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1. Extraocular cutaneous sebaceous carcinoma in a patient with Muir-Torre syndrome: special emphasis on histologic and dermoscopic features

Author

Francesco Savoia, Matelda Medri, Davide Melandri, Lucia Domeniconi, Emilia Crisanti, Andrea Sechi, and Ignazio Stanganelli

Subjects
Cutaneous sebaceous carcinoma, Muir-Torre syndrome, hereditary nonpolyposis colorectal cancer syndrome, dermoscopy, Dermatology, RL1-803
Abstract

Cutaneous sebaceous carcinoma can be classified into periocular and extraocular and can occur as part of Muir Torre syndrome. It is usually a pink-red or yellow solitary nodule, mainly located in the head and neck region. According to the Literature, dermoscopy is characterized in most cases by yellow color, polymorphic vessels and ulceration. We performed a review of the Literature and we found 14 papers describing the dermoscopic features of 33 sebaceous carcinomas, to which we added a case that we have recently observed. Compared to the data of the Literature and in particular to the latest published reviews, we found that milky-red areas are frequently observed in CSC (47% of the cases) and can be added to the main dermoscopic features for the diagnosis. Histology showed, in our case, some features that were consistent with a cutaneous sebaceous carcinoma with a secretory pattern, and other features that were instead consistent with a non-secretory pattern. This was probably due to the fact that the lesion we observed was a moderately differentiated and not well-differentiated cutaneous sebaceous carcinoma. The presence of a cutaneous sebaceous carcinoma should always alert the clinician on the possible association with Muir-Torre syndrome and immunohistochemistry for mismatch repair genes defects can help in the diagnostic pathway.

Published
2023
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3. The long history of a melanoma associated with a congenital large plaque type blue nevus with subcutaneous cellular nodules

Author

Francesco Savoia, Giuseppe Gaddoni, Giuseppe Re, and Emilia Crisanti

Subjects
blue nevus, melanoma, congenital, large plaque type blue nevus with subcutaneous cellular nodules, Dermatology, RL1-803
Abstract

The term large plaque type blue nevus with subcutaneous cellular nodules (LPTBN-SN) refers to a huge blue nevus, usually located on the trunk, that develops subcutaneous nodules many years after the lesion has appeared. The potential malignancy of an LPTBN-SN was only discovered in 2012. We report the case of a 56-year-old Caucasian man that developed a cutaneous melanoma on an LPTBN-SN of the trunk. The first diagnosis was made more than 10 years before his death due to melanoma metastasis. The case reported here highlights the malignant potential of an LPTBN-SN, the very long course even without treatment and the possible coexistence of benign, borderline or malignant subcutaneous nodules in the same LPTBN-SN. Patients with large congenital blue nevi should be advised on the potential oncologic transformation of these lesions, the importance of follow-ups should be emphasized and, whenever possible, a preventive complete surgical removal should be evaluated before subcutaneous nodules develop.

Published
2015
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4. An atypical pigmented lesion of the nose

Author

Francesco Savoia, Giuseppe Gaddoni, Vincenzo Albano, Vera Tengattini, Lorenza Ricci, Annalisa Patrizi, and Emilia Crisanti

Subjects
pigmented squamous cell carcinoma, dermoscopy, pigmented lesion, melanoma, cutaneous carcinoma, dermatoscopy, Dermatology, RL1-803
Published
2014
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6. Oral mucosal hyperpigmentation in a patient with a previous diagnosis of melanoma of the scalp

Author

Francesco Savoia, Michela Tabanelli, Emilia Crisanti, Annalisa Patrizi, Ambra Di Altobrando, Emi Dika, Di Altobrando A., Tabanelli M., Crisanti E., Dika E., Patrizi A., and Savoia F.

