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494 results on '"El-Hage W"'

1. Neural correlates of delusional infestation responding to aripiprazole monotherapy: a case report

Author

Ponson L, Andersson F, and El-Hage W

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Laura Ponson,1,2 Frédéric Andersson,1 Wissam El-Hage1,2 1Université François-Rabelais de Tours, Inserm, Imagerie et Cerveau UMR U930, Tours, France, 2CHRU de Tours, Clinique Psychiatrique Universitaire, Tours, France Background: The pathophysiology and appropriate pharmacological interventions for delusional infestation remain unknown.Case presentation: Here, we report a case of primary delusional infestation successfully treated with aripiprazole. We performed functional magnetic resonance imaging (fMRI) to investigate brain structures and functional modifications. Before antipsychotic treatment, pre- versus post-treatment fMRI images revealed a marked increase in brain activation in the supplementary motor area (SMA).Conclusion: Our results highlight the efficacy and safety of aripiprazole in the treatment of delusional infestation and the possible role of SMA dysfunction in delusional infestation. Indeed, our results suggest that psychiatric improvement of delusional infestation is associated with normalization of brain activity, particularly in the SMA. Keywords: supplementary motor area, antipsychotics, fMRI

Published
2015

13. Childhood Trauma increases suicidal behaviour in a treatment-resistant depression population: a FACE-DR report

Author

Aouizerate, B., Bennabi, D., Leboyer, M., Haffen, E., Llorca, P.M., Barteau, V., Bensalem, S., Laouamri, H., Souryis, Karmene, Mallet, L., Yon, L., Petrucci, J., Genty, J.B., Yrondi, A., Pierre, D., Schmitt, L., Sarrail, M., Bennabi, Djamila, Ryff, I., Beuchet, E., Tio, G., Cappe, C., Clerc, E., Garnier, M., Honciuc, R.M., Allauze, E., Blanc, O., Bellivier, F., Allaili, N., Nieto, I., Meheust, J., Sunthavy, Y., Maruani, J., Bougerol, T., Polosan, M., Courvoisier, P., Holtzmann, J., Fredembach, B., Foubert-Andreani, S., Camus, V., El Hage, W., D’Amato, T., Haesebaert, F., Dubien, C., Lefebvre, M., Meznad, A., Brunelin, J., Moirand, R., Doumy, O., Lancon, C., Richieri, R., Peri, P., Faugere, M., Faget-Agius, C., Courtet, P., Boulenger, J.P., Moliere, F., Stephan, F., Walter, M., Mesmeur, C., Vaiva, G., Horn, M., Yrondi, Antoine, Vaiva, Guillaume, Walter, Michel, D Amato, Thierry, Bellivier, Frank, Bougerol, Thierry, Camus, Vincent, Doumy, Olivier, Genty, Jean-Baptiste, Haffen, Emmanuel, Holtzmann, Jérôme, Horn, Mathilde, Lançon, Christophe, Leboyer, Marion, Llorca, Pierre-Michel, Maruani, Julia, Moirand, Rémi, Molière, Fanny, Petrucci, Jean, Richieri, Raphaelle, Samalin, Ludovic, Schmitt, Laurent, Stephan, Florian, Courtet, Philippe, El-Hage, Wissam, and Aouizerate, Bruno

Published
2021
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18. Adherence to treatment guidelines in clinical practice for using electroconvulsive therapy in major depressive episode

Author

Samalin, L, Yrondi, A, Charpeaud, T, Genty, JB, Blanc, O, Sauvaget, A, Stéphan, F, Walter, M, Bennabi, D, Bulteau, S, Haesebaert, F, D'Amato, T, Poulet, E, Holtzmann, J, Richieri, RM, Attal, J, Nieto, I, El-Hage, W, Bellivier, F, Schmitt, L, Lançon, C, Bougerol, T, Leboyer, M, Aouizerate, B, Haffen, E, Courtet, P, and Llorca, PM

Published
2020
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20. Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup

