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496 results on '"Elger C.E."'

2. Autoren

Author

Andresen, V., primary, Bingel, U., additional, Brandt, T., additional, Brassel, F., additional, Daniels, C., additional, Deuschl, G., additional, Diener, H.-C., additional, Eckstein, H.-H., additional, Elger, C.E., additional, Eyüpoglu, I., additional, Faissner, S., additional, Forsting, M., additional, Gold, R., additional, Heuß, D., additional, Hopf, H.C., additional, Jeup, M., additional, Jordan, B., additional, Kastrup, O., additional, Klein, M., additional, Kleine-Borgmann, J., additional, Kovac, S., additional, Kuramatsu, J.B., additional, Layer, P., additional, Limmroth, V., additional, Nacimiento, W., additional, Nickenig, G., additional, Pfister, H.-W., additional, Schipper, J., additional, Schneider-Gold, C., additional, Scholz, M., additional, Sommer, C.-M., additional, Strupp, M., additional, Sure, U., additional, Toyka, K.V., additional, von Schassen, K.H., additional, Wallesch, C.-W., additional, and Zierz, S., additional

Published
2021
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3. Epilepsien

Author

Elger, C.E., primary, Jeub, M., additional, and Kovac, S., additional

Published
2021
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5. Epilepsien

Author

Möddel, G., primary, Esser, B., additional, and Elger, C.E., additional

Published
2018
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6. Autoren

Author

Albers, P., primary, Andrié, R.P., additional, Angenendt, J., additional, Appenrodt, B., additional, Arkudas, A., additional, Aubin, H., additional, Autschbach, R., additional, Baldus, S., additional, Balzer, J., additional, Baltzer, J., additional, Behr, J., additional, Behrens, A., additional, Benz, Marcus, additional, Berger, M., additional, Berr, F., additional, Bischoff, S.C., additional, Böhm, A., additional, Böhm, M., additional, Bokemeyer, D., additional, Borowitzka, F., additional, Brüwer, M., additional, Buchfelder, M., additional, Burk, A., additional, Caca, K., additional, Daum, S., additional, Detter, C., additional, Diener, H.-C., additional, Domschke, W., additional, Doppler, K., additional, Elger, C.E., additional, Ell, C., additional, Ellinger, J., additional, Epple, H.-J., additional, Esser, B., additional, Ewen, Sebastian, additional, Fibbe, C., additional, Fichtner-Feigl, S., additional, Fiegel, P., additional, Fischbach, W., additional, Fischereder, M., additional, Fölsch, U.R., additional, Forsting, M., additional, Frey, N., additional, Freys, S.M., additional, Friedrich, M., additional, Frieling, T., additional, Frommberger, U., additional, Frühmorgen, P., additional, Geidel, S., additional, Germer, C.-T., additional, Goebel, F.-D., additional, Goetzenich, A., additional, Grabitz, K., additional, Greetfeld, M., additional, Groeneveld, A., additional, Groha, P.K., additional, Gundling, F., additional, Gutt, C.N., additional, Haak, T., additional, Hartmann, U., additional, Hauner, H., additional, Hausteiner-Wiehle, C., additional, Henningsen, P., additional, Herpertz-Dahlmann, B., additional, Heuß, D., additional, Heußner, P., additional, Hoffmann, J., additional, Hohenfellner, U., additional, Horch, R.E., additional, Hüll, M., additional, John, S., additional, Jordan, B., additional, Jurowich, C., additional, Käberich, A., additional, Katus, H., additional, Keck, C., additional, Kelm, M., additional, Kiehne, K., additional, Kilian, Adrienne, additional, Kindermann, I., additional, Kleindienst, A., additional, Klingel, K., additional, von Kodolitsch, Y., additional, Kölbl, H., additional, Koletzko, S., additional, Kollmar, O., additional, Konstantinidis, S., additional, Kramer, H.J., additional, Kreis, M.E., additional, Kroener-Herwig, B., additional, Kurschat, C., additional, Lammert, F., additional, Lamprecht, G., additional, Langosch, J.M., additional, Layer, P., additional, Leifeld, L., additional, Lichtenberg, A., additional, Lindner, K., additional, Link, A., additional, Lügering, N., additional, Lusch, Achim, additional, Marth, T., additional, Merle, U., additional, Mellert, F., additional, Meyer-Marcotty, M., additional, Michels, G., additional, Middeke, J.M., additional, Möddel, G., additional, Mössner, J., additional, Müller, A., additional, Müller, J.L., additional, Müller, R.-U., additional, Müller, S.C., additional, Müller-Lissner, S., additional, Müller-Werdan, U., additional, Neubrand, M., additional, Neuhof, C., additional, Parhofer, K.G., additional, Petri, E., additional, Pfeiffer, T., additional, Pilatz, Adrian, additional, Pizarro, C., additional, Pohle, T., additional, Polykandriotis, E., additional, Probst, C., additional, Rascher, W., additional, Rauch, B., additional, Reuss-Borst, M., additional, Riedner, C., additional, Rietschel, E., additional, Röckelein, V., additional, Rüster, Ch., additional, Ruß, M., additional, Sailer, M., additional, Sandmann, W., additional, Sauerbruch, T., additional, Schaaf, B., additional, Schaefer, C.A., additional, Schahab, N., additional, Schaper, A., additional, Schetelig, J., additional, Schmitz, M., additional, Schnürch, H.-G., additional, Schölmerich, J., additional, Schönermarck, Ulf, additional, Schrickel, J.W., additional, Schuchert, A., additional, Schunkert, H., additional, Segerer, S.E., additional, Senninger, N., additional, Seybold, U., additional, Siegmund, B., additional, Skowasch, D., additional, Sommer, C., additional, Spengler, U., additional, Stahl, M., additional, Stallmach, A., additional, Stolpmann, G., additional, Stremmel, W., additional, Sure, U., additional, Tacke, F., additional, te Wildt, B.T., additional, Trinkler, P., additional, Tröger, H., additional, Unnewehr, M., additional, Vloet, T., additional, Voderholzer, U., additional, Vogt, P.M., additional, von Scheidt, W., additional, Wagenlehner, F., additional, Wahlers, T., additional, Weber, L.T., additional, Wehrmann, T., additional, Weis-Müller, B.T., additional, Werdan, K., additional, Wintergerst, U., additional, Wittwer, T., additional, Wolf, Gunter, additional, Wölfling, K., additional, Wolkersdörfer, G., additional, Ziegler, D., additional, and Zierz, S., additional