Subjects
medicine.medical_specialty, medicine.anatomical_structure, business.industry, Scalp, Melanoma, medicine, Dermatology, medicine.symptom, medicine.disease, business, Hyperpigmentation
Published
2020

8. Multiple acquired pigmented lesions in a patient affected by melanoma

Author

Francesco Savoia, Michela Tabanelli, Emilia Crisanti, Ignazio Stanganelli, Antonio Ascari Raccagni, and Domenico Piccolo

Subjects
Male, medicine.medical_specialty, Skin Neoplasms, Patient affected, business.industry, Melanoma, MEDLINE, Dermatology, Middle Aged, medicine.disease, medicine, Humans, business
Published
2018

9. An atypical pigmented lesion on the nose—Answer

Author

Giuseppe Gaddoni, Lorenza Ricci, Emilia Crisanti, Vera Tengattini, Francesco Savoia, Vincenzo Albano, Annalisa Patrizi, Francesco Savoia, Giuseppe Gaddoni, Vincenzo Albano, Vera Tengattini, Lorenza Ricci, Annalisa Patrizi, and Emilia Crisanti

Subjects
medicine.medical_specialty, business.industry, Quiz, Dermatology, atypical pigmented lesion, medicine.anatomical_structure, Atypical pigmented lesion, Oncology, RL1-803, Genetics, medicine, nose, business, Molecular Biology, Nose
Abstract

Below find the answer and discussion to the quiz by Savoia et al. presented in the previous issue of Dermatology Practical & Conceptual (http://dx.doi.org/10.5826/dpc.0401a12).

Published
2014
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10. The long history of a melanoma associated with a congenital large plaque type blue nevus with subcutaneous cellular nodules

Author

Giuseppe Gaddoni, Francesco Savoia, Giuseppe Re, and Emilia Crisanti

Subjects
Pathology, medicine.medical_specialty, business.industry, Melanoma, congenital, Observation, Dermatology, medicine.disease, Malignancy, Trunk, Metastasis, blue nevus, Lesion, Oncology, Subcutaneous nodule, RL1-803, Cutaneous melanoma, Genetics, medicine, melanoma, large plaque type blue nevus with subcutaneous cellular nodules, medicine.symptom, business, Molecular Biology, Blue nevus
Abstract

The term large plaque type blue nevus with subcutaneous cellular nodules (LPTBN-SN) refers to a huge blue nevus, usually located on the trunk, that develops subcutaneous nodules many years after the lesion has appeared. The potential malignancy of an LPTBN-SN was only discovered in 2012. We report the case of a 56-year-old Caucasian man that developed a cutaneous melanoma on an LPTBN-SN of the trunk. The first diagnosis was made more than 10 years before his death due to melanoma metastasis. The case reported here highlights the malignant potential of an LPTBN-SN, the very long course even without treatment and the possible coexistence of benign, borderline or malignant subcutaneous nodules in the same LPTBN-SN. Patients with large congenital blue nevi should be advised on the potential oncologic transformation of these lesions, the importance of follow-ups should be emphasized and, whenever possible, a preventive complete surgical removal should be evaluated before subcutaneous nodules develop.

