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2. Prevalence of transthyretin amyloid cardiomyopathy in patients admitted for acute heart failure.

Author

Spaccavento, Ana, Rodríguez, María del Rosario, Meretta, Alejandro, Elissamburu, Pablo, Carvelli, Victoria, Gobbo, Magalí, Rosa, Daniel, Masoli, Osvaldo, Conde, Diego, and Costabel, Juan Pablo

Abstract

Transthyretin amyloid cardiomyopathy (ATTR-CM) is an underdiagnosed cause of AHF that benefits from a specific approach. The aim was to determine the prevalence of ATTR-CM among patients hospitalized for AHF. A prospective study was conducted on consecutive patients aged 60 or older admitted for acute AHF without cardiogenic shock. The study included 103 patients, a total of 16 patients (15.5 %) were compatible with ATTR-CM. The ATTR-CM group showed a higher septal wall thickness (18.1 mm vs. 11.8 mm; P = 0.001), lower systolic excursion of the tricuspid annular plane (15 mm vs. 18.3 mm, P = 0.014), and S wave of the right ventricle (8 cm/s vs. 9.2 cm/s P=0.032). ATTR-CM is an underdiagnosed condition, there are some variables associated with its diagnosis. The coexistence with other comorbidities causing AHF, highlights the importance of considering screening for this cardiomyopathy in adults hospitalized for AHF. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Poster Session 2: Thursday 8 December 2011, 14:00-18:00 * Location: Poster Area

