Search

Your search keyword '"Els T"' showing total 203 results
Start Over Author "Els T"
203 results on '"Els T"'

2. An Evaluation of Severe Anesthetic-Related Critical Incidents and Risks From the South African Paediatric Surgical Outcomes Study: A 14-Day Prospective, Observational Cohort Study of Pediatric Surgical Patients

Author

Cronjé, Larissa, Torborg, Alexandra M., Meyer, Heidi M., Bhettay, Anisa Z., Diedericks, Johan B.J.S., Cilliers, Celeste, Kluyts, Hyla-Louise, Mrara, Busisiwe, Kalipa, Mandisa N., Cloete, Esther, Burke, Annemie, Mogane, Palesa N., Alphonsus, Christella S., Mbeki, Motselisi, Thomas, Jennifer, Rodseth, Reitze N., Biccard, Bruce M., Allopi, K., Singh, U., Diyelela-Ndwandwa, P., Nongqo, N., Ravid, B., Anamourlis, P., Coetzee, G., Dlamini, M., Foster, C., Nel, D., Oosthuizen, A., Redford, L., Murray, R., Basson, C., Joubert, J., Tshifularo, N., Els, T., Orrock, J., Muthambi, M., Matebesi, T., Tshukudu, G., Maela, D., Allorto, N., Bertie, J., Bishop, D., Chetty, K., Grobbelaar, M., Wise, R., von Steiger, I., Nundlal, P., Garoufalias, E., Westcott, G., Davids, J., Rajah, C., Cairns, C., Mzoneli, Y., Bhagwan, K., Jaworska, M., Semenya, E., Porrill, O., Mungar, R., Seonandan, P., Perumal, N., Bosman, M., De Castro, A., Drummond, L., Du Bruyn, M., Govender, P., Hardcastle, T., Hlangu, Z., Jeena, P., Mbuyisa, M., Naidu, T., Sewlall, J., Taylor, J., Timakia, K., Van der Walt, W., Biyase, T., Khumalo, Z., Kusel, B., Mukama, I., Ramburuth, M., Singaram, S., Schutte, H., Anderson, P., Dorasamy, B., Kint, P., Goga, S., Dube, N., Jithoo, S., Naidoo, L., Naidu, L., Reddy, T., Saman, Y., Rungan, D., Naidoo, K., Kabambi, K., Mgoqo, N., Mofoka, M., Usenbo, A., Chiu, C., Machere, N., Maiwald, D., Davies, G., Serdyn, T., Gokal, P., Dhanjee, N., Wege, M., Govender, S., Tarr, S., Moodley, M., Balkisson, M., Maharaj, A., Ngcobo, S., Rorke, N., Sikhakhane, S., Khumalo, M., Ramsamy, T., Kabongo, K., Kuhn, W., Matos-Puig, R., Naidoo, R., Thotharam, A., Chohan, A., Adam, S., Appel, I., de Vos, C., Gautam, S., Joubert, E., Rautenbach, R., Roytowski, D., Szpytko, A., Brits, E., Naude, G., van Niekerk, J., and Fullerton, Z.

Published
2021
Full Text
View/download PDF

4. South African Paediatric Surgical Outcomes Study: a 14-day prospective, observational cohort study of paediatric surgical patients

Author

Allopi, K., Singh, U., Diyelela-Ndwandwa, P., Nongqo, N., Ravid, B., Anamourlis, P., Coetzee, G., Dlamini, M., Foster, C., Mogane, P., Nel, D., Oosthuizen, A., Redford, L., Murray, R., Basson, C., Joubert, J., Tshifularo, N., Els, T., Kluyts, H., Orrock, J., Muthambi, M., Matebesi, T., Tshukudu, G., Maela, D., Allorto, N., Bertie, J., Bishop, D., Chetty, K., Grobbelaar, M., Wise, R., von Steiger, I., Nundlal, P., Garoufalias, E., Westcott, G., Davids, J., Rajah, C., Rodseth, R., Cairns, C., Mzoneli, Y., Bhagwan, K., Cloete, E., Biccard, B., Jaworska, M., Semenya, E., Porrill, O., Mungar, R., Seonandan, P., Perumal, N., Alphonsus, C., Bosman, M., De Castro, A., Drummond, L., Du Bruyn, M., Govender, P., Hardcastle, T., Hlangu, Z., Jeena, P., Mbuyisa, M., Naidu, T., Sewlall, J., Taylor, J., Timakia, K., Torborg, A., Van der Walt, W., Biyase, T., Khumalo, Z., Kusel, B., Mukama, I., Ramburuth, M., Singaram, S., Mbeki, M., Schutte, H., Anderson, P., Dorasamy, B., Kint, P., Goga, S., Cronjé, L., Dube, N., Jithoo, S., Naidoo, L., Naidu, L., Reddy, T., Saman, Y., Rungan, D., Naidoo, K., Kabambi, K., Mgoqo, N., Mofoka, M., Mrara, B., Usenbo, A., Chiu, C., Machere, N., Maiwald, D., Davies, G., Serdyn, T., Gokal, P., Bhettay, A., Dhanjee, N., Meyer, H., Wege, M., Thomas, J., Govender, S., Tarr, S., Moodley, M., Balkisson, M., Maharaj, A., Ngcobo, S., Rorke, N., Sikhakhane, S., Khumalo, M., Ramsamy, T., Kabongo, K., Kuhn, W., Matos-Puig, R., Naidoo, R., Thotharam, A., Chohan, A., Adam, S., Appel, I., Burke, A., Cilliers, C., de Vos, C., Gautam, S., Joubert, E., Rautenbach, R., Roytowski, D., Szpytko, A., Brits, E., Diedericks, B., Naude, G., van Niekerk, J., Fullerton, Z., Cronje, L., Diedericks, J., and Kalipa, M.

Published
2019
Full Text
View/download PDF

5. Chia Seeds Oil Suppresses the Resistance of Hepatocellular Carcinoma Cells to Liposomal-doxorubicin and Upregulates the Tumor Suppressor miRNAs

Author

Shaimaa A, Tawfik, Els T, Awad, Hoda O, Abu Bakr, Ismail M, Ahmed, Esmat, Ashour, and Amira M, Gamal-Eldeen

Subjects
Pharmaceutical Science, Biotechnology
Abstract

Background: Chia seed is an oil-seed of multiple biological activities. Doxorubicin is an effective chemotherapy for liver cancer. Resistance and adverse effects are doxorubicin limitations. Objective: This study aimed to investigate the effect of chia seeds oil (CSO) on the resistance of HepG2 cells to liposomal-doxorubicin (DOX). Methods: The objective were investigated through measuring cytotoxicity, doxorubicin-metabolizing enzyme Cytochrome P450 3A4 (CYP-3A4), multidrug resistance-associated protein (MRP1), and the expression of multiple tumor suppressor microRNAs. Results: The findings indicated that low concentration of CSO increased HepG2 cells sensitivity to DOX as concluded from its higher cytotoxicity. DOX induced mRNAs of CYP-3A4 and MRP1 and their protein levels. CSO inhibited both in DOX-treated cells. CSO induced tumor suppressor miRNAs. Doxorubicin inhibited miR-122 and let-7/b/e expression, while it led to overexpression of let-7a. CSO/DOX upregulated let-7/b/e, miR-34a, and miR-122 (which inhibits MRP1) and downregulated let-7a that may lead to increased apoptosis. Conclusion: CSO effectively re-sensitized HepG2 cells to liposomal-doxorubicin via inhibiting MRP1 and CYP-3A4 that may increase in vivo doxorubicin bioavailability and decrease its therapeutic dose to diminish its adverse effects.

Published
2023
Full Text
View/download PDF

9. Exploring physiologic reactions to persuasive information

Author

Spelt, Hanne A.A., Asta, Luisa, Kersten-van Dijk, Els T., Ham, Jaap, IJsselsteijn, Wijnand A., Westerink, Joyce H.D.M., Spelt, Hanne A.A., Asta, Luisa, Kersten-van Dijk, Els T., Ham, Jaap, IJsselsteijn, Wijnand A., and Westerink, Joyce H.D.M.

Abstract

Persuasion aims at changing peoples’ motivations and/or behaviors. This study explores how and when physiology reflects persuasion processes and specifically whether individual differences in motivations and behaviors affect psychophysiologic reactions to persuasive information. Participants (N = 70) with medium or high meat consumption patterns watched a persuasive video advocating limited meat consumption, while their electrodermal and cardiovascular physiology was measured. Results indicated that the video increased participants’ moral beliefs, perceived behavioral control, and reduction intentions. This study also found an increase in physiologic arousal during the persuasive video and that people with motivations less aligned to the persuasion objective had more physiologic arousal. The findings encourage further psychophysiologic persuasion research, especially as these insights can potentially be used to personalize persuasive messages of behavior change applications.

