber, Maria Jose Torres, Annette Jamin, Andrea Wangorsch, Barbara Ballmer, Stefan Vieths, Stephan Scheurer, Danijela Apostolovic, Jelena Mihailovic, Maja Krstic, Maria Starkhammar, Tanja Cirkovic Velickovic, Carl Hamsten, Marianne van Hage, Francine C. van Erp, Edward F. Knol, Hannah M. Kansen, Bo Pontoppidan, Yolanda Meijer, Cornelis K. van der Ent, André C. Knulst, Rebekah Sayers, Helen Brown, Adnan Custovic, Angela Simpson, Claire Mills, Juliane Schulz, Network for Online Registration of Anaphylaxis (NORA), Jaap Akkerdaas, Muriel Totis, Annabelle Capt, Corinne Herouet-Guicheney, Ronald van Ree, Tushar Banerjee, Antima Banerjee, Mathilde Claude, Grégory Bouchaud, Roberta Lupi, Laure Castan, Olivier Tranquet, Sandra Denery-Papini, Marie Bodinier, Chantal Brossard, Rosella De Poi, Elisa Gritti, Emiliano De Dominicis, Bert Popping, Patrizia Polverino de Laureto, Kati Palosuo, Anna Kaarina Kukkonen, Anna Pelkonen, Mika Mäkelä, Nanju Alice Lee, Johanna Rost, Sridevi Muralidharan, Dianne Campbell, Sam Mehr, Catherine Nock, Joseph Baumert, Steve Taylor, Carla Mastrorilli, Salvatore Tripodi, Carlo Caffarelli, Serena Perna, Andrea Di Rienzo Businco, Ifigenia Sfika, Arianna Dondi, Annamaria Bianchi, Carlotta Povesi Dascola, Giampaolo Ricci, Francesca Cipriani, Nunzia Maiello, Michele Miraglia del Giudice, Tullio Frediani, Simone Frediani, Francesco Macrì, Chiara Pistoletti, Iride Dello Iacono, Maria Francesca Patria, Elena Varin, Diego Peroni, Pasquale Comberiati, Loredana Chini, Viviana Moschese, Sandra Lucarelli, Roberto Bernardini, Giuseppe Pingitore, Umberto Pelosi, Roberta Olcese, Matteo Moretti, Anastasia Cirisano, Diego Faggian, Alessandro Travaglini, Mario Plebani, Maria Carmen Verga, Mauro Calvani, Paolo Giordani, Paolo Maria Matricardi, Noe Ontiveros, Francisco Cabrera-Chavez, Julie Galand, Etienne Beaudouin, The Anaphylaxis Working Group of the French Allergology SocietyThe Anaphylaxis Working Group of the French Allergology Society, Florence Pineau, Shinobu Sakai, Kayoko Matsunaga, Reiko Teshima, Colette Larré, Sandra Denery, Sebastian Tschirner, Valérie Trendelenburg, Gabriele Schulz, Bodo Niggemann, Kirsten Beyer, Youcef Bouferkas, Younes Belabbas, Djamel Saidi, Omar Kheroua, Kamel Eddine El Mecherfi, Malika Guendouz, Abir Haddi, Hanane Kaddouri, Luis Amaral, Ana Pereira, Susana Rodrigues, Mareen Datema, Laurian Jongejan, Michael Clausen, Andre Knulst, Nikolaos Papadopoulos, Marek Kowalski, Frédéric de Blay, Aeilko Zwinderman, Karin Hoffman-Sommergruber, Barbara Ballmer-Weber, Montserrat Fernandez-Rivas, Shan Deng, Jia Yin, Charlotte Eisenmann, Maria Nassiri, Rabea Reinert, Johanna P. M. van der Valk, Roy Gerth van Wijk, Yvonne Vergouwe, Ewout W. Steyerberg, Marit Reitsma, Harry J. Wichers, Huub F. J. Savelkoul, Berber Vlieg-Boerstra, Anthony E. J. Dubois, Fabrícia Carolino, Ana Rodolfo, Josefina Cernadas, Dasha Roa-Medellín, Ana Rodriguez-Fernandez, Joaquín Navarro, Vicente Albendiz, María Luisa Baeza, Sonsoles Intente-Herrero, Andrea Mikkelsen, Kirsten Mehlig, Lauren Lissner, Linda Verrill, Stefano Luccioli, Jolanda van Bilsen, Frieke Kuper, André Wolterbeek, Tanja Rouhani Rankouhi, Lars Verschuren, Hilde Cnossen, Prescilla Jeurink, Johan Garssen, Léon Knippels, Jossie Garthoff, Geert Houben, Winfried Leeman, M. Eleonore Pettersson, Afke M. M. Schins, Gerard H. Koppelman, Boudewjin J. Kollen, Svitlana Zubchenko, Sarah Kuntz, Pablo Mérida, Montserrat Álvaro, Monica Piquer, Carmen Riggioni, Juan Heber Castellanos, Rosa Jimenez, Melanie Cap, Elodie Drumez, Stéphanie Lejeune, Caroline Thumerelle, Clémence Mordacq, Véronique Nève, Sonia Ricò, Margherita Varini, Rita Nocerino, Linda Cosenza, Antonio Amoroso, Margherita Di Costanzo, Carmen Di Scala, Giorgio Bedogni, Roberto Berni Canani, Paul J. Turner, Paloma Poza-Guedes, Ruperto González-Pérez, Inmaculada Sánchez-Machín, Victor Matheu-Delgado, Erik Wambre, Anne-Sofie Ballegaard, Charlotte Madsen, Juliane Gregersen, Katrine Lindholm Bøgh, Philippe Aubert, Michel Neunlist, Antoine Magnan, Daniel Lozano-Ojalvo, Alba Pablos-Tanarro, Leticia Pérez-Rodríguez, Elena Molina, Rosina López-Fandiño, Akila Rekima, Patricia Macchiaverni, Mathilde Turfkruyer, Sebastien Holvoet, Lénaïck Dupuis, Nour Baiz, Isabella Annesi-Maesano, Annick Mercenier, Sophie Nutten, Valérie Verhasselt, Ines Mrakovcic-Sutic, Srdan Banac, Ivana Sutic, Zdenka Baricev-Novakovic, Ingrid Sutic, Valentino Pavisic, Rosa Muñoz-Cano, Teodoríkez Jiménez-Rodríguez, Daniel Corbacho, Jordi Roca-Ferrer, Joan Bartra, Aleksandar Bulog, Vladimir Micovic, Lidia Markiewicz, Agata Szymkiewicz, Anna Szyc, Barbara Wróblewska, Bryan M. Harvey, Lucien F. Harthoorn, A. Wesley Burks, Georgios Rentzos, Anna-Lena Bramstång Björk, Ulf Bengtsson, Colin Barber, Chrystyna Kalicinsky, Christine Breynaert, Lieve Coorevits, Cornelia Jansen, Erna Van Hoeyveld, Kristin Verbeke, Anne-Marie Kochuyt, Rik Schrijvers, Diana Deleanu, Adriana Muntean, Maria Konstantakopoulou, Maria Pasioti, Anastasia Papadopoulou, Anna Iliopoulou, Nikolaos Mikos, Evangelia Kompoti, Eunice Dias de Castro, Borja Bartalomé, Kok Loong Ue, Elizabeth Griffiths, Stephen Till, Kate Grimshaw, Graham Roberts, Anna Selby, Indre Butiene, Jose Ignacio Larco, Ruta Dubakiene, Ana Fiandor, Alessandro Fiocchi, Nikos Papadopoulos, Sigurveig Sigurdardottir, Aline Sprikkelman, Anne-Fleur Schoemaker, Paraskevi Xepapadaki, Thomas Keil, Zizi Cojocariu, Beatriz Secades Barbado, Vasti Iancu, Esozia Arroabarren, Marta Goñi Esarte, Miren Arteaga, Mayra Coutinho Andrade, Denise Borges, Jorge Kalil, Pedro Giavina Bianchi, Rosana Camara Agondi, Rinkesh Kumar Gupta, Akanksha Sharma, Kriti Gupta, Mukul Das, Premendra Dwivedi, Rusudan Karseladze, Liana Jorjoliani, Lali Saginadze, Mariam Tskhakaia, Katia Basello, Gabriele Piuri, Attilio Francesco Speciani, Michela Carola Speciani, Carla Camerotto, Francesco Zinno, Olga Pakholchuk, Svitlana Nedelska, Stefano Pattini, Maria Teresa Costantino, Silvia Peveri, Danilo Villalta, Eleonora Savi, Andrea Costanzi, Vera A. Revyakina, Marina A. Kiseleva, Elena D. Kuvshinova, Inna A. Larkova, Anton A. Shekhetov, Diana Silva, André Moreira, José Plácido, Hanneke van der Kleij, Esther van Twuijver, Robbert Sutorius, Pieter-Jan de Kam, Jenny van Odijk, Helen Lindqvist, Elin Lustig, Amyra Ali Azamar Jácome, Karla Leversia Borjas Aguilar, Miguel García Domínguez, David Alejandro Mendoza Hernández, Cristiano Caruso, Cono Casale, Gian Lodovico Rapaccini, Antonino Romano, Italo De Vitis, Renata R. Cocco, Carolina Aranda, Marcia C. Mallozi, Jackeline F. Motta, Lilian Moraes, Antonio Pastorino, Nelson Rosario, Ekaterini Goudouris, Arnaldo Porto, Neusa F. Wandalsen, Emanuel Sarinho, Flavio Sano, Dirceu Solé, Constantinos Pitsios, Maria Petrodimopoulou, Ekaterini Papadopoulou, Maria Passioti, Meropi Kontogianni, Nino Adamia, Ekaterina Khaleva, Ana Prieto del Prado, George Du Toit, Edyta Krzych, Urszula Samolinska-Zawisza, Konrad Furmanczyk, Aneta Tomaszewska, Filip Raciborski, Agnieszka Lipiec, Piotr Samel-Kowalik, Artur Walkiewicz, Jacek Borowicz, Boleslaw Samolinski, Aimee Lou Nano, Marysia Recto, Maria Luisa Somoza, Natalia Blanca López, Diana Pérez Alzate, Francisco Javier Ruano, Maria Isabel Garcimartín, Elisa Haroun, Maria Vázquez de la Torre, Antonia Rojas, Montserrat López Onieva, Gabriela Canto, Alexandra Rodrigues, Andreia Forno, António Jorge Cabral, Rute Gonçalves, Ilya Vorozhko, Tatyana Sentsova, Olga Chernyak, Svetlana Denisova, Lidia Ilènko, Valery Muhortnich, Caroline Zimmermann, Alexander Rohrbach, Faisal R. Bakhsh, Kollen Boudewijn, Anne-Marie Oomkes-Pilon, Dorien Van Ginkle, Mira Šilar, Anja Jeverica, Tina Vesel, Tadej Avčin, Peter Korošec, Johanna van der Valk, Irene Berends, Nicolette Arends, Maurits van Maaren, Harry Wichers, Joyce Emons, Anthony Dubois, Nicolette de Jong, Oksana Matsyura, Lesya Besh, Chung-Hsiung Huang, Tong-Rong Jan, Gary Stiefel, Jean Tratt, Kerrie Kirk, Fabricia Carolino, Stefania Arasi, Lucia Caminiti, Giuseppe Crisafulli, Chiara Fiamingo, Jlenia Fresta, Giovanni Pajno, Ben Remington, Astrid Kruizinga, W. Marty Blom, Joost Westerhout, Sabina Bijlsma, Joe Baumert, Mark Blankestijn, Henny Otten, Rob Klemans, Anouska D. Michelsen-Huisman, Harmieke van Os-Medendorp, Astrid G. Kruizinga, Astrid Versluis, Gert van Duijn, H. Mary-Lene de Zeeuw-Brouwer, Jacqueline J. M. Castenmiller, Hub P. J. M. Noteborn, Geert F. Houben, Kristian Bravin, David Luyt, Bushra Javed, Phil Couch, Christopher Munro, Phil Padfield, Matt Sperrin, Aideen Byrne, Lizalet Oosthuizen, Carina Kelleher, Fiona Ward, Niamh Brosnan, Graham King, Eva Corbet, Josué Alejandro Huertas Guzmán, Montserrat Bosque García, Oscar Asensio, Laura Valdesoiro Navarrete, Helena Larramona, Xavier Domingo Miró, Katarzyna Pyrz, Moira Austin, Yanne Boloh, Philip Couch, Deirdre Galloway, Pilar Hernandez, Jonathan O’B. Hourihane, Fiona Kenna, Barbara Majkowska-Wojciechowska, Lynne Regent, Marina Themisb, Sabine Schnadt, Aida Semic-Jusufagic, Audrey Dunn Galvin, Tiina Kauppila, Mikael Kuitunen, Nikolaos A. Kitsioulis, Nikolaos Douladiris, Sofia Kostoudi, Ioanna Manolaraki, Dimitris Mitsias, Emmanouil Manousakis, Nikolaos G. Papadopoulos, Rebecca Knibb, Jennifer Hammond, Richard Cooke, Jaakko Yrjänä, Anna-Maija Hanni, Päivi Vähäsarja, Oona Mustonen, Teija Dunder, Petri Kulmala, Eva Lasa, Carmen D’Amelio, Sara Martínez, Alejandro Joral, Gabriel Gastaminza, Maria Jose Goikoetxea, David C. A. Candy, Marleen T. J. Van Ampting, Manon M. Oude Nijhuis, Assad M. Butt, Diego G. Peroni, Adam T. Fox, Jan Knol, Louise J. Michaelis, Ines Padua, Patricia Padrao, Pedro Moreira, Renata Barros, Hanan Sharif, Manzoor Ahmed, Nehad Gomaa, Joris Mens, Koen Smit, Frans Timmermans, Tomaž Poredoš, Anja Koren Jeverica, Marjeta Sedmak, Evgen Benedik, Meta Accetto, Mirjana Zupančič, Glauce Yonamine, Gustavo Soldateli, Bruna Aquilante, Antonio Carlos Pastorino, Cleonir Lui de Moraes Beck, Andrea Keiko Gushken, Mayra de Barros Dorna, Cristiane Nunes dos Santos, Ana Paula Moschione Castro, Abdulhadi Al-Qahtani, Rand Arnaout, Agha Rehan Khaliq, Rashid Amin, Farrukh Sheikh, Jorge Alvarez, Marta Anda, Miriam Palacios, Montserrat De Prada, Carmen Ponce, Bianca Balbino, Riccardo Sibilano, Thomas Marichal, Nicolas Gaudenzio, Hajime Karasuyama, Pierre Bruhns, Mindy Tsai, Laurent L. Reber, Stephen J. Galli, Ana Reis Ferreira, Josefina R. Cernadas, Aida del Campo García, Sara Pereiro Fernández, Nerea Sarmiento Carrera, Fernando Bandrés Sánchez-Cruz, José Ramón Fernández Lorenzo, Stephanie Claus, Claudia Pföhler, Franziska Ruëff, Regina Treudler, Mercedes Escarrer Jaume, Agustin Madroñero, Maria Teresa Guerra Perez, Juan Carlos Julia, Charlotte Hands Plovdiv, Lee Gethings, Jim Langridge, Karine Adel-Patient, Hervé Bernard, Ivona Barcievic-Jones, Raditsa Sokolova, Rumyana Yankova, Mariya Ivanovska, Marianna Murdjeva, Tatyana Popova, Svetlan Dermendzhiev, Martin Karjalainen, Ulrike Lehnigk, Duncan Brown, Julie C. Locklear, Julie Locklear, Ioana Maris, Jonathan Hourihane, Cristina Ornelas, Joana Caiado, Manuel Branco Ferreira, Manuel Pereira-Barbosa, Yolanda Puente, Juan Carlos Daza, Francisco Javier Monteseirin, Natalia Ukleja-Sokolowska, Ewa Gawronska-Ukleja, Magdalena Zbikowska-Gotz, Zbigniew Bartuzi, Lukasz Sokolowski, Aine Adams, Bernard Mahon, Karen English, Nelly Gourdon-Dubois, Laetitia Sellam, Bruno Pereira, Elodie Michaud, Khaled Messaoudi, Bertrand Evrard, Jean-Luc Fauquert, Francisca Palomares, Gador Gomez, Maria Jose Rodriguez, Luisa Galindo, Ana Molina, Lorella Paparo, Maurizio Mennini, Rosita Aitoro, Adam Wawrzeńczyk, Michał Przybyszewski, Anna Wawrzeńczyk, Hulya Ercan Sarıcoban, Meltem Ugras, Zerrin Yalvac, Bertine M. J. Flokstra-de Blok, J. L. van der Velde, Andrea Vereda, Clara Ippolito, Amaranta Traversa, Daniela Adriano, Daniela Manila Bianchi, Silvia Gallina, Lucia Decastelli, Melina Makatsori, Anne Miles, Sonja Posega Devetak, Iztok Devetak, Soraya Ainad Tabet, Jeanette Fisker Trandbohus, Pernille Winther, Hans-Jørgen Malling, Kirsten Skamstrup Hansen, Lene Heise Garvey, Chia-Chi Wang, Yin-Hua Cheng, Chun-Wei Tung, Mariola Dietrich, Ingo Marenholz, Birgit Kalb, Sarah Grosche, Katharina Blümchen, Rupert Schlags, Mareike Price, Sylke Rietz, Jorge Esparza-Gordillo, Susanne Lau, Young-Ae Lee, Ali Almontasheri, Mohammad Al Bahkali, Sahar Elshorbagi, Abdullah Alfhaid, Mashary Altamimi, Eman Madbouly, Hassan Al-Dhekri, Rand K. Arnaout, Maria Basagaña, Sira Miquel, Borja Bartolomé, Bettina Brix, Stefanie Rohwer, Sandra Brandhoff, Alena Berger, Waltraud Suer, Alf Weimann, Cristina Bueno, Laura Martín-Pedraza, Sara Abián, Pablo San Segundo-Acosta, Juan Carlos López-Rodríguez, Rodrigo Barderas, Eva Batanero, Javier Cuesta-Herranz, María Teresa Villalba, Magna Correia, Filipe Benito-Garcia, Cristina Arêde, Susana Piedade, Mário Morais-Almeida, James Hindley, Ross Yarham, Anna Kuklinska-Pijanka, David Gillick, Karine Patient, Martin D. Chapman, Katrine L. Bøgh, Ana Miranda, Eugénia Matos, Anna Sokolova, Huan Rao, Ivona Baricevic-Jones, Frances Smith, Wentong Xue, Helga Magnusdottir, Anna G. Vidarsdottir, Sigrun Lund, Anders Blom Jensen, Bjorn R. Ludviksson, Reyna Simon, Robert Elfont, Sean Bennett, Robert Voyksner, Maria de Lurdes Torre, Songül Yürek, Margaretha A. Faber, Annick Bastiaensen, Evelyne Mangodt, Athina van Gasse, Ine Decuyper, Vito Sabato, Margo M. Hagendorens, Chris H. Bridts, Luc S. De Clerck, Didier Ebo, Susanne Schwarz, Mandy Ziegert, Saskia Albroscheit, Christian Schwager, Skadi Kull, Jochen Behrends, Niels Röckendorf, Frauke Schocker, Andreas Frey, Arne Homann, Wolf-Meinhard Becker, Uta Jappe, Nesrine Zaabat, Sylvia Osscini, Chantal Agabriel, Benoît Sterling, Ania Carsin, Valérie Liabeuf, Monica Maćków, Alina Zbróg, Monica Bronkowska, Justine Courtois, Romy Gadisseur, Catherine Bertholet, Pierre Lukas, Etienne Cavalier, Philippe Delahaut, Birgit Quinting, Margareta Brandt Gertmo, Ewa Ternesten Hasseus, Vladyslava Barzylovych, Júlio Oliveira, Luis F. Ensina, Carolina S. Aranda, Leire Dopazo, Rebeca Lopez, Raquel Perez, Laura Santos-Diez, Agurtzane Bilbao, Juan Miguel Garcia, Ignacio García Núñez, María Ángeles Algaba Mármol, María José Barasona Villarejo, José Antonio Bácter Martos, Marina Suárez Vergara, José María Ignacio García, Agata Michalska, Grzegorz Sergiejko, Robert Zacniewski, Ileana-Maria Ghiordanescu, Cristina Deaconu, Mihaela Popescu, Roxana Silvia Bumbacea, Alkerta Ibranji, Elida Nikolla, Gjustina Loloci, Nanna Juel-Berg, Lau Fabricius Larsen, Lars Kjaergaard Poulsen, João Marcelino, Ricardo Prata, Ana Célia Costa, Fátima Duarte, Marta Neto, Jennifer Santos, Luís Câmara Pestana, Daniel Sampaio, Paola Minale, Paola Dignetti, Donatella Bignardi, Irena Nedelea, Florin-Dan Popescu, Mariana Vieru, Florin-Adrian Secureanu, Carmen Saviana Ganea, Miguel Vieira, José Pedro Moreira Silva, Timothy Watts, Sophia Watts, Marta Lomikovska, Marina Peredelskaya, Natalia Nenasheva, Ivana Filipovic, Zorica Zivkovic, Djordje Filipovic, Jennette Higgs, Amena Warner, and Carla Jones
Subjects: Immunologic diseases. Allergy, RC581-607
Published: 2017
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28. An alternative path to oral tolerance

