36 results on '"Ellison, Amanda"'
Search Results
2. Event-related Repetitive TMS Reveals Distinct, Critical Roles for Right OFA and Bilateral Posterior STS in Judging the Sex and Trustworthiness of Faces.
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Dzhelyova, Milena P., Ellison, Amanda, and Atkinson, Anthony P.
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FACIAL muscles , *MUSCLE motility , *EVOKED potentials (Electrophysiology) , *RELIABILITY (Personality trait) , *TRANSCRANIAL magnetic stimulation , *JUDGMENT (Logic) , *NEURAL transmission - Abstract
Judging the sex of faces relies on cues related to facial morphology and spatial relations between features, whereas judging the trustworthiness of faces relies on both structural and expressive cues that signal affective valence. The right occipital face area (OFA) processes structural cues and has been associated with sex judgments, whereas the posterior STS processes changeable facial cues related to muscle movements and is activated when observers judge trustworthiness. It is commonly supposed that the STS receives inputs from the OFA, yet it is unknown whether these regions have functionally dissociable, critical roles in sex and trustworthiness judgments. We addressed this issue using event-related, fMRI-guided repetitive transcranial magnetic stimulation (rTMS). Twelve healthy volunteers judged the sex of individually presented faces and, in a separate session, whether those same faces were trustworthy or not. Relative to sham stimulation, RTs were significantly longer for sex judgments when rTMS was delivered over the right OFA but not the right or left STS, and for trustworthiness judgments on male but not female faces when rTMS was delivered over the right STS or left STS but not the right OFA. Nonetheless, an analysis of the RT distributions revealed a possible critical role also for the right OFA in trustworthiness judgments, limited to faces with longer RTs, perhaps reflecting the later, ancillary use of structural cues related to the sex of the face. On the whole, our findings provide evidence that evaluations of the trustworthiness and sex of faces rely on functionally dissociable cortical regions. [ABSTRACT FROM AUTHOR]
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- 2011
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3. Differential and co-involvement of areas of the temporal and parietal streams in visual tasks
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Ellison, Amanda and Cowey, Alan
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TEMPORAL lobe , *PARIETAL lobe , *VISUAL pathways , *TRANSCRANIAL magnetic stimulation , *TEASING , *VISUAL cortex , *VISUAL discrimination , *NEUROPSYCHOLOGY - Abstract
Abstract: Transcranial magnetic stimulation (TMS) is particularly useful in teasing apart the contrasting contributions of different anatomical and functional systems in particular aspects of behaviour, for example the involvement of the dorsal and ventral visual streams in tasks involving the perception of distance, shape and colour. In order to investigate the dual involvement of two areas, namely right posterior parietal cortex (PPC) and lateral occipital cortex (LO), in a distance discrimination task, neural processing in both areas was concurrently disrupted using dual site TMS. Although there was no change in error rates, reaction time was significantly lengthened over that seen with TMS over either site alone. This additive effect indicates that both PPC and LO are concurrently active and essential for efficient processing of this task. The second experiment investigated the specificity of function within the ventral stream. Performance was assessed for distance and shape discrimination when TMS was applied to our original LO site and an area rostral to V5 but still part of the lateral occipital complex (rostral LOC) that is activated in form and colour discrimination. Performance deficits were restricted to TMS over LO; no significant impairment for either task followed TMS at the rostral LOC site. [Copyright &y& Elsevier]
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- 2009
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4. Time course of the involvement of the ventral and dorsal visual processing streams in a visuospatial task
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Ellison, Amanda and Cowey, Alan
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VISUAL perception , *TRANSCRANIAL magnetic stimulation , *BRAIN research , *EVOKED potentials (Electrophysiology) - Abstract
Abstract: A previous transcranial magnetic stimulation (TMS) study [Ellison, A., & Cowey, A. (2006). TMS can reveal contrasting functions of the dorsal and ventral visual processing streams. Experimental Brain Research, 175, 618–625] showed that both the dorsal and ventral cortical visual processing streams are involved in the processing of a task in which judgement of relative spatial position is required. In order to determine whether both streams are active in a parallel or serial manner, a double pulse TMS (20Hz) experiment was carried out to expose peaks of disruption, indicative of when each of the areas under investigation is most potently involved. Results show that TMS over lateral occipital cortex produces greater disruption of performance than that provoked by TMS over posterior parietal cortex, significantly so when applied at 50 and 100ms post-visual array onset. Both areas showed peaks of disruption up to 350ms after visual stimulus onset. The results are discussed with respect to why each of these areas is involved in this task and what the pattern of their involvement reveals. [Copyright &y& Elsevier]
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- 2007
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5. TMS can reveal contrasting functions of the dorsal and ventral visual processing streams.