Published
2022

10. Longitudinal assessment of sleep and fatigue according to baby feeding method in postpartum women: a prospective observational study

Author

An Mariman, Ignace Hanoulle, Dirk Pevernagie, Sarah-Jane Maertens, Isabelle Dehaene, Els Tobback, Liesbeth Delesie, Anne Loccufier, Ann Van Holsbeeck, Lara Moons, and Dirk Vogelaers

Subjects
Feeding methods, Fatigue, Depression, Sleep quality, Choice behavior, Gynecology and obstetrics, RG1-991
Abstract

Abstract Background Poor subjective sleep quality, depressive symptoms and fatigue occur frequently in postpartum. However, the dynamics of their respective associations from prepartum throughout the maternity period in function of baby feeding method have not been fully elucidated. Methods Prospective, longitudinal study using validated questionnaires probing for sleep quality, insomnia, fatigue and depressive symptoms at 35–37 weeks of gestation and at 2, 8 and 12 weeks postpartum in the obstetric departments of two Flemish hospitals. Somers’d ordinal correlation was used for correlations between the results of questionnaires (ratio variables) and the feeding method variable (an ordinal variable); T tests (normal data) or Mann Whitney (non normal data) tests for equality of means; ordinal regression (‘Proportional odds model’) to investigate the predictive value of parameters at one moment on the feeding method choice at a later moment; logistic regression to investigate the predictive value of parameters on later change of feeding method. Results 188 women indicating a choice for either bottle or breastfeeding in prepartum (27–35 weeks’ gestation) were included. Higher fatigue assessed through the Fatigue Severity Scale within late pregnancy was moderately associated with primary bottle feeding choice. Fatigue decreased at early and late postpartum in bottle feeding (-0.38 ± 1.04; p = .110 and − 0.31 ± 1.01; p = .642 respectively), but remained unchanged from late pregnancy through early and late postpartum in breastfeeding (0.04 ± 1.21; p = .110 and − 0.27 ± 0.96; p = .642 respectively), resulting in similar fatigue in both feeding methods in early through late postpartum. There were no differences in sleep quality or insomnia symptoms at all time points. Presence of postpartum depressive symptoms were associated with early switching to bottle feeding (Somers’ d correlation 0.11 (p = .021). Conclusions Fatigue and depressive symptoms are inversely associated with breastfeeding initiation or maintenance and influence feeding method dynamics.

Published
2024
Full Text
View/download PDF

12. Exploring physiologic reactions to persuasive information

Author

Hanne A. A. Spelt, Luisa Asta, Els T. Kersten‐van Dijk, Jaap Ham, Wijnand A. IJsselsteijn, Joyce H. D. M. Westerink, Human Technology Interaction, EAISI Health, EAISI Foundational, and EAISI Mobility

Subjects
Motivation, Endocrine and Autonomic Systems, InformationSystems_INFORMATIONINTERFACESANDPRESENTATION(e.g.,HCI), Cognitive Neuroscience, General Neuroscience, Persuasive Communication, ComputingMilieux_PERSONALCOMPUTING, Individuality, Experimental and Cognitive Psychology, Intention, Morals, Neuropsychology and Physiological Psychology, InformationSystems_MODELSANDPRINCIPLES, Developmental Neuroscience, Neurology, Humans, InformationSystems_MISCELLANEOUS, Biological Psychiatry
Abstract

Persuasion aims at changing peoples’ motivations and/or behaviors. This study explores how and when physiology reflects persuasion processes and specifically whether individual differences in motivations and behaviors affect psychophysiologic reactions to persuasive information. Participants (N = 70) with medium or high meat consumption patterns watched a persuasive video advocating limited meat consumption, while their electrodermal and cardiovascular physiology was measured. Results indicated that the video increased participants’ moral beliefs, perceived behavioral control, and reduction intentions. This study also found an increase in physiologic arousal during the persuasive video and that people with motivations less aligned to the persuasion objective had more physiologic arousal. The findings encourage further psychophysiologic persuasion research, especially as these insights can potentially be used to personalize persuasive messages of behavior change applications.

Published
2021

14. Why are our medicines so expensive? Spoiler: Not for the reasons you are being told…

Author

Els Torreele

Subjects
Medicine (General), R5-920
Abstract

Often described as a natural economic trend, the prices that pharmaceutical companies charge for new medicines have skyrocketed in recent years. Companies claim these prices are justified because of the ‘value’ new treatments represent or that they reflect the high costs and risks associated with the research and development process. They also claim that the revenues generated through these high prices are required to pay for continued innovation. This paper argues that high prices are not inevitable but the result of a societal and political choice to rely on a for-profit business model for medical innovation, selling medicines at the highest possible price. Instead of focusing on therapeutic advances, it prioritises profit maximisation to benefit shareholders and investors over improving people’s health outcomes or equitable access. As a result, people and health systems worldwide struggle to pay for the increasingly expensive health products, with growing inequities in access to even life-saving medicines while the biopharmaceutical industry and its financiers are the most lucrative business sectors. As the extreme COVID-19 vaccine inequities once again highlighted, we urgently need to reform the social contract between governments, the biopharmaceutical industry, and the public and restore its original health purpose. Policymakers must redesign policies and financing of the pharmaceutical research and development ecosystem such that public and private sectors work together towards the shared objective of responding to public health and patients’ needs, and achieve health equity, rather than maximising financial return. Because medicines should not be a luxury.

Published
2024
Full Text
View/download PDF

18. Elucidating the migrations of European seabass from the southern north sea using mark-recapture data, acoustic telemetry and data storage tags

Author

Jolien Goossens, Mathieu Woillez, Serena Wright, Jena E. Edwards, Georges De Putter, Els Torreele, Pieterjan Verhelst, Emma Sheehan, Tom Moens, and Jan Reubens

Subjects
Medicine, Science
Abstract

Abstract The movement ecology of European seabass, Dicentrarchus labrax, remains poorly understood, especially in the northern ranges of its distribution. To investigate migration patterns of seabass from the southern North Sea, we combined data from different projects from four countries using various tagging techniques. This resulted in 146 recaptures (out of 5598 externally marked seabass), 138 detected animals (out of 162 seabass fitted with an acoustic transmitter) and 76 archived depth and temperature series (out of 323 seabass with an archival tag). Using geolocation modelling, we distinguished different migration strategies, whereby individual fish migrated to the eastern English Channel (15.1%), the western English Channel (28.3%), the Celtic Sea and the norther part of the Bay of Biscay (17.0%), or stayed in the North Sea (39.6%). A high number of seabass exhibited fidelity to the North Sea (90.5% of recaptures, 55.3% for acoustic transmitters and 44.7% of archival tags). Although seabass are generally considered to migrate southwards in winter, a large number of individuals (n = 62) were observed in the southern North Sea, where spawning might potentially occur in a particular deep location along the coast of Norfolk in the UK. Our results highlight the need to consider fine-scaled population structuring in fisheries assessment, and indicate that current seasonal fisheries closures are not aligned with the ecology of seabass in the North Sea.