Author: Li, Carmen H., primary, Kabak, Ekaterina, additional, and Eiwegger, Thomas, additional
Published: 2023
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29. Does the Use of the “Proseek® Multiplex Inflammation I Panel” Demonstrate a Difference in Local and Systemic Immune Responses in Endometriosis Patients with or without Deep-Infiltrating Lesions?

Author: Perricos, Alexandra, primary, Husslein, Heinrich, additional, Kuessel, Lorenz, additional, Gstoettner, Manuela, additional, Weinhaeusel, Andreas, additional, Eiwegger, Thomas, additional, Beikircher, Gabriel, additional, and Wenzl, René, additional
Published: 2023
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30. Identification of motivators and barriers impacting successful food introduction or reintroduction after negative oral food challenges

Author: Ditlof, Christina M., primary, Hummel, Roxanne H., additional, Wong, Sam, additional, Li, Carmen H., additional, Alexanian-Farr, Mara, additional, Zahrebelny, Slavka O., additional, Hoang, Jennifer A., additional, Hung, Lisa, additional, Upton, Julia E.M., additional, Atkinson, Adelle R., additional, Asper, Maria, additional, Hummel, David, additional, and Eiwegger, Thomas, additional
Published: 2023
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31. Correction to: Protocol for a double-blind, randomized controlled trial on the dose-related efficacy of omalizumab in multi-food oral immunotherapy

Author: Alexandra Langlois, Marie-Hélène Lavergne, Hélène Leroux, Kerstin Killer, Pauline Azzano, Louis Paradis, Kathryn Samaan, Jonathan Lacombe-Barrios, Thomas Eiwegger, Julia Upton, Gordon Sussman, Thomas Poder, Benoît Mâsse, Anne Des Roches, and Philippe Bégin
Subjects: Immunologic diseases. Allergy, RC581-607
Abstract: An amendment to this paper has been published and can be accessed via the original article.
Published: 2020
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32. Introducing peanut early in life – Ready for the general population?

Author: Szépfalusi, Zsolt, primary and Eiwegger, Thomas, additional
Published: 2023
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33. Assessing Allergic Reactions to Cephalosporins in Children

Author: Sillcox, Carly, primary, O’Keefe, Andrew, additional, McCusker, Christine, additional, Gabrielli, Sofianne, additional, Abrams, Elissa, additional, Eiwegger, Thomas, additional, Atkinson, Adelle, additional, Kim, Vy, additional, Copaescu, Ana-Maria, additional, and Ben-Shoshan, Moshe, additional
Published: 2023
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34. How low can we go: preliminary efficacy of very low dose peanut oral immunotherapy

Author: Upton, Julia, primary, Lejteyni, Duncan, additional, Ke, Danbing, additional, Berenjy, Alireza, additional, Beaudette, Liane, additional, McCusker, Christine, additional, Yin, Xiaojun, additional, Li, Carmen, additional, Duan, Lucy, additional, Marzouk, Shireen, additional, Grunebaum, Eyal, additional, Eiwegger, Thomas, additional, and Ben-Shoshan, Moshe, additional
Published: 2023
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35. Precision cut intestinal slices, a novel model of acute food allergic reactions

Author: Hung, Lisa, Celik, Alper, Yin, Xiaojun, Yu, Kai, Berenjy, Alireza, Kothari, Akash, Obernolte, Helena, Upton, Julia E. M., Lindholm Bøgh, Katrine, Somers, Gino R., Siddiqui, Iram, Grealish, Martin, Quereshy, Fayez A., Sewald, Katherina, Chiu, Priscilla P. L., Eiwegger, Thomas, Hung, Lisa, Celik, Alper, Yin, Xiaojun, Yu, Kai, Berenjy, Alireza, Kothari, Akash, Obernolte, Helena, Upton, Julia E. M., Lindholm Bøgh, Katrine, Somers, Gino R., Siddiqui, Iram, Grealish, Martin, Quereshy, Fayez A., Sewald, Katherina, Chiu, Priscilla P. L., and Eiwegger, Thomas
Abstract: Background: Food allergy affects up to 10% of the pediatric population. Despite ongoing efforts, treatment options remain limited. Novel models of food allergy are needed to study response patterns downstream of IgE-crosslinking and evaluate drugs modifying acute events. Here, we report a novel human ex vivo model that displays acute, allergen-specific, IgE-mediated smooth muscle contractions using precision cut intestinal slices (PCIS). Methods: PCIS were generated using gut tissue samples from children who underwent clinically indicated surgery. Viability and metabolic activity were assessed from 0-24h. Distribution of relevant cell subsets was confirmed using single nucleus RNA sequencing. PCIS were passively sensitized using plasma from peanut allergic donors or peanut-sensitized non-allergic donors, and exposed to various stimuli including serotonin, histamine, FcɛRI-crosslinker and food allergens. Smooth muscle contractions and mediator release functioned as readouts. A novel program designed to measure contractions was developed to quantify responses. The ability to demonstrate the impact of antihistamines and immunomodulation from peanut oral immunotherapy (OIT) was assessed. Results: PCIS viability was maintained for 24h. Cellular distribution confirmed the presence of key cell subsets including mast cells. The video analysis tool reliably quantified responses to different stimulatory conditions. Smooth muscle contractions were allergen-specific and reflected the clinical phenotype of the plasma donor. Tryptase measurement confirmed IgE-dependent mast cell-derived mediator release. Antihistamines suppressed histamine-induced contraction and plasma from successful peanut OIT suppressed peanut-specific PCIS contraction. Conclusion: PCIS represent a novel human tissue-based model to study acute, IgE-mediated food allergy and pharmaceutical impacts on allergic responses in the gut.
Published: 2023

36. EAACI guidelines on the diagnosis of IgE-mediated food allergy

Author: CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Santos, Alexandra F, Riggioni, Carmen, Agache, Ioana, Akdis, Cezmi A, Akdis, Mubeccel, Alvarez-Perea, Alberto, Alvaro-Lozano, Montserrat, Ballmer-Weber, Barbara, Barni, Simona, Beyer, Kirsten, Bindslev-Jensen, Carsten, Brough, Helen A, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano, Dunn-Galvin, Audrey, Eberlein, Bernadette, Ebisawa, Motohiro, Eigenmann, Philippe, Eiwegger, Thomas, Feeney, Mary, Fernandez-Rivas, Montserrat, Fisher, Helen R, Fleischer, David M, Giovannini, Mattia, Gray, Claudia, Hoffmann-Sommergruber, Karin, Halken, Susanne, Hourihane, Jonathan O'B, Jones, Christina J, Jutel, Marek, Knol, Edward, Konstantinou, George N, Lack, Gideon, Lau, Susanne, Marques Mejias, Andreina, Marchisotto, Mary Jane, Meyer, Rosan, Mortz, Charlotte G, Moya, Beatriz, Muraro, Antonella, Nilsson, Caroline, Lopes de Oliveira, Lucila Camargo, O'Mahony, Liam, Papadopoulos, Nikolaos G, Perrett, Kirsten, Peters, Rachel L, Podesta, Marcia, Poulsen, Lars K, Roberts, Graham, Sampson, Hugh A, Schwarze, Jürgen, Smith, Peter, Tham, Elizabeth Huiwen, Untersmayr, Eva, Van Ree, Ronald, Venter, Carina, Vickery, Brian P, Vlieg-Boerstra, Berber, Werfel, Thomas, Worm, Margitta, Du Toit, George, Skypala, Isabel, CTI Research, MS Dermatologie/Allergologie, Infection & Immunity, Santos, Alexandra F, Riggioni, Carmen, Agache, Ioana, Akdis, Cezmi A, Akdis, Mubeccel, Alvarez-Perea, Alberto, Alvaro-Lozano, Montserrat, Ballmer-Weber, Barbara, Barni, Simona, Beyer, Kirsten, Bindslev-Jensen, Carsten, Brough, Helen A, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano, Dunn-Galvin, Audrey, Eberlein, Bernadette, Ebisawa, Motohiro, Eigenmann, Philippe, Eiwegger, Thomas, Feeney, Mary, Fernandez-Rivas, Montserrat, Fisher, Helen R, Fleischer, David M, Giovannini, Mattia, Gray, Claudia, Hoffmann-Sommergruber, Karin, Halken, Susanne, Hourihane, Jonathan O'B, Jones, Christina J, Jutel, Marek, Knol, Edward, Konstantinou, George N, Lack, Gideon, Lau, Susanne, Marques Mejias, Andreina, Marchisotto, Mary Jane, Meyer, Rosan, Mortz, Charlotte G, Moya, Beatriz, Muraro, Antonella, Nilsson, Caroline, Lopes de Oliveira, Lucila Camargo, O'Mahony, Liam, Papadopoulos, Nikolaos G, Perrett, Kirsten, Peters, Rachel L, Podesta, Marcia, Poulsen, Lars K, Roberts, Graham, Sampson, Hugh A, Schwarze, Jürgen, Smith, Peter, Tham, Elizabeth Huiwen, Untersmayr, Eva, Van Ree, Ronald, Venter, Carina, Vickery, Brian P, Vlieg-Boerstra, Berber, Werfel, Thomas, Worm, Margitta, Du Toit, George, and Skypala, Isabel
Published: 2023

37. Pathogenesis, immunology, and immune-targeted management of the multisystem inflammatory syndrome in children (MIS-C) or pediatric inflammatory multisystem syndrome (PIMS): EAACI Position Paper

Author: European Commission, Swiss National Science Foundation, European Academy of Allergy and Clinical Immunology, Innovation Fund Denmark, Instituto de Salud Carlos III, Feleszko, Wojciech, Okarska-Napierała, Magdalena, Buddingh, Emilie Pauline, Bloomfield, Marketa, Sediva, Anna, Bautista-Rodriguez, Carles, Brough, Helen A., Eigenmann, Philippe A., Eiwegger, Thomas, Eljaszewicz, Andrzej, Eyerich, Stefanie, Gomez-Casado, Cristina, Fraisse, Alain, Janda, Jozef, Jiménez Saiz, Rodrigo, Kallinich, Tilmann, Krohn, Inge Kortekaas, Mortz, Charlotte G., Riggioni, Carmen, Sastre, Joaquin, Sokolowska, Milena, Strzelczyk, Ziemowit, Untersmayr, Eva, Tramper-Stranders, Gerdien, European Commission, Swiss National Science Foundation, European Academy of Allergy and Clinical Immunology, Innovation Fund Denmark, Instituto de Salud Carlos III, Feleszko, Wojciech, Okarska-Napierała, Magdalena, Buddingh, Emilie Pauline, Bloomfield, Marketa, Sediva, Anna, Bautista-Rodriguez, Carles, Brough, Helen A., Eigenmann, Philippe A., Eiwegger, Thomas, Eljaszewicz, Andrzej, Eyerich, Stefanie, Gomez-Casado, Cristina, Fraisse, Alain, Janda, Jozef, Jiménez Saiz, Rodrigo, Kallinich, Tilmann, Krohn, Inge Kortekaas, Mortz, Charlotte G., Riggioni, Carmen, Sastre, Joaquin, Sokolowska, Milena, Strzelczyk, Ziemowit, Untersmayr, Eva, and Tramper-Stranders, Gerdien
Abstract: Multisystem inflammatory syndrome in children (MIS-C) is a rare, but severe complication of coronavirus disease 2019 (COVID-19). It develops approximately 4 weeks after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and involves hyperinflammation with multisystem injury, commonly progressing to shock. The exact pathomechanism of MIS-C is not known, but immunological dysregulation leading to cytokine storm plays a central role. In response to the emergence of MIS-C, the European Academy of Allergy and Clinical Immunology (EAACI) established a task force (TF) within the Immunology Section in May 2021. With the use of an online Delphi process, TF formulated clinical statements regarding immunological background of MIS-C, diagnosis, treatment, follow-up, and the role of COVID-19 vaccinations. MIS-C case definition is broad, and diagnosis is made based on clinical presentation. The immunological mechanism leading to MIS-C is unclear and depends on activating multiple pathways leading to hyperinflammation. Current management of MIS-C relies on supportive care in combination with immunosuppressive and/or immunomodulatory agents. The most frequently used agents are systemic steroids and intravenous immunoglobulin. Despite good overall short-term outcome, MIS-C patients should be followed-up at regular intervals after discharge, focusing on cardiac disease, organ damage, and inflammatory activity. COVID-19 vaccination is a safe and effective measure to prevent MIS-C. In anticipation of further research, we propose a convenient and clinically practical algorithm for managing MIS-C developed by the Immunology Section of the EAACI.
Published: 2023