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Ellison, Amanda and Cowey, Alan
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TRANSCRANIAL magnetic stimulation , *VISUAL perception , *VISUAL discrimination , *VISION , *BRAIN stimulation - Abstract
In order to investigate the functional specificity of the dorsal and ventral visual processing steams we used transcranial magnetic stimulation (TMS) to briefly disrupt one or the other while subjects performed three tasks, involving discrimination of colour or shape or relative position. TMS was delivered over right posterior parietal cortex (PPC) or right lateral occipital (LO) cortex, regions known to have visuo-spatial and object processing properties respectively. LO but not PPC stimulation had a significant effect on reaction time when subjects were asked to make a discrimination of relative shape. PPC stimulation had a significant effect when subjects were asked to discriminate relative position of the same shapes. Stimulation of LO also lengthened reaction times on the position task. There were no effects of stimulation at either site on colour discrimination. Results are discussed within the framework of how the dorsal stream and ventral stream are dissociated following their damage in neurological patients and possible ways in which they may interact in the normal brain. [ABSTRACT FROM AUTHOR]
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- 2006
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6. The role of V5/MT+ in the control of catching movements: an rTMS study
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Schenk, Thomas, Ellison, Amanda, Rice, Nichola, and Milner, A. David
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BRAIN , *CENTRAL nervous system , *BRAIN diseases , *BRAIN research - Abstract
Abstract: Milner and Goodale [Milner, A. D., & Goodale, M. A. (1995). The visual brain in action. Oxford: Oxford University Press] described a model which distinguishes between two visual streams in the brain. It is claimed that the ventral stream serves object recognition (i.e. vision for perception), and the dorsal streams provides visual information for the guidance of action (i.e. vision for action). This model is supported by evidence from the domain of spatial vision, but it remains unclear how motion vision fits into that model. More specifically, it is unclear how the motion complex V5/MT contributes to vision for perception and vision for action. We addressed this question in an earlier study with the V5-lesioned patient LM [Schenk, T., Mai, N., Ditterich, J., & Zihl, J. (2000). Can a motion-blind patient reach for moving objects? European Journal of Neuroscience, 12, 3351–3360]. We found that she is not only impaired in perceptual tasks but also in catching, suggesting a role for V5/MT+ in vision for both perception and action. However, LM''s lesion goes beyond V5/MT+ into more dorsal regions. It is thus possible, that the catching deficit was not produced by damage to V5/MT+ itself. In this case, one would expect that selective interference with V5/MT+ would have no effect on catching. In the present study we tested this prediction by applying rTMS over V5/MT+ of the left hemisphere while healthy subjects were either performing a catching or a reaching task. We found that V5-TMS reduced the speed of the catching but not the reaching response. These results confirm that V5/MT+ is not only involved in perceptual but also in visuomotor tasks. [Copyright &y& Elsevier]
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- 2005
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7. The effect of expectation on facilitation of colour/form conjunction tasks by TMS over area V5
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Ellison, Amanda, Battelli, Lorella, Cowey, Alan, and Walsh, Vincent
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TRUTH maintenance systems , *VISUAL cortex , *EYE movement disorders , *COLOR - Abstract
In an earlier paper, we reported task-specific impairments and improvements caused by applying TMS over cortical visual area V5 [Proceedings of the Royal Society of London B 265 (1998) 537]. The phenomenon is further investigated in the present study using two of the previous tasks: a motion/form conjunction in which TMS impaired performance and a colour/form conjunction in which performance was enhanced with TMS. In the earlier experiment, subjects were presented with blocks of trials of one task type perhaps allowing some of the observed effects to arise from knowing the type of stimulus to be discriminated. When blocks of trials consisted of randomly mixed moving/form and colour/form conjunction tasks, TMS over V5 still impaired target-present responses for the moving/form conjunction, but the facilitation seen for colour/form conjunction target-present responses disappeared. We suggest that the competitive inhibition postulated between visual movement areas and colour areas in the brain, in our previous paper, are subject to expectation or knowledge of forthcoming stimulus type. [Copyright &y& Elsevier]
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- 2003
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8. The cortical representation of centrally presented words: A magnetic stimulation study.
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Lavidor, Michal, Ellison, Amanda, and Walsh, Vincent
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VISUAL cortex , *VISUAL perception , *MAGNETOTHERAPY , *CEREBRAL cortex - Abstract
The right and left visual fields each project to the contralateral cerebral hemispheres. The current study aimed to investigate the extent of the functional overlap of the two hemifields along the vertical meridian. We applied repetitive transcranial magnetic stimulation (rTMS) over the left and right occipital cortex to investigate whether the foveal representation of words is bilaterally represented or is split between the two hemispheres. Employing a lateralized lexical decision task, we first showed a double dissociation between the stimulated cortical site and performance; right visual field (RVF) but not left visual field (LVF) performance was impaired when the left visual cortex was stimulated, and LVF but not RVF performance was impairred when the right visual cortex was stimulated. Unilateral stimulation also significantly impaired lexical decision latencies to centrally presented words. These findings support the suggestion that foveal representation of words is split. We discuss future strategies for the use of TMS in further tests of the split representation account. [ABSTRACT FROM AUTHOR]
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- 2003
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9. Complementary localization and lateralization of orienting and motor attention.
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Rushworth, Matthew F. S., Ellison, Amanda, and Walsh, Vincent
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ORIENTATION physiology , *PARIETAL lobe - Abstract
It is widely agreed that the right posterior parietal cortex has a preeminent role in visuospatial and orienting attention. A number of lines of evidence suggest that although orienting and the preparation of oculomotor responses are dissociable from each other, the two are intimately related. If this is true, then it should be possible to identify other attentional mechanisms tied to other response modalities. We used repetitive transcranial magnetic stimulation (rTMS) to demonstrate the existence of a distinct anterior parietal mechanism of motor attention. The critical area for motor attention is anterior to the one concerned with orienting, and it is lateralized to the left hemisphere in humans. [ABSTRACT FROM AUTHOR]
- Published
- 2001
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10. Visual field asymmetries in attention and learning.
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Ellison, Amanda and Walsh, Vincent
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VISUAL perception , *PERCEPTUAL learning - Abstract
It has been suggested that attentional resolution is greater in the lower than in the upper visual lfield. As there is no corresponding asymmetry between the areas in the primary visual cortex where the input from upper and lower visual fields is processed, an 'attentional filter' has been proposed to act in one or more higher visual cortical areas in order to constrict the availability of visual information to the level of awareness. To investigate this, a visual search array was presented to the entire visual field and reaction times from upper and lower visual fields compared. In a second experiment, subjects were trained in detecting targets in different visual fields. There was no significant difference between reaction times for targets presented in either upper or lower visual fields when the array was presented to the entire visual field. However, when the array was restricted to either the upper or lower visual fields, reaction times were significantly slower for detection in the upper visual field. [ABSTRACT FROM AUTHOR]
- Published
- 2001
11. The effects of induced optical blur on visual search performance and training.
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Musa, Azuwan, Lane, Alison R, and Ellison, Amanda
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VISUAL perception , *VISUAL acuity , *VISION , *VISUAL training , *VISUAL fields , *PERCEPTUAL learning - Abstract
Visual search is a task often used in the rehabilitation of patients with cortical and non-cortical visual pathologies such as visual field loss. Reduced visual acuity is often comorbid with these disorders, and it remains poorly defined how low visual acuity may affect a patient's ability to recover visual function through visual search training. The two experiments reported here investigated whether induced blurring of vision (from 6/15 to 6/60) in a neurotypical population differentially affected various types of feature search tasks, whether there is a minimal acceptable level of visual acuity required for normal search performance, and whether these factors affected the degree to which participants could improve with training. From the results, it can be seen that reducing visual acuity did reduce search speed, but only for tasks where the target was defined by shape or size (not colour), and only when acuity was worse than 6/15. Furthermore, searching behaviour was seen to improve with training in all three feature search tasks, irrespective of the degree of blurring that was induced. The improvement also generalised to a non-trained search task, indicating that an enhanced search strategy had been developed. These findings have important implications for the use of visual search as a rehabilitation aid for partial visual loss, indicating that individuals with even severe comorbid blurring should still be able to benefit from such training. [ABSTRACT FROM AUTHOR]
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- 2022
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12. Uncovering the social determinants of brain injury rehabilitation.
