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21 results on '"Elkind, Jaclynn"'

1. Head Injury Treatment With Healthy and Advanced Dietary Supplements: A Pilot Randomized Controlled Trial of the Tolerability, Safety, and Efficacy of Branched Chain Amino Acids in the Treatment of Concussion in Adolescents and Young Adults

Author

Corwin, Daniel J., primary, Myers, Sage R., additional, Arbogast, Kristy B., additional, Lim, Miranda M., additional, Elliott, Jonathan E., additional, Metzger, Kristina B., additional, LeRoux, Peter, additional, Elkind, Jaclynn, additional, Metheny, Hannah, additional, Berg, Jeffrey, additional, Pettijohn, Kevin, additional, Master, Christina L., additional, Kirschen, Matthew P., additional, and Cohen, Akiva S., additional

Published
2024
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5. A Cross-sectional fMRI Study of Risk Factors of Obesity in Emerging Adult Women and the Moderating Role of Childhood Maltreatment

Author

Elkind, Jaclynn and Elkind, Jaclynn

Abstract

Background: Obesity is a prevalent public health issue and affects more than 40 percent of adults in the United States. Women are more likely to be classified as obese than men, and are more likely to report disordered eating behaviors, particularly in young adulthood. Early life stressors, such as child maltreatment, can impact brain development in the areas related to decision-making and reward-driven behaviors like eating, which may contribute to the growing obesity epidemic. Neurobiological studies have shown that individuals who exhibit greater neural reactivity to highly palatable, rewarding foods who have poor impulse control may be more likely to engage in hedonic eating. This may be more pronounced in people with experiences of childhood maltreatment. Methods: This dissertation will: 1) systematically review the relationship between childhood maltreatment and disordered eating in emerging adult women; 2) assess the relationship between hedonic hunger and neural responses to food cues; and 3) evaluate the relationship between impulsivity and neural responses to food cues. A moderation analysis will explore if the relationship between the neural response to food cues and hedonic hunger/impulsivity are strengthened by experiences of childhood maltreatment. A secondary data analysis was performed on a sample of emerging adult (18-24 years) women who participated in a two-day study using survey measures and functional magnetic resonance imaging to evaluate hedonic hunger, impulsivity and experiences of childhood maltreatment, and to measure how the brain responds to passive observation of visual food cues. Results: Analysis of the literature revealed an association between experiences of childhood maltreatment and disordered eating behaviors in emerging adult women. Analysis of the fMRI data demonstrated differences in neural response to novel and repeated cues was associated with hedonic hunger, but not impulsivity in areas associated with executive control and

Published
2020

8. An Evidence-Based Framework for Implementation of a School–Community Partnership.

Author

McCabe, Ellen M., Kaskoun, Jeannine R., Murphy, Eleanor L., Polkinghorn, Madeline, and Elkind, Jaclynn A.

Subjects
PUBLIC relations, ASTHMA, EVIDENCE-based medicine, HUMAN services programs
Abstract

School–community partnerships (SCPs) are collaborative efforts between schools and community organizations geared toward improving the health of school-age children through care coordination. These partnerships are ideal for youth with acute and chronic illness because they can implement evidence-based interventions and offer skills and education to support youth self-management and academic success. Utilizing the chronic condition of asthma as an exemplar, this article highlights several successful SCPs and how they are mutually beneficial to both the school and community. Additionally, this article offers strategies for stakeholders, including school nurses, to establish an SCP. SCPs lay the foundation for supporting community- and school-based health and lend themselves to a healthier future for youth. [ABSTRACT FROM AUTHOR]

Published
2021
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11. Brain Injury Alters Volatile Metabolome

Author

Kimball, Bruce A., primary, Cohen, Akiva S., additional, Gordon, Amy R., additional, Opiekun, Maryanne, additional, Martin, Talia, additional, Elkind, Jaclynn, additional, Lundström, Johan N., additional, and Beauchamp, Gary K., additional

Published
2016
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15. 108

Author

Kirschen, Matthew, primary, Elkind, Jaclynn, additional, Lim, Miranda, additional, Putnam, Brendan, additional, and Cohen, Akiva, additional

Published
2014
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16. Traumatic Brain Injury-Induced Ependymal Ciliary Loss Decreases Cerebral Spinal Fluid Flow

Author

Xiong, Guoxiang, primary, Elkind, Jaclynn A., additional, Kundu, Suhali, additional, Smith, Colin J., additional, Antunes, Marcelo B., additional, Tamashiro, Edwin, additional, Kofonow, Jennifer M., additional, Mitala, Christina. M., additional, Cole, Jeffrey, additional, Stein, Sherman C., additional, Grady, M. Sean, additional, Einhorn, Eugene, additional, Cohen, Noam A., additional, and Cohen, Akiva S., additional

Published
2014
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21. Dietary branched chain amino acids ameliorate injury-induced cognitive impairment.

Author

CoIe, Jeffrey T., Mitala, Christina M., Kundu, Suhali, Verma, Ajay, Elkind, Jaclynn A., Nissim, Itzhak, and Cohen, Akiva S.

Subjects
BRANCHED chain amino acids, AMINO acids in human nutrition, COGNITION disorders, BRAIN injuries, AMINOTRANSFERASES, DEHYDROGENASES, GLUTAMATE decarboxylase
Abstract

Neurological dysfunction caused by traumatic brain injury results in profound changes in net synaptic efficacy, leading to impaired cognition. Because excitability is directly controlled by the balance of excitatory and inhibitory activity, underlying mechanisms causing these changes were investigated using lateral fluid percussion brain injury in mice. Although injury-induced shifts in net synaptic efficacy were not accompanied by changes in hippocampal glutamate and GABA levels, significant reductions were seen in the concentration of branched chain amino acids (BCAAs), which are key precursors to de novo glutamate synthesis. Dietary consumption of BCAAs restored hippocampal BCAA concentrations to normal, reversed injury-induced shifts in net synaptic efficacy, and led to reinstatement of cognitive performance after concussive brain injury. All brain-injured mice that consumed BCAAs demonstrated cognitive improvement with a simultaneous restoration in net synaptic efficacy. Posttraumatic changes in the expression of cytosolic branched chain aminotransferase, branched chain ketoacid dehydrogenase, glutamate dehydrogen- ase. and glutamic acid decarboxylase support a perturbation of BCAA and neurotransmitter metabolism. Ex vivo application of BCAAs to hippocampal slices from injured animals restored post-traumatic regional shifts in net synaptic efficacy as measured by field excitatory postsynaptic potentials. These results suggest that dietary BCAA intervention could promote cognitive improvement by restoring hippocampal function after a traumatic brain injury. [ABSTRACT FROM AUTHOR]

Published
2010

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