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Genus Angelica is one of the widely distributed and well-known genera of family Umbelliferae. It is utilized mainly by Chinese and Korean populations especially in their folk medicine. Angelica comprises a lot of medicinally important phytoconstituents such as coumarins, furanocoumarins, flavonoids, essential oils, verbascosides, polysaccharides, etc. Members of this genus play important roles, namely antioxidant, anti-inflammatory, anti-microbial, anti-diabetic, skin-whitening, cytotoxic, hepatoprotective, and many others. This review draws attention to many species of genus Angelica with much focus on A. dahurica being one of the highly medicinally used species within this genus. [ABSTRACT FROM AUTHOR]

The 70 % methanolic extracts of three Rosa varieties (aerial parts & flowers); Rosa banksiae var. banksiae Ait. (RBW); Rosa polyantha Thunb. 'orange fairy' (RPO) and Rosa polyantha Thunb. 'white fairy' (RPW) were quantified using UPLC-ESI-MS/MS. Sixty one compounds were identified where flavonoid glycosides were the most abundant. Principal component analysis (PCA) and Hierarchical cluster analysis (HCA) discriminated the six samples into four clusters where RBW-F & RPW-A formed one cluster, RPW-F & RPO-F formed another and RPO-A and RBW-A were in two separate clusters. The six Rosa extracts were tested as insecticidal agents against Culex pipiens L. larvae and pupae and their fecundity reducing activity was evaluated for the emerging adult mosquitoes. RPW flowers and aerial parts’ extracts demonstrated powerful larvicidal and pupicidal activities with LC50 373.3 and 383.2 ppm, respectively. Sterility indices reached 51.4% at highest concentrations used. All flower extracts possessed significantly high mortality and sterility activities (P < 0.001) compared to the aerial parts (P < 0.01).The UPLC-MS/MS metabolic profile of the extracts showed their richness in polyphenolic compounds. The 70% methanolic extracts of RBW, RPO and RPW aerial parts and flowers can be utilized as natural and safe plantbased insecticides for C. pipiens (filariasis vector) control. [ABSTRACT FROM AUTHOR]

Myocardial infarction (MI) is considered one of the most common cardiac diseases and major cause of death worldwide. The prevalence of MI and MI-associated mortality have been increasing in recent years due to poor lifestyle habits viz. residency, obesity, stress, and pollution. Synthetic drugs for the treatment of MI provide good chance of survival; however, the demand to search more safe, effective, and natural drugs is increasing. Plants provide fruitful sources for powerful antioxidant and anti-inflammatory agents for prevention and/or treatment of MI. However, many plant extracts lack exact information about their possible dosage, toxicity and drug interactions which may hinder their usefulness as potential treatment options. Phytoconstituents play cardioprotective role by either acting as a prophylactic or adjuvant therapy to the concurrently used synthetic drugs to decrease the dosage or relief the side effects of such drugs. This review highlights the role of different herbal formulations, examples of plant extracts and types of several isolated phytoconstituents (phenolic acids, flavonoids, stilbenes, alkaloids, phenyl propanoids) in the prevention of MI with reported activities. Moreover, their possible mechanisms of action are also discussed to guide future research for the development of safer substitutes to manage MI., (© 2024 John Wiley & Sons Ltd.)