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Dunne, Stephen, Williams, Glenn P, Bradbury, Chloe, Keyes, Tamsin, Lane, Alison R, Yang, Keming, and Ellison, Amanda
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WELL-being , *AFFINITY groups , *SOCIAL determinants of health , *SOCIAL support , *CONFIDENCE intervals , *RESEARCH methodology , *INTERVIEWING , *EXPERIENCE , *SOCIAL isolation , *COMPARATIVE studies , *LONELINESS , *QUESTIONNAIRES , *DESCRIPTIVE statistics , *STAY-at-home orders , *HEALTH equity , *THEMATIC analysis , *DATA analysis software , *COVID-19 pandemic , *REHABILITATION for brain injury patients , *PSYCHOLOGICAL resilience - Abstract
Social determinants of health (SDH), such as social isolation and loneliness, are often more frequently experienced in brain injury survivors. The paper explores the personal experiences of loneliness among brain injury survivors during lockdown to negate health inequalities and improve rehabilitation for this population in the future. Twenty-four brain injury survivors participated in semi-structured interviews and questionnaires relating to loneliness, resilience and wellbeing. Three themes (the experience of loneliness, loneliness during the pandemic and loneliness after the pandemic) explored survivors' experiences of loneliness generally post-brain injury, but also chronicle how these feelings developed in lockdown and survivors' feelings regarding society returning to 'normal'. Future interventions should focus on reframing survivors' beliefs regarding societal expectations and minimise the pressure they experience to keep up with their peers physically and emotionally. Additionally, we recommend creating accessible peer support options for all brain injury survivors as an important step for alleviating loneliness. [ABSTRACT FROM AUTHOR]
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- 2023
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13. Investigating the roles of medial prefrontal and superior temporal cortex in source monitoring.
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Moseley, Peter, Mitrenga, Kaja J., Ellison, Amanda, and Fernyhough, Charles
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ILLUSION (Philosophy) , *TRANSCRANIAL direct current stimulation , *BAYESIAN analysis , *BRAIN imaging , *NEURAL stimulation - Abstract
Abstract Source monitoring, or the ability to recall the origin of information, is a crucial aspect of remembering past experience. One facet of this, reality monitoring, refers to the ability to distinguish between internally generated and externally generated information, biases in which have previously been associated with auditory verbal hallucinations in schizophrenia. Neuroimaging evidence suggests that medial prefrontal and superior temporal (STG) regions may play a role in reality monitoring for auditory verbal information, with evidence from a previous neurostimulation experiment also suggesting that modulation of excitability in STG may affect reality monitoring task performance. Here, two experiments are reported that used transcranial direct current stimulation (tDCS) to modulate excitability in medial prefrontal and superior temporal cortex, to further investigate the role of these brain regions in reality monitoring. In the first experiment (N = 36), tDCS was applied during the encoding stage of the task, while in the second experiment, in a separate sample (N = 36), it was applied during the test stage. There was no effect of tDCS compared to a sham condition in either experiment, with Bayesian analysis providing evidence for the null hypothesis in both cases. This suggests that tDCS applied to superior temporal or medial prefrontal regions may not affect reality monitoring performance, and has implications for theoretical models that link reality monitoring to the therapeutic effect of tDCS on auditory verbal hallucinations. Highlights • Prior research suggests that tDCS applied to the left STG/TPJ affects source monitoring. • We conducted 2 tDCS studies, stimulating during encoding or test of a source memory task. • There was no effect on task performance when tDCS was applied to PFC or STG. [ABSTRACT FROM AUTHOR]
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- 2018
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14. Review: Neurobiology of Attention.
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Ellison, Amanda
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NEUROBIOLOGY - Abstract
Neurobiology of attention edited by Itti, L Rees, G Tsotsos, J; Elsevier Academic Press, Burlington, MA/San Diego, CA/London, 2005, 744 pages, $149.95 (£94.00) ISBN 012 3757312. [Extracted from the article]
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- 2006
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15. Evaluation of new cathepsin K inhibitors (585.4).
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Ellison, Amanda, Wen, Lisa, Huang, Jenq‐Kuen, and McConnell, Rose
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- 2014
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16. The effect of auditory verbal imagery on signal detection in hallucination-prone individuals.
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Moseley, Peter, Smailes, David, Ellison, Amanda, and Fernyhough, Charles
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AUDITORY perception , *MENTAL imagery , *VERBAL ability , *SIGNAL detection (Psychology) , *HALLUCINATIONS , *COMPARATIVE studies , *IMAGINATION , *RESEARCH methodology , *MEDICAL cooperation , *PSYCHOPHYSICS , *RESEARCH , *RESEARCH funding , *SPEECH perception , *EVALUATION research - Abstract
Cognitive models have suggested that auditory hallucinations occur when internal mental events, such as inner speech or auditory verbal imagery (AVI), are misattributed to an external source. This has been supported by numerous studies indicating that individuals who experience hallucinations tend to perform in a biased manner on tasks that require them to distinguish self-generated from non-self-generated perceptions. However, these tasks have typically been of limited relevance to inner speech models of hallucinations, because they have not manipulated the AVI that participants used during the task. Here, a new paradigm was employed to investigate the interaction between imagery and perception, in which a healthy, non-clinical sample of participants were instructed to use AVI whilst completing an auditory signal detection task. It was hypothesized that AVI-usage would cause participants to perform in a biased manner, therefore falsely detecting more voices in bursts of noise. In Experiment 1, when cued to generate AVI, highly hallucination-prone participants showed a lower response bias than when performing a standard signal detection task, being more willing to report the presence of a voice in the noise. Participants not prone to hallucinations performed no differently between the two conditions. In Experiment 2, participants were not specifically instructed to use AVI, but retrospectively reported how often they engaged in AVI during the task. Highly hallucination-prone participants who retrospectively reported using imagery showed a lower response bias than did participants with lower proneness who also reported using AVI. Results are discussed in relation to prominent inner speech models of hallucinations. [ABSTRACT FROM AUTHOR]
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- 2016
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17. Dissociating the neural mechanisms of distance and spatial reference frames.