Published
2018
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23. Collateral brain damage, a potential source of cognitive impairment after selective surgery for control of mesial temporal lobe epilepsy

Author

Helmstaedter, C., Vav Roost, D., Clusmann, H., Urbach, H., Elger, C.E., and Schramm, J.

Subjects
Nervous system -- Surgery, Epilepsy -- Research -- Care and treatment -- Complications and side effects, Health, Psychology and mental health, Care and treatment, Complications and side effects, Research
Abstract

J Neurol Neurosurg Psychiatry 2004;75:323-326 Background: Highly selective epilepsy surgery in temporal lobe epilepsy is intended to achieve seizure freedom at a lower cognitive risk than standard en bloc resections, [...]

Published
2004

26. Standard magnetic resonance imaging is inadequate for patients with refractory focal epilepsy. (Paper)

Author

Oertzen, J. Von, Urbach, H., Jungbluth, S., Kurthen, M., Reuber, M., Fernandez, G., and Elger, C.E.

Subjects
Magnetic resonance imaging -- Evaluation -- Usage, Epilepsy -- Care and treatment, Surgery -- Evaluation -- Usage, Health, Psychology and mental health, Care and treatment, Evaluation, Usage
Abstract

Objectives: Patients with intractable epilepsy may benefit from epilepsy surgery especially if they have a radiologically demonstrable cerebral lesion. Dedicated magnetic resonance imaging (MRI) protocols as performed at epilepsy surgery [...]

Published
2002

31. Rey Auditory-Verbal Learning Test: structure of a modified German version

Author

Muller, H., Hasse-Sander, I., Horn, R., Helmstaedter, C., and Elger, C.E.

Subjects
Psychiatric research -- Equipment and supplies, Verbal learning -- Testing, Memory -- Testing, Psychology and mental health
Abstract

The Auditory Verbal Learning Test (AVLT) is widely used in scientific research as well as in clinical practice. But there exists little research on the structure of the AVLT. We investigated the structure of a German version of the AVLT, and VLMT, in 232 patients of a psychiatric clinic and in 872 patients of an epileptologic clinic. First we stated a theoretical LISREL model relating the observed variables of the VLMT to short-term memory (STM) and long-term memory (LTM) as latent variables. Then we estimated the postulated LISREL model in the two samples. The proposed model showed excellent fit in both samples, and there were no significant deviations between the estimated and the observed covariance matrices. Thus, STM and LTM suffice to explain the structure of the VLMT, and the proposed structural equations model can be used to estimate STM and LTM capacity from VLMT data.

