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1. Large-scale assessment of physical activity in a population using high-resolution hip-worn accelerometry: the German National Cohort (NAKO)

Author

Weber, Andrea, van Hees, Vincent T., Stein, Michael J., Gastell, Sylvia, Steindorf, Karen, Herbolsheimer, Florian, Ostrzinski, Stefan, Pischon, Tobias, Brandes, Mirko, Krist, Lilian, Marschollek, Michael, Greiser, Karin Halina, Nimptsch, Katharina, Brandes, Berit, Jochem, Carmen, Sedlmeier, Anja M., Berger, Klaus, Brenner, Hermann, Buck, Christoph, Castell, Stefanie, Dörr, Marcus, Emmel, Carina, Fischer, Beate, Flexeder, Claudia, Harth, Volker, Hebestreit, Antje, Heise, Jana-Kristin, Holleczek, Bernd, Keil, Thomas, Koch-Gallenkamp, Lena, Lieb, Wolfgang, Meinke-Franze, Claudia, Michels, Karin B., Mikolajczyk, Rafael, Kluttig, Alexander, Obi, Nadia, Peters, Annette, Schmidt, Börge, Schipf, Sabine, Schulze, Matthias B., Teismann, Henning, Waniek, Sabina, Willich, Stefan N., Leitzmann, Michael F., and Baurecht, Hansjörg

Published
2024
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2. Framework and baseline examination of the German National Cohort (NAKO)

Author

Peters, Annette, Peters, Annette, Greiser, Karin Halina, Göttlicher, Susanne, Ahrens, Wolfgang, Albrecht, Maren, Bamberg, Fabian, Bärnighausen, Till, Becher, Heiko, Berger, Klaus, Beule, Achim, Boeing, Heiner, Bohn, Barbara, Bohnert, Kerstin, Braun, Bettina, Brenner, Hermann, Bülow, Robin, Castell, Stefanie, Damms-Machado, Antje, Dörr, Marcus, Ebert, Nina, Ecker, Margit, Emmel, Carina, Fischer, Beate, Franzke, Claus-Werner, Gastell, Sylvia, Giani, Guido, Günther, Matthias, Günther, Kathrin, Günther, Klaus-Peter, Haerting, Johannes, Haug, Ulrike, Heid, Iris M., Heier, Margit, Heinemeyer, Diana, Hendel, Thomas, Herbolsheimer, Florian, Hirsch, Jochen, Hoffmann, Wolfgang, Holleczek, Bernd, Hölling, Heike, Hörlein, Andreas, Jöckel, Karl-Heinz, Kaaks, Rudolf, Karch, André, Karrasch, Stefan, Kartschmit, Nadja, Kauczor, Hans-Ulrich, Keil, Thomas, Kemmling, Yvonne, Klee, Bianca, Klüppelholz, Birgit, Kluttig, Alexander, Kofink, Lisa, Köttgen, Anna, Kraft, Daniel, Krause, Gérard, Kretz, Lisa, Krist, Lilian, Kühnisch, Jan, Kuß, Oliver, Legath, Nicole, Lehnich, Anna-Therese, Leitzmann, Michael, Lieb, Wolfgang, Linseisen, Jakob, Loeffler, Markus, Macdonald, Anke, Maier-Hein, Klaus H., Mangold, Nina, Meinke-Franze, Claudia, Meisinger, Christa, Melzer, Juliane, Mergarten, Björn, Michels, Karin B., Mikolajczyk, Rafael, Moebus, Susanne, Mueller, Ulrich, Nauck, Matthias, Niendorf, Thoralf, Nikolaou, Konstantin, Obi, Nadia, Ostrzinski, Stefan, Panreck, Leo, Pigeot, Iris, Pischon, Tobias, Pschibul-Thamm, Irene, Rathmann, Wolfgang, Reineke, Achim, Roloff, Stefanie, Rujescu, Dan, Rupf, Stefan, Sander, Oliver, Schikowski, Tamara, Schipf, Sabine, Schirmacher, Peter, Schlett, Christopher L., Schmidt, Börge, Schmidt, Georg, Schmidt, Martin, Schöne, Gina, Schulz, Holger, Schulze, Matthias B., Schweig, Alexandra, Sedlmeier, Anja M., Selder, Sonja, Six-Merker, Julia, Sowade, Ramona, Stang, Andreas, Stegle, Oliver, Steindorf, Karen, Stübs, Gunthard, Swart, Enno, Teismann, Henning, Thiele, Inke, Thierry, Sigrid, Ueffing, Marius, Völzke, Henry, Waniek, Sabina, Weber, Andrea, Werner, Nicole, Wichmann, H.-Erich, Willich, Stefan N., Wirkner, Kerstin, Wolf, Kathrin, Wolff, Robert, Zeeb, Hajo, Zinkhan, Melanie, and Zschocke, Johannes