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Lane, Alison R., Ball, Keira, and Ellison, Amanda
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NEURAL circuitry , *DEPTH perception , *FRAMES of reference (Relativity) , *TRANSCRANIAL magnetic stimulation , *PARIETAL lobe , *OCCIPITAL lobe - Abstract
This study investigated if the neural mechanisms involved in processing distance (near and far) and frame of reference (egocentric and allocentric) can be dissociated. 36 participants completed a conjunction visual search task using either an egocentric (deciding if the target was to their left or right) or an allocentric (deciding if the target was to the left or right of a reference object) frame. Both tasks were performed in near (57 cm) and far (171 cm) space conditions. Participants were separated into three groups, and each received transcranial magnetic stimulation (TMS) to a different site; right posterior parietal cortex (rPPC), right ventral occipital cortex (rVO), or right frontal eye field (rFEF) in addition to sham TMS. The results show that rFEF is critical in the processing of each search at each distance whereas, contrary to previous detection results, TMS over rVO did not affect performance for any condition. TMS over rPPC revealed that specialised egocentric processing in the parietal cortex does not generalise to far space, providing evidence of a separation of the reference frame/distance conflation in the literature. [ABSTRACT FROM AUTHOR]
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- 2015
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18. Mental Health and Wellbeing of Retired Elite and Amateur Rugby Players and Non-contact Athletes and Associations with Sports-Related Concussion: The UK Rugby Health Project.
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Hind, Karen, Konerth, Natalie, Entwistle, Ian, Hume, Patria, Theadom, Alice, Lewis, Gwyn, King, Doug, Goodbourn, Thomas, Bottiglieri, Marianna, Ferraces-Riegas, Paula, Ellison, Amanda, and Chazot, Paul
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SPORTS medicine , *WELL-being , *PSYCHOLOGY of athletes , *AMATEUR athletes , *CROSS-sectional method , *ONE-way analysis of variance , *EFFECT sizes (Statistics) , *SPORTS injuries , *FISHER exact test , *SLEEP , *RUGBY football , *COMPARATIVE studies , *SLEEP disorders , *ALCOHOL drinking , *PSYCHOSOCIAL factors , *BRAIN concussion , *QUESTIONNAIRES , *DESCRIPTIVE statistics , *CHI-squared test , *RESEARCH funding , *RETIREMENT , *DATA analysis software , *ANGER , *ELITE athletes , *MENTAL illness - Abstract
Background: Concerns have intensified over the health and wellbeing of rugby union and league players, and, in particular, about the longer-term effects of concussion. The purpose of this study was to investigate whether there were differences in mental health, sleep and alcohol use between retired elite and amateur rugby code players and non-contact athletes, and to explore associations with sports-related concussion. Methods: 189 retired elite (ER, n = 83) and amateur (AR, n = 106) rugby code players (rugby union n = 145; rugby league n = 44) and 65 former non-contact athletes (NC) were recruited to the UK Rugby Health Project between 2016 and 2018. Details on sports participation and concussion history were obtained by questionnaire, which also included questions on mental health, anger, sleep, mood, alcohol use, social connections and retirement from injury. Data were compared between sports groups (ER, AR and NC), between exposure of three or more or five or more concussions and for years in sport. Results: ER reported more concussions than AR (5.9 ± 6.3 vs. 3.7 ± 6.3, p = 0.022) and NC (0.4 ± 1.0, p < 0.001). ER had a higher overall negative mental health score (indicating poor mental health) than AR (10.4 ± 6.3 vs. 7.4 ± 6.5, d = 0.47, p = 0.003) and NC (7.1 ± 4.8, d = 0.57, p = 0.006) and a lower overall positive score (indicating good mental health) than NC (8.9 ± 4.1 vs. 10.7 ± 3.4, d = 0.46, p = 0.021). Negative scores were highest and positive scores lowest in those reporting three or more concussions (d = 0.36, p = 0.008; d = 0.28, p = 0.040, respectively) or five or more concussions (d = 0.56, p < 0.001; d = 0.325, p = 0.035, respectively). Reported symptoms for sleep disruption were more prevalent in ER than NC, and in former athletes with three or more concussions (d = 0.41–0.605, p < 0.05). There were no significant differences in alcohol score (p = 0.733). Global anger score and covert anger expression was higher in former athletes with five or more concussions (d = 0.32, p = 0.035; d = 0.37, p = 0.016). AR reported greater attachment to friends than NC (d = 0.46, p = 0.033) and 20% of ER reported that they would not turn to anyone if they had a problem or felt upset about anything. Conclusion: There was a significantly higher prevalence of adverse mental health and sleep disruption in ER and in former athletes who reported a higher number of concussions. Anger and irritability were more prevalent in former athletes with a history of five or more concussions. Strategies are needed to address mental health and sleep disturbance in elite rugby code athletes, who are also less likely to seek help should they need it. Further research is needed to elucidate causation, and the neurobiological connection between concussion, sub-concussions and longer-term psychological health and wellbeing. [ABSTRACT FROM AUTHOR]
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- 2022
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19. The role of the superior temporal lobe in auditory false perceptions: A transcranial direct current stimulation study.
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Moseley, Peter, Fernyhough, Charles, and Ellison, Amanda
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TEMPORAL lobe , *AUDITORY perception , *TRANSCRANIAL direct current stimulation , *BRAIN imaging , *BRAIN stimulation , *NEUROPHYSIOLOGY - Abstract
Neuroimaging has shown that a network of cortical areas, which includes the superior temporal gyrus, is active during auditory verbal hallucinations (AVHs). In the present study, healthy, non-hallucinating participants ( N =30) completed an auditory signal detection task, in which participants were required to detect a voice in short bursts of white noise, with the variable of interest being the rate of false auditory verbal perceptions. This paradigm was coupled with transcranial direct current stimulation, a noninvasive brain stimulation technique, to test the involvement of the left posterior superior temporal gyrus in the creation of auditory false perceptions. The results showed that increasing the levels of excitability in this region led to a higher rate of ‘false alarm’ responses than when levels of excitability were decreased, with false alarm responses under a sham stimulation condition lying at a mid-point between anodal and cathodal stimulation conditions. There were also corresponding changes in signal detection parameters. These results are discussed in terms of prominent cognitive neuroscientific theories of AVHs, and potential future directions for research are outlined. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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20. Covert visual search within and beyond the effective oculomotor range.
