37 results on '"Ekinci Z"'
Search Results
2. Treatment and long-term outcome in primary distal renal tubular acidosis
- Author
-
Lopez-Garcia SC, Emma F, Walsh SB, Fila M, Hooman N, Zaniew M, Bertholet-Thomas A, Colussi G, Burgmaier K, Levtchenko E, Sharma J, Singhal J, Soliman NA, Ariceta G, Basu B, Murer L, Tasic V, Tsygin A, Decramer S, Gil-Peña H, Koster-Kamphuis L, La Scola C, Gellermann J, Konrad M, Lilien M, Francisco T, Tramma D, Trnka P, Yüksel S, Caruso MR, Chromek M, Ekinci Z, Gambaro G, Kari JA, König J, Taroni F, Thumfart J, Trepiccione F, Winding L, Wühl E, Ağbaş A, Belkevich A, Vargas-Poussou R, and Blanchard A
- Subjects
Acidosis, Renal Tubular/complications/genetics/*therapy ,Adolescent ,Adult ,Aged ,Bicarbonates/blood ,Calcium/urine ,Child ,Child, Preschool ,Cohort Studies ,DNA Mutational Analysis ,Deafness/complications/genetics/therapy ,Female ,Genetic Association Studies ,Glomerular Filtration Rate ,Hearing Loss, Sensorineural/complications/genetics/*therapy ,Humans ,Infant ,Infant, Newborn ,Male ,Middle Aged ,Mutation ,Nephrocalcinosis/complications/genetics/therapy ,Rare Diseases/complications ,Vacuolar P - Abstract
BACKGROUND: Primary distal renal tubular acidosis (dRTA) is a rare disorder, and we aimed to gather data on treatment and long-term outcome. METHODS: We contacted paediatric and adult nephrologists through European professional organizations. Responding clinicians entered demographic, biochemical, genetic and clinical data in an online form. RESULTS: Adequate data were collected on 340 patients (29 countries, female 52%). Mutation testing had been performed on 206 patients (61%); pathogenic mutations were identified in 170 patients (83%). The median (range) presentation age was 0.5 (0-54) years and age at last follow-up was 11.0 (0-70.0) years. Adult height was slightly below average with a mean (SD score) of -0.57 (±1.16). There was an increased prevalence of chronic kidney disease (CKD) Stage ≥2 in children (35%) and adults (82%). Nephrocalcinosis was reported in 88%. Nephrolithiasis was more common with SLC4A1 mutations (42% versus 21%). Thirty-six percent had hearing loss, particularly in ATP6V1B1 (88%). The median (interquartile range) prescribed dose of alkali (mEq/kg/day) was 1.9 (1.2-3.3). Adequate metabolic control (normal plasma bicarbonate and normocalciuria) was achieved in 158 patients (51%), more commonly in countries with higher gross domestic product (67% versus 23%), and was associated with higher height and estimated glomerular filtration rate. CONCLUSION: Long-term follow-up from this large dRTA cohort shows an overall favourable outcome with normal adult height for most and no patient with CKD Stage 5. However, 82% of adult patients have CKD Stages 2-4. Importance of adequate metabolic control was highlighted by better growth and renal function but was achieved in only half of patients.
- Published
- 2019
3. Treatment and long-term outcome in primary distal renal tubular acidosis
- Author
-
Lopez-Garcia, S.C., Emma, F., Walsh, S.B., Fila, M., Hooman, N., Zaniew, M., Bertholet-Thomas, A., Colussi, G., Burgmaier, K., Levtchenko, E.N., Sharma, J., Singhal, J., Soliman, N.A., Ariceta, G., Basu, B., Murer, L., Tasic, V., Tsygin, A., Decramer, S., Gil-Pena, H., Koster-Kamphuis, L., La Scola, C., Gellermann, J., Konrad, M., Lilien, M., Francisco, T., Tramma, D., Trnka, P., Yuksel, S., Caruso, M.R., Chromek, M., Ekinci, Z., Gambaro, G., Kari, J.A., Konig, J., Taroni, F., Thumfart, J., Trepiccione, F., Winding, L., Wuhl, E., Agbas, A., Belkevich, A., Vargas-Poussou, R., Blanchard, A., Conti, G., Boyer, O., Dursun, I., Pinarbasi, A.S., Melek, E., Miglinas, M., Novo, R., Mallett, A., Milosevic, D., Szczepanska, M., Wente, S., Cheong, H.I., Sinha, R., Gucev, Z., Dufek, S., Iancu, D., Kleta, R., Schaefer, F., Bockenhauer, D., Lopez-Garcia, S.C., Emma, F., Walsh, S.B., Fila, M., Hooman, N., Zaniew, M., Bertholet-Thomas, A., Colussi, G., Burgmaier, K., Levtchenko, E.N., Sharma, J., Singhal, J., Soliman, N.A., Ariceta, G., Basu, B., Murer, L., Tasic, V., Tsygin, A., Decramer, S., Gil-Pena, H., Koster-Kamphuis, L., La Scola, C., Gellermann, J., Konrad, M., Lilien, M., Francisco, T., Tramma, D., Trnka, P., Yuksel, S., Caruso, M.R., Chromek, M., Ekinci, Z., Gambaro, G., Kari, J.A., Konig, J., Taroni, F., Thumfart, J., Trepiccione, F., Winding, L., Wuhl, E., Agbas, A., Belkevich, A., Vargas-Poussou, R., Blanchard, A., Conti, G., Boyer, O., Dursun, I., Pinarbasi, A.S., Melek, E., Miglinas, M., Novo, R., Mallett, A., Milosevic, D., Szczepanska, M., Wente, S., Cheong, H.I., Sinha, R., Gucev, Z., Dufek, S., Iancu, D., Kleta, R., Schaefer, F., and Bockenhauer, D.
- Abstract
Contains fulltext : 204259.pdf (publisher's version ) (Closed access), BACKGROUND: Primary distal renal tubular acidosis (dRTA) is a rare disorder, and we aimed to gather data on treatment and long-term outcome. METHODS: We contacted paediatric and adult nephrologists through European professional organizations. Responding clinicians entered demographic, biochemical, genetic and clinical data in an online form. RESULTS: Adequate data were collected on 340 patients (29 countries, female 52%). Mutation testing had been performed on 206 patients (61%); pathogenic mutations were identified in 170 patients (83%). The median (range) presentation age was 0.5 (0-54) years and age at last follow-up was 11.0 (0-70.0) years. Adult height was slightly below average with a mean (SD score) of -0.57 (+/-1.16). There was an increased prevalence of chronic kidney disease (CKD) Stage >/=2 in children (35%) and adults (82%). Nephrocalcinosis was reported in 88%. Nephrolithiasis was more common with SLC4A1 mutations (42% versus 21%). Thirty-six percent had hearing loss, particularly in ATP6V1B1 (88%). The median (interquartile range) prescribed dose of alkali (mEq/kg/day) was 1.9 (1.2-3.3). Adequate metabolic control (normal plasma bicarbonate and normocalciuria) was achieved in 158 patients (51%), more commonly in countries with higher gross domestic product (67% versus 23%), and was associated with higher height and estimated glomerular filtration rate. CONCLUSION: Long-term follow-up from this large dRTA cohort shows an overall favourable outcome with normal adult height for most and no patient with CKD Stage 5. However, 82% of adult patients have CKD Stages 2-4. Importance of adequate metabolic control was highlighted by better growth and renal function but was achieved in only half of patients.
- Published
- 2019
4. Body mass index and complications following major gastrointestinal surgery: A prospective, international cohort study and meta-analysis
- Author
-
Blanco-Colino, R., Lee, S., Kamarajah, S. K., Vasko, P., Kuiper, S. Z., Farina, V., Chapman, S. J., Drake, T. M., Gavagna, L., Pasquali, S., Pata, F., Pellino, G., de la Rosa-Estadella, M., Stellingwerf, M. E., Stijns, R. C. H., Borrellas, A., Golding, D., Ngaage, M., Van Tol, R. R., de Groof, J., de Wilt, H., Bemelman, W. A., Mcnamee, L., Espin-Basany, E., Emre Baki, B., Gecim, I. E., Can Tatar, O., Bach, S., Bhangu, A., Bresges, K., Burke, J., Claireaux, H. A., Fearnhead, N., Fitzgerald, J. E., Gallagher, S., Glasbey, J. C., Gundogan, B., Harrison, E. M., Hernon, J., Khatri, C., Kong, C. Y., Lyons, A., Mohan, M., Morton, D., Pinkney, T. D., Arezzo, A., Foppa, C., Morino, M., Rubbini, M., Selvaggi, F., Sensi, B., Sica, G., Orhalmi, J., Naccari, P., Sgro, A., Burger, B. H. C. M., Fares, D. A., Spijkerman, R., van Elst, T. R., Wiersema, R., Stassen, L. P. S., Rodriguez Garcia, R., Ozkan, B. B., Tavuz, A. I., Demirci, Z. S., Baki, B. E., Choi, P. J., O'Sullivan, H., Salman, M., Simioni, A., Colombo, F., Turati, L., Cazzola, F. E., Gallo, G., Perrotta, G., Papandrea, M., Naccari, P. M., Menduni, N., Rossi, E., Chetta, N., Romeo, F., Giordano, F., Randisi, B., Curletti, G., Kuiper, J., Costa, A., Marcos Rodrigo, A., Sanchez, A., Varo Munoz, A., Martinez Rios, C. E., Aliseda-Jover, D., Fernandez Nieto, D., Alvarez Reyes, I., Dominguez Rodriguez, L. M., Hernandez Ros, M. I., Esteban Sinovas, O., Bartrina Soler, P., Villarejo Campos, P., Laguna Roman, S., Fontanet-Soler, S., Raurich-Leandro, J., Dominguez-Prieto, V., Segura-Sampedro, J. J., Alconchel-Gago, F., Salazar-Garcia, C., Gezen, A. E., Sahin, A., Atasoy, H., Yuksek, B., Arslan, E., Ozmen, B. B., Sen, A. Y., Erol, H. I., Ucar, E., Aktas, M. K., Yurdaor, S. S., Mermer, S., Seyhan, U., Tosun, V., Gunaydin, Y., Ekinci, Z. B., Yazkan, Z., Choi, J., Yeoh, T. S. L., Jones, C. S., Venturini, S., Saat, M. I., Loo, J., Pike, G., Davies, S. C., Kabariti, R., Olivier, J., Hurny, M., Zebrak, R., Machacova, A., Schulzova, M., Smolak, P., Siroka, M., Palyzova, H., Jaros, J., Dusek, T., Simackova, B., Bartos, M., Sotona, O., Pos, M., Karasek, D., Higgins, P., Hacking, S., Arora, E., Coughlan, G., Palanivail, N., Quill, S., Zhang, A. A., Malak, M., Maan, D. S., Cheema, J., Goh, A. W. J., Shamsul Badrin, A. K., Guinness, F., Howard James, N., Neary, A., Sebaoui, S., Gilroy, D., Petrov, G., Craven, K., Macdonald, A., Redmond, A., Brennan, D., Roche, D., O'Dwyer, M., Collins, P., Edwards, S., Doyle, J., Tiedt, L., Arthurs, B., O'Byrne, L., Kiely, A., Glynn, M., Sproule, L., Heaney, A., Li Hi Shing, S., Goh, W., Al-Nasser, Z., Al-Nasser, A., Teh, J. W., De Boni, D., Goldin, E., Ciccioli, E., Vendramin, E., Marchese, N., Bruno, M., Vinci, A., Harder, G., Morandi, V., Magnoli, M., Suppa, A., Palmieri, A., Martorana, M., Sette, M., Balagna, P., Cruciani, C., Corte, M., Ciano, P., Bagaglini, G., Montuori, M., Di Benedetto, L., Arcudi, C., Pezzuto, R., Saraceno, F., Milana, F., Franceschilli, M., Rizzi, A., Sampietro, G., Rampulla, V., Bianco, F., Boschetti, M. E., Ghignone, F., Bianchini, S., Esposto, R., Riva, L., Riva, M., Cannavo, M., Arrigo, A., Giavarini, L., Colombo, E. M., Trompetto, M., Clerico, G., Catalano, M., Dosa, T., El Mabruk, M., Barone, V., Pallara, E., Pasqualoni, M., Caudullo, G., Mastandrea Bonaviri, G. N., Muro, M., Pistola, I., Verardi, L., Ferrara, D., Gerardi, S., Remore, L. M., Belia, F., Del Coco, F., Larotonda, C., Botrugno, E. M., Cammarota, A., Di Girolami, L., Laterza, V., Laurino, A., Paolo, G., Santocchi, P., Puccioni, C., Truma, A., Giardino, F. R., Giuffrida, A., Ripa, M., Cautiero, R., Patturelli, M., Capozzolo, A., Selvaggi, L., Facchiano, A., Milazzo, L. F., Papazachariou, S. K., Pattapola, V., Anania, G., Feo, C., Bellinato, M., Priani, P., Zigiotto, D., Troia, A., Vable, T., Piran, G., Targa, S., Pulpito, S., Tagariello, F., Fasano, A., Anconelli, D., Castiglione, F., Tognolo, L., Lopez, G., Campion, A., Tarantino, M., Sacco, R., Sammarco, G., Palmisano, S., Giacca, M., Rocco, I., Bellio, G., Favero, A., Raimondi, P., Pantalone, M. R., De Nardi, P., Notarnicola, M., Picciariello, A., Licari, L., Parinisi, Z., Fazzotta, S., Ciciliot, M., Reggiani, L., Mariani, F., Aonzo, P., Checcacci, P., Montanelli, P., Guerra, F., Skalamera, I., Staderini, F., Grandi, S., Nelli, T., de Boer, D. V., van der Pool, A. E. M., Janssen, T. L., El-Atmani, S., van Verschuer, V. M. T., Poelman, M., Dronkers, W. J., van Steensel, L., Toorenvliet, B. R., Duinhouwer, L. E., Vermaas, M., Ter Bruggen, F. F. J. A., Hogendoorn, W., van der Harst, E., van Rijckevorsel, V. A. J. I. M., Bayoumy, A. B., Lap, C. R., Gooszen, J. A. H., Abdulrahman, N., de Roy van Zuidewijn, D., de Groof, E. J., Zijlmans, J. L., van Dalen, A. S. H. M., Bos, K., Musters, G. D., Looijen, R. C., Fliers, J. M., Oostendorp, S. E., Mosterd, C. M., Blonk, L., Jurgens, J., Ribbink, M. E., Boom, M. S., Boersma, A. M., Hidding, E., Schmidt, P. A., Mensink, G., Graus, S. A., Gastel, M. D. A., Veenker, C. G. H., Van Heumen, T. M., Slieker, F. J. B., Sedee, W. J. A., Lowensteyn, Y. N., Amelung, F. J., de Guerre, L. E. V. M., Nota, C. L. M. A., Van Dijck, W. P. M., van Wijnbergen, J. W. M., Pronk, A., Kip, M., van der Zee, C., Heiloo, S., Muller, S., Verboeket, B., Oudman, T. S., Zope, S., Gilissen, V., Gommers, J., Cremers, D., Van der Lubbe, M., Smet, M., Ter Weele, K., de Bruin, M., Geerlings, M., Ter Horst, L., Kerimova, N., Pesser, N., Heesakkers, H., de Mees, T., de Gooyer, J. M., Willems, L., Gawria, L., Bonouvrie, D., Harms, J., Eggen, Y., Hengeveld, E., Smeets, H. J., Hoffman, R. P. C., Detmers Blom, F. P. N., Van