Author

Luo, X., primary, Fang, F., additional, Sun, J., additional, Xie, J., additional, Lee, A., additional, Zhang, Q., additional, Yu, C., additional, Breithardt, O., additional, Schiessl, S., additional, Schmid, M., additional, Seltmann, M., additional, Klinghammer, L., additional, Zeissler, C., additional, Kuechle, M., additional, Daniel, W., additional, Ege, M., additional, Guray, U., additional, Guray, Y., additional, Demirkan, B., additional, Kisacik, H., additional, Kim, S.-E., additional, Hong, J.-Y., additional, Lee, J.-H., additional, Park, D.-G., additional, Han, K.-R., additional, Oh, D.-J., additional, Tufekcioglu, O., additional, Cozma, D. C., additional, Mornos, C., additional, Ionac, A., additional, Petrescu, L., additional, Tutuianu, C., additional, Dragulescu, S. I., additional, Guimaraes, L., additional, Tavares, G., additional, Rodrigues, A., additional, Nagamatsu, C., additional, Fischer, C., additional, Vieira, M., additional, Oliveira, W., additional, Wilberg, T., additional, Cordovil, A., additional, Morhy, S., additional, Muraru, D., additional, Peluso, M., additional, Dal Bianco, L., additional, Beraldo, M., additional, Solda', E., additional, Tuveri, M., additional, Cucchini, U., additional, Al Mamary, A., additional, Badano, L., additional, Iliceto, S., additional, Pizzuti, A., additional, Mabritto, B., additional, Derosa, C., additional, Tomasello, A., additional, Rovere, M., additional, Parrini, I., additional, Conte, M., additional, Lareva, N., additional, Govorin, A., additional, Cooper, R., additional, Sharif, J., additional, Somauroo, J. D., additional, Hung, J. D., additional, Porcelli, V., additional, Skevington, R., additional, Shahzad, A., additional, Scott, S., additional, Lindqvist, P., additional, Soderberg, S., additional, Gonzalez, M., additional, Tossavainen, E., additional, Henein, M., additional, Nciri, N., additional, Saad, H., additional, Nawas, S., additional, Ali, A., additional, Youssufzay, A., additional, Safi, A., additional, Faruk, S., additional, Yurdakul, S., additional, Erdemir, V., additional, Tayyareci, Y., additional, Yildirimturk, O., additional, Memic, K., additional, Aytekin, V., additional, Gurel, M., additional, Aytekin, S., additional, Przewlocka-Kosmala, M., additional, Cielecka-Prynda, M., additional, Mysiak, A., additional, Kosmala, W., additional, Pescariu, S., additional, Cozma, D., additional, Mornos, A., additional, Dragulescu, S., additional, Maurea, N., additional, Tocchetti, C. G., additional, Coppola, C., additional, Quintavalle, C., additional, Rea, D., additional, Barbieri, A., additional, Piscopo, G., additional, Arra, C., additional, Condorelli, G., additional, Iaffaioli, R., additional, Dalen, H., additional, Thorstensen, A., additional, Moelmen, H., additional, Torp, H., additional, Stoylen, A., additional, Augustine, D., additional, Basagiannis, C., additional, Suttie, J., additional, Cox, P., additional, Aitzaz, R., additional, Lewandowski, A., additional, Lazdam, M., additional, Holloway, C., additional, Becher, H., additional, Leeson, P., additional, Radovanovic, S., additional, Djokovic, A., additional, Todic, B., additional, Zdravkovic, M., additional, Zaja-Simic, M., additional, Banicevic, S., additional, Lisulov-Popovic, D., additional, Krotin, M., additional, Grapsa, J., additional, O'regan, D., additional, Dawson, D., additional, Durighel, G., additional, Howard, L., additional, Gibbs, J., additional, Nihoyannopoulos, P., additional, Tulunay Kaya, C., additional, Kilickap, M., additional, Kurklu, H., additional, Ozbek, N., additional, Koca, C., additional, Kozluca, V., additional, Esenboga, K., additional, Erol, C., additional, Kusmierczyk-Droszcz, B., additional, Kowalik, E., additional, Niewiadomska, J., additional, Hoffman, P., additional, Satendra, M., additional, Sargento, L., additional, Lopes, S., additional, Longo, S., additional, Lousada, N., additional, Palma Reis, R., additional, Chillo, P., additional, Rieck, A., additional, Lwakatare, J., additional, Lutale, J., additional, Gerdts, E., additional, Bonapace, S., additional, Molon, G., additional, Targher, G., additional, Rossi, A., additional, Lanzoni, L., additional, Canali, G., additional, Campopiano, E., additional, Zenari, L., additional, Bertolini, L., additional, Barbieri, E., additional, Hristova, K., additional, Vladiomirova-Kitova, L., additional, Katova, T., additional, Nikolov, F., additional, Nikolov, P., additional, Georgieva, S., additional, Simova, I., additional, Kostova, V., additional, Kuznetsov, V. A., additional, Krinochkin, D. V., additional, Chandraratna, P. A., additional, Pak, Y. A., additional, Zakharova, E. H., additional, Plusnin, A. V., additional, Semukhin, M. V., additional, Gorbatenko, E. A., additional, Yaroslavskaya, E. I., additional, Bedetti, G., additional, Gargani, L., additional, Scalese, M., additional, Pizzi, C., additional, Sicari, R., additional, Picano, E., additional, Reali, M., additional, Canali, E., additional, Cimino, S., additional, Francone, M., additional, Mancone, M., additional, Scardala, R., additional, Boccalini, F., additional, Hiramoto, Y., additional, Frustaci, A., additional, Agati, L., additional, Savino, K., additional, Lilli, A., additional, Bordoni, E., additional, Riccini, C., additional, Ambrosio, G., additional, Silva, D., additional, Cortez-Dias, N., additional, Carrilho-Ferreira, P., additional, Jorge, C., additional, Silva-Marques, J., additional, Magalhaes, A., additional, Santos, L., additional, Ribeiro, S., additional, Pinto, F., additional, Nunes Diogo, A., additional, Kinova, E., additional, Zlatareva, N., additional, Goudev, A., additional, Bonanad, C., additional, Lopez-Lereu, M., additional, Monmeneu, J., additional, Bodi, V., additional, Sanchis, J., additional, Nunez, J., additional, Chaustre, F., additional, Llacer, A., additional, Ermacora, D., additional, Peluso, D., additional, Di Lazzari, M., additional, Meimoun, P., additional, Elmkies, F., additional, Benali, T., additional, Boulanger, J., additional, Zemir, H., additional, Clerc, J., additional, Luycx-Bore, A., additional, Velasco Del Castillo, M. S., additional, Cacicedo Fernandez De Bobadilla, A., additional, Onaindia Gandarias, J., additional, Telleria Arrieta, M., additional, Zugazabeitia Irazabal, G., additional, Quintana Raczka, O., additional, Rodriguez Sanchez, I., additional, Romero Pereiro, A., additional, Laraudogoitia Zaldumbide, E., additional, Lekuona Goya, I., additional, Bonello, B., additional, El Louali, E., additional, Fouilloux, V., additional, Kammache, I., additional, Ovaert, C., additional, Kreitmann, B., additional, Fraisse, A., additional, Migliore, R., additional, Adaniya, M., additional, Barranco, M., additional, Miramont, G., additional, Tamagusuku, H., additional, Alassar, A., additional, Sharma, R., additional, Marciniak, A., additional, Valencia, O., additional, Abdulkareem, N., additional, Jahangiri, M., additional, Jander, N., additional, Kienzle, R., additional, Gohlke-Baerwolf, C., additional, Gohlke, H., additional, Neumann, F.-J., additional, Minners, J., additional, Valbuena, S., additional, De Torres, F., additional, Lopez, T., additional, Gomez, J. J., additional, Guzman, G., additional, Dominguez, F., additional, Refoyo, E., additional, Moreno, M., additional, Lopez-Sendon, J. L., additional, Ancona, R., additional, Comenale Pinto, S., additional, Caso, P., additional, Di Salvo, G., additional, Severino, S., additional, Cavallaro, M., additional, Calabro, R., additional, Enache, R., additional, Piazza, R., additional, Roman-Pognuz, A., additional, Popescu, B., additional, Calin, A., additional, Beladan, C., additional, Purcarea, F., additional, Nicolosi, G., additional, Ginghina, C., additional, Savu, O., additional, Rosca, M., additional, Jurcut, R., additional, Serban, M., additional, Dorobantu, L., additional, Donal, E., additional, Mascle, S., additional, Thebault, C., additional, Veillard, D., additional, Hamonic, H., additional, Leguerrier, A., additional, Corbineau, H., additional, Popa, B. A., additional, Diena, M., additional, Bogdan, A., additional, Benea, D., additional, Lanzillo, G., additional, Casati, V., additional, Novelli, E., additional, Popa, A., additional, Cerin, G., additional, Gual Capllonch, F., additional, Teis, A., additional, Lopez Ayerbe, J., additional, Ferrer, E., additional, Vallejo, N., additional, Gomez Denia, E., additional, Bayes Genis, A., additional, Spethmann, S., additional, Schattke, S., additional, Baldenhofer, G., additional, Stangl, V., additional, Laule, M., additional, Baumann, G., additional, Stangl, K., additional, Knebel, F., additional, Labata, C., additional, Garcia Alonso, C., additional, Gual, F., additional, Nunez Aragon, R., additional, Sousa, C., additional, Vasile, A. I., additional, Dorobantu, M., additional, Iorgulescu, C., additional, Bogdan, S., additional, Constantinescu, D., additional, Caldararu, C., additional, Tautu, O., additional, Vatasescu, R., additional, Badran, H., additional, Elnoamany, M. F., additional, Ayad, M., additional, Elshereef, A., additional, Farhan, A., additional, Nassar, Y., additional, Yacoub, M., additional, Costabel, J., additional, Avegliano, G., additional, Elissamburu, P., additional, Thierer, J., additional, Castro, F., additional, Huguet, M., additional, Frangi, A., additional, Ronderos, R., additional, Prinz, C., additional, Van