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1. Cannabis sativa L. essential oil: Chemical composition, anti-oxidant, anti-microbial properties, and acute toxicity: In vitro, in vivo, and in silico study

Author

El-Mernissi Rafik, El Menyiy Naoual, Moubachir Rania, Zouhri Aziz, El-Mernissi Yahya, Siddique Farhan, Nadeem Sumaira, Ibork Hind, El Barnossi Azeddin, Wondmie Gezahign Fentahun, Bourhia Mohammed, Bin Jardan Yousef A., Abboussi Oualid, and Hajji Lhoussain

Subjects
antimicrobial, antioxidant, cannabis sativa l., essential oils, gc-ms, toxicity, Chemistry, QD1-999
Abstract

This study evaluated the volatile components of Cannabis sativa L. essential oils (CSEOs) and their pharmacological potential in vitro, in animal, and in silico. The anti-oxidant capacities of volatile compounds were tested using 2,2-diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), total anti-oxidant capacity (TAC), and gas chromatography-mass spectrometry (GC-MS). Anti-microbial activity against bacterial and fungal strains was assessed using disk diffusion and micro-dilution, and acute toxicity was examined on mice using OECD 423 criteria. The results indicate that the main components were β-caryophyllene (31.54%), α-humulene (12.62%), β-myrcene (4.83%), and α-pinene (4.69%). The essential oil showed high anti-oxidant ability (IC50 = 0.981 ± 0.059 mg/ml for DPPH, EC50 = 1.74 ± 0.05 for FRAP), and TAC of 0.101 ± 0.001 mg AAE/g. Additionally, it showed significant antibacterial action against Gram-negative organisms, such as Escherichia coli (11.33 ± 0.00 mm), Klebsiella pneumonia (9 ± 0.00 mm), and Pseudomonas aeruginosa (9.34 ± 0.00), with MICs ranging from 0.0052 to 0.0208 mg/CSEO demonstrated antifungal activity against Candida albicans and Fusarium proliferatum, with activity levels of 18.66 ± 0.88 mm, 41.89 ± 3.60%, and MICs of 0.39 and 0.013 mg/ml, respectively. In toxicological studies, CSEO proved to be safe for animals. Docking identified bioactive components and explored anti-oxidant and antibacterial properties. Docking proved that bulnesol and champacol caused indicated actions.

Published
2024
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2. List of contributors