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Smith, Daniel T., Ball, Keira, and Ellison, Amanda
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EYE movements , *COMPUTER vision , *VISUAL perception , *FEATURE extraction , *ELECTRONIC information resource searching - Abstract
Highlights: [•] We tested oculomotor involvement in covert attention using covert search tasks. [•] Eye-abduction disrupts saccade preparation to targets in the temporal hemispace. [•] Exogenous orienting into the temporal hemispace was impaired during eye-abduction. [•] Endogenous orienting into the temporal hemispace was unaffected by eye-abduction. [•] Optimal exogenous orienting limited to the range of possible saccadic eye-movements. [Copyright &y& Elsevier]
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- 2014
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21. Auditory verbal hallucinations as atypical inner speech monitoring, and the potential of neurostimulation as a treatment option.
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Moseley, Peter, Fernyhough, Charles, and Ellison, Amanda
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AUDITORY hallucinations , *NEURAL circuitry , *NEUROSCIENCES , *NEUROBIOLOGY , *NEUROPHYSIOLOGY ,PHYSIOLOGICAL aspects of speech - Abstract
Highlights: [•] We discuss ‘inner speech’ theories of auditory verbal hallucinations. [•] Atypical self-monitoring may lead to the experience of inner speech as external. [•] We summarize research into the use of neurostimulation to treat hallucinations. [•] Effects of neurostimulation may be due to modulation of self-monitoring networks. [Copyright &y& Elsevier]
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- 2013
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22. Modulation of cortical excitability can speed up blindsight but not improve it.
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Cowey, Alan, Alexander, Iona, and Ellison, Amanda
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VISUAL perception , *VISUAL learning , *PERFORMANCE evaluation , *AWARENESS , *SEMANTICS , *SENSORY perception - Abstract
Blindsight has been widely investigated and its properties documented. One property still debated and contested is the puzzling absence of phenomenal visual percepts of visual stimuli that can be detected with perfect accuracy. We investigated the possibility that phenomenal visual percepts of exogenous visual stimuli in patient GY might be induced by using transcranial direct current stimulation. High contrast and low contrast stimuli were presented as a moving grating in his blind hemifield. When left area MT/V5 was anodally stimulated during the presentation of high-contrast gratings, he never reported a phenomenal percept of a moving grating but showed perfect blindsight performance. When applied along with low contrast gratings, for which accuracy was titrated to 60-70 %, performance did not improve but responses were significantly faster. Cathodal stimulation had no effect. Results are explained in the framework of GY's reorganized cortical connexions and oscillatory patterns known to be involved in awareness in GY. The apparent presence of phenomenal visual percepts in earlier studies is shown to be a semantic confusion about what he means when he says that he sees in his blind field. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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23. Inhibition of Return Impairs Phosphene Detection.
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Smith, Daniel T., Ball, Keira, and Ellison, Amanda
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PHOSPHENES , *VISUAL perception , *TRANSCRANIAL magnetic stimulation , *VISUAL cortex , *ATTENTION , *BRAIN stimulation , *NEUROPHYSIOLOGY - Abstract
Efficient visual exploration requires the ability to select possible target locations via spatial attention and to deselect previously inspected locations via inhibition of return (IOR). Although a great deal is known about the effects of spatial attention on processing in visual cortex, much less is known about the effects of IOR on early visual areas. One possibility is that IOR acts in an opposite way to spatial attention, such that, whereas spatial attention enhances target related neural signals in visual cortex, IOR suppress target-related signals. Using a novel dual-coil TMS protocol, we found that IOR reduced the probability of detecting a TMS-induced phosphene in extrastriate cortex (V5). Specifically, a nonpredictive spatial precue presented 500 or 800 msec before stimulation significantly reduced the probability of detecting a phosphene when the precue appeared contralaterally to the site of stimulation (i.e., ipsilaterally to the potential location of the phosphene), compared with ipsilaterally or centrally presented cues. This result demonstrates that IOR facilitates visual exploration by directly affecting the strength of target-related signals in extrastriate visual cortex. This result is consistent with neurophysiological models of attention, which postulate that IOR modulates perception by biasing competition between sensory representations. [ABSTRACT FROM AUTHOR]
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- 2012
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24. Spatial priming in visual search: memory for body-centred information.