Published
2024
Full Text
View/download PDF

19. Abstracts

Author

Derlon J. M., Petit-taboué M. C., Dauphin F., Courtheoux P., Chapon F., Creissard P., Darcel F., Houtteville J. P., Kaschten, B., Sadzot, B., Stevenaert, A., Tjuvajev, Juri G., Macapinlac, Homer A., Daghighian, Farhad, Ginos, James Z., Finn, Ronald D., Jiaju Zhang, M. S., Beattie, Bradley, Graham, Martin, Larson, Steven M., Blasberg, Ronald G., Levivier, M., Goldman, S., Pirotte, B., Brucher, J. M., Balériaux, D., Luxen, A., Hildebrand, J., Brotchi, J., Go K. G., Kamman R. L., Mooyaart E. L., Heesters M. A. A. M., Sijens, P. E., Oudksrk, M., van Dijk, P., Levendag, P. C., Vecht, Ch. J., Metz, R. J., Kennedy, D. N., Rosen, B. R., Hochberg, F. H., Fishman, A. J., Filipek, P. A., Caviness, V. S., Gross, M. W., Weinzierl, F. X., Trappe, A. E., Goebel, W. E., Frank, A. M., Becker, Georg, Krone, Andreas, Schmidt, Karsten, Hofmann, Erich, Bogdahn, Ulrich, Bencsch, H., Fclber, S., Finkenstedt, G., Kremser, C., Sfockhammer, G., Aichner, F., Bogdahn U., Fröhlich T., Becker G., Krone A., Schlief R., Schürmann J., Jachimczak P., Hofmann E., Roggendorf W., Roosen K., Carapella, C. M., Carpinelli, G., Passalacqua, R., Raus, L., Giannini, M., Mastrostefano, R., Podo, F., Tofani, A., Maslrostefano, R., Mottoles, M., Ferraironi, A., Scelsa, M. G., Oppido, P., Riccio, A., Maini, C. L., Collombier, L., Taillandier, L., Dcbouverie, M., Laurens, M. H., Thouvenot, P., Weber, M., Bertrand, A., Cruickshank G. S., Patterson J., Hadley D., De Witte, Olivier, Hildebrand, Jerzy, Luxen, André, Goldman, Serge, Ernestus, R. -I., Bockhorst, K., Eis, M., Els, T., Hoehn-Berlage, M., Gliese, M., Fründ, R., Geissler, A., Woertgen, C., Holzschuh, M., Goldman, Serge, Levivier, M., Pirotte, B., Brucher, J. M., Luxen, A., Brotchi, J., Hildebrand, J., Hausmann, O., Merlo, A., Jerrnann, E., Uirich, J., Chiquet-Ehrismann, R., Müller, J., Mäcke, H., Gratzl, O., Herholz, K., Ghaemi, M., Würker, M., Pietrzyk, U., Heiss, W. -D., Kotitschke, K., Brandl, M., Tonn, J. C., Haase, A., Bogdahn, U., Kotitschke, K., Muigg, S., Felber, S., Aichner, F., Haase, A., Bogdahn, U., Krone A., Becker G., Woydt M., Roggendorf W., Hofmann E., Bogdahn U., Roosen K., Lanfermann, Heinrich, Heindel, Walter, Kugel, Harald, Erneslus, Ralf -Ingo, Röhn, Gabricle, Lackner, Klaus, Metz, R. J., Kennedy, D. N., Pardo, F. S., Kutke, S., Sorensen, A. G., Hochberg, F. H., Fishman, A. J., Filipek, P. A., Rosen, B. R., Caviness, V. S., Mechtler, L. L., Withiam-Lench, S., Shin, K., Klnkel, W. R., Patel, M., Truax, B., Kinkel, P., Shin, K., Mechtler, L., Ricci M., Pantano P., Maleci A., Pierallini S., Di Stefano D., Bozzao L., Cantore G. P., Röhn, Gabriele, Els, T., Schröder, R., Hoehn-Berlage, M., Ernestus, R. -I., Ruda, R., Mocellini, C., Soffietti, R., Campana, M., Ropolo, R., Riva, A., de Filippi, P. G., Schiffer, D., Salgado D., Rodrigues M., Salgado L., Fonseca A. T., Vieira M. R., Bravo Marques J. M., Satoh, H., Uozumi, T., Kiya, K., Kurisu, K., Arita, K., Sumida, M., Ikawa, F., Tzuk-Shina, Tz., Gomori, J. M., Rubinstein, R., Lossos, A., Siegal, T., Vaalburg, W., Paans, A. M. J., Willemsen, A. T. M., van Waarde, A., Pruim, J., Visser, G. M., Go, K. G., Valentini, S., Ting, Y. L. T., De Rose, R., Chidichimo, G., Corricro, G., van Lcycn-Pilgram, Karin, Erncslus, Ralf -Ingo, Klug, Norfried, van Leyen-Pilgram, K., Ernestus, R. -I., Schröder, R., Klug, N., Woydt M., Krone A., Tonn J. C., Becker G., Neumann U., Roggendorf W., Roosen K., Plate, Karl H., Breier, Georg, Millaucr, Birgit, Weich, Herbert A., Ullrich, Axel, Risau, Werner, Roosen N., Chopra R. K., Mikkelsen T., Rosenblum S. D., Yan P. S., Knight R., Windham J., Rosenblum M. L., Schiffer, D., Attanasio, A., Cavalla, P., Chio, A., Giordana, M. T., Migheli, A., Amberger, V., Hensel, T., Schwab, M. E., Cervoni, Luigi, Celli, Paolo, Tarantino, Roberto, Huettner, C., Tonn, J. C., Berweiler, U., Roggendorf, W., Salmon, I., Rorive, S., Rombaut, K., Pirotte, B., Haot, J., Brotchi, J., Kiss, R., Maugard-Louboutin C., Charrier J., Fayet G., Sagan C., Cuillioere P., Ricolleau G., Martin S., Menegalli-Bogeelli D., Lajat Y., Resche F., Molnàr, Péter, Bárdos, Helga, Ádány, Róza, Rogers, J. P., Pilkington, G. J., Pollo, B., Giaccone, G., Allegranza, A., Bugiani, O., Prim, J., Badia, J., Ribas, E., Coello, F., Shezen, E., Lossos, A., Abramsky, O., Siegal, T., Scerrati M., Roselli R., Iacoangeli M., Pompucci A., Rossi G. F., Deeb, Saleh M. Al., Koreich, Osama, Yaqub, Basim, Moutaery, Khalaf R. Al., Giordana, M. T., Cavalla, P., Chio, A., Marino, S., Vigliani, M. C., Schiffer, D., Deburghgraeve, V., Darcel, F., Gedouin, D., Hassel, M. Ben, Guegan, Y., Jeremic, B., Grujicic, D., Antunovic, V., Matovic, M., Shibamoto, Y., Kallio, Merja, Huhmar, Helena, Kudoh, Ch., Detta, A., Sugiura, K., Hitchcock, E. R., Mastrostefano, R., Di Russo, R., Cipriani§, M., Occhipinti, E. M., Conti, E. M. S., Clowegeser A., Ortler M., Seiwald M., Kostron H., Rajan B., Ross G., Lim C., Ashlcy S., Goode D., Traish D., Brada M., Sanden, G. A. C. vd, Schouten, L. J., Coebergh, J. W. W., Razenberg, P. P. A., Twijnstra, A., Snilders-Keilholz, A., Voormolen, J. H. C., Hermans, J., Leer, J. W. H., Taillandier, L., Baylac, F., Dcbouvcrie, M., Anxionnal, R., Bracard, S., Vignand, J. M., Duprcz, A., Weber, M., Winking, M., Böker, D. K., Simmet, T., Rothbart, David, Strugar, John, Balledux, Jeroen, Criscuolo, Gregory R., Jachimczak, Piotr, Blesch, Armin, Heβdörfer, Birgit, Bogdahn, Ulrich, Ernestus, Ralf -Ingo, Schröder, Roland, Klug, Norfrid, Krouwer, H. G. J., Duinen, S. G. v., Algra, A., Zentner, J., Wolf, H. K., Ostertun, B., Hufnagel, A., Campos, M. G., Solymosi, L., Schramm, J., Newlands, E. S., O'Reilly, S. M., Brampton, M., Soffietti, R., Chio, A., Mocellini, C., Ruda, R., Vigliani, M. C., Schiffer, D., Sciolla, R., Seliak, D., Henriksson, R., Bergenheim, A. T., Björk, P., Gunnarsson, P. -O., Hariz, Ml., Grant, R., Collie, D., Gregor A., Ebmeier K. P., Jarvis G., Lander F., Cull A., Sellar R., Brada, M., Thomas, C., Elyan, S., Hines, F., Ashley, S., Stenning, S., Bernstein J. J., Goldberg W. J., Roelcke U., Von Ammon K., Hausmann O., Radu E. W., Kaech D., Leenders K. L., Fitzek, II, M. M., Aronen J. Efird, Hochberg, F., Gruber, M., Schmidt, E., Rosen, B., Flschman, A., Pardo, P., Afra U. M. U., Sipos, L., Slouik, F., Boiardi A., Salmaggi A., Pozzi A., Farinotti L., Fariselli L., Silvani A., Brandes, A., Scelzi, E., Rigon, A., Zampieri, P., Pignataro, M., Amanzo, P. D'., Amista, P., Rotilio, A., Fiorentino, M. V., Thomas, R., Brazil, L., O'Connor, A. M., Ashley, S., Brada, M., Salvati, Maurizio, Cervoni, Luigi, Puzzilli, Fabrizio, Cervoni, Luigi, Salvati, Maurizio, Raguso, Michele, Cruickshank G. S., Duckworth R., Rumpling R., Rottuci M., Fariselli L., Boiardi A., Broggi G., Plrint, N. G., Sabattini, E., Manetto, V., Gambacorta, H., Poggi, S., Pileri, S., Ferracini, R., Grant, R., Plev D. V., Hopf N. J., Knosp E., Bohl J., Perncczky A., Kiss, R., Salmon, I., Catnby, I., Dewitte, O., Brotchi, J., Pasteels, J. L., Camby, I., Salmon, I., Darro, F., Danguy, A., Brotchi, J., Pasteels, J. L., Kiss, R., Kiu, M. C., Lai, G. M., Yang, T. S., Ng, K. T., Chen, J. S., Chang, C. N., Leung, W. M., Ho, Y. S., Rychter, M. Deblec, Klimek, A., Liberski, P. P., Karpinaka, A., Krauseneck P., Schöffel V., Müller B., Kreth, F. W., Faist, M., Warnke, P. C., Ostertag, C. B., Nielen, K. M. B. v., Visscr, M. C., Lebrun C., Lonjon M., Desjardin T., Michiels J. F., Chanalet Sa. Lagrange J. L., Roche J. L., Chatel M., Mastronardi L., Puzzilli F., Osman Farah J., Lunardi P., Matsutani, M., Ushio, Y., Takakura, K., Menten, Johan, Hamers, Han, Ribot, Jacques, Dom, René, Tcepen, Hans, Müller B., Weidner N., Krauseneck P., Naujocks, G., van Roost, D., Wiestler, O. D., Kuncz, A., Nieder, C., Setzel-Sesterhein, M., Niewald, M., Schnabel, I., O'Neill, K. S., Kitchen, N. D., Wilkins, P. R., Marsh, H. T., Pierce, E., Doshi, R., Deane, R., Previtali, S., Quattrini, A., Nemni, R., Ducati, A., Wrabetz, L., Canal, N., Punt, C. J. A., Stamatakis, L., Giroux, B., Rutten, E., Quigley, Matthew R., Beth Sargent P. A. -C., Flores, Nicholas, Simon, Sheryl, Maroon, Joseph C., Quigley, Matthew R., Beth Sargent P. A. -C., Flores, Nicholas, Maroon, Joseph C., Rocca A. A., Gervasoni C., Castagna A., Picozzi P., Giugni E., Rocca A. A., Tonnarelli G. P., Ducati A., Mangili F., Truci G., Canal N., Giovanelli M., Roelcke U., Von Ammon K., Radu E. W., Leenders K. L., Sachsenheimer, W., Bimmler, T., Seiwald M., Eiter H. Rhomberg W., Ortler M., Obwegesser A., Kostron H., Steilen H., Henn W., Moringlane J. R., Kolles H., Feiden W., Zang K. D., Sleudel W. I., Steinbrecher, Andreas, Schabet, Martin, Heb, Clemens, Bamberg, Michael, Dichgans, Johannes, Stragliotto, G., Delattre, J. Y., Poisson, M., Zampieri, P., Brandes, A., Rigon, A., Tosatto, L., D'Amanzo, P., Menicucci, N., Rotilio, A., Mingrino, S., Steudel, W. I., Feld, R., Henn, W., Zang, K. D., Maire, J. Ph., Caudry, M., Guerin, J., Celerier, D., Salem, N., Demeaux, H., Fahregat, J. F., Kusak, M. E., Bucno, A., Albisua, J., Jerez, P., Sarasa, J. L., Garefa, R., de Campos, J. M., Kusak, M. E., de Campos, J. M., Bueno, A., García-Delgado, R., Sarasa, J. L., García-Sola, R., Lantsov A. A., Shustova T. I., Lcnartz, D., Wellenreuther, R., von Deirnling, A., Köning, W., Menzel, J., Scarpa, S., Manna, A., Reale, M. G., Oppido, P. A., Carapella, C. M., Frati, L., Valery, C. A., Ichen, M., Foncin, J. P., Soubrane, C., Khayat, D., Philippon, J., Vaz, R., Cruz, C., Weis S., Protopapa D., März R., Winkler P. A., Reulen H. J., Bise K., Beuls E., Berg J., Deinsberger, W., Böker, D. K., Samii, M., Caudry, M., Darrouzet, V., Guérin, J., Trouette, R., Causse, N., Bébéar, J. P., Parker, F., Vallee, J. N., Carlier, R., Zerah, M., Lacroix-Jousselin, C., Piepmeier, Joseph M., Kveton, John, Czibulka, Agnes, Tigliev G. S., Chernov M. P., Maslova L. N., Valdueza, José M., Jänisch, Werner, Bock, Alexander, Harms, Lutz, Bessell, E. M., Graus, F., Punt, J., Firth, J., Hope, T., Koriech, Osama, Al Deeb, Saleh, Al Moutaery, Khalaf, Yaqub, B., Silvani A., Salmaggi A., Pozzi A., Franzini A., Boiardi A., Goldbrunner, R., Warmuth-Metz, M., Paulus, W., Tonn, J. -Ch., Roosen, K., Strik I. I., Müller B., Markert C., Pflughaupt K. -W., Krauseneck P., O'Neill, B. P., Dinapoli, R. P., Voges, J., Sturm, V., Deuß, U., Traud, C., Treuer, H., Lehrke, R., Kim, D. G., Müller, R. P., Alexandrov Yu. S., Moutaery, K., Aabed, M., Koreich, O., Ross, G. M., Rajan, B., Traish, D., Ashley, S., Ford, D., Brada, M., Schmeets, I. L. O., Jager, J. J., Pannebakker, M. A. G., de Jong, J. M. A., van Lindert, E., Knosp, E., Kitz, K., Blond, S., Dubois, F., Assaker, R., Baranzelli, M. C., Sleiman, M., Pruvo, J. P., Coche-Dequeant, B., Matsutani M., Takakura K., Sano K., PetriČ-Grabnar, G., Jereb, B., Župančič, N., Koršič, M., Rainov N. G., Burkert W., Ushio, Yukitaka, Kochi, Masato, Itoyama, Youichi, de