Author

Abalo, Raquel, primary, Abdelghffar, Eman A., additional, Abdelkhalek, Yasmin M., additional, Acuña, Sabrina, additional, Adeyemo, Oluwatobi, additional, Ahlawat, Jyoti, additional, Ahmad, Aftab, additional, Ahsan, Khansa, additional, Ajeigbe, Olufunke Florence, additional, Alberto-Silva, Carlos, additional, Ali, Javed, additional, Almeida, Carlos Gabriel Moreira, additional, Almeida, Áurea Maria Alves Nunes, additional, Alves, Anna Beatriz Pereira Simões, additional, Anamelechi, Joy, additional, Andreatini, R., additional, Arbo, Bruno Dutra, additional, Arent, Camila O., additional, Ashraf, Hagar, additional, Aslim, Belma, additional, Atarase, Oyepeju, additional, Awasthi, Rajendra, additional, Baboota, Sanjula, additional, Bagatini, Margarete Dulce, additional, Bakrim, Saad, additional, Barajas-Saucedo, C.E., additional, Bassols, Anna, additional, Batagin-Neto, Augusto, additional, Benameur, Tarek, additional, Bermúdez-Guzmán, M.J., additional, Bernardi, María Alejandra, additional, Bertollo, Amanda Gollo, additional, Beulaja, M., additional, Bhattacharya, Pallab, additional, Binda, Nancy Scardua, additional, Bisagno, Verónica, additional, Boeira, Silvana Peterini, additional, Bonjorno, Andressa Francielli, additional, Borah, Anupom, additional, Borsini, Alessandra, additional, Botelho, Maria Eduarda M., additional, Boudreau, Luc H., additional, Bouyahya, Abdelhakim, additional, Brimson, James Michael, additional, Bujtor, Melissa, additional, Büsselberg, Dietrich, additional, Butt, Arthur Morgan, additional, Čagalj, Martina, additional, Candeias, Emanuel, additional, Cardoso, Sandra Morais, additional, Carlini, Celia R., additional, Carrazoni, Thiago, additional, Carreira, Rodrigo Barreto, additional, Carrera-González, María Pilar, additional, Castro e Silva, Juliana Helena, additional, Catherene, M. Livya, additional, Chamorro, María E., additional, Charlotte, Lechevallier, additional, Chaudhary, Antra, additional, Chiba, Diego Eidy, additional, Choonara, Yahya E., additional, Chukwudozie, Kingsley Ikechukwu, additional, Convertini, Paolo, additional, Correa, Florencia, additional, Costa, Silvia Lima, additional, Cox, Paul Alan, additional, Crispi, Stefania, additional, Cuciniello, Rossana, additional, urko-Cofek, Božena, additional, da Cunha, Israel Cordeiro Eller, additional, da Rocha Fernandes, Livia, additional, da Silva, Gilnei Bruno, additional, da Silva, Juliana Figueira, additional, da Silva, Victor Diogenes Amaral, additional, Dakka, Nadia, additional, Dal Belo, Cháriston André, additional, Datta, Aishika, additional, de Almeida, Monique Marylin Alves, additional, de Araújo, Fillipe Mendes, additional, de Bari, Lidia, additional, de Faria Lopes, Giselle Pinto, additional, de Gomes, Marcelo Gomes, additional, de Oliveira, Juciele Valéria Ribeiro, additional, de Oliveira, Marcos Roberto, additional, de Oliveira, Êndel Alves Gomes, additional, de Sampaio Schitine, Clarissa, additional, de Souza, Suzana Braga, additional, de Souza, Veronica Moreira, additional, Del Fabbro, Lucian, additional, Dhiman, Neerupma, additional, Di Meo, Francesco, additional, Dias Costa, Maria de Fatima, additional, do Nascimento, Ravena Pereira, additional, Dora, Cristiana Lima, additional, dos Santos, Balbino Lino, additional, dos Santos, Cleonice Creusa, additional, dos Santos, Jean Leandro, additional, dos Santos, Michele Goulart, additional, Dourado, Naiara Silva, additional, El Idrissi, Abdeslem, additional, El Menyiy, Naoual, additional, Eldahshan, Omayma A., additional, El-Nashar, Heba A.S., additional, El-Shazly, Mohamed, additional, Empadinhas, Nuno, additional, Esteban, S., additional, Esteves, A. Raquel, additional, Ezenandu, Emmanuel Obinna, additional, Ezeorba, Timothy Prince Chidike, additional, Ezeudoka, Brendan Chukwuemeka, additional, Fagiolino, Pietro, additional, Farombi, Ebenezer O., additional, Ferreira, Rafael Short, additional, Finnie, John W., additional, Furian, Ana Flávia, additional, Gaitán-Hinojosa, M.A., additional, Galván-Hernández, A.R., additional, García-Villalvazo, P.E., additional, Garg, Chahat, additional, Gazerani, Parisa, additional, Ghosh, Bijoyani, additional, Gomez, Marcus Vinícius, additional, González-Bulnes, Antonio, additional, Goyal, Lav, additional, Grewal, Amarjot Kaur, additional, Grubi Kezele, Tanja, additional, Guedes, Beatriz, additional, Guevara, Natalia, additional, Gutierrez, Antonia, additional, Habtemariam, Solomon, additional, Haghdoost-Yazdi, Hashem, additional, Hassoun, Abdo, additional, Heidari, Reza, additional, Hernández-González, Ignacio, additional, Horn, Ana Paula, additional, Hort, Mariana Appel, additional, Hritcu, Lucian, additional, Hyslop, Stephen, additional, Ibarra-Vega, R., additional, Ignácio, Zuleide Maria, additional, Ikeji, Cynthia Nwamaka, additional, Infantino, Vittoria, additional, James, Adewale Segun, additional, Jauquet, Mélissa, additional, Jimenez-García, M., additional, Jiménez-Vargas, J.M., additional, Junge, Stephanie, additional, Kalapos, Miklós Péter, additional, Kalra, Palak, additional, Kanazawa, L.K.S., additional, Kanekar, Shami, additional, Kargieman, Lucila, additional, Kaur, Jasleen, additional, Kaushik, Medha, additional, Kaushik, Pooja, additional, Khan, Farha Deeba, additional, Kharkwal, Harsha, additional, Komane, Patrick