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Your search keyword '"Elzeftawy, Mohamad A."' showing total 7 results
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7 results on '"Elzeftawy, Mohamad A."'

3. Once-weekly Insulin Icodec Versus Once-daily Long-acting Insulin for Type II Diabetes: A Meta-analysis of Randomized Controlled Trials.

Author

Abuelazm, Mohamed, Ibrahim, Ahmed A, Khlidj, Yehya, Badr, Amr, Amin, Ahmed Mazen, Elzeftawy, Mohamad A, Gowaily, Ibrahim, Elsaeidy, Ahmed Saad, and Abdelazeem, Basel

Subjects
TYPE 2 diabetes, RANDOMIZED controlled trials, INSULIN derivatives, INSULIN, GLYCOSYLATED hemoglobin
Abstract

Background Insulin icodec is a novel basal insulin analog with once-weekly subcutaneous administration. We aim to estimate the efficacy and safety of insulin icodec vs long-acting insulin (insulin glargine and degludec) in type II diabetic patients. Methods We conducted a systematic review and meta-analysis synthesizing randomized controlled trials (RCTs), which were retrieved by systematically searching PubMed, Web of Science, SCOPUS, and Cochrane through May 29, 2023. We used RevMan V. 5.4 to pool dichotomous data using risk ratio (RR) and continuous data using mean difference (MD) with a 95% confidence interval (CI). Our primary outcome was glycated hemoglobin (HbA1C) change. Results We included 7 RCTs with a total of 3183 patients. Insulin icodec was associated with significantly decreased HbA1C (MD: −0.15 with 95% CI [−0.24, −0.06], P =.002) and increased percentage of time with glucose in range (TIR) (MD: 4.06 with 95% CI [2.06, 6.06], P =.0001). However, insulin icodec was associated with increased body weight (MD: 0.57 with 95% CI [0.45, 0.70], P =.00001). Also, there was no difference regarding any serious adverse events (AEs) (RR: 0.96 with 95% CI [0.76, 1.20], P =.7) or AEs leading to withdrawal (RR: 1.54 with 95% CI [0.84, 2.82], P =.16). However, insulin icodec was associated with increased any AEs incidence (RR: 1.06 with 95% CI [1.01, 1.12], P =.02). Conclusion Insulin icodec was associated with decreased HbA1C, increased TIR, with similar hypoglycemic and serious AEs. However, it was also associated with increased body weight and the incidence of any AEs. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Analgesic Effect of Dexmedetomidine or Magnesium Sulphate Added to Bupivacaine in Interscalene Brachial Plexus Block During Shoulder Arthroscopy

Author

Ahmed S. Elgebaly Mona B. Fayad and Doaa A. Elzeftawy Mohamad A. El-Harty

Subjects
Bupivacaine, Shoulder surgery, business.industry, Interscalene brachial plexus block, medicine.medical_treatment, Sedation, Analgesic, law.invention, Randomized controlled trial, law, Anesthesia, medicine, Dexmedetomidine, medicine.symptom, business, medicine.drug, Brachial plexus block
Abstract

Background: Shoulder surgery is accompanied with sig-nificant post-operative pain. Interscalene block is one of regional techniques which is effective and safe to control this pain. Magnesium Sulphate (MgSO4) & dexmedetomidine as adjuvants to bupivacaine is expected to prolong the block with minimal undesirable systemic effects.Aim of Study: The aim of this work was to evaluate the post-operative analgesic effects of ultrasound guided intersca-lene brachial plexus block in elective shoulder surgeries under general anesthesia using either bupivacaine, bupivacaine-magnesium sulphate or bupivacaine-dexmedetomidine.Material and Methods: This double blind RCT was carried out on 45 patients of both sexes, 18-60y, ASA I or II and scheduled for elective arthroscopic shoulder surgeries under GA. US guided interscalene block with total volume 20ml was done to all patients who randomly allocated into 3 equal groups: Group I (control group): 0.25% bupivacaine 18ml, Group II (Mg group): 0.25% bupivacaine 18ml + 2ml 10% MgSO4 200mg and Group III (Dex group): 0.25% bupivacaine 18ml + 2ml dexmedetomidine (100m g). HR & MAP at baseline, skin incision, 30, 60, 90 & 120min after skin incision and at 2h, 4h, 6h & 8h post-operative, onset & duration of sensory block, (VAS & sedation score) at 2, 4, 6, 8 & 12hrs post-operative, onset of 1st and total dose of meperidine and complications were measured.Results: Our results showed no significant difference as regard to age, sex, ASA, duration & type of surgery, sedation score but there was significant decrease in HR, MAP, VAS, onset of sensory block & 1st analgesic requirements, total dose of rescue analgesic and prolongation in sensory block in Mg group & Dex group as compared to control group & also Dex group was superior to Mg group.Conclusion: Dexmedetomidine 100μg was better than MgSO4 200mg when they added to bupivacaine 0.25% in US guided interscalene brachial plexus block as evidenced by prolongation of sensory block, improved quality of post-operative analgesia, decreased requirements of rescue analge-sics and providing desirable sedation without side effects.

Published
2019

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