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The role and place of inspiring intuition and creativity in the management of IT projects and development programs of organizations are considered. A conceptual model of the interaction of inspiring intuition and creativity in the processes of IT project management is presented. The influence of inspiring intuition and creativity on the life cycle of innovative projects for the development of knowledge and management technologies is determined. With the help of intuition, IT project managers can anticipate new products, management processes, business areas and development. Such promising actions usually cannot be planned purely rationally, but require an “intuitive feeling.” Vision and imagination open up opportunities for action beyond the paths. This is “inspiring intuition”. This inspiring dimension of intuition has a long-lasting, holistic and gradual effect. The key competencies and strategic priorities of the organization for the implementation of the strategy of sustainable development are considered. In the process of research, two models of sustainable development based on the use of innovative projects and programs were selected. The first model, the Strategic Sustainable Development Framework (FSSD), defines three levels of creative competencies - linear, literal, and holistic. Within the framework of this model, the qualitative influences of individual competencies on the formation of inspiring intuition are determined by example. The second model is related to the application of the system of knowledge and competencies for the management of IT projects and P2M programs. Within this model, priority competencies have been identified that shape the inspiring intuition of project managers. Within the framework of the evaluations, a matrix of qualitative influences on inspiring competence in the processes of implementation of innovative projects and programs was built.

In this study our aim is to investigate the possible effects of Ehrlich ascites tumor (EAT), vitamins C and E on testis immunohistochemically and ultrastructurally. Swiss albino male mice were divided into a control, EAT, EAT + vitamin C, EAT + vitamin E, EAT + vitamin C + vitamin E groups. All treatments were applied for 10 days. After the experiment, testis tissues were taken and PCNA, APAF-1, AT-1 primary antibodies were stained immunohistochemically and also all the tissues were evaluated by electron microscopy. PCNA immunreactivity was seen on spermatocytes-1 and spermatogoniums, APAF-1 immunreactivity was seen on spermatocytes-1 and AT-1 immunreactivity was seen on Leydig cells in all groups. Control and EAT + vitamin E groups had a similar immunreactivity for all antibodies. In ultrastructural evaluations, interconnectional opening was seen on adluminal compartment and also no mature spermatids were seen in testis in all groups except the control group. EAT caused some structural and functional defects on testis probably due to the oxidative stress which was induced by the tumor in the body and also the treatment of vitamin E protected testis better than vitamin C. [ABSTRACT FROM AUTHOR]

Viral acute gastroenteritis is a serious health problem worldwide with the high morbidity and mortality rates. In fact there is no available antiviral treatment for gastroenteritis alternatively, the use of probiotics on which have numerous benefits, has been on the increase recently. Therefore, to be able to identify the strains that can survive in viral acute gastroenteritis and their distinguishable features, seven strains of Lactobacillus spp. were isolated from the stool samples of 0-5 year old children with viral gastroenteritis in this study. Strains were identified by API 50 CH test. EPS production capacities, acid resistance, bile tolerance, antibiotic susceptibilities, and antimicrobial activities against Escherichia coli ATCC 25922 were determined in the order to investigate their probiotic features. Strains were characterized as Lactobacillus plantarum. All strains survived in De Man Rogosa and Sharpe MRS broth with adjusted pH values of 2 and 3, despite high inhibition rates 95.2-99.2% and 98.3-99.2%, respectively . Furthermore, all strains maintained their viability within MRS broth mediums that contain 0.15%, 0.2% and 0.3% bile viability rates as 81.4-92.5%, 80.9- 87.3% and 73.2-89.2%, respectively . Exopolysaccharide production 4.13-50.33 mg/mL was observed in all strains except for 182a. No antimicrobial activity was detected against E. coli ATCC 25922. All strains experienced high sensitivity to erythromycin while showing resistance to vancomycin. In conclusion, L. plantarum strains obtained in this study can be further investigated for describe other probiotic features and may be used for the production of new probiotic products to provide sufficient therapies in further studies.

Studies the expression of growth factors in fetal human olfactory mucosa during development. Constant turnover of primary sensory neurons in the periphery which results to the remodeling of neuronal circuits and synapses; Immunoreactivity to epidermal growth factor-alpha and nerve growth factor-beta in the epithelium; Nerve growth factor-beta detection; Mechanisms and factors that control the turnover of primary sensory neurons.

