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4 results on '"Emily M. Lehmann"'

1. Deep brain stimulation for movement disorders

Author

Kelly L. Collins, Emily M. Lehmann, and Parag G. Patil

Subjects
Deep brain stimulation, Parkinson's disease, Tremor, Dystonia, Surgery, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Deep brain stimulation (DBS) is a widely employed therapeutic modality for the treatment of movement disorders. Full FDA approval or humanitarian device exemption has been made for Parkinson's disease, tremor, and dystonia. In this review, we describe the indications and selection criteria, target selection, and outcomes for each of these conditions. In addition, we describe the operative techniques utilized in DBS surgery and look forward to new developments in DBS on the horizon.

Published
2010
Full Text
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2. Tales of diversity: Genomic and morphological characteristics of forty-six Arthrobacter phages.

Author

Karen K Klyczek, J Alfred Bonilla, Deborah Jacobs-Sera, Tamarah L Adair, Patricia Afram, Katherine G Allen, Megan L Archambault, Rahat M Aziz, Filippa G Bagnasco, Sarah L Ball, Natalie A Barrett, Robert C Benjamin, Christopher J Blasi, Katherine Borst, Mary A Braun, Haley Broomell, Conner B Brown, Zachary S Brynell, Ashley B Bue, Sydney O Burke, William Casazza, Julia A Cautela, Kevin Chen, Nitish S Chimalakonda, Dylan Chudoff, Jade A Connor, Trevor S Cross, Kyra N Curtis, Jessica A Dahlke, Bethany M Deaton, Sarah J Degroote, Danielle M DeNigris, Katherine C DeRuff, Milan Dolan, David Dunbar, Marisa S Egan, Daniel R Evans, Abby K Fahnestock, Amal Farooq, Garrett Finn, Christopher R Fratus, Bobby L Gaffney, Rebecca A Garlena, Kelly E Garrigan, Bryan C Gibbon, Michael A Goedde, Carlos A Guerrero Bustamante, Melinda Harrison, Megan C Hartwell, Emily L Heckman, Jennifer Huang, Lee E Hughes, Kathryn M Hyduchak, Aswathi E Jacob, Machika Kaku, Allen W Karstens, Margaret A Kenna, Susheel Khetarpal, Rodney A King, Amanda L Kobokovich, Hannah Kolev, Sai A Konde, Elizabeth Kriese, Morgan E Lamey, Carter N Lantz, Jonathan S Lapin, Temiloluwa O Lawson, In Young Lee, Scott M Lee, Julia Y Lee-Soety, Emily M Lehmann, Shawn C London, A Javier Lopez, Kelly C Lynch, Catherine M Mageeney, Tetyana Martynyuk, Kevin J Mathew, Travis N Mavrich, Christopher M McDaniel, Hannah McDonald, C Joel McManus, Jessica E Medrano, Francis E Mele, Jennifer E Menninger, Sierra N Miller, Josephine E Minick, Courtney T Nabua, Caroline K Napoli, Martha Nkangabwa, Elizabeth A Oates, Cassandra T Ott, Sarah K Pellerino, William J Pinamont, Ross T Pirnie, Marie C Pizzorno, Emilee J Plautz, Welkin H Pope, Katelyn M Pruett, Gabbi Rickstrew, Patrick A Rimple, Claire A Rinehart, Kayla M Robinson, Victoria A Rose, Daniel A Russell, Amelia M Schick, Julia Schlossman, Victoria M Schneider, Chloe A Sells, Jeremy W Sieker, Morgan P Silva, Marissa M Silvi, Stephanie E Simon, Amanda K Staples, Isabelle L Steed, Emily L Stowe, Noah A Stueven, Porter T Swartz, Emma A Sweet, Abigail T Sweetman, Corrina Tender, Katrina Terry, Chrystal Thomas, Daniel S Thomas, Allison R Thompson, Lorianna Vanderveen, Rohan Varma, Hannah L Vaught, Quynh D Vo, Zachary T Vonberg, Vassie C Ware, Yasmene M Warrad, Kaitlyn E Wathen, Jonathan L Weinstein, Jacqueline F Wyper, Jakob R Yankauskas, Christine Zhang, and Graham F Hatfull

