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Social anxiety is one of the most common psychological disorders along with depression and generalized anxiety. Avoiding eye contact, persistent fear of being judged and negatively evaluated by others, and social isolation are just some of the specific features of this type of anxiety.As part of the complex oral rehabilitation treatment, we also faced such a case which involved a lot of attention and time, but to which was also added the joint and muscle pathology, superposing with the social the dental treatments anxiety , the patient needing a special complex treatment approach.

Nowadays, infection diseases are one of the most significant threats to humans all around the world. An encouraging strategy for solving this issue and fighting resistant microorganisms is to develop drug carriers for a prolonged release of the antibiotic to the target site. The purpose of this work was to obtain metronidazole-encapsulated chitosan nanoparticles using an ion gelation route and to evaluate their properties. Due to the advantages of the ionic gelation method, the synthesized polymeric nanoparticles can be applied in various fields, especially pharmaceutical and medical. Loading capacity and encapsulation efficiency varFied depending on the amount of antibiotic in each formulation. Physicochemical characterization using scanning electron microscopy revealed a narrow particle size distribution where 90% of chitosan particles were 163.7 nm in size and chitosan-loaded metronidazole nanoparticles were 201.3 nm in size, with a zeta potential value of 36.5 mV. IR spectra revealed characteristic peaks of the drug and polymer nanoparticles. Cell viability assessment revealed that samples have no significant impact on tested cells. Release analysis showed that metronidazole was released from the chitosan matrix for 24 h in a prolonged course, implying that antibiotic-encapsulated polymer nanostructures are a promising drug delivery system to prevent or to treat various diseases. It is desirable to obtain new formulations based on drugs encapsulated in nanoparticles through different preparation methods, with reduced cytotoxic potential, in order to improve the therapeutic effect through sustained and prolonged release mechanisms of the drug correlated with the reduction of adverse effects.

Knee osteoarthritis (KOA) is a chronic multifactorial pathology and a current and essential challenge for public health, with a negative impact on the geriatric patient’s quality of life. The pathophysiology is not fully known; therefore, no specific treatment has been found to date. The increase in the number of newly diagnosed cases of KOA is worrying, and it is essential to reduce the risk factors and detect those with a protective role in this context. The destructive effects of free radicals consist of the acceleration of chondrosenescence and apoptosis. Among other risk factors, the influence of redox imbalance on the homeostasis of the osteoarticular system is highlighted. The evolution of KOA can be correlated with oxidative stress markers or antioxidant status. These factors reveal the importance of maintaining a redox balance for the joints and the whole body’s health, emphasizing the importance of an individualized therapeutic approach based on antioxidant effects. This paper aims to present an updated picture of the implications of reactive oxygen species (ROS) in KOA from pathophysiological and biochemical perspectives, focusing on antioxidant systems that could establish the premises for appropriate treatment to restore the redox balance and improve the condition of patients with KOA.

In the current economic situation statistical indicators suggest a decline in global and national dental services market under increased competition. So we must take a cost-effective and strengthening market position. Thus it is recommended that the management office to focus on retention and follow active patients and a system of quality control of treatments. In order to achieve these objectives must monitor certain type of control elements medical, economic, management and promotion.

Although obesity and a sedentary lifestyle are well-known risk factors for type 2 diabetes, at molecular level, the oxidative stress is regarded as the primary contributor to the pathogenic process. Our work intends to evidence how the thinking models influence the way that medical practitioners understand the pathogenic mechanisms. Some research groups focused lately on the system’s dynamics and Complex Systems Theory. The living organisms as a complex system could be analyzed applying the network concept. Alternative methods for characterizing biological processes or phenomena based on feedback node structure have been developed [1].

The treatment with partially removable prostheses has become more and more complex over time, especially in the last few decades. And when it is planned correctly, and executed responsibly, it will actually help preserve the remaining dental units. Consequently, performing the treatment in a defective manner, can trigger the resorption of the bone support and can accelerate the degradation of the remaining units, resulting in their loss.Elastic prostheses are the most modern alternative to injectable acrylic prostheses. The material is elastic, with a thinner thickness than conventional prostheses, resistant to pressure and dynamic movements during chewing, and very well approved from a biocompatible point of view by the tissues of the oral cavity. The reasons for choosing to treat partial edentulousness with partially removable elastic prosthesis are the feasibility and reliability of this.

Aim of the study was to identify the degree of satisfaction of patients about quality of the private dental medicine practices from Iasi, Romania. Material and methods. The authors of this study tested a representative sample of the population, consisting of 144 people, with different professions and ages. The data collection tool was an original questionnaire. Through its administration, it was intended to assess the patient’s satisfaction with the dental care they received in different dental offices in Iasi during year 2018. Results. The results of the study show that 74.31% of the total patients surveyed are satisfied with the clinical quality of the dental care received, and 18.06% of them are worried about the high prices. The questioned patients believe that dentists with private practice have the necessary equipment and materials to provide dental services at the proper quality. Conclusions. Our study offers useful information for quality management of dental medicine services provided to the local population.

Aim of the study was to identify the prevalence of patient anxiety before treatment and to determine patients’ perception of the dental treatment risks. Material and methods. The cross-sectional study was conducted in 210 patients (69 males and 141 females) aged 11-70 years in northeastern Romania, who completed Corah’s Dental Anxiety Scale, Revised (DAS-R), Modified Dental Anxiety Scale (MDAS) and Dental Concerns Assessment, Revised (DCA-R). Results. The overall scores of DAS-R indicated high anxiety in 4.3% of patients and severe anxiety or phobia in 2.9% of patients. Overall scores of the MDAS questionnaire indicated 5.2% of very anxious patients and 2.3% of highly anxious or phobic patients with dental treatments. DCA-R indicated high anxiety for injection and extraction. We found statistically significant differences between anxiety levels and age ranges as well as patients’ environmental areas (p