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Ball, Keira, Lane, Alison, Ellison, Amanda, and Schenk, Thomas
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PRIMING (Psychology) , *SPATIAL ability , *VISUAL perception , *SEARCHING behavior , *COGNITIVE psychology , *SPACE perception , *NEUROSCIENCES , *MEMORY - Abstract
Spatial priming allows memory for target locations to be evaluated, whereby when a target appears in the same location across trials, participants become more efficient at locating it and consequently their search times decrease. Previously, we reported priming effects when the location of a target was repeated with respect to the participant's body but not when it was repeated relative to their eye position; therefore, suggesting that body-centred information is available after a delay of at least a few seconds (Ball et al. in Exp Brain Res 204:585-594, ). However, we were unable to rule out the possibility that stable allocentric cues within the room may have contributed to the priming effects that we observed. In this current study, we introduced a condition where despite participants moving to a new location between trials, their position relative to the target was maintained. This movement disrupted any potential room-based cues about the target location. While we replicated our previous finding of priming when the location of the target was repeated relative to the viewer when no movement was required, we also found robust priming effects when participants moved to a new location in between trials. Thus, we provide clear evidence that in our spatial priming task, the location of the target was being coded in a body-centred reference frame and that this information is available after a delay. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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25. TMS over the left angular gyrus impairs the ability to discriminate left from right
- Author
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Hirnstein, Marco, Bayer, Ulrike, Ellison, Amanda, and Hausmann, Markus
- Subjects
- *
TRANSCRANIAL magnetic stimulation , *BRAIN function localization , *LEFT & right (Psychology) , *COGNITIVE ability , *BRAIN imaging , *GENDER differences (Psychology) , *CONTROL (Psychology) , *CEREBRAL hemispheres - Abstract
Abstract: The underlying cognitive and neural mechanisms of the ability to discriminate left from right are hardly explored. Clinical studies from patients with impairments of left–right discrimination (LRD) and neuroimaging data suggest that the left angular gyrus is particularly involved in LRD. Moreover, it is argued that the often reported sex difference in LRD, with women being more susceptible to left–right errors than men, is the result of a stronger lateralization in men than women. Offline repetitive transcranial magnetic stimulation (rTMS) was used to test whether the left angular gyrus is involved in LRD and whether men have a stronger lateralization in LRD than women. Twenty-four participants (12 men, 12 women) completed a behavioral LRD task in three different conditions: after rTMS of the left and right angular gyrus and after ‘sham’ rTMS (control). The results revealed that after rTMS of the left angular gyrus, LRD accuracy rates were significantly reduced compared to the control condition. After rTMS of the right angular gyrus no difference to the control condition was observed. In addition, there was no overall sex difference in the LRD task and men and women were similarly affected by stimulation over the left and right angular gyrus, suggesting that the functional cerebral organization of LRD does not differ in men and women with similar LRD skills. Taken together, the findings suggest that the left angular gyrus is critically involved in LRD. It is argued that the left angular gyrus integrates spatial information with the meaning of the words ‘left’ and ‘right’, thereby assigning the labels ‘left’ and ‘right’ to a certain state or direction, etc. [Copyright &y& Elsevier]
- Published
- 2011
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26. A body-centred frame of reference drives spatial priming in visual search.
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Ball, Keira, Smith, Daniel, Ellison, Amanda, and Schenk, Thomas
- Subjects
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NEUROPSYCHOLOGICAL tests , *PRIMING (Psychology) , *MEDICAL research , *FRAMES (Computer science) , *MEDICAL model - Abstract
Spatial priming in visual search is a well-documented phenomenon. If the target of a visual search is presented at the same location in subsequent trials, the time taken to find the target at this repeated target location is significantly reduced. Previous studies did not determine which spatial reference frame is used to code the location. At least two reference frames can be distinguished: an observer-related frame of reference (egocentric) or a scene-based frame of reference (allocentric). While past studies suggest that an allocentric reference frame is more effective, we found that an egocentric reference frame is at least as effective as an allocentric one (Ball et al. Neuropsychologia 47(6):1585–1591, ). Our previous study did not identify which specific egocentric reference frame was used for the priming: participants could have used a retinotopic or a body-centred frame of reference. Here, we disentangled the retinotopic and body-centred reference frames. In the retinotopic condition, the position of the target stimulus, when repeated, changed with the fixation position, whereas in the body-centred condition, the position of the target stimulus remained the same relative to the display, and thus to the body-midline, but was different relative to the fixation position. We used a conjunction search task to assess the generality of our previous findings. We found that participants relied on body-centred information and not retinotopic cues. Thus, we provide further evidence that egocentric information, and specifically body-centred information, can persist for several seconds, and that these effects are not specific to either a feature or a conjunction search paradigm. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
27. Visual exploration training is no better than attention training for treating hemianopia.
- Author
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Lane, Alison R., Smith, Daniel T., Ellison, Amanda, and Schenk, Thomas
- Subjects
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PEOPLE with visual disabilities , *VISUAL fields , *BLINDNESS , *PHYSICAL training & conditioning , *EYE diseases - Abstract
Patients with homonymous visual field defects experience disabling functional impairments as a consequence of their visual loss. Compensatory visual exploration training aims to improve the searching skills of these patients in order to help them to cope more effectively. However, until now the efficacy of this training has not been compared to that of a control intervention. Given that exploration training uses the visual search paradigm, which is known to require visual attention, in this study the efficacy of the technique was compared with training that requires visual attention but not exploration. Participants completed either exploration training (n= 21), or attention training followed by exploration training (n= 21). Assessment of the visual field, visual search, reading and activities of daily living were performed before and after each intervention that the participants completed. The results revealed that both the exploration training and the attention training led to significant improvements in most of the visual tasks. For most of the tasks exploration training did not prove superior to attention training, and for reading both types of intervention failed to yield any benefits. The results indicate that attention plays a large role in the rehabilitation of homonymous visual field defects. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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- View/download PDF
28. Deficits of reflexive attention induced by abduction of the eye
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Smith, Daniel T., Ball, Keira, Ellison, Amanda, and Schenk, Thomas
- Subjects
- *
REGULATION of eye movements , *ATTENTION , *OCULOMOTOR paralysis , *SENSES , *NEUROPSYCHOLOGY , *COGNITIVE neuroscience - Abstract
Abstract: Attention mediates access of sensory events to higher cognitive systems and can be driven by either top-down voluntary mechanisms or in a bottom-up, reflexive fashion by the sensory properties of a stimulus. The exact mechanisms underlying these different modes of attention are controversial, but both types of attention appear to be tightly coupled to the systems used for the control of eye-movements. Indeed, recent data indicates that patients with opthalmoplegia (paralysis of the eyes) have difficulty voluntarily attending to locations to which saccades cannot be made () and experimentally induced opthalmoplegia disrupts voluntary attention in normal participants. However, the extent to which reflexive attention is mediated by the ability to make eye-movements in normal participants remains unclear. Here, we address this issue by investigating the effect of an experimentally induced opthalmoplegia on voluntary and reflexive attentional orienting during visual search. We observed that abducting the eye into the temporal hemifield elicited deficits of both voluntary and reflexive attention for targets that appeared beyond the oculomotor range. This result confirms the link between oculomotor control and voluntary attention observed in opthalmoplegic patients and demonstrates for the first time that reflexive attention is mediated by the ability to make eye-movements in normal participants. [Copyright &y& Elsevier]
- Published
- 2010
- Full Text
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29. Both egocentric and allocentric cues support spatial priming in visual search
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Ball, Keira, Smith, Daniel, Ellison, Amanda, and Schenk, Thomas
- Subjects
- *
PRIMING (Psychology) , *VISUAL cortex , *VISUAL perception , *ACTION theory (Psychology) , *EGOISM - Abstract
Abstract: The perception–action model proposes that vision for perception and vision for action are subserved by two separate cortical systems, the ventral and dorsal streams, respectively [Milner, A. D., & Goodale, M. A. (1995). The visual brain in action (1st ed.). Oxford: Oxford University Press; Milner, A. D., & Goodale, M. A. (2006). The visual brain in action (2nd ed.). Oxford: Oxford University Press Inc.]. The dorsal stream codes spatial information egocentrically, that is, relative to the observer. Egocentric representations are argued to be highly transient; therefore, it might be expected that egocentric information cannot be used for spatial memory tasks, even when the visual information only needs to be retained for a few seconds. Here, by applying a spatial priming paradigm to a visual search task, we investigated whether short-term spatial memory can use egocentric information. Spatial priming manifests itself in speeded detection times for a target when that target appears in the same location it previously appeared in. Target locations can be defined in either egocentric or allocentric (i.e. relative to other items in the display) frames of reference; however, it is unclear which of these are used in spatial priming, or if both are. Our results show that both allocentric and egocentric cues were used in spatial priming, and that egocentric cues were in fact more effective than allocentric cues for short-term priming. We conclude that egocentric information can persist for several seconds; a conclusion which is at odds with the assumption of the perception–action model that egocentric representations are highly transient. [Copyright &y& Elsevier]
- Published
- 2009
- Full Text
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30. The role of the left dorsolateral prefrontal cortex in attentional bias.
