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The guidelines contain information on the prevention and treatment of arterial hypotension during cesarean section under neuraxial anesthesia. Vasopressors, elastic compression of lower extremities, co-infusion of crystalloids, low doses of local anesthetics, lateral position, and ondansetron are proposed. A positive effect is achieved only through the joint application of preventive measures.

Erysipelas, a variant of cellulitis, is a superficial dermal bacterial infection. This superficial cutaneous infection may cause lymphangitis with resultant lymphedema in poorly treated cases. Reports of erysipelas preceding lymphedema are rare, rather many have reported the occurrence of erysipelas in patients with subclinical or overt lymphedema. Two case reports of erysipelas preceding lymphedema after appropriate parenteral antibiotics therapy and limb elevation are here presented. Following diagnosis, admission, and commencement of therapy, the second patient (Case 2) discontinued hospital treatment halfway for native treatment and returned after about 3 weeks. All patients recovered successfully but later presented with lymphedema after 8 weeks and 6 weeks, respectively. Both patients made a sustained functional recovery of their limbs with conservative management including elastic compression stocking and limb elevation. Erysipelas infection preceding lymphedema may develop when it occurs, prompt and appropriate treatment modalities for erysipelas infection may forestall the development of lymphedema.

Introduction/Objective. The objective of the paper is an assessment of the effect of graduated elastic compression stockings on clinical findings, complications, and inflammatory and thrombotic markers in patients with superficial vein thrombophlebitis. Methods. This prospective study was conducted between January and July of 2017, at the Clinic for Vascular and Endovascular Surgery of the Clinical Centre of Serbia. All the patients were clinically examined, and color duplex ultrasonography of the superficial and deep venous systems was performed. In all cases, we follow clinical finding, inflammatory and thrombotic markers, and superficial vein thrombosis (SVT) complication. Results. SVT was detected in 60 patients (36 women, aged 23?75 years and 24 men, aged 18?76 years. Most patients were with unilateral, subacute, above-knee located SVT. Regarding the typical clinical symptoms of SVT, patients were divided into four groups. The majority of our patients (group D) had all the symptoms associated. Regarding the severity of SVT and risk factors, the patients were divided into a greater risk group (Group I) and a lesser risk group (Group II), and treated with low-molecular-weight heparin, aspirin and two classes of graduated elastic compression stockings regarding the level of SVT. Laboratory testing of inflammatory and thrombotic markers in patients with SVT was performed at the beginning and at the end of therapy. Conclusions. In treatment of SVT, higher class of graduated compression therapy has stronger influence in decrement of inflammatory and thrombotic factors and prompt and adequately chosen therapy of SVT allows stoppage and regression of the thrombotic process.

Symptoms of chronic venous insufficiency have been known since antiquity. The prevalence of chronic venous insufficiency in Western Europe and the USA has been reported within the range from from 1 to 40% in women and from 1 to 17% in men [1]. As reported by the European authors, the average prevalence of chronic venous insufficiency with class C2-C6 (according to the CEAP classification) among the European population reaches 30% [2]. Edema syndrome remains one of the leading manifestations of chronic venous disease. Compression therapy is one of the main ways to combat edema. The arsenal of devices for the treatment of edematous syndrome is steadily expanding with the development of medical science. Today, in addition to inelastic compression wrap and elastic compression garments, brand-new compression products, circaid adjustable inelastic compression wraps are available.

