Search

Your search keyword '"Elner, Susan G."' showing total 278 results
Start Over Author "Elner, Susan G."
278 results on '"Elner, Susan G."'

5. Fluorescein Angiography versus Optical Coherence Tomography for Diagnosis of Uveitic Macular Edema

Author

Kempen, John H, Sugar, Elizabeth A, Jaffe, Glenn J, Acharya, Nisha R, Dunn, James P, Elner, Susan G, Lightman, Susan L, Thorne, Jennifer E, Vitale, Albert T, Altaweel, Michael M, and Group, Multicenter Uveitis Steroid Treatment Trial Research

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Clinical Research, Eye Disease and Disorders of Vision, Biomedical Imaging, Prevention, Eye, Capillary Permeability, Cross-Sectional Studies, Drug Implants, Female, Fluocinolone Acetonide, Fluorescein Angiography, Glucocorticoids, Humans, Macular Edema, Male, Middle Aged, Panuveitis, Retina, Retinal Vessels, Sensitivity and Specificity, Tomography, Optical Coherence, Uveitis, Intermediate, Uveitis, Posterior, Multicenter Uveitis Steroid Treatment (MUST) Trial Research Group, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry, Ophthalmology and optometry
Abstract

ObjectiveTo evaluate agreement between fluorescein angiography (FA) and optical coherence tomography (OCT) results for diagnosis of macular edema in patients with uveitis.DesignMulticenter cross-sectional study.ParticipantsFour hundred seventy-nine eyes with uveitis from 255 patients.MethodsThe macular status of dilated eyes with intermediate uveitis, posterior uveitis, or panuveitis was assessed via Stratus-3 OCT and FA. To evaluate agreement between the diagnostic approaches, κ statistics were used.Main outcome measuresMacular thickening (MT; center point thickness, ≥ 240 μm per reading center grading of OCT images) and macular leakage (ML; central subfield fluorescein leakage, ≥ 0.44 disc areas per reading center grading of FA images), and agreement between these outcomes in diagnosing macular edema.ResultsOptical coherence tomography (90.4%) more frequently returned usable information regarding macular edema than FA (77%) or biomicroscopy (76%). Agreement in diagnosis of MT and ML (κ = 0.44) was moderate. Macular leakage was present in 40% of cases free of MT, whereas MT was present in 34% of cases without ML. Biomicroscopic evaluation for macular edema failed to detect 40% and 45% of cases of MT and ML, respectively, and diagnosed 17% and 17% of cases with macular edema that did not have MT or ML, respectively; these results may underestimate biomicroscopic errors (ophthalmologists were not explicitly masked to OCT and FA results). Among eyes free of ML, phakic eyes without cataract rarely (4%) had MT. No factors were found that effectively ruled out ML when MT was absent.ConclusionsOptical coherence tomography and FA offered only moderate agreement regarding macular edema status in uveitis cases, probably because what they measure (MT and ML) are related but nonidentical macular pathologic characteristics. Given its lower cost, greater safety, and greater likelihood of obtaining usable information, OCT may be the best initial test for evaluation of suspected macular edema. However, given that ML cannot be ruled out if MT is absent and vice versa, obtaining the second test after negative results on the first seems justified when detection of ML or MT would alter management. Given that biomicroscopic evaluation for macular edema erred frequently, ancillary testing for macular edema seems indicated when knowledge of ML or MT status would affect management.Financial disclosure(s)Proprietary or commercial disclosure may be found after the references.

Published
2013

6. Novel TMEM98, MFRP, PRSS56 variants in a large United States high hyperopia and nanophthalmos cohort

Author

Prasov, Lev, Guan, Bin, Ullah, Ehsan, Archer, Steven M., Ayres, Bernadete M., Besirli, Cagri G., Wiinikka-Buesser, Laurel, Comer, Grant M., Del Monte, Monte A., Elner, Susan G., Garnai, Sarah J., Huryn, Laryssa A., Johnson, Kayla, Kamat, Shivani S., Lieu, Philip, Mian, Shahzad I., Rygiel, Christine A., Serpen, Jasmine Y., Pawar, Hemant S., Brooks, Brian P., Moroi, Sayoko E., Richards, Julia E., and Hufnagel, Robert B.

Published
2020
Full Text
View/download PDF

7. Dissociations of the Fluocinolone Acetonide Implant: The Multicenter Uveitis Steroid Treatment (MUST) Trial and Follow-up Study

