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5 results on '"Emily P. Greenstein"'

3. Identifying Support Effects in Au-Catalyzed CO Oxidation

Author

Scott M. Tatro, Louisa Savereide, Zachary R. Mansley, Emily Cheng, Ryan J. Paull, Kenneth R. Poeppelmeier, Laurence D. Marks, Jianguo Wen, Justin M. Notestein, Emily P. Greenstein, and Abha Gosavi

Subjects
Materials science, General Chemistry, Electronic structure, Photochemistry, Catalysis
Published
2021
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4. New England Congenital Cardiology Association Bicuspid Aortopathy Registry (NECCA BAR): A regional preventive cardiovascular care collaboration

Author

Jonathan N. Flyer, Brett W. Goudie, Emily P. Greenstein, Olga H. Toro-Salazar, Klejda Nikolli, Lynn A. Sleeper, Christopher J. Clarke, Pip Hidestrand, Ruchika Karnik, Sharon E. O'Brien, Mark V. Zilberman, and Ronald V. Lacro

Subjects
Pediatrics, Perinatology and Child Health, Cardiology and Cardiovascular Medicine
Published
2022
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5. Decreased expression of pigment epithelium derived factor (PEDF), an inhibitor of angiogenesis, in placentas of unexplained stillbirths

Author

Susan E. Crawford, Jennifer A. Doll, Beth A. Plunkett, Mona Cornwell, Philip Fitchev, Susan E. Gerber, and Emily P. Greenstein

Subjects
Adult, Angiogenesis, Placenta, Vascular permeability, Angiogenesis Inhibitors, Gestational Age, Biology, Andrology, chemistry.chemical_compound, Endocrinology, PEDF, Pregnancy, medicine, Humans, Inducer, Nerve Growth Factors, Eye Proteins, reproductive and urinary physiology, Serpins, Microvascular Density, Stillbirth, medicine.disease, Vascular endothelial growth factor, medicine.anatomical_structure, chemistry, Immunology, Animal Science and Zoology, Female, Developmental Biology
Abstract

Normal placental vascular development depends upon the complex interactions between angiogenic inducers and inhibitors within the placenta. Alterations within the placental microenvironment can promote an imbalance in angiogenic mediators which may be associated with adverse perinatal outcomes. The purpose of this study was to investigate the placentas of infants with unexplained stillbirth as compared to live-born infants and to determine whether alterations in angiogenic inducer vascular endothelial growth factor (VEGF) or inhibitor pigment epithelium-derived factor (PEDF) are associated with altered angiogenesis, vascular remodeling and stillbirth. Placentas of 22 unexplained stillbirths and 44 age-matched live-born controls were scored for microvascular density (MVD), vasculopathy and microvascular permeability. A subset was scored for expression of angiogenic inducer VEGF and inhibitor pigment epithelium-derived factor. Stillborn placentas demonstrated higher MVD than controls (mean+SD: 116.6+/-46.3 v. 60.8+/-13.5, respectively, p0.001). Vasculopathy was present in 10/22 (45%) stillbirths compared to 0/44 (0%) controls (p0.001); increased vascular permeability was present in 15/22 (68%) cases and 5/44 (11%) controls (p0.001). PEDF expression was significantly lower in stillborn placentas (1.7+/-0.3) than live-born controls (3.6+/-0.8, p0.01) while VEGF expression was similar (3.3+/-0.7 v. 3.7+/-0.4, respectively, p0.05). In conclusion, we found that unexplained stillbirth is associated with loss of angiogenic inhibitor PEDF, vasculopathy and heightened angiogenesis in the placenta.

Published
2008

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