Published
1997

45. Exon-disrupting deletions ofNRXN1in idiopathic generalized epilepsy

Author

Møller, R.S., Weber, Y.G., Klitten, L.L., Trucks, H., Muhle, H., Kunz, W.S., Mefford, H.C., Franke, A., Kautza, M., Wolf, P., Dennig, D., Schreiber, S., Rückert, I.M., Wichmann, H.E., Ernst, J.P., Schurmann, C., Grabe, H.J., Tommerup, N., Stephani, U., Lerche, H., Hjalgrim, H., Helbig, I., Sander, T., Zimprich, F., Mörzinger, M., Feucht, M., Suls, A., Weckhuysen, S., Claes, L., Deprez, L., Smets, K., Van Dyck, T., Deconinck, T., De Jonghe, P., Velizarova, R., Dimova, P., Radionova, M., Tournev, I., Kancheva, D., Kaneva, R., Jordanova, A., Kjelgaard, D.B., Lehesjoki, A.E., Siren, A., Baulac, S., Leguern, E., Von Spiczak, S., Ostertag, P., Leber, M., Leu, C., Toliat, M.R., Nürnberg, P., Hempelmann, A., Rüschendorf, F., Elger, C.E., Kleefuß Lie, A.A., Surges, R., Gaus, V., Janz, D., Schmitz, B., Klein, K.M., Reif, P.S., Oertel, W.H., Hamer, H.M., Rosenow, F., Becker, F., Marini, C., Guerrini, R., Mei, D., Norci, V., Zara, F., Striano, P., Robbiano, A., Pezzella, M., Bianchi, A., Gambardella, A., Tinuper, P., La Neve, A., Capovilla, G., Vigliano, P., Crichiutti, G., Vanadia, F., Vignoli, A., Coppola, A., Striano, S., Giallonardo, M.T., Franceschetti, S., Belcastro, V., Benna, P., Coppola, G., De Palo, A., Ferlazzo, E., Vecchi, M., Martinelli, V., Bisulli, F., Beccaria, F., Del Giudice, E., Mancardi, M., Stranci, G., Scabar, A., Gobbi, G., Giordano, I., Koeleman, B.P.C., De Kovel, C., Lindhout, D., De Haan, G.J., Ozbeck, U., Bebek, N., Baykan, B., Ozdemir, O., Ugur, S., Kocasoy Orhan, E., Yücesan, E., Cine, N., Gokyigit, A., Gurses, C., Gul, G., Yapici, Z., Ozkara, C., Caglayan, H., Yalcin, O., Yalcin, D., Turkdogan, D., Dizdarer, G., Agan, K., R. S. Møller, Y. G. Weber, L. L. Klitten, H. Truck, H. Muhle, W. S. Kunz, H. C. Mefford, A. Franke, M. Kautza, P. Wolf, D. Dennig, S. Schreiber, I. Rückert, H. Wichmann, J. P. Ernst, C. Schurmann, H. J. Grabe, N. Tommerup, U. Stephani, H. Lerche, H. Hjalgrim, I. Helbig, T. Sander, P. Tinuper, F. Bisulli, EPICURE Consortium, Suls, Arvid, Weckhuysen, Sarah, Claes, Godelieve, Deprez, Liesbet, Smets, Katrien, Van Dyck, Tine, Deconinck, Tine, De Jonghe, Peter, Jordanova, Albena, Møller, R, Weber, Yg, Klitten, Ll, Trucks, H, Muhle, H, Kunz, W, Mefford, Hc, Franke, A, Kautza, M, Wolf, P, Dennig, D, Schreiber, S, Rückert, Im, Wichmann, He, Ernst, Jp, Schurmann, C, Grabe, Hj, Tommerup, N, Stephani, U, Lerche, H, Hjalgrim, H, Helbig, I, Sander, T, Epicure, Consortium, DEL GIUDICE, Ennio, Coppola, Antonietta, and YÜCESAN, EMRAH