Author

Jaffe, Glenn J., Branchaud, Brenda, Hahn, Paul, Koreen, Larry, Lad, Eleonora (Nora) M., Lin, Phoebe, Martel, Joseph Nissim, (Shah) Serrano, Neha, Skalak, Cindy, Vajzovic, Lejla, Baer, Claxton, Bryant, Joyce, Chavala, Sai, Cusick, Michael, Day, Shelley, Dayani, Pouya, Ehlers, Justis, Kesen, Muge, Lee, Annie, Melamud, Alex, Qureshi, Jawad A., Scott, Adrienne Williams, See, Robert F., Shuler, Robert K., Wood, Megan, Yeh, Steven, Fernandes, Alcides, Gibbs, Deborah, Leef, Donna, Martin, Daniel F., Srivastava, Sunil, Dunn, James P., Begum, Hosne, Boring, Jeff, Brotherson, Kristen L., Burkholder, Bryn, Butler, Nicholas J., Cain, Dennis, Cook, Mary A., Emmert, David, Graul, Janis R., Herring, Mark, Laing, Ashley, Leung, Theresa G., Mahon, Michael C., Moradi, Ahmafreza, Nwankwo, Antonia, Ostheimer, Trucian L., Reed, Terry, Arnold, Ellen, Barnabie, Patricia M., Belair, Marie-Lynn, Bolton, Stephen G., Brodine, Joseph B., Brown, Diane M., Brune, Lisa M., Galor, Anat, Gan, Theresa, Jacobowitz, Adam, Kapoor, Meera, Kedhar, Sanjay, Kim, Stephen, Leder, Henry A., Livingston, Alison G., Morton, Yavette, Nolan, Kisten, Peters, George B., Soto, Priscilla, Stevenson, Ricardo, Tarver-Carr, Michelle, Wang, Yue, Foster, C. Stephen, Anesi, Stephen D., Linda Bruner, Ceron, Olga, Hinkle, David M., Persons, Nancy, Wentworth, Bailey, Acevedo, Sarah, Anzaar, Fahd, Cesca, Tom, Contero, Angelica, Fitzpatrick, Kayleigh, Goronga, Faith, Johnson, Jyothir, Lebron, Karina Q., Marvell, Danielle, Morgan, Chandra, Patel, Nita, Pinto, Jennifer, Siddique, Sana S., Sprague, Janet, Yilmaz, Taygan, Sen, H. Nida, Bono, Michael, Cunningham, Denise, Hayes, Darryl, Koutsandreas, Dessie, Nussenblatt, Robert B., Sherry, Patti R., Short, Gregory L., Smith, Wendy, Temple, Alana, Bamji, Allison, Coleman, Hanna, Davuluri, Geetaniali, Faia, Lisa, Gottlieb, Chloe, Jirawuthiworavong, Guy V., Lew, Julie C., Mercer, Richard, Obiyor, Dominic, Perry, Cheryl H., Potapova, Natalia, Weichel, Eric, Wroblewski, Keith J., Latkany, Paul A., Coonan, Corinne, Honda, Andrea, Lorenzo-Latkany, Monica, Masini, Robert, Morell, Susan, Nguyen, Angela, Badamo, Jason, Boyd, Kenneth M., Enos, Matthew, Gallardo, Jenny, Jarczynski, Jacek, Lee, Ji Yun, McGrosky, Mirjana, Nour, Ann, Sanchez, Meredith, Steinberg, Kate, Stawell, Richard J., Breayley, Lisa, D'Sylva, Carly, Glatz, Elizabeth, Hodgson, Lauren, Lim, Lyndell, Ling, Cecilia, McIntosh, Rachel, Morrison (Ewing), Julie, Newton, Andrew, Sanmugasundram, Sutha, Smallwood, Richard, Zamir, Ehud, Hunt, Nicola, Jones, Lisa, Koukouras, Ignatios, Williams, Suzanne, Merrill, Pauline T., Carns, Danielle, Richine, Len, Voskuil-Marre, Denise L., Woo, Kisung, Gaynes, Bruce, Giannoulis, Christina, Hulvey, Pam, Kernbauer, Elaine, Khan, Heena S., Levine, Sarah J., Toennessen, Scott, Tonner, Eileen, Wang, Robert C., Aguado, Hank, Arceneaux, Sally, Duignan, Karen, Fish, Gary E., Hesse, Nick, Jaramillo, Diana, Mackens, Michael, Arnwine, Jean, Callanan, David, Cummings, Kimberly, Gray, Keith, Howden, Susie, Mutz, Karin, Sanchez, Brenda, Lightman, Susan, Ismetova, Filis, Prytherch, Ashley, Seguin-Greenstein, Sophie, Tomkins, Oren, Bar, Asat, Edwards, Kate, Joshi, Lavanish, Moraji, Jiten, Samy, Ahmed, Stubbs, Timothy, Taylor, Simon, Towler, Hamish, Tronnberg, Rebecca, Holland, Gary N., Almanzor, Robert D., Castellanos, Jose, Hubschman, Jean Pierre, Johiro, Ann K., Kukuyev, Alla, Levinson, Ralph D., McCannel, Colin A., Ransome, Susan S., Gonzales, Christine R., Gupta, Anurag, Kalyani, Partho S., Kapamajian, Michael A., Kappel, Peter J., Arcinue, Cheryl, Chuang, Janne, Barteselli, Giulio, Currie, Glenn, Mendoza, Veronica, Powell, Debbie, Clark, Tom, Cochran, Denine E., Freeman, William R., Hedaya, Joshua, Kemper, Tiara, Kozak, Igor, LeMoine, Jacqueline M., Loughran, Megan E., Magana, Luzandra, Mojana, Francesca, Morrison, Victoria, Nguyen, Vivian, Oster, Stephen F., Acharya, Nisha, Clay, David, Lee, Salena, Lew, Mary, Margolis, Todd P., Stewart, Jay, Wong, Ira G., Brown, Debra, Khouri, Claire M., Goldstein, Debra A., Birnbaum, Andrea, Degillio, Andrea, Rosa, Gemma De la, Ramirez, Carmen, Simjanowski, Evica, Skelly, Mariner, Castro-Malek, Anna L., Crooke, Catherine E., Huntley, Melody, Nash, Katrina, Niec, Marcia, Pyatetsky, Dimitry, Ramirez, Misel, Rozenbajgier, Zuzanna, Tessler, Howard H., Davis, Janet L., Albini, Thomas A., Chin, Marie, Castaño, Daniela, Elizondo, Ariana, Ho, Macy, Kovach, Jaclyn L., Lin, Richard C-S., Mandelcorn, Efrem, Nguyen, Jackie K-D., Pacini, Aura, Pineda, Susan, Pinto, David A., Rebimbas, Jose, Stepien, Kimberly E., Teran, Claudia, Elner, Susan G., Bernard, Hillary, Fournier, Linda, Godsey, Lindsay, Goings, Linda, Hackel, Richard, Hesselgrave, Moella, Jayasundera, K. Thiran, Prusak, Robert, Titus, Pamela, Bergeron, Melissa, Blosser, Reneé, Brown, Rebecca, Chrisman-McClure, Carrie, Gothrup, Julie R., Saxe, Stephen J., Sizemore, Deanna, Kempen, John H., Berger, James, Drossner, Sheri, DuPont, Joan C., Maguire, Albert M., Petner, Janice, Engelhard, Stephanie, Hopkins, Tim, McCall, Dawn, McRay, Monique, Will, Daniel, Xu, Wei, Lo, Jonathan, Salvo, Rebecca, Windsor, Elizabeth, Weeney, Laurel, Pavan, Peter R., Albritton, Ken, Leto, JoAnn, Madow, Brian, Mayor, Lori, Pautler, Scott E., Saxon, Wyatt, Soto, Judy, Goldstein, Burton, Klukoff, Amy, Lambright, Lucy, McDonald, Kim, Ortiz, Maria, Scymanky, Susan, Szalay, Dee Dee, Rao, Narsing, Davis, Tamara, Douglass, Jackie, Linton, Judith, Padilla, Margaret, Ramos, Sylvia, Aguirre, Alexia, Chong, Lawrence, Cisneros, Lupe, Corona, Elizabeth, Eliott, Dean, Fawzi, Amani, Garcia, Jesse, Khurana, Rahul, Lim, Jennifer, Mead, Rachel, Tsai, Julie H., Vitale, Albert, Bernstein, Paul S., Carlstrom, Bonnie, Gilman, James, Hanseen, Sandra, Morris, Paula, Ramirez, Diana, Wegner, Kimberley, Sheppard, John D., Anthony, Brianne, Casper, Amber, Felix-Kent, Lisa, Fernandez, Jeanette, Johnson, Tari, Scoper, Stephen V., Cole, R. Denise, Crawford, Nancy, Franklin, Lisa, Hamelin, Krista, Martin, Jen, Marx, Rebecca, Schultz, Gregory, Webb, Joseph, Yeager, Pamela, Kim, Rosa Y., Benz, Matthew S., Brown, David M., Chen, Eric, Fish, Richard H., Kegley, Eric, Shawver, Laura, Wong, Tien P., De La Garza, Rebecca, Friday (Hay), Shayla, Rao, P. Kumar, Adcock, Eve, Apte, Rajendra S., Baladenski, Amy, Curtis, Rhonda, Gould, Sarah, Hebden, Amanda, Kambarian, Jamie, Meyer, Charla, Pistorius, Sam, Quinn, Melanie, Rathert, Greg, Blinder, Kevin J., Hartz, Ashley, Light, Pam, Shah, Gaurav K., VanGelder, Russell, Jabs, Douglas A., Altaweel, Michael M., Kurinij, Natalie, Brown, Diane, Prusakowski, Nancy, Thorne, Jennifer E., Hubbard, Larry, Wittes, Janet, Barlow, William E., Hochberg, Marc, Lyon, Alice T., Palestine, Alan G., Simon, Lee S., Rosenbaum, James T., Smith, Harmon, Davis, Janet, Thorne, Jennifer, Acharya, Nisha R., Vitale, Albert T., Boring, Jeffrey A., Alexander, Judith, Ng, Wai Ping, Friedman, David S., Adler, Anna, Burke, Alyce, Katz, Joanne, Reed, Susan, Ansari, Husam, Cohen, Nicholas, Modak, Sanjukta, Sugar, Elizabeth A., Burke, Alyce E., Drye, Lea T., Van Natta, Mark L., Frick, Kevin, Louis, Thomas A., Shade, David, Pascual, Karen, Slutsky-Sanon, Jill S., Glomp, Colby, Nieves, Melissa A., Stevens, Maria, Allen, Amanda, Hilal, Yasmin, Holbrook, Janet T., Abreu, Francis, Casper, Anne Shanklin, Ewing, Cathleen, Hart, Adante, Lears, Andrea, Li, Shirley, Meinert, Jill, Morrison, Vinnette, Nowakowski, Deborah, Reyes, Girlie, Shade, Dave M., Smith, Jacqueline, Steuernagle, Karen, Van Natta, Mark, Venugopal, Vidya, Yu, Tsung, Chen, Paul, Collins, Karen, Dodge, John, Frick, Kevin D., Jackson, Rosetta, Jimenez, Christian, Landers, Ariel, Livingston, Hope, Meinert, Curtis L., Rayapudi, Sobharani, Shen, Weijiang, Shiflett, Charles, Smith, Rochelle, Tieman, Ada, Tonascia, James A., Zheng, Richard, Allan, James, Benz, Wendy K., Domalpally, Amitha, Johnson, Kristine A., Myers, Dawn J., Pak, Jeong Won, Reimers, James L., Christianson, Debra J., Chambers, Geoffrey, Fleischli, Margaret A., Freund, Jacquelyn, Glander, Kathleen E., Goulding, Anne, Gama, Vonnie, Gangaputra, Sapna, Hafford, Dennis, Harris, Susan E., Hubbard, Larry D., Joyce, Jeffrey M., Kruse, Christina N., Nagle, Lauren, Remm, Amy, Padden-Lechten, Gwyn E., Pohlman, Alyson, Shaw, Ruth A., Sivesind, Peggy, Thayer, Dennis, Treichel, Erika, Warren, Kelly J., Watson, Sheila M., Webster, Mary K., White, James K., Wilhelmson, Tara, and Zhang, Grace