Author

Huggins, AA, Baird, CL, Briggs, M, Laskowitz, S, Hussain, A, Fouda, S, Haswell, C, Sun, D, Salminen, LE, Jahanshad, N, Thomopoulos, SI, Veltman, DJ, Frijling, JL, Olff, M, van Zuiden, M, Koch, SBJ, Nawjin, L, Wang, L, Zhu, Y, Li, G, Stein, DJ, Ipser, J, Seedat, S, du Plessis, S, van den Heuvel, LL, Suarez-Jimenez, B, Zhu, X, Kim, Y, He, X, Zilcha-Mano, S, Lazarov, A, Neria, Y, Stevens, JS, Ressler, KJ, Jovanovic, T, van Rooij, SJH, Fani, N, Hudson, AR, Mueller, SC, Sierk, A, Manthey, A, Walter, H, Daniels, JK, Schmahl, C, Herzog, JI, Říha, P, Rektor, I, Lebois, LAM, Kaufman, ML, Olson, EA, Baker, JT, Rosso, IM, King, AP, Liberzon, I, Angstadt, M, Davenport, ND, Sponheim, SR, Disner, SG, Straube, T, Hofmann, D, Qi, R, Lu, GM, Baugh, LA, Forster, GL, Simons, RM, Simons, JS, Magnotta, VA, Fercho, KA, Maron-Katz, A, Etkin, A, Cotton, AS, O’Leary, EN, Xie, H, Wang, X, Quidé, Y, El-Hage, W, Lissek, S, Berg, H, Bruce, S, Cisler, J, Ross, M, Herringa, RJ, Grupe, DW, Nitschke, JB, Davidson, RJ, Larson, CL, deRoon-Cassini, TA, Tomas, CW, Fitzgerald, JM, Blackford, JU, Olatunji, BO, Kremen, WS, Lyons, MJ, Franz, CE, Gordon, EM, May, G, Nelson, SM, Abdallah, CG, Levy, I, Harpaz-Rotem, I, Quide, Yann ; https://orcid.org/0000-0002-8569-7139, Huggins, AA, Baird, CL, Briggs, M, Laskowitz, S, Hussain, A, Fouda, S, Haswell, C, Sun, D, Salminen, LE, Jahanshad, N, Thomopoulos, SI, Veltman, DJ, Frijling, JL, Olff, M, van Zuiden, M, Koch, SBJ, Nawjin, L, Wang, L, Zhu, Y, Li, G, Stein, DJ, Ipser, J, Seedat, S, du Plessis, S, van den Heuvel, LL, Suarez-Jimenez, B, Zhu, X, Kim, Y, He, X, Zilcha-Mano, S, Lazarov, A, Neria, Y, Stevens, JS, Ressler, KJ, Jovanovic, T, van Rooij, SJH, Fani, N, Hudson, AR, Mueller, SC, Sierk, A, Manthey, A, Walter, H, Daniels, JK, Schmahl, C, Herzog, JI, Říha, P, Rektor, I, Lebois, LAM, Kaufman, ML, Olson, EA, Baker, JT, Rosso, IM, King, AP, Liberzon, I, Angstadt, M, Davenport, ND, Sponheim, SR, Disner, SG, Straube, T, Hofmann, D, Qi, R, Lu, GM, Baugh, LA, Forster, GL, Simons, RM, Simons, JS, Magnotta, VA, Fercho, KA, Maron-Katz, A, Etkin, A, Cotton, AS, O’Leary, EN, Xie, H, Wang, X, Quidé, Y, El-Hage, W, Lissek, S, Berg, H, Bruce, S, Cisler, J, Ross, M, Herringa, RJ, Grupe, DW, Nitschke, JB, Davidson, RJ, Larson, CL, deRoon-Cassini, TA, Tomas, CW, Fitzgerald, JM, Blackford, JU, Olatunji, BO, Kremen, WS, Lyons, MJ, Franz, CE, Gordon, EM, May, G, Nelson, SM, Abdallah, CG, Levy, I, Harpaz-Rotem, I, and Quide, Yann ; https://orcid.org/0000-0002-8569-7139