Bruggen, D., Steup, W. H., Gooiker, G. A., Willems, Y. R., van der Hoeven, A. C., Vallve-Bernal, M., Perez-Gandara, B., Perez, J. L., Caballero Rodriguez, E., Perez Febles, M., Protti Ruiz, G. P., Hidalgo Pujol, M., Alberti Delgado, P., Gil Barrionuevo, E., Anabitarte, O., Caballero, L., Poyato Nunez, F. J., Prado Perez, R., de la Portilla de Juan, F., Fulgencio Barbarin, J., Elorza Echaniz, G., Mitxelena Elosegi, L., Delgado, A. T., Marti Gelonch, L., Gonzalez Arribas, M., De Serra Tejada, I., Alberdi San Roman, I., de Andres Olabarria, U., Fernandez-Domper, L., Perez Costoya, C., Perez Arias, H., Fa Binefa, M., Becerra Nieves, M., Escalona Canal, M. G., Aldrey, I., Vazquez-Gonzalez, I., Falcon Cazas, A., Amarelo Garcia, M., Gonzalez Ruiz, A. A., Garcia Garrido, M., Simon Frapolli, V., Martinez Diaz, J. M., De la Torre Conde, C., Rodrigues Silva, K., Hernandez Kakauridze, S., Lopez Garcia, M. C., Flores Funes, D., Gomez-Lopez de San Roman, C., San Martin Bragado, M., Tejero Pintor, F. J., Pando Ruiz, B., Sanchez Estebanez, E., Roquet Puignero, E., Pla Sero, S., Vela Polanco, F. F., Mirallas Vinas, O., Caro Gonzalez, M. P., Bertelli Puche, J. L., Gonzalez-Martinez, A., Sanchez Cambronero, M., Garcia Torres, A., Dominguez Jimenez, M., de Jesus Rodriguez Perdomo, M., Echazarreta-Gallego, E., Sanchez-Blasco, L., Del Mar Lopez-Cuevas, M., Latras-Cortes, I., Lopez-Vendrell, L., Diaz Padillo, A., Mestres Petit, N., Cruz Reyes, J. A., Fernandez, C., Posada, M., Moratilla Lapena, L., Martin Morales, E., Mate-Mate, P., Garcia Cruz, G., Gorini, L., Rubio-Perez, I., Soldevila-Verdeguer, C., Jimenez-Vinas, C., Luehrman, A., Sena-Ruiz, F., Garcia-Perez, J. M., Plomer-Sanchez, M., Pujol-Cano, N., Jimenez-Segovia, M., Diaz-Jover, P., Pineno-Flores, C., Ambrona-Zafra, D., Gonzalez-Argente, X. F., Jimenez-Morillas, P., Lopez-Marmol, R., Duran-Martinez, M., Gonzalez-Crespo, A., Checa Guillen, M., Valderrama Perez, A., Claramonte Bellmunt, O., Marti Fernandez, R. M., Kasap, S., Soylemez, Z. O. B. B., Bolat, A. B., Aydar, S. E. Y. I., Birgin, B. Z., Coskun, O., Cakir, S. G., Belibagli, Z. O., Herken, M., Erdem, S., Kayacan, S., Kelesoglu, Y., Moran, D., Atalay, H., Kucukdiler, E., Demirci, A., Buyukkasap, C., Kuzey, A., Emral, C., Dogan, H., Cok, H., Durmaz, H., Asma, A., Ergul, B., Kaya, A., Bilicen, G., Gunay, M., Senturk, E., Baskoy, L., Besisik, H. M., Topalan, K., Piraliyev, E., Danalioglu, A. N., Ilbak, A., Yigman, S., Kara, C., Guzel, M., Inci, E. T., Onsal, U., Erel, T., Cetin, S. K., Yekenkurul, E., Kasar, P., Saglam, Z. A., Gursoy, F., Cetinkaya, M., Aktekin, H., Bober, D. N., Mugurtay, Y. S., Koksal, G., Celik, S., Bektur, G., Yildirim, R., Ankarali, T., Guven, H., Yuksel, A., Semiz, A., Cise, S., Tomas, K., Ulusahin, M., Akbulut, F., Tulum, H., Bodur, S., Isler, V. C., Pektas, A. M., Mutlu, D., Mericliler, M., Tansoker, I., Polat, Z. P., Seyrek, N., Beyatli, S., Toto, O. F., Cakaloglu, H. C., Sapci, I., Akpunarli, B., Adiyaman, C., Kobal, B. B., Gok, Z., Benli, S., Turpan, M., Kocapinar, S., Parimli, H., Acar, S., Eger, M., Yilmaz, I., Cengiz, U., Yoruk, I., Mutlu, B., Ulkucu, A., Arukan, C., Kara, B., Gokce, K., Calisgan, B., Demirci, K., Elkatroushi, T., Ayaz, B., Uzun, B., Sivrikaya, T., Goksoy, B., Eroz, E., Celik, B., Canbay Torun, B., Ekin, B., Senay, B. B., Temiz, C., Yilmaz, M., Yasar, C., Cakir, E., Subasi, A., Celik, K., Aksoy, K., Karabulut, E., Altintas, O., Bali, A. N., Ciftci, E., Babaoglu, H., Aljbour, A., Aljbour, I., Akcaoglu, T., Kakil, E., Taskin, O., Taskin, R. B., Topal, U., Huzmeli, E., Caliskan, T., Unal, A. G., Yurekli, A. M., Sari, V., Tutam, D. N., Celen, D., Posteki, G., Demirtas, B., Yildiz, S., Kilic, E., Yalcin, Y., Kurt, A., Gozubuyuk, Y., Huseynova, S., Cinar, S., Calar, S. N., Kurklu, O., Binbuga, M., Ceylan, C., Yavuz, G., Alim, Y. E., Yildirim, N., Yilmaz, S., Onar, D., Aray, E., Ozsipahi, A. C., Koc, G. E., Yetiskin, E., Kocer, M. D., Ozgencil, B., Bahcecioglu, B., Hacioglu, A. D., Bilici, O., Cin, S., Uzunoglu, E. C., Cumen, E. C., Aslan, L., Erozgur, B., Yildiz, S. S., Zengin, T., Kullac, S., Mizan, S. R., Baykan, B., Kopac, O., Karabacak, U., Aytekin, A., Deliktas, T. S., Buyukkarabacak, Y., Uzun, O., Karahan, B., Turkmen, M., Akdogan, A., Uctepe, F., Bandirmali, O., Erdogan, P., Demir, F., Bozkurt, G. K., Yilmaz, T., Sheikh, I. M. I., Orhan, K., Balci, B., Keyif, M. F., Bilgin, S., Cantimer, E., Yaman, S., Akkaya, E., Atesavci, S. N., Arslan, U., Asik, M., Koksal, S., Murtaza, M. I., Mustafa, S., Oun, H., Sam, Z. H., Brogan, A., Zaidi, R., Quinn, K., Taylor, F., Pang, G., Heath, H., Smart, N. J., Home, J., Mauro, D., Noone, T. M., Fenn, J., Sinha, A., Lowe, R., Hutchings, I., Longstaff, L., Smith, A. G., Edwards, J. A., Alcocer, B. P., Oakley, T., Thomas-Davies, M., Hourston, G. J. M., Kankam, H. K. N., Ramana, A., Baker, C., Endo, Y., Wong, C., Anderson, R. G. J., Badran, A., Ali, A., Myers, L., Tippins, F., Stanley, S., Sandison, L., Schofield, E., Delf, J., Rees, S., Anyan-Brown, J., Long, K., Archer, M., Anakwenze, V., Goel, S., Sharma Khatiwada, A., Khan, S., Leafe, O., Lee, J., Embury-Young, Y., Edwards, L., Hazenberg, P., Agrawal, M., Guerero, D., Britton, F., Rejayee, M., Mahesh, S., Khaing, P. H., Baldwin, A., Iyer, S., Gaskell, P., Adlan, A., Cuckow, L., Barmayehvar, B., Rob, T., Ciurleo, C., Mural-Krishnan, S., Jong, N., Carlson, S., Abdelgalil, R., Goble, M., Doshi, A., Ogunleye, O., Marsh, L., Bagley, J., Poacher, A., Cantelo, J., Wylie, J., Govil, S., Hill, F., Beaver, D., Urquhart, A., Rakhimov, I., Raina, V., Clifford, T., Iorga, R., Cartwright, E., Harris, A. J., Shurovi, B., Wadanamby, S., Brown, E., Bradley, C., Ahmad, A., Jeyabraba, S., Hardaman, B., Truss, A., Mohamed, U. S., Kerin, M. J., Reynolds, J., Ridgway, P., Pietrabissa, A., Foschi, D., Sgroi, G., Rosati, G., Benevento, A., Coco, Claudio, Persiani, R., Vasquez, G., Messina, F., De Manzini, N., Innocenti, P., Rosati, R., Altomare, D. F., Sartori, A., Salamone, G., Galleano, R., Cianchi, F., Wijnhoven, B. P. L., van de Ven, A. W. H., de Vos Tot Nederveen Cappel, R. J., de Castro, S. M. M., Meijerink, W. J. H. J., Mulder, I. M., Acherman, Y. I. Z., van Leeuwen, B. L., Schasfoort, R. A., Kloppenberg, F. W. H., Wiezer, R., Consten, E. C. J., Van Grevenstein, W. M. U., Schiphorst, A., Wijffels, N., Uittenbogaart, M., Klinkert, M., Koppe, M., de Hingh, I., Konsten, J., Polat, F., Berends, F., Langenhoff, B., Zimmerman, D., van Engelenburg, T., Vries, J. J. M., Baeten, C. I. M., Bastiaansen, A. J. N. M., van Geloven, A., Khan, I., Girones, J., Barrera Gomez, M., Sanz Ortega, G., Duran Munoz-Cruzado, V. M., Ruiz Montesinos, I., Enriquez-Navascues, J. M., Portugal Porras, V., Baixauli, J., Garcia Florez, L. J., Alonso Goncalves, S., Parajo, A., Sanchez-Guillen, L., Lujan Mompean, J. A., Soria Aledo, V., Arenal, J. J., Blanco Antona, F., Badia, J. M., Roura, J., Garcia Garcia, J., Elia-Guedea, M., Millan, M., Vinas-Salas, J., Garcia-Olmo, D., Prieto-Nieto, M. I., Medina-Fernandez, F. J., Romero-Simo, M., Frasson, M., Espi Macias, A., Tirnaksiz, M. B., Leventoglu, S., Kara, E., Tasci, Y., Pehlivan, M., Guner, A., Ozben, V., Agalar, C., Albayrak, D., Ertekin, C., Oncel, M., Sakman, G., Guler, S. A., Firat, O., Akkucuk, S., Ozbalci, G. S., Sozuer, E. M., Sengul, N., Schizas, A., Horgan, P. G., Singh, B., Harikrishnan, A., Stechman, M., Hayat, J., Coyne, P., Wilson, T., Arun, C., Manvydas, V., Moroni, P., Lo Secco, G., Argenti, F., Romano, F., Calcagno, P., Steccanella, F., Cisternino, G., Bottini, C., Realis Luc, A., Apicella, M., Candilio, G., Gubbiotti, F., De Luca, E., Casagranda, B., Decorato, A., Aquilino, F., Badii, B., Rahmee, C. N. S., Kleine, E., Yauw, S., de Zeeuw, S., Aarts, E., Teixeira da Silva, M., Brueren, L., Bokkerink, G., Schok, T., Graafland, M., Gonzalez de Chaves, P. E., Jimenez-Gomez, L. M., Garcia Galocha, J. L., Palos Campos, M. C., Jimenez Escovar, F., Hernandez-Lizoain, J. L., Monzonis Hernandez, X., Dominguez Sanchez, J. M., Vives-Rodriguez, E., Abrisqueta Carrion, J., Beltran de Heredia, J., Padilla Valverde, D., Alcazar Montero, J. A., Cordoba-Diaz de Laspra, E., Franco Chacon, M., Muriel, P., Pastor-Riquelme, P., Peinado Iribar, B., Alonso Hernandez, N., Costa-Navarro, D., Martinez Chillaron, E., Secilmis, E., Bamac, E., Koc, F., Kayaci Durak, M., Bayram, S., Ekrem, M., Uzun, S., Gok, A. F. K., Gorguner, F., Yildiz, T., Dalci, K., Kilinc, C., Koc, M., Yuksek, M. A., Ersoy, T., Celik, E., Parmar, E., Abuhussein, N., Metcalf, P., Atif, M., Heywood, E., Mayes, J. W., Kelly, M., Mitchell, H., Antoniou, I., Dean, R., Davies, N., Trecarten, S., Henderson, I., Holmes, C., Shuttleworth, R. H., Jindal, A., Hughes, F., Gouda, P., Fleck, R., Hanrahan, M., Karunakaran, P., Chen, J. H., Sykes, M. C., Sethi, R. K., Suresh, S., Patel, P., Patel, M., Varma, R. K., Mushtaq, J., Bolton, W., Khan, T., Morley, R., Favero, N., Adams, R., Thirumal, V., Kennedy, E. D., Ong, K. K., Tan, Y. H., Gabriel, J., Bakhsh, A., Low, J. Y. L., Yener, A., Paraoan, V., Preece, R., Tilston, T. W., Cumber, E., Dean, S., Ross, T., Mccance, E., Amin, H., Satterthwaite, L., Clement, K. D., Gratton, R., Mills, E. D., Chiu, S. M., Hung, G., Rafiq, N. M., Hayes, J. D. B., Robertson, K. L., Dynes, K., Huang, H. C., Assadullah, S., Duncumb, J. W., Moon, R. D. C., Poo, S. X., Mehta, J. K., Joshi, K. R., Callan, R., Norris, J. M., Chilvers, N. J., Keevil, H., Jull, P., Mallick, S., Elf, D., Carr, L., Player, C., Barton, E. C., Martin, A. L., Ratu, S. G., Roberts, E. J., Phan, P. N., Dyal, A. R., Rogers, J. E., Henson, A. D., Reid, N. B., Burke, D., Culleton, G., Lynne, S., Mansoor, S., Brennan, C., Blessed, R., Holloway, C., Hill, A., Goldsmith, T., Mackin, S., Kim, S., Woin, E., Brent, G., Coffin, J., Ziff, O., Momoh, Z., Debenham, R., Ahmed, M., Yong, C. S., Wan, J. C., Copley, H. C., Raut, P., Chaudhry, F. I., Nixon, G., Dorman, C., Tan, R., Kanabar, S., Canning, N., Dolaghan, M., Bell, N., Mcmenamin, M., Chhabra, A., Duke, K., Turner, L., Patel, T., Chew, L. S., Mirza, M., Lunawat, S., Oremule, B., Ward, N., Khan, M., Tan, E. T., Maclennan, D., Mcgregor, R. J., Chisholm, E. G., Griffin, E. J., Bell, L., Hughes, B. A., Davies, J., Haq, H., Ahmed, H., Ungcharoen, N., Whacha, C., Thethi, R., Markham, R. M., Lee, A. H. Y., Batt, E., Bullock, N. P., Francescon, C. T., Davies, J. E., Shafiq, N. M., Zhao, J., Vivekanantham, S., Barai, I., Allen, J. L. Y., Marshall, D. C., Mcintyre, C. J., Wilson, H. C. P., Ashton, A. J., Lek, C., Behar, N., Davis-Hall, M., Seneviratne, N., Esteve, L., Sirakaya, M., Ali, S., Pope, S., Ahn, J. S., Craig-McQuaide, A., Gatfield, W. A., Leong, S., Demetri, A. M., Kerr, A. L., Rees, C., Loveday, J., Liu, S., Wijesekera, M., Maru, D., Attalla, M., Smith, N., Brown, D., Sritharan, P., Shah, A., Charavanamuttu, V., Heppenstall-Harris, G., Ng, K., Raghvani, T., Rajan, N., Hulley, K., Moody, N., Williams, M., Cotton, A., Sharifpour, M., Lwin, K. N., Bright, M., Chitnis, A. R., Abdelhadi, M., Semana, A. D., Morgan, F., Reid, R., Dickson, J., Anderson, L., Mcmullan, R., Ahern, N., Asmadi, A., Anderson, L. B., Lua Boon