Campos, J. M., Kusak, M. E., Sarasa, J. L., García, R., Bueno, A., Ferrando, L., Hoang-Xuan, K., Sanson, M., Merel, P., Delattre, J. Y., Poisson, M., Delattre, O., Thomas, G., Hoang-Xuan, K., Delattre, J. Y., Poisson, M., Thomas, G., Haritz, D., Obersen, B., Grochulla, F., Gabel, D., Haselsberger K., Radner H., Pendl G., Brada, M., Laing, R. W., Warrington, A. P., Nowak, P. J. C. M., Kolkman-Deurloo, I. K. K., Visser, A. G., Berge, Hv. d., Niël, C. G. J. H., Levendag, P. C., Bergström P., Hariz M., Löfroth P. -O., Bergenheim T., Henriksson R., Blond, S., Assaker, R., Cortet-rudelli, C., Dewailly, D., Coche-dequeant, B., Castelain, B., Dinapoli, R., Shaw, E., Coffey, R., Earle, J., Foote, R., Schomberg, P., Gorman, D., Girard N., Courel M. N., Delpech B., Haselsberger K., Friehs G. M., Schröttner O., Pendl G., Pötter, R., hawliczek, R., Sperveslage, P., Prott, F. J., Wachter, S., Dieckmann, K., Würker, M., Herholz, K., Pietrzyk, U., Voges, J., Treuer, H., Sturm, V., Bauer, B., Heiss, W. -D., Jund, R., Zimmermann, F., Feldmann, H. J., Gross, M. W., Kneschaurek, P., Molls, M., Lederman, G., Lowry, J., Wertheim, S., Voulsinas, L., Fine, M., Lederman, G., Lowry, J., Wertheim, S., Fine, M., Voutsinas, I., Qian, G., Rashid, H., Lederman, G., Lowry, J., Wertheim, S., Fine, M., Voulsinas, L., Qian, G., Rashid, H., Moutaery, K., Aabed, M., Koreich, O., Scerrati M., Montemaggi P., Iacoangeli M., Pompucci A., Roselli R., Trignani R., Rossi G. F., Shin, K., Mechtler, L., West, C., Grand, W., Shin, K., Sibata, C., West, C., Mechtler, L., Grand, W., Thomas, R., Guerrero, D., James, N., Ashley, S., Gregor, A., Brada, M., Voges, J., Sturm, V., Bramer, R., Pahlke, H., Lehrke, R., Treuer, H., Banik, N., Kim, D. G., Hövels, M., Bernsen H. J. J. A., Rijken P. F. J. W., Van der Sanden B. P. J., Hagemeier N. E. M., Van der Kogel A. J., Koehler P. J., Verbiest H., Jager J., Vecht Ch. J., Ross G. M., McIlwrath A., Brown R., Mottolesb, C., Pierre'Kahn, A., Croux, M., Roche, J. L., Marchai, J., Delhemes, P., Tremoulet, M., Stilhart, B., Chazai, J., Caillaud, P., Ravon, R., Passacha, J., Bouffet, E., Dirven C. M. F., Mooy J. J. A., Molenaar W. M., Lewandowicz, G. M., Grant, N., Harkness, W., Hayward, R., Thomas, D. G. T., Darling, J. L., Delepine, N., Subovici I. I., Cornille B., Markowska S., Alkallaf JC. Desbois, KühI, J., Niethammer, D., Spaar, H. J., Gnekow, A., Havers, W., Berthold, F., Graf, N., Lampert, F., Maass, E., Mertens, R., Schöck, V., Aguzzi, A., Boukhny, A., Smirtukov, S., Prityko, A., Hoiodov, B., Geludkova, O., Nikanorov, A., Levin, P., Rothbart, David, Balledux, Jeroen, Criscuolo, Gregory R., D'haen, B., Van Calenbergh, F., Casaer, P., Dom, R., Menten, J., Goffin, J., Plets, C., Hertel, A., Hernaiz, P., Seipp, C., Siegler, K., Baum, R. P., Maul, F. D., Schwabe, D., Jacobi, G., Kornhuber, B., Hör, G., Menten, J., Casaer, P., Pilkington, G. J., Merzak, A., Rooprai, H. K., Bullock, P., van Domburg P. H. M. F., Wesseling P., Thijssen H. O. M., Wolff, J. E. A., Boos, J., Krähling, K. H., Gressner-Brocks, V., Jürgens, H., Schlegel, J., Scherthan, H., Arens, N., Stumm, Gabi, Kiessling, Marika, Merzak, A., Koochekpour, S., Pilkington, G. J., Reifenberger, G., Reifenberger, J., Liu, L., James, C. D., Wechsler, W., Collins, V. P., Fabel-Schulte, Klaus, Jachimczak, Plotr, Heßdörfer, Birgitt, Baur, Inge, Schlingensiepen, Karl -Hermann, Brysch, Wolgang, Bogdahn, Ulrich, Blesch A., Bosserhoff A. K., Apfel R., Lottspeich F., Jachimczak P., Büttner R., Bogdahn U., Cece, R., Barajon, I., Tazzari, S., Cavaletti, G., Torri-Tarelli, L., Tredici, G., Hecht, B., Turc-Carel, C., Atllas, R., Chatel, M., Gaudray, P., Gioanni, J., Hecht, F., Balledux, Jeroen, Rothbart, David, Criscuolo, Gregory R., de Campos, J. M., Kusak, M. E., Rey, J. A., Bello, M. J., Sarasa, J. L., Dubois, F., Blond, S., Parent, M., Assaker, R., Gosselin, P., Christiaens, J. L., Feld, R., Moringlane, J. R., Steudel, W. I., Schaudies, J. R., Janka M., Tonn J. C., Fischer U., Meese E., Roosen K., Remmelink, M., Salmon, I., Cras, P., Pasteels, J. L., Brotchi, J., Kiss, R., Bensadoun R. J., Frenay M., Formento J. L., Milano G., Lagrange J. L., Grellier P., Lee, J. -Y., Ernestus, R. -I., Riese, H. -H., Cervós-Navarro, J., Reutter, W., Lippitz, B., Scheitinger, C., Scholz, M., Weis, J., Gilsbach, J. M., Füzesi, L., Koochekpour, S., Merzak, A., Pilkington, G. J., Sanson, M., Li, Y. J., Hoang-Xuan, K., Delattre, J. Y., Poisson, M., Hamelin, R., Van de Kelft, Erik, Dams, Erna, Martin, Jean -Jacques, Willems, Patrick, Lehrke R., Voges J., Treuer H., Erdmann J., Müller R. P., Sturm V., Wurm R. E., Warrington A. P., Laing R. W., Sardell S., Hines F., Graham J. D., Brada M., Ushio, Yukitaka, Kuratsu, Jun -ichi, Kochi, Masato, Kitz K., Aichholzer M., Rössler K., Alesch F., Ertl A., Sorensen, P. S., Helweg-Larsen, S., Mourldsen, H., Hansen, H. H., El Sharoum, S. Y., Berfelo, M. W., Theunissen, P. H. M. H., Jager, J. J., de Jong, J. M. A., Fedorcsák, I., Nyáry, I., Osztie, É., Horvath, Á., Kontra, G., Frenay M., Burgoni-chuzel J., Paquis P., Lagrange J. L., Helweg-Larsen, S., Hansen, SW., Sørensen, PS., Salmon, I., Kiss, R., Krauseneck P., Müller B., Morche M., Tonn J. C., Lagerwaard, F. J., Levendag, P. C., Eijkenboom, W. M. H., Schmilz, P. I. M., Lentzsch S., Weber F., Franke J., Dörken B., Lunardi P., Schettini G., Osman Farah J., Qasho R., Mocellini, C., Ruda, R., Soffietti, R., Garabello, D., Sales, S., De Lucchi, R., Vasario, E., Schiffer, D., Muracciole, X., Régis, J., Manera, L., Peragut, J. C., Juin, P., Sedan, R., Nieder, C., Niewald, M., Walter, K., Schnabel, K., Nieder, C., Niewald, N., Nestle, U., Schnabel, K., Berberich, W., Oschmann, P., Theißen R. D., Reuner K. H., Kaps M., Dorndorf W., Martin, K. K., Akinwunmi, J., Rooprai, H. K., Kennedy, A., Linke, A., Ognjenovic, N., Pilkington, G. J., Svadovsky A. I., Peresedov V. V., Bulakov A. A., Butyalko M. Y., Zhirnova I. G., Labunsky D. A., Gnazdizky V. V., Gannushkina I. V., Taphoorn, M. J. B., Potman, R., Barkhof, F., Weerts, J. G., Karim, A. B. M. F., Heimans, J. J., van de Pol, M., van Aalst, V. C., Wilmink, J. T., Twijnstra, A., van der Sande, J. J., Boogerd, W., Kröger, R., Jäger A., Wismeth C., Dekant A., Brysch W., Schlingensiepen K. H., Jachimczak P., Bogdahn U., Pirolte, B., Cool, V., Gérard, C., Levivier, M., Dargent, J. L., Goldman, S., Brotchi, J., Hildebrand, J., Velu, T., Herrlinger, U., Schabet, M., Ohneseit, P., Buchholz, R., Zhu, Jianhong, Reszka, Regina, Weber, Friedrich, Walther, Wolfgang, Zhang, L. I., Brock, Mario, Roosen N., Rock J. P., Zeng H., Feng J., Fenstermacher J. D., Rosenblum M. L., Siegal, T., Gabizon, A., Beljanski M., Crochet S., Bergenheim, A. T., Zackrisson, B., Elfverson, J., Bergström, P., Henriksson, R., Butti, G., Baetta, R., Magrassi, L., De Renzis, M. R., Soma, M. R., Davegna, C., Pezzotta, S., Paoletti, R., Fumagalli, R., Infuso, L., Sankar, A. A., Darling, J. L., Thomas, D. G. T., Defer, G. -L., Brugières, P., Gray, F., Chomienne, C., Poirier, J., Degos, L., Degos, J. D., Colombo, Bruno M., DiDonato, Stefano, Finocchiaro, Gaetano, Hebeda, K. M., Sterenborg, H. J. C. M., Saarnak, A. E., Wolbers, J. G., van Gemert, M. J. C., Kaaijk P., Troost D., Leenstra S., Das P. K., Bosch D. A., Kostron H., Hochleitner B. W., Obwegeser A., Ortler M., Seiwald M., Vooys, W., Krouwer, H. G. J., de Gast, G. C., Marx, J. J. M., Osman Farah J., Lunardi P., Puzzilli F., Menovsky, T., Beek, J. F., Wolbers, J. G., van Gemert, M. J. C., Naujocks, G., Wiestler, O. D., Schirrmacher, V., Schramm, J., Schmitz, A., Eis-Hübinger, A. M., Piepmeier, p. h., Pedersen, Patricia, Greer, Charles, Quigley, Matthew R., Shih, Tommy, Elrifal, Amr, Rothfus, William, Maroon, Joseph C., Rohertson, L., Rampling, R., Whoteley, T. L., Piumb, J. A., Kerr, D. J., Falina, P. A., Crossan, I. M., Roosen N., Rock J. P., Feng J., Zeng H., Ho K. L., Fenstermacher J. D., Rosenblum M. L., Ruchoux, M. M., Vincent, S., Jonca, F., Plouet, J., Lecomte, M., Samid, D., Thibault, A., Ram, Z., Oldfield, E. H., Myers, C. E., Reed, E., Schabet, M., Herrlinger, U., Buchholz, R., Shoshan, Y., Siegal, T., Siegal, T., Shezen, E., Siegal, Tz., Stockhammer, G., Rosenblum, M., Samid, D., Lieberman, F., Terzis, A. J. A., Bjerkvig, R., Laerum, O. D., Arnold, H., Thibault, A., Samid, D., Figg, W. D., Myers, C. E., Reed, E., Thomas, R., Flux, G., Chittenden, S., Doshi, P., Brazil, L., Thomas, D. G. T., Bignor, D., Zalutsky, M., Brada, M., Tjuvajev, Juri, Kaplitt, Michael, Desai, Revathi, Bradley, M. S., Bettie B. S., Gansbacher, Bernd, Blasberg, Ronald, Haugland, H. K., Saraste, J., Rooseni, K., Laerum, O. D., Vincent, A. J. P. E., Avezaat, C. J. J., Bout, A., Noteboom, J. L., Vecht, C. h., Valerio, D., Hoogerbrugge, P. M., Weber, F., Reszka, R., Zhu, J., Walther, W., List, J., Schulz, W., Wolbers, J. G., Sterenborg, I. I. J. C. M., Kamphorst, W., van Gemert, M. J. C., van Alplien, H. A. M., Salander P., Bergenheim T., Henriksson R., Grant, R., Brazil, L., Thomas, R., Guerrero, D., Laing, R., Ashley, S., Brada, M., Schmidt B., Bauer B., Grau G., Bohnstedt, T., Frydrych A., Franz K., Lorenz R., Brandes, A., Amanzo, P. D'., Zampieri, P., Rigon, A., Scelzi, E., Rotilio, A., Berti, F., Paccagnella, A., Fiorentino, M. V., Müller B., Krauseneck P., van Deventer, P. L., Dellemijn, P. L. I., van den Bent, M. J., Vecht, Ch. J., Kansen, P. J., Tredici, G., Petruccioli, N. G., Cavaletti, G., Cavalletti, E., Kiburg, B., Müller, L. J., Moorer-van Delft, C. M., Heimans, J. J., Boer, H. H., Pace A., Bove L., Pietrangeli A., Innocenti P., Aloe A., Nardi M., Jandolo B., Kellie S. J., De Graaf S. S. N., Bloemhof H., Roebuck D., Dalla Pozza L., Uges D. D. R., Johnston I., Besser M., Chaseling R. A., Koeppen, S., Gründemann, S., Lossos, A., Siegal, T., Nitschke M., Vieregge P., Reusche E., Rob P., Kömpf D., Postma, T. J., Vermorken, J. B., Heimans, J. J., Rampling R. P., Dunlop D. J., Steward M. S., Campbell S. M., Roy S., Hilkens, P. H. E., Verweij, J., van Putten, W. L. J., Vecht, Ch. J., van den Bent, M. J., Hilkens, P. H. E., Moll, J. W. B., van der Burg, M. E. L., Planting, A. S. T., van Putten, W. L. J., Vecht, Ch. J., van den Bent, M. J., Wondrusch E., Zifko U., Drlicek M., Liszka U., Grisold W., Zifko U., Fazeny B., Dittrich Ch., Wondrusch E., Grisold W., Verschuuren, Jan J., Meneses, Patricio I., Rosenfeld, Myrna R., Kaplitt, Michael G., Posner, Jerome B., Dalmau, Josep, Sillevis Smitt P. A. E., Manley G., Posner J. B., Cavaletti, G., Bogliun, G., Margorati, L., Bianchi, G., Drlicek, M., Liska, U., Casati, B., Kolig, C., Grisold, H., Graus, F., Reñe, R., Uchuya, M., Valldeoriola, F., Delattre, J. Y., Benedetti de Cosentiro C., Ortale D., Martinez R., Lambre J., Cagnolati S., Vinai C., Salmaggi A., Nemni R., Silvani A., Forno M. G., Luksch R., Confalonieri P., Boiardi A., Nitschke M., Scholz J., Vieregge P., Kömpf D., Hochberg F. H., Pfeiffer, G., Netzer, J., Hansen, Ch., Eggers, Ch., Hagel Ch., Kunze, K., Verschuuren, Jan J., Rosenblum, Marc K., Lieberman, Frank S., Posner, Jerome B., and Dalmau, Josep