38. EAACI guidelines on the diagnosis of IgE‐mediated food allergy

Author: Santos, Alexandra F; https://orcid.org/0000-0002-7805-1436, Riggioni, Carmen; https://orcid.org/0000-0002-8745-0228, Agache, Ioana; https://orcid.org/0000-0001-7994-364X, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, Akdis, Mubeccel; https://orcid.org/0000-0003-0554-9943, Alvarez‐Perea, Alberto; https://orcid.org/0000-0001-7417-7309, Alvaro‐Lozano, Montserrat; https://orcid.org/0000-0002-5528-8043, Ballmer‐Weber, Barbara; https://orcid.org/0000-0002-4136-5036, Barni, Simona, Beyer, Kirsten, Bindslev‐Jensen, Carsten; https://orcid.org/0000-0002-8940-038X, Brough, Helen A; https://orcid.org/0000-0001-7203-0813, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano; https://orcid.org/0000-0002-4517-1749, Dunn‐Galvin, Audrey; https://orcid.org/0000-0002-1540-3959, Eberlein, Bernadette; https://orcid.org/0000-0003-4509-6491, Ebisawa, Motohiro; https://orcid.org/0000-0003-4117-558X, Eigenmann, Philippe, Eiwegger, Thomas; https://orcid.org/0000-0002-2914-7829, Feeney, Mary; https://orcid.org/0000-0003-0594-7052, Fernandez‐Rivas, Montserrat; https://orcid.org/0000-0003-1748-2328, Fisher, Helen R; https://orcid.org/0000-0002-5958-4587, Fleischer, David M, Giovannini, Mattia; https://orcid.org/0000-0001-9568-6882, Gray, Claudia, Hoffmann‐Sommergruber, Karin; https://orcid.org/0000-0002-8830-058X, Halken, Susanne; https://orcid.org/0000-0003-0161-8278, Hourihane, Jonathan O’B, Jones, Christina J; https://orcid.org/0000-0003-3672-6631, et al, Santos, Alexandra F; https://orcid.org/0000-0002-7805-1436, Riggioni, Carmen; https://orcid.org/0000-0002-8745-0228, Agache, Ioana; https://orcid.org/0000-0001-7994-364X, Akdis, Cezmi A; https://orcid.org/0000-0001-8020-019X, Akdis, Mubeccel; https://orcid.org/0000-0003-0554-9943, Alvarez‐Perea, Alberto; https://orcid.org/0000-0001-7417-7309, Alvaro‐Lozano, Montserrat; https://orcid.org/0000-0002-5528-8043, Ballmer‐Weber, Barbara; https://orcid.org/0000-0002-4136-5036, Barni, Simona, Beyer, Kirsten, Bindslev‐Jensen, Carsten; https://orcid.org/0000-0002-8940-038X, Brough, Helen A; https://orcid.org/0000-0001-7203-0813, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano; https://orcid.org/0000-0002-4517-1749, Dunn‐Galvin, Audrey; https://orcid.org/0000-0002-1540-3959, Eberlein, Bernadette; https://orcid.org/0000-0003-4509-6491, Ebisawa, Motohiro; https://orcid.org/0000-0003-4117-558X, Eigenmann, Philippe, Eiwegger, Thomas; https://orcid.org/0000-0002-2914-7829, Feeney, Mary; https://orcid.org/0000-0003-0594-7052, Fernandez‐Rivas, Montserrat; https://orcid.org/0000-0003-1748-2328, Fisher, Helen R; https://orcid.org/0000-0002-5958-4587, Fleischer, David M, Giovannini, Mattia; https://orcid.org/0000-0001-9568-6882, Gray, Claudia, Hoffmann‐Sommergruber, Karin; https://orcid.org/0000-0002-8830-058X, Halken, Susanne; https://orcid.org/0000-0003-0161-8278, Hourihane, Jonathan O’B, Jones, Christina J; https://orcid.org/0000-0003-3672-6631, and et al
Abstract: This European Academy of Allergy and Clinical Immunology guideline provides recommendations for diagnosing IgE‐mediated food allergy and was developed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Food allergy diagnosis starts with an allergy‐focused clinical history followed by tests to determine IgE sensitization, such as serum allergen‐specific IgE (sIgE) and skin prick test (SPT), and the basophil activation test (BAT), if available. Evidence for IgE sensitization should be sought for any suspected foods. The diagnosis of allergy to some foods, such as peanut and cashew nut, is well supported by SPT and serum sIgE, whereas there are less data and the performance of these tests is poorer for other foods, such as wheat and soya. The measurement of sIgE to allergen components such as Ara h 2 from peanut, Cor a 14 from hazelnut and Ana o 3 from cashew can be useful to further support the diagnosis, especially in pollen‐sensitized individuals. BAT to peanut and sesame can be used additionally. The reference standard for food allergy diagnosis is the oral food challenge (OFC). OFC should be performed in equivocal cases. For practical reasons, open challenges are suitable in most cases. Reassessment of food allergic children with allergy tests and/or OFCs periodically over time will enable reintroduction of food into the diet in the case of spontaneous acquisition of oral tolerance.
Published: 2023

39. EAACI guidelines on the diagnosis of IgE-mediated food allergy

Author: Santos, Alexandra F, Riggioni, Carmen, Agache, Ioana, Akdis, Cezmi A, Akdis, Mubeccel, Alvarez-Perea, Alberto, Alvaro-Lozano, Montserrat, Ballmer-Weber, Barbara, Barni, Simona, Beyer, Kirsten, Bindslev-Jensen, Carsten, Brough, Helen A, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano, Dunn-Galvin, Audrey, Eberlein, Bernadette, Ebisawa, Motohiro, Eigenmann, Philippe, Eiwegger, Thomas, Feeney, Mary, Fernandez-Rivas, Montserrat, Fisher, Helen R, Fleischer, David M, Giovannini, Mattia, Gray, Claudia, Hoffmann-Sommergruber, Karin, Halken, Susanne, Hourihane, Jonathan O'B, Jones, Christina J, Jutel, Marek, Knol, Edward, Konstantinou, George N, Lack, Gideon, Lau, Susanne, Marques Mejias, Andreina, Marchisotto, Mary Jane, Meyer, Rosan, Mortz, Charlotte G, Moya, Beatriz, Muraro, Antonella, Nilsson, Caroline, Lopes de Oliveira, Lucila Camargo, O'Mahony, Liam, Papadopoulos, Nikolaos G, Perrett, Kirsten, Peters, Rachel L, Podesta, Marcia, Poulsen, Lars K, Roberts, Graham, Sampson, Hugh A, Schwarze, Jürgen, Smith, Peter, Tham, Elizabeth Huiwen, Untersmayr, Eva, Van Ree, Ronald, Venter, Carina, Vickery, Brian P, Vlieg-Boerstra, Berber, Werfel, Thomas, Worm, Margitta, Du Toit, George, Skypala, Isabel, Santos, Alexandra F, Riggioni, Carmen, Agache, Ioana, Akdis, Cezmi A, Akdis, Mubeccel, Alvarez-Perea, Alberto, Alvaro-Lozano, Montserrat, Ballmer-Weber, Barbara, Barni, Simona, Beyer, Kirsten, Bindslev-Jensen, Carsten, Brough, Helen A, Buyuktiryaki, Betul, Chu, Derek, Del Giacco, Stefano, Dunn-Galvin, Audrey, Eberlein, Bernadette, Ebisawa, Motohiro, Eigenmann, Philippe, Eiwegger, Thomas, Feeney, Mary, Fernandez-Rivas, Montserrat, Fisher, Helen R, Fleischer, David M, Giovannini, Mattia, Gray, Claudia, Hoffmann-Sommergruber, Karin, Halken, Susanne, Hourihane, Jonathan O'B, Jones, Christina J, Jutel, Marek, Knol, Edward, Konstantinou, George N, Lack, Gideon, Lau, Susanne, Marques Mejias, Andreina, Marchisotto, Mary Jane, Meyer, Rosan, Mortz, Charlotte G, Moya, Beatriz, Muraro, Antonella, Nilsson, Caroline, Lopes de Oliveira, Lucila Camargo, O'Mahony, Liam, Papadopoulos, Nikolaos G, Perrett, Kirsten, Peters, Rachel L, Podesta, Marcia, Poulsen, Lars K, Roberts, Graham, Sampson, Hugh A, Schwarze, Jürgen, Smith, Peter, Tham, Elizabeth Huiwen, Untersmayr, Eva, Van Ree, Ronald, Venter, Carina, Vickery, Brian P, Vlieg-Boerstra, Berber, Werfel, Thomas, Worm, Margitta, Du Toit, George, and Skypala, Isabel
Abstract: This European Academy of Allergy and Clinical Immunology guideline provides recommendations for diagnosing IgE-mediated food allergy and was developed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Food allergy diagnosis starts with an allergy-focused clinical history followed by tests to determine IgE sensitization, such as serum allergen-specific IgE (sIgE) and skin prick test (SPT), and the basophil activation test (BAT), if available. Evidence for IgE sensitization should be sought for any suspected foods. The diagnosis of allergy to some foods, such as peanut and cashew nut, is well supported by SPT and serum sIgE, whereas there are less data and the performance of these tests is poorer for other foods, such as wheat and soya. The measurement of sIgE to allergen components such as Ara h 2 from peanut, Cor a 14 from hazelnut and Ana o 3 from cashew can be useful to further support the diagnosis, especially in pollen-sensitized individuals. BAT to peanut and sesame can be used additionally. The reference standard for food allergy diagnosis is the oral food challenge (OFC). OFC should be performed in equivocal cases. For practical reasons, open challenges are suitable in most cases. Reassessment of food allergic children with allergy tests and/or OFCs periodically over time will enable reintroduction of food into the diet in the case of spontaneous acquisition of oral tolerance.
Published: 2023