Published
2022
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3. A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

Author

Ramdas, Shweta, Judd, Jonathan, Graham, Sarah E., Kanoni, Stavroula, Wang, Yuxuan, Surakka, Ida, Wenz, Brandon, Clarke, Shoa L., Chesi, Alessandra, Wells, Andrew, Bhatti, Konain Fatima, Vedantam, Sailaja, Winkler, Thomas W., Locke, Adam E., Marouli, Eirini, Zajac, Greg J.M., Wu, Kuan-Han H., Ntalla, Ioanna, Hui, Qin, Klarin, Derek, Hilliard, Austin T., Wang, Zeyuan, Xue, Chao, Thorleifsson, Gudmar, Helgadottir, Anna, Gudbjartsson, Daniel F., Holm, Hilma, Olafsson, Isleifur, Hwang, Mi Yeong, Han, Sohee, Akiyama, Masato, Sakaue, Saori, Terao, Chikashi, Kanai, Masahiro, Zhou, Wei, Brumpton, Ben M., Rasheed, Humaira, Havulinna, Aki S., Veturi, Yogasudha, Pacheco, Jennifer Allen, Rosenthal, Elisabeth A., Lingren, Todd, Feng, QiPing, Kullo, Iftikhar J., Narita, Akira, Takayama, Jun, Martin, Hilary C., Hunt, Karen A., Trivedi, Bhavi, Haessler, Jeffrey, Giulianini, Franco, Bradford, Yuki, Miller, Jason E., Campbell, Archie, Lin, Kuang, Millwood, Iona Y., Rasheed, Asif, Hindy, George, Faul, Jessica D., Zhao, Wei, Weir, David R., Turman, Constance, Huang, Hongyan, Graff, Mariaelisa, Choudhury, Ananyo, Sengupta, Dhriti, Mahajan, Anubha, Brown, Michael R., Zhang, Weihua, Yu, Ketian, Schmidt, Ellen M., Pandit, Anita, Gustafsson, Stefan, Yin, Xianyong, Luan, Jian’an, Zhao, Jing-Hua, Matsuda, Fumihiko, Jang, Hye-Mi, Yoon, Kyungheon, Medina-Gomez, Carolina, Pitsillides, Achilleas, Hottenga, Jouke Jan, Wood, Andrew R., Ji, Yingji, Gao, Zishan, Haworth, Simon, Mitchell, Ruth E., Chai, Jin Fang, Aadahl, Mette, Bjerregaard, Anne A., Yao, Jie, Manichaikul, Ani, Lee, Wen-Jane, Hsiung, Chao Agnes, Warren, Helen R., Ramirez, Julia, Bork-Jensen, Jette, Kårhus, Line L., Goel, Anuj, Sabater-Lleal, Maria, Noordam, Raymond, Mauro, Pala, Matteo, Floris, McDaid, Aaron F., Marques-Vidal, Pedro, Wielscher, Matthias, Trompet, Stella, Sattar, Naveed, Møllehave, Line T., Munz, Matthias, Zeng, Lingyao, Huang, Jianfeng, Yang, Bin, Poveda, Alaitz, Kurbasic, Azra, Schönherr, Sebastian, Forer, Lukas, Scholz, Markus, Galesloot, Tessel E., Bradfield, Jonathan P., Ruotsalainen, Sanni E., Daw, E. Warwick, Zmuda, Joseph M., Mitchell, Jonathan S., Fuchsberger, Christian, Christensen, Henry, Brody, Jennifer A., Le, Phuong, Feitosa, Mary F., Wojczynski, Mary K., Hemerich, Daiane, Preuss, Michael, Mangino, Massimo, Christofidou, Paraskevi, Verweij, Niek, Benjamins, Jan