Buuren, F., additional, Faber, L., additional, Bitter, T., additional, Bogunovic, N., additional, Burchert, W., additional, Horstkotte, D., additional, Kasprzak, J. D., additional, Smialowski, A., additional, Rudzinski, T., additional, Lipiec, P., additional, Krzeminska-Pakula, M., additional, Wierzbowska-Drabik, K., additional, Trzos, E., additional, Kurpesa, M., additional, Motoki, H., additional, Hana, M., additional, Marwick, T., additional, Allan, K., additional, Vazquez-Alvarez, M., additional, Medrano Lopez, C., additional, Granja Da Silva, S., additional, Marcos, C., additional, Rodriguez-Ogando, A., additional, Alvarez, M., additional, Camino, M., additional, Centeno, M., additional, Maroto, E., additional, Feltes Guzman, G., additional, Serra Tomas, V., additional, Acevedo, O., additional, Calli, A., additional, Barba, M., additional, Pintos, G., additional, Valverde, V., additional, Zamorano Gomez, J., additional, Marchel, M., additional, Kochanowski, J., additional, Piatkowski, R., additional, Madej, A., additional, Filipiak, K., additional, Hausmanowa-Petrusewicz, I., additional, Opolski, G., additional, Malev, E., additional, Zemtsovsky, E., additional, Reeva, S., additional, Timofeev, E., additional, Pshepiy, A., additional, Mihaila, S., additional, Rimbas, R., additional, Mincu, R., additional, Dulgheru, R., additional, Mihaila, R., additional, Badiu, C., additional, Cinteza, M., additional, Vinereanu, D., additional, Lira, E., additional, Lebihan, D., additional, Monaco, C., additional, Ruiz Ortiz, M., additional, Mesa, D., additional, Delgado, M., additional, Romo, E., additional, Pena, M., additional, Puentes, M., additional, Santisteban, M., additional, Lopez Granados, A., additional, Arizon Del Prado, J., additional, Suarez De Lezo, J., additional, Tsai, W.-C., additional, Shih, J.-Y., additional, Huang, T.-S., additional, Liu, Y.-W., additional, Huang, Y.-Y., additional, Tsai, L.-M., additional, Cho, E., additional, Choi, K., additional, Kwon, B., additional, Kim, D., additional, Jang, S., additional, Park, C., additional, Jung, H., additional, Jeon, H., additional, Youn, H., additional, Kim, J., additional, Rieck, A. E., additional, Cramariuc, D., additional, Lonnebakken, M., additional, Lund, B., additional, Moceri, P., additional, Doyen, D., additional, Cerboni, P., additional, Ferrari, E., additional, Li, W., additional, Goncalves, S., additional, Vinhais De Sousa, G., additional, Almeida, A. G., additional, Hernandez Garcia, C., additional, De La Rosa Hernandez, A., additional, Arroyo Ucar, E., additional, Jorge Perez, P., additional, Barragan Acea, A., additional, Lacalzada Almeida, J., additional, Jimenez Rivera, J., additional, Duque Garcia, A., additional, Laynez Cerdena, I., additional, Arhipov, O., additional, Sumin, A. N., additional, Campens, L., additional, Renard, M., additional, Trachet, B., additional, Segers, P., additional, De Paepe, A., additional, De Backer, J., additional, Purvis, J. A., additional, Sharma, D., additional, Hughes, S. M., additional, Marek, D., additional, Vindis, D., additional, Kocianova, E., additional, Taborsky, M., additional, Yoon, H., additional, Kim, K., additional, Ahn, Y., additional, Chung, M., additional, Cho, J., additional, Kang, J., additional, Rha, W., additional, Ozcan, O., additional, Sezgin Ozcan, D., additional, Candemir, B., additional, Aras, M., additional, Dincer, I., additional, Atak, R., additional, Gianturco, L., additional, Turiel, M., additional, Atzeni, F., additional, Tomasoni, L., additional, Bruschi, E., additional, Epis, O., additional, Sarzi-Puttini, P., additional, Aggeli, C., additional, Poulidakis, E., additional, Felekos, I., additional, Sideris, S., additional, Dilaveris, P., additional, Gatzoulis, K., additional, Stefanadis, C., additional, Roszczyk, N., additional, Sobczak, M., additional, Peruga, J., additional, Krecki, R., additional, Kasprzak, J., additional, Ishii, K., additional, Suyama, T., additional, Kataoka, K., additional, Furukawa, A., additional, Nagai, T., additional, Maenaka, M., additional, Seino, Y., additional, Musca, F., additional, De Chiara, B., additional, Moreo, A., additional, Cataldo, S., additional, Parolini, M., additional, Parodi, O., additional, Bombardini, T., additional, Faita, F., additional, Park, S.-J., additional, Kil, J.-H., additional, Kim, S.-J., additional, Jang, S.-Y., additional, Chang, S.-A., additional, Choi, J.-O., additional, Lee, S.