Abstract

Although the cerebellum contributes to higher-order cognitive and emotional functions relevant to posttraumatic stress disorder (PTSD), prior research on cerebellar volume in PTSD is scant, particularly when considering subregions that differentially map on to motor, cognitive, and affective functions. In a sample of 4215 adults (PTSD n = 1642; Control n = 2573) across 40 sites from the ENIGMA-PGC PTSD working group, we employed a new state-of-the-art deep-learning based approach for automatic cerebellar parcellation to obtain volumetric estimates for the total cerebellum and 28 subregions. Linear mixed effects models controlling for age, gender, intracranial volume, and site were used to compare cerebellum volumes in PTSD compared to healthy controls (88% trauma-exposed). PTSD was associated with significant grey and white matter reductions of the cerebellum. Compared to controls, people with PTSD demonstrated smaller total cerebellum volume, as well as reduced volume in subregions primarily within the posterior lobe (lobule VIIB, crus II), vermis (VI, VIII), flocculonodular lobe (lobule X), and corpus medullare (all p -FDR < 0.05). Effects of PTSD on volume were consistent, and generally more robust, when examining symptom severity rather than diagnostic status. These findings implicate regionally specific cerebellar volumetric differences in the pathophysiology of PTSD. The cerebellum appears to play an important role in higher-order cognitive and emotional processes, far beyond its historical association with vestibulomotor function. Further examination of the cerebellum in trauma-related psychopathology will help to clarify how cerebellar structure and function may disrupt cognitive and affective processes at the center of translational models for PTSD.

Published
2024

26. Prise en charge des troubles dépressifs résistants : recommandations françaises formalisées par des experts de l’AFPBN et de la fondation FondaMental

Author

Charpeaud, T., Genty, J.-B., Destouches, S., Yrondi, A., Lancrenon, S., Alaïli, N., Bellivier, F., Bennabi, D., Bougerol, T., Camus, V., D’amato, T., Doumy, O., Haesebaert, F., Holtzmann, J., Lançon, C., Lefebvre, M., Moliere, F., Nieto, I., Richieri, R., Schmitt, L., Stephan, F., Vaiva, G., Walter, M., Leboyer, M., El-Hage, W., Haffen, E., Llorca, P.-M., Courtet, P., and Aouizerate, B.

Published
2017
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32. Clinical guidelines for the management of depression with specific comorbid psychiatric conditions French recommendations from experts (the French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental)

Author

Bennabi, D., Yrondi, A., Charpeaud, T., Genty, J.-B., Destouches, S., Lancrenon, S., Allaili, N., Bellivier, F., Bougerol, T., Camus, V., Doumy, O., Dorey, J.-M., Haesebaert, F., Holtzmann, J., Lançon, C., Lefebvre, M., Moliere, F., Nieto, I., Rabu, C., Richieri, R., Schmitt, L., Stephan, F., Vaiva, G., Walter, M., Leboyer, M., El-Hage, W., Aouizerate, B., Haffen, E., Llorca, P.-M., and Courtet, P.

Published
2019
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33. Clinical guidelines for the management of treatment-resistant depression: French recommendations from experts, the French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental

Author

Bennabi, D., Charpeaud, T., Yrondi, A., Genty, J.-B., Destouches, S., Lancrenon, S., Alaïli, N., Bellivier, F., Bougerol, T., Camus, V., Dorey, J.-M., Doumy, O., Haesebaert, F., Holtzmann, J., Lançon, C., Lefebvre, M., Moliere, F., Nieto, I., Rabu, C., Richieri, R., Schmitt, L., Stephan, F., Vaiva, G., Walter, M., Leboyer, M., El-Hage, W., Llorca, P.-M., Courtet, P., Aouizerate, B., and Haffen, E.

Published
2019
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34. Disentangling the Link Between Mindfulness and Dissociation in PTSD: The Mediating Role of Attention and Emotional Acceptance.