Xuan, J., Crozier, L., Mcaleer, S., Lees, D. M., Adebayo, A. A., Das, M., Amphlett, A. H., Al-Robeye, A., Valli, A., Khangura, J., Winarski, A., Woodward, H., Gouldthrope, C., Turner, M., Sasapu, K., Tonkins, M., Wild, J. R. L., Robinson, M., Hardie, J., Heminway, R., Narramore, R., Ramjeeawon, N., Hibberd, A., Winslow, F., Ho, W., Chong, B. F., Lim, K., Ho, S., Crewdson, J. A., Singagireson, S., Kalra, N., Koumpa, F., Jhala, H., Soon, W. C., Karia, M., Rasiah, M. G., Xylas, D., Gilbert, H., Sundar-Singh, M., Wills, J., Akhtar, S., Patel, S., Hu, L., Brathwaite-Shirley, C., Nayee, H., Amin, O., Rangan, T., Turner, E. J. H., Mccrann, C., Shepherd, R., Patel, N., Prest-Smith, J., Auyoung, E., Murtaza, A., Coates, A., Prys-Jones, O., King, M., Gaffney, S., Dewdney, C. J., Nehikhare, I., Lavery, J., Bassett, J., Davies, K., Ahmad, K., Collins, A., Acres, M., Egerton, C., Cheng, K., Chen, X., Chan, N., Sheldon, A., Empey, J., Ingram, E., Malik, A., Johnstone, M., Goodier, R., Shah, J. P., Giles, J. E., Sanders, J. A., Mclure, S. W., Pal, S., Rangedara, A., Baker, A. N., Asbjoernsen, C. A., Girling, C., Gray, L., Gauntlett, L., Joyner, C., Qureshi, S., Mogan, Y. P., Ng, J. C. K., Kumar, A. N., Park, J. H., Tan, D., Choo, K. P., Raman, K. P., Buakuma, P., Xiao, C., Govinden, S., Thompson, O. D., Charalambos, M. A., Karsan, R. B., Dogra, T., Bullman, L. M., Dawson, P. M., Frank, A. L., Abid, H., Tung, L., Qureshi, U., Tahmina, A., Matthews, B. W., Harris, R. T., O'Connor, A., Mazan, K., Iqbal, S., Stanger, S. A., Thompson, J. D., Sullivan, J. A. L., Uppal, E., Macaskill, A., Bamgbose, F. A., Neophytou, C., Carroll, A. F., Rookes, C. W., Datta, U., Dhutia, A. J., Rashid, S., Ahmed, N., Lo, T., Bhanderi, S., Blore, C. D., Ahmed, S., Shaheen, H., Abburu, S., Majid, S., Abbas, Z., Talukdar, S. S., Burney, L. J., Patel, J. B., Al-Obaedi, O., Roberts, A. W., Mahboob, S., Sheth, S., Karia, P., Prabhudesai, A., Kow, K., Koysombat, K., Wang, S., Morrison, P., Maheswaran, Y., Keane, P., Copley, P. C., Brewster, O., Xu, G. X., Harries, P., Wall, C., Al-Mousawi, A., Bonsu, S., Cunha, P., Ward, T., Paul, J., Nadanakumaran, K., Tayeh, S., Holyoak, H., Remedios, J., Theodoropoulou, K., Luhishi, A., Jacob, L., Long, F., Atayi, A., Sarwar, S., Parker, O., Harvey, J., Ross, H., Rampal, R., Thomas, G., Vanmali, P., Mcgowan, C., Stein, J., Robertson, V., Carthew, L., Teng, V., Fong, J., Street, A. N., Thakker, C. E., O'Reilly, D., Bravo, M., Pizzolato, A., Khokhar, H. A., Ryan, M., Cheskes, L., Carr, R., Salih, A. E., Bassiony, S., Yuen, R., Chrastek, D., Rosen O'Sullivan, H., Amajuoyi, A., Wang, A., Sitta, O., Wye, J., Qamar, M. A., Major, C., Kaushal, A., Morgan, C., Petrarca, M., Allot, R., Verma, K., Dutt, S., Chilima, C. P., Peroos, S., Kosasih, S. R., Chin, H., Ashken, L., Pearse, R. J., O'Loughlin, R. A., Menon, A., Singh, K., Norton, J., Sagar, R., Jathanna, N., Rothwell, L., Watson, N., Harding, F., Dube, P., Khalid, H., Punjabi, N., Sagmeister, M., Gill, P., Shahid, S., Hudson-Phillips, S., George, D., Ashwood, J., Lewis, T., Dhar, M., Sangal, P., Rhema, I. A., Kotecha, D., Afzal, Z., Syeed, J. A., Prakash, E., Jalota, P., Herron, J., Kimani, L., Delport, A., Shukla, A., Agarwal, V., Parthiban, S., Thakur, H., Cymes, W., Rinkoff, S., Turnbull, J. A., Hayat, M., Darr, S., Khan, U., Lim, J., Higgins, A., Lakshmipathy, G., Forte, B., Canning, E., Jaitley, A., Lamont, J., Toner, E., Ghaffar, A., Mcdowell, M., Salmon, D., O'Carroll, O., Khan, A., Kelly, M. E., Clesham, K., Palmer, C., Lyons, R., Bell, A., Chin, R., Waldron, R. M., Trimble, A., Cox, S. E., Ashfaq, U., Campbell, J., Holliday, R. B. S., Mccabe, G., Morris, F., Priestland, R., Vernon, O. K., Ledsam, A., Vaughan, R., Lim, D., Bakewell, Z. R., Hughes, R. K., Koshy, R. M., Jackson, H. R., Narayan, P., Cardwell, A. E., Jubainville, C. L., Arif, T., Elliott, L. E., Gupta, V., Bhaskaran, G., Odeleye, A., Ahmed, F., Shah, R., Pickard, J., Suleman, Y. N., North, A. S., Mcclymont, L. F., Hussain, N., Ibrahim, I., Ng, G. S., Wong, V., Lim, A. E., Harris, L. N., Tharmachandirar, T., Mittapalli, D., Patel, V., Lakhani, M., Bazeer, H. Z., Narwani, V., Sandhu, K. K., Wingfield, L. R., Gentry, S., Adjei, H., Bhatti, M., Braganza, L., Barnes, J., Mistry, S., Chillarge, G., Stokes, S., Cleere, J., Bucko, A. M., Meek, J., Boxall, N., Heywood, E. G., Wiltshire, J. J., Toh, C., Ward, A. E., Shurovi, B. N., Horth, D., Patel, B. Y., Ali, B., Spencer, T., Axelson, T., Kretzmer, L., Chhina, C., Anandarajah, C., Fautz, T., Horst, C., Thevathasan, A. A., Ng, J. Q., Hirst, F., Brewer, C. F., Logan, A. E., Lockey, J. W., Forrest, P. R., Keelty, N., Wood, A. D., Springford, L. R., Avery, P., Schulz, T. M., Bemand, T. P., Howells, L., Collier, H., Khajuria, A., Tharakan, R. G., Parsons, S., Buchan, A. M., Mcgalliard, R. J., Mason, J. D., Cundy, O. J., Li, N., Redgrave, N. A., Watson, R. P., Pezas, T. P., Dennis, Y. F., Segall, E., Hameed, M., Lynch, A. S., Chamberlain, M., Peck, F. S., Neo, Y. N., Russell, G., Elseedawy, M., Foster, N. L., Soo, Y. H., Puan, L., Dennis, R., Goradia, H., Qureshi, A., Osman, S., Reeves, T., Dinsmore, L., Marsden, M., Lu, Q., Pitts-Tucker, T., Dunn, C. E., Walford, R. A., Heathcote, E., Martin, R., Pericleous, A., Brzyska, K., Reid, K. G., Williams, M. R., Wetherall, N., Mcaleer, E., Thomas, D., Kiff, R., Milne, S., Holmes, M. J. V., Bartlett, J., Lucas de Carvalho, J., Bloomfield, T., Tongo, F., Bremner, R. H., Yong, N., Atraszkiewicz, B. A., Mehdi, A., Tahir, M., Sherliker, G. X. J., Tear, A. K., Pandey, A., Broyd, A., Omer, H. M., Raphael, M., Chaudhry, W. W., Shahidi, S., Jawad, A. S., Gill, C. K., Hindle Fisher, I., Adeleja, I., Clark, I. J., Aidoo-Micah, G. E., Stather, P. W., Salam, G. J., Glover, T. E., Deas, G., Sim, N. K., Obute, R. D., Wynell-Mayow, W. M., Sait, M. S., Mitha, N., de Bernier, G. L., Siddiqui, M., Shaunak, R., Wali, A., Cuthbert, G., Bhudia, R., Webb, E., Shah, S., Ansari, N., Perera, M., Kelly, N., Mcallister, R., Stanley, G. H., Keane, C. P., Shatkar, V., Maxwell-Armstrong, C., Henderson, L. A., Maple, N., Manson, R., Adams, R. D., Semple, E., Mills, M., Daoub, A., Marsh, A., Ramnarine, A., Hartley, J., Malaj, M., Jewell, P. D., Whatling, E. A., Hitchen, N., Chen, M., Goh, B., Fern, J., Rogers, S., Derbyshire, L., Robertson, D. T., Deekonda, P., Abid, A., Harrison, P. L. M., Aildasani, L., Turley, H., Sherif, M. A., Pandey, G., Filby, J. J., Johnston, A., Burke, E., Mohamud, M., Gohil, K., Tsui, A. Y., Singh, R., Lim, S. J., O'Sullivan, K., Mckelvey, L. L., O'Neill, S., Roberts, H. F., Brown, F. S., Cao, Y., Buckle, R. T., Liew, Y., Sii, S., Ventre, C. M., Graham, C. J., Filipescu, T., Yousif, A., Dawar, R., Wright, A., Peters, M., Varley, R., Owczarek, S., Hartley, S., Khattak, M., Iqbal, A., Ali, M., Durrani, B., Narang, Y., Bethell, G. S., Horne, L., Pinto, R., Nicholls, K., Kisyov, I., Torrance, H. D., English, W., Lakhani, S. M., Ashraf, S. F., Venn, M., Elangovan, V., Kazmi, Z., Brecher, J., Sukumar, S., Mastan, A., Mortimer, A., Parker, J., Boyle, J., Elkawafi, M., Beckett, J., Mohite, A., Narain, A., Mazumdar, E., Sreh, A., Hague, A., Weinberg, D., Fletcher, L., Steel, M., Shufflebotham, H., Masood, M., Sinha, Y., Jenvey, C., Kitt, H., Slade, R., Craig, A. R., Deall, C., Reakes, T., Chervenkoff, J., Strange, E., O'Bryan, M., Murkin, C., Joshi, D., Bergara, T., Naqib, S., Wylam, D., Scotcher, S. E., Hewitt, C. M., Stoddart, M. T., Kerai, A., Trist, A. J., Cole, S. J., Knight, C. L., Stevens, S., Cooper, G. E., Ingham, R., Dobson, J., O'Kane, A., Moradzadeh, J., Duffy, A., Henderson, C., Ashraf, S., Mclaughin, C., Hoskins, T. C., Reehal, R. S., Bookless, L. R., Mclean, R. C., Stone, E. J., Wright, E. V., Abdikadir, H. R., Roberts, C., Spence, O., Srikantharajah, M., Ruiz, E. M., Matthews, J. H., Gardner, E., Hester, E., Naran, P., Simpson, R., Minhas, M., Cornish, E., Semnani, S. A., Rojoa, D., Radotra, A., Eraifej, J., Eparh, K., Smith, D. N. E., Mistry, B. D., Hickling, S. L., Din, W., Liu, C., Mithrakumar, P., Mirdavoudi, V., Rashid, M., Mcgenity, C., Hussain, O., Kadicheeni, M., Gardner, H., Anim-Addo, N., Pearce, J., Aslanyan, A., Ntala, C., Sorah, T., Parkin, J., Alizadeh, M., White, A., Edozie, F., Johnston, J., Kahar, A., Navayogaarajah, V., Carter, D., Khonsari, P., Burgess, A., Patel, B., Kong, C., Ponweera, A., Cody, A., Tan, Y., Ng, A. Y. L., Croall, A., Allan, C., Ng, S., Raghuvir, V., Telfer, R., Greenhalgh, A. D., Mckerr, C. N., Edison, M. A., Patel, B. A., Dear, K., Hardy, M. R., Williams, P., Hassan, S., Sajjad, U., O'Neill, E. M., Lopes, S., Healy, L., Jamal, N., Tan, S., Lazenby, D., Husnoo, S. B., Beecroft, S., Sarvanandan, T., Weston, C., Bassam, N., Rabinthiran, S., Hayat, U., Ng, L., Varma, D., Sukkari, M., Mian, A., Omar, A., Kim, J. W., Sellathurai, J., Mahmood, J., O'Connell, C., Bose, R., Heneghan, H., Lalor, P., Matheson, J., Doherty, C., Cullen, C., Cooper, D., Angelov, S., Drislane, C., Smith, A. C. D., Kreibich, A., Palkhi, E., Durr, A., Lotfallah, A., Gold, D., Mckean, E., Dhanji, A., Anilkumar, A., Thacoor, A., Siddiqui, Z. H., Lim, S., Piquet, A., Anderson, S. M., Mccormack, D. R., Gulati, J., Ibrahim, A., Murray, S. E., Walsh, S. L., Mcgrath, A., Ziprin, P., Chua, E. Y., Lou, C. N., Bloomer, J., Paine, H. R., Osei-Kuffour, D., White, C. J., Szczap, A., Gokani, S., Patel, K., Malys, M. K., Reed, A., Torlot, G. E., Cumber, E. M., Charania, A., Ahmad, S., Varma, N., Cheema, H., Austreng, L., Petra, H., Chaudhary, M., Zegeye, M. I., Cheung, F., Coffey, D., Heer, R. S., Singh, S., Seager, E., Cumming, S., Suresh, R. S., Verma, S., Ptacek, I. B., Gwozdz, A. M., Yang, T., Khetarpal, A. A., Shumon, S., Fung, T. M. P., Leung, W., Kwang, P., Chew, L., Loke, W., Curran, A., Chan, C., Mcgarrigle, C., Mohan, K., Cullen, S., Wong, E., Toale, C., Collins, D., Keane, N., Traynor, B. P., Shanahan, D., Yan, A., Jafree, D. J., Topham, C., Mitrasinovic, S., Omara, S., Bingham, G., Lykoudis, P. M., Miranda, B. H., Whitehurst, K., Kumaran, G., Devabalan, Y., Aziz, H., Shoa, M., Dindyal, S., Yates, J. A., Bernstein, I., Rattan, G., Coulson, R., Stezaker, S., Isaac, A., Salem, M., Mcbride, A., Mcfarlane, H., Yow, L., Macdonald, J., Bartlett, R. D., Turaga, S., White, U., Liew, W., Yim, N., Ang, A., Simpson, A., Mcauley, D., Craig, E., Murphy, L., Shepherd, P., Kee, J. Y., Abdulmajid, A., Chung, A., Warwick, H. L., Livesey, A., Holton, P., Theodoreson, M. D., Jenkin, S. L., Turner, J., Entwisle, J. H., Marchal, S. T., O'Connor, S., Blege, H. K., Aithie, J. M., Sabine, L. M., Stewart, G. E., Jackson, S., Kishore, A., Lankage, C. M., Acquaah, F., Joyce, H. L., Mckevitt, K. L., Coffey, C. J., Fawaz, A. S., Dolbec, K. S., O'Sullivan, D. A., Geraghty, J. M., Lim, E., Bolton, L., Fitzpatrick, D., Robinson, C., Ramtoola, T., Collinson, S., Grundy, L., Mcenhill, P. M., Harbhajan Singh, G. S., Loughran, D., Golding, D. M., Keeling, R. E., Williams, R. P., Whitham, R. D. J., Yoganathan, S., Nachiappan, R., Egan, R. J., Owasil, R., Kwan, M. L., He, A., Goh, R. W., Bhome, R., Wilson, H., Teoh, P. J., Raji, K., Jayakody, N., Matthams, J., Chong, J., Luk, C. Y., Greig, R. J., Trail, M., Charalambous, G., Rocke, A. S., Gardiner, N., Bulley, F., Warren, N., Brennan, E., Fergurson, P., Wilson, R., Whittingham, H., Brown, E. J., Khanijau, R., Gandhi, K., Morris, S., Boulton, A. J., Chandan, N., Barthorpe, A. E., Maamari, R., Sandhu, S., Mccann, M., Higgs, L., Balian, V., Reeder, C., Diaper, C., Sale, T., Ali, H., Archer, C. H., Clarke, A. K., Heskin, J., Hurst, P. C., Farmer, J. D., O'Flynn, L. D., Doan, L., Shuker, B. A., Stott, G. D., Vithanage, N. A., Hoban, K. A., Nesargikar, P. N., Kennedy, H. R., Grossart, C. M., Tan, E. S. M., Roy, C. S. D., Sim, P., Leslie, K. E., Sim, D., Abul, M. H., Cody, N., Tay, A. Y., Woon, E., Sng, S., Mah, J., Robson, J., Shakweh, E., Wing, V. C., Mills, H., Li, M. M., Barrow, T. R., Balaji, S., Jordan, H. E. M., Phillips, C., Naveed, H., Hirani, S., Tai, A., Ratnakumaran, R., Sahathevan, A., Shafi, A. M. A., Seedat, M., Weaver, R., Batho, A., Punj, R., Selvachandran, H., Bhatt, N., Botchey, S., Khonat, Z., Brennan, K., Morrison, C. J., Devlin, E., Linton, A., Galloway, E., Mcgarvie, S., Ramsay, N., Mcrobbie, H. D., Whewell, H., Dean, W., Nelaj, S., Eragat, M., Mishra, A., Kane, T., Zuhair, M., Wells, M., Wilkinson, D., Woodcock, N., Sun, E., Aziz, N., Abd Ghaffar, M. K., Bath, M. F., Nepogodiev, D., Coco C. (ORCID:0000-0002-4713-7093), Blanco-Colino, R., Lee, S., Kamarajah, S. K., Vasko, P., Kuiper, S. Z., Farina, V., Chapman, S. J., Drake, T. M., Gavagna, L., Pasquali, S., Pata, F., Pellino, G., de la Rosa-Estadella, M., Stellingwerf, M. E., Stijns, R. C. H., Borrellas, A., Golding, D., Ngaage, M., Van Tol, R. R., de Groof, J., de Wilt, H., Bemelman, W. A., Mcnamee, L., Espin-Basany, E., Emre Baki, B., Gecim, I. E., Can Tatar, O., Bach, S., Bhangu, A., Bresges, K., Burke, J., Claireaux, H. A., Fearnhead, N., Fitzgerald, J. E., Gallagher, S., Glasbey, J. C., Gundogan, B., Harrison, E. M., Hernon, J., Khatri, C., Kong, C. Y., Lyons, A., Mohan, M., Morton, D., Pinkney, T. D., Arezzo, A., Foppa, C., Morino, M., Rubbini, M., Selvaggi, F., Sensi, B., Sica, G., Orhalmi, J., Naccari, P., Sgro, A., Burger, B. H. C. M., Fares, D. A., Spijkerman, R., van Elst, T. R., Wiersema, R., Stassen, L. P. S., Rodriguez