In recent years, studies made concerning the treatment of obesity, it has been observed that weight loss is accelerated by human chorionic gonadotropin (hCG) hormone preparation used for hypothalamic dysfunction in obesity treatment. Our aim was to observe immunohistochemical and ultrastructural changes in rat, were fed ad libitum with cafeteria diet to gain weight, related to the local hCG injection in adrenal glands. In our study, 10 female obese, 10 male obese, 10 non-obese female and 10 non-obese male rats were used. In each group, single dose of subcutaneous beta hCG injection has been applied to 7 rats for 5 weeks in 5 days of the week, and placebo has been applied to the remaining 3 rats. Following the injection, the tissues were evaluated immunohistochemically. As a result of our studies, there weren't any clear differences in adrenal glands and it was thought that the increases and decreases in the number of hormone receptors may be seen in parallel with the increases and decreases in hormone levels. As conclusion, we observed thet the implementation of beta hCG in addition to diet has no effect on adrenal glands. [ABSTRACT FROM AUTHOR]

In recent years, studies made concerning the treatment of obesity, it has been observed that weight loss is accelerated by human chorionic gonadotropin (hCG) hormone preparation used for hypothalamic dysfunction in obesity treatment single dose of subcutaneously to abdominal region. Our aim was to observe immunohistochemical changes in male rats, were fed ad libitum with cafeteria diet to gain weight, related to the local hCG injection in testis. In our study, 10 male obese and 10 non-obese male rats were used. In each group, single dose of subcutaneous beta-hCG injection has been applied to 7 rats for 5 weeks in 5 days of the week, and placebo has been applied to the remaining 3 rats. Following the injection, the tissues were evaluated immunohistochemically. As a result of our studies, there weren't any clear differences in testis and it was thought that the increases and decreases in the number of hormone receptors may be seen in parallel with the increases and decreases in hormone levels. As a conclusion, we believe that the implementation of beta-hCG in addition to diet has no effect on testis. [ABSTRACT FROM AUTHOR]

Radiation-induced renal fibrosis (RIRF) is a progressive, irreversible condition causing chronic kidney disease. Pentoxifylline (PTX) and vitamin E may mitigate radiation-induced damage and fibrosis. This study assesses their effectiveness. We used four groups, each with six rats: radiation therapy alone (RT-only), radiation therapy plus drug treatment (RT + drug), drug treatment alone (drug-only), and a control group. Rats were monitored for three months, with weight measurements every four weeks. Afterward, rats were analyzed biochemically and histologically, with blood and tissue samples taken for statistical comparison. No significant differences in serum creatinine levels and body weight were observed. RT-only group had more severe kidney tubule effects. Histomorphological, immunohistochemical, and TUNEL analyses showed significant RIRF mitigation in the RT + drug group. Our study highlighted molecular pathways (SMAD, TGF-beta, VEGF) and histological markers (collagens, a-SMA, fibronectin, metalloproteinases) associated with RIRF. PTX and vitamin E reduced ionizing radiation's impact on renal cells and mitigated radiation-induced kidney fibrosis. Further human studies are needed to confirm these findings., (© 2024. The Author(s).)

The aim of study was to comprehensively investigate the effect of nutritional habits and supplement use on health-related quality of life during social isolation period. This study was a cross-sectional study. A total of 418 participants (73.4% were women and 26.6% were men) participated in this study. Participants' demographic information, nutritional habits, and quality of life were questioned, and anthropometric measurements were obtained. A significant difference was found in the main meal skipping status of individuals by age group. The consumption of milk, yoghurt, ayran, legumes, cereal products other than bread, vegetables, fruits, oilseeds, and snack foods was similar in both periods. Furthermore, frequencies of multivitamins, multiminerals, vitamin B 12 , vitamin C, vitamin D, iron, calcium, omega-3, and probiotics were similar during and before the pandemic. A significant difference was found in scores obtained on the Quality of Life Scale (QOLS) by age group. There was a significant difference in the quality of life scores by body mass index (BMI) groups. It was concluded that quality of life decreased due to the increase in body weight during pandemic period. The social isolation period did not make a clear difference in the nutritional habits of individuals and the use of nutritional supplements. When the main meal skipping situations were evaluated within the scope of nutritional habits, those who did not skip their main meal received the highest score on the QOLS.