-C., additional, Park, S., additional, Park, P., additional, Oh, J., additional, Cikes, M., additional, Velagic, V., additional, Biocina, B., additional, Gasparovic, H., additional, Djuric, Z., additional, Bijnens, B., additional, Milicic, D., additional, Huqi, A., additional, Klas, B., additional, He, A., additional, Paterson, I., additional, Irween, M., additional, Ezekovitz, J., additional, Choy, J., additional, Chen, Y., additional, Cheng, L., additional, Yao, R., additional, Yao, H., additional, Chen, H., additional, Pan, C., additional, Shu, X., additional, Sobkowicz, B., additional, Kaminska, M., additional, Musial, W., additional, Buechel, R., additional, Sommer, G., additional, Leibundgut, G., additional, Rohner, A., additional, Bremerich, J., additional, Kaufmann, B., additional, Kessel-Schaefer, A., additional, Handke, M., additional, Kiotsekoglou, A., additional, Saha, S., additional, Toole, R., additional, Sharma, S., additional, Gopal, A., additional, Adhya, S., additional, Tsang, W., additional, Kenny, C., additional, Kapetanakis, S., additional, Lang, R., additional, Monaghan, M., additional, Smith, B., additional, Coulter, T., additional, Rendon, A., additional, Cheung, W.-S., additional, Gorissen, W., additional, Ejlersen, J. A., additional, May, O., additional, Van Slochteren, F. J., additional, Van Der Spoel, T., additional, Hanssen, H., additional, Doevendans, P., additional, Chamuleau, S., additional, De Korte, C., additional, Tarr, A., additional, Stoebe, S., additional, Trache, T., additional, Kluge, J.-G., additional, Varga, A., additional, Hagendorff, A., additional, Nagy, A., additional, Kovacs, A., additional, Apor, A., additional, Sax, B., additional, Becker, D., additional, Merkely, B., additional, Lindquist, R., additional, Miller, A., additional, Reece, C., additional, Eidem, B. W., additional, Choi, W.-G., additional, Kim, S., additional, Oh, S., additional, Kim, Y., additional, Iacobelli, R., additional, Chinali, M., additional, D' Asaro, M., additional, Toscano, A., additional, Del Pasqua, A., additional, Esposito, C., additional, Seghetti, G., additional, Parisi, F., additional, Pongiglione, G., additional, Rinelli, G., additional, Omaygenc, O., additional, Bakal, R., additional, Dogan, C., additional, Teber, K., additional, Akpinar, S., additional, Sahin, G., additional, Ozdemir, N., additional, Penhall, A., additional, Joseph, M., additional, Chong, F., additional, De Pasquale, C., additional, Selvanayagam, J., additional, Leong, D., additional, Nyktari, E. G., additional, Patrianakos, A. P., additional, Goudis, C., additional, Solidakis, G., additional, Parthenakis, F., additional, Vardas, P., additional, Nestaas, E., additional, Fugelseth, D., additional, Vitarelli, A., additional, Capotosto, L., additional, Bernardi, M., additional, Conde, Y., additional, Caranci, F., additional, Placanica, G., additional, Dettori, O., additional, Vitarelli, M., additional, De Chiara, S., additional, De Cicco, V., additional, Ferro', M., additional, Calabro', R., additional, Apostolakis, S., additional, Chalikias, G., additional, Tziakas, D., additional, Stakos, D., additional, Thomaidi, A., additional, Konstantinides, S., additional, Iorio, G., additional, Rucos, R., additional, Continanza, G., additional, D Ascanio, M., additional, Alessandroni, L., additional, Saponara, M., additional, Berry, M., additional, Nahum, J., additional, Zaghden, O., additional, Monin, J., additional, Couetil, J., additional, Lairez, O., additional, Macron, L., additional, Dubois Rande, J., additional, Gueret, P., additional, Lim, P., additional, Cameli, M., additional, Giacomin, E., additional, Lisi, M., additional, Benincasa, S., additional, Righini, F., additional, Menci, D., additional, Focardi, M., additional, Mondillo, S., additional, Philip, E., additional, Gorincour, G., additional, Bellsham-Revell, H., additional, Bell, A. J., additional, Miller, O. I., additional, Beerbaum, P., additional, Razavi, R., additional, Greil, G., additional, Simpson, J. M., additional, Ann, S., additional, Kim, T., additional, Lee, J., additional, Chin, J., additional, Cabeza Lainez, P., additional, Escolar Camas, V., additional, Gheorghe, L., additional, Fernandez Garcia, P., additional, Vazquez Garcia, R., additional, Caiulo, V., additional, Caiulo, S., additional, Fisicaro, A., additional, Moramarco, F., additional, Latini, G., additional, Seale, A., additional, Carvalho, J., additional, Gardiner, H., additional, Roughton, M., additional, Simpson, J., additional, Tometzki, A., additional, Uzun, O., additional, Webber, S., additional, Daubeney, P., additional, Dawood, A., additional, Dwivedi, G., additional, Mahadevan, G., additional, Jiminez, D., additional, Steeds, R., additional, Frenneaux, M., additional, Attenhofer Jost, C. H., additional, Knechtle, B., additional, Bernheim, A., additional, Pfyffer, M., additional, Linka, A., additional, Faeh-Gunz, A., additional, Seifert, B., additional, De Pasquale, G., additional, Zuber, M., additional, Tomaszewski, A., additional, Kutarski, A., additional, and Tomaszewski, M., additional