ObjectivesElastic compression stocking (ECS) therapy is an important treatment for patients with deep venous thrombosis (DVT) and chronic venous insufficiency (CVI). This study aimed to provide insight into the structure and variability of the ECS therapy process, its effects on outcomes, and to elicit improvement themes from a multiple stakeholder perspective.DesignThirty semi-structured interviews with professionals and patients were performed. The essential functions for the process of ECS therapy were extracted to create two work-as-done models using the Functional Resonance Analysis Method (FRAM). These findings were used to guide discussion between stakeholders to identify improvement themes.SettingTwo regions in the Netherlands, region Limburg and region North-Holland, including an academic hospital and a general hospital and their catchment region.ParticipantsThe interviewees were purposely recruited and included 25 healthcare professionals (ie, general practitioners, internists, dermatologists, nurses, doctor’s assistants, occupational therapists, home care nurses and medical stocking suppliers) and 5 patients with DVT or CVI.ResultsTwo FRAM models were created (one for each region). The variability of the functions and their effect on outcomes, as well as interdependencies between functions, were identified. These were presented in stakeholder meetings to identify the structure of the process and designated variable and uniform parts of the process and its outcomes. Ultimately, six improvement themes were identified: dissemination of knowledge of the entire process; optimising and standardising initial compression therapy; optimising timing to contact the medical stocking supplier (when oedema has disappeared); improving the implementation of assistive devices; harmonising follow-up duration for patients with CVI; personalising follow-up and treatment duration in patients with DVT.ConclusionsThis study provided a detailed understanding of how ECS therapy is delivered in daily practice by describing major functions and variability in performances and elicited six improvement themes from a multistakeholder perspective.

Summary. Background: Theoretically progressive compression stockings, which produce a higher compression at the calf than at the ankle level, improve venous return flow without exacerbating peripheral arterial insufficiency (PAD). We aimed to evaluate the short-term tolerance of elastic progressive compression stockings on peripheral arterial vascularisation in patients with symptomatic PAD and associated mild venous insufficiency. Patients and methods: Monocentric, prospective, open pilot study of 18 patients (acceptability study, 6 x 6 plan) evaluating the short-term tolerance of progressive compression stockings (18 ± 2 mmHg at calf and 8 ± 2 mmHg at ankle level) in patients with PAD (ankle brachial index ABI > 0.60 15 % of ABI on each side, no decrease > 15 % of toe brachial index (TBI) on each side and no decrease > 25 % of the number of active plantar flexions performed while standing. Results: The proportion of men was 77.8 %, mean age was 77.3 ± 7.5 years and no patient were diabetic. At inclusion, the mean low ABI was 0.60 ± 0.04 and the mean high ABI was 0.77 ± 0.18. The mean low TBI was 0.32 ± 0.09 and the mean high TBI 0.46 ± 0.15. The mean number of active standing plantar flexions was 33.0 ± 5.0. The majority of the patients were classified in CEAP C2s and C3 classes (class 2: 16.7 %, class C2s: 27.8 %, class C3: 44.4 %, class C4: 5.6 % and class C4s: 5.6 %). Poor tolerance occurred in no patient. By day 30, no patient had worsening of their arterial and venous symptoms. No adverse events occurred during the study. Conclusions: These results suggest a high tolerance of progressive elastic stockings (18 ± 2 mmHg at calf and 8 ± 2 mmHg at ankle level) in symptomatic PAD.

The settlement calculation of postgrouting piles is complex and depends on the calculation method and parameters. Static load tests were conducted to compare the settlement characteristics of nongrouting and postgrouting piles, and three vital parameters in the layer-wise summation method were revised to predict the settlement of postgrouting piles. The elastic compression coefficient was deduced based on the Mindlin–Geddes method by considering the influence of the change in the pile side resistance distribution and end resistance ratio on the elastic compression after grouting. The relationship between the compression modulus and soil gravity stress and cone penetration resistance were established, respectively, using experimental data. The optimum value of the settlement empirical coefficient was determined using regional data. Finally, we used the postgrouting pile of the Wuqi–Dingbian expressway as a practical example. The results obtained from the layer-wise summation method after parametric optimization were close to the measured values. The results of this study provide reference data and guidance for the settlement calculation of postgrouting piles in this area.

