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1. A novel β-lactam derivative, albactam from the flowers of Albizia lebbeck with platelets anti-aggregatory activity in vitro.

Author

El Gamal, Ali Ali, Abd El Halim, Mohamed Farag, Kalil, Ashraf Taha, Basudan, Omer Ahmed, Al-Rehaily, Adnan Jathlan, Ahmad, Mohamed Shamim, El Tahir, Kamal Hussin, Al-Massarani, Shaza Mohamed, and Abdel-Mageed, Wael Moustafa

Abstract

A novel β-lactam derivative, albactam, was isolated from the alcoholic extract of the flowers of Albizia lebbeck. It showed a significant anti-aggregatory activity against adenosine diphosphate and arachidonic acid induced guinea-pigs' platelets aggregation in vitro. Six more known compounds were also isolated and fully characterized by measuring 1D and 2D NMR, two of them are the triterpenes β- amyrin and 11α, 12α-oxidotaraxerol, two ceramide derivatives and two flavonoids, kampferol 3-O-rutinoside and rutin. [ABSTRACT FROM AUTHOR]

Published
2015

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