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5 results on '"Elisabeth Collins"'

3. Evaluating Transcranial Focused Ultrasound Stimulation (tFUS) for Targeted Neuromodulation in Generalized Anxiety Disorder: A Double-Blind Feasibility Study

Author

Norman M. Spivak, Andrew J. Swenson, Jonathan Haroon, Bridgette Holland, Morgan Dancy, Elisabeth Collins, Ashley Hayden, Jason Marum, Martin M. Monti, Samantha F. Schafer, Mark E. Schafer, Tina Chou, Darin D. Dougherty, Mark S. George, Alexander Bystritsky, Susan Bookheimer, Taylor Kuhn, and Margaret Distler

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Published
2025
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4. Phase 2 Multicenter Study of Pomalidomide (POM) Plus Low-Dose Dexamethasone (LoDEX) in Patients (Pts) With Relapsed/Refractory Multiple Myeloma (RRMM) and Renal Impairment (RI): An Updated Safety Analysis

Author

Weisel, Katja Dimopoulos, Meletios Athanasios Van de Donk, Niels and Ramasamy, Karthik Gamberi, Barbara Streetly, Matthew and Offidani, Massimo Bridoux, Frank de la Rubia, Javier and Kueenburg, Elisabeth Collins, Shona Lersch, Frederik and Rosettani, Barbara Bacon, Pamela Sonneveld, Pieter and Weisel, Katja Dimopoulos, Meletios Athanasios Van de Donk, Niels and Ramasamy, Karthik Gamberi, Barbara Streetly, Matthew and Offidani, Massimo Bridoux, Frank de la Rubia, Javier and Kueenburg, Elisabeth Collins, Shona Lersch, Frederik and Rosettani, Barbara Bacon, Pamela Sonneveld, Pieter

Published
2017

5. Identification of Potent and Selective MMP-13 Inhibitors

Author

Mary Geck, Zhang-Bao Xu, Rajeev Hotchandani, Jeremy I. Levin, Junjun Wu, Xuemei Du, Thomas S. Rush, J.S. Skotnicki, Elisabeth Collins, and Frank Lovering

Subjects
Models, Molecular, Matrix metalloproteinase inhibitor, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Articular cartilage, Pharmacology, Matrix metalloproteinase, Crystallography, X-Ray, Biochemistry, Substrate Specificity, Drug Discovery, Amino Acids, Chelating Agents, media_common, chemistry.chemical_classification, biology, Chemistry, General Medicine, Zinc, Enzyme inhibitor, Molecular Medicine, Selectivity, Drug, media_common.quotation_subject, In Vitro Techniques, Matrix Metalloproteinase Inhibitors, Sensitivity and Specificity, Inhibitory Concentration 50, Structure-Activity Relationship, Pharmacokinetics, Matrix Metalloproteinase 13, Animals, Structure–activity relationship, Protease Inhibitors, Chelation, Collagenases, Molecular Biology, Benzofurans, Organic Chemistry, In vitro, Protein Structure, Tertiary, Rats, Bioavailability, Cartilage, Enzyme, Drug Design, biology.protein, Cattle, Explant culture
Abstract

A potent, selective series of MMP-13 inhibitors has been derived from a weak (3.2 microM) inhibitor that did not bear a zinc chelator. Structure-based drug design strategies were employed to append a Zn-chelating group to one end of the molecule and functionality to enhance selectivity to the other. A compound from this series demonstrated rat oral bioavailability and efficacy in a bovine articular cartilage explant model.

Published
2005
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