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A novel magnetoelectric (ME) antenna is fabricated to be integrated to the on-chip energy harvesting circuit for brain-computer interface applications. The proposed ME antenna resonates at the frequency of 2.57 GHz while providing a bandwidth of 3.37 MHz. The proposed rectangular ME antenna wireless power transfer efficiency is 0.304 %, which is considerably higher than that of micro-coils.Clinical Relevance- This provides a suitable energy harvesting efficiency for wirelessly powering up the brain implant devices.

Introduction: Novel sensors were developed to detect exhaled volatile organic compounds to aid in the diagnosis of mild cognitive impairment associated with early stage Alzheimer's disease (AD). The sensors were sensitive to a rat model that combined the human apolipoprotein E (APOE)4 gene with aging and the Western diet., Methods: Gas sensors fabricated from molecularly imprinted polymer-graphene were engineered to react with alkanes and small fatty acids associated with lipid peroxidation. With a detection sensitivity in parts per trillion the sensors were tested against the breath of wild-type and APOE4 male rats. Resting state BOLD functional connectivity was used to assess hippocampal function., Results: Only APOE4 rats, and not wild-type controls, tested positive to several small hydrocarbons and presented with reduced functional coupling in hippocampal circuitry., Discussion: These results are proof-of-concept toward the development of sensors that can be used as breath detectors in the diagnosis, prognosis, and treatment of presymptomatic AD., Competing Interests: CFF has a financial interest in Animal Imaging Research, the company that manufactures the rat imaging system. PK has a financial interest in Ekam Solutions, the company that developed the rat atlas and analytical tools., (© 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.)