Published
2016
Full Text
View/download PDF

10. Factors Predicting Visual Acuity Outcome in Intermediate, Posterior, and Panuveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial

Author

Jaffe, Glenn J., Branchaud, Brenda, Hahn, Paul, Koreen, Larry, Lad, Eleonora (Nora) M., Lin, Phoebe, Martel, Joseph Nissim, Serrano, Neha (Shah), Skalak, Cindy, Vajzovic, Lejla, Baer, Claxton, Bryant, Joyce, Chavala, Sai, Cusick, Michael, Day, Shelley, Dayani, Pouya, Ehlers, Justis, Kesen, Muge, Lee, Annie, Melamud, Alex, Qureshi, Jawad A., Scott, Adrienne Williams, See, Robert F., Shuler, Robert K., Wood, Megan, Yeh, Steven, Fernandes, Alcides, Gibbs, Deborah, Leef, Donna, Martin, Daniel F., Srivastava, Sunil, Dunn, James P., Begum, Hosne, Boring, Jeff, Brotherson, Kristen L., Burkholder, Bryn, Butler, Nicholas J., Cain, Dennis, Cook, Mary A., Emmert, David, Graul, Janis R., Herring, Mark, Laing, Ashley, Leung, Theresa G., Mahon, Michael C., Moradi, Ahmafreza, Nwankwo, Antonia, Ostheimer, Trucian L., Reed, Terry, Arnold, Ellen, Barnabie, Patricia M., Belair, Marie-Lynn, Bolton, Stephen G., Brodine, Joseph B., Brown, Diane M., Brune, Lisa M., Galor, Anat, Gan, Theresa, Jacobowitz, Adam, Kapoor, Meera, Kedhar, Sanjay, Kim, Stephen, Leder, Henry A., Livingston, Alison G., Morton, Yavette, Nolan, Kisten, Peters, George B., Soto, Priscilla, Stevenson, Ricardo, Tarver-Carr, Michelle, Wang, Yue, Foster, C. Stephen, Anesi, Stephen D., Bruner, Linda, Ceron, Olga, Hinkle, David M., Persons, Nancy, Wentworth, Bailey, Acevedo, Sarah, Anzaar, Fahd, Cesca, Tom, Contero, Angelica, Fitzpatrick, Kayleigh, Goronga, Faith, Johnson, Jyothir, Lebron, Karina Q., Marvell, Danielle, Morgan, Chandra, Patel, Nita, Pinto, Jennifer, Siddique, Sana S., Sprague, Janet, Yilmaz, Taygan, Sen, H. Nida, Bono, Michael, Cunningham, Denise, Hayes, Darryl, Koutsandreas, Dessie, Nussenblatt, Robert B., Sherry, Patti R., Short, Gregory L., Smith, Wendy, Temple, Alana, Bamji, Allison, Coleman, Hanna, Davuluri, Geetaniali, Faia, Lisa, Gottlieb, Chloe, Jirawuthiworavong, Guy V., Lew, Julie C., Mercer, Richard, Obiyor, Dominic, Perry, Cheryl H., Potapova, Natalia, Weichel, Eric, Wroblewski, Keith J., Latkany, Paul A., Coonan, Corinne, Honda, Andrea, Lorenzo-Latkany, Monica, Masini, Robert, Morell, Susan, Nguyen, Angela, Badamo, Jason, Boyd, Kenneth M., Enos, Matthew, Gallardo, Jenny, Jarczynski, Jacek, Lee, Ji Yun, McGrosky, Mirjana, Nour, Ann, Sanchez, Meredith, Steinberg, Kate, Stawell, Richard J., Breayley, Lisa, D'Sylva, Carly, Glatz, Elizabeth, Hodgson, Lauren, Lim, Lyndell, Ling, Cecilia, McIntosh, Rachel, Morrison (Ewing), Julie, Newton, Andrew, Sanmugasundram, Sutha, Smallwood, Richard, Zamir, Ehud, Hunt, Nicola, Jones, Lisa, Koukouras, Ignatios, Williams, Suzanne, Merrill, Pauline T., Carns, Danielle, Richine, Len, Voskuil-Marre, Denise L., Woo, Kisung, Gaynes, Bruce, Giannoulis, Christina, Hulvey, Pam, Kernbauer, Elaine, Khan, Heena S., Levine, Sarah J., Toennessen, Scott, Tonner, Eileen, Wang, Robert C., Aguado, Hank, Arceneaux, Sally, Duignan, Karen, Fish, Gary E., Hesse, Nick, Jaramillo, Diana, Mackens, Michael, Arnwine, Jean, Callanan, David, Cummings, Kimberly, Gray, Keith, Howden, Susie, Mutz, Karin, Sanchez, Brenda, Lightman, Susan, Ismetova, Filis, Prytherch, Ashley, Seguin-Greenstein, Sophie, Tomkins, Oren, Bar, Asat, Edwards, Kate, Joshi, Lavanish, Moraji, Jiten, Samy, Ahmed, Stubbs, Timothy, Taylor, Simon, Towler, Hamish, Tronnberg, Rebecca, Holland, Gary N., Almanzor, Robert D., Castellanos, Jose, Hubschman, Jean Pierre, Johiro, Ann K., Kukuyev, Alla, Levinson, Ralph D., McCannel, Colin A., Ransome, Susan S., Gonzales, Christine R., Gupta, Anurag, Kalyani, Partho S., Kapamajian, Michael A., Kappel, Peter J., Arcinue, Cheryl, Chuang, Janne, Barteselli, Giulio, Currie, Glenn, Mendoza, Veronica, Powell, Debbie, Clark, Tom, Cochran, Denine E., Freeman, William R., Hedaya, Joshua, Kemper, Tiara, Kozak, Igor, LeMoine, Jacqueline M., Loughran, Megan E., Magana, Luzandra, Mojana, Francesca, Morrison, Victoria, Nguyen, Vivian, Oster, Stephen F., Acharya, Nisha, Clay, David, Lee, Salena, Lew, Mary, Margolis, Todd P., Stewart, Jay, Wong, Ira G., Brown, Debra, Khouri, Claire M., Goldstein, Debra A., Birnbaum, Andrea, Degillio, Andrea, Rosa, Gemma De la, Ramirez, Carmen, Simjanowski, Evica, Skelly, Mariner, Castro-Malek, Anna