P., additional, Kubatka, Peter, additional, Kulkarni, G.T., additional, Kumar, Pradeep, additional, Kumar, Shobhit, additional, la Torre, Maria Ester, additional, Lahyaoui, Manal, additional, Lefebvre, Kathi A., additional, Leite, José Roberto S.A., additional, Lemarchand, Eloïse, additional, Lino-López, G.J., additional, Lopes, Flávia Garcia, additional, Lopes, Juliana Romano, additional, Lopez del Castillo, Ines, additional, López-Gómez, Laura, additional, Loureiro, Joana, additional, Luhach, Kanishk, additional, Magalhães, João Duarte, additional, Mahalakshmi, K., additional, Malar, Dicson Sheeja, additional, Maldonado, Cecilia, additional, Maltaneri, Romina E., additional, Manikandan, R., additional, Manosso, Luana M., additional, Marciniak, Stefan J., additional, Marín-Prida, Javier, additional, Marques, Magno da Silva, additional, Martínez-Martos, José Manuel, additional, Martyniuk, Christopher J., additional, Matosinhos, Rafaela Cunha, additional, Maurya, Shashank Kumar, additional, Melo-Marques, Inês, additional, Messina, Antonietta, additional, Messina, Giovanni, additional, Metcalf, James S., additional, Mihaiela, Cornea-Cipcigan, additional, Miralles, A., additional, Mishra, Rajeev, additional, Mishra, Rajnikant, additional, Monda, Marcellino, additional, Monda, Vincenzo, additional, Moranta, D., additional, Moreira, Daniel C., additional, Moreno-Gonzalez, Ines, additional, Morin, Pier, additional, Munawar, Nayla, additional, Naqvi, Saba, additional, Nedel, Cláudia Beatriz, additional, Nelissen, E., additional, Nesse, Alcira B., additional, Nigdelioglu Dolanbay, Serap, additional, Nunes-Costa, Daniela, additional, Ojo, Mercy Olubunmi, additional, Okeke, Emmanuel Sunday, additional, Okoye, Charles Obinwanne, additional, Okoye, Henrietta Ukamaka, additional, Oliveira, R.M.W., additional, Oliveira, Raquel Soares, additional, Ommati, Mohammad Mehdi, additional, Onaolapo, Adejoke Y., additional, Onaolapo, Olakunle J., additional, Panaro, Maria Antonietta, additional, Pappalardo, Ilaria, additional, Parimalanandhini, D., additional, Parvez, Suhel, additional, Patel, Mayank, additional, Pavan, Aline Renata, additional, Pedro, Lucas C., additional, Pentón-Rol, Giselle, additional, Pereira, Erica Patrícia, additional, Pereira-Santos, A. Raquel, additional, Pérez-Valle, Jorge, additional, Perissinotti, Paula P., additional, Phadke, Girija Gajanan, additional, Piermartiri, Tetsade C.B., additional, Pinto, João Victor Krüger, additional, Pizzolorusso, Ilaria, additional, Polito, Rita, additional, Porro, Chiara, additional, Portaro, Fernanda Calheta Vieira, additional, Prasad, K.V.S.R.G., additional, Prasanth, Mani Iyer, additional, Prickaerts, J., additional, Prokai, Laszlo, additional, Prokai-Tatrai, Katalin, additional, Quevedo, João, additional, Rabbani, Syed Arman, additional, Raj, Khadga, additional, Ramírez-Expósito, María Jesús, additional, Ramis, M.R., additional, Rana, Nikita, additional, Rathod, Nikheel Bhojraj, additional, Rawat, Kajal, additional, Retana-Marquez, Socorro, additional, Réus, Gislaine Z., additional, Ribeiro, Paulo Roberto, additional, Ríos-Bracamontes, E.F., additional, Rivero-Echeto, María Celeste S., additional, Rodica, Mrgoan, additional, Rodríguez-Leone, Nazarena, additional, Roussel, Benoit D., additional, Ruggiero, Melania, additional, Rupasree, P., additional, Saha, Lekha, additional, Salau, Veronica F., additional, Sangeetha, R., additional, Sardana, Satish, additional, Sarduy-Chávez, Rocío de la Caridad, additional, Sarmah, Deepaneeta, additional, Sarubbo, F., additional, Schimith, Lucia Emanueli, additional, Shahidul Islam, Md., additional, Sharika, Rajasekharan, additional, Sharma, Bhupesh, additional, Sharma, Poonam, additional, Sharma, Shrestha, additional, Shrivastava, Rahul, additional, Siddique, Yasir Hasan, additional, Silva, Marilyn H., additional, Šimat, Vida, additional, Singh, Gyanendra, additional, Singh, Neha, additional, Singh, Shamsher, additional, Singh, Thakur Gurjeet, additional, Singh, Varinder, additional, Sirin, Seda, additional, Soares, Janaina Ribeiro Pereira, additional, Souza, Cleide dos Santos, additional, Souza, Nara, additional, Srivastava, Vikas, additional, Su, Kuan-Pin, additional, Sujatha, D., additional, Sukach, Volodymyr, additional, Sunitha, S., additional, Tabassum, Heena, additional, Tasca, Carla I., additional, Tasker, R. Andrew, additional, Tasleem, Ammar, additional, Tejada, S., additional, Tencomnao, Tewin, additional, Torres, Rosimere Oliveira, additional, Triniac, Hortense, additional, Tripathi, Swapnil, additional, Trotta, Teresa, additional, Ugbaja, Regina Ngozi, additional, Ugbaja, Victory Chukwudalu, additional, Ugwor, Emmanuel Ifeanyichukwu, additional, Urbano, Francisco J., additional, Uzal, Francisco A., additional, Valdez-Velazquez, L.L., additional, Vaz, Gustavo Richter, additional, Vázquez, Marta, additional, Vegas-Gomez, Laura, additional, Victor, Mauricio Moraes, additional, Villalba, Sofia, additional, Villano, Ines, additional, Vinadé, Lucia, additional, Vital, M.A.B.F., additional, Vittori, Daniela C., additional, Vivien, Denis, additional, Yachou, Yassine, additional, Yeste, Natalia, additional, Zaman, Khadiza, additional, Zavalza-Gálvez, D.I., additional, Zeb, Alam, additional, and Zhai, Kevin, additional

