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Your search keyword '"Elgammal, Suzanne"' showing total 24 results
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24 results on '"Elgammal, Suzanne"'

5. Wire- and radiofrequency identification tag-guided localization of impalpable breast lesions: iBRA-NET localization study.

Author

Harvey, James, Morgan, Jenna, Lowes, Simon, Milligan, Robert, Barrett, Emma, Carmichael, Amtul, Elgammal, Suzanne, Masudi, Tahir, Holcombe, Chris, Masannat, Yazan, Potter, Shelley, Dave, Rajiv V, Al Numani, H, Kastora, S, Simpson, L, Lynch, R, Kleidi, E, Wignarajah, P, Johnson, L, and Ledwidge, S

Subjects
RADIO frequency
Abstract

A national cohort ideal stage 2a/2b study comparing the safety and effectiveness of Wire- and RFID -guided localisation for impalpable breast lesions. [ABSTRACT FROM AUTHOR]

Published
2024
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7. 07. The iBRANET localisation study; A National cohort study of wire-guided and Magseed-guided localisation for impalpable breast lesions

Author

Dave, Rajiv, primary, Elgammal, Suzanne, additional, Barrett, Emma, additional, Barnes, Nicola, additional, Sami, Amtul, additional, Masudi, Tahir, additional, Down, Sue, additional, Holcombe, Chris, additional, Potter, Shelley, additional, Somasundaram, Santosh K., additional, Gardiner, Matthew D., additional, Maxwell, Anthony J., additional, Mylvaganam, Senthurun, additional, and Harvey, James, additional

Published
2021
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8. A Novel Mixed-Methods Platform Study Protocol for Investigating New Surgical Devices, with Embedded Shared Learning: Ibra-net Breast Lesion Localisation Study

Author

Bromley, Hannah L., primary, Dave, Rajiv, additional, Holcombe, Chris, additional, Potter, Shelley, additional, Maxwell, Anthony J., additional, Kirwan, Cliona, additional, Mylvaganam, Senthurun, additional, Elgammal, Suzanne, additional, Morgan, Jenna, additional, Down, Sue, additional, Masudi, Tahir, additional, Sami, Amtul, additional, Barnes, Nicola, additional, and Harvey, James, additional

Published
2021
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9. Wire- and magnetic-seed-guided localization of impalpable breast lesions: iBRA-NET localisation study.

Author

Dave, Rajiv V., Barrett, Emma, Morgan, Jenna, Chandarana, Mihir, Elgammal, Suzanne, Barnes, Nicola, Sami, Amtul, Masudi, Tahir, Down, Sue, Holcombe, Chris, Potter, Shelley, Somasundaram, Santosh K., Gardiner, Matthew, Mylvaganam, Senthurun, Maxwell, Anthony, and Harvey, James

Subjects
LUMPECTOMY, SURGICAL excision, SEED technology, REOPERATION
Abstract

Background: Wire localization is historically the most common method for guiding excision of non-palpable breast lesions, but there are limitations to the technique. Newer technologies such as magnetic seeds may allow some of these challenges to be overcome. The aim was to compare safety and effectiveness of wire and magnetic seed localization techniques. Methods: Women undergoing standard wire or magnetic seed localization for non-palpable lesions between August 2018 and August 2020 were recruited prospectively to this IDEAL stage 2a/2b platform cohort study. The primary outcome was effectiveness defined as accurate localization and removal of the index lesion. Secondary endpoints included safety, specimen weight and reoperation rate for positive margins. Results: Data were accrued from 2300 patients in 35 units; 2116 having unifocal, unilateral breast lesion localization. Identification of the index lesion in magnetic-seed-guided (946 patients) and wire-guided excisions (1170 patients) was 99.8 versus 99.1 per cent (P= 0.048). There was no difference in overall complication rate. For a subset of patients having a single lumpectomy only for lesions less than 50mm (1746 patients), there was no difference in median closest margin (2mm versus 2 mm, P=0.342), re-excision rate (12 versus 13 per cent, P=0.574) and specimen weight in relation to lesion size (0.15 g/mm² versus 0.138 g/mm2, P=0.453). Conclusion: Magnetic seed localization demonstrated similar safety and effectiveness to those of wire localization. This study has established a robust platform for the comparative evaluation of new localization devices. [ABSTRACT FROM AUTHOR]

Published
2022
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12. 11. THE IBRANET LOCALISATION STUDY; A NATIONAL MULTI-CENTRE PROSPECTIVE COHORT STUDY OF WIRE- AND MAGSEED-GUIDED LOCALISATION FOR IMPALPABLE BREAST LESIONS

