1. Quality of life is modestly improved in older patients with mild primary hyperparathyroidism postoperatively: results of a prospective multicenter study
- Author
-
Jean-Benoit Hardouin, Catherine Ansquer, Damien Masson, Antoine Hamy, Jean-François Henry, Delphine Drui, Claire Blanchard, Elise van Nuvel, Muriel Mathonnet, Frederic Sebag, Caroline Kubis, C. Caillard, Françoise Kraeber-Bodéré, Eric Mirallié, Rasa Zarnegar, unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Chirurgie digestive, endocrinienne et générale [CHU Limoges], CHU Limoges, Service de chirurgie générale et endocrinienne, Hôpital de la Timone [CHU - APHM] (TIMONE), Clinique de chirurgie digestive et endocrinienne, IMAD, Département d'endocrinologie, Centre hospitalier universitaire de Nantes (CHU Nantes), Département de Biochimie [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes)-Hôpital Nord Laennec [CHU Nantes], Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), Service de Médecine Nucléaire [Nantes], Hôpital Laennec, Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, Biostatistique, Pharmacoépidémiologie et Mesures Subjectives en Santé, PRES Université Nantes Angers Le Mans (UNAM), Division of Endocrine and Minimally Invasive Surgery, Departments of Surgery and Public Health, Weill Medical College of Cornell University [New York]-Weill Medical College of Cornell University [New York], Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Laboratoire d'Informatique Gaspard-Monge (LIGM), and Université Paris-Est Marne-la-Vallée (UPEM)-École des Ponts ParisTech (ENPC)-ESIEE Paris-Fédération de Recherche Bézout-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Parathyroidectomy ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,Subgroup analysis ,Quality of life ,Surgical oncology ,Surveys and Questionnaires ,medicine ,Humans ,Postoperative Period ,Prospective Studies ,Prospective cohort study ,Aged ,Neoplasm Staging ,Aged, 80 and over ,Hyperparathyroidism ,business.industry ,Middle Aged ,medicine.disease ,Hyperparathyroidism, Primary ,Prognosis ,humanities ,Surgery ,Oncology ,Multicenter study ,Quality of Life ,Female ,business ,Primary hyperparathyroidism ,Follow-Up Studies - Abstract
International audience; BACKGROUND: The objectives of this study were to evaluate, in mild primary hyperparathyroidism (pHPT) patients, the quality of life (QoL) using the SF-36 questionnaire before and after parathyroidectomy and to detect preoperatively patients who benefit the most from surgery. Most pHPT patients present a mild pHPT defined by calcemia ≤11.4mg/dL. For these patients, there is debate about whether they should be managed with surveillance, medical therapy, or surgery.METHODS: A prospective multicenter study investigated QoL (SF-36) in patients with mild pHPT before and after parathyroidectomy in four university hospitals. Laboratory results and SF-36 scores were obtained preoperatively and postoperatively (3, 6, and 12months).RESULTS: One hundred sixteen patients were included. After surgery, the biochemical cure rate was 98%. Preoperatively, the mental component summary and the physical component summary (PCS) were 38.69 of 100 and 39.53 of 100, respectively. At 1year, the MCS and the PCS were 41.29 of 100 and 42.03 of 100. The subgroup analysis showed a more significant improvement in patientsCONCLUSIONS: This study showed, in patients with mild pHPT, an improvement of QoL 1year after parathyroidectomy. Patients
- Published
- 2013