40. SLAP Is a Negative Regulator of FcεRI Receptor-Mediated Signaling and Allergic Response

Author: Namit Sharma, Marta Ponce, Savar Kaul, Zhongda Pan, Donna M. Berry, Thomas Eiwegger, and Catherine J. McGlade
Subjects: IgE receptor, mast cell, basophil, signaling, Cbl-b, SLAP, Immunologic diseases. Allergy, RC581-607
Abstract: Binding of antigen to IgE-high affinity FcεRI complexes on mast cells and basophils results in the release of preformed mediators such as histamine and de novo synthesis of cytokines causing allergic reactions. Src-like adapter protein (SLAP) functions co-operatively with c-Cbl to negatively regulate signaling downstream of the T cell receptor, B cell receptor, and receptor tyrosine kinases (RTK). Here, we investigated the role of SLAP in FcεRI-mediated mast cell signaling, using bone marrow derived mast cells (BMMCs) from SLAP knock out (SLAP KO) mice. Mature SLAP-KO BMMCs displayed significantly enhanced antigen induced degranulation and synthesis of IL-6, TNFα, and MCP-1 compared to wild type (WT) BMMCs. In addition, SLAP KO mice displayed an enhanced passive cutaneous anaphylaxis response. In agreement with a negative regulatory role, SLAP KO BMMCs showed enhanced FcεRI-mediated signaling to downstream effector kinases, Syk, Erk, and Akt. Recombinant GST-SLAP protein binds to the FcεRIβ chain and to the Cbl-b in mast cell lysates, suggesting a role in FcεRI down regulation. In addition, the ubiquitination of FcεRIγ chain and antigen mediated down regulation of FcεRI is impaired in SLAP KO BMMCs compared to the wild type. In line with these findings, stimulation of peripheral blood human basophils with FcεRIα antibody, or a clinically relevant allergen, resulted in increased SLAP expression. Together, these results indicate that SLAP is a dynamic regulator of IgE-FcεRI signaling, limiting allergic responses.
Published: 2019
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41. Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases

Author: Akdis, Mübeccel, Aab, Alar, Altunbulakli, Can, Azkur, Kursat, Costa, Rita A., Crameri, Reto, Duan, Su, Eiwegger, Thomas, Eljaszewicz, Andrzej, Ferstl, Ruth, Frei, Remo, Garbani, Mattia, Globinska, Anna, Hess, Lena, Huitema, Carly, Kubo, Terufumi, Komlosi, Zsolt, Konieczna, Patricia, Kovacs, Nora, Kucuksezer, Umut C., Meyer, Norbert, Morita, Hideaki, Olzhausen, Judith, O'Mahony, Liam, Pezer, Marija, Prati, Moira, Rebane, Ana, Rhyner, Claudio, Rinaldi, Arturo, Sokolowska, Milena, Stanic, Barbara, Sugita, Kazunari, Treis, Angela, van de Veen, Willem, Wanke, Kerstin, Wawrzyniak, Marcin, Wawrzyniak, Paulina, Wirz, Oliver F., Zakzuk, Josefina Sierra, and Akdis, Cezmi A.
Published: 2016
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42. Identification of motivators and barriers impacting successful food introduction or reintroduction after negative oral food challenges

Author: Christina M. Ditlof, Roxanne H. Hummel, Sam Wong, Carmen H. Li, Mara Alexanian-Farr, Slavka O. Zahrebelny, Jennifer A. Hoang, Lisa Hung, Julia E.M. Upton, Adelle R. Atkinson, Maria Asper, David Hummel, and Thomas Eiwegger
Subjects: Immunology and Allergy
Published: 2023

43. IgE Testing

Author: Eiwegger, Thomas, Szépfalusi, Zsolt, Mackay, Ian R., editor, Rose, Noel R., editor, Ledford, Dennis K., editor, and Lockey, Richard F., editor
Published: 2014
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44. Genetic Regulation of IgE

Author: Szépfalusi, Zsolt, Eiwegger, Thomas, Mackay, Ian R., editor, Rose, Noel R., editor, Ledford, Dennis K., editor, and Lockey, Richard F., editor
Published: 2014
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45. Hyper-IgE Syndrome

Author: Eiwegger, Thomas, Szépfalusi, Zsolt, Mackay, Ian R., editor, Rose, Noel R., editor, Ledford, Dennis K., editor, and Lockey, Richard F., editor
Published: 2014
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46. Role of IgE in Disease

Author: Szépfalusi, Zsolt, Eiwegger, Thomas, Mackay, Ian R., editor, Rose, Noel R., editor, Ledford, Dennis K., editor, and Lockey, Richard F., editor
Published: 2014
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47. 6th International Symposium on Molecular Allergology (ISMA)