Subjects
Medicine, Science
Abstract

The vast bacteriophage population harbors an immense reservoir of genetic information. Almost 2000 phage genomes have been sequenced from phages infecting hosts in the phylum Actinobacteria, and analysis of these genomes reveals substantial diversity, pervasive mosaicism, and novel mechanisms for phage replication and lysogeny. Here, we describe the isolation and genomic characterization of 46 phages from environmental samples at various geographic locations in the U.S. infecting a single Arthrobacter sp. strain. These phages include representatives of all three virion morphologies, and Jasmine is the first sequenced podovirus of an actinobacterial host. The phages also span considerable sequence diversity, and can be grouped into 10 clusters according to their nucleotide diversity, and two singletons each with no close relatives. However, the clusters/singletons appear to be genomically well separated from each other, and relatively few genes are shared between clusters. Genome size varies from among the smallest of siphoviral phages (15,319 bp) to over 70 kbp, and G+C contents range from 45-68%, compared to 63.4% for the host genome. Although temperate phages are common among other actinobacterial hosts, these Arthrobacter phages are primarily lytic, and only the singleton Galaxy is likely temperate.

Published
2017
Full Text
View/download PDF

3. Tales of diversity: Genomic and morphological characteristics of forty-six Arthrobacter phages

Author

Filippa G. Bagnasco, Melinda Harrison, Garrett Finn, David Dunbar, Machika Kaku, Rahat M. Aziz, Rodney A. King, Marisa Egan, Nitish S. Chimalakonda, Hannah M. Kolev, Daniel R. Evans, Allen W. Karstens, Christopher M. McDaniel, Lee E. Hughes, Megan L. Archambault, Marie C. Pizzorno, Jennifer E. Menninger, Robert C. Benjamin, Emily M. Lehmann, Karen K. Klyczek, Jakob R. Yankauskas, Hannah McDonald, Amelia M. Schick, Josephine E. Minick, Deborah Jacobs-Sera, Jade Connor, Megan C. Hartwell, Kayla M. Robinson, Haley Broomell, Kaitlyn E. Wathen, Kelly C. Lynch, Julia Y. Lee-Soety, Victoria A. Rose, Emily L. Stowe, Vassie C. Ware, Daniel S. Thomas, Bobby L. Gaffney, Shawn C. London, Daniel A. Russell, Kathryn M. Hyduchak, Jonathan L. Weinstein, Yasmene M. Warrad, Christine Zhang, Zachary T. Vonberg, Sarah Ball, Lorianna Vanderveen, Christopher J. Blasi, Corrina Tender, Morgan P. Silva, Katelyn M. Pruett, Claire A. Rinehart, Trevor Cross, Allison R. Thompson, Jeremy W. Sieker, Carter N. Lantz, Carlos A. Guerrero Bustamante, Katherine Borst, Jessica A. Dahlke, William Casazza, Cassandra T. Ott, Sarah K. Pellerino, Kelly E. Garrigan, J. Alfred Bonilla, Zachary S. Brynell, Morgan E. Lamey, Aswathi E. Jacob, Kate Allen, Emma A. Sweet, Francis E. Mele, Sierra N. Miller, Dylan Chudoff, Ashley B. Bue, Julia Schlossman, Graham F. Hatfull, Margaret A. Kenna, Kevin Hong Chen, Conner B. Brown, Christopher R. Fratus, Quynh D. Vo, Martha Nkangabwa, Mary A. Braun, Sydney O. Burke, Natalie Barrett, Bryan C. Gibbon, Courtney T. Nabua, Catherine M. Mageeney, William J. Pinamont, Stephanie E. Simon, Porter T. Swartz, Milan Dolan, Rohan Varma, Temiloluwa O. Lawson, Ross T. Pirnie, Kevin J. Mathew, Caroline K. Napoli, Rebecca A. Garlena, Jessica E. Medrano, Bethany M. Deaton, Welkin H. Pope, Chrystal Thomas, Michael A. Goedde, Amal Farooq, Gabbi Rickstrew, Hannah L. Vaught, A. Javier Lopez, Noah A. Stueven, Amanda L. Kobokovich, Tamarah L. Adair, Elizabeth A. Oates, Jacqueline F. Wyper, Elizabeth Kriese, Victoria M. Schneider, Susheel K. Khetarpal, Emily L. Heckman, Abby K. Fahnestock, Emilee J. Plautz, Travis N. Mavrich, Amanda K. Staples, Jonathan S. Lapin, Danielle M. DeNigris, Katrina Terry, In Young Lee, Sai A. Konde, Chloe A. Sells, Jennifer Huang, Marissa M. Silvi, Tetyana Martynyuk, Katherine C. DeRuff, Isabelle L. Steed, Kyra N. Curtis, Sarah J. Degroote, Scott M. Lee, Patrick A. Rimple, C. Joel McManus, Abigail T. Sweetman, Julia A. Cautela, and Patricia Afram