Background: Elastic compression stockings (ECS) are uncomfortable to wear but may prevent post-thrombotic syndrome (PTS). The ability to predict PTS may help clinical decision making regarding the optimal duration of ECS after deep vein thrombosis (DVT). Aims: Predefined endpoint analysis of the Octavia study that randomized patients who compliantly used ECS up to one year after DVT to continue or discontinue ECS treatment. Primary aim was to identify predictors of PTS. Methods: Patient characteristics were collected and ultrasonography was performed to assess reflux, residual thrombosis and persistent thrombus load 12 months after DVT. Multivariable analyses were performed to identify factors related to PTS. Results: Thrombus score ≥ 3, BMI ≥ 26, duration of symptoms before DVT diagnosis ≥ 8 days and a Villalta score of 2–4 points were statistically significant predictors of PTS. The predictive value for PTS for the assessed variables was not different between the 2 treatment groups. In the stop ECS group, 3.2% (95%CI 0.08–18) of patients without any predictors for PTS were diagnosed with mild PTS during follow-up, and none with severe PTS, for a sensitivity of 98% (95% CI 89–100), a specificity of 14% (95% CI 10–20), a positive predictive value of 20% (95% CI 19–22), and a negative predictive value of 97% (95% CI 81–100). Conclusion: We identified 4 predictors of PTS occurring in the 2nd year after DVT. Our findings may be used to decide on whether to continue ECS treatment for an additional year, after one year of compliant ECS use, keeping in mind that patients with none of the predictors will have the lowest PTS incidence.

Venous leg ulcers (VLUs) are a major health problem because of their high prevalence and associated high cost of care. Despite the widespread use of compression, treatment recurrence rates remain high. Numerous studies have suggested that regular use of compression stockings reduces VLU recurrences. However, there are limited data concerning how long compression hosiery should be worn after ulcer healing and which class of compression hosiery achieves better results in the prevention of VLU recurrences.An open, prospective, randomized, single-center study with a 5-year follow-up was performed to establish the efficacy of two different strengths of knee-high compression hosiery (class 2 and class 3) in the prevention of VLU recurrences. The study included patients with recently healed venous ulcers and no significant arterial disease, rheumatoid disease, diabetes mellitus, and restriction in range of ankle movement. Overall, 361 patients were randomized, and 308 patients (170 men, 138 women; mean age, 59 years) completed the study. Patients were randomized into two groups: group A, 186 patients who wore a heel-less open-toed elastic class 3 compression device knitted in tubular form (Tubulcus; Laboratoires Innothera, Arcueil, France); and group B, 175 patients who wore a class 2 elastic stocking (Rudo, Nis, Serbia). All patients were instructed to wear compression stockings continuously for the first 2 years of follow-up (both during the day and at night). In the third, fourth, and fifth years of follow-up, patients were instructed to wear elastic stockings during the day only. The main outcome measures were recurrence of leg ulceration and compliance with the treatment.Rates of ulcer recurrence after the 5 years of follow-up were 28.98% for the compression class 3 group and 60% for the compression class 2 group (P .001, log-rank test). Patients in the compression class 3 group experienced significantly longer absolute (46 vs 40 months; P .001, Mann-Whitney U test) and proportional (77% vs 67%; P .001, Mann-Whitney U test) ulcer-free time after 5 years than those in the compression class 2 group. Rates of noncompliance after 5 years were 10.23% for the compression class 3 group and 6.25% for the compression class 2 group (P = .188, χThe results obtained in this study suggest that class 3 compression stockings provide a statistically significant lower recurrence rate compared with the class 2 compression stockings.

This study focuses on the improvement of dynamic properties of sand with the addition of recycled high impact polystyrene (HIPS) which is an e-waste. It is a cost-effective plastic material processed from tough polystyrene resins which have high impact resistance and dimensional stability. It has a wide application in the manufacturing of low-strength structural components, machined prototypes and computer components. Hence, it results in a large amount of e-waste after disposal. Due to its toughness and impact resistance, it can be used along with sand to improve its strength parameters. The effect on static and dynamic strength of sand for various proportions of recycled HIPS is studied. Dynamic properties like the coefficient of uniform and nonuniform elastic compression and shear values are the input parameters to predict the ground response. Those parameters were identified from the laboratory tests. The bearing capacity of reinforced and unreinforced sand was obtained from plate load tests. The cyclic plate load tests were done, and it is found that there is an increase in the values of the coefficient of uniform elastic compression and shear modulus. The dynamic properties for reinforced and unreinforced sand were obtained, analyzed, and compared.

