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2 results on '"Ellen L Hamburg"'

1. Overdose of risperidone

Author

Ken Brown, Cynthia Brenner, Ellen L Hamburg, Howard Levy, and Stephen Leffler

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, medicine.medical_treatment, Poison control, Suicide, Attempted, Suicide prevention, Electrocardiography, Antipsychotic Agent, Piperidines, medicine, Humans, Antipsychotic, Risperidone, Suicide attempt, business.industry, Poisoning, Dopamine antagonist, Isoxazoles, Risperidone overdose, Anesthesia, Emergency Medicine, business, medicine.drug, Antipsychotic Agents
Abstract

Risperidone is an investigational antipsychotic agent currently being tested in an international multicenter drug trial. We report the first case of a risperidone overdose in an apparent suicide attempt. This was without serious clinical side effects and manifested mainly as ECG abnormalities.

Published
1993

2. GLC Determination of Quinidines in Human Plasma

Author

Patricia Driscoll, Everett D. Thompson, Jimmie L. Valentine, and Ellen L. Hamburg

Subjects
Quinidine, Chromatography, Gas, Chromatography, Pharmaceutical Science, Cinchonine, Chloride, chemistry.chemical_compound, Residue (chemistry), Drug Stability, chemistry, Human plasma, Present method, medicine, Humans, Hydroxide, Chromatography, Thin Layer, Methylene, medicine.drug
Abstract

Human plasma was made alkaline and extracted with methylene chloride. To the extract was added the internal standard, cinchonine, followed by evaporation to dryness. The resultant residue was dissolved in a methanolic solution containing trimethylanilinium hydroxide. This solution was assayed by GLC for quinidines (quinidine and hydroquinidine). Evaluation of the method over a 0.5–10‐μg/ml range in human plasma gave an overall precision and accuracy of ±4.5% ( RSD and RE ). Plasma of several patients was analyzed by the present method as well as by a fluorometric method for the level of quinidines. Results from the two methods were comparable.

Published
1976
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