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The current theory of carcinogenesis for the deadliest of 'ovarian' cancers-high-grade serous carcinoma (HGSC)-holds that the malignancy develops first in the fallopian tube and spreads to the ovaries, peritoneum, and/or regional lymph nodes. This is based primarily on the observation of early forms of serous neoplasia (serous tubal intraepithelial lesions [STILs], and serous tubal intraepithelial carcinomas [STICS]) in the fimbria of women undergoing risk reduction surgery. However, these lesions are uncommon in the general population, confer a low risk (5%) of HGSC following their removal in at-risk women with germ-line BRCA1/2 mutations, and require 4 or more years to recur as intraperitoneal HGSC. These features suggest that isolated STILs and STICs behave as precursors, with uncertain cancer risk rather than carcinomas. Their evolution to HGSC within, or after, escape from the tube could proceed stepwise with multiple biologic events; however, it is unclear whether tubal or ovarian HGSCs encountered in the setting of advanced disease evolved in the same fashion. The latter scenario could also be explained by a 'catastrophic' model in which STICs suddenly develop with invasive and metastatic potential, overwhelming or obscuring the site of origin. Moreover, a similar model might explain the sudden emergence of HGSC in the peritoneal cavity following escape of precursor cells years before. Long-term follow-up data from opportunistic or prophylactic salpingectomy should shed light on where malignant transformation occurs, as well as the timeline from precursor to metastatic HGSC. © 2022 The Pathological Society of Great Britain and Ireland.

In a climate of reduced access to affordable and appropriate housing, tent cities have emerged as a unique solution to homelessness. Conducted with a semi-structured interview schedule, this qualitative study presents the findings of research conducted at Tent City, Victoria in 2016. Using snowball sampling, 12 residents of Tent City participated in research that revealed four themes for analysis: (1) push and pull motivations to join the encampment; (2) the role of services in resident’s lives; (3) residents’ experiences with the outside community; and (4) Tent City as a home community. Push factors included substance abuse, mental health problems, unemployment, family problems while pull factors included lack of affordable and appropriate housing, loss of housing, and personal issues. Residents’ experiences with services were generally negative with social/health services being considered inadequate, housing options overly restrictive and controlling. The outside community was considered hostile...