The objective of this investigation was to examine alterations in PTEN expression within ovarian tissue in a rat model of polycystic ovary syndrome (PCOS). The analysis also encompassed the examination of PTEN alterations in the ovarian tissue throughout the process of folliculogenesis in rats with normal ovulatory cycles. The study involved 12 adult female Sprague‒Dawley rats randomly assigned to the letrozole-induced polycystic ovary syndrome (PCOS) group as part of an animal-based research endeavour. The sections derived from the ovaries were subjected to immunohistochemical staining for PTEN. The evaluation of PTEN staining levels in ovarian tissues was conducted using electron microscopy. Follicle counts, as well as hormonal and biochemical analyses (serum luteinising hormone (LH), follicle-stimulating hormone (FSH), anti-Müllerian hormone (AMH), testosterone, oestradiol levels and serum glucose, triglyceride, HDL and LDL-cholesterol levels), were conducted to provide evidence of the manifestation of polycystic ovary syndrome (PCOS) in rats. The number of primordial and Graafian follicles in the PCOS group decreased significantly, and the number of primary, secondary and antral follicles increased significantly. PTEN expression was found to be significantly higher in the PCOS group than in the control group in the primordial follicle oocyte cytoplasm, primordial follicle granulosa cells, primary follicle oocyte cytoplasm, primary follicle granulosa cells, antral follicle oocyte cytoplasm, antral follicle granulosa cells, and corpus luteum (p = 0.007, p = 0.001, p = 0.001, p = 0.001, p = 0.001, p = 0.002, and p = 0.018, respectively). In the non-PCOS group, a time-dependent comparison of the amount of oocyte cytoplasm and PTEN staining in granulosa cells of the oocytes at different stages of development was performed. While the follicles were developing from the primordial follicle to the primary and antral follicle, the amount of PTEN staining in the oocyte cytoplasm decreased, whereas the PTEN activity in the granulosa cells increased as the oocyte developed (p = 0.001 and p = 0.001, respectively). The current investigation demonstrated changes in PTEN expression in ovarian tissue throughout the course of normal folliculogenesis, as well as in instances of disrupted folliculogenesis, with a focus on rats with PCOS., (© 2023. The Author(s).)

Background and Objectives: Recently, the terms autophagy and apoptosis have been studied on implants, especially in cell culture and in vitro studies, but in vivo evaluations are limited. The aim of this study was to compare the differences in apoptosis and autophagy intensity at the molecular and cellular level in periodontal and peri-implant diseases., Methods: Sixty-four biopsy samples were obtained from 52 patients, 36 female and 16 male, whose mean age was between 18 and 75, and were included in the study. The periodontitis group was defined as PG (n:30 sample) and the peri-implantitis group as IG (n:34 samples). Granulation tissues as biopsy materials were collected, and immunohistochemical analysis was performed with hematoxylin-eosin, Masson's trichrome, anti-MAP1LC3A, anti-beclin, and anti-active caspase-3 antibodies and terminal TdT-mediated dUTP-biotin nick end labeling (TUNEL) methods. The histological slide images were evaluated with the ImageJ software program. Inflammatory cell density in epithelial tissue, inflammatory cell density in connective tissue, the density of necrotic tissue debris, and collagen density in connective tissue were scored between 0 and 3 (0: none, 1: minimal, 2: moderate, 3: severe by hematoxylin-eosin and Masson's trichrome). The antibody binding reaction areas were evaluated per unit area (mm 2 ) in connective tissue by immunohistochemical examination., Results: As histochemical evaluations, there was no statistically significant differences the mean inflammatory cell density value in the epithelial tissue, inflammatory cell density value in the connective tissue, density value of necrotic tissue debris, collagen density value in the connective tissue between the groups. There was no statistically significant difference on immunohistochemical staining with LC3, caspase-3, Beclin-1 and TUNEL between the two groups (p > .05)., Conclusions: A higher rate of inflammatory accumulation was shown on peri-implantitis, but no difference was found between periodontitis and peri-implantitis according to autophagy and apoptosis markers. Studies with high sample sizes with different markers are needed., (© 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Capsaicin is a bioactive compound found in the fruits (i.e., peppers) of the plant genus Capsicum , which is widely used in many cultures. Besides many health effects of this compound, it can also be effective in body weight control through various mechanisms such as regulating lipolysis in adipocytes, increasing the feeling of satiety, stimulating energy expenditure, and reducing energy intake. This study investigated capsaicin and its effects on body weight control. In clinical studies, the amount of capsaicin affecting body weight loss differ. Longitudinal and randomized controlled studies are needed to explain the effects of capsaicin on body weight control.Key teaching points• Capsaicin can decrease hunger through hormones in the gastrointestinal tract.• Capsaicin can increase energy expenditure through brown adipose tissue.• Capsaicin can increase lipolysis in white adipose tissue.• More comprehensive studies are needed to clarify this issue.