W., Engmann, Jorgen, Noah, Tsao L., Verma, Anurag, Slieker, Roderick C., Lo, Ken Sin, Zilhao, Nuno R., Kleber, Marcus E., Delgado, Graciela E., Huo, Shaofeng, Ikeda, Daisuke D., Iha, Hiroyuki, Yang, Jian, Liu, Jun, Demirkan, Ayşe, Leonard, Hampton L., Marten, Jonathan, Emmel, Carina, Schmidt, Börge, Smyth, Laura J., Cañadas-Garre, Marisa, Wang, Chaolong, Nakatochi, Masahiro, Wong, Andrew, Hutri-Kähönen, Nina, Sim, Xueling, Xia, Rui, Huerta-Chagoya, Alicia, Fernandez-Lopez, Juan Carlos, Lyssenko, Valeriya, Nongmaithem, Suraj S., Sankareswaran, Alagu, Irvin, Marguerite R., Oldmeadow, Christopher, Kim, Han-Na, Ryu, Seungho, Timmers, Paul R.H.J., Arbeeva, Liubov, Dorajoo, Rajkumar, Lange, Leslie A., Prasad, Gauri, Lorés-Motta, Laura, Pauper, Marc, Long, Jirong, Li, Xiaohui, Theusch, Elizabeth, Takeuchi, Fumihiko, Spracklen, Cassandra N., Loukola, Anu, Bollepalli, Sailalitha, Warner, Sophie C., Wang, Ya Xing, Wei, Wen B., Nutile, Teresa, Ruggiero, Daniela, Sung, Yun Ju, Chen, Shufeng, Liu, Fangchao, Yang, Jingyun, Kentistou, Katherine A., Banas, Bernhard, Morgan, Anna, Meidtner, Karina, Bielak, Lawrence F., Smith, Jennifer A., Hebbar, Prashantha, Farmaki, Aliki-Eleni, Hofer, Edith, Lin, Maoxuan, Concas, Maria Pina, Vaccargiu, Simona, van der Most, Peter J., Pitkänen, Niina, Cade, Brian E., van der Laan, Sander W., Chitrala, Kumaraswamy Naidu, Weiss, Stefan, Bentley, Amy R., Doumatey, Ayo P., Adeyemo, Adebowale A., Lee, Jong Young, Petersen, Eva R.B., Nielsen, Aneta A., Choi, Hyeok Sun, Nethander, Maria, Freitag-Wolf, Sandra, Southam, Lorraine, Rayner, Nigel W., Wang, Carol A., Lin, Shih-Yi, Wang, Jun-Sing, Couture, Christian, Lyytikäinen, Leo-Pekka, Nikus, Kjell, Cuellar-Partida, Gabriel, Vestergaard, Henrik, Hidalgo, Bertha, Giannakopoulou, Olga, Cai, Qiuyin, Obura, Morgan O., van Setten, Jessica, He, Karen Y., Tang, Hua, Terzikhan, Natalie, Shin, Jae Hun, Jackson, Rebecca D., Reiner, Alexander P., Martin, Lisa Warsinger, Chen, Zhengming, Li, Liming, Kawaguchi, Takahisa, Thiery, Joachim, Bis, Joshua C., Launer, Lenore J., Li, Huaixing, Nalls, Mike A., Raitakari, Olli T., Ichihara, Sahoko, Wild, Sarah H., Nelson, Christopher P., Campbell, Harry, Jäger, Susanne, Nabika, Toru, Al-Mulla, Fahd, Niinikoski, Harri, Braund, Peter S., Kolcic, Ivana, Kovacs, Peter, Giardoglou, Tota, Katsuya, Tomohiro, de Kleijn, Dominique, de Borst, Gert J., Kim, Eung Kweon, Adams, Hieab