L., Crooke, Catherine E., Huntley, Melody, Nash, Katrina, Niec, Marcia, Pyatetsky, Dimitry, Ramirez, Misel, Rozenbajgier, Zuzanna, Tessler, Howard H., Davis, Janet L., Albini, Thomas A., Chin, Marie, Castaño, Daniela, Elizondo, Ariana, Ho, Macy, Kovach, Jaclyn L., Lin, Richard C-S., Mandelcorn, Efrem, Nguyen, Jackie K-D., Pacini, Aura, Pineda, Susan, Pinto, David A., Rebimbas, Jose, Stepien, Kimberly E., Teran, Claudia, Elner, Susan G., Bernard, Hillary, Fournier, Linda, Godsey, Lindsay, Goings, Linda, Hackel, Richard, Hesselgrave, Moella, Jayasundera, K. Thiran, Prusak, Robert, Titus, Pamela, Bergeron, Melissa, Blosser, Reneé, Brown, Rebecca, Chrisman-McClure, Carrie, Gothrup, Julie R., Saxe, Stephen J., Sizemore, Deanna, Kempen, John H., Berger, James, Drossner, Sheri, DuPont, Joan C., Maguire, Albert M., Petner, Janice, Engelhard, Stephanie, Hopkins, Tim, Lo, Jonathan, McCall, Dawn, McRay, Monique, Salvo, Rebecca, Will, Daniel, Xu, Wei, Windsor, Elizabeth, Weeney, Laurel, Pavan, Peter R., Albritton, Ken, Leto, JoAnn, Madow, Brian, Mayor, Lori, Pautler, Scott E., Saxon, Wyatt, Soto, Judy, Goldstein, Burton, Klukoff, Amy, Lambright, Lucy, McDonald, Kim, Ortiz, Maria, Scymanky, Susan, Szalay, Dee Dee, Rao, Narsing, Davis, Tamara, Douglass, Jackie, Linton, Judith, Padilla, Margaret, Ramos, Sylvia, Rao, Narsing A., Aguirre, Alexia, Chong, Lawrence, Cisneros, Lupe, Corona, Elizabeth, Eliott, Dean, Fawzi, Amani, Garcia, Jesse, Khurana, Rahul, Lim, Jennifer, Mead, Rachel, Tsai, Julie H., Vitale, Albert, Bernstein, Paul S., Carlstrom, Bonnie, Gilman, James, Hanseen, Sandra, Morris, Paula, Ramirez, Diana, Wegner, Kimberley, Sheppard, John D., Anthony, Brianne, Casper, Amber, Felix-Kent, Lisa, Fernandez, Jeanette, Johnson, Tari, Scoper, Stephen V., Cole, R. Denise, Crawford, Nancy, Franklin, Lisa, Hamelin, Krista, Martin, Jen, Marx, Rebecca, Schultz, Gregory, Webb, Joseph, Yeager, Pamela, Kim, Rosa Y., Benz, Matthew S., Brown, David M., Chen, Eric, Fish, Richard H., Kegley, Eric, Shawver, Laura, Wong, Tien P., De La Garza, Rebecca, Friday (Hay), Shayla, Rao, P. Kumar, Adcock, Eve, Apte, Rajendra S., Baladenski, Amy, Curtis, Rhonda, Gould, Sarah, Hebden, Amanda, Kambarian, Jamie, Meyer, Charla, Pistorius, Sam, Quinn, Melanie, Rathert, Greg, Blinder, Kevin J., Hartz, Ashley, Light, Pam, Shah, Gaurav K., VanGelder, Russell, Jabs, Douglas A., Altaweel, Michael M., Holbrook, Janet T., Kurinij, Natalie, Brown, Diane, Prusakowski, Nancy, Thorne, Jennifer E., Hubbard, Larry, Wittes, Janet, Barlow, William E., Hochberg, Marc, Lyon, Alice T., Palestine, Alan G., Simon, Lee S., Rosenbaum, James T., Smith, Harmon, Davis, Janet, Thorne, Jennifer, Acharya, Nisha R., Vitale, Albert T., Boring, Jeffrey A., Alexander, Judith, Ng, Wai Ping, Friedman, David S., Adler, Anna, Burke, Alyce, Katz, Joanne, Reed, Susan, Ansari, Husam, Cohen, Nicholas, Modak, Sanjukta, Sugar, Elizabeth A., Burke, Alyce E., Drye, Lea T., Van Natta, Mark L., Frick, Kevin, Katz, JoAnn, Louis, Thomas A., Shade, David, Pascual, Karen, Slutsky-Sanon, Jill S., Allen, Amanda, Glomp, Colby, Hilal, Yasmin, Nieves, Melissa A., Stevens, Maria, Abreu, Francis, Casper, Anne Shanklin, Ewing, Cathleen, Hart, Adante, Lears, Andrea, Li, Shirley, Meinert, Jill, Morrison, Vinnette, Nowakowski, Deborah, Reyes, Girlie, Shade, Dave M., Smith, Jacqueline, Steuernagle, Karen, Van Natta, Mark, Venugopal, Vidya, Yu, Tsung, Chen, Paul, Collins, Karen, Dodge, John, Frick, Kevin D., Jackson, Rosetta, Jimenez, Christian, Landers, Ariel, Livingston, Hope, Meinert, Curtis L., Rayapudi, Sobharani, Shen, Weijiang, Shiflett, Charles, Smith, Rochelle, Tieman, Ada, Tonascia, James A., Zheng, Richard, Allan, James, Benz, Wendy K., Domalpally, Amitha, Johnson, Kristine A., Myers, Dawn J., Won Pak, Jeong, Reimers, James L., Chambers, Geoffrey, Christianson, Debra J., Fleischli, Margaret A., Freund, Jacquelyn, Gama, Vonnie, Gangaputra, Sapna, Glander, Kathleen E., Goulding, Anne, Hafford, Dennis, Harris, Susan E., Hubbard, Larry D., Joyce, Jeffrey M., Kruse, Christina N., Nagle, Lauren, Padden-Lechten, Gwyn E., Pohlman, Alyson, Remm, Amy, Shaw, Ruth A., Sivesind, Peggy, Thayer, Dennis, Treichel, Erika, Warren, Kelly J., Watson, Sheila M., Webster, Mary K., White, James K., Wilhelmson, Tara, Zhang, Grace, and Lightman, Susan L.