Introduction Endogenous bioelectric fields (EBFs) play a fundamental role in promoting repair and regeneration processes, including in leg venous ulcers (LVUs). Unfortunately, the mechanism underlying the production of EBFs is easily altered by infectious, traumatic, and epigenetic factors. This alteration is one of the determining factors for the chronicity of LVUs. This study investigates how radioelectric asymmetric conveyer (REAC) technology treatments, specifically designed to optimize EBFs, and in particular tissue optimization-reparative (TO-RPR) treatment, can improve the results of standard dressing with and without elastic compression in LVU patients. Methods A total of 30 patients were enrolled (12 males and 18 females) and randomized into three groups. All patients completed the study. Group A was treated with standard dressing, elastic compression, and REAC TO-RPR treatment; Group B was treated with standard dressing and REAC TO-RPR treatment; and Group C was treated with standard dressing and elastic compression. Results The results show that the combination of REAC treatment and standard dressing associated with elastic compression has the greatest therapeutic efficacy in promoting the healing process for ulcers, reducing perceived pain, and improving the quality of life of the patients treated. Conclusions Further studies will be useful to investigate these prospective results.

No abstract available Keywords: CAS no. 68478-92-2; allergic contact dermatitis; compression stockings; patch test; platinum catalyst; platinum siloxane complex; varicose veins.

Background: Graduated elastic compression stockings are a frequently prescribed therapy for cardiovascular conditions with established benefit. However patient compliance remains low owing to significant difficulty donning the device, discomfort and poor fit. Based on end-user feedback, a novel compression device (CompressRite CR) to facilitate one handed application with minimal use of upper extremity strength was compared to Jobst stocking (Control). Methods: An open, prospective, single-center study was done in in volunteers and in-patients. Study subject’s lower extremities were clinically classified by a blinded vascular specialist. Pressure readings were obtained using a pressure sensor in standing position every 5 minutes during two 30-minute sessions using CR and Control. Results: Ninety study subjects (82 healthy volunteers, 8 in-patients, 34% males, 66% females, 70% White, 22% African American, %7 Asian, 1% Hispanic) completed the study. Clinical vascular classification revealed 31% C0, 18% C3, 16% C1, 7% C2, 4% C4 and 22% unclassified. CR performed similar to Control in terms of pressure delivery. Calf circumference was not impacted by pressure sessions in both groups. Application time of CR was higher but removal times were similar. Qualitative feedback collected showed that CR was superior to conventional garment. Conclusion: CR appeared to be equally effective to Control graduated elastic stockings with a longer application time on first attempt but consistently higher scores for satisfaction. This may represent an attractive alternative with higher patient compliance rates.

In this chapter, we turn our attention to the interfacial stability issues of graphene embedded in polymer matrix under the biaxial compression. A three-stage feature is revealed in the compressive deformation mode, including elastic compression, Euler buckling and local debonding. The failure mechanisms at the nanoscale interface are further discussed in detail.