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Knight, Helen C., Smith, Daniel T., and Ellison, Amanda
- Subjects
- *
ATTENTIONAL bias , *PREFRONTAL cortex , *VISUAL fields - Abstract
The DLPFC is thought to be critically involved in maintaining attention away from behaviourally irrelevant information, and in the establishment of attentional control settings. These play an important role in the phenomenon of top-down bias to features in the visual field – also known as attentional bias. This paper probes the involvement of the left DLPFC in attentional bias by manipulating its cortical excitability via tDCS and then analysing these effects following an induced attentional bias towards the colour green. Although both anodal and cathodal tDCS over the left DLPFC decrease distractibility caused by biased but irrelevant objects, further interrogation of our data reveals theoretically differential mechanisms for each type of stimulation. Anodal tDCS appears to increase cognitive control over attentional bias-related items that are behaviourally irrelevant, allowing for their efficient disregard. In contrast, cathodal tDCS appears to lessen the overall effect of the induced attentional bias, potentially by reducing the influence of top-down modulated attentional control settings thus preventing the implementation of the control setting favouring green items. These results suggest a potential causal role of the left DLPFC in the cognitive mechanism underlying attentional bias. • tDCS over left DLPFC decreases distractions caused by biased but irrelevant objects. • Anodal tDCS likely increases cognitive control over irrelevant attentional bias-related items. • Cathodal tDCS likely reduces the influence of top-down attentional control settings. • These results suggest a potential causal role of the left DLPFC in mechanisms underlying attentional bias. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
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31. Light social drinkers are more distracted by irrelevant information from an induced attentional bias than heavy social drinkers.
- Author
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Knight, Helen C., Smith, Daniel T., Knight, David C., and Ellison, Amanda
- Subjects
- *
ATTENTIONAL bias , *ALCOHOL drinking , *DISTRACTION , *PSYCHOLOGY of alcoholism , *PEOPLE with alcoholism - Abstract
It is well established that alcoholics and heavy social drinkers show a bias of attention towards alcohol-related items. Previous research suggests that there is a shared foundation of attentional bias, which is linked to attentional control settings. Specifically, attentional bias relates to a persistent selection of a Feature Search Mode which prioritises attentional bias-related information for selection and processing. However, no research has yet examined the effect of pre-existing biases on the development of an additional attentional bias. This paper seeks to discover how pre-existing biases affect the formation of a new, additional attentional bias. Twenty-five heavy and 25 light social drinkers, with and without a pre-existing bias to alcohol-related items, respectively, had an attentional bias towards the colour green induced via an information sheet. They then completed a series of one-shot change detection tasks. In the critical task, green items were present but task-irrelevant. Irrelevant green items caused significantly more interference for light than heavy social drinkers. This somewhat counter intuitive result is likely due to heavy drinkers having more experience in exerting cognitive control over attentional biases, something not previously observed in investigations of the effects of holding an attentional bias. Our findings demonstrate for the first time that an established attentional bias significantly modulates future behaviour. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
32. Comparing the effect of temporal delay on the availability of egocentric and allocentric information in visual search.
- Author
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Ball, Keira, Birch, Yan, Lane, Alison, Ellison, Amanda, and Schenk, Thomas
- Subjects
- *
EGOISM , *ALLOCENTRISM , *VISUAL perception , *PRIMING (Psychology) , *SPATIAL memory - Abstract
Frames of reference play a central role in perceiving an object’s location and reaching to pick that object up. It is thought that the ventral stream, believed to subserve vision for perception, utilises allocentric coding, while the dorsal stream, argued to be responsible for vision for action, primarily uses an egocentric reference frame. We have previously shown that egocentric representations can survive a delay; however, it is possible that in comparison to allocentric information, egocentric information decays more rapidly. Here we directly compare the effect of delay on the availability of egocentric and allocentric representations. We used spatial priming in visual search and repeated the location of the target relative to either a landmark in the search array (allocentric condition) or the observer’s body (egocentric condition). Three inter-trial intervals created minimum delays between two consecutive trials of 2, 4, or 8 seconds. In both conditions, search times to primed locations were faster than search times to un-primed locations. In the egocentric condition the effects were driven by a reduction in search times when egocentric information was repeated, an effect that was observed at all three delays. In the allocentric condition while search times did not change when the allocentric information was repeated, search times to un-primed target locations became slower. We conclude that egocentric representations are not as transient as previously thought but instead this information is still available, and can influence behaviour, after lengthy periods of delay. We also discuss the possible origins of the differences between allocentric and egocentric priming effects. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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33. Mitigating the impact of air pollution on dementia and brain health: Setting the policy agenda.