Garcia, R., Ozkan, B. B., Tavuz, A. I., Demirci, Z. S., Baki, B. E., Choi, P. J., O'Sullivan, H., Salman, M., Simioni, A., Colombo, F., Turati, L., Cazzola, F. E., Gallo, G., Perrotta, G., Papandrea, M., Naccari, P. M., Menduni, N., Rossi, E., Chetta, N., Romeo, F., Giordano, F., Randisi, B., Curletti, G., Kuiper, J., Costa, A., Marcos Rodrigo, A., Sanchez, A., Varo Munoz, A., Martinez Rios, C. E., Aliseda-Jover, D., Fernandez Nieto, D., Alvarez Reyes, I., Dominguez Rodriguez, L. M., Hernandez Ros, M. I., Esteban Sinovas, O., Bartrina Soler, P., Villarejo Campos, P., Laguna Roman, S., Fontanet-Soler, S., Raurich-Leandro, J., Dominguez-Prieto, V., Segura-Sampedro, J. J., Alconchel-Gago, F., Salazar-Garcia, C., Gezen, A. E., Sahin, A., Atasoy, H., Yuksek, B., Arslan, E., Ozmen, B. B., Sen, A. Y., Erol, H. I., Ucar, E., Aktas, M. K., Yurdaor, S. S., Mermer, S., Seyhan, U., Tosun, V., Gunaydin, Y., Ekinci, Z. B., Yazkan, Z., Choi, J., Yeoh, T. S. L., Jones, C. S., Venturini, S., Saat, M. I., Loo, J., Pike, G., Davies, S. C., Kabariti, R., Olivier, J., Hurny, M., Zebrak, R., Machacova, A., Schulzova, M., Smolak, P., Siroka, M., Palyzova, H., Jaros, J., Dusek, T., Simackova, B., Bartos, M., Sotona, O., Pos, M., Karasek, D., Higgins, P., Hacking, S., Arora, E., Coughlan, G., Palanivail, N., Quill, S., Zhang, A. A., Malak, M., Maan, D. S., Cheema, J., Goh, A. W. J., Shamsul Badrin, A. K., Guinness, F., Howard James, N., Neary, A., Sebaoui, S., Gilroy, D., Petrov, G., Craven, K., Macdonald, A., Redmond, A., Brennan, D., Roche, D., O'Dwyer, M., Collins, P., Edwards, S., Doyle, J., Tiedt, L., Arthurs, B., O'Byrne, L., Kiely, A., Glynn, M., Sproule, L., Heaney, A., Li Hi Shing, S., Goh, W., Al-Nasser, Z., Al-Nasser, A., Teh, J. W., De Boni, D., Goldin, E., Ciccioli, E., Vendramin, E., Marchese, N., Bruno, M., Vinci, A., Harder, G., Morandi, V., Magnoli, M., Suppa, A., Palmieri, A., Martorana, M., Sette, M., Balagna, P., Cruciani, C., Corte, M., Ciano, P., Bagaglini, G., Montuori, M., Di Benedetto, L., Arcudi, C., Pezzuto, R., Saraceno, F., Milana, F., Franceschilli, M., Rizzi, A., Sampietro, G., Rampulla, V., Bianco, F., Boschetti, M. E., Ghignone, F., Bianchini, S., Esposto, R., Riva, L., Riva, M., Cannavo, M., Arrigo, A., Giavarini, L., Colombo, E. M., Trompetto, M., Clerico, G., Catalano, M., Dosa, T., El Mabruk, M., Barone, V., Pallara, E., Pasqualoni, M., Caudullo, G., Mastandrea Bonaviri, G. N., Muro, M., Pistola, I., Verardi, L., Ferrara, D., Gerardi, S., Remore, L. M., Belia, F., Del Coco, F., Larotonda, C., Botrugno, E. M., Cammarota, A., Di Girolami, L., Laterza, V., Laurino, A., Paolo, G., Santocchi, P., Puccioni, C., Truma, A., Giardino, F. R., Giuffrida, A., Ripa, M., Cautiero, R., Patturelli, M., Capozzolo, A., Selvaggi, L., Facchiano, A., Milazzo, L. F., Papazachariou, S. K., Pattapola, V., Anania, G., Feo, C., Bellinato, M., Priani, P., Zigiotto, D., Troia, A., Vable, T., Piran, G., Targa, S., Pulpito, S., Tagariello, F., Fasano, A., Anconelli, D., Castiglione, F., Tognolo, L., Lopez, G., Campion, A., Tarantino, M., Sacco, R., Sammarco, G., Palmisano, S., Giacca, M., Rocco, I., Bellio, G., Favero, A., Raimondi, P., Pantalone, M. R., De Nardi, P., Notarnicola, M., Picciariello, A., Licari, L., Parinisi, Z., Fazzotta, S., Ciciliot, M., Reggiani, L., Mariani, F., Aonzo, P., Checcacci, P., Montanelli, P., Guerra, F., Skalamera, I., Staderini, F., Grandi, S., Nelli, T., de Boer, D. V., van der Pool, A. E. M., Janssen, T. L., El-Atmani, S., van Verschuer, V. M. T., Poelman, M., Dronkers, W. J., van Steensel, L., Toorenvliet, B. R., Duinhouwer, L. E., Vermaas, M., Ter Bruggen, F. F. J. A., Hogendoorn, W., van der Harst, E., van Rijckevorsel, V. A. J. I. M., Bayoumy, A. B., Lap, C. R., Gooszen, J. A. H., Abdulrahman, N., de Roy van Zuidewijn, D., de Groof, E. J., Zijlmans, J. L., van Dalen, A. S. H. M., Bos, K., Musters, G. D., Looijen, R. C., Fliers, J. M., Oostendorp, S. E., Mosterd, C. M., Blonk, L., Jurgens, J., Ribbink, M. E., Boom, M. S., Boersma, A. M., Hidding, E., Schmidt, P. A., Mensink, G., Graus, S. A., Gastel, M. D. A., Veenker, C. G. H., Van Heumen, T. M., Slieker, F. J. B., Sedee, W. J. A., Lowensteyn, Y. N., Amelung, F. J., de Guerre, L. E. V. M., Nota, C. L. M. A., Van Dijck, W. P. M., van Wijnbergen, J. W. M., Pronk, A., Kip, M., van der Zee, C., Heiloo, S., Muller, S., Verboeket, B., Oudman, T. S., Zope, S., Gilissen, V., Gommers, J., Cremers, D., Van der Lubbe, M., Smet, M., Ter Weele, K., de Bruin, M., Geerlings, M., Ter Horst, L., Kerimova, N., Pesser, N., Heesakkers, H., de Mees, T., de Gooyer, J. M., Willems, L., Gawria, L., Bonouvrie, D., Harms, J., Eggen, Y., Hengeveld, E., Smeets, H. J., Hoffman, R. P. C., Detmers Blom, F. P. N., Van Bruggen, D., Steup, W. H., Gooiker, G. A., Willems, Y. R., van der Hoeven, A. C., Vallve-Bernal, M., Perez-Gandara, B., Perez, J. L., Caballero Rodriguez, E., Perez Febles, M., Protti Ruiz, G. P., Hidalgo Pujol, M., Alberti Delgado, P., Gil Barrionuevo, E., Anabitarte, O., Caballero, L., Poyato Nunez, F. J., Prado Perez, R., de la Portilla de Juan, F., Fulgencio Barbarin, J., Elorza Echaniz, G., Mitxelena Elosegi, L., Delgado, A. T., Marti Gelonch, L., Gonzalez Arribas, M., De Serra Tejada, I., Alberdi San Roman, I., de Andres Olabarria, U., Fernandez-Domper, L., Perez Costoya, C., Perez Arias, H., Fa Binefa, M., Becerra Nieves, M., Escalona Canal, M. G., Aldrey, I., Vazquez-Gonzalez, I., Falcon Cazas, A., Amarelo Garcia, M., Gonzalez Ruiz, A. A., Garcia Garrido, M., Simon Frapolli, V., Martinez Diaz, J. M., De la Torre Conde, C., Rodrigues Silva, K., Hernandez Kakauridze, S., Lopez Garcia, M. C., Flores Funes, D., Gomez-Lopez de San Roman, C., San Martin Bragado, M., Tejero Pintor, F. J., Pando Ruiz, B., Sanchez Estebanez, E., Roquet Puignero, E., Pla Sero, S., Vela Polanco, F. F., Mirallas Vinas, O., Caro Gonzalez, M. P., Bertelli Puche, J. L., Gonzalez-Martinez, A., Sanchez Cambronero, M., Garcia Torres, A., Dominguez Jimenez, M., de Jesus Rodriguez Perdomo, M., Echazarreta-Gallego, E., Sanchez-Blasco, L., Del Mar Lopez-Cuevas, M., Latras-Cortes, I., Lopez-Vendrell, L., Diaz Padillo, A., Mestres Petit, N., Cruz Reyes, J. A., Fernandez, C., Posada, M., Moratilla Lapena, L., Martin Morales, E., Mate-Mate, P., Garcia Cruz, G., Gorini, L., Rubio-Perez, I., Soldevila-Verdeguer, C., Jimenez-Vinas, C., Luehrman, A., Sena-Ruiz, F., Garcia-Perez, J. M., Plomer-Sanchez, M., Pujol-Cano, N., Jimenez-Segovia, M., Diaz-Jover, P., Pineno-Flores, C., Ambrona-Zafra, D., Gonzalez-Argente, X. F., Jimenez-Morillas, P., Lopez-Marmol, R., Duran-Martinez, M., Gonzalez-Crespo, A., Checa Guillen, M., Valderrama Perez, A., Claramonte Bellmunt, O., Marti Fernandez, R. M., Kasap, S., Soylemez, Z. O. B. B., Bolat, A. B., Aydar, S. E. Y. I., Birgin, B. Z., Coskun, O., Cakir, S. G., Belibagli, Z. O., Herken, M., Erdem, S., Kayacan, S., Kelesoglu, Y., Moran, D., Atalay, H., Kucukdiler, E., Demirci, A., Buyukkasap, C., Kuzey, A., Emral, C., Dogan, H., Cok, H., Durmaz, H., Asma, A., Ergul, B., Kaya, A., Bilicen, G., Gunay, M., Senturk, E., Baskoy, L., Besisik, H. M., Topalan, K., Piraliyev, E., Danalioglu, A. N., Ilbak, A., Yigman, S., Kara, C., Guzel, M., Inci, E. T., Onsal, U., Erel, T., Cetin, S. K., Yekenkurul, E., Kasar, P., Saglam, Z. A., Gursoy, F., Cetinkaya, M., Aktekin, H., Bober, D. N., Mugurtay, Y. S., Koksal, G., Celik, S., Bektur, G., Yildirim, R., Ankarali, T., Guven, H., Yuksel, A., Semiz, A., Cise, S., Tomas, K., Ulusahin, M., Akbulut, F., Tulum, H., Bodur, S., Isler, V. C., Pektas, A. M., Mutlu, D., Mericliler, M., Tansoker, I., Polat, Z. P., Seyrek, N., Beyatli, S., Toto, O. F., Cakaloglu, H. C., Sapci, I., Akpunarli, B., Adiyaman, C., Kobal, B. B., Gok, Z., Benli, S., Turpan, M., Kocapinar, S., Parimli, H., Acar, S., Eger, M., Yilmaz, I., Cengiz, U., Yoruk, I., Mutlu, B., Ulkucu, A., Arukan, C., Kara, B., Gokce, K., Calisgan, B., Demirci, K., Elkatroushi, T., Ayaz, B., Uzun, B., Sivrikaya, T., Goksoy, B., Eroz, E., Celik, B., Canbay Torun, B., Ekin, B., Senay, B. B., Temiz, C., Yilmaz, M., Yasar, C., Cakir, E., Subasi, A., Celik, K., Aksoy, K., Karabulut, E., Altintas, O., Bali, A. N., Ciftci, E., Babaoglu, H., Aljbour, A., Aljbour, I., Akcaoglu, T., Kakil, E., Taskin, O., Taskin, R. B., Topal, U., Huzmeli, E., Caliskan, T., Unal, A. G., Yurekli, A. M., Sari, V., Tutam, D. N., Celen, D., Posteki, G., Demirtas, B., Yildiz, S., Kilic, E., Yalcin, Y., Kurt, A., Gozubuyuk, Y., Huseynova, S., Cinar, S., Calar, S. N., Kurklu, O., Binbuga, M., Ceylan, C., Yavuz, G., Alim, Y. E., Yildirim, N., Yilmaz, S., Onar, D., Aray, E., Ozsipahi, A. C., Koc, G. E., Yetiskin, E., Kocer, M. D., Ozgencil, B., Bahcecioglu, B., Hacioglu, A. D., Bilici, O., Cin, S., Uzunoglu, E. C., Cumen, E. C., Aslan, L., Erozgur, B., Yildiz, S. S., Zengin, T., Kullac, S., Mizan, S. R., Baykan, B., Kopac, O., Karabacak, U., Aytekin, A., Deliktas, T. S., Buyukkarabacak, Y., Uzun, O., Karahan, B., Turkmen, M., Akdogan, A., Uctepe, F., Bandirmali, O., Erdogan, P., Demir, F., Bozkurt, G. K., Yilmaz, T., Sheikh, I. M. I., Orhan, K., Balci, B., Keyif, M. F., Bilgin, S., Cantimer, E., Yaman, S., Akkaya, E., Atesavci, S. N., Arslan, U., Asik, M., Koksal, S., Murtaza, M. I., Mustafa, S., Oun, H., Sam, Z. H., Brogan, A., Zaidi, R., Quinn, K., Taylor, F., Pang, G., Heath, H., Smart, N. J., Home, J., Mauro, D., Noone, T. M., Fenn, J., Sinha, A., Lowe, R., Hutchings, I., Longstaff, L., Smith, A. G., Edwards, J. A., Alcocer, B. P., Oakley, T., Thomas-Davies, M., Hourston, G. J. M., Kankam, H. K. N., Ramana, A., Baker, C., Endo, Y., Wong, C., Anderson, R. G. J., Badran, A., Ali, A., Myers, L., Tippins, F., Stanley, S., Sandison, L., Schofield, E., Delf, J., Rees, S., Anyan-Brown, J., Long, K., Archer, M., Anakwenze, V., Goel, S., Sharma Khatiwada, A., Khan, S., Leafe, O., Lee, J., Embury-Young, Y., Edwards, L., Hazenberg, P., Agrawal, M., Guerero, D., Britton, F., Rejayee, M., Mahesh, S., Khaing, P. H., Baldwin, A., Iyer, S., Gaskell, P., Adlan, A., Cuckow, L., Barmayehvar, B., Rob, T., Ciurleo, C., Mural-Krishnan, S., Jong, N., Carlson, S., Abdelgalil, R., Goble, M., Doshi, A., Ogunleye, O., Marsh, L., Bagley, J., Poacher, A., Cantelo, J., Wylie, J., Govil, S., Hill, F., Beaver, D., Urquhart, A., Rakhimov, I., Raina, V., Clifford, T., Iorga, R., Cartwright, E., Harris, A. J., Shurovi, B., Wadanamby, S., Brown, E., Bradley, C., Ahmad, A., Jeyabraba, S., Hardaman, B., Truss, A., Mohamed, U. S., Kerin, M. J., Reynolds, J., Ridgway, P., Pietrabissa, A., Foschi, D., Sgroi, G., Rosati, G., Benevento, A., Coco, Claudio, Persiani, R., Vasquez, G., Messina, F., De Manzini, N., Innocenti, P., Rosati, R., Altomare, D. F., Sartori, A., Salamone, G., Galleano, R., Cianchi, F., Wijnhoven, B. P. L., van de Ven, A. W. H., de Vos Tot Nederveen Cappel, R. J., de Castro, S. M. M., Meijerink, W. J. H. J., Mulder, I. M., Acherman, Y. I. Z., van Leeuwen, B. L., Schasfoort, R. A., Kloppenberg, F. W. H., Wiezer, R., Consten, E. C. J., Van Grevenstein, W. M. U., Schiphorst, A., Wijffels, N., Uittenbogaart, M., Klinkert, M., Koppe, M., de Hingh, I., Konsten, J., Polat, F., Berends, F., Langenhoff, B., Zimmerman, D., van Engelenburg, T., Vries, J. J. M., Baeten, C. I. M., Bastiaansen, A. J. N. M., van Geloven, A., Khan, I., Girones, J., Barrera Gomez, M., Sanz Ortega, G., Duran Munoz-Cruzado, V. M., Ruiz Montesinos, I., Enriquez-Navascues, J. M., Portugal Porras, V., Baixauli, J., Garcia Florez, L. J., Alonso Goncalves, S., Parajo, A., Sanchez-Guillen, L., Lujan Mompean, J. A., Soria Aledo, V., Arenal, J. J., Blanco Antona, F., Badia, J. M., Roura, J., Garcia Garcia, J., Elia-Guedea, M., Millan, M., Vinas-Salas, J., Garcia-Olmo, D., Prieto-Nieto, M. I., Medina-Fernandez, F. J., Romero-Simo, M., Frasson, M., Espi Macias, A., Tirnaksiz, M. B., Leventoglu, S., Kara, E., Tasci, Y., Pehlivan, M., Guner, A., Ozben, V., Agalar, C., Albayrak, D., Ertekin, C., Oncel, M., Sakman, G., Guler, S. A., Firat, O., Akkucuk, S., Ozbalci, G. S., Sozuer, E. M., Sengul, N., Schizas, A., Horgan, P. G., Singh, B., Harikrishnan, A., Stechman, M., Hayat, J., Coyne, P., Wilson, T., Arun, C., Manvydas, V., Moroni, P., Lo Secco, G., Argenti, F., Romano, F., Calcagno, P., Steccanella, F., Cisternino, G., Bottini, C., Realis Luc, A., Apicella, M., Candilio, G., Gubbiotti, F., De Luca, E., Casagranda, B., Decorato, A., Aquilino, F., Badii, B., Rahmee, C. N. S., Kleine, E., Yauw, S., de