Published
2011
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4. CLOPIDOGREL VERSUS PRASUGREL EN SÍNDROME CORONARIO AGUDO TRATADO CON ANGIOPLASTIA.

Author

LALOR, NICOLAS, RODRÍGUEZ, LEANDRO, ELISSAMBURU, PABLO, FILIPINI, EDUARDO, CONDE, DIEGO, NAU, GERARDO, CURA, FERNANDO, and TRIVI, MARCELO

Abstract

Copyright of Medicina (Buenos Aires) is the property of Medicina (Buenos Aires) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2015

18. Limitations of apical sparing pattern in cardiac amyloidosis: a multicentre echocardiographic study.

Author

Cotella J, Randazzo M, Maurer MS, Helmke S, Scherrer-Crosbie M, Soltani M, Goyal A, Zareba K, Cheng R, Kirkpatrick JN, Yogeswaran V, Kitano T, Takeuchi M, Fernandes F, Hotta VT, Campos Vieira ML, Elissamburu P, Ronderos R, Prado A, Koutroumpakis E, Deswal A, Pursnani A, Sarswat N, Addetia K, Mor-Avi V, Asch FM, Slivnick JA, and Lang RM

Subjects
Humans, Female, Male, Middle Aged, Aged, Cardiomyopathies diagnostic imaging, Case-Control Studies, Ventricular Dysfunction, Left diagnostic imaging, Ventricular Dysfunction, Left physiopathology, Retrospective Studies, ROC Curve, Amyloidosis diagnostic imaging, Echocardiography methods
Abstract

Aims: Although impaired left ventricular (LV) global longitudinal strain (GLS) with apical sparing is a feature of cardiac amyloidosis (CA), its diagnostic accuracy has varied across studies. We aimed to determine the ability of apical sparing ratio (ASR) and most common echocardiographic parameters to differentiate patients with confirmed CA from those with clinical and/or echocardiographic suspicion of CA but with this diagnosis ruled out., Methods and Results: We identified 544 patients with confirmed CA and 200 controls (CTRLs) as defined above (CTRL patients). Measurements from transthoracic echocardiograms were performed using artificial intelligence software (Us2.AI, Singapore) and audited by an experienced echocardiographer. Receiver operating characteristic curve analysis was used to evaluate the diagnostic performance and optimal cut-offs for the differentiation of CA patients from CTRL patients. Additionally, a group of 174 healthy subjects (healthy CTRL) was included to provide insight on how patients and healthy CTRLs differed echocardiographically. LV GLS was more impaired (-13.9 ± 4.6% vs. -15.9 ± 2.7%, P < 0.0005), and ASR was higher (2.4 ± 1.2 vs. 1.7 ± 0.9, P < 0.0005) in the CA group vs. CTRL patients. Relative wall thickness and ASR were the most accurate parameters for differentiating CA from CTRL patients [area under the curve (AUC): 0.77 and 0.74, respectively]. However, even with the optimal cut-off of 1.67, ASR was only 72% sensitive and 66% specific for CA, indicating the presence of apical sparing in 32% of CTRL patients and even in 6% healthy subjects., Conclusion: Apical sparing did not prove to be a CA-specific biomarker for accurate identification of CA, when compared with clinically similar CTRLs with no CA., Competing Interests: Conflict of interest: None declared., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2024
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19. [Clopidogrel versus prasugrel in acute coronary syndrome treated with coronary angioplasty].

