Search

Your search keyword '"Ellinghaus, Ursula"' showing total 9 results
Start Over Author "Ellinghaus, Ursula"
9 results on '"Ellinghaus, Ursula"'

1. Preclinical efficacy and pharmacokinetics of an RNA-encoded T cell–engaging bispecific antibody targeting human claudin 6

Author

Stadler, Christiane R., primary, Ellinghaus, Ursula, additional, Fischer, Leyla, additional, Bähr-Mahmud, Hayat, additional, Rao, Martin, additional, Lindemann, Claudia, additional, Chaturvedi, Anuhar, additional, Scharf, Caroline, additional, Biermann, Imke, additional, Hebich, Bernhard, additional, Malz, Alexandra, additional, Beresin, Georg, additional, Falck, Georg, additional, Häcker, Aline, additional, Houben, Astrid, additional, Erdeljan, Michael, additional, Wolf, Kristina, additional, Kullmann, Maximilian, additional, Chang, Philip, additional, Türeci, Özlem, additional, and Şahin, Uğur, additional

Published
2024
Full Text
View/download PDF

2. Preclinical characterization of an mRNA-encoded anti-Claudin 18.2 antibody

Author

Bähr-Mahmud, Hayat, primary, Ellinghaus, Ursula, additional, Stadler, Christiane R., additional, Fischer, Leyla, additional, Lindemann, Claudia, additional, Chaturvedi, Anuhar, additional, Diekmann, Jan, additional, Wöll, Stefan, additional, Biermann, Imke, additional, Hebich, Bernhard, additional, Scharf, Caroline, additional, Siefke, Manuela, additional, Roth, Alexandra S., additional, Rao, Martin, additional, Brettschneider, Kerstin, additional, Ewen, Eva-Maria, additional, Şahin, Uğur, additional, and Türeci, Özlem, additional

Published
2023
Full Text
View/download PDF

5. Dysregulated CD46 shedding interferes with Th1-contraction in systemic lupus erythematosus

Author

Ellinghaus, Ursula, Cortini, Andrea, Pinder, Christopher L., Le Friec, Gaelle, Kemper, Claudia, and Vyse, Timothy J.

Subjects
Adult, Male, T-Lymphocytes, viruses, Immunology, Complement, Autoimmunity, Matrix Metalloproteinase Inhibitors, Th1, ACTIVATION, Membrane Cofactor Protein, Clinical, Journal Article, Humans, Lupus Erythematosus, Systemic, NOTCH PATHWAY, CD46, Complement Activation, Research Articles, ELEVATED SERUM, Innate immunity, B-Lymphocytes, Science & Technology, IFN-GAMMA, Research Article|Clinical, T cell, MULTIPLE-SCLEROSIS, Th1 Cells, Immunity, Innate, female genital diseases and pregnancy complications, Interleukin-10, Immunodeficiencies and autoimmunity, Matrix Metalloproteinase 9, 1107 Immunology, T-CELLS, Female, Life Sciences & Biomedicine, RESPONSES, Signal Transduction
Abstract

IFN-γ-producing T helper 1 (Th1) cell responses mediate protection against infections but uncontrolled Th1 activity also contributes to a broad range of autoimmune diseases. Autocrine complement activation has recently emerged as key in the induction and contraction of human Th1 immunity: Activation of the complement regulator CD46 and the C3aR expressed by CD4(+) T cells via autocrine generated ligands C3b and C3a, respectively, are critical to IFN-γ production. Further, CD46-mediated signals also induce co-expression of immunosuppressive IL-10 in Th1 cells and transition into a (self)-regulating and contracting phase. In consequence, C3 or CD46-deficient patients suffer from recurrent infections while dysregulation of CD46 signalling contributes to Th1 hyperactivity in rheumatoid arthritis and multiple sclerosis. Here, we report a defect in CD46-regulated Th1 contraction in patients with systemic lupus erythematosus (SLE). We observed that MMP-9-mediated increased shedding of soluble CD46 by Th1 cells was associated with this defect and that inhibition of MMP-9 activity normalized release of soluble CD46 and restored Th1 contraction in patients' T cells. These data may deliver the first mechanistic explanation for the increased serum CD46 levels observed in SLE patients and indicate that targeting CD46-cleaving proteases could be a novel avenue to modulate Th1 responses. This article is protected by copyright. All rights reserved.

Published
2017

7. A phase I/II dose escalation trial with expansion cohorts to evaluate safety and preliminary efficacy of BNT142 in patients with prospectively confirmed claudin 6-positive solid tumors.

Author

Yap, Timothy A., Papadopoulos, Kyriakos P., Garralda, Elena, Spira, Alexander I., Calvo, Emiliano, Saavedra, Omar, Ramon-Patino, Jorge L, Stadler, Christiane, Koseoglu, Secil, Chang, Philip K, Ellinghaus, Ursula, Lindemann, Claudia, Ewen, Eva-Maria, Zyto, Elzbieta, Zamorski, Alexandra, Martinez, Jorge Luis, De Mattos-Arruda, Leticia, Celik, Ilhan, Türeci, Özlem, and Sahin, Ugur

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results