Author

Dave, Rajiv, primary, Barnes, Nicola, additional, Sami, Amtul, additional, Masudi, Tahir, additional, Down, Sue, additional, Mylvaganam, Seni, additional, Somasundaram, Santosh, additional, Gardiner, Mathew, additional, Maxwell, Anthony, additional, Potter, Shelley, additional, Holcombe, Chris, additional, Harvey, James, additional, and Elgammal, Suzanne, additional

Published
2020
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13. 29. The MagSeed® Experience: One Year On

Author

Reid, Judith, primary, Tovey, Sian, additional, Campbell, E.J., additional, Pareek, Sujata, additional, Kelly, Jacqueline, additional, Law, Penny, additional, Coldeway, Jon, additional, Mumba, Evaristo, additional, and Elgammal, Suzanne, additional

Published
2019
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15. Exploration of factors affecting severity in acute pancreatitis

Author

Elgammal, Suzanne

Subjects
Medicine, pancreatitis
Abstract

Acute Pancreatitis (AP) is associated with a significant mortality despite advances in critical care and surgical management of the disease. A significant subgroup of patients with AP will have complications including Multiple Organ Dysfunction Syndrome (MODS) and Infected Pancreatic Necrosis (IPN) which are associated with higher mortality rates. The pathophysiology of MODS is not yet fully understood but cytokines are known to play a role. Three factors influencing mortality in patients with acute pancreatitis have been identified. Firstly, the host response to acute inflammation, which determines the pattern of cytokine response and may be subject to genetic control. Secondly, the development of infected pancreatic necrosis and the influence of surgical strategies developed to deal with this. Thirdly, the nature of infecting organisms in patients with IPN. Aims The aims of this thesis are 1) To compare genetic polymorphisms in an interleukin-8 locus in a cohort of patients with AP and healthy controls with regard to severity and susceptibility 2) To examine a retrospective series of patients with infected pancreatic necrosis and compare open and percutaneous necrosectomy techniques with regard to organ dysfunction and mortality 3) To identify microbiological factors which may affect outcome in patients with infected pancreatic necrosis 1) Materials and Methods Previously collected DNA samples from 106 patients with predicted severe AP were subjected to sequence specific PCR of 6 Interleukin-8 single nucleotide polymorphisms (SNPs) and compared with 100 healthy control DNA samples. SNP frequencies were compared in patients with mild and severe disease and between patients and controls. Patients and Methods 2) Ninety-nine patients with infected pancreatic necrosis treated surgically at GRI between December 1989 and March 2002 were prospectively identified. Retrospective case note review was performed. Patients were divided into OPEN and PERC (percutaneous) groups for analysis. Outcome measures included mortality and ITU requirements. 3) The same IPN cohort was further analysed with respect to microbial spectrum, use of prophylactic antibiotics, development of resistant organisms and effect on mortality. Results 1) No differences in Interleukin-8 SNP frequencies were noted between mild and severe patients or between patients and controls. 2) Fifty-six and 49 patients underwent open and percutaneous pancreatic necrosectomy respectively. Mortality rates were similar in both groups. Significantly fewer patients in the PERC group required ICU post-operatively indicating a reduction in post-operative MODS. 3) The spectrum of microbial infection varied slightly over the study period. Prophylactic antibiotic usage has been avoided latterly in this unit but overall prophylactic antibiotic use has not changed significantly. Fungal infection was associated with higher mortality rates. Conclusions Several factors affecting severity have been identified in Acute Pancreatitis. From this work, it has been demonstrated that: 1) Six hiterleukin-8 polymorpliisms do not seem to be related to disease severity or susceptibility in a cohort of AP patients 2) Minimally invasive pancreatic necrosectomy reduces post-operative MODS in patients with IPN and may improve mortality with continued improvements in technique. 3) Fungal infection is associated with higher mortality rates in patients with IPN.