Published
1994
Full Text
View/download PDF

21. Chia Seeds Oil Suppresses the Resistance of Hepatocellular Carcinoma Cells to Liposomal-doxorubicin and Upregulates the Tumor Suppressor miRNAs

Author

Tawfik, Shaimaa A., Awad, Els T., Abu Bakr, Hoda O., Ahmed, Ismail M., Ashour, Esmat, and Gamal-Eldeen, Amira M.

Abstract

Background: Chia seed is an oil seed with multiple biological activities. Doxorubicin is effective chemotherapy for liver cancer. Resistance and adverse effects are doxorubicin limitations. Objective: This study aimed to investigate the effect of chia seeds oil (CSO) on the resistance of HepG2 cells to liposomal-doxorubicin (DOX). Methods: The objective were investigated through measuring cytotoxicity, doxorubicin-metabolizing enzyme Cytochrome P450 3A4 (CYP-3A4), multidrug resistance-associated protein (MRP1), and the expression of multiple tumor suppressor microRNAs. Results: The findings indicated that low concentration of CSO increased HepG2 cells' sensitivity to DOX, as concluded from its higher cytotoxicity. DOX-induced mRNAs of CYP-3A4 and MRP1 and their protein levels. CSO inhibited both in DOX-treated cells. CSO-induced tumor suppressor miRNAs. Doxorubicin inhibited miR-122 and let-7/b/e expression, while it led to overexpression of let- 7a. CSO/DOX upregulated let-7/b/e, miR-34a, and miR-122 (which inhibits MRP1) and downregulated let-7a, which may lead to increased apoptosis. Conclusion: CSO effectively re-sensitized HepG2 cells to liposomal-doxorubicin via inhibiting MRP1 and CYP-3A4, which may increase in vivo doxorubicin bioavailability and decrease its therapeutic dose to diminish its adverse effects.