Abstract: This study was carried out to investigate whether repeated controlled ovarian hyperstimulation (COH) affects ovarian reserve. For this reason, we aimed to show possible changes in the expression of PTEN and FOXO3, which are involved in preserving the over-reserve, after applying the COH protocol methods. For this purpose, 18 young Wistar albino female rats (8 weeks old) were randomly assigned as group 1 (control), group 2, and group 3 as 6 subjects in each group. Experimental groups were treated with 10 IU/0.1 mL pregnant mare's serum gonadotropin and a COH protocol consisting of 10 IU/0.1 mL human chorionic gonadotropin injection after 48 h. This procedure was applied three and five times to group 2 and group 3, respectively. For the control groups, the same procedures were performed with 0.1 mL of 0.9% sodium chloride solution. At the end of the experiment, the ovarium tissues were placed in a 10% neutral formaldehyde solution for light microscopic examinations. In histological sections stained with hematoxylin and eosin, the number of ovarian follicles was determined using the physical dissector method. However, the expression of PTEN, FOXO3, and LH-R molecules was evaluated by immunohistochemical methods. As a result of our study, it was concluded that COH administration reduces the expression levels of PTEN and FOXO3 proteins and LH-R, which are among the essential components of the PIK3 intracellular signaling pathway and also increased the levels of hormones such as follicle-stimulating hormone, estradiol, and luteinizing hormone, which are over-reserve markers, and causes adverse effects on the histological structure, oocyte morphology, and number of ovaries., Lay Summary: Today, approximately 10-15% of couples experience fertility problems. However, assisted reproductive techniques help people with fertility problems to get pregnant. The main purpose of these techniques is to put the sperm and egg together outside the woman's body where the eggs are fertilized and then to return the fertilized eggs (embryos) to the womb. During a woman's menstrual cycle, several hormones influence the growth of the eggs. This process can be mimicked by using various medications. Medication is given to increase the number of eggs that develop. However, this method is not the same as normal ovulation. Therefore, in our study, we wanted to examine the effect that developing multiple follicles has on the number and quality of eggs remaining for the future.

Purpose: There is still no widely-accepted local agent proven to be effective in nerve regeneration. We aimed to investigate the effects of chitosan gel and platelet-rich plasma MATERIALS AND METHODS: Electrophysiological measurements were performed before and immediately after injury. The injured nerves were covered with spongostan impregnated with the following agents: Group 1 (Control Group): Saline at a dose of 50 µl; Group 2: Chitosan (CHT) at a dose of 50 µl; Group 3: PRP at a dose of 50 ml; and Group 4: a solution of CHT with PRP (1:1). The final measurements were performed after 3 weeks and the injured nerve of each rat was removed., Results: There were statistically-significant differences between the groups regarding the measurements of the after-treatment values of stimulus threshold (p < 0.05). The best improvement in electrophysiological measurement and histopathological evaluation was found in Group 4 (CHT-PRP)., Conclusion: Chitosan gel has a positive effect on nerve healing and applying it along with PRP can enhance the effect of chitosan., (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Objectives: In this study, it is aimed to investigate the potential protective effect of caffeic acid phenethyl ester (CAPE) on ototoxicity caused by gentamicin in a rat model., Materials and Methods: Thirty Wistar albino rats were divided into 3 groups. Group I was selected as the control group. Gentamicin was administered intraperitoneally in group II, gentamicin and CAPE in group III. Audiological assessment was performed by the distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) measurements before and after treatment of each group. At the end of the study all rats were decapitated, cochlea was removed and electron microscopic examination was performed., Results: In group II post-treatment DPOAE levels were found to be lower than pretreatment DPOAE levels ( P <0.05). However, in group III, there is no significant difference between pre- and post-treatment DPOAE levels ( P >0.05). Except for Group I, ABR thresholds increased after the procedure and this increase was statistically significant ( P <0.0001). According to histological examination by transmission electron microscopy, CAPE has a cellular protective effect against gentamicin ototoxicity., Conclusion: CAPE may ameliorate hearing deterioration caused by gentamicin ototoxicity and protect the cochlear cells from apoptosis due to the strong antioxidant effect., Competing Interests: The authors declare that no conflict of interest exists.

Abstract: The most feared complication of the hyaluronic acid injections in the periorbital region is embolism of the central retinal artery. The present study aimed to compare the effectiveness of hyaluronidase administered intravenously (systemically) alone or in combination with streptokinase with that of intra-arterial revascularization. Thirty rats were divided into 5 groups. The bilateral oblique groin flap of the rats was raised; the right side was the experiment group, and the left side was the sham control. The right superficial epigastric artery was occluded with a hyaluronic acid injection. After occlusion, no additional procedures were performed in group 1, whereas group 2 received systemic hyaluronidase, group 3 received intra-arterial hyaluronidase, group 4 received systemic hyaluronidase and streptokinase, and group 5 received intra-arterial hyaluronidase and streptokinase. On the seventh day, the rats were killed, flap necrosis rate was calculated, and histological examination was performed. There was no significant difference in the necrosis rates of the rats in groups 2, 3, 4, and 5 (P > 0.05). In histological evaluation, the histological view closest to normal arterial structure was observed in group 4. Immunohistochemical analysis revealed that the ischemia scores of systemic therapy were significantly lower than those of intra-arterial therapy. These results have shown that hyaluronidase and streptokinase administered systemically is as effective as intra-arterial revascularization and does not cause arterial wall degeneration. It has been shown that systemic administration of hyaluronidase and streptokinase is as successful as intra-arterial revascularization in the treatment of arterial embolism with hyaluronic acid., Competing Interests: Conflicts of interest and sources of funding: This study is funded by Gazi University, Division of Scientific Research Projects (No. 01/2016-20). The authors declare no conflict of interest., (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)