В статье представлены результаты собственного исследования, целью которого явилась оценка эффективности системной фармакотерапии препаратами на основе диосмина 450 мг с геспередином 50 мг в сочетании с компрессионной терапией у беременных с варикозной болезнью вен нижних конечностей и варикозным расширением вен промежности. В ходе проведенной работы было выполнено комплексное клинико-лабораторное исследование у 140 беременных (95 женщин с варикозной болезнью и 45 здоровых беременных женщин) на клинической базе УО «БГМУ» (Минск, Беларусь). В результате проведенного исследования нами установлено положительное влияние предложенной схемы лечения как на субъективные проявления варикозной болезни (индекс качества жизни по опроснику CIVIQ-20 на фоне проводимого лечения составил 35,7±8,6, р=0,01), так и на лабораторные маркеры дисфункции эндотелия – уровень VEGF в сыворотке крови 24 (20–27) пг/мл vs. 26 (21–29) пг/мл, p=0,04, уровень эндотелина-1 – 5 (4,5–6) пг/мл vs. 6,5 (5–7,4) пг/мл, p=0,01. Целесообразно со 2-го триместра беременности рекомендовать прием флеботропных препаратов на основе флавоноидов в сочетании с компрессионной терапией у беременных с варикозной болезнью вен нижних конечностей класса С2а–С2s (CEAP), а также при вульварном и промежностном варикозе., The article presents the results of our own research aimed at providing that the measurement of VEGF and endothelin-1 in pregnant patients with varicose veins is essential for conservative treatment effectiveness assessment. The research included 95 pregnant women who underwent complex clinic and laboratory screening in obstetrics and gynecology department of Belarusian State Medical University (Minsk, Belarus) during 2018-2019. It was found that the concentration of VEGF and endothelin-1 increased along with disease severity in women with varicose veins.A significant fall of VEGF (26 (21–29) pg/ml vs. 24 (20–27) pg/ml, p=0.04) and endothelin-1 (6,5 (5–7,4) pg/mL vs. 5 (4,5–6) pg/mL, p=0.04) circulating was reported in women with conservative management of varicose disease including proper elastic support and pharmacotherapy. A moderate positive correlation was revealed in women with varicose veins between hs-CRP level and BMI (r=0,4, p=0,01, n=110). Conclusion: some markers of endothelial dysfunction are increased in varicose vein bloodthat may promote further progression of the disease and thrombotic complications.The management of varicose veins during pregnancy should be by conservative means and consist of proper elastic support, phlebotonics, elevation of the extremities at night and during rest periods in the day, avoiding static dependency of the legs, and control of body weight., Репродуктивное здоровье. Восточная Европа, Выпуск 3 2020