Published
2015
Full Text
View/download PDF

12. Reply

Author

Conrady, Christopher D., primary, Hu, Katherine, additional, Shakoor, Akbar, additional, Larochelle, Marissa, additional, Sassalos, Therese, additional, Elner, Susan G., additional, Jayasundera, Thiran, additional, and Vitale, Albert T., additional

Published
2022
Full Text
View/download PDF

19. Ocular Toxoplasmosis after Exposure to Wild Game

Author

Conrady, Christopher D., primary, Besirli, Cagri G., additional, Baumal, Caroline R., additional, Kovach, Jaclyn L., additional, Etzel, Justin D., additional, Tsui, Jonathan C., additional, Elner, Susan G., additional, and Johnson, Mark W., additional

Published
2021
Full Text
View/download PDF

21. Toll-like receptor 4 (TLR4) of retinal pigment epithelial cells participates in transmembrane signaling in response to photoreceptor outer segments

Author

Kindzelskii, Andrei L., Elner, Victor M., Elner, Susan G., Yang, Dongli, Hughes, Bret A., and Petty, Howard R.

Subjects
Metabolism -- Analysis, Retinal pigment epithelium -- Analysis, Retinal pigment epithelium -- Chemical properties, Receptor antibodies -- Analysis, Biological sciences, Health
Abstract

Retinal pigment epithelial (RPE) cells mediate the recognition and clearance of effete photoreceptor outer segments (POS), a process central to the maintenance of normal vision. Given the emerging importance of Toll-like receptors (TLRs) in transmembrane signaling in response to invading pathogens as well as endogenous substances, we hypothesized that TLRs are associated with RPE cell management of POS. TLR4 clusters on human RPE cells in response to human, but not bovine, POS. However, TLR4 clustering could be inhibited by saturating concentrations of an inhibitory anti-TLR4 mAb. Furthermore, human POS binding to human RPE cells elicited transmembrane metabolic and calcium signals within RPE cells, which could be blocked by saturating doses of an inhibitory anti-TLR4 mAb. However, the heterologous combination of bovine POS and human RPE did not trigger these signals. The pattern recognition receptor CD36 collected at the POS-RPE cell interface for both homologous and heterologous samples, but human TLR4 only collected at the human POS--human RPE cell interface. Kinetic experiments of human POS binding to human RPE cells revealed that CD36 arrives at the POS-RPE interface followed by TLR4 accumulation within 2 rain. Metabolic and calcium signals immediately follow. Similarly, the production of reactive oxygen metabolites (ROMs) was observed for the homologous human system, but not the heterologous bovine POS-human RPE cell system. As (a) the bovine POS/human RPE combination did not elicit TLR4 accumulation, RPE signaling, or ROM release, (h) TLR4 arrives at the POS-RPE cell interface just before signaling, (c) TLR4 blockade with an inhibitory anti-TLR4 mAb inhibited TLR4 clustering, signaling, and ROM release in the human POS--human RPE system, and (d) TLR4 demonstrates similar clustering mad signaling responses to POS in confluent RPE monolayers, we suggest that TLR4 of RPE cells participates in transmembrane signaling events that contribute to the management of human POS. KEY WORDS: RPE activation * metabolism * photoreceptor outer segments * Toll-like receptors * reactive oxygen metabolites

Published
2004

22. Ocular Toxoplasmosis after Exposure to Wild Game.

Author

Conrady, Christopher D., Besirli, Cagri G., Baumal, Caroline R., Kovach, Jaclyn L., Etzel, Justin D., Tsui, Jonathan C., Elner, Susan G., and Johnson, Mark W.