Published
2023
Full Text
View/download PDF

23. Subpulmonary ventricular function and inflammation are related to clinical heart failure in patients with a systemic right ventricle

Author

Valérie Spalart, Aleksandra Cieplucha, Werner Budts, Pieter De Meester, Els Troost, Thilo Witsch, Walter Droogne, Lucas NL Van Aelst, Magalie Ladouceur, Kimberly Martinod, and Alexander Van De Bruaene

Subjects
Systemic right ventricle, Subpulmonary left ventricle, Systemic left ventricle, Heart failure, Echocardiography, Inflammation, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: Timely diagnosis of heart failure (HF) in patients with a systemic right ventricle (sRV) is difficult but important since clinical deterioration is fast once HF develops. We aimed to compare echocardiography and biomarker profile between sRV patients with and without HF and patients with a systemic left ventricle diagnosed with HF (sLV-HF). Methods and results: Eighty-seven sRV patients and 30 sLV-HF patients underwent echocardiographic evaluation and blood sampling. Compared to sRV patients without HF, sRV-HF patients had more remodeling of the subpulmonary LV (spLV) (internal diameter 3.9 cm [3.3–5.7] vs 3.4 cm [2.9–3.9], P = 0.03, posterior wall 0.93 cm [0.76–1.20] vs 0.71 cm [0.59–0.91], P = 0.006) and lower spLV systolic function: ejection fraction (59 % ± 14 vs 70 % ± 10, P = 0.011), mitral annular plane systolic excursion (1.7 cm ± 0.5 vs 2.1 cm ± 0.4, P = 0.003), fractional area change (47 % [38–58] vs 59 % [51–70], P = 0.002) and lateral strain rate (−1.2/s ± 0.46 vs −1.5/s ± 0.39, P = 0.016). Inflammatory biomarkers were higher in sRV-HF patients compared to those without HF: red cell distribution width (13.3 fL [12.8–14.1] vs 12.6 fL [12.3–13.1], P

Published
2024
Full Text
View/download PDF

24. What Works to Retain Beginning Teachers in the Profession? A Mixed Methods Approach to Detect Determining Factors

Author

Muhammet Safa Göregen, Els Tanghe, and Wouter Schelfhout

Subjects
beginning teachers, teacher retention and attrition, supportive school context, school policy development, teacher retention effectiveness, mixed methods research, Education
Abstract

This study investigates the determinants of teacher retention, focusing on the Flemish region of Belgium, where early-career teacher attrition presents a significant challenge. Employing a mixed methods approach, the research combines quantitative survey data (N = 133) and qualitative interviews (N = 12) to examine variables related to initial guidance (general support, learning and sharing with colleagues, mentoring) and the supportive school context (sense of belonging at school, cooperation, clear goals and support, appreciative school leadership). The findings demonstrate that key elements within the supportive school context—particularly sense of belonging, cooperation, clear goals, and appreciative leadership—have a positive influence on teacher retention. Conversely, general support within initial guidance exhibits a comparatively weaker predictive value. The qualitative analysis reveals inconsistencies in the provision and quality of initial guidance support across schools, which adversely impacts teachers’ professional integration and job satisfaction. The study concludes that the implementation of structured support systems, well-defined goals, and appreciative leadership are critical for improving retention rates. These findings underscore the necessity for schools to adopt both individualized and institutional strategies to address early-career teacher attrition effectively.

Published
2024
Full Text
View/download PDF

31. Multilingualism in performance appraisal interviews: strategies to bridge language gaps

Author

Fien De Malsche, Els Tobback, and Mieke Vandenbroucke

Subjects
performance appraisal, workplace multilingualism, miscommunication, English as a lingua franca, receptive multilingualism, lay interpreting, Communication. Mass media, P87-96
Abstract

This paper explores three multilingual strategies to bridge the lack of a shared first language as they are used during performance appraisal interviews, namely English as a business lingua franca, receptive multilingualism, and a lay interpreter. The study is based on authentic video-recorded performance appraisal interviews at a globally active Belgian company, and follow-up interviews with the managers. The analysis focuses on how the company deals with multilingualism from a management perspective, how the managers perceive these multilingual strategies from a language ideological perspective, and how these language ideological beliefs shape the language practices of the performance appraisal interviews. We conclude that this study provides novel insights into how globalized companies deal with multilingualism in the high-stakes and potentially sensitive interactional context of a performance appraisal interview by underlining the intertwined nature of language ideological beliefs and language practices as part of a broader multilingual language management strategy.

Published
2024
Full Text
View/download PDF

34. Mpox: Neglect has led to a more dangerous virus now spreading across borders, harming and killing people. Leaders must take action to stop mpox now.

Author

Christine McNab, Els Torreele, Ayoade Alakija, Aggrey Aluso, Mauricio Cárdenas, Brendan Crabb, Mark Dybul, Patricia J Garcia, Lawrence O Gostin, Angel Gurría, Jane Halton, Adam Kamradt-Scott, Michel Kazatchkine, Helena Legido-Quigley, Joanne Liu, Suman Majumdar, Henry E Mark, Rosemary McCarney, David Miliband, Winnie Mpanju-Shumbusho, Selina Namchee Lo, Anders Nordström, Raj Panjabi, Jorge Saavedra, Nina Schwalbe, Barbara M Stocking, Eloise Todd, Clare Wenham, Ellen Johnson Sirleaf, and Helen Clark

Subjects
Public aspects of medicine, RA1-1270
Published
2024
Full Text
View/download PDF

37. South African Paediatric Surgical Outcomes Study: a 14-day prospective, observational cohort study of paediatric surgical patients

Author

Torborg, A., primary, Cronje, L., additional, Thomas, J., additional, Meyer, H., additional, Bhettay, A., additional, Diedericks, J., additional, Cilliers, C., additional, Kluyts, H., additional, Mrara, B., additional, Kalipa, M., additional, Rodseth, R., additional, Biccard, B., additional, Allopi, K., additional, Singh, U., additional, Diyelela-Ndwandwa, P., additional, Nongqo, N., additional, Ravid, B., additional, Anamourlis, P., additional, Coetzee, G., additional, Dlamini, M., additional, Foster, C., additional, Mogane, P., additional, Nel, D., additional, Oosthuizen, A., additional, Redford, L., additional, Murray, R., additional, Basson, C., additional, Joubert, J., additional, Tshifularo, N., additional, Els, T., additional, Orrock, J., additional, Muthambi, M., additional, Matebesi, T., additional, Tshukudu, G., additional, Maela, D., additional, Allorto, N., additional, Bertie, J., additional, Bishop, D., additional, Chetty, K., additional, Grobbelaar, M., additional, Wise, R., additional, von Steiger, I., additional, Nundlal, P., additional, Garoufalias, E., additional, Westcott, G., additional, Davids, J., additional, Rajah, C., additional, Cairns, C., additional, Mzoneli, Y., additional, Bhagwan, K., additional, Cloete, E., additional, Jaworska, M., additional, Semenya, E., additional, Porrill, O., additional, Mungar, R., additional, Seonandan, P., additional, Perumal, N., additional, Alphonsus, C., additional, Bosman, M., additional, De Castro, A., additional, Drummond, L., additional, Du Bruyn, M., additional, Govender, P., additional, Hardcastle, T., additional, Hlangu, Z., additional, Jeena, P., additional, Mbuyisa, M., additional, Naidu, T., additional, Sewlall, J., additional, Taylor, J., additional, Timakia, K., additional, Torborg, A., additional, Van der Walt, W., additional, Biyase, T., additional, Khumalo, Z., additional, Kusel, B., additional, Mukama, I., additional, Ramburuth, M., additional, Singaram, S., additional, Mbeki, M., additional, Schutte, H., additional, Anderson, P., additional, Dorasamy, B., additional, Kint, P., additional, Goga, S., additional, Cronjé, L., additional, Dube, N., additional, Jithoo, S., additional, Naidoo, L., additional, Naidu, L., additional, Reddy, T., additional, Saman, Y., additional, Rungan, D., additional, Naidoo, K., additional, Kabambi, K., additional, Mgoqo, N., additional, Mofoka, M., additional, Usenbo, A., additional, Chiu, C., additional, Machere, N., additional, Maiwald, D., additional, Davies, G., additional, Serdyn, T., additional, Gokal, P., additional, Dhanjee, N., additional, Wege, M., additional, Govender, S., additional, Tarr, S., additional, Moodley, M., additional, Balkisson, M., additional, Maharaj, A., additional, Ngcobo, S., additional, Rorke, N., additional, Sikhakhane, S., additional, Khumalo, M., additional, Ramsamy, T., additional, Kabongo, K., additional, Kuhn, W., additional, Matos-Puig, R., additional, Naidoo, R., additional, Thotharam, A., additional, Chohan, A., additional, Adam, S., additional, Appel, I., additional, Burke, A., additional, de Vos, C., additional, Gautam, S., additional, Joubert, E., additional, Rautenbach, R., additional, Roytowski, D., additional, Szpytko, A., additional, Brits, E., additional, Diedericks, B., additional, Naude, G., additional, van Niekerk, J., additional, and Fullerton, Z., additional

Published
2019
Full Text
View/download PDF

38. Dutch Foreign Language Teaching Policy in a European Perspective.

Author

Van Els, T. J. M.