Author: Christiane Hilger, Kyra Swiontek, Jörg Fischer, François Hentges, Christiane Lehners, Martine Morisset, Bernadette Eberlein, Tilo Biedermann, Markus Ollert, Sabrina Wildner, Teresa Stemeseder, Regina Freier, Peter Briza, Roland Lang, Eva Batanero, Mayte Villalba, Jonas Lidholm, Thomas Hawranek, Fatima Ferreira, Hans Brandstetter, Gabriele Gadermaier, Philippe Moingeon, Rachel Groeme, Julien Bouley, Véronique Bordas, Maxime Le Mignon, Laetitia Bussières, Aurélie Lautrette, Laurent Mascarell, Vincent Lombardi, Véronique Baron-Bodo, Henri Chabre, Thierry Batard, Emmanuel Nony, Karine Marafigo De Amicis, Alexandra Sayuri Watanabe, Daniele Danella Figo, José Roberto Aparecido Dos Santos-Pinto, Mario Sergio Palma, Fabio Fernandes Morato Castro, Jorge Kalil, Therese Wohlschlager, Fatima Ferreira-Briza, Keity Souza Santos, Margaretha Faber, Athina Van Gasse, Vito Sabato, Margo M. Hagendorens, Chris H. Bridts, Luc S. De Clerck, Araceli Diaz Perales, Didier Ebo, Petra Zavadakova, Aurélie Buchwalder, Fabien Rebeaud, Iwan Märki, Barbara Gepp, Nina Lengger, Christian Möbs, Wolfgang Pfützner, Christian Radauer, Barbara Bohle, Clovis Eduardo Galvao, Jose Roberto Aparecido Santos-Pinto, Christian Schwager, Skadi Kull, Frauke Schocker, Jochen Behrends, Wolf-Meinhard Becker, Uta Jappe, Carla Mastrorilli, Salvatore Tripodi, Carlo Caffarelli, Riccardo Asero, Arianna Dondi, Giampaolo Ricci, Carlotta Povesi Dascola, Elisabetta Calamelli, Andrea Di Rienzo Businco, Annamaria Bianchi, Tullio Frediani, Carmen Verga, Iride Dello Iacono, Diego Peroni, Giuseppe Pingitore, Roberto Bernardini, Paolo Maria Matricardi, Heidi Hofer, Claudia Asam, Michael Hauser, Martin Himly, Christof Ebner, Pierrick Lemoine, Karine Jain, Kathy Abiteboul, Monica Arvidsson, Sabina Rak, Inês Mota, Filipe Benito Garcia, Angela Gaspar, Cristina Arêde, Susana Piedade, Graça Sampaio, Graça Pires, Luís Miguel Borrego, Cristina Santa-Marta, Mário Morais-Almeida, Florin-Dan Popescu, Mariana Vieru, Florin-Adrian Secureanu, Rosa Anita Rodrigues Fernandes, Isabel Carrapatoso, Raquel Gomes, Celso Pereira, Ana Todo-Bom, María Cecilia Martín Fernández De Basoa, Javier Barrios Regio, Juan De Castro Cordova, Antón Fernández Ferreiro, Olympia Tsilochristou, Serena Perna, Alina Schwarz, Alexander Rohrbach, Antonio Cappella, Laura Hatzler, Carl-Peter Bauer, Ute Hoffmann, Johannes Forster, Fred Zepp, Antje Schuster, Raffael D’amelio, Ulrich Wahn, Thomas Keil, Susanne Lau, Pol André Apoil, Claire Mailhol, Anne Broué-Chabbert, Agnès Juchet, Alain Didier, Elodie Carrer, Thomas Lanot, Antoine Blancher, Almedina Kurtaj, Christoph Hillebrand, Gerda Fichtinger, Martin Danzer, Christian Gabriel, Theresa Thalhamer, Sandra Scheiblhofer, Josef Thalhamer, Richard Weiss, Martin Wolf, Ulrike Pichler, Teresa Twaroch, Hidenori Yokoi, Toshiro Takai, Alain Didierlaurent, Adriano Mari, Heidrun Behrendt, Angela Neubauer, Frank Stolz, Fátima Ferreira, Michael Wallner, Sara Carvalho, Tatiana Lourenço, Joana Cosme, Fátima Cabral Duarte, Amélia Spínola Santos, Ana Célia Costa, Manuel Pereira Barbosa, Eva Klinglmayr, Bettina Schweidler, Lisa Lueftenegger, Stephanie Moser, Patrick Doppler, Gertie J. Oostingh, Arne Bathke, Joerg Zumbach, Petr Panzner, Martina Vachova, Tomas Vlas, Marek Maly, Daniela Posa, Stephanie Hofmaier, Philippe Stock, Linus Grabenhenrich, Kuan-Wei Chen, Yvonne Resch, Susanne Vrtala, Rudolf Valenta, Tamar Abramidze, Nino Lomidze, Maia Gotua, Austeja Dapkeviciute, Ruta Einikyte, Jolita Norkuniene, Laima Skrickiene, Asta Miskiniene, Violeta Kvedariene, Maximilian Schiener, Carmen Moreno-Aguilar, Gunilla Pietsch, Mareike Mc Intyre, Lea Schwarze, Dennis Rußkamp, Edzard Spillner, Ulf Darsow, Carsten Schmidt-Weber, Simon Blank, Cyril Longé, Andrea Brazdova, Jean-Louis Brunet, Claire Schwartz, Bruno Girodet, François Lavaud, Joelle Birnbaum, Nhân Pham Thi, Magalie Duchateau, Julia Chamot-Rooke, Laurence Guilloux, Marie-Ange Selva, Rémy Couderc, Hélène Sénéchal, Jean-Pierre Sutra, Pascal Poncet, Steffen Augustin, Linda Pump, Martin Wald, Thomas Eichhorn, Frank Fischer, Christoph Willers, Michaela Miehe, Melanie Plum, Sara Wolf, Frederic Jabs, Tim Raiber, Frank Bantleon, Henning Seismann, Thilo Jakob, Danijela Apostolovic, Anh Thu Tran, Sara Sanchez-Vidaurre, Tanja Cirkovic Velickovic, Maria Starkhammar, Carl Hamsten, Marianne Van Hage, Pawel Dubiela, Piotr Humeniuk, Sabine Pfeifer, Merima Bublin, Tomasz Borowski, Karin Hoffmann-Sommergruber, Martie C. M. Verschuren, Shanna Bastiaan-Net, Defien Depoortere, Kay Foetisch, Stephan Scheurer, Harry J Wichers, Theo Noij, Nikki M.E. Van Uden, Karel Vandenberghe, Harry J. Wichers, Theo H. M. Noij, Anargyros Roulias, Maria Alejandra Parigiani, Linda Ahammer, Sarina Grutsch, Martin Tollinger, Raquel Moya, Mª Angeles López-Matas, Raquel Reyes, Jerónimo Carnés, Colette Larré, Hélène Rogniaux, Roberta Lupi, Sandra Denery-Papini, Isabel Maria Pablos, Stephanie Eichhorn, Yoan Machado, Jung-Won Park, Naveen Arora, Stefan Vieths, Charlene Tanaka, Florence Pineau, Martine Drouet, Etienne Beaudouin, Susan Altenbach, Hamza Mameri, Chantal Brossard, Jean Charles Gaudin, Denise Anne Moneret-Vautrin, Evelyne Paty, Olivier Tranquet, Stefania Masci, Denise-Anne Moneret-Vautrin, Arnd Petersen, Marisa Böttger, Sandra Rennert, Susanne Krause, Martin Ernst, Thomas Gutsmann, Johann Bauer, Buko Lindner, Stef Koppelman, Shyamali Jayasena, Dion Luykx, Erik Schepens, Govardus De Jong, Tom Isleib, Julie Nordlee, Joe Baumert, Steve Taylor, Soheila Maleki, Chiara Palladino, Sofía Sirvent, Alba Angelina, Thomas Eiwegger, Oscar Palomares, Heimo Breiteneder, Mathilde Claude, Grégory Bouchaud, Marie Bodinier, Robin Korte, Julia Bräcker, Jens Brockmeyer, Rie Satoh, Reiko Teshima, Angelika Tscheppe, Dieter Palmberger, Reingard Grabherr, Marianne Raith, Linda Sonnleitner, Doris Zach, Konrad Woroszylo, Margit Focke-Tejkl, Herbert Wank, Thorsten Graf, Annette Kuehn, Ines Swoboda, Sara Huber, Fabienne Gay-Crosier, Dominika Polak, Birgit Nagl, Claudia Kitzmüller, Nazanin Samadi, Rene Geyeregger, Beatrice Jahn-Schmid, Ariel Gomez, Jaana Haka, Liisa Hattara, Marika Heikkinen, Merja H Niemi, Juha Rouvinen, Petri Saviranta, Pekka Mattila, Kristiina Takkinen, Marja-Leena Laukkanen, Isabel Pablos, Bianca Kastner, Mira Silar, Julij Selb, Rok Kogovsek, Mitja Kosnik, Peter Korosec, Leticia Pestana, Alcinda Campos Melo, Ana Mendes, Maria Elisa Pedro, Maria Conceição Pereira Santos, Françoise Bienvenu, Claire Goursaud, Lorna Garnier, Sandrine Jacquenet, Michaël Degaud, Sébastien Viel, Annick Barre, Pierre Rougé, Jacques Bienvenu, Joana Vitte, Amel Bensalah, Isabelle Cleach, Laurent Mousseau, Chantal Agabriel, Valérie Liabeuf, Joëlle Birnbaum, Jean-Louis Mège, James Gardner, Minal Gandhi, Harsha Kariyawasam, Giuseppina Rotiroti, Frederico Regateiro, Emília Faria, Johannes Martin Schmid, Ronald Dahl, Hans Juergen Hoffmann, Letícia Pestana, Diana Silva, Teresa Vieira, Ana Maria Pereira, André Moreira, Luís Delgado, Sara Prates, Cátia Alves, Elena Finelli, Paula Leiria Pinto, Bárbara Kong Cardoso, Cíntia Cruz, Filipa Semedo, Elza Tomaz, Filipe Inácio, Santanu Maity, Ivona Baricevic-Jones, Justin T. Marsh, Phil E. Johnson, Anuradha Balasundaram, Anya-May Hope, Aafke Taekema, Angela Simpson, Aida Semic-Jusufagic, E. N. Clare Mills, Gourdon Dubois Nelly, Sellam Laetitia, Pereira Bruno, Michaud Elodie, Messaoudi Khaled, Evrard Bertrand, Fauquert Jean-Luc, Richard E. Goodman, Elena Rodríguez Plata, Luis Amaral, Borja Bartolomé, Alice Coimbra, Jose L Placido, Carmen Saviana Ganea, Carol Ann Costello, Martin Sorensen, Clare Mills, Adrian Rogers, Aage Otherhals, Tanja Kalic, Isabella Ellinger, Eva Waltl, Verena Niederberger-Leppin, Dawid Szczepankiewicz, Ewa Pruszynska-Oszmalek, Marek Skrzypski, Krzysztof W. Nowak, Aleksandra Szczepankiewicz, Gwang-Cheon Jang, Iva Markovic, Andreas Borowski, Tina Vetter, Andreas Wohlmann, Michael Kuepper, Karlheinz Friedrich, Ibon Eguiluz Gracia, Anthony Bosco, Ralph Dollner, Guro Reinholt Melum, Anya C Jones, Maria Lexberg, Patrick G Holt, Espen Sønderaal Bækkevold, Frode Lars Jahnsen, Paulina Sobkowiak, Marta Rachel, Beata Narozna, Dorota Jenerowicz, Witold Swiatowy, Anna Breborowicz, Reinhard Nestelbacher, and Hiroyuki Fukui
Subjects: Immunologic diseases. Allergy, RC581-607
Abstract: Table of contents ORAL ABSTRACTS Symposium 1: Biochemistry, structure and environment of the allergen: what makes a protein an allergen? O1 Two cell-membrane peptidases carrying galactose-alpha-1,3-galactose are implicated in delayed anaphylactic reactions upon pork kidney ingestion in patients with IgE-antibodies to alpha-Gal Christiane Hilger, Kyra Swiontek, Jörg Fischer, François Hentges, Christiane Lehners, Martine Morisset, Bernadette Eberlein, Tilo Biedermann, Markus Ollert O2 Structure solution of Pla l 1 suggests similar folding of Ole e 1-like family members but distinct immunological properties Sabrina Wildner, Teresa Stemeseder, Regina Freier, Peter Briza, Roland Lang, Eva Batanero, Mayte Villalba, Jonas Lidholm, Thomas Hawranek, Fatima Ferreira, Hans Brandstetter, Gabriele Gadermaier Symposium 2: New allergen molecules in the spotlight O3 Identification of the cysteine protease Amb a 11 as a novel major allergen from short ragweed (Ambrosia artemisiifolia) Philippe Moingeon, Rachel Groeme, Julien Bouley, Véronique Bordas, Maxime Le Mignon, Laetitia Bussières, Aurélie Lautrette, Laurent Mascarell, Vincent Lombardi, Véronique Baron-Bodo, Henri Chabre, Thierry Batard, Emmanuel Nony O4 Production and characterization of polybia paulista recombinant antigen 5: a valuable diagnostic tool Karine Marafigo De Amicis, Alexandra Sayuri Watanabe, Daniele Danella Figo, José Roberto Aparecido Dos Santos-Pinto, Mario Sergio Palma, Fabio Fernandes Morato Castro, Jorge Kalil, Therese Wohlschlager, Peter Briza, Sabrina Wildner, Fatima Ferreira-Briza, Gabriele Gadermaier, Keity Souza Santos Symposium 3: Progress in molecular and cellular diagnosis O5 Basophil activation test with recombinant Pru p 3; identifying genuine peach allergic