Abstract

To describe eight patients with toxoplasma retinochoroiditis following exposure to wild game. Retrospective, multicenter case series Eight men, aged 29 to 71 (mean, 56 years), developed toxoplasmic retinochoroiditis after hunting and/or consuming wild game in the United States, including seven deer and one bear. Five patients developed the disease after eating undercooked game meat, while three developed ocular findings after cleaning hunted animals. Seven patients were healthy prior to exposure. LogMAR visual acuity at presentation was 0.697 ± 0.745, improving to 0.256 ± 0.335 by last follow-up. Disease complications developed in five (62.5%) patients, of which recurrence of retinochoroiditis was the most common. Contact with wild game is a potential source of primary ocular toxoplasmosis in immunocompetent adults. Hunters and consumers of rare game are at risk of serious ocular disease and appropriate contact precautions and cooking may reduce this complication. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

42. Factors Predicting Visual Acuity Outcome in Intermediate, Posterior, and Panuveitis: The Multicenter Uveitis Steroid Treatment (MUST) Trial

Author

Kempen, John H., primary, Van Natta, Mark L., additional, Altaweel, Michael M., additional, Dunn, James P., additional, Jabs, Douglas A., additional, Lightman, Susan L., additional, Thorne, Jennifer E., additional, Holbrook, Janet T., additional, Jaffe, Glenn J., additional, Branchaud, Brenda, additional, Hahn, Paul, additional, Koreen, Larry, additional, Lad, Eleonora (Nora) M., additional, Lin, Phoebe, additional, Martel, Joseph Nissim, additional, Serrano, Neha (Shah), additional, Skalak, Cindy, additional, Vajzovic, Lejla, additional, Baer, Claxton, additional, Bryant, Joyce, additional, Chavala, Sai, additional, Cusick, Michael, additional, Day, Shelley, additional, Dayani, Pouya, additional, Ehlers, Justis, additional, Kesen, Muge, additional, Lee, Annie, additional, Melamud, Alex, additional, Qureshi, Jawad A., additional, Scott, Adrienne Williams, additional, See, Robert F., additional, Shuler, Robert K., additional, Wood, Megan, additional, Yeh, Steven, additional, Fernandes, Alcides, additional, Gibbs, Deborah, additional, Leef, Donna, additional, Martin, Daniel F., additional, Srivastava, Sunil, additional, Begum, Hosne, additional, Boring, Jeff, additional, Brotherson, Kristen L., additional, Burkholder, Bryn, additional, Butler, Nicholas J., additional, Cain, Dennis, additional, Cook, Mary A., additional, Emmert, David, additional, Graul, Janis R., additional, Herring, Mark, additional, Laing, Ashley, additional, Leung, Theresa G., additional, Mahon, Michael C., additional, Moradi, Ahmafreza, additional, Nwankwo, Antonia, additional, Ostheimer, Trucian L., additional, Reed, Terry, additional, Arnold, Ellen, additional, Barnabie, Patricia M., additional, Belair, Marie-Lynn, additional, Bolton, Stephen G., additional, Brodine, Joseph B., additional, Brown, Diane M., additional, Brune, Lisa M., additional, Galor, Anat, additional, Gan, Theresa, additional, Jacobowitz, Adam, additional, Kapoor, Meera, additional, Kedhar, Sanjay, additional, Kim, Stephen, additional, Leder, Henry A., additional, Livingston, Alison G., additional, Morton, Yavette, additional, Nolan, Kisten, additional, Peters, George B., additional, Soto, Priscilla, additional, Stevenson, Ricardo, additional, Tarver-Carr, Michelle, additional, Wang, Yue, additional, Foster, C. Stephen, additional, Anesi, Stephen D., additional, Bruner, Linda, additional, Ceron, Olga, additional, Hinkle, David M., additional, Persons, Nancy, additional, Wentworth, Bailey, additional, Acevedo, Sarah, additional, Anzaar, Fahd, additional, Cesca, Tom, additional, Contero, Angelica, additional, Fitzpatrick, Kayleigh, additional, Goronga, Faith, additional, Johnson, Jyothir, additional, Lebron, Karina Q., additional, Marvell, Danielle, additional, Morgan, Chandra, additional, Patel, Nita, additional, Pinto, Jennifer, additional, Siddique, Sana S., additional, Sprague, Janet, additional, Yilmaz, Taygan, additional, Sen, H. Nida, additional, Bono, Michael, additional, Cunningham, Denise, additional, Hayes, Darryl, additional, Koutsandreas, Dessie, additional, Nussenblatt, Robert B., additional, Sherry, Patti R., additional, Short, Gregory L., additional, Smith, Wendy, additional, Temple, Alana, additional, Bamji, Allison, additional, Coleman, Hanna, additional, Davuluri, Geetaniali, additional, Faia, Lisa, additional, Gottlieb, Chloe, additional, Jirawuthiworavong, Guy V., additional, Lew, Julie C., additional, Mercer, Richard, additional, Obiyor, Dominic, additional, Perry, Cheryl H., additional, Potapova, Natalia, additional, Weichel, Eric, additional, Wroblewski, Keith J., additional, Latkany, Paul A., additional, Coonan, Corinne, additional, Honda, Andrea, additional, Lorenzo-Latkany, Monica, additional, Masini, Robert, additional, Morell, Susan, additional, Nguyen, Angela, additional, Badamo, Jason, additional, Boyd, Kenneth M., additional, Enos, Matthew, additional, Gallardo, Jenny, additional, Jarczynski, Jacek, additional, Lee, Ji Yun, additional, McGrosky, Mirjana, additional, Nour, Ann, additional, Sanchez, Meredith, additional, Steinberg, Kate, additional, Stawell, Richard J., additional, Breayley, Lisa, additional, D'Sylva, Carly, additional, Glatz, Elizabeth, additional, Hodgson, Lauren, additional, Lim, Lyndell, additional, Ling, Cecilia, additional, McIntosh, Rachel, additional, Morrison (Ewing), Julie, additional, Newton, Andrew, additional, Sanmugasundram, Sutha, additional, Smallwood, Richard, additional, Zamir, Ehud, additional, Hunt, Nicola, additional, Jones, Lisa, additional, Koukouras, Ignatios, additional, Williams, Suzanne, additional, Merrill, Pauline T., additional, Carns, Danielle, additional, Richine, Len, additional, Voskuil-Marre, Denise L., additional, Woo, Kisung, additional, Gaynes, Bruce, additional, Giannoulis, Christina, additional, Hulvey, Pam, additional, Kernbauer, Elaine, additional, Khan, Heena S., additional, Levine, Sarah J., additional, Toennessen, Scott, additional, Tonner, Eileen, additional, Wang, Robert C., additional, Aguado, Hank, additional, Arceneaux, Sally, additional, Duignan, Karen, additional, Fish, Gary E., additional, Hesse, Nick, additional, Jaramillo, Diana, additional, Mackens, Michael, additional, Arnwine, Jean, additional, Callanan, David, additional, Cummings, Kimberly, additional, Gray, Keith, additional, Howden, Susie, additional, Mutz, Karin, additional, Sanchez, Brenda, additional, Lightman, Susan, additional, Ismetova, Filis, additional, Prytherch, Ashley, additional, Seguin-Greenstein, Sophie, additional, Tomkins, Oren, additional, Bar, Asat, additional, Edwards, Kate, additional, Joshi, Lavanish, additional, Moraji, Jiten, additional, Samy, Ahmed, additional, Stubbs, Timothy, additional, Taylor, Simon, additional, Towler, Hamish, additional, Tronnberg, Rebecca, additional, Holland, Gary N., additional, Almanzor, Robert D., additional, Castellanos, Jose, additional, Hubschman, Jean Pierre, additional, Johiro, Ann K., additional, Kukuyev, Alla, additional, Levinson, Ralph D., additional, McCannel, Colin A., additional, Ransome, Susan S., additional, Gonzales, Christine R., additional, Gupta, Anurag, additional, Kalyani, Partho S., additional, Kapamajian, Michael A., additional, Kappel, Peter J., additional, Arcinue, Cheryl, additional, Chuang, Janne, additional, Barteselli, Giulio, additional, Currie, Glenn, additional, Mendoza, Veronica, additional, Powell, Debbie, additional, Clark, Tom, additional, Cochran, Denine E., additional, Freeman, William R., additional, Hedaya, Joshua, additional, Kemper, Tiara, additional, Kozak, Igor, additional, LeMoine, Jacqueline M., additional, Loughran, Megan