H.H., Ikram, M. Arfan, Zhu, Xiaofeng, Asselbergs, Folkert W., Kraaijeveld, Adriaan O., Beulens, Joline W.J., Shu, Xiao-Ou, Rallidis, Loukianos S., Pedersen, Oluf, Hansen, Torben, Mitchell, Paul, Hewitt, Alex W., Kähönen, Mika, Pérusse, Louis, Bouchard, Claude, Tönjes, Anke, Ida Chen, Yii-Der, Pennell, Craig E., Mori, Trevor A., Lieb, Wolfgang, Franke, Andre, Ohlsson, Claes, Mellström, Dan, Cho, Yoon Shin, Lee, Hyejin, Yuan, Jian-Min, Koh, Woon-Puay, Rhee, Sang Youl, Woo, Jeong-Taek, Heid, Iris M., Stark, Klaus J., Zimmermann, Martina E., Völzke, Henry, Homuth, Georg, Evans, Michele K., Zonderman, Alan B., Polasek, Ozren, Pasterkamp, Gerard, Hoefer, Imo E., Redline, Susan, Pahkala, Katja, Oldehinkel, Albertine J., Snieder, Harold, Biino, Ginevra, Schmidt, Reinhold, Schmidt, Helena, Bandinelli, Stefania, Dedoussis, George, Thanaraj, Thangavel Alphonse, Peyser, Patricia A., Kato, Norihiro, Schulze, Matthias B., Girotto, Giorgia, Böger, Carsten A., Jung, Bettina, Joshi, Peter K., Bennett, David A., De Jager, Philip L., Lu, Xiangfeng, Mamakou, Vasiliki, Brown, Morris, Caulfield, Mark J., Munroe, Patricia B., Guo, Xiuqing, Ciullo, Marina, Jonas, Jost B., Samani, Nilesh J., Kaprio, Jaakko, Pajukanta, Päivi, Tusié-Luna, Teresa, Aguilar-Salinas, Carlos A., Adair, Linda S., Bechayda, Sonny Augustin, de Silva, H. Janaka, Wickremasinghe, Ananda R., Krauss, Ronald M., Wu, Jer-Yuarn, Zheng, Wei, den Hollander, Anneke I., Bharadwaj, Dwaipayan, Correa, Adolfo, Wilson, James G., Lind, Lars, Heng, Chew-Kiat, Nelson, Amanda E., Golightly, Yvonne M., Wilson, James F., Penninx, Brenda, Kim, Hyung-Lae, Attia, John, Scott, Rodney J., Rao, D.C., Arnett, Donna K., Walker, Mark, Scott, Laura J., Koistinen, Heikki A., Chandak, Giriraj R., Mercader, Josep M., Villalpando, Clicerio Gonzalez, Orozco, Lorena, Fornage, Myriam, Tai, E. Shyong, van Dam, Rob M., Lehtimäki, Terho, Chaturvedi, Nish, Yokota, Mitsuhiro, Liu, Jianjun, Reilly, Dermot F., McKnight, Amy Jayne, Kee, Frank, Jöckel, Karl-Heinz, McCarthy, Mark I., Palmer, Colin N.A., Vitart, Veronique, Hayward, Caroline, Simonsick, Eleanor, van Duijn, Cornelia M., Jin, Zi-Bing, Lu, Fan, Hishigaki, Haretsugu, Lin, Xu, März, Winfried, Gudnason, Vilmundur, Tardif, Jean-Claude, Lettre, Guillaume, t Hart, Leen M., Elders, Petra J.M., Rader, Daniel J., Damrauer, Scott M., Kumari, Meena, Kivimaki, Mika, van der Harst, Pim, Spector, Tim D., Loos, Ruth J.F., Province, Michael A., Parra, Esteban J., Cruz, Miguel, Psaty, Bruce