Published
2015

11. Contents Vol. 64, 2003

Author

Steven J. O’Day, Emilia Crisanti, Massimo Di Maio, Peter K. Vogt, Manuela Pacyna-Gengelbach, Marija Gamulin, Giulio C. Spagnoli, Simona Messinese, S. Pyrhönen, Kurt Kletter, D.M. Katschinski, Tomotaka Kawayama, K.E. Rosenblatt, Tetsuya Yamamoto, Takashi Sugimura, R. Bendardaf, Chang Ok Suh, Keisuke Matsusaki, Takuji Okusaka, Y. Kishimoto, Daniele Turci, N. Malamos, Faraj Terro, Regina Deck, J. Laine, E. Karyda, Bert Hildebrandt, Takashi Fujishita, Genichi Nishimura, Cesare Gridelli, J. Tímár, Yuichi Oshita, K. Drumea, Ross E. Turner, W. Longo, Tsuyoshi Kimura, Rafael M. Nagler, Wataru Yasui, Tatsuhiko Kashii, Ofer Ben-Itzhak, Martha Hoffmann, Shuichi Okada, Hitoshi Tsuda, N. Haim, H. Lamlum, Monika Jermann, Koichi Shimizu, Hirofumi Nakayama, H. Kujari, Markus Raderer, Giuseppe D'Aiuto, Z. Orosz, H. Bailey, Sachio Fushida, Hejing Wang, M. Ben-Shachar, Anna Cappellini, Takashi Fukutomi, Ira Minkov, Jacques Hugon, Sandrine Robert, Frank Trimoreau, Johanna Skoglund, Yasuhiko Kitadai, Francesco Salvestrini, Maria Grazia Cantù, Shoko Oishi, Lars Meyer, Francesco Perrone, A. Kuten, Emanuela Rossi, Z. Voulgaris, Gunnar Arbman, Anna Emterling, Francesco Nuzzo, Peter D. Boasberg, Bernhard C. Pestalozzi, J. Hasegawa, R. Epelbaum, G. Shiota, Catherine Yardin, Michiya Matunami, Kazuaki Miyamoto, Kuniko Wakazono, John Carstensen, Tomislav Oresic, A. Ardavanis, Shoshana Ben-Eliezer, Hiroshi Funaki, Gerardo Amabile, Hedviga Kerner, Robert Šeparović, Luigi Terracciano, Alexander Becherer, Eleni Petridou, Y. Maeda, J. Finet, Hong Zhang, N. Miura, Takashi Tani, Massimo Loda, Toshimitsu Saisho, Antonio Juretić, W. Gillis, R. Ristamäki, K. Kalbakis, J.D.P. van Dijk, Hee Chul Park, M.E. Stein, Pierpaolo Correale, M Sabatino, Agnieszka Pietas, Roberto Petrioli, A.M. Westermann, S. Agelaki, Delia Marina Alexe, Michael Heberer, Daniele Pozzessere, Chigusa Morizane, Hisamichi Aizawa, A. Marumoto, Toshikazu Ushijima, Maurizio Marangolo, K. Malas, Oscar S. Breathnach, C.L. Tiggelaar, Antonio Rossi, Rumi Gohara, Takashi Fujimura, Naohide Oue, Itsuro Terada, Koichi Miwa, Gerardo Rosati, A. Bakhshandeh, Hiroshi Fukui, Yukiko Yagi, M. Gergye, Kiyoshi Asada, E. Jager, Kiyomi Taniyama, Masao Ichiki, Elke Schultz-Thater, Ulrich Jäger, Shunji Matsumura, Beth Tamar, Evagelos Spanos, Kyoo Ho Shin, Masato Kayahara, V. Georgoulias, Luigi Manzione, N. Udvarhelyi, Marinshine Gentler, P.Z. Vörde sive Vörding, Andreas Chott, Zbigniew Petrovich, Hideki Ueno, T. Bánfalvi, Diodoro Colarusso, Eric P. Winer, A. Knuth, Sofia Evertsson, J. Zidan, G. Landi, Yukihiro Tatemoto, Takeharu Koga, Ch. Kouroussis, Bozena Sarcevic, Eisaku Ueta, Iver Petersen, Zdenko Krajina, Y. Collan, Andrea de Matteis, Hong Ryull Pyo, V. Labonia, Y. Murawaki, François Labrousse, Hanno Riess, E. Gez, Panagiotis Koukoulomatis, S.O. Peters, Dimitrios Trichopoulos, Virginie Bellet, Teresa Di Palma, Tokio Osaki, Barbara Petit, A. Alexopoulos, T. Nakagawa, Ugo De Giorgi, Tomoko Kamimura, Jose Schneider, K. Gilde, Tim S. Kristedja, Isabelle Pommepuy, A. Neumann, Pat Ames, Tetsuo Ohta, Itasu Ninomiya, Susana M. Campos, G.J. Wiedemann, Guido Francini, Stefania Marsili, E. Tselepatiotis, Antonio Manganelli, Yuan Chen, Toru Rikimaru, Maureen Martin, D. Jager, Kelly Shinn, A. Sano, Bruce E. Johnson, Simone Petersen, H.I. Robins, Xiao-Feng Sun, and Shin-ichi Harada

Subjects
Cancer Research, Oncology, General Medicine
Published
2003
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12. Correlation between the Histopathology and the Epiluminescence Microscopy Features of Malignant Blue Nevus

Author

Lauro Bucchi, Emilia Crisanti, Giuseppe Lanzanova, Silvia Rafanelli, Orlando Silva, and Ignazio Stanganelli

