1. COVID-19-related diffuse leukoencephalopathy with microbleeds and persistent coma: a case report with good clinical outcome
- Author
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Elbert Hans Witvoet, Feng Yan Jiang, Willemijn Laumans, and Sebastiaan Franciscus Titus Maria de Bruijn
- Subjects
Male ,medicine.medical_specialty ,Poor prognosis ,Coronavirus disease 2019 (COVID-19) ,Sedation ,Case Report ,Leukoencephalopathy ,Leukoencephalopathies ,medicine ,Humans ,Glasgow Coma Scale ,Coma ,Cerebral Hemorrhage ,Respiratory distress ,business.industry ,SARS-CoV-2 ,COVID-19 ,General Medicine ,Middle Aged ,coma and raised intracranial pressure ,medicine.disease ,Diffuse leukoencephalopathy ,Radiology ,medicine.symptom ,business - Abstract
A 60-year-old patient presented with respiratory distress, after recently being tested COVID-19 positive and was mechanically ventilated for 15 days. After cessation of sedation, he remained in deep comatose state, without any reaction on pain stimuli (Glasgow Coma Score 3). MRI of the brain showed diffuse leukoencephalopathy and multiple (>50) microbleeds. Diffuse COVID-19-associated leukoencephalopathy with microhaemorrhages is associated with a poor prognosis. However, 3 months later, our patient showed a remarkable recovery and was able to walk independently. This case report shows COVID-related leukoencephalopathy and intracerebral microbleeds, even with persistent comatose state, may have a favourable clinical outcome and prolonged treatment should be considered in individual cases.
- Published
- 2021