Zeeuw, S., Aarts, E., Teixeira da Silva, M., Brueren, L., Bokkerink, G., Schok, T., Graafland, M., Gonzalez de Chaves, P. E., Jimenez-Gomez, L. M., Garcia Galocha, J. L., Palos Campos, M. C., Jimenez Escovar, F., Hernandez-Lizoain, J. L., Monzonis Hernandez, X., Dominguez Sanchez, J. M., Vives-Rodriguez, E., Abrisqueta Carrion, J., Beltran de Heredia, J., Padilla Valverde, D., Alcazar Montero, J. A., Cordoba-Diaz de Laspra, E., Franco Chacon, M., Muriel, P., Pastor-Riquelme, P., Peinado Iribar, B., Alonso Hernandez, N., Costa-Navarro, D., Martinez Chillaron, E., Secilmis, E., Bamac, E., Koc, F., Kayaci Durak, M., Bayram, S., Ekrem, M., Uzun, S., Gok, A. F. K., Gorguner, F., Yildiz, T., Dalci, K., Kilinc, C., Koc, M., Yuksek, M. A., Ersoy, T., Celik, E., Parmar, E., Abuhussein, N., Metcalf, P., Atif, M., Heywood, E., Mayes, J. W., Kelly, M., Mitchell, H., Antoniou, I., Dean, R., Davies, N., Trecarten, S., Henderson, I., Holmes, C., Shuttleworth, R. H., Jindal, A., Hughes, F., Gouda, P., Fleck, R., Hanrahan, M., Karunakaran, P., Chen, J. H., Sykes, M. C., Sethi, R. K., Suresh, S., Patel, P., Patel, M., Varma, R. K., Mushtaq, J., Bolton, W., Khan, T., Morley, R., Favero, N., Adams, R., Thirumal, V., Kennedy, E. D., Ong, K. K., Tan, Y. H., Gabriel, J., Bakhsh, A., Low, J. Y. L., Yener, A., Paraoan, V., Preece, R., Tilston, T. W., Cumber, E., Dean, S., Ross, T., Mccance, E., Amin, H., Satterthwaite, L., Clement, K. D., Gratton, R., Mills, E. D., Chiu, S. M., Hung, G., Rafiq, N. M., Hayes, J. D. B., Robertson, K. L., Dynes, K., Huang, H. C., Assadullah, S., Duncumb, J. W., Moon, R. D. C., Poo, S. X., Mehta, J. K., Joshi, K. R., Callan, R., Norris, J. M., Chilvers, N. J., Keevil, H., Jull, P., Mallick, S., Elf, D., Carr, L., Player, C., Barton, E. C., Martin, A. L., Ratu, S. G., Roberts, E. J., Phan, P. N., Dyal, A. R., Rogers, J. E., Henson, A. D., Reid, N. B., Burke, D., Culleton, G., Lynne, S., Mansoor, S., Brennan, C., Blessed, R., Holloway, C., Hill, A., Goldsmith, T., Mackin, S., Kim, S., Woin, E., Brent, G., Coffin, J., Ziff, O., Momoh, Z., Debenham, R., Ahmed, M., Yong, C. S., Wan, J. C., Copley, H. C., Raut, P., Chaudhry, F. I., Nixon, G., Dorman, C., Tan, R., Kanabar, S., Canning, N., Dolaghan, M., Bell, N., Mcmenamin, M., Chhabra, A., Duke, K., Turner, L., Patel, T., Chew, L. S., Mirza, M., Lunawat, S., Oremule, B., Ward, N., Khan, M., Tan, E. T., Maclennan, D., Mcgregor, R. J., Chisholm, E. G., Griffin, E. J., Bell, L., Hughes, B. A., Davies, J., Haq, H., Ahmed, H., Ungcharoen, N., Whacha, C., Thethi, R., Markham, R. M., Lee, A. H. Y., Batt, E., Bullock, N. P., Francescon, C. T., Davies, J. E., Shafiq, N. M., Zhao, J., Vivekanantham, S., Barai, I., Allen, J. L. Y., Marshall, D. C., Mcintyre, C. J., Wilson, H. C. P., Ashton, A. J., Lek, C., Behar, N., Davis-Hall, M., Seneviratne, N., Esteve, L., Sirakaya, M., Ali, S., Pope, S., Ahn, J. S., Craig-McQuaide, A., Gatfield, W. A., Leong, S., Demetri, A. M., Kerr, A. L., Rees, C., Loveday, J., Liu, S., Wijesekera, M., Maru, D., Attalla, M., Smith, N., Brown, D., Sritharan, P., Shah, A., Charavanamuttu, V., Heppenstall-Harris, G., Ng, K., Raghvani, T., Rajan, N., Hulley, K., Moody, N., Williams, M., Cotton, A., Sharifpour, M., Lwin, K. N., Bright, M., Chitnis, A. R., Abdelhadi, M., Semana, A. D., Morgan, F., Reid, R., Dickson, J., Anderson, L., Mcmullan, R., Ahern, N., Asmadi, A., Anderson, L. B., Lua Boon Xuan, J., Crozier, L., Mcaleer, S., Lees, D. M., Adebayo, A. A., Das, M., Amphlett, A. H., Al-Robeye, A., Valli, A., Khangura, J., Winarski, A., Woodward, H., Gouldthrope, C., Turner, M., Sasapu, K., Tonkins, M., Wild, J. R. L., Robinson, M., Hardie, J., Heminway, R., Narramore, R., Ramjeeawon, N., Hibberd, A., Winslow, F., Ho, W., Chong, B. F., Lim, K., Ho, S., Crewdson, J. A., Singagireson, S., Kalra, N., Koumpa, F., Jhala, H., Soon, W. C., Karia, M., Rasiah, M. G., Xylas, D., Gilbert, H., Sundar-Singh, M., Wills, J., Akhtar, S., Patel, S., Hu, L., Brathwaite-Shirley, C., Nayee, H., Amin, O., Rangan, T., Turner, E. J. H., Mccrann, C., Shepherd, R., Patel, N., Prest-Smith, J., Auyoung, E., Murtaza, A., Coates, A., Prys-Jones, O., King, M., Gaffney, S., Dewdney, C. J., Nehikhare, I., Lavery, J., Bassett, J., Davies, K., Ahmad, K., Collins, A., Acres, M., Egerton, C., Cheng, K., Chen, X., Chan, N., Sheldon, A., Empey, J., Ingram, E., Malik, A., Johnstone, M., Goodier, R., Shah, J. P., Giles, J. E., Sanders, J. A., Mclure, S. W., Pal, S., Rangedara, A., Baker, A. N., Asbjoernsen, C. A., Girling, C., Gray, L., Gauntlett, L., Joyner, C., Qureshi, S., Mogan, Y. P., Ng, J. C. K., Kumar, A. N., Park, J. H., Tan, D., Choo, K. P., Raman, K. P., Buakuma, P., Xiao, C., Govinden, S., Thompson, O. D., Charalambos, M. A., Karsan, R. B., Dogra, T., Bullman, L. M., Dawson, P. M., Frank, A. L., Abid, H., Tung, L., Qureshi, U., Tahmina, A., Matthews, B. W., Harris, R. T., O'Connor, A., Mazan, K., Iqbal, S., Stanger, S. A., Thompson, J. D., Sullivan, J. A. L., Uppal, E., Macaskill, A., Bamgbose, F. A., Neophytou, C., Carroll, A. F., Rookes, C. W., Datta, U., Dhutia, A. J., Rashid, S., Ahmed, N., Lo, T., Bhanderi, S., Blore, C. D., Ahmed, S., Shaheen, H., Abburu, S., Majid, S., Abbas, Z., Talukdar, S. S., Burney, L. J., Patel, J. B., Al-Obaedi, O., Roberts, A. W., Mahboob, S., Sheth, S., Karia, P., Prabhudesai, A., Kow, K., Koysombat, K., Wang, S., Morrison, P., Maheswaran, Y., Keane, P., Copley, P. C., Brewster, O., Xu, G. X., Harries, P., Wall, C., Al-Mousawi, A., Bonsu, S., Cunha, P., Ward, T., Paul, J., Nadanakumaran, K., Tayeh, S., Holyoak, H., Remedios, J., Theodoropoulou, K., Luhishi, A., Jacob, L., Long, F., Atayi, A., Sarwar, S., Parker, O., Harvey, J., Ross, H., Rampal, R., Thomas, G., Vanmali, P., Mcgowan, C., Stein, J., Robertson, V., Carthew, L., Teng, V., Fong, J., Street, A. N., Thakker, C. E., O'Reilly, D., Bravo, M., Pizzolato, A., Khokhar, H. A., Ryan, M., Cheskes, L., Carr, R., Salih, A. E., Bassiony, S., Yuen, R., Chrastek, D., Rosen O'Sullivan, H., Amajuoyi, A., Wang, A., Sitta, O., Wye, J., Qamar, M. A., Major, C., Kaushal, A., Morgan, C., Petrarca, M., Allot, R., Verma, K., Dutt, S., Chilima, C. P., Peroos, S., Kosasih, S. R., Chin, H., Ashken, L., Pearse, R. J., O'Loughlin, R. A., Menon, A., Singh, K., Norton, J., Sagar, R., Jathanna, N., Rothwell, L., Watson, N., Harding, F., Dube, P., Khalid, H., Punjabi, N., Sagmeister, M., Gill, P., Shahid, S., Hudson-Phillips, S., George, D., Ashwood, J., Lewis, T., Dhar, M., Sangal, P., Rhema, I. A., Kotecha, D., Afzal, Z., Syeed, J. A., Prakash, E., Jalota, P., Herron, J., Kimani, L., Delport, A., Shukla, A., Agarwal, V., Parthiban, S., Thakur, H., Cymes, W., Rinkoff, S., Turnbull, J. A., Hayat, M., Darr, S., Khan, U., Lim, J., Higgins, A., Lakshmipathy, G., Forte, B., Canning, E., Jaitley, A., Lamont, J., Toner, E., Ghaffar, A., Mcdowell, M., Salmon, D., O'Carroll, O., Khan, A., Kelly, M. E., Clesham, K., Palmer, C., Lyons, R., Bell, A., Chin, R., Waldron, R. M., Trimble, A., Cox, S. E., Ashfaq, U., Campbell, J., Holliday, R. B. S., Mccabe, G., Morris, F., Priestland, R., Vernon, O. K., Ledsam, A., Vaughan, R., Lim, D., Bakewell, Z. R., Hughes, R. K., Koshy, R. M., Jackson, H. R., Narayan, P., Cardwell, A. E., Jubainville, C. L., Arif, T., Elliott, L. E., Gupta, V., Bhaskaran, G., Odeleye, A., Ahmed, F., Shah, R., Pickard, J., Suleman, Y. N., North, A. S., Mcclymont, L. F., Hussain, N., Ibrahim, I., Ng, G. S., Wong, V., Lim, A. E., Harris, L. N., Tharmachandirar, T., Mittapalli, D., Patel, V., Lakhani, M., Bazeer, H. Z., Narwani, V., Sandhu, K. K., Wingfield, L. R., Gentry, S., Adjei, H., Bhatti, M., Braganza, L., Barnes, J., Mistry, S., Chillarge, G., Stokes, S., Cleere, J., Bucko, A. M., Meek, J., Boxall, N., Heywood, E. G., Wiltshire, J. J., Toh, C., Ward, A. E., Shurovi, B. N., Horth, D., Patel, B. Y., Ali, B., Spencer, T., Axelson, T., Kretzmer, L., Chhina, C., Anandarajah, C., Fautz, T., Horst, C., Thevathasan, A. A., Ng, J. Q., Hirst, F., Brewer, C. F., Logan, A. E., Lockey, J. W., Forrest, P. R., Keelty, N., Wood, A. D., Springford, L. R., Avery, P., Schulz, T. M., Bemand, T. P., Howells, L., Collier, H., Khajuria, A., Tharakan, R. G., Parsons, S., Buchan, A. M., Mcgalliard, R. J., Mason, J. D., Cundy, O. J., Li, N., Redgrave, N. A., Watson, R. P., Pezas, T. P., Dennis, Y. F., Segall, E., Hameed, M., Lynch, A. S., Chamberlain, M., Peck, F. S., Neo, Y. N., Russell, G., Elseedawy, M., Foster, N. L., Soo, Y. H., Puan, L., Dennis, R., Goradia, H., Qureshi, A., Osman, S., Reeves, T., Dinsmore, L., Marsden, M., Lu, Q., Pitts-Tucker, T., Dunn, C. E., Walford, R. A., Heathcote, E., Martin, R., Pericleous, A., Brzyska, K., Reid, K. G., Williams, M. R., Wetherall, N., Mcaleer, E., Thomas, D., Kiff, R., Milne, S., Holmes, M. J. V., Bartlett, J., Lucas de Carvalho, J., Bloomfield, T., Tongo, F., Bremner, R. H., Yong, N., Atraszkiewicz, B. A., Mehdi, A., Tahir, M., Sherliker, G. X. J., Tear, A. K., Pandey, A., Broyd, A., Omer, H. M., Raphael, M., Chaudhry, W. W., Shahidi, S., Jawad, A. S., Gill, C. K., Hindle Fisher, I., Adeleja, I., Clark, I. J., Aidoo-Micah, G. E., Stather, P. W., Salam, G. J., Glover, T. E., Deas, G., Sim, N. K., Obute, R. D., Wynell-Mayow, W. M., Sait, M. S., Mitha, N., de Bernier, G. L., Siddiqui, M., Shaunak, R., Wali, A., Cuthbert, G., Bhudia, R., Webb, E., Shah, S., Ansari, N., Perera, M., Kelly, N., Mcallister, R., Stanley, G. H., Keane, C. P., Shatkar, V., Maxwell-Armstrong, C., Henderson, L. A., Maple, N., Manson, R., Adams, R. D., Semple, E., Mills, M., Daoub, A., Marsh, A., Ramnarine, A., Hartley, J., Malaj, M., Jewell, P. D., Whatling, E. A., Hitchen, N., Chen, M., Goh, B., Fern, J., Rogers, S., Derbyshire, L., Robertson, D. T., Deekonda, P., Abid, A., Harrison, P. L. M., Aildasani, L., Turley, H., Sherif, M. A., Pandey, G., Filby, J. J., Johnston, A., Burke, E., Mohamud, M., Gohil, K., Tsui, A. Y., Singh, R., Lim, S. J., O'Sullivan, K., Mckelvey, L. L., O'Neill, S., Roberts, H. F., Brown, F. S., Cao, Y., Buckle, R. T., Liew, Y., Sii, S., Ventre, C. M., Graham, C. J., Filipescu, T., Yousif, A., Dawar, R., Wright, A., Peters, M., Varley, R., Owczarek, S., Hartley, S., Khattak, M., Iqbal, A., Ali, M., Durrani, B., Narang, Y., Bethell, G. S., Horne, L., Pinto, R., Nicholls, K., Kisyov, I., Torrance, H. D., English, W., Lakhani, S. M., Ashraf, S. F., Venn, M., Elangovan, V., Kazmi, Z., Brecher, J., Sukumar, S., Mastan, A., Mortimer, A., Parker, J., Boyle, J., Elkawafi, M., Beckett, J., Mohite, A., Narain, A., Mazumdar, E., Sreh, A., Hague, A., Weinberg, D., Fletcher, L., Steel, M., Shufflebotham, H., Masood, M., Sinha, Y., Jenvey, C., Kitt, H., Slade, R., Craig, A. R., Deall, C., Reakes, T., Chervenkoff, J., Strange, E., O'Bryan, M., Murkin, C., Joshi, D., Bergara, T., Naqib, S., Wylam, D., Scotcher, S. E., Hewitt, C. M., Stoddart, M. T., Kerai, A., Trist, A. J., Cole, S. J., Knight, C. L., Stevens, S., Cooper, G. E., Ingham, R., Dobson, J., O'Kane, A., Moradzadeh, J., Duffy, A., Henderson, C., Ashraf, S., Mclaughin, C., Hoskins, T. C., Reehal, R. S., Bookless, L. R., Mclean, R. C., Stone, E. J., Wright, E. V., Abdikadir, H. R., Roberts, C., Spence, O., Srikantharajah, M., Ruiz, E. M., Matthews, J. H., Gardner, E., Hester, E., Naran, P., Simpson, R., Minhas, M., Cornish, E., Semnani, S. A., Rojoa, D., Radotra, A., Eraifej, J., Eparh, K., Smith, D. N. E., Mistry, B. D., Hickling, S. L., Din, W., Liu, C., Mithrakumar, P., Mirdavoudi, V., Rashid, M., Mcgenity, C., Hussain, O., Kadicheeni, M., Gardner, H., Anim-Addo, N., Pearce, J., Aslanyan, A., Ntala, C., Sorah, T., Parkin, J., Alizadeh, M., White, A., Edozie, F., Johnston, J., Kahar, A., Navayogaarajah, V., Carter, D., Khonsari, P., Burgess, A., Patel, B., Kong, C., Ponweera, A., Cody, A., Tan, Y., Ng, A. Y. L., Croall, A., Allan, C., Ng, S., Raghuvir, V., Telfer, R., Greenhalgh, A. D., Mckerr, C. N., Edison, M. A., Patel, B. A., Dear, K., Hardy, M. R., Williams, P., Hassan, S., Sajjad, U., O'Neill, E. M., Lopes, S., Healy, L., Jamal, N., Tan, S., Lazenby, D., Husnoo, S. B., Beecroft, S., Sarvanandan, T., Weston, C., Bassam, N., Rabinthiran, S., Hayat, U., Ng, L., Varma, D., Sukkari, M., Mian, A., Omar, A., Kim, J. W., Sellathurai, J., Mahmood, J., O'Connell, C., Bose, R., Heneghan, H., Lalor, P., Matheson, J., Doherty, C., Cullen, C., Cooper, D., Angelov, S., Drislane, C., Smith, A. C. D., Kreibich, A., Palkhi, E., Durr, A., Lotfallah, A., Gold, D., Mckean, E., Dhanji, A., Anilkumar, A., Thacoor, A., Siddiqui, Z. H., Lim, S., Piquet, A., Anderson, S. M., Mccormack, D. R., Gulati, J., Ibrahim, A., Murray, S. E., Walsh, S. L., Mcgrath, A., Ziprin, P., Chua, E. Y., Lou, C. N., Bloomer, J., Paine, H. R., Osei-Kuffour, D., White, C. J., Szczap, A., Gokani, S., Patel, K., Malys, M. K., Reed, A., Torlot, G. E., Cumber, E. M., Charania, A., Ahmad, S., Varma, N., Cheema, H., Austreng, L., Petra, H., Chaudhary, M., Zegeye, M. I., Cheung, F., Coffey, D., Heer, R. S., Singh, S., Seager, E., Cumming, S., Suresh, R. S., Verma, S., Ptacek, I. B., Gwozdz, A. M., Yang, T., Khetarpal, A. A., Shumon, S., Fung, T. M. P., Leung, W., Kwang, P., Chew, L., Loke, W., Curran, A., Chan, C., Mcgarrigle, C., Mohan, K., Cullen, S., Wong, E., Toale, C., Collins, D., Keane, N., Traynor, B. P., Shanahan, D., Yan, A., Jafree, D. J., Topham, C., Mitrasinovic, S., Omara, S., Bingham, G., Lykoudis, P. M., Miranda, B. H., Whitehurst, K., Kumaran, G., Devabalan, Y., Aziz, H., Shoa, M., Dindyal, S., Yates, J. A., Bernstein, I., Rattan, G., Coulson, R., Stezaker, S., Isaac, A., Salem, M., Mcbride, A., Mcfarlane, H., Yow, L., Macdonald, J., Bartlett, R. D., Turaga, S., White, U., Liew, W., Yim, N., Ang, A., Simpson, A., Mcauley, D., Craig, E., Murphy, L., Shepherd, P., Kee, J. Y., Abdulmajid, A., Chung, A., Warwick, H. L., Livesey, A., Holton, P., Theodoreson, M. D., Jenkin, S. L., Turner, J., Entwisle, J. H., Marchal, S. T., O'Connor, S., Blege, H. K., Aithie, J. M., Sabine, L. M., Stewart, G. E., Jackson, S., Kishore, A., Lankage, C. M., Acquaah, F., Joyce, H. L., Mckevitt, K. L., Coffey, C. J., Fawaz, A. S., Dolbec, K. S., O'Sullivan, D. A., Geraghty, J. M., Lim, E., Bolton, L., Fitzpatrick, D., Robinson, C., Ramtoola, T., Collinson, S., Grundy, L., Mcenhill, P. M., Harbhajan Singh, G. S., Loughran, D., Golding, D. M., Keeling, R. E., Williams, R. P., Whitham, R. D. J., Yoganathan, S., Nachiappan, R., Egan, R. J., Owasil, R., Kwan, M. L., He, A., Goh, R. W., Bhome, R., Wilson, H., Teoh, P. J., Raji, K., Jayakody, N., Matthams, J., Chong, J., Luk, C. Y., Greig, R. J., Trail, M., Charalambous, G., Rocke, A. S., Gardiner, N., Bulley, F., Warren, N., Brennan, E., Fergurson, P., Wilson, R., Whittingham, H., Brown, E. J., Khanijau, R., Gandhi, K., Morris, S., Boulton, A. J., Chandan, N., Barthorpe, A. E., Maamari, R., Sandhu, S., Mccann, M., Higgs, L., Balian, V., Reeder, C., Diaper, C., Sale, T., Ali, H., Archer, C. H., Clarke, A. K., Heskin, J., Hurst, P. C., Farmer, J. D., O'Flynn, L. D., Doan, L., Shuker, B. A., Stott, G. D., Vithanage, N. A., Hoban, K. A., Nesargikar, P. N., Kennedy, H. R., Grossart, C. M., Tan, E. S. M., Roy, C. S. D., Sim, P., Leslie, K. E., Sim, D., Abul, M. H., Cody, N., Tay, A. Y., Woon, E., Sng, S., Mah, J., Robson, J., Shakweh, E., Wing, V. C., Mills, H., Li, M. M., Barrow, T. R., Balaji, S., Jordan, H. E. M., Phillips, C., Naveed, H., Hirani, S., Tai, A., Ratnakumaran, R., Sahathevan, A., Shafi, A. M. A., Seedat, M., Weaver, R., Batho, A., Punj, R., Selvachandran, H., Bhatt, N., Botchey, S., Khonat, Z., Brennan, K., Morrison, C. J., Devlin, E., Linton, A., Galloway, E., Mcgarvie, S., Ramsay, N., Mcrobbie, H. D., Whewell, H., Dean, W., Nelaj, S., Eragat, M., Mishra, A., Kane, T., Zuhair, M., Wells, M., Wilkinson, D., Woodcock, N., Sun, E., Aziz, N., Abd Ghaffar, M. K., Bath, M. F., Nepogodiev, D., and Coco C. (ORCID:0000-0002-4713-7093)
- Abstract
Aim Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a metaanalysis of all available prospective data. Methods This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien–Dindo Grades III–V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results. Results This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery formalignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49–2.96, P < 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk (OR 0.59, 95% CI 0.46–0.75, P < 0.001) compared to normal weight patients. Conclusions In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease.
- Published
- 2018
5. The Eurofever project: an update on the longitudinal stage
- Author
-
Finetti, M, Federici, S, Frenkel, J, Ozen, S, Lachmann, H, De Benedetti, F, Swart, J, Cantarini, L, Gallizzi, R, Cattalini, M, Cimaz, R, Rigante, Donato, Anton, J, Alessio, M, Olivieri, An, Dolezalova, P, Jansson, A, Fabio, G, Sanchez Manubens, J, Hachulla, E, Consolini, R, Krause, K, Ekinci, Z, Brunner, J, Koné-Paut, I, Filocamo, G, Pinedo, Mdc, Papadopoulou-Alataki, E, Bezrodnik, L, Martini, A, Ruperto, N, and Gattorno, M.
- Subjects
Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA ,Hereditary periodic fever - Published
- 2017
6. On closed timelike and spacelike ruled surfaces
- Author
-
Önder, M. and Ekinci, Z. and Manisa Celal Bayar University, Faculty of Arts and Sciences, Department of Mathematics, Manisa, Muradiye, 45140, Turkey
- Abstract
In this study, by using the concepts and results on spherical curves in dual Lorentzian space, we give the criterions for ruled surfaces with non-lightlike ruling to be closed (periodic). Moreover, we obtain the necessary and sufficient conditions to guarantee that a timelike or a spacelike ruled surface is closed (periodic). Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.
- Published
- 2017
7. Comparison of the efficacy of once- and twice-daily colchicine dosage in pediatric patients with familial Mediterranean fever--a randomized controlled noninferiority trial
- Author
-
Ayaz, NA, Polat, A, Kasapcopur, O, Acikel, C, Simsek, D, Dokurel, I, FMF, Arthritis, Kurt, YG, Poyrazoglu, H, Gulez, N, Dursun, İSMAİL, Unsal, E, Ekinci, Z, Bakkaloglu, S, Sozeri, B, Kandur, Y, Peru, H, Demirkaya, E, Delibas, A, Saldir, M, Gok, F, Makay, B, Ozen, S, Polat, SR, Ege Üniversitesi, Selçuk Üniversitesi, and Çocuk Sağlığı ve Hastalıkları
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,education ,Familial Mediterranean fever ,Newly diagnosed ,Dosage schema ,Drug Administration Schedule ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,health services administration ,Medicine ,Colchicine ,Humans ,natural sciences ,Attack frequency ,Child ,030203 arthritis & rheumatology ,Pediatric ,medicine.diagnostic_test ,business.industry ,medicine.disease ,equipment and supplies ,Tubulin Modulators ,Surgery ,Diarrhea ,030104 developmental biology ,chemistry ,Erythrocyte sedimentation rate ,Good clinical practice ,Drug side effects ,Female ,medicine.symptom ,business ,Research Article - Abstract
WOS: 000374731400001, PubMed: 27055417, Background: In this study, we examined the efficacy and safety of a once-daily dosage schema of colchicine compared with a twice-daily dosage schema in pediatric patients with familial Mediterranean fever (FMF). Methods: In this 24-week, multicenter, randomized controlled noninferiority trial, pediatric patients newly diagnosed with FMF carrying a homozygous or compound heterozygous mutation and not receiving any treatment were included. Patients were randomly assigned using a block randomization method to receive treatment with a once-or twice-daily dosage. Clinical and laboratory characteristics and medication side effects were recorded and compared between groups. The study was carried out in compliance with Good Clinical Practice and the Consolidated Standards for Reporting of Trials (CONSORT) statement. Results: A total of 92 patients were selected, and 79 patients completed the study. There were 42 patients in the once-daily dosage group and 37 in the twice-daily dosage group. The results indicated that the once-daily dosage was not inferior to the twice-daily dosage regarding decrease in attack frequency and duration as well as improvement in clinical findings and Mor severity scores. Alterations in laboratory findings indicating inflammation, such as erythrocyte sedimentation rate, C-reactive protein, and serum amyloid A, were similar in both groups. The rates of drug side effects were similar between the once-and twice-daily dosage groups, implying comparable safety of colchicine, with the exception of diarrhea, which was slightly higher in the once-daily dosage group. Conclusions: Using colchicine with either a once-or twice-daily dosage provides similar clinical and laboratory improvements. Considering both efficacy and safety, colchicine can be prescribed with a once-daily dosage., Scientific Council of the Gulhane Military Medical Academy School of Medicine, This study was funded by the Scientific Council of the Gulhane Military Medical Academy School of Medicine and is registered with ClinicalTrials.gov with the number NCT 1491-1437-11/1539 and the identifier NCT02602028.
- Published
- 2016
8. Systemic lupus erythematosus with C1q deficiency: treatment with fresh frozen plasma
- Author
-
Ekinci, Z, primary and Ozturk, K, additional
- Published
- 2017
- Full Text
- View/download PDF
9. The prognostic value of high sensitive C-reactive protein in the early phase of ischemic stroke
- Author
-
Ekinci, Z., primary, Bilgin, R., additional, and Muhtesem, G., additional
- Published
- 2017
- Full Text
- View/download PDF
10. Systemic lupus erythematosus with C1q deficiency: treatment with fresh frozen plasma.
- Author
-
Ekinci, Z. and Ozturk, K.
- Subjects
- *
SYSTEMIC lupus erythematosus treatment , *ARTHRITIS , *THROMBOCYTOPENIA , *METHOTREXATE - Abstract
Treatment and outcome of systemic lupus erythematosus (SLE) in C1q deficient patients are rarely reported. The aim of this report is to share our experience about the course of management of three cases diagnosed as SLE with C1q deficiency, in light of present literature. Initial and dominant complaints of three cases from two different families were cutaneous manifestations. One patient was also diagnosed with arthritis and thrombocytopenia. Antinuclear antibody was positive in all cases, whereas anti-dsDNA was negative with normal levels of complement C3, C4 and decreased CH50 activity. C1QA gene of two patients had homozygous nonsense mutation (c.622 > T/p.Gln208Ter). Previously, all of them had been treated with steroids, hydroxychloroquine and methotrexate or azathioprine. It was learned that they had responded only to high dosage prednisolone and their symptoms flared up during dosage reduction even under methotrexate or azathioprine. All symptoms of all three cases improved by daily fresh frozen plasma (FFP) infusions, and once cutaneous lesions subsided, the infusions were reduced to a frequency that would prevent the flare up of the symptoms. Literature search revealed seven reports on fresh frozen plasma treatment in SLE with C1q deficient patients. In this report, it is concluded that severe cutaneous lesions, as seen in these C1q deficient SLE patients, cannot be controlled with conventional immunosuppressive treatment. Instead, regular fresh frozen plasma infusions are proposed as a more reasonable method of treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
11. FRI0521 Serum Amyloid a in Familial Mediterranean Fever: How Much Important?: Table 1.
- Author
-
Ozturk, K., primary and Ekinci, Z., additional
- Published
- 2015
- Full Text
- View/download PDF
12. AB1031 A Rare Cause of Myopathy: Inflammatory Myopathy with Abundant Macrophages in a Child
- Author
-
Ekinci, Z., primary, Ozturk, K., additional, and Anik, Y., additional
- Published
- 2015
- Full Text
- View/download PDF
13. PReS-FINAL-2195: The comparison of the efficacy of once and twice daily dosage of colchicine in pediatric patients with Familial Mediterranean Fever
- Author
-
Polat, A, primary, Acikel, C, additional, Sozeri, B, additional, Dursun, I, additional, Kasapcopur, O, additional, Peru, H, additional, Dokurel, I, additional, Poyrazoglu, H, additional, Bakkaloglu, S, additional, Delibas, A, additional, Ekinci, Z, additional, Ayaz, NA, additional, Kandur, Y, additional, Unsal, E, additional, Makay, B, additional, Gok, F, additional, Ozen, S, additional, and Demirkaya, E, additional
- Published
- 2013
- Full Text
- View/download PDF
14. Optimisation and modelling of boric acid extraction from colemanite in water saturated with carbon dioxide and sulphur dioxide gases.
