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4. Biological Effects of ERα-and ERβ-Selective Estrogens

Author

Fritzemeier, K.-H., Hillisch, A., Elger, W., Kaufmann, U., Kollenkirchen, U., Kosemund, D., Lindenthal, B., Müller, G., Muhn, P., Nubbemeyer, R., Peters, O., Siebel, P., Hegele-Hartung, C., Stock, G., editor, Lessl, M., editor, Korach, K. S., editor, Hillisch, A., editor, and Fritzemeier, K. H., editor

Published
2004
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12. Safety and efficacy of the selective progesterone receptor modulator asoprisnil for heavy menstrual bleeding with uterine fibroids: pooled analysis of two 12-month, placebo-controlled, randomized trials

Author

Stewart, E A, primary, Diamond, M P, additional, Williams, A R W, additional, Carr, B R, additional, Myers, E R, additional, Feldman, R A, additional, Elger, W, additional, Mattia-Goldberg, C, additional, Schwefel, B M, additional, and Chwalisz, K, additional

Published
2019
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13. Besonderheiten der Wirkungen der einzelnen Gestagene auf Morphologie und Funktion des Genitaltraktes

Author

Lauritzen, Ch., Lehmann, W.-D., Elger, W., Salloch, R. R., Hahn, J. D., Neumann, F., Steinbeck, H., Merker, H.-J., Eichler, O., editor, Farah, A., editor, Herken, H., editor, Welch, A. D., editor, Boschann, H.-W., editor, Buchholz, R., editor, Elger, W., editor, Hahn, J. D., editor, Jöchle, W., editor, Lauritzen, Christian, editor, Lehmann, W.-D., editor, Merker, H.-J., editor, Neumann, F., editor, Salloch, R. R., editor, and Steinbeck, H., editor

Published
1969
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23. Antiandrogene

Author

Neumann, F., Elger, W., Steinbeck, H., von Berswordt-Wallrabe, R., and Klein, Erich, editor

Published
1968
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27. Effects of estradiol and estradiol sulfamate on the uterus of ovariectomized or ovariectomized and hypophysectomized rats

Author

Lena Sahlin, Elger, W., Akerberg, S., Masironi, B., Reddersen, G., Schneider, B., Schwarz, S., Freyschuss, B., and Eriksson, H.

Subjects
Sulfonamides, Dose-Response Relationship, Drug, Estradiol, Injections, Subcutaneous, Ovariectomy, Endocrinology, Diabetes and Metabolism, Uterus, Clinical Biochemistry, Estrogen Receptor alpha, Radioimmunoassay, Administration, Oral, Organ Size, Cell Biology, Biochemistry, Rats, Endocrinology, Receptors, Estrogen, Animals, Molecular Medicine, Female, RNA, Messenger, Insulin-Like Growth Factor I, Rats, Wistar, Molecular Biology, Hypophysectomy
Abstract

Estradiol sulfamate (J995), estradiol-17beta with a substituted sulfamate group in position 3, has much higher systemic estrogenic activity after oral administration than 17beta-estradiol (E2) due to reduced hepatic metabolism of the drug. The lower dose necessary for achievement of adequate systemic estrogenic effects results in a substantial reduction of otherwise commonly observed hepatic side-effects. This makes J995 a strong candidate as an estrogen suitable for oral administration. The present study was performed to examine and compare the effects of J995 and E2 on the uterus after oral or subcutaneous administration to ovariectomized or ovariectomized+hypophysectomized female rats, in particular on the levels of the estrogen receptor (ER) (alpha+beta), ERalpha mRNA and insulin-like growth factor-I (IGF-I) mRNA. The ER levels were determined using a ligand binding assay and the mRNA levels using solution hybridization. The doses of J995 or E2 were chosen to achieve comparable uterotrophic activity. The rats were treated with hormones for 7 days and the treatment was initiated 14 days after surgery. We conclude that there are no major differences in the uterine response to treatment with J995 or E2 with respect to the effects on ER and ERalpha mRNA levels. The IGF-I mRNA level though, is more affected by J995 than by E2 after 7 days of treatment, indicating a prolonged effect of J995.