BACKGROUND: Compression bandages often are used after TKA to reduce swelling. However, the degree to which they are helpful has not been well characterized. QUESTIONS/PURPOSES: The purpose of this study was to determine whether use of a compression bandage after TKA was associated with (1) less leg swelling (our primary endpoint); or (2) secondary study endpoints, including improved ROM of flexion and extension, lower visual analog scale (VAS) pain scores for worst pain and pain during physical therapy just before surgery, postoperative day (POD) 1, POD 2, and POD 28, or fewer wound complications within 90 days of surgery. METHODS: A prospective, single-center, two-arm, parallel-group randomized controlled trial was conducted on 51 patients undergoing simultaneous, bilateral, primary TKA between February 2015 and August 2016. Patients were excluded if they had a body mass index > 40 kg/m(2), a history of a venous thromboembolic event, an allergy to the dressing or compression bandage, or lymphedema in one or both legs. Participants averaged a mean age of 62 years (range, 40-83 years). In all patients, we released the tourniquet after full wound closure, and we applied an Aquacel dressing to both limbs. Patients were randomized by opaque envelope, and the compression bandage was applied to the randomized limb. For each leg, study personnel not involved in patient care measured the patients’ limb circumference (thigh, knee, and tibia), ROM, and VAS pain scores 24 hours after surgery, 48 hours after surgery, and on POD 28. The minimal clinically important difference for circumference was 2 cm with a SD of 2 cm in the circumference. For VAS, it was 2 points with a SD of 2. For ROM, it was 10° with a SD of 15. We conservatively picked an effect size of 0.5 SD and assumed a correlation between limbs of 0.3. This set the power level at 0.80 with an α error of 0.05; thus, a power analysis for paired t-tests indicated that 45 patients would be an appropriate sample size. There were 29 patients randomized to the right leg group and 22 patients randomized to the left leg group. There were no differences between the limb with and without the compression bandage preoperatively. RESULTS: Postoperatively, there were no differences between the groups in terms of leg swelling at the thigh (POD 1: mean ± SD = 51 ± 6 with compression bandage versus mean ± SD = 51 ± 6 without compression bandage, mean Δ = - 0.14, 95% confidence interval [CI], -0.65 to 0.37], p = 0.586; POD 2: mean ± SD = 53 ± 6 with compression bandage versus mean ± SD = 53 ± 7 without compression bandage, mean Δ = -0.22, 95% CI, -0.95 to 0.51, p = 0.548; POD 28: mean ± SD = 47 ± 6 with compression bandage versus mean ± SD = 47 ± 6 without compression bandage, mean Δ = -0.01, 95% CI, -0.39 to 0.38, p = 0.975), knee (POD 1: mean ± SD = 45 ± 4 with compression bandage versus mean ± SD = 45 ± 5 without compression bandage, mean Δ = -0.44, 95% CI, -1.16 to 0.28, p = 0.223; POD 2: mean ± SD = 46 ± 4 with compression bandage versus mean ± SD = 46 ± 4 without compression bandage, mean Δ = -0.30, 95% CI, -0.69 to 0.10, p = 0.137; POD 28: mean ± SD = 42 ± 5 with compression bandage versus mean ± SD = 42 ± 5 without compression bandage, mean Δ = 0.21, 95% CI, -0.34 to 0.76, p = 0.446), and shin (POD 1: mean ± SD = 40 ± 4 with compression bandage versus mean ± SD = 40 ± 4 without compression bandage, mean Δ = -0.22, 95% CI, -1.23 to 0.79, p = 0.659; POD 2: mean ± SD = 41 ± 4 with compression bandage versus mean ± SD = 41 ± 4 without compression bandage, mean Δ = -0.31, 95% CI, -0.72 to 0.09, p = 0.126; POD 28: mean ± SD = 37 ± 4 with compression bandage versus mean ± SD = 37 ± 4 without compression bandage, mean Δ = -0.34, 95% CI, -0.92 to 0.24, p = 0.246). There were no differences between the groups in terms of flexion ROM (POD 1: mean ± SD = 56 ± 25 with compression bandage versus mean ± SD = 58 ± 22 without compression bandage, mean Δ = -2.63, p = 0.234; POD 2: mean ± SD = 64 ± 20 with compression bandage versus mean ± SD = 63 ± 23 without compression bandage, mean Δ = 1.22, p = 0.534; POD 28: mean ± SD = 101 ± 20 with compression bandage versus mean ± SD = 102 ± 20 without compression bandage, mean Δ = -1.64, p = 0.103) and extension (POD 1: mean ± SD = 12 ± 7 with compression bandage versus mean ± SD = 12 ± 7 without compression bandage, mean Δ = 0.51, p = 0.328; POD 2: mean ± SD = 9 ± 5 with compression bandage versus mean ± SD = 10 ± 6 without compression bandage, mean Δ = -1.28, p = 0.061; POD 28: mean ± SD = 6 ± 14 with compression bandage versus mean ± SD = 4 ± 4 without compression bandage, mean Δ = 2.19, p = 0.252). With the numbers available, we observed greater maximal postoperative pain for the limb with the compression bandage than the control limb on POD 1 and POD 2, but not on POD 28 (POD 1: mean ± SD = 8 ± 3 with compression bandage versus mean ± SD = 7 ± 3 without compression bandage, mean Δ = 0.66, p = 0.030; POD 2: mean ± SD = 7 ± 2 with compression bandage versus mean ± SD = 7 ± 3 without compression bandage, mean Δ = 0.80, p = 0.008; POD 28: mean ± SD = 4 ± 3 with compression bandage versus mean ± SD = 3 ± 3 without compression bandage, mean Δ = 0.14, p = 0.526). Likewise, there was greater pain during physical therapy for the limb with the compression bandage than the limb without on POD 2, but not on POD 1 and POD 28 (POD 1: mean ± SD = 7 ± 3 with compression bandage versus mean ± SD = 6 ± 3 without compression bandage, mean Δ = 0.29, p = 0.460; POD 2: mean ± SD = 8 ± 2 with compression bandage versus mean ± SD = 7 ± 3 without compression bandage, mean Δ = 0.67, p = 0.018; POD 28: mean ± SD = 5 ± 2 with compression bandage versus mean ± SD = 5 ± 3 without compression bandage, mean Δ = 0.14, p = 0.600). With the numbers available, we observed no difference in 90-day wound healing complications between the limb with and the limb without the compression dressing; however, the sample size was too small to analyze this in a meaningful statistical way. Overall, there were 6% total wound complications in the compression bandage group and 12% total wound complications in the group without the compression bandage (odds ratio [OR], 0.47; p = 0.487). Drainage was not observed in the group with the compression bandage, whereas the group without the compression bandage had 6% drainage (OR, 0.00; p = 0.243). There were no deep infections or reoperations within 90 days postoperatively. CONCLUSIONS: Applying a compression bandage after TKA did not result in any clinical improvement in limb circumference, ROM, or pain. Based on this study, we believe that applying a compression bandage after TKA neither benefits nor harms the patient. Thus, we no longer use compression dressings for routine primary TKA. LEVEL OF EVIDENCE: Level I, therapeutic study.