- Author
-
Ekinci Z., Ata O.N., Bese A.V., Sayan E., Ekinci Z., Ata O.N., Bese A.V., and Sayan E.
- Abstract
The sequestration and use are discussed of CO2 and SO2 gases for the extraction of boric acid. Fractional factorial and central composite design methods were used to study boric acid extraction at reaction temperatures of 11.4-58.6 degrees C, solid to liquid ratios of 0.0685-0. 1315 g/ml, mean particle sizes of 0.2835-3 mm, stirring speed of 107-893 rpm and reaction times of 7.125-22.875 minutes. A model was developed for the relationship between boric acid extraction efficiency and the process parameters using variance analysis with the Matlab software. Optimum conditions as determined from the model were temperature 41 degrees C, solid to liquid ratio 0.0685 g/ml, mean particle size 0.2835 mm, stirring speed 266 rpm and reaction time 7 minutes. The calculated boric acid extraction efficiency was about 99.9% under optimum conditions., The sequestration and use are discussed of CO2 and SO2 gases for the extraction of boric acid. Fractional factorial and central composite design methods were used to study boric acid extraction at reaction temperatures of 11.4-58.6 degrees C, solid to liquid ratios of 0.0685-0. 1315 g/ml, mean particle sizes of 0.2835-3 mm, stirring speed of 107-893 rpm and reaction times of 7.125-22.875 minutes. A model was developed for the relationship between boric acid extraction efficiency and the process parameters using variance analysis with the Matlab software. Optimum conditions as determined from the model were temperature 41 degrees C, solid to liquid ratio 0.0685 g/ml, mean particle size 0.2835 mm, stirring speed 266 rpm and reaction time 7 minutes. The calculated boric acid extraction efficiency was about 99.9% under optimum conditions.
- Published
- 2007
15. Determination of the Optimum Conditions for Leaching of Malachite Ore in H2SO4 Solutions
- Author
-
Ata, O. N., primary, Çolak, S., additional, Ekinci, Z., additional, and Çopur, M., additional
- Published
- 2001
- Full Text
- View/download PDF
16. Leaching kinetics of sphalerite with pyrite in chlorine saturated water
- Author
-
Ekinci, Z., primary, Colak, S., additional, Cakici, A., additional, and Sarac, H., additional
- Published
- 1998
- Full Text
- View/download PDF
17. Determination of the Optimum Conditions for Leaching of Malachite Ore in H2SO4 Solutions.
- Author
-
Ata, O. N., Çolak, S., Ekinci, Z., and Çopur, M.
- Published
- 2001
- Full Text
- View/download PDF
18. Optimisation of the chlorination of gold in decopperized anode slime in aqueous medium
- Author
-
Donmez, B., Ekinci, Z., Celik, C., and Colak, S.
- Published
- 1999
- Full Text
- View/download PDF
19. Hemolytic uremic syndrome outbreak in Turkey in 2011
- Author
-
Ekinci Z, Candan C, Alpay H, Canpolat N, Sg, Akyüz, Gündüz Z, Dursun I, Bek K, Dursun H, Işıyel E, Öktem F, Tabel Y, İ, Akil, Delibaş A, Kaan Gulleroglu, and Söylemezoğlu O
20. Leaching kinetics of sphalerite with pyrite in chlorine-saturated water.
- Author
-
Ekinci Z., Cakici A., Colak S., Sarac H., Ekinci Z., Cakici A., Colak S., and Sarac H.
- Abstract
Chlorine gas has potential as a leaching agent despite its corrosive nature and difficulty of storage. Direct leaching experiments were carried out on a concentrate from Kozan-Adana, in Turkey, containing 50.21% ZnS and 26.36% FeS2. The leaching rates for both sphalerite and pyrite increased with decreasing particle size, increasing stirring rate, increasing gas flow rate and increasing reaction temperature up to about 25 degrees C; above this temperature, the leaching rate of pyrite decreased with temperature increase up to 70 degrees C. The kinetics and dissolution mechanisms for both zinc and iron were controlled by diffusion throughout the product layer. The activation energy for sphalerite in the ore was calculated as 22.68 kj/mol and the activation energies for pyrite as 43.28 kj/mol in the range 12-20 degrees C and 8.37 kj/mol in the range 30-60 degrees C., Chlorine gas has potential as a leaching agent despite its corrosive nature and difficulty of storage. Direct leaching experiments were carried out on a concentrate from Kozan-Adana, in Turkey, containing 50.21% ZnS and 26.36% FeS2. The leaching rates for both sphalerite and pyrite increased with decreasing particle size, increasing stirring rate, increasing gas flow rate and increasing reaction temperature up to about 25 degrees C; above this temperature, the leaching rate of pyrite decreased with temperature increase up to 70 degrees C. The kinetics and dissolution mechanisms for both zinc and iron were controlled by diffusion throughout the product layer. The activation energy for sphalerite in the ore was calculated as 22.68 kj/mol and the activation energies for pyrite as 43.28 kj/mol in the range 12-20 degrees C and 8.37 kj/mol in the range 30-60 degrees C.
21. Monitoring of Adverse Events and Safety in Autoinflammatory Diseases: Real-Life Data from the Eurofever Registry.
- Author
-
Vyzhga Y, Frenkel J, Insalaco A, Anton J, Koné-Paut I, Legger GE, Fabio G, Cattalini M, Kamphuis S, Hachulla E, Krause K, Ekinci Z, Sanchez-Manubens J, Van den Berg JM, Mora CH, Brinkman D, Labrador E, Potjewijd J, Carlini L, Bustaffa M, Caorsi R, Ruperto N, and Gattorno M
- Subjects
- Humans, Female, Male, Adult, Retrospective Studies, Adolescent, Longitudinal Studies, Young Adult, Middle Aged, Child, Child, Preschool, Aged, Hereditary Autoinflammatory Diseases epidemiology, Infant, Drug-Related Side Effects and Adverse Reactions epidemiology, Europe epidemiology, Adverse Drug Reaction Reporting Systems statistics & numerical data, Registries
- Abstract
Objectives: The study is aimed to evaluate the impact of safety events in the Eurofever registry for Autoinflammatory diseases., Methods: This was a retrospective and longitudinal observational multicentre study. Data were retrieved from the international registry Eurofever, starting patients' enrolment since 2009. All moderate, severe, or very severe AEs reported by treating physician in Eurofever were analyzed regardless of a possible suspected causal relationship to any therapies and according to the latest release of the Medical Dictionary for Regulatory Activities., Results: Complete information on safety were available in 2464 patients enrolled in the registry. In 1499 of them retrospective data encompassing the period from disease onset to enrolment were available, whereas 965 consecutive patients entered in the longitudinal part of the study. A total of 479 AEs have been reported in 275 patients. Eighty-two AEs were reported as serious and 99 were drug-related according to the physicians. Infections or infestations (94; 19.6%), gastrointestinal disorders (66; 13.8%), nervous system disorders (41; 8.6%) and systemic disorders or administration site reactions (35; 7.3%) were the most frequent reported events. The highest absolute number of drug-related AEs were related to biologic DMARDs (40/99 reports, 40,4%) and colchicine (31/99 reports, 31.3%)., Conclusions: Present study shows the importance of a longitudinal and homogeneous registration of the AEs in rare conditions, with a particular focus on the safety profile of the treatments used in these conditions., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2024
- Full Text
- View/download PDF
22. Monogenic lupus due to spondyloenchondrodysplasia with spastic paraparesis and intracranial calcification: case-based review.
- Author
-
Kara B, Ekinci Z, Sahin S, Gungor M, Gunes AS, Ozturk K, Adrovic A, Cefle A, Inanç M, Gul A, and Kasapcopur O
- Subjects
- Adolescent, Adult, Age of Onset, Antirheumatic Agents therapeutic use, Autoimmune Diseases diagnostic imaging, Brain Diseases diagnostic imaging, Calcinosis diagnostic imaging, Female, Humans, Immunologic Deficiency Syndromes diagnostic imaging, Lupus Erythematosus, Systemic drug therapy, Male, Osteochondrodysplasias diagnostic imaging, Siblings, Autoimmune Diseases genetics, Brain Diseases genetics, Calcinosis genetics, Immunologic Deficiency Syndromes genetics, Intellectual Disability genetics, Lupus Erythematosus, Systemic genetics, Osteochondrodysplasias genetics, Paraparesis, Spastic genetics, Tartrate-Resistant Acid Phosphatase genetics
- Abstract
Spondyloenchondrodysplasia (SPENCD) is a rare skeletal dysplasia characterized with platyspondyly and metaphyseal lesions of the long bones mimicking enchondromatosis, resulting in short stature. SPENCD often coexists with neurologic disorders and immune dysregulation. Spasticity, developmental delay and intracranial calcification are main neurologic abnormalities. Large spectrum of immunologic abnormalities may be seen in SPENCD, including immune deficiencies and autoimmune disorders with autoimmune thrombocytopenia and systemic lupus erythematosus as the most common phenotypes. SPENCD is caused by loss of tartrate-resistant acid phosphatase (TRAP) activity, due to homozygous mutations in ACP5, playing a role in non-nucleic acid-related stimulation/regulation of the type I interferon pathway. We present two siblings, 13-year-old girl and 25-year-old boy with SPENCD, from consanguineous parents. Both patients had short stature, platyspondyly, metaphyseal changes, spastic paraparesis, mild intellectual disability, and juvenile-onset SLE. The age at disease-onset was 2 years for girl and 19 years for boy. Both had skin and mucosa involvement. The age at diagnosis of SLE was 4 years for girl, and 19 years for boy. The clinical diagnosis of SPENCD was confirmed by sequencing of ACP5 gene, which revealed a homozygous c.155A > C (p.K52T), a variant reported before as pathogenic. Juvenile-onset SLE accounts for about 15-20% of all SLE cases. But, the onset of SLE before 5-years of age and also monogenic SLE are rare. Our case report and the literature review show the importance of multisystemic evaluation in the diagnosis of SPENCD and to remind the necessity of investigating the monogenic etiology in early-onset and familial SLE cases.
- Published
- 2020
- Full Text
- View/download PDF
23. Outcome of posterior urethral valve in 64 children: a single center's 22-year experience.
- Author
-
Ezel Çelakil M, Ekinci Z, Bozkaya Yücel B, Mutlu N, Günlemez A, and Bek K
- Subjects
- Age of Onset, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Hypertension, Renal etiology, Hypertension, Renal therapy, Infant, Infant, Newborn, Kidney Failure, Chronic etiology, Male, Pregnancy, Prenatal Diagnosis, Proteinuria etiology, Proteinuria therapy, Renal Insufficiency, Chronic etiology, Retrospective Studies, Risk Factors, Treatment Outcome, Urethral Obstruction diagnosis, Urinary Diversion methods, Urologic Surgical Procedures, Vesico-Ureteral Reflux, Urethra abnormalities, Urethra surgery, Urethral Obstruction congenital, Urethral Obstruction surgery
- Abstract
Background: Posterior urethral valve (PUV) is the most serious form of congenital anomalies of kidney and urinary tract (CAKUT) in boys with significant risk of progression to chronic kidney disease (CKD). We present our long-term results in children with PUV., Methods: Retrospective chart review of 113 children with PUV followed within the years of 1996-2018 was performed. Clinical, laboratory and epidemiologic parameters were analyzed for their impact on renal outcome., Results: The median age of diagnosis was 1.00 month (1.00-132.00) and the median follow-up period was 70 months (60.00-216.00). Antenatal diagnosis was present in 33 patients (51.5%) mainly with bilateral hydronephrosis and oligohydramnios. The most common postnatal presentation was recurrent urinary tract infection (UTI) in 14 cases (21.9%) and incontinence in three cases (4.7%). Vesicoureteral-reflux (VUR) was present in 31 cases (48.4%). All patients had surgery and urinary diversion was needed in 18 (28.2%). Varying stages of chronic kidney disease (CKD) developed in 23 cases (35.9%) and rise in serum creatinine was especially prominent after the 4th year of follow-up. Of 23 CKD patients, seven (10.9%) were in ESRD and on dialysis. Mortality occurred in one (1.5%) patient. Hypertension, proteinuria and high initial serum creatinine (>1.28 mg/dL) were statistically significant risk factors for CKD, as expected. Surprisingly VUR and UTI did not show such a significant impact on CKD development. Antenatal detection was with significantly less risk for CKD., Conclusions: Our results confirm that PUV has a considerable risk for CKD development. Antenatal diagnosis, management of proteinuria and hypertension may modify this progression. But already injured kidneys still have a potential risk. The need for further research to evaluate the impact of any intervention on long term renal outcome is obvious.
- Published
- 2019
- Full Text
- View/download PDF
24. Clinical and genetic heterogeneity in familial steroid-sensitive nephrotic syndrome.
- Author
-
Dorval G, Gribouval O, Martinez-Barquero V, Machuca E, Tête MJ, Baudouin V, Benoit S, Chabchoub I, Champion G, Chauveau D, Chehade H, Chouchane C, Cloarec S, Cochat P, Dahan K, Dantal J, Delmas Y, Deschênes G, Dolhem P, Durand D, Ekinci Z, El Karoui K, Fischbach M, Grunfeld JP, Guigonis V, Hachicha M, Hogan J, Hourmant M, Hummel A, Kamar N, Krummel T, Lacombe D, Llanas B, Mesnard L, Mohsin N, Niaudet P, Nivet H, Parvex P, Pietrement C, de Pontual L, Noble CP, Ribes D, Ronco P, Rondeau E, Sallee M, Tsimaratos M, Ulinski T, Salomon R, Antignac C, and Boyer O
- Subjects
- Adolescent, Adult, Child, Child, Preschool, Female, Genetic Heterogeneity, Genetic Predisposition to Disease, Humans, Infant, Male, Middle Aged, Mutation, Nephrotic Syndrome drug therapy, Sequence Analysis, DNA methods, Young Adult, Glucocorticoids therapeutic use, HLA-DQ alpha-Chains genetics, Membrane Glycoproteins genetics, Nephrotic Syndrome genetics
- Abstract
Background: Familial steroid-sensitive nephrotic syndrome (SSNS) is a rare condition. The disease pathophysiology remains elusive. However, bi-allelic mutations in the EMP2 gene were identified, and specific variations in HLA-DQA1 were linked to a high risk of developing the disease., Methods: Clinical data were analyzed in 59 SSNS families. EMP2 gene was sequenced in families with a potential autosomal recessive (AR) inheritance. Exome sequencing was performed in a subset of 13 families with potential AR inheritance. Two variations in HLA-DQA1 were genotyped in the whole cohort., Results: Transmission was compatible with an AR (n = 33) or autosomal dominant (AD, n = 26) inheritance, assuming that familial SSNS is a monogenic trait. Clinical features did not differ between AR and AD groups. All patients, including primary (n = 7) and secondary steroid resistant nephrotic syndrone (SRNS), (n = 13) were sensitive to additional immunosuppressive therapy. Both HLA-DQA1 variations were found to be highly linked to the disease (OR = 4.34 and OR = 4.89; p < 0.001). Exome sequencing did not reveal any pathogenic mutation, neither did EMP2 sequencing., Conclusions: Taken together, these results highlight the clinical and genetic heterogeneity in familial SSNS. Clinical findings sustain an immune origin in all patients, whatever the initial steroid-sensitivity. The absence of a variant shared by two families and the HLA-DQA1 variation enrichments suggest a complex mode of inheritance.