Published
2024
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5. Mineral composition, principal polyphenolic components, and evaluation of the anti-inflammatory, analgesic, and antioxidant properties of Cytisus villosus Pourr leaf extracts

Author

Zouhri Aziz, El Menyiy Naoual, El-mernissi Yahya, Bouddine Toufik, El-mernissi Rafik, Amhamdi Hassan, Elharrak Abdelhay, Salamatullah Ahmad Mohammad, Nafidi Hiba-Allah, Khallouki Farid, Bourhia Mohammed, and Hajji Lhoussain

Subjects
antioxidant activity, anti-inflammatory, analgesic activity, cytisus villosus, uplc-esi-ms/ms, Chemistry, QD1-999
Abstract

Cytisus villosus Pourr. (C. villosus) is a medicinal plant belonging to the Fabaceae family, which grows in the Mediterranean area. It is used in traditional medicine against diseases related to inflammation. The objective of the present study was to identify the mineral and polyphenolic composition as well as to evaluate some biological properties including antioxidant, anti-inflammatory, and analgesic activities of C. villosus leaf aqueous extract. The chemical constituents were identified and quantified using ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS) methods. The antioxidant properties of C. villosus leaves were tested using reducing power (RP), 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), and 2,2′-diphenyl-1-picrylhydrazyl (DPPH) assays. The anti-inflammatory potency was evaluated in vitro and in vivo using the albumin denaturation test and the carrageenan test, respectively. Furthermore, the analgesic effect was performed in vivo using tail flick, acetic acid-induced contortion, and plantar tests. Mineralogical analysis revealed that potassium and calcium were the most abundant minerals. The analysis and quantification of the phytochemical composition using UPLC-ESI-MS/MS showed that quinic acid (57.478 ± 1.72 mg/kg) was the major compound of the aqueous extract, followed by salicylic acid (17.38 ± 0.2 mg/kg), isoquercetin (16.895 ± 1.01 mg/kg), and gallic acid (15.914 ± 1.51 mg/kg). The extracts showed potent antioxidant activity for all tests used. The highest antioxidant activity was recorded for the DPPH, ABTS and RP methods, with an IC50 of 3.94 ± 0.09, 2.88 ± 0.07, and 1.94 ± 0.10 μg/mL, respectively. Additionally, using the most frequent analgesic assays, the aqueous extract at a dose of 500 mg/kg exhibited a potent analgesic activity. Notably, an interesting inhibition of albumin denaturation was recorded with an IC50 of 383.94 μg/mL, corroborating the in vivo test. Overall, the results presented here may represent a scientific basis for the traditional use of C. villosus in the treatment of inflammation-related diseases.

Published
2023
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9. Anti-Quorum Sensing Agents from Natural Sources

Author

Bouyahya, Abdelhakim, El Omari, Nasreddine, El Menyiy, Naoual, Guaouguaou, Fatima-Ezzahrae, Balahbib, Abdelaali, Chamkhi, Imane, Kumar, Vinay, editor, Shriram, Varsha, editor, Paul, Atish, editor, and Thakur, Mansee, editor

Published
2022
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10. Ethnobotanical survey of medicinal plants used in cosmetics in Ketama (North of Morocco)

Author

El-Mernissi Yahya, Zouhri Aziz, Labhar Amina, El-Mernissi Rafik, El menyiy Naoual, Ahari M’hamed, El Barkany Soufian, Salhi Amin, Hajji Lhoussain, and Amhamdi Hassan

Subjects
Environmental sciences, GE1-350
Abstract

Medicinal plants serve as a significant source of bioactive molecules, with their utilization in the medical realm dating back to ancient times through herbal preparations. In Morocco, the utilization of plants remains integral to traditional medicine. Despite numerous studies documenting indigenous knowledge regarding plant use, scant attention has been given to northern Morocco, particularly the Rif region. This study seeks to enrich and consolidate our understanding of plant utilization in this area. The ethnobotanical investigation was centred on medicinal plants employed in cosmetics within northern Morocco. A questionnaire was disseminated, gathering data encompassing plant names, utilized plant parts, and preparation methods. The study identified 32 plant species utilized in cosmetics, including Cannabis sativa L., Dittrichia viscosa (L.) Greuter, Juglans regia L., and Rubus fruticosus L. Leaves emerged as the most used plant parts, with decoction and infusion being the predominant preparation methods. This survey facilitated a comprehensive examination of ethnobotanical knowledge, shedding light on the primary plants employed in cosmetics. Prudent management of these resources is imperative to prevent future shortages.

Published
2024
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15. Herbal terpenoids in healthcare

Author

El Menyiy, Naoual, primary, El Omari, Nasreddine, additional, Balahbib, Abdelaali, additional, Benali, Taoufiq, additional, Guaouguaou, Fatima-Ezzahrae, additional, Charfi, Saoulajan, additional, and Bouyahya, Abdelhakim, additional

Published
2022
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18. Chemical composition and potential antioxidant, anti-inflammatory, and analgesic efficacy of Cistus albidus L.