E., additional, Magana, Luzandra, additional, Mojana, Francesca, additional, Morrison, Victoria, additional, Nguyen, Vivian, additional, Oster, Stephen F., additional, Acharya, Nisha, additional, Clay, David, additional, Lee, Salena, additional, Lew, Mary, additional, Margolis, Todd P., additional, Stewart, Jay, additional, Wong, Ira G., additional, Brown, Debra, additional, Khouri, Claire M., additional, Goldstein, Debra A., additional, Birnbaum, Andrea, additional, Degillio, Andrea, additional, Rosa, Gemma De la, additional, Ramirez, Carmen, additional, Simjanowski, Evica, additional, Skelly, Mariner, additional, Castro-Malek, Anna L., additional, Crooke, Catherine E., additional, Huntley, Melody, additional, Nash, Katrina, additional, Niec, Marcia, additional, Pyatetsky, Dimitry, additional, Ramirez, Misel, additional, Rozenbajgier, Zuzanna, additional, Tessler, Howard H., additional, Davis, Janet L., additional, Albini, Thomas A., additional, Chin, Marie, additional, Castaño, Daniela, additional, Elizondo, Ariana, additional, Ho, Macy, additional, Kovach, Jaclyn L., additional, Lin, Richard C-S., additional, Mandelcorn, Efrem, additional, Nguyen, Jackie K-D., additional, Pacini, Aura, additional, Pineda, Susan, additional, Pinto, David A., additional, Rebimbas, Jose, additional, Stepien, Kimberly E., additional, Teran, Claudia, additional, Elner, Susan G., additional, Bernard, Hillary, additional, Fournier, Linda, additional, Godsey, Lindsay, additional, Goings, Linda, additional, Hackel, Richard, additional, Hesselgrave, Moella, additional, Jayasundera, K. Thiran, additional, Prusak, Robert, additional, Titus, Pamela, additional, Bergeron, Melissa, additional, Blosser, Reneé, additional, Brown, Rebecca, additional, Chrisman-McClure, Carrie, additional, Gothrup, Julie R., additional, Saxe, Stephen J., additional, Sizemore, Deanna, additional, Kempen, John H., additional, Berger, James, additional, Drossner, Sheri, additional, DuPont, Joan C., additional, Maguire, Albert M., additional, Petner, Janice, additional, Engelhard, Stephanie, additional, Hopkins, Tim, additional, Lo, Jonathan, additional, McCall, Dawn, additional, McRay, Monique, additional, Salvo, Rebecca, additional, Will, Daniel, additional, Xu, Wei, additional, Windsor, Elizabeth, additional, Weeney, Laurel, additional, Pavan, Peter R., additional, Albritton, Ken, additional, Leto, JoAnn, additional, Madow, Brian, additional, Mayor, Lori, additional, Pautler, Scott E., additional, Saxon, Wyatt, additional, Soto, Judy, additional, Goldstein, Burton, additional, Klukoff, Amy, additional, Lambright, Lucy, additional, McDonald, Kim, additional, Ortiz, Maria, additional, Scymanky, Susan, additional, Szalay, Dee Dee, additional, Rao, Narsing, additional, Davis, Tamara, additional, Douglass, Jackie, additional, Linton, Judith, additional, Padilla, Margaret, additional, Ramos, Sylvia, additional, Rao, Narsing A., additional, Aguirre, Alexia, additional, Chong, Lawrence, additional, Cisneros, Lupe, additional, Corona, Elizabeth, additional, Eliott, Dean, additional, Fawzi, Amani, additional, Garcia, Jesse, additional, Khurana, Rahul, additional, Lim, Jennifer, additional, Mead, Rachel, additional, Tsai, Julie H., additional, Vitale, Albert, additional, Bernstein, Paul S., additional, Carlstrom, Bonnie, additional, Gilman, James, additional, Hanseen, Sandra, additional, Morris, Paula, additional, Ramirez, Diana, additional, Wegner, Kimberley, additional, Sheppard, John D., additional, Anthony, Brianne, additional, Casper, Amber, additional, Felix-Kent, Lisa, additional, Fernandez, Jeanette, additional, Johnson, Tari, additional, Scoper, Stephen V., additional, Cole, R. Denise, additional, Crawford, Nancy, additional, Franklin, Lisa, additional, Hamelin, Krista, additional, Martin, Jen, additional, Marx, Rebecca, additional, Schultz, Gregory, additional, Webb, Joseph, additional, Yeager, Pamela, additional, Kim, Rosa Y., additional, Benz, Matthew S., additional, Brown, David M., additional, Chen, Eric, additional, Fish, Richard H., additional, Kegley, Eric, additional, Shawver, Laura, additional, Wong, Tien P., additional, De La Garza, Rebecca, additional, Friday (Hay), Shayla, additional, Rao, P. Kumar, additional, Adcock, Eve, additional, Apte, Rajendra S., additional, Baladenski, Amy, additional, Curtis, Rhonda, additional, Gould, Sarah, additional, Hebden, Amanda, additional, Kambarian, Jamie, additional, Meyer, Charla, additional, Pistorius, Sam, additional, Quinn, Melanie, additional, Rathert, Greg, additional, Blinder, Kevin J., additional, Hartz, Ashley, additional, Light, Pam, additional, Shah, Gaurav K., additional, VanGelder, Russell, additional, Kurinij, Natalie, additional, Brown, Diane, additional, Prusakowski, Nancy, additional, Hubbard, Larry, additional, Wittes, Janet, additional, Barlow, William E., additional, Hochberg, Marc, additional, Lyon, Alice T., additional, Palestine, Alan G., additional, Simon, Lee S., additional, Rosenbaum, James T., additional, Smith, Harmon, additional, Davis, Janet, additional, Thorne, Jennifer, additional, Acharya, Nisha R., additional, Vitale, Albert T., additional, Boring, Jeffrey A., additional, Alexander, Judith, additional, Ng, Wai Ping, additional, Friedman, David S., additional, Adler, Anna, additional, Burke, Alyce, additional, Katz, Joanne, additional, Reed, Susan, additional, Ansari, Husam, additional, Cohen, Nicholas, additional, Modak, Sanjukta, additional, Sugar, Elizabeth A., additional, Burke, Alyce E., additional, Drye, Lea T., additional, Frick, Kevin, additional, Katz, JoAnn, additional, Louis, Thomas A., additional, Shade, David, additional, Pascual, Karen, additional, Slutsky-Sanon, Jill S., additional, Allen, Amanda, additional, Glomp, Colby, additional, Hilal, Yasmin, additional, Nieves, Melissa A., additional, Stevens, Maria, additional, Abreu, Francis, additional, Casper, Anne Shanklin, additional, Ewing, Cathleen, additional, Hart, Adante, additional, Lears, Andrea, additional, Li, Shirley, additional, Meinert, Jill, additional, Morrison, Vinnette, additional, Nowakowski, Deborah, additional, Reyes, Girlie, additional, Shade, Dave M., additional, Smith, Jacqueline, additional, Steuernagle, Karen, additional, Van Natta, Mark, additional, Venugopal, Vidya, additional, Yu, Tsung, additional, Chen, Paul, additional, Collins, Karen, additional, Dodge, John, additional, Frick, Kevin D., additional, Jackson, Rosetta, additional, Jimenez, Christian, additional, Landers, Ariel, additional, Livingston, Hope, additional, Meinert, Curtis L., additional, Rayapudi, Sobharani, additional, Shen, Weijiang, additional, Shiflett, Charles, additional, Smith, Rochelle, additional, Tieman, Ada, additional, Tonascia, James A., additional, Zheng, Richard, additional, Allan, James, additional, Benz, Wendy K., additional, Domalpally, Amitha, additional, Johnson, Kristine A., additional, Myers, Dawn J., additional, Won Pak, Jeong, additional, Reimers, James L., additional, Chambers, Geoffrey, additional, Christianson, Debra J., additional, Fleischli, Margaret A., additional, Freund, Jacquelyn, additional, Gama, Vonnie, additional, Gangaputra, Sapna, additional, Glander, Kathleen E., additional, Goulding, Anne, additional, Hafford, Dennis, additional, Harris, Susan E., additional, Hubbard, Larry D., additional, Joyce, Jeffrey M., additional, Kruse, Christina N., additional, Nagle, Lauren, additional, Padden-Lechten, Gwyn E., additional, Pohlman, Alyson, additional, Remm, Amy, additional, Shaw, Ruth A., additional, Sivesind, Peggy, additional, Thayer, Dennis, additional, Treichel, Erika, additional, Warren, Kelly J., additional, Watson, Sheila M., additional, Webster, Mary K., additional, White, James K., additional, Wilhelmson, Tara, additional, and Zhang, Grace, additional

