1. Disparities in the excess risk of mortality in the first wave of COVID-19: Cross sectional study of the English sentinel network
- Author
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Mark Joy, Maria Zambon, Gary Howsam, Brian D Nicholson, Jamie Lopez-Bernal, Julian Sherlock, Simon de Lusignan, Kevin E. Brown, Dylan McGagh, Cecilia Okusi, Gayatri Amirthalingam, Else Krajenbrink, Ruby S. M. Tsang, John H. H. Williams, FD Richard Hobbs, Rachel Byford, Gavin Dabrera, Filipa Ferreira, Mary Ramsay, Oluwafunmi Akinyemi, Mary Sinnathamby, Jason Oke, Harshana Liyanage, James P Sheppard, and Victoria Tzortziou Brown
- Subjects
0301 basic medicine ,Microbiology (medical) ,Male ,Multivariate analysis ,Coronavirus disease 2019 (COVID-19) ,Heart disease ,Cross-sectional study ,030106 microbiology ,Pneumonia, Viral ,Black People ,Comorbidity ,White People ,03 medical and health sciences ,Betacoronavirus ,0302 clinical medicine ,Sex Factors ,Risk Factors ,medicine ,Humans ,030212 general & internal medicine ,Pandemics ,Aged ,Family Characteristics ,business.industry ,SARS-CoV-2 ,Absolute risk reduction ,Age Factors ,COVID-19 ,Middle Aged ,medicine.disease ,Confidence interval ,Infectious Diseases ,Cross-Sectional Studies ,England ,Female ,business ,Coronavirus Infections ,Sentinel Surveillance ,Kidney disease ,Demography - Abstract
© 2020 The Authors Objectives: Few studies report contributors to the excess mortality in England during the first wave of coronavirus disease 2019 (COVID-19) infection. We report the absolute excess risk (AER) of mortality and excess mortality rate (EMR) from a nationally representative COVID-19 sentinel surveillance network including known COVID-19 risk factors in people aged 45 years and above. Methods: Pseudonymised, coded clinical data were uploaded from contributing primary care providers (N = 1,970,314, ≥45years). We calculated the AER in mortality by comparing mortality for weeks 2 to 20 this year with mortality data from the Office for National Statistics (ONS) from 2018 for the same weeks. We conducted univariate and multivariate analysis including preselected variables. We report AER and EMR, with 95% confidence intervals (95% CI). Results: The AER of mortality was 197.8/10,000 person years (95%CI:194.30–201.40). The EMR for male gender, compared with female, was 1.4 (95%CI:1.35–1.44, p
- Published
- 2020