Author

ZOUHRI, AZIZ, BOUDDINE, TOUFIK, EL MENYIY, NAOUAL, EL-MERNISSI, YAHYA, LAAROUSSI, HASSAN, CHEBAIBI, MOHAMED, AMHAMDI, HASSAN, ELHARRAK, ABDELHAY, NAFIDI, HIBA-ALLAH, SITOTAW, BAYE, BIN JARDAN, YOUSEF A., BOURHIA, MOHAMMED, HAJJI, LHOUSSAIN, ZOUHRI, AZIZ, BOUDDINE, TOUFIK, EL MENYIY, NAOUAL, EL-MERNISSI, YAHYA, LAAROUSSI, HASSAN, CHEBAIBI, MOHAMED, AMHAMDI, HASSAN, ELHARRAK, ABDELHAY, NAFIDI, HIBA-ALLAH, SITOTAW, BAYE, BIN JARDAN, YOUSEF A., BOURHIA, MOHAMMED, and HAJJI, LHOUSSAIN

Abstract

This study aims to assess the chemical composition of the aqueous extract of Cistus albidus L. leaves, as well as the potential of aqueous and hydroethanol extracts of the leaves and seeds as analgesic, anti-inflammatory, and antioxidant agents. The contents of phenolics and inorganic constituents were determined in C. albidus seeds and leaves; antioxidant capacity was assessed by 3 complementary and diverse tests. The carrageenan-induced paw edema technique was used to investigate the anti-inflammatory effect in vivo, and albumin denaturation to evaluate the anti-inflammatory effect in vitro. The acetic acid-induced contortion test, the tail-flick test, and the plantar test were used to assess the analgesic efficacy in vivo. Chemical analysis was performed by UPLC-MS/MS to quantify several phenolic compounds including catechin (1,627.6 mg kg–1), quercitrin (1,235.8 mg kg–1) and gallic acid (628. 2 mg kg–1). The ICP analysis revealed that potassium and calcium were the main inorganic components in the seeds and leaves of C. albidus. The hydroethanolic extract of the leaves showed the highest content of polyphenols/flavonoids, whereas the highest value of proanthocyanidins was detected in the aqueous extract of the seeds. All extracts showed potent antioxidant activity related to different phenolic compounds (quercetin, gallic acid, astragalin, catechin, and rutin). The aqueous extract of the leaves strongly inhibited paw edema (76.1 %) after 6 h of treatment and showed maximal inhibition of protein denaturation (191.0 µg mL–1 for 50 % inhibition) and analgesic activity in different nociceptive models. The presented data reveal that C. albidus extracts potentially show antioxidant, anti-inflammatory, and analgesic activities that could confirm the traditional use of this plant.

Published
2024

23. Recent Advances in the Chemical Composition and Biological Activities of Propolis.

Author

Belmehdi, Omar, El Menyiy, Naoual, Bouyahya, Abdelhakim, El Baaboua, Aicha, El Omari, Nasreddine, Gallo, Monica, Montesano, Domenico, Naviglio, Daniele, Zengin, Gokhan, Skali Senhaji, Nadia, Goh, Bey Hing, and Abrini, Jamal

Subjects
*PROPOLIS, *DOSAGE forms of drugs, *BIOACTIVE compounds, *HONEY plants, *DRUG development, *TRADITIONAL medicine, *ANTIPARASITIC agents
Abstract

Propolis is a resinous substance from beehive produced by the combination of plants and bee secretions. For a long time, this substance has gotten high attention in traditional and modern medicine. The aim of this review was to discuss the recent advances in the chemical composition and biological activities of propolis. The search for recent publications was based on several databases, such as PubMed, Google Scholar, Science-Direct, and Web of Sciences using relevant keywords. Literature data showed that several new compounds have recently been identified in propolis. The most important biological properties of propolis were discussed in this review, namely antibacterial, antiparasitic, antiviral, antioxidant, antileishmanial, anti-inflammatory, antidiabetic, immunomodulatory, and anticancer. In terms of safety, the data showed low toxicity of propolis even at high doses. Overall, propolis can be considered a promising source of bioactive compounds for drug development. [ABSTRACT FROM AUTHOR]

Published
2023
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25. Biological and Pharmacological Properties of Myrtenol: A Review

Author

Zengin, Gokhan, primary, Bouyahya, Abdelhakim, primary, Mrabti, Hanae Naceiri, additional, Jaouadi, Imane, additional, Zeouk, Ikrame, additional, Ghchime, Rokia, additional, El Menyiy, Naoual, additional, Omari, Nasreddine El, additional, Balahbib, Abdelaali, additional, Al-Mijalli, Samiah H., additional, Abdallah, Emad M., additional, and El-Shazly, Mohamed, additional

