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Your search keyword '"Elizabeth Viriya"' showing total 3 results
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3 results on '"Elizabeth Viriya"'

1. Expert Performance in Visual Differentiation of Bacterial and Fungal Keratitis

Author

Phit Upaphong, Manoj Vasudevan, Naveen Rao, Nakul Shekhawat, Mohamed Elghobaier, Napaporn Tananuvat, Sayali Pradhan, Suvitha Selvaraj, Vishal Jhanji, Diana Alvarez-Melloni, John K G Dart, Mohammad H. Dastjerdi, Menen Ayalew, Alan Sugar, Chris Estopinal, Vasudha Panday, Gerami D. Seitzman, Sonal S. Tuli, Jodhbir S. Mehta, Camila Kase, Michael Mimouni, Neha Shaik, Tyson Kim, Stephen D. McLeod, Brandon J. Lujan, Muthiah Srinivasan, Tanya Trinh, Nisha R. Acharya, Matilda Chan, Anna Hovakimyan, Prajna Lalitha, Elsie Chan, Y.Y. Choong, J. Peter Campbell, Joseph G. Christenbury, David Spokes, Bart T.H. van Dooren, Josephine Christy, Christine Martinez, Ruti Sella, Divya Karthik, Maria A. Woodward, Afshan A. Nanji, Nikhil Gokhale, Ashwin Balasubramanian, Audrey Talley Rostov, Faris Karas, Nathan Nataneli, Revathi Rajaraman, Meenu Chaudhary, N. Venkatesh Prajna, Rafael Martínez-Costa, Jeremy D. Keenan, David Liang, Ying Qian, Preethika Gandhi, Thomas M. Lietman, Tiru Krishnan, Sathish Devarajan, Aaleya Koreishi, Anitha Venugopal, Matthew Denny, Colleen Halfpenny, David G. Hwang, Elizabeth Viriya, Jennifer Rose-Nussbaumer, Rossen M Hazarbassanov, Thomas Chia, Adam Moss, Travis Redd, John Clements, Natalie Hernandez, Julie M. Schallhorn, Tomas Jaeschke, James Chodosh, Frank S. Hwang, Chulaluck Tangmonkongvoragul, and Lakshmi Kattana

Subjects
medicine.medical_specialty, education, Expert Systems, Diagnostic Techniques, Ophthalmological, Infectious Keratitis, Article, Eye Infections, Bacterial, Cornea, Diagnosis, Differential, Ophthalmology, medicine, Humans, Fungal keratitis, Corneal Ulcer, Reference standards, Bacteria, business.industry, Fungi, Bacterial keratitis, corneal ulcer, medicine.disease, medicine.anatomical_structure, ROC Curve, Area Under Curve, business, Eye Infections, Fungal, Specialization
Abstract

This study quantifies the performance of an international cohort of cornea specialists in image-based differentiation of bacterial and fungal keratitis, identifying significant regional variation and establishing a reference standard for comparison against machine learning models.

Published
2022

2. Postrefractive infectious keratitis: prevention, diagnosis, management, and prognosis

Author

Elizabeth Viriya and Francis S. Mah

Subjects
Keratitis, medicine.medical_specialty, business.industry, Disease Management, General Medicine, Infectious Keratitis, Prognosis, Refractive Errors, Eye Infections, Bacterial, 03 medical and health sciences, Ophthalmology, 0302 clinical medicine, Causative organism, Anti-Infective Agents, Diagnosis management, 030221 ophthalmology & optometry, medicine, Humans, Surgical Wound Infection, Identification (biology), Intensive care medicine, business, Complication, Empiric therapy, 030217 neurology & neurosurgery
Abstract

PURPOSE OF REVIEW Improve outcomes from an elective procedure by preventing a rare but sight-threatening complication. RECENT FINDINGS Advancement in anti-infective prophylaxis, and therefore shift in the causative organism permits better diagnostic and empiric management. SUMMARY Infectious keratitis presents in different patterns depending on the refractive procedure. Atypical causative organisms may respond poorly to empiric therapy and impair vision. Therefore, microbial identification is of utmost importance and therapy is adjusted accordingly.

Published
2021

3. Retinoids as ligands and coactivators of protein kinase C alpha

Author

Beatrice Hoyos, Elizabeth Viriya, Asiya Imam, Ulrich Hämmerling, Ester Levi, Ramon Chua, and Christina Swenson

Subjects
Vitamin, Protein Kinase C-alpha, MAP Kinase Signaling System, Mitogen-activated protein kinase kinase, Biology, Ligands, Biochemistry, Models, Biological, chemistry.chemical_compound, Mice, Retinoids, Genetics, medicine, Animals, ASK1, c-Raf, Cysteine, Binding site, Vitamin A, Molecular Biology, Protein kinase C, Protein Kinase C, Binding Sites, MAP kinase kinase kinase, Dose-Response Relationship, Drug, 3T3 Cells, Hydrogen Peroxide, medicine.disease, Cell biology, Protein Structure, Tertiary, Vitamin A deficiency, Enzyme Activation, Isoenzymes, chemistry, Diterpenes, Reactive Oxygen Species, Oxidation-Reduction, Biotechnology, Protein Binding
Abstract

Whereas retinoic acids control nuclear events, a second class of retinol metabolites, that is, the hydroxylated forms exemplified by 14-hydroxy-retro-retinol (HRR), operate primarily in the cytoplasm. They function as regulatory cofactors for cell survival/cell death decisions. In accordance with these biological aspects, we demonstrate that these retinoids bound protein kinase C (PKC) alpha with nanomolar affinity and markedly enhance the activation of PKC alpha and the entire downstream MAP kinase pathway by reactive oxygen species. HRR was 10 times more efficient than retinol, and the optimum doses are 10-7 and 10-6 M, respectively. PKC alpha activation was reversed rapidly by imposition of reducing conditions. The retinoid binding site was mapped to the first cysteine-rich region in the regulatory domain, C1A, yet was distinct from the binding sites of diacylglycerol and phorbol esters. The C1B domain bound retinoids poorly. The emerging theme is that retinoids serve as redox regulators of protein kinase C.

Published
2000

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