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الملخص: أهداف البحث: تهدف الدراسة إلى مقارنة رغبة الحالات المتعافية من كوفيد-١٩ والمتطوعين الأصحاء للمشاركة في التجربة السريرية للقاح كوفيد-١٩. طرق البحث: أُجريت الدراسة على السكان السعوديين خلال شهر سبتمبر ٢٠٢٠. وتم جمع البيانات من المشاركين المتعافين من كوفيد-١٩ ومن متطوعين أصحاء. النتائج: أظهرت النتائج أن ٤٢.٢٪ من الـحالات المتعافية (٣١٥) كانوا أكثر استعدادا للمشاركة في تجربة اللقاح من المتطوعين الأصحاء ٣٨.١٪ (٢٩٩). نسبة المشاركين الذين كانوا على استعداد للتبرع بالبلازما أعلى بكثير بين المشاركين المتعافين ٨٤.٢٪ (١٢٢) من المتطوعين الأصحاء ٧٦.٣٪ (٨٧). وكان أهم عامل مسؤول عن الرغبة في المشاركة هو الاعتقاد بأن اكتشاف اللقاح من شأنه أن يساعد علميا. وبالمقارنة، كانت الأسباب الهامة وراء عدم الرغبة في المشاركة هي خطر التعرض للقاح غير مثبت والشعور بمعاملة الشخص كعينة تجريبية. الاستنتاجات: لا يشير فرق استعداد المشاركين تجاه تجربة لقاح كوفيد-١٩ على أن المتعافين هم على استعداد لتلقي المخـاطر المعرضة من اللقاح التجريبي السريي غير المثبت ولا يشير إلى علم الأصحاء الجيد بالقرارات المتعلقة بالمخاطر. ومع ذلك، هناك بعض العوامل التي تؤثر بشكل كبير على اتخاذ القرار عند المشاركة في الأبحاث السريرية. وبالتالي، يجب عدم استخدام نتائج هذه الدراسة بتحيز أثناء تعيين الأفراد في تجربة لقاح كوفيد-١٩. Abstract: Objectives: This study examines the Saudi Arabian population's willingness to participate in clinical trials for the coronavirus disease 2019 (COVID-19) vaccine, comparing recovered cases' willingness with that of healthy volunteers. Methods: A case–control study was conducted on the Saudi Arabian population during September 2020. The data were collected from recovered COVID-19 participants as the case group, and healthy volunteers as the control group. Results: The data showed that 42.2% (n = 315) of recovered COVID-19 cases were more willing to participate in the COVID-19 vaccine trial than healthy volunteers (299; 38.1%) with a p

To compare the effectiveness of peer-assisted learning (PAL) and expert-assisted learning (EAL) in terms of knowledge gain in virtual chest x-ray (CXR) interpretations. The secondary objective was to assess students' satisfaction levels between both groups.In this randomized controlled trial, second-year medical students who met the inclusion criteria were randomly assigned to the PAL and EAL groups. The study was carried out from December 2020 to February 2021 at Umm Al-Qura University, Makkah, Saudi Arabia. The primary endpoint was the difference in the students' scores, which were determined by an independent reviewer. The secondary endpoint was students' satisfaction levels.A total of 166 second year medical students were included. The standard deviation and mean age of the population were 19.73±0.66 (males: 79 [47.6%]; females: 87 [52.4%]). Participants were allocated equally into two groups (83 in each group). Student scores did not differ significantly between the two groups (Peer-assisted learning has equivalent efficacy compared to EAL in a virtual setting. The Students in the PAL group had higher level of satisfaction.

e18797 Background: Patients with cancer are vulnerable population that suffered during the COVID-19 pandemic from SARS-CoV-2 infection and from the pandemic’s impact on healthcare systems. We are presenting the findings of MENA Registry for COVID-19 and Cancer (MRCC) regarding the SARS-CoV-2 infection presentation, diagnosis, treatment, complications, and outcomes. Methods: MRCC was adapted from ASCO COVID-19 Registry and included patients with SARS-CoV-2 infection and underlying cancer diagnosis including a newly diagnosed cancer in the work-up phase or patients with active cancer receiving cancer therapy or supportive care, or within first year of adjuvant chemotherapy or after one year of curative therapy and receiving hormonal therapy. Registry included data on patients from 12 centers in eight countries in the MENA region, namely: Saudi Arabia, Jordan, Lebanon, Turkey, Egypt, Algeria, United Arab Emirates, and Morocco. The data included patient and disease characteristics, COVID-19 presentation, management, and outcomes. The follow up is differential as data get captured at different points of disease trajectory for each patient which may not reflect the final outcome. Results: Data on 1345 patients were captured in the study by December 7, 2021. Median age was 57.1 years (18-98), whereas 56.1% were females. The median follow-up was 98.5 days (0-554). The most common COVID-19 symptoms was fever (50.3%) and 26.8% of patients were asymptomatic. Out of the 959 patients with complete data on hospitalization, 554 (57.8%) were hospitalized and 126 of them (22.7%) were admitted to intensive care unit (ICU). The majority of hospitalized patients (60%) had respiratory complications and 13.9% had sepsis and 8.5% suffered acute renal injury. As shown in Table, more than quarter of the patients died with 47% of death from COVID-19 or related complication and 60.6% died at home. More than half of the patients were fully recovered from infection. Conclusions: Although more than half of the patients recovered form COVID-19 and more are expected to recover with a longer follow up, the death toll and complications remain high in this patient population. Future analysis of the impact of vaccination and better disease management as well as the impact of newer variants would provide a useful insight on managing this vulnerable population.[Table: see text]