Published
2015
Full Text
View/download PDF

43. Detection of Retinal Metabolic Stress due to Central Serous Retinopathy

Author

Field, Matthew G., Elner, Victor M., Park, Seung, Hackel, Richard, Heckenlively, John R., Elner, Susan G., and Petty, Howard R.

Subjects
Adult, Male, Oxidative Stress, Central Serous Chorioretinopathy, Flavoproteins, Humans, Reproducibility of Results, Fluorescein Angiography, Article, Biomarkers, Fluorescence, Retina
Abstract

To test whether eyes with central serous retinopathy have elevated retinal flavoprotein fluorescence (FPF) using a novel clinical imaging method.Three male patients with unilateral central serous retinopathy were examined for FPF at 535 nm induced by 1-msec flashes of 467 nm light. FPF was captured with an electron multiplying charged-coupled device camera with a 512 x 512 pixel chip. Average intensity of retinal FPF for each affected eye was compared with the contralateral, unaffected eye and with six age-matched control eyes by analyzing histograms of pixel intensities plotted for each eye.For each patient, the central serous retinopathy-affected eye had a significantly greater retinal FPF when compared with the retinal FPF of the unaffected eye. Eyes affected with central serous retinopathy had retinal FPF values that averaged 98% greater than the retinal FPF of age-matched control eyes.Flavoprotein fluorescence analysis may be useful for rapidly and noninvasively identifying metabolic tissue stress of central serous retinopathy.

Published
2009

44. Retinal Flavoprotein Autofluorescence as a Measure of Retinal Health

Author

Elner, Susan G., Elner, Victor M., Field, Matthew G., Park, Seung, Heckenlively, John R., and Petty, Howard R.

Subjects
Adult, Apoptosis, Articles, Hydrogen Peroxide, Retinal Pigment Epithelium, Middle Aged, Ceramides, Antioxidants, Fluorescence, Retina, Acetylcysteine, Mitochondria, Retinal Diseases, Sphingosine, Flavin-Adenine Dinucleotide, Photography, Humans, Cells, Cultured, Aged
Abstract

To establish that increased autofluorescence of mitochondrial flavoproteins, an indicator of mitochondrial oxidative stress, correlates with retinal cell dysfunction.Retinal flavoprotein autofluorescence (FA) was imaged in humans with a fundus camera modified with 467DF8-nm excitation and 535-nm emission filters and a back-illuminated, electron-multiplying, charge-coupled device camera interfaced with a computer equipped with customized image capture software. Multiple digital images, centered on the fovea, were obtained from each eye. Histograms of pixel intensities in grayscale units were analyzed for average intensity and average curve width. Adults with diabetes mellitus, age-related macular degeneration (ARMD), central serous retinopathy, and retinal dystrophies, as well as healthy control volunteers, were imaged. Monolayers of cultured human retinal pigment epithelial (HRPE) cells, HRPE cells exposed to sublethal doses of H2O2, and HRPE cells exposed to H2O2 in the presence of antioxidants were imaged for FA using fluorescent photomicroscopy.Control patients demonstrated low levels of retinal FA, which increased progressively with age. Diabetics without visible retinopathy demonstrated increased FA levels compared to control volunteers (P.001). Diabetics with retinopathy demonstrated significantly higher FA values than those without retinopathy (P.04). Patients with ARMD, central serous retinopathy, or retinal dystrophies also demonstrated significantly increased FA. Compared to control RPE cells, cells oxidatively stressed with H2O2 had significantly elevated FA (P.05), which was prevented by antioxidants (P.05).Retinal FA is significantly increased with age and diseases known to be mediated by oxidative stress. Retinal FA imaging may provide a novel, noninvasive method of assessing retinal health and retinal dysfunction prior to retinal cell death.

Published
2008

45. CHRONIC RETINAL NECROSIS

Author

Schneider, Eric W., primary, Elner, Susan G., additional, van Kuijk, Frederik J., additional, Goldberg, Naomi, additional, Lieberman, Ronni M., additional, Eliott, Dean, additional, and Johnson, Mark W., additional

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results