patients Margaretha Faber, Athina Van Gasse, Vito Sabato, Margo M. Hagendorens, Chris H. Bridts, Luc S. De Clerck, Araceli Diaz Perales, Didier Ebo O6 Nanofluidic technology enables rapid, near-patient quantification of allergen-specific IgE Petra Zavadakova, Aurélie Buchwalder, Fabien Rebeaud, Iwan Märki Symposium 4: Relevance of molecular diagnostics for intervention and treatment O7 Longitudinal analysis of Bet v 1-specific epitope repertoires during birch pollen immunotherapy Barbara Gepp, Nina Lengger, Christian Möbs, Wolfgang Pfützner, Christian Radauer, Barbara Bohle O8 A natural CCD-free tool: is polistes sp. venom suitable for polybia paulista diagnosis and therapy? Karine Marafigo De Amicis, Alexandra Sayuri Watanabe, Clovis Eduardo Galvao, Daniele Danella Figo, Jose Roberto Aparecido Santos-Pinto, Mario Sergio Palma, Fabio Fernandes Morato Castro, Jorge Kalil, Fatima Ferreira, Gabriele Gadermaier, Keity Souza Santos Symposium 5: The advent of molecular allergology in epidemiology O9 Peanut oleosins: from identification to diagnostic testing Christian Schwager, Skadi Kull, Frauke Schocker, Jochen Behrends, Wolf-Meinhard Becker, Uta Jappe O10 Endotypes of oral allergy syndrome in childhood: a molecular diagnostic approach Carla Mastrorilli, Salvatore Tripodi, Carlo Caffarelli, Riccardo Asero, Arianna Dondi, Giampaolo Ricci, Carlotta Povesi Dascola, Elisabetta Calamelli, Andrea Di Rienzo Businco, Annamaria Bianchi, Tullio Frediani, Carmen Verga, Iride Dello Iacono, Diego Peroni, Giuseppe Pingitore, Roberto Bernardini, Paolo Maria Matricardi Symposium 6: Molecular AIT: which approaches will make it to market? O11 Mbc4: an innovative molecule to tackle birch pollen and concomitant food allergies Heidi Hofer, Claudia Asam, Michael Hauser, Peter Briza, Martin Himly, Christof Ebner, Fatima Ferreira O12 Challenges and solutions associated with the production of recombinant Bet v 1 allergen as a therapeutic protein Emmanuel Nony, Maxime Le Mignon, Pierrick Lemoine, Karine Jain, Kathy Abiteboul, Monica Arvidsson, Sabina Rak, Philippe Moingeon Clinical Cases: Breakthroughs and headaches from CRD: interactive session CC1 Anaphylaxis caused by lipid transfer proteins: a complex clinical pattern syndrome Inês Mota, Filipe Benito Garcia, Angela Gaspar, Cristina Arêde, Susana Piedade, Graça Sampaio, Graça Pires, Luís Miguel Borrego, Cristina Santa-Marta, Mário Morais-Almeida CC2 IgE sensitization profile in a patient with asteraceae pollen-exotic fruits association Florin-Dan Popescu, Mariana Vieru, Florin-Adrian Secureanu CC3 Food-dependent: exercise induced anaphylaxis. Which component to blame? Rosa Anita Rodrigues Fernandes, Isabel Carrapatoso, Raquel Gomes, Celso Pereira, Ana Todo-Bom CC4 Anaphylaxis to intravenous iron preparations in a patient that tolerates oral administration María Cecilia Martín Fernández De Basoa, Javier Barrios Regio, Juan De Castro Cordova, Antón Fernández Ferreiro CC5 IgE sensitization pattern in an adult patient with oral allergy syndrome to peanuts and pollinosis from southern Romania Florin-Dan Popescu, Mariana Vieru, Florin-Adrian Secureanu CC6 Evidence of specific IgE to plant-derived cross-reactive carbohydrate determinant in a patient with delayed anaphylaxis to red meat Mariana Vieru, Florin-Dan Popescu, Florin-Adrian Secureanu POSTER PRESENTATIONS Poster Session 1: Molecular allergology and epidemiology P1 Atopic children produce stronger and more frequent IgG responses than non-atopic children: longitudinal data from the German MAS birth cohort Olympia Tsilochristou, Serena Perna, Alina Schwarz, Alexander Rohrbach, Antonio Cappella, Laura Hatzler, Carl-Peter Bauer, Ute Hoffmann, Johannes Forster, Fred Zepp, Antje Schuster, Raffael D’amelio, Ulrich Wahn, Thomas Keil, Susanne Lau, Paolo Maria Matricardi P2 The IgG sensitization profiles against 112 allergenic components support the absence of a protective role of IgG in allergic individuals, outside of the context of SIT Pol André Apoil, Claire Mailhol, Anne Broué-Chabbert, Agnès Juchet, Alain Didier, Elodie Carrer, Thomas Lanot, Antoine Blancher P3 The immune response against the timothy grass pollen allergen Phl p 5 in non-allergic humans Almedina Kurtaj, Christoph Hillebrand, Gerda Fichtinger, Martin Danzer, Christian Gabriel, Theresa Thalhamer, Sandra Scheiblhofer, Josef Thalhamer, Richard Weiss P4 Analyzing the cross-reactivity profile of the major ragweed allergen Amb a 1 Martin Wolf, Michael Hauser, Ulrike Pichler, Teresa Twaroch, Gabriele Gadermaier, Christof Ebner, Hidenori Yokoi, Toshiro Takai, Alain Didierlaurent, Adriano Mari, Peter Briza, Heidrun Behrendt, Angela Neubauer, Frank Stolz, Fátima Ferreira, Michael Wallner P5 LTP (Pru p 3) sensitisation in skin prick test: which means in clinical practice? Sara Carvalho, Tatiana Lourenço, Joana Cosme, Fátima Cabral Duarte, Amélia Spínola Santos, Ana Célia Costa, Manuel Pereira Barbosa P6 IgE profiles, allergen exposure and lifestyle of 501 Austrian pupils: investigation of influences on the development of allergic sensitizations Teresa Stemeseder, Eva Klinglmayr, Bettina Schweidler, Lisa Lueftenegger, Stephanie Moser, Patrick Doppler, Roland Lang, Martin Himly, Gertie J. Oostingh, Arne Bathke, Joerg Zumbach, Thomas Hawranek, Gabriele Gadermaier P7 Molecular profiles of sensitization to perennial inhalant allergens in a middle European region Petr Panzner, Martina Vachova, Tomas Vlas, Marek Maly P8 Evolution of the IgE response to house dust mite allergen molecules in childhood Daniela Posa, Serena Perna, Stephanie Hofmaier, Laura Hatzler, Alexander Rohrbach, Carl-Peter Bauer, Ute Hoffmann, Johannes Forster, Fred Zepp, Antje Schuster, Philippe Stock, Ulrich Wahn, Linus Grabenhenrich, Thomas Keil, Susanne Lau, Kuan-Wei Chen, Yvonne Resch, Susanne Vrtala, Rudolf Valenta, Paolo Maria Matricardi P9 Tropomyosin (Pen a1): to include or not to include in skin prick testing? Joana Cosme, Sara Carvalho, Tatiana Lourenço, Amélia Spínola Santos, Manuel Pereira Barbosa Immunoallergy Department - Hospital de Santa Maria – Centro Hospitalar Lisboa Norte, Lisbon, Portugal, Lisbon, Portugal; Immunoallergy Department - Hospital de Santa Maria – Centro Hospitalar Lisboa Norte, Lisbon, Portugal; Faculdade de Medicina de Lisboa, Lisbon, Portugal P10 Component-resolved IgE profiles in Georgian patients Tamar Abramidze, Nino Lomidze, Maia Gotua P11 Cross reactivity between food and pollen allergens in Lithuania according to spIgE evaluation Austeja Dapkeviciute, Ruta Einikyte, Jolita Norkuniene, Laima Skrickiene, Asta Miskiniene, Violeta Kvedariene P12 Distribution of inhalant allergy in the population of Lithuania Ruta Einikyte, Austeja Dapkeviciute, Jolita Norkuniene, Laima Skrickiene, Asta Miskiniene, Violeta Kvedariene Poster Session 2: Allergen molecules: identification, characterization, structure and function P13 Interference of antigen 5-based cross-reactivity in the diagnosis of hymenoptera venom allergy Maximilian Schiener, Bernadette Eberlein, Carmen Moreno-Aguilar, Gunilla Pietsch, Mareike Mc Intyre, Lea Schwarze, Dennis Rußkamp, Tilo Biedermann, Edzard Spillner, Ulf Darsow, Carsten Schmidt-Weber, Markus Ollert, Simon Blank P14 IgE cross-reactivity between European Hymenoptera and Asian hornet (Vespa velutina) venom allergens Cyril Longé, Andrea Brazdova, Jean-Louis Brunet, Claire Schwartz, Bruno Girodet, François Lavaud, Joelle Birnbaum, Nhân Pham Thi, Magalie Duchateau, Julia Chamot-Rooke, Laurence Guilloux, Marie-Ange Selva, Rémy Couderc, Hélène Sénéchal, Jean-Pierre Sutra, Pascal Poncet P15 Carbohydrate composition of house dust mite extracts and major group 1 and group 2 allergens Steffen Augustin, Linda Pump, Martin Wald, Thomas Eichhorn, Frank Fischer, Christoph Willers P16 Specificity of monoclonal antibodies against cross-reactive carbohydrate determinants Michaela Miehe, Melanie Plum, Sara Wolf, Frederic Jabs, Tim Raiber, Frank Bantleon, Henning Seismann, Thilo Jakob, Edzard Spillner P17 Red meat allergic patients have a selective IgE response to the a-Gal glycan Danijela Apostolovic, Anh Thu Tran, Sara Sanchez-Vidaurre, Tanja Cirkovic Velickovic, Maria Starkhammar, Carl Hamsten, Marianne Van Hage P18 Specificity of non-specific lipid transfer proteins and influence of the ligands on their three-dimensional structure Pawel Dubiela, Piotr Humeniuk, Sabine Pfeifer, Merima Bublin, Tomasz Borowski, Karin Hoffmann-Sommergruber P19 Real-time PCR analysis of Pru av 1 and Pru av 3 allergens Martie C.M. Verschuren, Shanna Bastiaan-Net, Defien Depoortere, Kay Foetisch, Stephan Scheurer, Harry J Wichers, Theo Noij P20 Specificity of anti-Pru av 1 antibodies for the detection of Pru av 1 isoallergens Martie C.M. Verschuren, Shanna Bastiaan-Net, Nikki M.E. Van Uden, Karel Vandenberghe, Kay Foetisch, Stephan Scheurer, Harry J. Wichers H.J., Theo H.M. Noij P21 Enhancing recombinant production yield of Bet v 1 through codon usage harmonization Anargyros Roulias, Maria Alejandra Parigiani, Heidi Hofer, Claudia Asam, Christof Ebner, Fátima Ferreira P22 Structural and dynamic insights into the world of PR-10 allergens Linda Ahammer, Sarina Grutsch, Martin Tollinger Poster Session 3: Allergen molecules: identification, characterization, structure and function P23 Purification of polcalcin from different pollen allergenic sources by antibody-affinity chromatography Raquel Moya, Mª Angeles López-Matas, Raquel Reyes, Jerónimo Carnés P24 Variations of wheat allergens in cultivars measured through a targeted quantitative mass spectrometry approach Colette Larré, Hélène Rogniaux, Roberta Lupi, Sandra Denery-Papini P25 Art v 1, Amb a 4 and Par h 1 defensin-like proteins share similar structural features but distinct immunological and allergenic properties Isabel Maria Pablos, Stephanie Eichhorn, Yoan Machado, Peter Briza, Christof Ebner, Jung-Won Park, Alain Didierlaurent, Naveen Arora, Stefan Vieths, Gabriele Gadermaier, Fatima Ferreira P26 Homogeneity or diversity of IgE-binding proteins in wheat dependant exercise induced anaphylaxis? Sandra