Subjects
Male, Idiopathic generalized epilepsy, Neuronal, Idiopathic Generalized Epilepsy, 1q21, 1 Microdeletion, Two-hit Hypothesis, Nrxn1, Neuropsychological Tests, Immunoglobulin E, Cell Adhesion Molecules, Neuronal/genetics, Adult, Age of Onset, Anticonvulsant, Exon, 1q21.1 microdeletion, Exons/genetics, Odds Ratio, Nerve Tissue Proteins/genetics, Copy-number variation, Valproic Acid/therapeutic use, Age of Onset, Neural Cell Adhesion Molecules, genetics, DNA Copy Number Variations, Electroencephalography, Epilepsy, Genetics, biology, Triazines, Anticonvulsants/therapeutic use, Electroencephalography, genetics, Family, Female, Fructose, Exons, Middle Aged, Settore MED/39 - Neuropsichiatria Infantile, Pedigree, therapeutic use, Valproic Acid, Neurology, Settore MED/26 - Neurologia, Anticonvulsants, Epilepsy, Generalized, Female, Adult, Case-Control Studies, Cell Adhesion Molecules, Neuronal, DNA Copy Number Variations, Family, Fructose, Gene Deletion, Genotype, Humans, Infant, Microarray Analysis, Nerve Tissue Proteins, Valproic Acid, analogs /&/ derivatives/therapeutic use, Gene Deletion, Genotype, Humans, Infant, Male, Microarray Analysis, Middle Aged, Nerve Tissue Protein, therapeutic use, Case-Control Studies, Cell Adhesion Molecule, drug therapy/genetics/psychology, Exon, genetics, Neuropsychological Tests, Odds Ratio, Pedigree, Triazine, Lamotrigine, NRXN1, Topiramate, Epilepsy, Generalized/drug therapy, medicine, Allele, Biology, Gene, Generalized, Point mutation, Calcium-Binding Proteins, Odds ratio, medicine.disease, Triazines/therapeutic use, Settore MED/03 - Genetica Medica, therapeutic use, biology.protein, Fructose/analogs & derivatives, Human medicine, Neurology (clinical), Two-hit hypothesis
Abstract

Summary Purpose Neurexins are neuronal adhesion molecules located in the presynaptic terminal, where they interact with postsynaptic neuroligins to form a transsynaptic complex required for efficient neurotransmission in the brain. Recently, deletions and point mutations of the neurexin 1 (NRXN1) gene have been associated with a broad spectrum of neuropsychiatric disorders. This study aimed to investigate if NRXN1 deletions also increase the risk of idiopathic generalized epilepsies (IGEs). Methods We screened for deletions involving the NRXN1 gene in 1,569 patients with IGE and 6,201 controls using high-density oligonucleotide microarrays. Key Findings We identified exon-disrupting deletions of NRXN1 in 5 of 1,569 patients with IGE and 2 of 6,201 control individuals (p = 0.0049; odds ratio (OR) 9.91, 95% confidence interval (CI) 1.92–51.12). A complex familial segregation pattern in the IGE families was observed, suggesting that heterozygous NRXN1 deletions are susceptibility variants. Intriguingly, we identified a second large copy number variant in three of five index patients, supporting an involvement of heterogeneous susceptibility alleles in the etiology of IGE. Significance We conclude that exon-disrupting deletions of NRXN1 represent a genetic risk factor in the genetically complex predisposition of common IGE syndromes.

Published
2013
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46. Histopathological findings in brain tissue obtained during epilepsy surgery

Author

Blumcke, I., Spreafico, R., Haaker, G., Coras, Roland, Kobow, K., Bien, Christian G., Pfäfflin, M., Elger, C.E., Widman, G., Schramm, J., Becker, A., Braun, K. P., Leijten, F., Baayen, Johannes C, Aronica, E., Chassoux, F., Hamer, H.M., Stefan, H., Rössler, K., Thom, M., Walker, M. C., Sisodiya, Sanjay M., Duncan, J.S., McEvoy, A. W., Pieper, T., Holthausen, Hans, Kudernatsch, M., Meencke, H. J., Kahane, P., Schulze-Bonhage, A., Zentner, J., Heiland, D. H., Urbach, H., Steinhoff, Bernhard J, Bast, Thomas, Tassi, L., Russo, Maria Giovanna, Özkara, Cigdem, Oz, B., Krsek, Pavel, Vogelgesang, S., Runge, U., Lerche, H., Weber, Y.G., Honavar, M., Pimentel, J., Arzimanoglou, A., Ulate-Campos, A., Noachtar, S., Hartl, E., EEBB Consortium, Blumcke, I., Spreafico, R., Haaker, G., Coras, Roland, Kobow, K., Bien, Christian G., Pfäfflin, M., Elger, C.E., Widman, G., Schramm, J., Becker, A., Braun, K. P., Leijten, F., Baayen, Johannes C, Aronica, E., Chassoux, F., Hamer, H.M., Stefan, H., Rössler, K., Thom, M., Walker, M. C., Sisodiya, Sanjay M., Duncan, J.S., McEvoy, A. W., Pieper, T., Holthausen, Hans, Kudernatsch, M., Meencke, H. J., Kahane, P., Schulze-Bonhage, A., Zentner, J., Heiland, D. H., Urbach, H., Steinhoff, Bernhard J, Bast, Thomas, Tassi, L., Russo, Maria Giovanna, Özkara, Cigdem, Oz, B., Krsek, Pavel, Vogelgesang, S., Runge, U., Lerche, H., Weber, Y.G., Honavar, M., Pimentel, J., Arzimanoglou, A., Ulate-Campos, A., Noachtar, S., Hartl, E., and EEBB Consortium