Published
2023
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26. Traditional Uses, Bioactive Compounds, and Pharmacological Investigations of Calendula arvensis L.: A Comprehensive Review

Author

Khouchlaa, Aya, primary, El Baaboua, Aicha, additional, El Moudden, Hamza, additional, Lakhdar, Fatima, additional, Bakrim, Saad, additional, El Menyiy, Naoual, additional, Belmehdi, Omar, additional, Harhar, Hicham, additional, El Omari, Nasreddine, additional, Balahbib, Abdelaali, additional, Park, Moon Nyeo, additional, Zengin, Gokhan, additional, Kim, Bonglee, additional, and Bouyahya, Abdelhakim, additional

Published
2023
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29. Targeting mTOR as a Cancer Therapy: Recent Advances in Natural Bioactive Compounds and Immunotherapy

Author

Bouyahya, Abdelhakim, primary, El Allam, Aicha, additional, Aboulaghras, Sara, additional, Bakrim, Saad, additional, El Menyiy, Naoual, additional, Alshahrani, Mohammed Merae, additional, Al Awadh, Ahmed Abdullah, additional, Benali, Taoufiq, additional, Lee, Learn-Han, additional, El Omari, Nasreddine, additional, Goh, Khang Wen, additional, Ming, Long Chiau, additional, and Mubarak, Mohammad S., additional

Published
2022
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30. Syzygium aromaticum: Traditional uses, antioxidant, anti-inflammatory activities and photo-protective properties

Author

Zouhri, Aziz, Bouddine, Toufik, El Menyiy, Naoual, El-Mernissi, Yahya, El-Akhal, Jamila, Hajji, Lhoussain, and Amhamdi, Hassan

Subjects
Antioxidant, Carrageenan, Fixed oil, Syzygium aromaticum, Ultraviolet
Abstract

Syzygium aromaticum (L.) communément appelé clou de girofle appartient à la famille des Myrtacées utilisées en médecine traditionnelle marocaine comme diurétiques, analgésiques, anti-inflammatoires et pour traiter les problèmes dentaires. L'objectif de cette étude est d'évaluer les activités biologiques des huiles fixées des bourgeons de Syzygium aromaticum . Le spectrophotomètre UV-Visible a été utilisé pour évaluer l'activité photo-protectrice de l'huile fixée à travers le test d'absorbance UV. Nous avons prouvé que l'huile fixe et l'extrait d'acétate d'éthyle de clou de girofle ont une haute capacité d'absorption des UVB. L'étude de l'huile fixée in vitro a montré qu'elle possède une capacité antioxydante importante en inhibant les radicaux libres DPPH. A noter que la valeur maximale de cette activité est de 95,13 % (IC50 = 0,163 mg/ml.). L'activité anti-inflammatoire de l'huile fixée de Syzygium aromaticum a été évaluée chez le lapin par le test d'inflammation induit par l'injection de carraghénane. Les résultats montrent que l'effet inhibiteur maximal de l'huile fixe sur l'inflammation était de 87,7% atteint à la cinquième heure., Arabian Journal of Medicinal and Aromatic Plants, مجلد 8, عدد 3 (2022)

Published
2022
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31. Pharmacological Properties of Trichostatin A, Focusing on the Anticancer Potential: A Comprehensive Review

Author

Bouyahya, Abdelhakim, primary, El Omari, Nasreddine, additional, Bakha, Mohamed, additional, Aanniz, Tarik, additional, El Menyiy, Naoual, additional, El Hachlafi, Naoufal, additional, El Baaboua, Aicha, additional, El-Shazly, Mohamed, additional, Alshahrani, Mohammed Merae, additional, Al Awadh, Ahmed Abdullah, additional, Lee, Learn-Han, additional, Benali, Taoufiq, additional, and Mubarak, Mohammad S., additional

Published
2022
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32. Determination of Chemical Compounds and Investigation of Biological Properties of Matricaria chamomilla Essential Oils, Honey, and Their Mixture

Author

Qasem, Ahmed, primary, Assaggaf, Hamza, additional, Montesano, Domenico, additional, Khalil, Zineb, additional, Al-Mijalli, Samiah Hamad, additional, Baaboua, Aicha EL, additional, El Omari, Nasreddine, additional, El Menyiy, Naoual, additional, Bakrim, Saad, additional, Sheikh, Ryan A., additional, Alshahrani, Mohammed Merae, additional, Awadh, Ahmed Abdullah Al, additional, Zengin, Gokhan, additional, Bouyahya, Abdelhakim, additional, and Mrabti, Hanae Naceiri, additional

Published
2022
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33. Chemical Analysis and Investigation of Biological Effects of Salvia officinalis Essential Oils at Three Phenological Stages

Author

Assaggaf, Hamza M., primary, Naceiri Mrabti, Hanae, additional, Rajab, Bodour S., additional, Attar, Ammar A., additional, Alyamani, Reema A., additional, Hamed, Munerah, additional, El Omari, Nasreddine, additional, El Menyiy, Naoual, additional, Hazzoumi, Zakaria, additional, Benali, Taoufiq, additional, Al-Mijalli, Samiah Hamad, additional, Zengin, Gokhan, additional, AlDhaheri, Yusra, additional, Eid, Ali H., additional, and Bouyahya, Abdelhakim, additional

Published
2022
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34. Indigenous Knowledge of the Traditional Use of Aromatic and Medicinal Plants in Rif Mountains Ketama District.