- Published
- 2018
- Full Text
- View/download PDF
25. Refractory idiopathic recurrent pericarditis: treatment with interleukin-1 receptor antagonist is an option!
- Author
-
Ozturk K, Deveci M, and Ekinci Z
- Subjects
- Adolescent, Chest Pain etiology, Humans, Injections, Subcutaneous, Male, Recurrence, Remission Induction, Interleukin 1 Receptor Antagonist Protein administration & dosage, Off-Label Use, Pericarditis drug therapy
- Published
- 2017
- Full Text
- View/download PDF
26. Childhood urinary tract infection caused by extended-spectrum β-lactamase-producing bacteria: Risk factors and empiric therapy.
- Author
-
Uyar Aksu N, Ekinci Z, Dündar D, and Baydemir C
- Subjects
- Case-Control Studies, Child, Child, Preschool, Drug Therapy, Combination, Escherichia coli Infections diagnosis, Escherichia coli Infections drug therapy, Escherichia coli Infections etiology, Female, Humans, Klebsiella Infections diagnosis, Klebsiella Infections drug therapy, Klebsiella Infections etiology, Logistic Models, Male, Microbial Sensitivity Tests, Retrospective Studies, Risk Factors, Urinary Tract Infections diagnosis, Urinary Tract Infections drug therapy, Urinary Tract Infections etiology, Anti-Bacterial Agents therapeutic use, Escherichia coli Infections microbiology, Klebsiella Infections microbiology, Urinary Tract Infections microbiology, beta-Lactam Resistance
- Abstract
Background: This study investigated risk factors of childhood urinary tract infection (UTI) associated with extended-spectrum β-lactamase (ESBL)-producing bacteria (ESBL-positive UTI) and evaluated antimicrobial resistance as well as empiric treatment of childhood UTI., Methods: The records of children with positive urine culture between 1 January 2008 and 31 December 2012 were evaluated. Patients with positive urine culture for ESBL-producing bacteria were defined as the ESBL-positive group, whereas patients of the same gender and similar age with positive urine culture for non-ESBL-producing bacteria were defined as the ESBL-negative group. Each ESBL-positive patient was matched with two ESBL-negative patients., Results: The ESBL-positive and negative groups consisted of 154 and 308 patients, respectively. Potential risk factors for ESBL-positive UTI were identified as presence of underlying disease, clean intermittent catheterization (CIC), hospitalization, use of any antibiotic and history of infection in the last 3 months (P < 0.05). On logistic regression analysis, CIC, hospitalization and history of infection in the last 3 months were identified as independent risk factors. In the present study, 324 of 462 patients had empiric therapy. Empiric therapy was inappropriate in 90.3% of the ESBL-positive group and in 4.5% of the ESBL-negative group. Resistance to nitrofurantoin was similar between groups (5.1% vs 1.2%, P = 0.072); resistance to amikacin was low in the ESBL-positive group (2.6%) and there was no resistance in the ESBL-negative group., Conclusions: Clean intermittent catheterization, hospitalization and history of infection in the last 3 months should be considered as risk factors for ESBL-positive UTI. The combination of ampicillin plus amikacin should be taken into consideration for empiric therapy in patients with acute pyelonephritis who have the risk factors for ESBL-positive UTI. Nitrofurantoin seems to be a logical choice for the empiric therapy of cystitis., (© 2016 Japan Pediatric Society.)
- Published
- 2017
- Full Text
- View/download PDF
27. Is neutrophil-to-lymphocyte ratio valid to predict organ involvement in Henoch-Schönlein purpura?
- Author
-
Ozturk K and Ekinci Z
- Subjects
- Humans, Lymphocytes, IgA Vasculitis, Neutrophils
- Published
- 2016
- Full Text
- View/download PDF
28. Comparison of the efficacy of once- and twice-daily colchicine dosage in pediatric patients with familial Mediterranean fever--a randomized controlled noninferiority trial.
- Author
-
Polat A, Acikel C, Sozeri B, Dursun I, Kasapcopur O, Gulez N, Simsek D, Saldir M, Dokurel I, Poyrazoglu H, Bakkaloglu S, Delibas A, Ekinci Z, Ayaz NA, Kandur Y, Peru H, Kurt YG, Polat SR, Unsal E, Makay B, Gok F, Ozen S, and Demirkaya E
- Subjects
- Child, Drug Administration Schedule, Female, Humans, Male, Colchicine administration & dosage, Familial Mediterranean Fever drug therapy, Tubulin Modulators administration & dosage
- Abstract
Background: In this study, we examined the efficacy and safety of a once-daily dosage schema of colchicine compared with a twice-daily dosage schema in pediatric patients with familial Mediterranean fever (FMF)., Methods: In this 24-week, multicenter, randomized controlled noninferiority trial, pediatric patients newly diagnosed with FMF carrying a homozygous or compound heterozygous mutation and not receiving any treatment were included. Patients were randomly assigned using a block randomization method to receive treatment with a once- or twice-daily dosage. Clinical and laboratory characteristics and medication side effects were recorded and compared between groups. The study was carried out in compliance with Good Clinical Practice and the Consolidated Standards for Reporting of Trials (CONSORT) statement., Results: A total of 92 patients were selected, and 79 patients completed the study. There were 42 patients in the once-daily dosage group and 37 in the twice-daily dosage group. The results indicated that the once-daily dosage was not inferior to the twice-daily dosage regarding decrease in attack frequency and duration as well as improvement in clinical findings and Mor severity scores. Alterations in laboratory findings indicating inflammation, such as erythrocyte sedimentation rate, C-reactive protein, and serum amyloid A, were similar in both groups. The rates of drug side effects were similar between the once- and twice-daily dosage groups, implying comparable safety of colchicine, with the exception of diarrhea, which was slightly higher in the once-daily dosage group., Conclusions: Using colchicine with either a once- or twice-daily dosage provides similar clinical and laboratory improvements. Considering both efficacy and safety, colchicine can be prescribed with a once-daily dosage., Trial Registration Id: ClinicalTrials.gov identifier NCT02602028 . Registered 5 November 2015.
- Published
- 2016
- Full Text
- View/download PDF
29. Effect of cholecalciferol on local arterial stiffness and endothelial dysfunction in children with chronic kidney disease.
- Author
-
Aytaç MB, Deveci M, Bek K, Kayabey Ö, and Ekinci Z
- Subjects
- Administration, Oral, Adolescent, Biomarkers, Calcifediol blood, Child, Child, Preschool, Echocardiography, Female, Humans, Male, Renal Insufficiency, Chronic physiopathology, Vitamin D Deficiency complications, Young Adult, Cholecalciferol therapeutic use, Endothelium, Vascular drug effects, Renal Insufficiency, Chronic drug therapy, Vascular Stiffness drug effects, Vitamin D Deficiency drug therapy, Vitamins therapeutic use
- Abstract
Background: As cardiovascular factors are the leading cause of mortality in chronic kidney disease (CKD) and as vitamin D deficiency is prevalent in this population, we aimed to examine the effect of oral cholecalciferol on cardiac parameters and biomarkers for endothelial cell activation in children with CKD., Methods: Forty-one children with CKD and 24 healthy subjects free of any underlying cardiac or renal disease with low 25-hydroxyvitamin D3 (25OHD) levels were evaluated using echocardiography basally and following Stoss vitamin D supplementation. The local vascular stiffness and endothelial dysfunction markers were compared among the groups., Results: Initial flow-mediated dilatation (FMD) measurements were lower and local arterial stiffness was significantly higher in patients. After vitamin D supplementation, these improved significantly in patients, while no significant change was observed for the healthy group. Homocysteine showed inverse correlation with baseline vitamin D level in CKD children and von Willebrand factor emerged as an independent risk factor for FMD impairment., Conclusions: Our interventional study revealed the favorable effects of high-dose cholecalciferol on cardiovascular and endothelial parameters, implying the importance of vitamin D supplementation in children with CKD.
- Published
- 2016
- Full Text
- View/download PDF
30. Successful treatment of macrophage activation syndrome due to systemic onset juvenile idiopathic arthritis with antithymocyte globulin.
- Author
-
Ozturk K and Ekinci Z
- Subjects
- Child, Female, Humans, Macrophage Activation Syndrome etiology, Treatment Outcome, Antilymphocyte Serum therapeutic use, Arthritis, Juvenile complications, Macrophage Activation Syndrome drug therapy
- Published
- 2015
- Full Text
- View/download PDF
31. Early bone marrow failure in a 6-year-old boy with cystinosis.
- Author
-
Demirsoy U and Ekinci Z
- Subjects
- Anemia diagnosis, Anemia etiology, Bone Marrow Diseases diagnosis, Bone Marrow Examination, Child, Cystinosis diagnosis, Fatal Outcome, Humans, Kidney Failure, Chronic diagnosis, Kidney Failure, Chronic etiology, Male, Thrombocytopenia diagnosis, Thrombocytopenia etiology, Bone Marrow Diseases etiology, Cystinosis complications
- Published
- 2015
- Full Text
- View/download PDF
32. Loss-of-function mutations in WDR73 are responsible for microcephaly and steroid-resistant nephrotic syndrome: Galloway-Mowat syndrome.
- Author
-
Colin E, Huynh Cong E, Mollet G, Guichet A, Gribouval O, Arrondel C, Boyer O, Daniel L, Gubler MC, Ekinci Z, Tsimaratos M, Chabrol B, Boddaert N, Verloes A, Chevrollier A, Gueguen N, Desquiret-Dumas V, Ferré M, Procaccio V, Richard L, Funalot B, Moncla A, Bonneau D, and Antignac C
- Subjects
- Adolescent, Brain physiopathology, Cell Line, Cell Survival, Child, Child, Preschool, Cytosol metabolism, Exome genetics, Hernia, Hiatal physiopathology, Homozygote, Humans, Kidney Glomerulus physiopathology, Male, Microcephaly physiopathology, Microtubules metabolism, Mitosis, Models, Molecular, Mutation, Nephrosis physiopathology, Nephrotic Syndrome physiopathology, Podocytes, Protein Transport, Proteins metabolism, Spindle Poles metabolism, Hernia, Hiatal genetics, Intellectual Disability genetics, Microcephaly genetics, Nephrosis genetics, Nephrotic Syndrome genetics, Proteins genetics
- Abstract
Galloway-Mowat syndrome is a rare autosomal-recessive condition characterized by nephrotic syndrome associated with microcephaly and neurological impairment. Through a combination of autozygosity mapping and whole-exome sequencing, we identified WDR73 as a gene in which mutations cause Galloway-Mowat syndrome in two unrelated families. WDR73 encodes a WD40-repeat-containing protein of unknown function. Here, we show that WDR73 was present in the brain and kidney and was located diffusely in the cytoplasm during interphase but relocalized to spindle poles and astral microtubules during mitosis. Fibroblasts from one affected child and WDR73-depleted podocytes displayed abnormal nuclear morphology, low cell viability, and alterations of the microtubule network. These data suggest that WDR73 plays a crucial role in the maintenance of cell architecture and cell survival. Altogether, WDR73 mutations cause Galloway-Mowat syndrome in a particular subset of individuals presenting with late-onset nephrotic syndrome, postnatal microcephaly, severe intellectual disability, and homogenous brain MRI features. WDR73 is another example of a gene involved in a disease affecting both the kidney glomerulus and the CNS., (Copyright © 2014 The American Society of Human Genetics. Published by Elsevier Inc. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
33. A case of Liddle syndrome: correspondence.
- Author
-
Ekinci Z
- Subjects
- Humans, Male, Liddle Syndrome diagnosis
- Published
- 2014
- Full Text
- View/download PDF
34. Hemolytic uremic syndrome outbreak in Turkey in 2011 - Reply.
- Author
-
Ekinci Z and Söylemezoğlu O
- Subjects
- Female, Humans, Male, Diarrhea complications, Disease Outbreaks, Escherichia coli isolation & purification, Escherichia coli Infections complications, Hemolytic-Uremic Syndrome epidemiology
- Published
- 2013
35. A case of SCNN1A splicing mutation presenting as mild systemic pseudohypoaldosteronism type 1.
- Author
-
Ekinci Z, Aytac MB, and Cheong HI
- Subjects
- Female, Humans, Infant, Newborn, Pseudohypoaldosteronism physiopathology, Epithelial Sodium Channels genetics, Mutation, Pseudohypoaldosteronism genetics, RNA Splicing
- Abstract
Systemic pseudohypoaldosteronism type 1 (PHA1) is characterized by excessive salt loss from the renal tubulus, colon, sweat and salivary glands. Here we present a case of systemic PHA1 whose genetic analysis revealed a homozygous splicing mutation in intron 4 of SCNN1A (c.684+2 T>A) and discuss with the patient's phenotype. Previously described systemic PHA cases show varying degrees of severity dependent on the mutation. Most of the SCNN1A gene mutations present with a severe phenotype. The long-term follow-up and phenotype of the two reported cases with splicing mutation of the SCNN1A gene are unknown. Our case, with a new splicing mutation of SCNN1A, presented with a severe phenotype in the neonatal period. Since then she has been well without any hospitalization and respiratory illness. Her requirement for medication also decreased gradually. After early infancy she presented a mild systemic PHA1 phenotype up to the age of 39 months. In conclusion, the mutation in the patient is located at the splicing site and is definitely a new and pathogenic one, and the phenotype of the patient was milder as observed in a patient with missense mutation.
- Published
- 2013
- Full Text
- View/download PDF
36. Hypomagnesemia-hypercalciuria-nephrocalcinosis and ocular findings: a new claudin-19 mutation.
- Author
-
Ekinci Z, Karabaş L, and Konrad M
- Subjects
- Child, Consanguinity, Female, Homozygote, Humans, Myopia genetics, Nystagmus, Pathologic genetics, Retinitis Pigmentosa genetics, Claudins genetics, Codon, Nonsense, Hypercalciuria genetics, Magnesium Deficiency genetics, Nephrocalcinosis genetics
- Abstract
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is an autosomal recessive syndrome that affects the tight junction proteins claudin-16 and claudin-19 in the thick ascending limb. In patients with claudin-19 mutations, additional symptoms such as visual impairment and other ophthalmologic findings are expected. In this report, we present a seven-year-old girl with polyuria and polydipsia. She was the daughter of consanguineous parents with a history of neonatal hypomagnesemic convulsion. On physical examination, bilateral horizontal nystagmus, retinitis pigmentosa and severe myopia were detected. Laboratory examination revealed hypomagnesemia, hypercalciuria and hypermagnesuria. A clinical diagnosis of FHHNC caused possibly by claudin-19 mutation was decided with the ocular findings. DNA analysis revealed a novel homozygous nonsense mutation (W169X) in the CLDN19 gene. In conclusion, in a patient with consanguineous parents, history of hypomagnesemic convulsion and disturbed organization and development of the retina, a diagnosis of FHHNC caused by claudin-19 mutation should be considered.
- Published
- 2012
37. Urinary tract infection prophylaxis in children with neurogenic bladder with cranberry capsules: randomized controlled trial.
- Author
-
Mutlu H and Ekinci Z
- Abstract
Objectives. The aim of this randomized controlled prospective study is to evaluate the efficacy of cranberry capsules for prevention of UTI in children with neurogenic bladder caused by myelomeningocele. Patients and Methods. To be eligible for this study, patients had to be diagnosed as neurogenic bladder caused by myelomeningocele, evaluated urodynamically, followed up with clean intermittent catheterization and anticholinergic drugs. Intervention. Six months of treatment with placebo; after a week of wash-out period treatment of cranberry extract tablets (1 capsule/day) for an additional 6 months. Randomization was performed sequentially. Patients and care givers were blinded to drug assignment. Main outcome measure was infection rate. Group comparisons were performed with Wilcoxon test. Results. The study population included 20 (F/M: 13/7) patients with neurogenic bladder with the mean age of 7.25 ± 3.49 (4, 18) years. The median UTI rate was 0.5/year during placebo usage whereas 0/year during cranberry capsule usage. Decrease in infection rate was significant with cranberry capsule usage (P = 0.012). Decrease in the percentage of the pyuria was also recorded as significant (P = 0.000). Any adverse events or side effects were not recorded. Conclusion. We concluded that cranberry capsules could be an encouraging option for the prevention of recurrent UTI in children with neurogenic bladder caused by myelomeningocele.
- Published
- 2012
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.