Author

Vancappel, A, Hingray, C, Reveillere, C, and El-Hage, W

Subjects
TREATMENT of post-traumatic stress disorder, MINDFULNESS, ADVERSE childhood experiences, CONFIDENCE intervals, DISSOCIATIVE disorders, SELF-evaluation, COGNITION, RISK assessment, ATTENTION, QUESTIONNAIRES, DESCRIPTIVE statistics, AFFECTIVE disorders, FACTOR analysis, EMOTION regulation
Abstract

A number of studies have investigated the relationship between mindfulness and dissociation and suggested that mindfulness-based interventions could be effective in the treatment of dissociative symptoms. A recent study in healthy volunteers found that attention and emotional acceptance mediates this relationship. However, no study has yet been performed among a clinical sample to assess this association. We recruited 90 patients (76 women) suffering from Posttraumatic Stress Disorder (PTSD). They completed self-report questionnaires to measure PTSD, dissociation, emotion regulation difficulties, childhood trauma, mindfulness abilities and cognitive abilities. We found that mindfulness abilities, emotional difficulties, dissociation and attention-concentration were all related to each other. Using a step-by-step approach and bootstrapping techniques, we found a significant indirect effect of mindfulness abilities on dissociation through non-acceptance (confidence interval 95%=-.14 to −.01) and attentional difficulties (confidence interval 95%=-.23 to −.05). Patients with higher levels of dissociative symptoms have less capacity for mindfulness. Our results support Bishop et al.'s model proposing that attention and emotional acceptance are the two active components of mindfulness. To extend our findings, clinical trials are required to evaluate a causal relationship and the effectiveness of mindfulness-based interventions for patients suffering from dissociation. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Development and validation of the Symptomatic Transdiagnostic Test (S2T)

Author

Vancappel, A., primary, Raysseguier, C., additional, Coillot, H., additional, Jansen, E., additional, Bouyer, C., additional, Mangolini, A., additional, Barbe, P.G., additional, Debout-Courtault, C., additional, Pierre-le Seac’h, M., additional, Kazour, F., additional, Courtois, R., additional, and El-Hage, W., additional

Published
2023
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42. Inhibition, Attentional Control and Binding Abilities in Relation to Dissociative Symptoms Among PTSD Patients.

Author

Vancappel, A, Raysseguier, C, Révellière, C, Penverne, T, Fernandes, R, and El-Hage, W

Subjects
MEMORY, DISSOCIATIVE disorders, RESEARCH methodology evaluation, RESEARCH methodology, POST-traumatic stress disorder, TASK performance, NEUROPSYCHOLOGICAL tests, ATTENTION, DESCRIPTIVE statistics, QUESTIONNAIRES, COGNITIVE testing, EMOTIONS, CONTROL (Psychology)
Abstract

The relationship between dissociation and cognitive abilities remains controversial. Empirical studies have reported positive, negative and non-existent associations between dissociation and cognition. These inconsistent results may be due to the fact that the studies focused mainly on trait dissociation, while dissociation is not stable but transient. After validating the French version of the Clinician Administered Dissociative States Scale (CADSS), the aim of the present study was to evaluate the relationship between state dissociation and cognitive abilities. We recruited 83 patients suffering from post-traumatic stress disorder (PTSD) and assessed them twice. At T1, they performed a neutral Stroop task and a neutral binding task. At T2 (one to three weeks later), after a script-driven dissociative induction, they performed an emotional Stroop task and an emotional binding task. Between the two sessions, they completed questionnaires at home evaluating PTSD severity, trait dissociation and cognitive difficulties. State dissociation was assessed at T1 and T2 using the Clinician-Administered Dissociative States Scale (CADSS). We found good psychometric properties of the French version of the CADSS. After inducing dissociation, significantly lower attentional performance was found among patients with than without dissociative reactions. We found a significant positive correlation between state dissociation and increased attention and memory difficulties after induction. The French version of the CADSS is a reliable and valid tool to assess state dissociation, which is correlated with attentional difficulties. Attentional training is recommended to help patients control dissociative symptoms. [ABSTRACT FROM AUTHOR]

Published
2023
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