M., Brandslund, Ivan, Pramstaller, Peter P., Rotimi, Charles N., Christensen, Kaare, Ripatti, Samuli, Widén, Elisabeth, Hakonarson, Hakon, Grant, Struan F.A., Kiemeney, Lambertus, de Graaf, Jacqueline, Loeffler, Markus, Kronenberg, Florian, Gu, Dongfeng, Erdmann, Jeanette, Schunkert, Heribert, Franks, Paul W., Linneberg, Allan, Jukema, J. Wouter, Khera, Amit V., Männikkö, Minna, Jarvelin, Marjo-Riitta, Kutalik, Zoltan, Francesco, Cucca, Mook-Kanamori, Dennis O., Willems van Dijk, Ko, Watkins, Hugh, Strachan, David P., Grarup, Niels, Sever, Peter, Poulter, Neil, Huey-Herng Sheu, Wayne, Rotter, Jerome I., Dantoft, Thomas M., Karpe, Fredrik, Neville, Matt J., Timpson, Nicholas J., Cheng, Ching-Yu, Wong, Tien-Yin, Khor, Chiea Chuen, Li, Hengtong, Sabanayagam, Charumathi, Peters, Annette, Gieger, Christian, Hattersley, Andrew T., Pedersen, Nancy L., Magnusson, Patrik K.E., Boomsma, Dorret I., de Geus, Eco J.C., Cupples, L. Adrienne, van Meurs, Joyce B.J., Ikram, Arfan, Ghanbari, Mohsen, Gordon-Larsen, Penny, Huang, Wei, Kim, Young Jin, Tabara, Yasuharu, Wareham, Nicholas J., Langenberg, Claudia, Zeggini, Eleftheria, Tuomilehto, Jaakko, Kuusisto, Johanna, Laakso, Markku, Ingelsson, Erik, Abecasis, Goncalo, Chambers, John C., Kooner, Jaspal S., de Vries, Paul S., Morrison, Alanna C., Hazelhurst, Scott, Ramsay, Michèle, North, Kari E., Daviglus, Martha, Kraft, Peter, Martin, Nicholas G., Whitfield, John B., Abbas, Shahid, Saleheen, Danish, Walters, Robin G., Holmes, Michael V., Black, Corri, Smith, Blair H., Baras, Aris, Justice, Anne E., Buring, Julie E., Ridker, Paul M., Chasman, Daniel I., Kooperberg, Charles, Tamiya, Gen, Yamamoto, Masayuki, van Heel, David A., Trembath, Richard C., Wei, Wei-Qi, Jarvik, Gail P., Namjou, Bahram, Hayes, M. Geoffrey, Ritchie, Marylyn D., Jousilahti, Pekka, Salomaa, Veikko, Hveem, Kristian, Åsvold, Bjørn Olav, Kubo, Michiaki, Kamatani, Yoichiro, Okada, Yukinori, Murakami, Yoshinori, Kim, Bong-Jo, Thorsteinsdottir, Unnur, Stefansson, Kari, Zhang, Jifeng, Chen, Y. Eugene, Ho, Yuk-Lam, Lynch, Julie A., Tsao, Philip S., Chang, Kyong-Mi, Cho, Kelly, O'Donnell, Christopher J., Gaziano, John M., Wilson, Peter, Mohlke, Karen L., Frayling, Timothy M., Hirschhorn, Joel N., Kathiresan, Sekar, Boehnke, Michael, Struan Grant, Natarajan, Pradeep, Sun, Yan V., Morris, Andrew P., Deloukas, Panos, Peloso, Gina, Assimes, Themistocles L., Willer, Cristen J., Zhu, Xiang, and Brown, Christopher D.