Author

El-Mernissi, Yahya, Zouhri, Aziz, Labhar, Amina, El Menyiy, Naoual, Ahari, M'hamed, El Barkany, Soufian, Salhi, Amin, Bouyahya, Abdelhakim, Hajji, Lhoussain, and Amhamdi, Hassan

Subjects
PHYTOTHERAPY, HERBAL medicine, FOCUS groups, DIGESTIVE system diseases, RESEARCH methodology, PHARMACOLOGY, ORAL drug administration, INTERVIEWING, QUANTITATIVE research, TRADITIONAL medicine, PRIMARY health care, SURVEYS, INTELLECT, QUESTIONNAIRES, DESCRIPTIVE statistics, LEAVES, THYMES, ROSEMARY, OREGANO
Abstract

Background. Medicinal plants have long played an integral role in traditional healing systems and are crucial for meeting primary healthcare needs. This study aimed to investigate the use of medicinal plants in phytotherapy in the Ketama region of Northern Morocco. Methods. Ethnobotanical data and ancestral knowledge regarding plants were collected through a field survey conducted from August 2019 to July 2021. The data were gathered using a standardized questionnaire, as well as through semistructured interviews and focus groups. Various ethnobotanical indices were applied to analyse the information collected. Results. A comprehensive inventory identified a total of 81 plant species, belonging to 40 families and 65 genera. These species are used primarily to treat a variety of diseases. Notably, digestive disorders ranked first among the diseases treated, with an ICF value of 0.618. Rosmarinus officinalis L., Thymus serpyllum L., and Origanum compactum Benth exhibited the highest UV values among medicinal plants. Leaves were the most used part of the plant part (50.28%), and the decoction method was the most recommended preparation, with oral administration being the preferred mode of application of the remedy. Conclusion. The Ketama region boasts a rich abundance of medicinal and aromatic plants, as evident from the quantitative analysis highlighting the significant usage of Rosmarinus officinalis L., Thymus serpyllum L., and Origanum compactum Benth. by the local population. However, further research in the form of pharmacological studies is necessary to validate their therapeutic effects. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Bioactive compounds from Prosopis species as potential oxidative stress and inflammation modulators: an update on mechanisms.

Author

SHARIFI-RAD, Javad, EL MENYIY, Naoual, YDYRYS, Alibek, EL HACHLAFI, Naoufal, EL OMARI, Nasreddine, ALDAHISH, Afaf A., SHAROPOV, Farukh, BOUYAHYA, Abdelhakim, ŽIVKOVIĆ, Jelena, ADETUNJI, Charles O., OLANIYAN, Olugbemi T., MARTORELL, Miquel, SÖNMEZ GÜRER, Eda, HANO, Christophe, and CALINA, Daniela

Subjects
*OXIDATIVE stress, *MESQUITE, *BIOACTIVE compounds, *OXIDANT status, *SCIENCE databases
Abstract

Oxidative stress and inflammation processes are involved in most diseases and illnesses. Many herbal remedies have been shown to have anti-inflammatory and antioxidant effects, and have been used since ancient times as traditional medicine. Species of the genus Prosopis are one of these herbal remedies that grow in arid, semiarid, subtropical, and tropical areas of the world. Paste, gum, and smoke from pods and leaves of Prosopis plants are traditionally used to treat diseases related to oxidative stress and inflammation. This review aims to provide up-to-date information on Prosopis plants as oxidative stress and inflammation modulators. Relevant information was collected from researching scientific databases such as PubMed/Medline, Wiley, Web of Science and Springer. Folk medicinal applications and biologically active molecules of Prosopis spp., and its derivatives, have been collected paying attention to studies that used verified markers of oxidative stress, antioxidant capacity and inflammation. Future studies are needed to deepen more pharmacodynamic, pharmacokinetic and structure-activity relationships of phytochemicals isolated from Prosopis species. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Recent Advances in the Chemical Composition and Biological Activities of Propolis

Author

Belmehdi, Omar, primary, El Menyiy, Naoual, additional, Bouyahya, Abdelhakim, additional, El Baaboua, Aicha, additional, El Omari, Nasreddine, additional, Gallo, Monica, additional, Montesano, Domenico, additional, Naviglio, Daniele, additional, Zengin, Gokhan, additional, Skali Senhaji, Nadia, additional, Goh, Bey Hing, additional, and Abrini, Jamal, additional

Published
2022
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37. Inflammatory auto-immune diseases of the intestine and their management by natural bioactive compounds