Compression garments are extensively used for various therapeutic treatments and are expected to deliver accurate and reproducible compression pressures. This study focuses on developing an analytical model to predict the pressure generation by compression garments on human limb analogues. The analogues consisted of non-compressible and compressible cylinders that were chosen as the first step towards evaluating pressure generation on real human limbs. An experimental platform was developed to quantify the relationship between material properties, initial garment extension and pressure. A mathematical model was presented that provided greater accuracy in predicting the pressure generated by compression garments than the existing Young-Laplace equation for compressible limb analogues.

Introduction: Elastic compression stockings (ECS) are commonly used for the prevention of post-thrombotic syndrome (PTS) after deep venous thrombosis (DVT). However, their efficacy is controversial. While two open-label studies reported a 50% risk reduction of PTS in the ECS vs. no-ECS groups, a large double-blind study didn't find any benefit of ECS vs. placebo-ECS to prevent PTS. These opposite results could be explained either by a placebo effect in the open-label studies or to a lack of compliance to study ECS in the double-blind study. Additional data on the impact of compliance on ECS efficacy, obtained in a double-blind way, are therefore needed. Methods: We analyzed data from the French, CELEST, multicentre double-blind trial comparing 25mmHg ECS vs. 35mmHg ECS to prevent PTS at 2 years after a first symptomatic ipsilateral proximal DVT (NCT01578122). All CELEST patients who had complete data for primary outcome (i.e. PTS, defined as a Villalta score ≥5 on the DVT affected leg at the one- or 2-year follow up visit) were included. The objectives of this predefined analysis were to: i) compare the incidences of PTS at 2 years according to compliance to ECS (irrespective of allocated treatment group) during the first 3 months of treatment and during the 2-year follow-up; ii) assess independent predictors of PTS using a stepwise multivariable model including all of the following variables (baseline patients' and DVT characteristics, anticoagulant treatment and compliance to ECS) if they achieved a p value of 0.2 or less in univariate analysis as well as ECS strength allocation group; iii) build an induction tree algorithm to measure the impact in terms of incidence of PTS of each of the independent predictor of PTS. Compliance to ECS was defined as reasonable and optimal if the patient had worn the study ECS more than 50% and more than 80% of the time respectively and had a modified GIRERD score of 0-2. Results: 249 patients were eligible for this analysis. Mean baseline age was 57 years, 70% (n=174) were men, 20% (n=50) were obese, 21% (n=52) had previous VTE event, 7% (n=18) had a baseline Villalta score ≥5 and the most proximal extent of DVT was the iliac vein in 15% (n=37) of cases. In 80% (n=179) of cases patients were treated with anticoagulation for more than 6 months after DVT and a direct oral anticoagulant (DOAC) was used in 69% (n=164) of cases. 32 % (n=80) of patients developed PTS at 2 years. When patients wore study ECS>80% of the time (i.e optimal compliance), incidence of PTS over 2 years was 26.1% (n=31). Incidence of PTS was 25.0% (n=10) and 40.5% (n=34) in those patients who wore ECS 50-80% and Conclusions: In our double bling study assessing 25mmHg vs. 35mmHg ECS to prevent PTS, compliance to ECS was a significant independent predictor of PTS in our multivariable model. Impact of ECS use became apparent when patient used ECS at least 50% of the time without any strong benefit beyond. Wearing study ECS>50% of the time was associated with 2-fold decreased risk of developing PTS, which is consistent with the results from previous 'positive' open-label studies. It suggests that use of ECS influences the risk of developing PTS. Our induction tree algorithm evidences that being compliant with ECS seems particularly beneficial in - non-obese - patients with extensive DVT. Figure 1 Figure 1. Disclosures Verriere: Laboratoires Innothera: Current Employment.