Subjects
Pathology, medicine.medical_specialty, Skin Neoplasms, Dermatology, Biology, Melanin, Lesion, Nevus, Blue, Microscopy, medicine, Humans, Nevus, Blue nevus, Aged, Skin, Aged, 80 and over, Leg, Papillary dermis, General Medicine, Anatomy, medicine.disease, Microscopy, Fluorescence, Chronic Disease, Female, Surgery, Histopathology, medicine.symptom, Reticular Dermis
Abstract

background The validation of epiluminescence microscopy (ELM) for the diagnosis of pigmented skin lesions is conditional on the demonstration of consistent histologic correlates of the ELM patterns. The ELM characteristics of malignant blue nevus (MBN) have never been reported previously. objective To evaluate the histologic counterparts of the ELM features of a case of MBN. methods Comparison between the histologic characteristics observed in step-sections of the lesion and the structures observed in a digital ELM image. results On ELM, the lesion showed a diffuse whitish-blue veil, round black blotches, a collection of dark colored punctate spots, and fragmented bluish reticular-like formations in the periphery. At histologic examination, the black blotches and the spots appeared to correlate with areas of intense focal necrosis in the papillary and reticular dermis, and the reticular-like structures were demonstrated to correspond to the presence of free melanin and melanophages in the papillary dermis. conclusion In this case of MBN, blotches and spots seen on ELM correlated with intense necrosis in the papillary and reticular dermis, and reticular-like formations were the counterparts of free melanin and melanophages in the papillary dermis.

Published
1996
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13. Ovarian Sertoli-Leydig cell tumor, endometrioid-like yolk sac tumor, and Y-chromosomal material

Author

Daniele Turci, Ugo De Giorgi, Anna Cappellini, Maurizio Marangolo, Emilia Crisanti, and Maria Grazia Cantù

Subjects
Adult, Cancer Research, Pathology, medicine.medical_specialty, Ovary, Biology, Y chromosome, Sertoli-Leydig Cell Tumor, medicine, Humans, Yolk sac, Gynecology, Ovarian Neoplasms, Chromosomes, Human, Y, Endodermal Sinus Tumor, Cancer, Karyotype, General Medicine, medicine.disease, Pedigree, medicine.anatomical_structure, Oncology, Tumor progression, Female, Ovarian cancer
Abstract

Sertoli-Leydig cell tumors (SLCTs) are rare neoplasms, accounting for less than 0.2% of ovarian tumors. The endometrioid-like variant of yolk sac tumor (YST) is very rare, and the most extensive series reported only 8 cases. We present a case of ovarian SLCT with endometrioid-like YST in a patient with a 46,XX karyotype with Y-chromosomal material. A 26-year-old woman had undergone a right salpingo-oophorectomy for SLCT with endometrioid-like YST. Chromosomal analysis revealed a 46,XX karyotype with Y-chromosomal material insertion into chromosome 1. The patient’s father and sister, and 7 other paternal relatives (4 male and 3 female) presented the same chromosome variant without evidence of cancer. The YST component relapsed to the right side of the uterine wall and then metastasized to the peritoneum and liver, while SLCT was eradicated with primary surgery. Several chemotherapeutic regimens were totally ineffective to control tumor progression. She died of disease progression 54 months after the diagnosis. We adopted the policy of a close surveillance for ovarian neoplasms for the 22-year-old sister of the patient, who presented the same Y-chromosomal material in her karyotype. In very rare tumors, new methods, based on molecular and cytogenetic models, are requested to define recommended management.