Author

Lalor N, Rodríguez L, Elissamburu P, Filipini E, Conde D, Nau G, Cura F, and Trivi M

Subjects
Acute Coronary Syndrome mortality, Angioplasty adverse effects, Clopidogrel, Female, Hemorrhage prevention & control, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Platelet Aggregation Inhibitors adverse effects, Prasugrel Hydrochloride adverse effects, Retrospective Studies, Ticlopidine adverse effects, Ticlopidine therapeutic use, Treatment Outcome, Acute Coronary Syndrome therapy, Angioplasty methods, Platelet Aggregation Inhibitors therapeutic use, Prasugrel Hydrochloride therapeutic use, Stents, Ticlopidine analogs & derivatives
Abstract

Greater antithrombotic potency new antiplatelet agents have been added such as prasugrel (PR) and ticagrelor to the traditional use of clopidogrel (CL) in the treatment of acute coronary syndrome (ACS). This study was aimed at comparing the incidence of long term ischemic and hemorrhagic events in patients treated with CL or PR during hospitalization. Retrospective ACS data base analysis performed by our cardiology service was completed prospectively. There were consecutively included all patients with percutaneous coronary intervention (PCI) during hospitalization due to ACS from December 2011 thru December 2012. A total of 398 ACS patients who underwent PCI with stent implantation were recruited. No differences in cardiovascular related deaths were observed in both groups (PR 2.9% vs. CL 2.5%, p=0.48). PR group showed less re-infraction (1.9% vs. 6.8%, p=0.01) with more total bleedings (18.5% vs. 8.5%, p=0.001) and minor bleedings (12.4% vs. 3.4%, p<0.001) with no differences in major and life threatening bleedings (p=ns). Multivariate analysis showed that independent predictors of cardiovascular mortality were age (OR 1.08, CI 95% 1.02-1.16) and renal failure (OR 6.98, CI 95% 1.23-39.71). Independent predictors for total bleeding were age (OR 1.06, CI 95% 1.02-1.09),ST segment elevation myocardial infarction (OR 1.99, CI 95% 1.05-3.79), renal failure (OR 3.32, CI 95% 1.62-6.78) and prasugrel use (OR 3.97, CI 95% 1.87-8.41). Use of prasugrel, in the ACS that requires PCI with stent, is associated with a lower myocardial infarction a year after follow-up, and it also leads to an increase of milder hemorrhage. No significant differences were observed in the cardiovascular mortality of both groups.

Published
2015

21. Conversion of Recent-Onset Atrial Fibrillation: Which Drug is the Best?

Author

Conde D, Elissamburu P, Lalor N, Rodriguez L, Aragon M, Costabel JP, Lambardi F, and Trivi M

Abstract

Introduction: Vernakalant is a new, safe and effective drug used intravenously. It has proven to be more rapid in converting recent onset atrial fibrillation (AF) to sinus rhythm compared to placebo, amiodarone, propafenone and flecainide in clinical studies with few patients. At present no study has been conducted comparing these three drugs with a more substantial number of patients. The aim of our study is to compare the time to conversion to sinus rhythm, hospital stay and adverse events between vernakalant versus flecainide and propafenone in patients with a recent-onset AF. Materials and Methods: 150 hemodynamically stable patients with recent onset AF without structural heart disease were prospectively included. A single oral dose of propafenone 600 mg was administered to 50 patients; 50 patients received intravenous vernakalant; and 50 patients received a single oral dose of flecainide 300 mg. Clinical and laboratory variables were recorded. Results: Baseline characteristics were similar in the three groups.Time to conversion to sinus rhythm was 12 minutes in the vernakalant group versus 151 minutes in the propafenone group and 162 minutes in flecainide group (p< 0.01) The hospital stay was 243 minutes in the vernakalant group versus 422 minutes in the propafenone group and 410 minutes in flecainide group (p<0.01) (Figure 2). No adverse events were reported. Conclusion: The time to conversion to sinus rhythm and hospital stay were statistically shorter in vernakalant group compared to flecainide and to propafenone. There were no adverse events in the three groups.

Published
2013
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