Published
2022
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4. Automated imaging-based abdominal organ segmentation and quality control in 20,000 participants of the UK Biobank and German National Cohort Studies

Author

Kart, Turkay, Fischer, Marc, Winzeck, Stefan, Glocker, Ben, Bai, Wenjia, Bülow, Robin, Emmel, Carina, Friedrich, Lena, Kauczor, Hans-Ulrich, Keil, Thomas, Kröncke, Thomas, Mayer, Philipp, Niendorf, Thoralf, Peters, Annette, Pischon, Tobias, Schaarschmidt, Benedikt M., Schmidt, Börge, Schulze, Matthias B., Umutle, Lale, Völzke, Henry, Küstner, Thomas, Bamberg, Fabian, Schölkopf, Bernhard, Rueckert, Daniel, and Gatidis, Sergios

Published
2022
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5. Better Together: Data Harmonization and Cross-Study Analysis of Abdominal MRI Data From UK Biobank and the German National Cohort

Author

Gatidis, Sergios, Kart, Turkay, Fischer, Marc, Winzeck, Stefan, Glocker, Ben, Bai, Wenjia, Bülow, Robin, Emmel, Carina, Friedrich, Lena, Kauczor, Hans-Ulrich, Keil, Thomas, Kröncke, Thomas, Mayer, Philipp, Niendorf, Thoralf, Peters, Annette, Pischon, Tobias, Schaarschmidt, Benedikt M., Schmidt, Börge, Schulze, Matthias B., Umutle, Lale, Völzke, Henry, Küstner, Thomas, Bamberg, Fabian, Schölkopf, Bernhard, and Rueckert, Daniel

Published
2022
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6. Childhood trauma and somatic and mental illness in adulthood—findings of the NAKO health study

Author

Klinger-König, Johanna, primary, Erhardt, Angelika, additional, Streit, Fabian, additional, Völker, Maja P., additional, Schulze, Matthias B., additional, Keil, Thomas, additional, Fricke, Julia, additional, Castell, Stefanie, additional, Klett-Tammen, Carolina J., additional, Pischon, Tobias, additional, Karch, André, additional, Teismann, Henning, additional, Michels, Karin B., additional, Greiser, K. Halina, additional, Becher, Heiko, additional, Karrasch, Stefan, additional, Ahrens, Wolfgang, additional, Meinke-Franze, Claudia, additional, Schipf, Sabine, additional, Mikolajczyk, Rafael, additional, Führer, Amand, additional, Brandes, Berit, additional, Schmidt, Börge, additional, Emmel, Carina, additional, Leitzmann, Michael, additional, Konzok, Julian, additional, Peters, Anette, additional, Obi, Nadia, additional, Brenner, Hermann, additional, Holleczek, Bernd, additional, Velásquez, Ilais Moreno, additional, Deckert, Jürgen, additional, Baune, Bernhard T., additional, Rietschel, Marcella, additional, Berger, Klaus, additional, and Grabe, Hans J., additional

Published
2024
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9. Blutdruckmessung in der NAKO – methodische Unterschiede, Blutdruckverteilung und Bekanntheit der Hypertonie im Vergleich zu anderen bevölkerungsbezogenen Studien in Deutschland

Author

Schikowski, Tamara, Wigmann, Claudia, Fuks, Kateryna B., Schipf, Sabine, Heier, Margit, Neuhauser, Hannelore, Sarganas, Giselle, Ahrens, Wolfgang, Becher, Heiko, Berger, Klaus, Brenner, Hermann, Castell, Stefanie, Damms-Machado, Antje, Dörr, Marcus, Ebert, Nina, Efremov, Ljupcho, Emmel, Carina, Felix, Stephan B., Fischer, Beate, Franzke, Claus-Werner, Gastell, Sylvia, Günther, Kathrin, Haerting, Johannes, Ittermann, Till, Jaeschke, Lina, Jagodzinski, Annika, Jöckel, Karl-Heinz, Kaaks, Rudolphe, Kalinowski, Sonja, Keil, Thomas, Kemmling, Yvonne, Kluttig, Alexander, Krist, Lilian, Kuss, Oliver, Legath, Nicole, Leitzmann, Michael, Lieb, Wolfgang, Löffler, Markus, Meinke-Franze, Claudia, Michels, Karin B., Mikolajczyk, Rafael, Moebus, Susanne, Nuding, Sebastian, Peters, Annette, Pischon, Tobias, Rückert-Eheberg, Ina-Maria, Schöttker, Ben, Schmidt, Börge, Schmidt, Carsten Oliver, Schulze, Matthias B., Stang, