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Your search keyword '"Elhindawy, Eman M."' showing total 6 results
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6 results on '"Elhindawy, Eman M."'

1. Association of ACE1 I/D polymorphism and susceptibility to COVID-19 in Egyptian children and adolescents

Author

Boraey, Naglaa F., Bebars, Marwa A., Wahba, Ali A., Abd El Lateef, Hanan M., Attia, Mohamed Atif, Elsayed, Ahmed H., Rashed, Khalid A., Sorour, Ehab I., Ahmed, Mohamed F., Abd-Elrehim, Ghada A. B., Soliman, Attia A., Shehab, Mohamed M. M., Elhindawy, Eman M., Ibraheem, Ahmed A. A., Shehata, Hassan, Yousif, Yousif M., Hashem, Mustafa I. A., Ahmed, Amani A., Emam, Ahmed A., Gameil, Dalia M., Abdelhady, Eman M., Abdelkhalek, Khalil, Morsi, Walaa E. M. A., Selim, Dalia M., Razek, Suzan A., Ashraf, Bassem, Saleh, Ahmed S. E., Eltrawy, Heba H., Alanwar, Mohamed I., Fouad, Rania A., Omar, Walaa E., Nabil, Rehab M., Abdelhamed, Mohamed R., Ibrahim, Mona Yousri, Malek, Mai M., Afify, Mona R., Alharbi, Mohanned T., Nagshabandi, Mohammed K., Tarabulsi, Muyassar K., Qashqary, Mohammed Esmail, Almoraie, Laila M., Salem, Hanan F., Rashad, Manal M., El-Gaaly, Sonya A. A., El- Deeb, Nahawand A., Abdallah, Amany M., Fakhreldin, Ahmed R., Hassouba, Mohamed, Massoud, Yasmine M., Attaya, Mona S. M., and Haridi, Mohammed K.

Published
2024
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2. Association of ACE1I/D polymorphism and susceptibility to COVID-19 in Egyptian children and adolescents

Author

Boraey, Naglaa F., Bebars, Marwa A., Wahba, Ali A., Abd El Lateef, Hanan M., Attia, Mohamed Atif, Elsayed, Ahmed H., Rashed, Khalid A., Sorour, Ehab I., Ahmed, Mohamed F., Abd-Elrehim, Ghada A. B., Soliman, Attia A., Shehab, Mohamed M. M., Elhindawy, Eman M., Ibraheem, Ahmed A. A., Shehata, Hassan, Yousif, Yousif M., Hashem, Mustafa I. A., Ahmed, Amani A., Emam, Ahmed A., Gameil, Dalia M., Abdelhady, Eman M., Abdelkhalek, Khalil, Morsi, Walaa E. M. A., Selim, Dalia M., Razek, Suzan A., Ashraf, Bassem, Saleh, Ahmed S. E., Eltrawy, Heba H., Alanwar, Mohamed I., Fouad, Rania A., Omar, Walaa E., Nabil, Rehab M., Abdelhamed, Mohamed R., Ibrahim, Mona Yousri, Malek, Mai M., Afify, Mona R., Alharbi, Mohanned T., Nagshabandi, Mohammed K., Tarabulsi, Muyassar K., Qashqary, Mohammed Esmail, Almoraie, Laila M., Salem, Hanan F., Rashad, Manal M., El-Gaaly, Sonya A. A., El- Deeb, Nahawand A., Abdallah, Amany M., Fakhreldin, Ahmed R., Hassouba, Mohamed, Massoud, Yasmine M., Attaya, Mona S. M., and Haridi, Mohammed K.

Abstract

Background: Given the sparse data on the renin-angiotensin system (RAS) and its biological effector molecules ACE1 and ACE2 in pediatric COVID-19 cases, we investigated whether the ACE1insertion/deletion (I/D) polymorphism could be a genetic marker for susceptibility to COVID-19 in Egyptian children and adolescents. Methods: This was a case-control study included four hundred sixty patients diagnosed with COVID-19, and 460 well-matched healthy control children and adolescents. The I/D polymorphism (rs1799752) in the ACE1gene was genotyped by polymerase chain reaction (PCR), meanwhile the ACE serum concentrations were assessed by ELISA. Results: The ACE1D/D genotype and Deletion allele were significantly more represented in patients with COVID-19 compared to the control group (55% vs. 28%; OR = 2.4; [95% CI: 1.46–3.95]; for the DD genotype; P= 0.002) and (68% vs. 52.5%; OR: 1.93; [95% CI: 1.49–2.5] for the D allele; P= 0.032). The presence of ACE1D/D genotype was an independent risk factor for severe COVID-19 among studied patients (adjusted OR: 2.6; [95% CI: 1.6–9.7]; P< 0.001. Conclusions: The ACE1insertion/deletion polymorphism may confer susceptibility to SARS-CoV-2 infection in Egyptian children and adolescents. Impact:

Recent studies suggested a crucial role of renin-angiotensin system and its biological effector molecules ACE1 and ACE2 in the pathogenesis and progression of COVID-19.

To our knowledge, ours is the first study to investigate the association of ACE1 I/D polymorphism and susceptibility to COVID-19 in Caucasian children and adolescents.

The presence of the ACE1 D/D genotype or ACE1 Deletion allele may confer susceptibility to SARS-CoV-2 infection and being associated with higher ACE serum levels; may constitute independent risk factors for severe COVID-19.

The ACE1 I/D genotyping help design further clinical trials reconsidering RAS-pathway antagonists to achieve more efficient targeted therapies.

Published
2024
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3. Interleukin-10 -1082 G/A gene polymorphisms in Egyptian children with CAP: A case–control study

Author

Azab, Seham F., Abdalhady, Mohamed A., Elsaadany, Hosam F., Elkomi, Mohamed A., Elhindawy, Eman M., Sarhan, Dina T., Salam, Mohamed M.A., Allah, Mayy A.N., Emam, Ahmed A., Noah, Maha A., Abdelsalam, Nasser I., Abdellatif, Sawsan H., Rass, Anwar A., Ismail, Sanaa M., Gheith, Tarek, Aziz, Khalid A., Hamed, Mohammed E., Abdelrahman, Hind M., Ahmed, Ahmed R., Nabil, Rehab M., Abdulmaksoud, Rehab S., and Yousef, Hala Y.

Published
2016
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4. Serum Hepcidin Levels in Childhood-Onset Ischemic Stroke

Author

Azab, Seham F., Akeel, Nagwa E., Abdalhady, Mohamed A., Elhewala, Ahmed A., Ali, Al Shymaa A., Amin, Ezzat K., Sarhan, Dina T., Almalky, Mohamed A.A., Elhindawy, Eman M., Salam, Mohamed M.A., Soliman, Attia A., Abdellatif, Sawsan H., Ismail, Sanaa M., Elsamad, Nahla A., Hashem, Mustafa I.A., Aziz, Khalid A., Elazouni, Osama M.A., and Arafat, Manal S.

Subjects
Male, Adolescent, Interleukin-6, Injections, Subcutaneous, Observational Study, Infant, Enzyme-Linked Immunosorbent Assay, Brain Ischemia, Stroke, Hepcidins, Child, Preschool, Acute Disease, Ferritins, Receptors, Transferrin, Humans, Female, Enoxaparin, Child, Research Article
Abstract

Recently, hepcidin, an antimicrobial-like peptide hormone, has evolved as the master regulator of iron homeostasis. Despite the growing evidence of iron imbalance in childhood-onset ischemic stroke, serum hepcidin level in those patients has not yet been researched. In this study, we aimed to estimate serum (hepcidin) level in acute ischemic stroke (AIS) patients and to investigate whether subcutaneous enoxaparin sodium, which is a low-molecular-weight heparin (LMWH) derivative, could modulate serum hepcidin level in those patients. This was a case–control study included 60 (AIS) cases, and 100 healthy children with comparable age and gender as control group. For all subjects’ serum hepcidin, interleukin-6 (IL-6), and soluble transferrin receptor [sTfR]) levels were assessed by (enzyme-linked immunosorbent assay [ELISA] method). Iron parameters including (serum iron, ferritin, transferrin, and total iron binding capacity [TIBC]) were also measured. The patients were subdivided according to treatment with an LMWH derivative into 2 groups and serum hepcidin levels were assessed initially and 1 week after stroke onset for all cases. We found that AIS cases had higher serum iron, ferritin, and IL6 levels compared to the control group (all P 0.05). However, on the 7th day of diagnosis serum hepcidin level decreased significantly in AIS cases treated with LMWH (group 1) (median, 36 vs 21 ng/mL; P 0.05). Serum hepcidin showed significant positive correlations with serum iron, transferrin saturation, ferritin, and IL6 (r = 0.375, P

Published
2016

5. Serum and CSF adiponectin, leptin, and interleukin 6 levels as adipocytokines in Egyptian children with febrile seizures: a cross-sectional study

Author

Azab, Seham F., primary, Abdalhady, Mohamed A., additional, Almalky, Mohamed A. A., additional, Amin, Ezzat K., additional, Sarhan, Dina T., additional, Elhindawy, Eman M., additional, Allah, Mayy A. N., additional, Elhewala, Ahmed A., additional, Salam, Mohamed M. A., additional, Hashem, Mustafa I. A., additional, Soliman, Attia A., additional, Akeel, Nagwa E., additional, Abdellatif, Sawsan H., additional, Elsamad, Nahla A., additional, Rass, Anwar A., additional, and Arafat, Manal S., additional

Published
2016
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6. Interleukin-6 gene polymorphisms in Egyptian children with febrile seizures: a case–control study

Author

Azab, Seham F., primary, Abdalhady, Mohamed A., additional, Ali, Alshaymaa, additional, Amin, Ezzat K., additional, Sarhan, Dina T., additional, Elhindawy, Eman M., additional, Almalky, Mohamed A. A., additional, Elhewala, Ahmed A., additional, Salam, Mohamed M. A., additional, Hashem, Mustafa I. A., additional, Soliman, Attia A., additional, Akeel, Nagwa E., additional, Abdellatif, Sawsan H., additional, Ismail, Sanaa M., additional, Elsamad, Nahla A., additional, Arafat, Manal S., additional, Rass, Anwar A., additional, and Basset, Maha A. A., additional

Published
2016
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