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29 results on '"Elzenga, Nynke J."'

7. Pulmonary ductal coarctation and left pulmonary artery interruption; pathology and role of neural crest and second heart field during development

Author

Gittenberger-de Groot, Adriana C., primary, Peterson, Joshua C., additional, Wisse, Lambertus J., additional, Roest, Arno A. W., additional, Poelmann, Robert E., additional, Bökenkamp, Regina, additional, Elzenga, Nynke J., additional, Hazekamp, Mark, additional, Bartelings, Margot M., additional, Jongbloed, Monique R. M., additional, and DeRuiter, Marco C., additional

Published
2020
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20. Comparative values of the precordial and transesophageal approaches in the echocardiographic evaluation of atrial baffle function after an atrial correction procedure

Author

Kaulitz, Renate, primary, Stümper, Oliver F.W., additional, Geuskens, Rene, additional, Sreeram, Narayanswami, additional, Elzenga, Nynke J., additional, Chan, Chen K., additional, Burns, Janet E., additional, Godman, Michael J., additional, Hess, John, additional, and Sutherland, George R., additional

Published
1990
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25. Aspirin versusIndomethacin Treatment of Patent Ductus Arteriosus in Preterm Infants with Respiratory Distress Syndrome

Author

OVERMEIRE, BART VAN, BRUS, FRANK, ACKER, KAREL J. VAN, AUWERA, JEAN C. VAN DER, SCHASFOORT, MIEK, ELZENGA, NYNKE J., and OKKEN, ALBERT

Abstract

Indomethacin (Indo) is commonly used for treatment of patent ductus arteriosus (PDA) but has renal failure as a main side effect. Aspirin (ASA) is an alternative, but there are no controlled trials on its efficacy. We randomly assigned 75 premature infants suffering from respiratory distress syndrome (RDS) (mean gestational age: 29.6 ± 2.5 wk, mean birth weight: 1295 ± 464 g) (±SD) and on artificial ventilation at the start of the study (mean: 3.4 d of life), to either Indo (3 x 0.2 mg/kg/12 h) or ASA (4 X 15 mg/kg/6 h). PDA and degree of shunting were evaluated by echocardio-Doppler; side effects were carefully recorded. PDA closed in 35/38 patients from the Indo group (92) and in 16/37 patients from the ASA group (43) (p< 0.0001). Nineteen patients needed further treatment with Indo or surgery (17 in the ASA group and 2 in the Indo group). The only side effect observed was a decrease of uresis in the Indo group during 4 d post treatment (p< 0.01). Closing of PDA was positively correlated with gestational age, but not with time of starting Indo/ASA or grade of shunting. We conclude that ASA is not as effective in closing PDA as Indo, but has no adverse effect on uresis.

Published
1995

29. Echocardiography in pediatric pulmonary arterial hypertension: early study on assessing disease severity and predicting outcome.

Author

Ploegstra MJ, Roofthooft MT, Douwes JM, Bartelds B, Elzenga NJ, van de Weerd D, Hillege HL, and Berger RM

Subjects
Adolescent, Age Factors, Atrial Function, Right, Atrial Pressure, Biomarkers blood, Child, Child, Preschool, Disease Progression, Familial Primary Pulmonary Hypertension mortality, Familial Primary Pulmonary Hypertension physiopathology, Familial Primary Pulmonary Hypertension therapy, Female, Heart Defects, Congenital complications, Heart Ventricles diagnostic imaging, Heart Ventricles physiopathology, Humans, Hypertension, Pulmonary etiology, Hypertension, Pulmonary mortality, Hypertension, Pulmonary physiopathology, Hypertension, Pulmonary therapy, Infant, Kaplan-Meier Estimate, Lung Transplantation, Male, Natriuretic Peptide, Brain blood, Netherlands, Peptide Fragments blood, Predictive Value of Tests, Prognosis, Proportional Hazards Models, Prospective Studies, Risk Factors, Severity of Illness Index, Stroke Volume, Time Factors, Tricuspid Valve diagnostic imaging, Tricuspid Valve physiopathology, Ventricular Function, Left, Ventricular Function, Right, Young Adult, Echocardiography, Doppler, Familial Primary Pulmonary Hypertension diagnostic imaging, Hypertension, Pulmonary diagnostic imaging
Abstract

Background: The value of echocardiography in assessing disease severity and predicting outcome in pediatric pulmonary arterial hypertension (PAH) is insufficiently defined. The aim of this study was to describe correlations between echocardiography and disease severity and outcome in pediatric PAH., Methods and Results: Forty-three consecutive children (median age, 8.0 years; range, 0.4-21.5) with idiopathic/hereditary PAH (n=25) or PAH associated with congenital heart disease (n=18) were enrolled in a prospective single-center observational study. Anatomic and right ventricular-functional variables were obtained by two-dimensional echocardiography and Doppler-echocardiography at presentation and at standardized follow-up and were correlated with measures of disease severity (World Health Organization functional class [WHO-FC], N-terminal-pro-B-type natriuretic peptide, hemodynamics) and lung-transplantation-free survival. Right atrial and right ventricular dimensions correlated with WHO-FC and hemodynamics (P<0.05), whereas left ventricular dimensions correlated with hemodynamics and survival (P<0.05). Right-to-left ventricular dimension ratiocorrelated with WHO-FC, hemodynamics and survival (P<0.05). Right ventricular ejection time correlated with hemodynamics and survival (P<0.05) and tended to correlate with WHO-FC (P=0.071). Tricuspid annular plane systolic excursion correlated with WHO-FC, mean right atrial pressure and survival (P<0.05)., Conclusions: This early descriptive study shows that echocardiographic chararacteristics of both the right and the left heart correlate with disease severity and outcome in pediatric PAH, both at presentation and during the course of the disease. The preliminary data from this study support the potential value of echocardiography as a tool in guiding management in children with PAH., (© 2014 American Heart Association, Inc.)

Published
2014
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