- Author
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Castellani, Brian, Bartington, Suzanne, Wistow, Jonathan, Heckels, Neil, Ellison, Amanda, Van Tongeren, Martie, Arnold, Steve R., Barbrook-Johnson, Pete, Bicket, Martha, Pope, Francis D., Russ, Tom C., Clarke, Charlotte L., Pirani, Monica, Schwannauer, Matthias, Vieno, Massimo, Turnbull, Rachel, Gilbert, Nigel, and Reis, Stefan
- Subjects
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AIR pollution , *INDOOR air pollution , *HEALTH policy , *LIFE course approach , *DEMENTIA - Abstract
Emerging research suggests exposure to high levels of air pollution at critical points in the life-course is detrimental to brain health, including cognitive decline and dementia. Social determinants play a significant role, including socio-economic deprivation, environmental factors and heightened health and social inequalities. Policies have been proposed more generally, but their benefits for brain health have yet to be fully explored. Over the course of two years, we worked as a consortium of 20+ academics in a participatory and consensus method to develop the first policy agenda for mitigating air pollution's impact on brain health and dementia, including an umbrella review and engaging 11 stakeholder organisations. We identified three policy domains and 14 priority areas. Research and Funding included: (1) embracing a complexities of place approach that (2) highlights vulnerable populations; (3) details the impact of ambient PM 2.5 on brain health, including current and historical high-resolution exposure models; (4) emphasises the importance of indoor air pollution; (5) catalogues the multiple pathways to disease for brain health and dementia, including those most at risk; (6) embraces a life course perspective; and (7) radically rethinks funding. Education and Awareness included: (8) making this unrecognised public health issue known; (9) developing educational products; (10) attaching air pollution and brain health to existing strategies and campaigns; and (11) providing publicly available monitoring, assessment and screening tools. Policy Evaluation included: (12) conducting complex systems evaluation; (13) engaging in co-production; and (14) evaluating air quality policies for their brain health benefits. Given the pressing issues of brain health, dementia and air pollution, setting a policy agenda is crucial. Policy needs to be matched by scientific evidence and appropriate guidelines, including bespoke strategies to optimise impact and mitigate unintended consequences. The agenda provided here is the first step toward such a plan. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
34. Altering attentional control settings causes persistent biases of visual attention.
- Author
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Knight, Helen C., Smith, Daniel T., Knight, David C., and Ellison, Amanda
- Subjects
- *
ATTENTIONAL bias , *DISTRACTION , *INTEREST (Psychology) , *FLOW theory (Psychology) , *THOUGHT & thinking - Abstract
Attentional control settings have an important role in guiding visual behaviour. Previous work within cognitive psychology has found that the deployment of general attentional control settings can be modulated by training. However, research has not yet established whether long-term modifications of one particular type of attentional control setting can be induced. To address this, we investigated persistent alterations to feature search mode, also known as an attentional bias, towards an arbitrary stimulus in healthy participants. Subjects were biased towards the colour green by an information sheet. Attentional bias was assessed using a change detection task. After an interval of either 1 or 2 weeks, participants were then retested on the same change detection task, tested on a different change detection task where colour was irrelevant, or were biased towards an alternative colour. One experiment included trials in which the distractor stimuli (but never the target stimuli) were green. The key finding was that green stimuli in the second task attracted attention, despite this impairing task performance. Furthermore, inducing a second attentional bias did not override the initial bias toward green objects. The attentional bias also persisted for at least two weeks. It is argued that this persistent attentional bias is mediated by a chronic change to participants’ attentional control settings, which is aided by long-term representations involving contextual cueing. We speculate that similar changes to attentional control settings and continuous cueing may relate to attentional biases observed in psychopathologies. Targeting these biases may be a productive approach to treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
35. Near and far space: Understanding the neural mechanisms of spatial attention.
- Author
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Lane, Alison R., Ball, Keira, Smith, Daniel T., SchENk, Thomas, and Ellison, Amanda
- Abstract
Visuospatial neglect is a multicomponent syndrome, and one dissociation reported is between neglect for near (peripersonal) and far (extrapersonal) space. Owing to patient heterogeneity and extensive lesions, it is difficult to determine the precise neural mechanisms underlying this dissociation using clinical methodology. In this study, transcranial magnetic stimulation was used to examine the involvement of three areas in the undamaged brain, while participants completed a conjunction search task in near and far space. The brain areas investigated were right posterior parietal cortex (rPPC), right frontal eye field (rFEF), and right ventral occipital cortex (rVO), each of which has been implicated in visuospatial processing. The results revealed a double dissociation, whereby rPPC was involved for search in near space only, whilst rVO only became necessary when the task was completed in far space. These data provide clear evidence for a dorsal and ventral dissociation between the processing of near and far space, which is compatible with the functional roles previously attributed to the two streams. For example, the involvement of the dorsal stream in near space reflects its role in vision for action, because it is within this spatial location that actions can be performed. The results also revealed that rFEF is involved in the processing of visual search in both near and far space and may contribute to visuospatial attention and/or the control of eye-movements irrespective of spatial frame. We discuss our results with respect to their clear ramifications for clinical diagnosis and neurorehabilitation. Hum Brain Mapp, 2013. © 2011 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
36. The Involvement of Posterior Parietal Cortex in Feature and Conjunction Visuomotor Search.
- Author
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Lane, Alison R., Smith, Daniel T., Schenk, Thomas, and Ellison, Amanda
- Abstract
Successful interaction with the environment often involves the identification and localization of an item. Right posterior parietal cortex (rPPC) is necessary for the completion of conjunction but not feature visual search, regardless of the attentional requirements. One account for this dissociation is that the rPPC is primarily involved in processing spatial information. For target identification, conjunction tasks require that spatial information is used to determine if features occur at the same location, whereas feature search does not require such a process. This account suggests that if the requirement to localize the target is made explicit, then rPPC may also be necessary for feature search. This was examined using TMS and by manipulating the response mode: Participants were either required to press a button indicating the presence/absence of the target or else had to point to the target. TMS over rPPC did not disrupt performance of the feature task when a button press was required but significantly increased response time and movement time for the same task in the pointing condition. Conjunction search in both response conditions was significantly impaired by TMS. Performance on a task that required pointing to a target in the absence of distractors and thus did not involve visual search was unaffected by rPPC stimulation. We conclude that rPPC is involved in coding and representing spatial information and is therefore crucial when the task requires determining whether two features spatially co-occur or when search is combined with explicit target localization via a visuomotor transformation. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
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