Abstract

Focuses on the changes necessary in Dutch foreign language teaching policies. Cites the need for a greater differentiation of objectives in learning languages. The relevance of the European context to these policies suggests international communication as one essential goal, whether the approach involves multilingualism or a small number of designated working languages. (SL)

Published
1983

40. Acoustic and archival technologies join forces: A combination tag

Author

Jolien Goossens, Mathieu Woillez, Arnault LeBris, Pieterjan Verhelst, Tom Moens, Els Torreele, and Jan Reubens

Subjects
acoustic telemetry, data storage tag, electronic tagging, geolocation model, movement ecology, Ecology, QH540-549.5, Evolution, QH359-425
Abstract

Abstract Technological advances are key to maximizing the information potential in electronic tagging studies. Acoustic tags inform on the location of tagged animals when they are in the range of an acoustic receiver, whereas archival tags render continuous time series of logged sensor measurements, from which trajectories can be inferred. We applied a newly developed acoustic data storage tag (ADST) on 154 animals of three fish species to investigate the potential of this combination tag. Fish trajectories were reconstructed from logged depth and temperature histories using an existing geolocation modelling approach, adapted to include a likelihood for acoustic detections. Out of 126 detected fish (accounting for over 700,000 detections) and 25 tag recoveries, eight ADSTs rendered both acoustic and archival data. These combined data could validate that the original geolocation model performed adequately in locating the fish trajectories in space. The acoustic data improved the timing of the daily position estimates. Acoustic and archival tagging technologies provided highly complementary information on fish movement patterns and could partly overcome the limitations of either technique. Furthermore, the ongoing developments to acoustically transmit summary statistics of logged data would further increase the information potential of combination tags when tracking aquatic species.

Published
2023
Full Text
View/download PDF

42. Sniffing out safety: canine detection and identification of SARS-CoV-2 infection from armpit sweat

Author

Chris Callewaert, Maria Pezavant, Rony Vandaele, Bart Meeus, Ellen Vankrunkelsven, Phaedra Van Goethem, Alain Plumacker, Benoit Misset, Gilles Darcis, Sonia Piret, Lander De Vleeschouwer, Frank Staelens, Kristel Van Varenbergh, Sofie Tombeur, Anouck Ottevaere, Ilke Montag, Patricia Vandecandelaere, Stijn Jonckheere, Linos Vandekerckhove, Els Tobback, Gregoire Wieers, Jean-Christophe Marot, Kurt Anseeuw, Leen D’Hoore, Sebastiaan Tuyls, Brecht De Tavernier, Julie Catteeuw, Ali Lotfi, Alexey Melnik, Alexander Aksenov, Dominique Grandjean, Miguel Stevens, Frank Gasthuys, and Hugues Guyot

Subjects
COVID-19, detection dogs, GC/MS (gas chromatograph/mass spectrometry), acceptability analysis, odor, axilla, Medicine (General), R5-920
Abstract

Detection dogs were trained to detect SARS-CoV-2 infection based on armpit sweat odor. Sweat samples were collected using cotton pads under the armpits of negative and positive human patients, confirmed by qPCR, for periods of 15–30 min. Multiple hospitals and organizations throughout Belgium participated in this study. The sweat samples were stored at −20°C prior to being used for training purposes. Six dogs were trained under controlled atmosphere conditions for 2–3 months. After training, a 7-day validation period was conducted to assess the dogs’ performances. The detection dogs exhibited an overall sensitivity of 81%, specificity of 98%, and an accuracy of 95%. After validation, training continued for 3 months, during which the dogs’ performances remained the same. Gas chromatography/mass spectrometry (GC/MS) analysis revealed a unique sweat scent associated with SARS-CoV-2 positive sweat samples. This scent consisted of a wide variety of volatiles, including breakdown compounds of antiviral fatty acids, skin proteins and neurotransmitters/hormones. An acceptability survey conducted in Belgium demonstrated an overall high acceptability and enthusiasm toward the use of detection dogs for SARS-CoV-2 detection. Compared to qPCR and previous canine studies, the detection dogs have good performances in detecting SARS-CoV-2 infection in humans, using frozen sweat samples from the armpits. As a result, they can be used as an accurate pre-screening tool in various field settings alongside the PCR test.

Published
2023
Full Text
View/download PDF

43. Efficacy and safety of camostat mesylate in early COVID-19 disease in an ambulatory setting: a randomized placebo-controlled phase II trial

Author

Els Tobback, Sophie Degroote, Sabine Buysse, Liesbeth Delesie, Lucas Van Dooren, Sophie Vanherrewege, Cyril Barbezange, Veronik Hutse, Marta Romano, Isabelle Thomas, Elizaveta Padalko, Steven Callens, and Marie-Angélique De Scheerder

Subjects
Camostat, COVID-19, Efficacy, Neutralizing antibodies, Randomized controlled trial, Safety, Infectious and parasitic diseases, RC109-216
Abstract

Objectives: This study aimed to assess the efficacy and safety of 300 mg camostat mesylate three times daily in a fasted state to treat early phase COVID-19 in an ambulatory setting. Methods: We conducted a phase II randomized controlled trial in symptomatic (maximum 5 days) and asymptomatic patients with confirmed COVID-19 infection. Patients were randomly assigned in a 2:1 ratio to receive either camostat mesylate or a placebo. Outcomes included change in nasopharyngeal viral load, time to clinical improvement, the presence of neutralizing antibodies, and safety. Results: Of 96 participants randomized between November 2020 and June 2021, analyses were performed on the data of 90 participants who completed treatment (N = 61 camostat mesylate, N = 29 placebo). The estimated mean change in cycle threshold between day 1 and day 5 between the camostat and placebo group was 1.183 (P = 0.511). The unadjusted hazard ratio for clinical improvement in the camostat group was 0.965 (95% confidence interval, 0.480-1.942, P = 0.921 by Cox regression). The percentage distribution of the 50% neutralizing antibody titer at day 28 visit and frequency of adverse events were similar between the two groups. Conclusion: Under this protocol, camostat mesylate was not found to be effective as an antiviral drug against SARS-CoV-2.Trial registration: ClinicalTrials.gov NCT04625114; November 12, 2020.

Published
2022
Full Text
View/download PDF

44. Taking the time for range testing: an approach to account for temporal resolution in acoustic telemetry detection range assessments

Author

Jolien Goossens, Jolien Buyse, Stijn Bruneel, Pieterjan Verhelst, Peter Goethals, Els Torreele, Tom Moens, and Jan Reubens

Subjects
Animal tracking, Biotelemetry, Detection probability, Presence/absence, Study design, System performance, Ecology, QH540-549.5, Animal biochemistry, QP501-801
Abstract

Abstract Background In acoustic telemetry studies, detection range is usually evaluated as the relationship between the probability of detecting an individual transmission and the distance between the transmitter and receiver. When investigating animal presence, however, few detections will suffice to establish an animal’s presence within a certain time frame. In this study, we assess detection range and its impacting factors with a novel approach aimed towards studies making use of binary presence/absence metrics. The probability of determining presence of an acoustic transmitter within a certain time frame is calculated as the probability of detecting a set minimum number of transmissions within that time frame. We illustrate this method for hourly and daily time bins with an extensive empirical dataset of sentinel transmissions and detections in a receiver array in a Belgian offshore wind farm. Results The accuracy and specificity of over 84% for both temporal resolutions showed the developed approach performs adequately. Using this approach, we found important differences in the predictive performance of distinct hypothetical range testing scenarios. Finally, our results demonstrated that the probability of determining presence over distance to a receiver did not solely depend on environmental and technical conditions, but would also relate to the temporal resolution of the analysis, the programmed transmitting interval and the movement behaviour of the tagged animal. The probability of determining presence differed distinctly from a single transmission’s detectability, with an increase of up to 266 m for the estimated distance at 50% detection probability (D 50 ). Conclusion When few detections of multiple transmissions suffice to ascertain presence within a time bin, predicted range differs distinctly from the probability of detecting a single transmission within that time bin. We recommend the use of more rigorous range testing methodologies for acoustic telemetry applications where the assessment of detection range is an integral part of the study design, the data analysis and the interpretation of results.

Published
2022
Full Text
View/download PDF

45. Outcome of Down patients with repaired versus unrepaired atrioventricular septal defect

Author

Mathies Daene, Lore De Pauw, Pieter De Meester, Els Troost, Philip Moons, Marc Gewillig, Filip Rega, Alexander Van De Bruaene, and Werner Budts

Subjects
Down syndrome, Atrioventricular septal defect, Atrioventricular canal, Surgery, Eisenmenger syndrome, Outcome, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background and aims: Patients with Down Syndrome (DS) are frequently born with an atrioventricular septal defect (AVSD). Surgical repair of the defect aims to minimize mortality and morbidity. However, a surgical intervention, specifically in DS patients, is not without risk and a subgroup of patients underwent only conservative non-surgical treatment. Outcome data of these different approaches are scarce. The aim of this retrospective study was to compare the long-term outcome of DS patients with and without surgery for AVSD. Methods: DS patients registered with AVSD in the hospital's database from January 1980 till December 2020 were selected. Patient characteristics, peri-operative if appropriate, and follow-up data were obtained from the medical files. Results: In total, 72 unrepaired (36 male, 50%) and 134 repaired patients (61 male, 46%) were included. After a maximum of 60 years of follow-up, the all-cause mortality was 45.8% and 17.1%, respectively. Thirty-six percent and 13%, respectively, were labeled as non-cardiovascular death. Mean survival time for unrepaired AVSD was 40.7 years (95% CI 36.1–45.2) and for repaired AVSD 38.5 years (95% CI 35.3–41.6) (Log rank p = 0.465). However, the survival rate 35 years after birth was 62.1% for unrepaired patients versus 81.7% for repaired patients. Mortality rates were the highest the first months after surgical repair. Conclusions: The mean survival rate of Down patients, born with an AVSD, did not differ between repair or not. However, long-term survival rate was higher in patients who underwent surgical repair. Mortality was highest the first months after surgery.