Published
2017

47. Histopathological findings in brain tissue obtained during epilepsy surgery

Author

Zorglijn FNE Medisch, UMC Utrecht, ZL Kinder Ner en Nec Medisch, Brain, Pathologie, Blumcke, I., Spreafico, R., Haaker, G., Coras, Roland, Kobow, K., Bien, Christian G., Pfäfflin, M., Elger, C.E., Widman, G., Schramm, J., Becker, A., Braun, K. P., Leijten, F., Baayen, Johannes C, Aronica, E., Chassoux, F., Hamer, H.M., Stefan, H., Rössler, K., Thom, M., Walker, M. C., Sisodiya, Sanjay M., Duncan, J.S., McEvoy, A. W., Pieper, T., Holthausen, Hans, Kudernatsch, M., Meencke, H. J., Kahane, P., Schulze-Bonhage, A., Zentner, J., Heiland, D. H., Urbach, H., Steinhoff, Bernhard J, Bast, Thomas, Tassi, L., Russo, Maria Giovanna, Özkara, Cigdem, Oz, B., Krsek, Pavel, Vogelgesang, S., Runge, U., Lerche, H., Weber, Y.G., Honavar, M., Pimentel, J., Arzimanoglou, A., Ulate-Campos, A., Noachtar, S., Hartl, E., EEBB Consortium, Zorglijn FNE Medisch, UMC Utrecht, ZL Kinder Ner en Nec Medisch, Brain, Pathologie, Blumcke, I., Spreafico, R., Haaker, G., Coras, Roland, Kobow, K., Bien, Christian G., Pfäfflin, M., Elger, C.E., Widman, G., Schramm, J., Becker, A., Braun, K. P., Leijten, F., Baayen, Johannes C, Aronica, E., Chassoux, F., Hamer, H.M., Stefan, H., Rössler, K., Thom, M., Walker, M. C., Sisodiya, Sanjay M., Duncan, J.S., McEvoy, A. W., Pieper, T., Holthausen, Hans, Kudernatsch, M., Meencke, H. J., Kahane, P., Schulze-Bonhage, A., Zentner, J., Heiland, D. H., Urbach, H., Steinhoff, Bernhard J, Bast, Thomas, Tassi, L., Russo, Maria Giovanna, Özkara, Cigdem, Oz, B., Krsek, Pavel, Vogelgesang, S., Runge, U., Lerche, H., Weber, Y.G., Honavar, M., Pimentel, J., Arzimanoglou, A., Ulate-Campos, A., Noachtar, S., Hartl, E., and EEBB Consortium

Published
2017

48. Intracranial EEG correlates of implicit relational inference within the hippocampus

Author

Reber, T.P., Fell, J., Elger, C.E., Do Lam, A.T.A., Axmacher, N., Henke, Katharina, and Helmstaedter, C.

Subjects
150 Psychology, 610 Medicine & health
Abstract

Drawing inferences from past experiences enables adaptive behavior in future situations. Inference has been shown to depend on hippocampal processes. Usually, inference is considered a deliberate and effortful mental act which happens during retrieval, and requires the focus of our awareness. Recent fMRI studies hint at the possibility that some forms of hippocampus-dependent inference can also occur during encoding and possibly also outside of awareness. Here, we sought to further explore the feasibility of hippocampal implicit inference, and specifically address the temporal evolution of implicit inference using intracranial EEG. Presurgical epilepsy patients with hippocampal depth electrodes viewed a sequence of word pairs, and judged the semantic fit between two words in each pair. Some of the word pairs entailed a common word (e.g.,‘winter - red’, ‘red - cat’) such that an indirect relation was established in following word pairs (e.g, ‘winter - cat’). The behavioral results suggested that drawing inference implicitly from past experience is feasible because indirect relations seemed to foster ‘fit’ judgments while the absence of indirect relations fostered 'do not fit' judgments, even though the participants were unaware of the indirect relations. A event-related potential (ERP) difference emerging 400 ms post-stimulus was evident in the hippocampus during encoding, suggesting that indirect relations were already established automatically during encoding of the overlapping word pairs. Further ERP differences emerged later post-stimulus (1500 ms), were modulated by the participants' responses and were evident during encoding and test. Furthermore, response-locked ERP effects were evident at test. These ERP effects could hence be a correlate of the interaction of implicit memory with decision-making. Together, the data map out a time-course in which the hippocampus automatically integrates memories from discrete but related episodes to implicitly influence future decision making.

Published
2016
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