Published
2008

22. Exploration of factors affecting severity in acute pancreatitis

Author

Elgammal, Suzanne and Elgammal, Suzanne

Abstract

Acute Pancreatitis (AP) is associated with a significant mortality despite advances in critical care and surgical management of the disease. A significant subgroup of patients with AP will have complications including Multiple Organ Dysfunction Syndrome (MODS) and Infected Pancreatic Necrosis (IPN) which are associated with higher mortality rates. The pathophysiology of MODS is not yet fully understood but cytokines are known to play a role. Three factors influencing mortality in patients with acute pancreatitis have been identified. Firstly, the host response to acute inflammation, which determines the pattern of cytokine response and may be subject to genetic control. Secondly, the development of infected pancreatic necrosis and the influence of surgical strategies developed to deal with this. Thirdly, the nature of infecting organisms in patients with IPN. Aims The aims of this thesis are 1) To compare genetic polymorphisms in an interleukin-8 locus in a cohort of patients with AP and healthy controls with regard to severity and susceptibility 2) To examine a retrospective series of patients with infected pancreatic necrosis and compare open and percutaneous necrosectomy techniques with regard to organ dysfunction and mortality 3) To identify microbiological factors which may affect outcome in patients with infected pancreatic necrosis 1) Materials and Methods Previously collected DNA samples from 106 patients with predicted severe AP were subjected to sequence specific PCR of 6 Interleukin-8 single nucleotide polymorphisms (SNPs) and compared with 100 healthy control DNA samples. SNP frequencies were compared in patients with mild and severe disease and between patients and controls. Patients and Methods 2) Ninety-nine patients with infected pancreatic necrosis treated surgically at GRI between December 1989 and March 2002 were prospectively identified. Retrospective case note review was performed. Patients were divided into OPEN and PERC (percutaneous) groups f

23. Exploration of factors affecting severity in acute pancreatitis

Author

Elgammal, Suzanne and Elgammal, Suzanne

Abstract

Acute Pancreatitis (AP) is associated with a significant mortality despite advances in critical care and surgical management of the disease. A significant subgroup of patients with AP will have complications including Multiple Organ Dysfunction Syndrome (MODS) and Infected Pancreatic Necrosis (IPN) which are associated with higher mortality rates. The pathophysiology of MODS is not yet fully understood but cytokines are known to play a role. Three factors influencing mortality in patients with acute pancreatitis have been identified. Firstly, the host response to acute inflammation, which determines the pattern of cytokine response and may be subject to genetic control. Secondly, the development of infected pancreatic necrosis and the influence of surgical strategies developed to deal with this. Thirdly, the nature of infecting organisms in patients with IPN. Aims The aims of this thesis are 1) To compare genetic polymorphisms in an interleukin-8 locus in a cohort of patients with AP and healthy controls with regard to severity and susceptibility 2) To examine a retrospective series of patients with infected pancreatic necrosis and compare open and percutaneous necrosectomy techniques with regard to organ dysfunction and mortality 3) To identify microbiological factors which may affect outcome in patients with infected pancreatic necrosis 1) Materials and Methods Previously collected DNA samples from 106 patients with predicted severe AP were subjected to sequence specific PCR of 6 Interleukin-8 single nucleotide polymorphisms (SNPs) and compared with 100 healthy control DNA samples. SNP frequencies were compared in patients with mild and severe disease and between patients and controls. Patients and Methods 2) Ninety-nine patients with infected pancreatic necrosis treated surgically at GRI between December 1989 and March 2002 were prospectively identified. Retrospective case note review was performed. Patients were divided into OPEN and PERC (percutaneous) groups f

24. Exploration of factors affecting severity in acute pancreatitis

Author

Elgammal, Suzanne and Elgammal, Suzanne

Abstract

Acute Pancreatitis (AP) is associated with a significant mortality despite advances in critical care and surgical management of the disease. A significant subgroup of patients with AP will have complications including Multiple Organ Dysfunction Syndrome (MODS) and Infected Pancreatic Necrosis (IPN) which are associated with higher mortality rates. The pathophysiology of MODS is not yet fully understood but cytokines are known to play a role. Three factors influencing mortality in patients with acute pancreatitis have been identified. Firstly, the host response to acute inflammation, which determines the pattern of cytokine response and may be subject to genetic control. Secondly, the development of infected pancreatic necrosis and the influence of surgical strategies developed to deal with this. Thirdly, the nature of infecting organisms in patients with IPN. Aims The aims of this thesis are 1) To compare genetic polymorphisms in an interleukin-8 locus in a cohort of patients with AP and healthy controls with regard to severity and susceptibility 2) To examine a retrospective series of patients with infected pancreatic necrosis and compare open and percutaneous necrosectomy techniques with regard to organ dysfunction and mortality 3) To identify microbiological factors which may affect outcome in patients with infected pancreatic necrosis 1) Materials and Methods Previously collected DNA samples from 106 patients with predicted severe AP were subjected to sequence specific PCR of 6 Interleukin-8 single nucleotide polymorphisms (SNPs) and compared with 100 healthy control DNA samples. SNP frequencies were compared in patients with mild and severe disease and between patients and controls. Patients and Methods 2) Ninety-nine patients with infected pancreatic necrosis treated surgically at GRI between December 1989 and March 2002 were prospectively identified. Retrospective case note review was performed. Patients were divided into OPEN and PERC (percutaneous) groups f

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