Subjects
0301 basic medicine, viruses, lcsh:Medicine, Astronomical Sciences, Genome, Biochemistry, Nucleotide diversity, Bacteriophage, Database and Informatics Methods, Rhodococcus, Bacteriophages, lcsh:Science, Genetics, education.field_of_study, Viral Genomics, Multidisciplinary, biology, Genomics, Proteases, Genomic Databases, Celestial Objects, Enzymes, Actinobacteria, Viruses, Physical Sciences, Research Article, Population, Genome, Viral, Microbial Genomics, Research and Analysis Methods, Microbiology, 03 medical and health sciences, Lysogenic cycle, Virology, Arthrobacter, education, Genome size, Comparative genomics, Bacteria, lcsh:R, Organisms, Genetic Variation, Biology and Life Sciences, Computational Biology, Proteins, Comparative Genomics, biology.organism_classification, Genome Analysis, Galaxies, 030104 developmental biology, Biological Databases, Enzymology, lcsh:Q
Abstract

The vast bacteriophage population harbors an immense reservoir of genetic information. Almost 2000 phage genomes have been sequenced from phages infecting hosts in the phylum Actinobacteria, and analysis of these genomes reveals substantial diversity, pervasive mosaicism, and novel mechanisms for phage replication and lysogeny. Here, we describe the isolation and genomic characterization of 46 phages from environmental samples at various geographic locations in the U.S. infecting a single Arthrobacter sp. strain. These phages include representatives of all three virion morphologies, and Jasmine is the first sequenced podovirus of an actinobacterial host. The phages also span considerable sequence diversity, and can be grouped into 10 clusters according to their nucleotide diversity, and two singletons each with no close relatives. However, the clusters/singletons appear to be genomically well separated from each other, and relatively few genes are shared between clusters. Genome size varies from among the smallest of siphoviral phages (15,319 bp) to over 70 kbp, and G+C contents range from 45-68%, compared to 63.4% for the host genome. Although temperate phages are common among other actinobacterial hosts, these Arthrobacter phages are primarily lytic, and only the singleton Galaxy is likely temperate.

Published
2017

4. Deep brain stimulation for movement disorders

Author

Emily M. Lehmann, Parag G. Patil, and Kelly L. Collins

Subjects
Parkinson's disease, Movement disorders, Deep brain stimulation, medicine.medical_treatment, lcsh:RC321-571, Tremor, medicine, Animals, Humans, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, health care economics and organizations, Dystonia, Movement Disorders, business.industry, Humanitarian Device Exemption, Fda approval, medicine.disease, nervous system diseases, surgical procedures, operative, Neurology, Surgery, medicine.symptom, business, Neuroscience
Abstract

Deep brain stimulation (DBS) is a widely employed therapeutic modality for the treatment of movement disorders. Full FDA approval or humanitarian device exemption has been made for Parkinson's disease, tremor, and dystonia. In this review, we describe the indications and selection criteria, target selection, and outcomes for each of these conditions. In addition, we describe the operative techniques utilized in DBS surgery and look forward to new developments in DBS on the horizon.

Published
2010

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