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Interventional Cardiac Electrophysiology is the first and only comprehensive, state-of-the-art textbook written for practitioners in multiple specialties involved in the care of the arrhythmia patient. Encompassing the entire field of interventional therapy for cardiac rhythm management, from basic science to evidence-based medicine to future directions, topics include: • Technology and Therapeutic Techniques – EP techniques; imaging and radiologic technology; device and ablation technology; drug therapy. • Interventional Electrophysiologic Procedures – Diagnostic and physiologic EP techniques; mapping in percutaneous catheter and surgical EP procedures; catheter and surgical ablation; device implantation and management. • Clinical Indications and Evidence-based Outcomes Standards – For medical and surgical EP interventions for arrhythmias. • New Directions in Interventional Electrophysiology – Hybrid therapy for atrial and ventricular arrhythmias and staged therapy. This book will be essential reading for clinicians and researchers that form the health care team for arrhythmia patients: cardiologists, adult and pediatric clinical electrophysiologists, interventional electrophysiologists, cardiac surgeons practicing arrhythmia surgery, allied health care professionals, pharmacologists, radiologists and anesthesiologists evaluating arrhythmia patients, and basic scientists from the biomedical engineering and experimental physiology disciplines. Professor Sanjeev Saksena has been involved in this arena for over three decades and has brought his experience to this textbook, assembling editorial leadership from medical and surgical cardiology to provide a global perspective on fundamentals of medical practice, evidence-based therapeutic practices, and emerging research in this field.

Mayo Clinic Electrophysiology Manual is the first comprehensive guide to the electrical activity of biological cells and tissues and the techniques of electrophysiology. Through a case-based discussion of patients with arrhythmias, the book illustrates the various contemporary techniques for diagnosis, imaging, and physiology-based therapeutic ablation. Section One addresses the basics of electrophysiology, including device placement, recording, measurement, diagnosis, imaging, amperometry, and physiology-based therapeutic ablation, helping the reader appreciate and more fully understand the complexity and lessons of the emergent specialty. The second section is a case-based discussion of adult and pediatric arrhythmias broken down into twenty patient case studies intended to help the student and clinician apply their understanding of electrophysiology to real presentations, and think about how to plan and execute invasive study and ablation. Each of the twenty case chapters features a question and answer section in order to aid study and retention of material. Replete with full-page color images of intracardiac electrograms, fluoroscopic images, ultrasound images, advanced mapping, and correlated anatomic dissection, Mayo Clinic Electrophysiology Manual is the first focused exploration of the topic and is specifically designed to help both students and practitioners understand and integrate techniques into their daily practice. At present, clinicians have to piece together information on electrophysiology from a variety of sources, often leaving gaps in knowledge. Mayo Clinic Electrophysiology Manual provides the clinician with a single authoritative guide and quick reference. Through in-depth analysis of electrophysiological techniques and an understanding of the anatomic and physiological basis for present day mapping, image integration, and ablation, this volume is an indispensable resource for students, practicing physicians, researchers, and experts in electrophysiology. Includes 12 months of free online access with purchase.

In little less than a decade brain slices have gained prominence among neurobiologists as appropriate tools to study cellular electrophysiolog­ ical aspects of mammalian brain function. The purpose of this volume is to present in some detail several inquiries in the brain sciences that have benefited greatly by the use of brain slices. The book is directed primarily toward advanced students and researchers wishing to evaluate the impact these in vitro preparations of the mammalian brain are having on neurobiology. The term brain slice has come to refer to thin (100-700 j. Lm) sections of a brain region prepared from adult mammals and maintained for many hours in vitro, for either electrophysiological or biochemical stud­ ies. In addition to good accessibility, slices feature relatively intact syn­ aptic connections that allow a variety of experiments not feasible with standard in vivo or tissue culture preparations. Certain electrophysiol­ ogical studies once practical only with invertebrate models are becoming routine with mammalian brain slices. The ability to perform both bio­ chemical and electro physiological experiments on the same piece of CNS tissue provides additional bright prospects for future research. Although most of the electrophysiological studies have dealt with hippocampal slices, it should be evident from this book that slice methodology is not limited to the hippocampus. The Appendix,'Brain Slice Methods,'is a multiauthored treatment of the technical aspects of brain slice work, collected into one document.

Electrophysiological Methods in Biological Research, Third Revised Edition describes the principles and applications of significant electrophysiological methods as regards to transistorisation of electrophysiological apparatus and to the mathematical analysis of electrophysiological data. The book explains the aspects of physics and electronics that are important in electrophysiology, such as the basic principles of semiconductor function, electronic simulators, electrodes, and the processing of electrophysiological data. The text also cites several examples that measure the resulting membrane potential if one electrode is inside the cell while the other is in contact with the cell's surface. Other experiments show the electrophysiological techniques and the fundamentals of electrical activity in the peripheral excitable structures, and its association with physiological functions. In considering the problems of nerve and muscle physiology, the investigator should know the technique of recording the electrical signs of a nerve impulse. These signs, or action potentials, indicate the presence of a nerve impulse. The text also discusses the effects of barbiturates or ether anesthesia in EEG activity, as well as its dissociation after physostigmine and atropine have been administered. The book can prove useful for pharmacologists, microchemists, cellular biologists, and research workers and technologists dealing with neural mechanisms.