Denery-Papini, Charlene Tanaka, Florence Pineau, Roberta Lupi, Martine Drouet, Etienne Beaudouin, Martine Morisset, Susan Altenbach P27 Deciphering the role of disulfide bonds and of repetitive epitopes in immunoglobulin E binding to wheat gliadins Sandra Denery-Papini, Hamza Mameri, Chantal Brossard, Roberta Lupi, Florence Pineau, Jean Charles Gaudin, Denise Anne Moneret-Vautrin, Etienne Beaudouin, Evelyne Paty, Martine Drouet, Olivier Tranquet, Colette Larré P28 Assessment of the allergenicity of soluble fractions from bread and durum wheats genotypes Roberta Lupi, Stefania Masci, Olivier Tranquet, Denise-Anne Moneret-Vautrin, Sandra Denery-Papini, Colette Larré P29 Isolation and characterization of Ara h 12 and Ara h 13: defensins, a novel class of peanut allergens Skadi Kull, Arnd Petersen, Marisa Böttger, Sandra Rennert, Wolf-Meinhard Becker, Susanne Krause, Martin Ernst, Thomas Gutsmann, Johann Bauer, Buko Lindner, Uta Jappe P30 Allergenicity attributes of different peanut market types Stef Koppelman, Shyamali Jayasena, Dion Luykx, Erik Schepens, Danijela Apostolovic, Govardus De Jong, Tom Isleib, Julie Nordlee, Joe Baumert, Steve Taylor, Soheila Maleki P31 The impact of peanut lipids on Ara h 1-induced immune responses in monocytes-derived dendritic cells Chiara Palladino, Barbara Gepp, Sofía Sirvent, Alba Angelina, Merima Bublin, Christian Radauer, Nina Lengger, Thomas Eiwegger, Oscar Palomares, Heimo Breiteneder P32 Compared allergenicity of native and thermally aggregated ovalbumin as large agglomerated particles Mathilde Claude, Roberta Lupi, Grégory Bouchaud, Marie Bodinier, Chantal Brossard, Sandra Denery-Papini P33 Simulation of the gastrointestinal digestion of the hazelnut allergens Cor a 9 and Cor a 11 by an in-vitro model and characterisation of peptidic products including epitopes by HPLC-MS/MS Robin Korte, Julia Bräcker, Jens Brockmeyer P34 Analysis of distribution of rice allergens in brown rice grain and allergenicity of the products containing rice bran Rie Satoh, Reiko Teshima Poster Session 4: Molecular approaches in AIT P35 Production of a recombinant hypoallergenic variant of the major peanut allergen Ara h 2 for allergen-specific immunotherapy Angelika Tscheppe, Dieter Palmberger, Merima Bublin, Christian Radauer, Chiara Palladino, Barbara Gepp, Nina Lengger, Reingard Grabherr, Heimo Breiteneder P36 Mutagenesis of amino acids critical for calcium-binding leads to the generation of a hypoallergenic Phl p 7 variant Marianne Raith, Linda Sonnleitner, Doris Zach, Konrad Woroszylo, Margit Focke-Tejkl, Herbert Wank, Thorsten Graf, Annette Kuehn, Ines Swoboda P37 Are birch pollen allergen immunotherapy induced blocking antibodies protective for cross-reactive allergens? Claudia Asam, Sara Huber, Heidi Hofer, Roland Lang, Thomas Hawranek, Fátima Ferreira, Michael Wallner P38 High success of 58 subcutaneous immunotherapy for pets allergy in a polyallergic cohort of patients: a component resolved individually adapted treatment (CRIAT) Fabienne Gay-Crosier P39 Neutrophils are potential antigen presenting cells in IgE- mediated allergy Dominika Polak, Birgit Nagl, Claudia Kitzmüller, Barbara Bohle P40 Characterization of allergen-specific CD8+ T cells in type I allergy Nazanin Samadi, Claudia Kitzmüller, Rene Geyeregger, Barbara Bohle, Beatrice Jahn-Schmid Poster Session 5: Molecular and cellular diagnostic tests P41 Nanofluidic-based biosensors allow quantification of total circulating IgE from a drop of blood in 5 minutes Aurélie Buchwalder, Ariel Gomez, Fabien Rebeaud, Iwan Märki P42 Allergen microarray for the analysis of serum IgE binding profile and allergenic activity Jaana Haka, Liisa Hattara, Marika Heikkinen, Merja H Niemi, Juha Rouvinen, Petri Saviranta, Pekka Mattila, Kristiina Takkinen, Marja-Leena Laukkanen P43 Generation of a well-characterized panel of periplaneta americana allergens for component resolved diagnosis Stephanie Eichhorn, Isabel Pablos, Bianca Kastner, Bettina Schweidler, Sabrina Wildner, Peter Briza, Jung-Won Park, Naveen Arora, Stefan Vieths, Gabriele Gadermaier, Fatima Ferreira P44 Improved diagnostic sensitivity of recombinant Api m 1 and Ves v 5 in diagnosis of Hymenoptera venom allergy Mira Silar, Julij Selb, Rok Kogovsek, Mitja Kosnik, Peter Korosec P45 Added value of biomarkers of primary sensitization and cross-reactivity in patients with hymenoptera venom allergy Leticia Pestana, Alcinda Campos Melo, Ana Mendes, Maria Elisa Pedro, Manuel Pereira Barbosa, Maria Conceição Pereira Santos P46 Cosensitization to Alt a 1 and Act d 2: more than a fortuitous association? Françoise Bienvenu, Claire Goursaud, Lorna Garnier, Sandrine Jacquenet, Michaël Degaud, Sébastien Viel, Annick Barre, Pierre Rougé, Jacques Bienvenu, Joana Vitte P47 Molecular diagnosis for peanut allergy: ALFA method performs as well as established methods for Ara h 1, Ara h 2, Ara h 6, Ara h 9 and CCD Amel Bensalah, Isabelle Cleach, Laurent Mousseau, Chantal Agabriel, Valérie Liabeuf, Joëlle Birnbaum, Jean-Louis Mège, Joana Vitte P48 Evaluation of a food challenge service in relation to specific IgE to molecular components in children with suspected peanut allergy James Gardner, Minal Gandhi, Harsha Kariyawasam, Giuseppina Rotiroti P49 Component resolved diagnosis in cereal allergy Isabel Carrapatoso, Celso Pereira, Frederico Regateiro, Emília Faria, Ana Todo-Bom Poster Session 6: Molecular diagnosis in prevention and therapy P50 Pretreatment molecular sensitizations determine the sIgG4 induction during the updosing of SCIT and may be useful to identify clinically relevant additional sensitizations Johannes Martin Schmid, Ronald Dahl, Hans Juergen Hoffmann P51 Usefulness of recombinant latex allergens in immunotherapy’s decision and follow-up Inês Mota, Filipe Benito Garcia, Angela Gaspar, Mário Morais-Almeida P52 Omega-5-gliadin in the diagnosis of wheat-dependent anaphylaxis induced by ibuprofen but not by exercise Joana Cosme, Letícia Pestana, Amélia Spínola Santos, Manuel Pereira Barbosa P53 Food dependent exercise-induced anaphylaxis: a component-resolved and in vitro depletion approach to access IgE cross-reactivity Diana Silva, Teresa Vieira, Ana Maria Pereira, André Moreira, Luís Delgado P54 Olive pollen allergens: what are we missing? Sara Prates, Cátia Alves, Elena Finelli, Paula Leiria Pinto P55 Purified Alt a 1 extract in Alternaria alternata allergy diagnosis Bárbara Kong Cardoso, Cíntia Cruz, Filipa Semedo, Elza Tomaz, Filipe Inácio P56 Use of specific IgE Bos d8 (casein) to aid early introduction of dietary baked milk in children with cows’ milk allergy James Gardner, Santanu Maity, Giuseppina Rotiroti, Minal Gandhi P57 Molecular characterisation and immunoreactivity of a peanut ingredient for use in oral food challenges Ivona Baricevic-Jones, Justin T. Marsh, Phil E. Johnson, Anuradha Balasundaram, Anya-May Hope, Aafke Taekema, Angela Simpson, Aida Semic-Jusufagic, E.N. Clare Mills P58 Specific IgE to recombinant allergens of hazelnut and oral food challenge in children Gourdon Dubois Nelly, Sellam Laetitia, Pereira Bruno, Michaud Elodie, Messaoudi Khaled, Evrard Bertrand, Fauquert Jean-Luc Poster session 7/8: miscellaneous P59 What defines a protein as an allergen? A discussion of sources and sufficiency Richard E. Goodman P60 Cat allergy: relationship between clinical and molecular diagnostic María Cecilia Martín Fernández De Basoa, Antón Fernández Ferreiro, Elena Rodríguez Plata P61 Anaphylaxis to rabbit: the cat came in last Luis Amaral, Borja Bartolomé, Alice Coimbra, Jose L Placido P62 Dog allergy: relationship between clinical and molecular diagnostic María Cecilia Martín Fernández De Basoa, Antón Fernández Ferreiro, Elena Rodríguez Plata P63 Correlation of serum timothy grass-pollen specific IgE levels determined by two immunoblot test systems Mariana Vieru, Florin-Dan Popescu, Florin-Adrian Secureanu, Carmen Saviana Ganea P64 Development of oral food challenge formulations for diagnosis of fish allergy using powdered fish ingredients Carol Ann Costello, Ivona Baricevic-Jones, Martin Sorensen, Clare Mills, Adrian Rogers, Aage Otherhals P65 Fish and peanut allergens interact with plasma membranes of intestinal and bronchial epithelial cells and induce differential gene expression of cytokines and chemokines Tanja Kalic, Isabella Ellinger, Chiara Palladino, Barbara Gepp, Eva Waltl, Verena Niederberger-Leppin, Heimo Breiteneder P66 Interleukin 4 affects fat tissue metabolism and expression of pro-inflammatory factors in isolated rat adipocytes Dawid Szczepankiewicz, Ewa Pruszynska-Oszmalek, Marek Skrzypski, Krzysztof W. Nowak, Aleksandra Szczepankiewicz P67 Ozone induced airway hyperreactivity in PD-L2−/− mice model Gwang-Cheon Jang P68 Thymic stromal lymphopoietin (TSLP) and its receptor as targets for the development of anti-inflammatory inhibitory agents Iva Markovic, Andreas Borowski, Tina Vetter, Andreas Wohlmann, Michael Kuepper, Karlheinz Friedrich P69 The mononuclear phagocyte system in experimentally-induced allergic rhinitis Ibon Eguiluz Gracia, Anthony Bosco, Ralph Dollner, Guro Reinholt Melum, Anya C Jones, Maria Lexberg, Patrick G Holt, Espen Sønderaal Bækkevold, Frode Lars Jahnsen P70 Expression of histamine metabolizing enzymes is increased in allergic children Aleksandra Szczepankiewicz, Paulina Sobkowiak, Marta Rachel, Beata Narozna, Dorota Jenerowicz, Witold Swiatowy, Anna Breborowicz P71 Modifying the glycosylation of human IgE towards oligomannosidic structures does not affect its biological activity Melanie Plum, Sara Wolf, Frank Bantleon, Henning Seismann, Frederic Jabs, Michaela Miehe, Thilo Jakob, Edzard Spillner P72 Flying Labs: an educational initiative to transfer allergy research into high-school settings Michael Wallner, Heidi Hofer, Fatima Ferreira, Reinhard Nestelbacher P73 Clinical significance of antihistamines and Kujin, an anti-allergic Kampo medicine Hiroyuki Fukui
Published: 2016
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48. IgE – the main player of food allergy