Objective. The aim of the work is to improve the results of complex conservative treatment of elderly and senile patients with trophic ulcers of the lower extremities on the background of chronic venous, cardiovascular insufficiency and type II diabetes mellitus with the use of adjuvant general and local pharmacotherapy in a general practice and family medicine outpatient setting. Materials and methods. The paper presents ten years of conservative treatment 834 patients (of them: in working age – 209, in the elderly and senile – 625), the trophic ulcers of the lower limbs and other venous etiology in a district hospitals (2007-2012) and in ambulatory general practice and family medicine (2013-2016), using a common adjuvant treatment Oregon protocol based (1999) and locally – ointment medical dressings, including Unna's boot, carefully principle of motion phases of wound healing, and the use of medical daily elastic compression. Result. Ulcers with a diameter of 2 to 5cm (344) treatment to complete epithelialization was between 2 to 5 weeks; and ulcers in diameter from 6 to 9 cm (179), he was 6-10 weeks. Thus, in 31 patients healing took place under the bandage Unna's boot and in 59 patients with ulcers with a diameter of 10 cm treatment periods were 15-18 weeks, with repeated use of Unna's boot. In 44 (7 %) treated patients with recurrent ulcers occurring due to violation of compression therapy. Conclusion. Thus, the use of above mentioned treatment, taking into account current phases of wound healing, and medical daily elastic compression makes it possible to get a 93 % sustained therapeutic effect.

The influence of directional elastic compression deformation on the electrophysical properties of p -type germanium single crystals was investigated. The dependences of the Hall coefficient on the magnetic field strength on samples of different crystallographic orientations in the absence and in the presence of uniaxial mechanical stress were measured at two temperatures (room temperature and liquid nitrogen temperature). On the same samples, the tensoresistance and longitudinal tensomagnetoresistance were studied in a wide range of mechanical stresses ( 0 ≤ X ≤ 1 GPa ). The presence of anisotropy of galvanomagnetic effects in p -Ge was revealed both in the absence of deformation and under very strong mechanical loads. Experiments on measuring the longitudinal tensomagnetoresistance make it possible to conclude that the isoenergetic surfaces in p -Ge, which arise as a result of directional elastic compression deformation, cannot be considered as perfect ellipsoids of revolution, at least in the investigated X range.

At present, the technology of strengthening bridge with prestressed CFRP bars is gradually rising, so it is necessary to study the law of prestress loss. In order to evaluate the short-term prestress loss of prestressed carbon fiber reinforced (CFRP) bars, the prestress loss of CFRP bars used for reinforcement of reinforced concrete beams was studied by combining laboratory tests with practical reinforcement projects. The anchorage loss, concrete elastic compression loss of CFRP bars were obtained by measuring the prestressed loss data of CFRP bars used to strengthen retired old beams and corresponding theoretical calculation. Then, combined with the corresponding loss data of 6 prestressed CFRP bars in the actual strengthening project of Wenzhou Lijing Middle Bridge, the experimental investigation was carried out. The results show that the prestress loss of CFRP bars is between 4%∼8%, and develops rapidly in the early stage, among which the anchorage loss accounts for 45.90%. The anchorage retraction value is about 1.33mm, and the elastic compression loss of concrete is basically negligible.