Published
2003

14. Subject Index Vol. 64, 2003

Author

Tomoko Kamimura, Peter D. Boasberg, Johanna Skoglund, Ira Minkov, Isabelle Pommepuy, W. Gillis, Francesco Salvestrini, S. Agelaki, J. Tímár, Eleni Petridou, Agnieszka Pietas, A. Bakhshandeh, Y. Maeda, Hirofumi Nakayama, Hong Zhang, Sandrine Robert, Takeharu Koga, Shoshana Ben-Eliezer, K. Kalbakis, Manuela Pacyna-Gengelbach, Ofer Ben-Itzhak, Marinshine Gentler, Anna Emterling, Peter K. Vogt, Shunji Matsumura, Luigi Manzione, Anna Cappellini, Hitoshi Tsuda, Tomislav Oresic, Robert Šeparović, G. Shiota, Tomotaka Kawayama, H. Kujari, Gunnar Arbman, Rafael M. Nagler, Wataru Yasui, Bernhard C. Pestalozzi, Marija Gamulin, Rumi Gohara, N. Miura, Tsuyoshi Kimura, Daniele Turci, François Labrousse, Jacques Hugon, D.M. Katschinski, H. Lamlum, Koichi Shimizu, Tatsuhiko Kashii, Hanno Riess, Takashi Sugimura, Massimo Loda, Ch. Kouroussis, A. Ardavanis, K. Drumea, J. Hasegawa, W. Longo, Michael Heberer, Ross E. Turner, N. Udvarhelyi, Jose Schneider, Sachio Fushida, Emanuela Rossi, Z. Voulgaris, A. Marumoto, Panagiotis Koukoulomatis, John Carstensen, E. Gez, H. Bailey, Maureen Martin, M.E. Stein, S.O. Peters, Naohide Oue, R. Bendardaf, K. Gilde, Iver Petersen, Zdenko Krajina, Hong Ryull Pyo, V. Labonia, Giulio C. Spagnoli, Francesco Nuzzo, Kuniko Wakazono, Hideki Ueno, Keisuke Matsusaki, Takuji Okusaka, Takashi Fukutomi, Kelly Shinn, Yasuhiko Kitadai, Simona Messinese, Beth Tamar, Chang Ok Suh, C.L. Tiggelaar, R. Epelbaum, Itsuro Terada, Kazuaki Miyamoto, Gerardo Amabile, R. Ristamäki, Diodoro Colarusso, Hisamichi Aizawa, Frank Trimoreau, H.I. Robins, Koichi Miwa, Gerardo Rosati, J. Laine, Faraj Terro, Eric P. Winer, Maria Grazia Cantù, Shoko Oishi, E. Karyda, A. Kuten, Takashi Fujishita, A. Knuth, E. Jager, N. Malamos, Sofia Evertsson, J. Zidan, Xiao-Feng Sun, Hiroshi Fukui, S. Pyrhönen, Evagelos Spanos, Shin-ichi Harada, Dimitrios Trichopoulos, Hedviga Kerner, Martha Hoffmann, Bert Hildebrandt, Regina Deck, Kyoo Ho Shin, V. Georgoulias, Hee Chul Park, Hiroshi Funaki, J. Finet, Toshimitsu Saisho, Steven J. O'Day, N. Haim, Monika Jermann, Yukihiro Tatemoto, Shuichi Okada, Delia Marina Alexe, T. Bánfalvi, Daniele Pozzessere, A.M. Westermann, Takashi Tani, Ulrich Jäger, Roberto Petrioli, Genichi Nishimura, G.J. Wiedemann, M. Ben-Shachar, Zbigniew Petrovich, Francesco Perrone, Yukiko Yagi, Susana M. Campos, Simone Petersen, Bruce E. Johnson, Yuichi Oshita, Kiyoshi Asada, A. Alexopoulos, Giuseppe D'Aiuto, Emilia Crisanti, Z. Orosz, Masato Kayahara, Antonio Manganelli, A. Neumann, Toshikazu Ushijima, Oscar S. Breathnach, Massimo Di Maio, Virginie Bellet, Y. Kishimoto, Cesare Gridelli, Teresa Di Palma, Luigi Terracciano, Tim S. Kristedja, Ugo De Giorgi, Tetsuya Yamamoto, P.Z. Vörde sive Vörding, Markus Raderer, M. Gergye, Lars Meyer, Tokio Osaki, Toru Rikimaru, Catherine Yardin, Alexander Becherer, G. Landi, Bozena Sarcevic, Itasu Ninomiya, D. Jager, Eisaku Ueta, Andrea de Matteis, Guido Francini, Stefania Marsili, E. Tselepatiotis, Chigusa Morizane, K.E. Rosenblatt, Kurt Kletter, Pierpaolo Correale, Pat Ames, Yuan Chen, A. Sano, T. Nakagawa, Michiya Matunami, Tetsuo Ohta, Antonio Rossi, Maurizio Marangolo, K. Malas, Antonio Juretić, M Sabatino, Takashi Fujimura, Kiyomi Taniyama, Masao Ichiki, Barbara Petit, Elke Schultz-Thater, Andreas Chott, J. D. P. Van Dijk, Hejing Wang, Y. Collan, and Y. Murawaki

Subjects
Cancer Research, Index (economics), Oncology, Statistics, Subject (documents), General Medicine, Mathematics
Published
2003
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15. PRIMARY OVARIAN CARCINOID PRESENTING AS ACUTE ABDOMEN

Author

G. Fiorentini, Giorgio Papiani, Daniele Turci, Maurizio Marangolo, U. De Giorgi, and Emilia Crisanti

Subjects
medicine.medical_specialty, Oncology, business.industry, Acute abdomen, General surgery, medicine, Radiology, Nuclear Medicine and imaging, medicine.symptom, business
Published
2002
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