Published
2023
Full Text
View/download PDF

47. Distribution and sources of macrolitter on the seafloor in Belgian fisheries areas

Author

David Vanavermaete, Katrien Verlé, Lisa I. Devriese, Karien De Cauwer, Coline De Schrijver, Els Torreele, Loes Vandecasteele, Milica Velimirovic, Kristof Tirez, Kris Hostens, and Bavo De Witte

Subjects
bottom trawl survey, dredge disposal, fishing activities, litter contamination, North Sea, offshore wind farms (OWFs), Science, General. Including nature conservation, geographical distribution, QH1-199.5
Abstract

Marine litter is recognized as a global environmental concern. Seafloor litter can provide important information to help assess the status of the marine ecosystem and is relatively easy to collect on a regular basis. The Belgian fisheries area covers different parts of the OSPAR Greater North Sea region and the Celtic Seas. In these regions, seafloor litter data were gathered by quantifying the litter items caught in the trawl net during two different fisheries surveys to investigate litter distribution on both regional and local scales. In the international beam trawl survey (BTS), covering essentially the OSPAR Greater North Sea and Celtic Seas, an average of 2.2 ± 0.05 items.ha-1 were caught with a median of 1.4 items.ha-1. In the environmental monitoring survey (EMS) only the Belgian part of the North Sea was covered and a smaller cod-end mesh size was used, resulting in 12.7 ± 1.7 litter items.ha-1 in the coastal zone (< 12 nm) and 2.8 ± 0.2 items.ha-1 in the more offshore zone (> 12 nm). In both surveys plastic items were predominant, representing up to 88% of the collected litter in the Belgian part of the North Sea. The impact of human activities at sea such as fisheries, sand extraction, wind farms and dredge disposal was investigated. A significant correlation was found between fishing activities and the amount of litter registered in the Belgian part of the North Sea, but not for the OSPAR Greater North Sea and Celtic Seas.

Published
2023
Full Text
View/download PDF

48. [Palliative sedation in a man with oral cancer; the Royal Dutch Medical Association guidelines not always sufficient]

Author

W L H Erwin, Smelt, Els T J, Wulffraat, Frans J G, Broekhoff, Ellen C, Dompeling, and J Hanneke, Vos-Westerman

Subjects
Male, Midazolam, Palliative Care, Carcinoma, Squamous Cell, Conscious Sedation, Humans, Hypnotics and Sedatives, Pain, Mouth Neoplasms, Middle Aged, Propofol
Abstract

Palliative sedation is an effective treatment option in patients with refractory symptoms in the last phase of life. In 2009 the Royal Dutch Medical Association (KNMG) published revised guidelines. The dosage of propofol recommended in these guidelines is, however, based on one single study.A 60-year-old patient with a history of psychiatric disease and alcohol abuse was admitted to the palliative care unit suffering from unbearable pain from a squamous carcinoma of the floor of the oral cavity. Adequate treatment of his symptoms was initially possible, but when his symptoms became refractory we initiated continual sedation. Adequate symptom control was only achieved when propofol was administered in a high dosage of 150 mg/h and levomepromazine administration was reinitiated.In our opinion the advised starting dose of propofol is too low, especially in comparison with sedation in regional anaesthesia described in the literature. Furthermore, we advocate that administration of drugs from step 2, midazolam and levomepromazine, is not discontinued when propofol sedation is commenced in step 3.

Published
2013

49. Results of Membrane-Activated Chelator Stroke Intervention randomized trial of DP-b99 in acute ischemic stroke

Author

Lees, K, Bornstein, N, Diener, H, Gorelick, P, Rosenberg, G, Shuaib, A, Fazekas, F, Ford, I, Mohr, J, Marshall, L, Geffen, P, Bibliowicz, A, Michel, D, Rotmensch, H, Schuckelt, R, Ding, D, Soeder, T, Gatterer, A, Gruber, F, Willeit, J, Weber, J, Moro, C, Silva, G, Rocha, M, Fabio, S, Buck, B, Tomek, A, Krajickova, D, Bauer, J, Ehler, E, Vaclavik, D, Dolezil, D, Sramek, M, Skoda, O, Sablot, D, Rouanet, F, Hosseini, H, Amarenco, P, Moulin, T, Ludolph, A, Hetzel, A, Kastrup, A, Griewing, B, Hobohm, C, Weimar, C, Reinhard, C, Nabavi, D, Schneider, D, Busch, E, Scherzinger, G, Glahn, J, Faiss, J, Klingelhofer, J, Wasser, K, Groeschel, K, Kohrmann, M, Maschke, M, Von Mering, M, Seidel, G, Goertler, M, Kaminski, R, Els, T, Walter, U, Limmroth, V, Csanyi, A, Valikovics, A, Panczel, G, Csiba, L, Szegedi, N, Horvath, S, Weller, B, Tanne, D, Dorodnicov, E, Leker, R, Lampl, Y, Micieli, G, Eleopra, R, Guidetti, D, Bottacchi, E, Agnelli, G, Comi, G, Bono, G, Melis, M, Stanzione, P, Di Lazzaro, V, Schreuder, T, Stepien, A, Czlonkowska, A, Kuczynska Zardzewialy, A, Stoinski, J, Jackowski, M, Brola, W, Fryze, W, Stelmasiak, Z, Cunha, L, Melo, T, Salgado, V, Cruz, V, Savic, M, Krastev, G, Vyletelka, J, Dvorak, M, Brozman, M, Nosal, V, Kok, A, Van Dyk, C, Bester, F, Roos, J, Gardiner, J, De Vries Basson, M, Davalos, A, de la Ossa, N, Rodríguez, C, Tejedor, A, E, Masjuan, J, Fábregas, J, Serena, J, Alvarez, J, Castillo, J, Pons, J, Vivancos, J, Arenillas, J, Segura, T, Lyrer, P, Vaishnav, A, Pineda, C, Veznedaroglu, E, Mallenbaum, S, Lees, Kr, Bornstein, N, Diener, Hc, Gorelick, Pb, Rosenberg, G, Shuaib, A, Comi, Giancarlo, and Macsi, Investigators

Subjects
Male, Time Factors, Medizin, Severity of Illness Index, law.invention, Randomized controlled trial, law, 80 and over, Acute treatment, Neuroprotection, Egtazic Acid, Acute ischemic stroke, Stroke, Chelating Agents, Aged, 80 and over, education.field_of_study, Middle Aged, Treatment Outcome, Administration, Administration, Intravenous, Female, Settore MED/26 - Neurologia, Drug, Intravenous, Cardiology and Cardiovascular Medicine, medicine.medical_specialty, Endpoint Determination, Population, Dose-Response Relationship, Double-Blind Method, Intervention (counseling), Internal medicine, Severity of illness, medicine, Humans, education, Aged, Advanced and Specialized Nursing, Dose-Response Relationship, Drug, business.industry, Therapeutic effect, medicine.disease, Surgery, Neurology (clinical), business
Abstract

Background and Purpose— DP-b99, a lipophilic moderate-affinity chelator of zinc, was postulated to improve recovery after acute ischemic stroke. We evaluated the safety and therapeutic effects of DP-b99 in patients with acute hemispheric ischemic stroke. Methods— The Membrane-Activated Chelator Stroke Intervention trial was a randomized, double-blind, placebo-controlled, multicenter, parallel-group trial of intravenous DP-b99 administered for 4 consecutive days (NCT00893867). Acute ischemic stroke patients within 9 hours of onset, but untreated by alteplase, with a baseline National Institutes of Health Stroke Scale score of 10 to 16, and evidence of language dysfunction, visual field defect, and neglect were eligible. The primary efficacy analysis compared distributions of functional status measured by modified Rankin score in the intent-to-treat population of patients with any post-treatment outcome, adjusted for initial severity. Functional and neurological recovery were secondary measures. Home time was an exploratory end point. Results— Enrollment terminated at n=446 after the planned interim analysis determined futility; follow-up continued. Final modified Rankin score distributions were equal between DP-b99 and placebo-treated groups ( P =0.10; P adj adjusted for baseline age and National Institutes of Health Stroke Scale=0.21). Fewer patients recovered to modified Rankin score ≤1 in the DP-b99–treated group (45/218; 20.6%) than after placebo (63/219; 28.8%) ( P =0.05; P adj =0.10). Similarly, fewer patients attained National Institutes of Health Stroke Scale ≤1 after DP-b99 (42/218; 19.3%) than placebo (56/219; 25.6%; P =0.10; P adj =0.26). Mortality was similar between DP-b99 and placebo intent-to-treat groups (36/218; 16.5% vs 33/219; 15.1%; P =0.68). Home time was unchanged by treatment (median 36 vs 36.5 days; P =0.25). Conclusions— Despite encouraging preclinical and phase II trial data, DP-b99 shows no evidence of efficacy in treating human ischemic stroke.

Published
2013

50. Robust distributed H-infinity control of electrical power systems

Author

Jokić, Andrej, Els, T. F. van der, and Weiland, Siep

Subjects
distributed control, optimal control, robust control, power systems
Abstract

We consider the problem of synthesizing an optimal robust distributed controller for real-time power balance control in large-scale electrical power systems. Various sufficient robust performance analysis results are summarized together with a computationally tractable distributed controller synthesis algorithm. The proposed synthesis algorithm is tested on a benchmark example of a multi-area power system. The closed loop performance with obtained robust distributed controller is compared with performance of the optimal centralized H-infinity controller.

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results