Author: Broekman, Henrike C.H., Eiwegger, Thomas, Upton, Julia, and Bøgh, Katrine L.
Published: 2015
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49. Oral immunotherapy for food allergy: what's age got to do with it?

Author: Upton, Julia E. M., primary, Correa, Natasha, additional, and Eiwegger, Thomas, additional
Published: 2022
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50. EAACI statement on the pathogenesis, immunology, and immune-targeted management of the Multisystem Inflammatory Syndrome in Children (MIS-C) or Pediatric Inflammatory Multisystem Syndrome (PIMS).

Author: Feleszko, Wojciech, primary, Okarska-Napierała, Magdalena, additional, Buddingh, Emilie Pauline, additional, Bloomfield, Marketa, additional, Sediva, Anna, additional, Bautista-Rodriguez, Carles, additional, Brough, Helen, additional, Eigenmann, Philippe, additional, Eiwegger, Thomas, additional, Eljaszewicz, Andrzej, additional, Eyerich, Stefanie, additional, Gomez-Casado, Cristina, additional, Fraisse, Alain, additional, Janda, Jozef, additional, Jiménez-Saiz, Rodrigo, additional, Kallinich, Tilmann, additional, Krohn, Inge Kortekaas, additional, Mørtz, Charlotte, additional, RIGGIONI, CARMEN, additional, Sastre, Joaquin, additional, Sokolowska, Milena, additional, Strzelczyk, Ziemowit, additional, Untersmayr, Eva, additional, and Tramper, Gerdien, additional
Published: 2022
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