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3 results on '"Ejarque Martínez L"'

1. A case-control emergency department-based analysis of acute pancreatitis in Covid-19: Results of the UMC-19-S-6

Author

Miró Ò, Llorens P, Jiménez S, Piñera P, Burillo-Putze G, Martín A, Martín-Sánchez FJ, Lambereche J, Alquézar-Arbé A, Jacob J, Noceda J, Cano MJC, Fortuny Bayarri MJ, Marín Porrino JM, Meléndez N, Pérez García C, Brasó Aznar JV, Ponce MC, Díaz Fernández E, Ejarque Martínez L, PEIRÓ A, Tost J, Domínguez MJ, Teigell Muñoz FJ, and González Del Castillo J

Subjects
acute pancreatitis, SARS-Cov-2, incidence, COVID-19, risk factors, clinical characteristics
Abstract

Background/Purpose: We investigated the incidence, risk factors, clinical characteristics and outcomes of acute pancreatitis (AP) in patients with COVID-19 attending the emergency department (ED), before hospitalization. Methods: We retrospectively reviewed all COVID patients diagnosed with AP in 62 Spanish EDs (20% of Spanish EDs, COVID-AP) during the COVID outbreak. We formed two control groups: COVID patients without AP (COVID-non-AP) and non-COVID patients with AP (non-COVID-AP). Unadjusted comparisons between cases and controls were performed regarding 59 baseline and clinical characteristics and four outcomes. Results: We identified 54 AP in 74 814 patients with COVID-19 attending the ED (frequency = 0.72 parts per thousand, 95% CI = 0.54-0.94 parts per thousand). This frequency was lower than in non-COVID patients (2231/1 388 879, 1.61 parts per thousand, 95% CI = 1.54-1.67; OR = 0.44, 95% CI = 0.34-0.58). Etiology of AP was similar in both groups, being biliary origin in about 50%. Twenty-six clinical characteristics of COVID patients were associated with a higher risk of developing AP: abdominal pain (OR = 59.4, 95% CI = 23.7-149), raised blood amylase (OR = 31.8; 95% CI = 1.60-632) and vomiting (OR = 15.8, 95% CI = 6.69-37.2) being the strongest, and some inflammatory markers (C-reactive protein, procalcitonin, platelets, D-dimer) were more increased. Compared to non-COVID-AP, COVID-AP patients differed in 23 variables; the strongest ones related to COVID symptoms, but less abdominal pain was reported, pancreatic enzymes raise was lower, and severity (estimated by BISAP and SOFA score at ED arrival) was higher. The in-hospital mortality (adjusted for age and sex) of COVID-AP did not differ from COVID-non-AP (OR = 1.12, 95% CI = 0.45-245) but was higher than non-COVID-AP (OR = 2.46, 95% CI = 1.35-4.48). Conclusions: Acute pancreatitis as presenting form of COVID-19 in the ED is unusual (

Published
2021

2. Continuous positive airway pressure treatment reduces mortality in patients with ischemic stroke and obstructive sleep apnea: a 5-year follow-up study

Author

Martínez-García MA, Soler-Cataluña JJ, Ejarque-Martínez L, Soriano Y, Román-Sánchez P, Illa FB, Canal JM, and Durán-Cantolla J

Subjects
cardiovascular diseases, nervous system diseases, respiratory tract diseases
Abstract

Obstructive sleep apnea (OSA) is an independent risk factor for stroke, but little is known about the role of continuous positive airway pressure (CPAP) on mortality in patients with stroke.

Published
2009

3. A case-control analysis of stroke in COVID-19 patients: Results of unusual manifestations of COVID-19-study 11.

Author

García-Lamberechts EJ, Miró Ò, Fragiel M, Llorens P, Jiménez S, Piñera P, Burillo-Putze G, Martín A, Martín-Sánchez FJ, Jacob J, Alquézar-Arbé A, Ejarque Martínez L, Rodríguez Miranda B, Ruiz Grinspan M, Domínguez MJ, Teigell Muñoz FJ, Gayoso Martín S, García García Á, Iglesias Vela M, Carbajosa V, Salido Mota M, Marchena González MJ, Agüera Urbano C, Porta-Etessam J, Calvo E, and González Del Castillo J

Subjects
Case-Control Studies, Hospitalization, Humans, Intensive Care Units, Retrospective Studies, Risk Factors, SARS-CoV-2, COVID-19, Stroke epidemiology
Abstract

Objective: We investigated the incidence, predictor variables, clinical characteristics, and stroke outcomes in patients with COVID-19 seen in emergency departments (EDs) before hospitalization., Methods: We retrospectively reviewed all COVID-19 patients diagnosed with stroke during the COVID-19 outbreak in 62 Spanish EDs. We formed two control groups: COVID-19 patients without stroke (control A) and non-COVID-19 patients with stroke (control B). We compared disease characteristics and four outcomes between cases and controls., Results: We identified 147 strokes in 74,814 patients with COVID-19 seen in EDs (1.96‰, 95% confidence interval [CI] = 1.66‰ to 2.31‰), being lower than in non-COVID-19 patients (6,541/1,388,879, 4.71‰, 95% CI = 4.60‰ to 4.83‰; odds ratio [OR] = 0.42, 95% CI = 0.35 to 0.49). The estimated that standardized incidences of stroke per 100,000 individuals per year were 124 and 133 for COVID-19 and non-COVID-19 individuals, respectively (OR = 0.93 for COVID patients, 95% CI = 0.87 to 0.99). Baseline characteristics associated with a higher risk of stroke in COVID-19 patients were hypertension, diabetes mellitus, and previous cerebrovascular and coronary diseases. Clinically, these patients more frequently presented with confusion, decreased consciousness, and syncope and higher D-dimer concentrations and leukocyte count at ED arrival. After adjustment for age and sex, the case group had higher hospitalization and intensive care unit (ICU) admission rates (but not mortality) than COVID-19 controls without stroke (OR = 3.41, 95% CI = 1.27 to 9.16; and OR = 3.79, 95% CI = 1.69 to 8.50, respectively) and longer hospitalization and greater in-hospital mortality than stroke controls without COVID-19 (OR = 1.55, 95% CI = 1.24 to 1.94; and OR = 1.77, 95% CI = 1.37 to 2.30, respectively)., Conclusions: The incidence of stroke in COVID-19 patients presenting to EDs was lower than that in the non-COVID-19 reference sample. COVID-19 patients with stroke had greater need for hospitalization and ICU admission than those without stroke and longer hospitalization and greater in-hospital mortality than non-COVID-19 patients with stroke., (© 2021 Society for Academic Emergency Medicine.)

Published
2021
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