Author

El Menyiy, Naoual, primary, El Allam, Aicha, additional, Aboulaghras, Sara, additional, Jaouadi, Imane, additional, Bakrim, Saad, additional, El Omari, Nasreddine, additional, Shariati, Mohammad Ali, additional, Miftakhutdinov, Alevtin, additional, Wilairatana, Polrat, additional, Mubarak, Mohammad S., additional, and Bouyahya, Abdelhakim, additional

Published
2022
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38. Natural Sources, Pharmacological Properties, and Health Benefits of Daucosterol: Versatility of Actions

Author

El Omari, Nasreddine, primary, Jaouadi, Imane, additional, Lahyaoui, Manal, additional, Benali, Taoufiq, additional, Taha, Douae, additional, Bakrim, Saad, additional, El Menyiy, Naoual, additional, El Kamari, Fatima, additional, Zengin, Gökhan, additional, Bangar, Sneh Punia, additional, Lorenzo, José M., additional, Gallo, Monica, additional, Montesano, Domenico, additional, and Bouyahya, Abdelhakim, additional

Published
2022
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39. Phytochemistry and Biological Properties of Salvia verbenaca L.: A Comprehensive Review

Author

Mrabti, Hanae Naceiri, primary, El Menyiy, Naoual, additional, Charfi, Saoulajan, additional, Saber, Mohammed, additional, Bakrim, Saad, additional, Alyamani, Reema A., additional, Rauf, Abdur, additional, Ali, Ahmed M. H., additional, Abdallah, Emad M., additional, El Omari, Naserddine, additional, Bouyahya, Abdelhakim, additional, and Assaggaf, Hamza, additional

Published
2022
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40. Chemical Compounds of Berry-Derived Polyphenols and Their Effects on Gut Microbiota, Inflammation, and Cancer

Author

Bouyahya, Abdelhakim, primary, Omari, Nasreddine El, additional, EL Hachlafi, Naoufal, additional, Jemly, Meryem El, additional, Hakkour, Maryam, additional, Balahbib, Abdelaali, additional, El Menyiy, Naoual, additional, Bakrim, Saad, additional, Naceiri Mrabti, Hanae, additional, Khouchlaa, Aya, additional, Mahomoodally, Mohamad Fawzi, additional, Catauro, Michelina, additional, Montesano, Domenico, additional, and Zengin, Gokhan, additional

Published
2022
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41. Medicinal Uses, Phytochemistry, Pharmacology, and Toxicology of Mentha spicata

Author

El Menyiy, Naoual, primary, Mrabti, Hanae Naceiri, additional, El Omari, Nasreddine, additional, Bakili, Afaf EI, additional, Bakrim, Saad, additional, Mekkaoui, Mouna, additional, Balahbib, Abdelaali, additional, Amiri-Ardekani, Ehsan, additional, Ullah, Riaz, additional, Alqahtani, Ali S., additional, Shahat, Abdelaaty A., additional, and Bouyahya, Abdelhakim, additional

Published
2022
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42. Ethnobotany, Phytochemistry, Biological Activities, and Health-Promoting Effects of the Genus Bulbophyllum

Author

Sharifi-Rad, Javad, primary, Quispe, Cristina, additional, Bouyahya, Abdelhakim, additional, El Menyiy, Naoual, additional, El Omari, Nasreddine, additional, Shahinozzaman, Md, additional, Ara Haque Ovey, Mim, additional, Koirala, Niranjan, additional, Panthi, Mamata, additional, Ertani, Andrea, additional, Nicola, Silvana, additional, Lapava, Natallia, additional, Herrera-Bravo, Jesús, additional, Salazar, Luis A., additional, Changan, Sushil, additional, Kumar, Manoj, additional, and Calina, Daniela, additional

Published
2022
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46. Sources, health benefits, and biological properties of zeaxanthin

Author

Bouyahya, Abdelhakim, primary, El Omari, Nasreddine, additional, Hakkur, Meryem, additional, El Hachlafi, Naoufal, additional, Charfi, Saoulajan, additional, Balahbib, Abdelaali, additional, Guaouguaou, Fatima-Ezzahrae, additional, Rebezov, Maksim, additional, Maksimiuk, Nikolai, additional, Shariati, Mohammad Ali, additional, Zengin, Gokhan, additional, El Menyiy, Naoual, additional, Chamkhi, Imane, additional, and Bakrim, Saad, additional

Published
2021
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49. Preclinical and Clinical Antioxidant Effects of Natural Compounds against Oxidative Stress-Induced Epigenetic Instability in Tumor Cells

Author

Bouyahya, Abdelhakim, primary, El Menyiy, Naoual, additional, Oumeslakht, Loubna, additional, El Allam, Aicha, additional, Balahbib, Abdelaali, additional, Rauf, Abdur, additional, Muhammad, Naveed, additional, Kuznetsova, Elena, additional, Derkho, Marina, additional, Thiruvengadam, Muthu, additional, Shariati, Mohammad Ali, additional, and El Omari, Nasreddine, additional

Published
2021
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