Published
2000
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29. Endokrinologie

Author

Wildt, L., Schwilden, H., Wesner, G., Roll, C., Luckhaus, J., Leyendecker, G., Maurer, W., Braendle, W., BEttendorf, G., Baumgarten, S., Römmler, A., Moltz, L., Schwartz, U., Hammerstein, J., Brückner, T., Nitschke-Dabelstein, S., Bollmann, W., Braun, S., Sturm, G., Wurster, K. G., Keller, E., Zwirner, M., Schindler, A. E., Jeschke, D., Berg, D., Michael, S., Mickan, H., Baumann, R., Dannhof, S., Taubert, H. -D., Schweditsch, M. O., Urdl, W., Pürstner, P., Braendle, W., Stegner, H. -E., Held, K., Bettendorf, G., Braendle, W., Zimmermann, R., Sprotte, C., Bettendorf, G., Kranzfelder, D., Mestwerdt, W., Korr, H., Zimmermann, R., Rodriguez-Rigau, L., Steinberger, E., Venn, H. J., Wildt, L., Braun, P., Schuhmacher, H., Hansmann, M., Leyendecker, G., Carstensen, M. H., Kleinkauf-Houcken, A., Simon, W., Nitschke-Dabelstein, S., Zwiens, G., Sturm, G., Geisthövel, F., Zabel, G., Skubsch, U., Schillinger, H., Breckwoldt, M., Moltz, L., Schwartz, U., Hammerstein, J., Grill, H. J., Manz, B., Elger, W., Pollow, K., Eiermann, W., Jawny, J., Hartmann, J., Luderschmidt, C., Hoffmann, G., Happ, J., Hey, O., Ackermann, R. H., Pollow, K., and Beyer, J.

Published
1983
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42. Erratum

Author

Boschann, H.-W., primary, Buchholz, R., additional, Elger, W., additional, Hahn, J. D., additional, Jöchle, W., additional, Lauritzen, Ch., additional, Lehmann, W.-D., additional, Merker, H.-J., additional, Neumann, F., additional, Salloch, R. R., additional, and Steinbeck, H., additional

Published
1969
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43. Participants

Author

Alberga, A., primary, Anders, H.-P., additional, Attramadal, A., additional, Baulieu, E.-E., additional, Baxter, J.D., additional, Beato, M., additional, Bernhard, S., additional, v. Berswordt-Wallrabe, R., additional, Best-Belpomme, M., additional, Bhargava, A.S., additional, Brescianai, F., additional, Breuer, H., additional, Brotherton, J., additional, Bush, I.E., additional, Clark, J.H., additional, Corvol, P., additional, Edelman, I.S., additional, El Etreby, M.F.A., additional, Elger, W., additional, Ellmer, H., additional, Erdos, T., additional, Gehring, U., additional, Gerhards, E., additional, Gibian, H., additional, Günzel, P., additional, Hasan, S., additional, Hechter, O., additional, de Hertogh, R., additional, Hocks, P., additional, Horowski, R., additional, Hughes, A., additional, Hughes-McCann, S., additional, Jones, T., additional, Jung, I., additional, Jungblut, P.W., additional, Karlson, P., additional, Kerb, U., additional, Kieslich, K., additional, King, R.J.B., additional, Kolb, K.-H., additional, Kopp, R., additional, Korenman, S.G., additional, Lachnit, U., additional, Lang, N., additional, Laudahn, G., additional, Laurent, H., additional, Lebeau, M.-C., additional, Liao, S., additional, Lindner, H.R., additional, Losert, W., additional, Maass, H., additional, Mainwaring, W.I.P., additional, Mannesmann, G., additional, Matthes, H., additional, Maurer, H.R., additional, Mehring, M., additional, Mester, J., additional, Milgrom, E., additional, van der Molen, H.J., additional, Mousseron-Canet, M., additional, Mühe, B., additional, Mueller, G.C., additional, Mützel, W., additional, Munck, A., additional, Neubert, D., additional, Neumann, F., additional, Nieuweboer, B., additional, Nishino, Y., additional, O'Malley, B.W., additional, Palenschat, D., additional, Paschelke, G., additional, Peters, S., additional, Piccinin, G.-L., additional, Puca, G.A., additional, Pujol-Amat, P., additional, Raspé, G., additional, Raynaud, J.P., additional, Raynaud-Jammet, C., additional, Richter, E., additional, Riemann, J., additional, Robel, P., additional, Robertson, D.M., additional, Rochefort, H., additional, Röpke, H., additional, Rosenfeld, G., additional, Salloch, R., additional, Schaumburg, B.P., additional, Schulz, K.-D., additional, Sekeris, C.E., additional, Seyfried, Ch., additional, Sharp, G.W.G., additional, Sherman, M.R., additional, Siewert, G., additional, Snart, R.S., additional, de Sombre, E.R., additional, Specht, K., additional, Spelsberg, T., additional, Steinbeck, H., additional, Sutherland, E.W., additional, Talwar, G.P., additional, Terenius, L., additional, Tomkins, G.M., additional, Truong, H., additional, Tveter, K.J., additional, Ufer, J., additional, Vita, G., additional, Voigt, K.D., additional, Vokaer, R., additional, Vorbüiggen, H., additional, Wacker, A., additional, Wagner, R.K., additional, Wendt, H., additional, Wenzel, M., additional, Wiechert, R., additional, Wiest, W.G., additional, Wira, Ch., additional, Wotiz, H.H., additional, and Wyss, H., additional

Published
1971
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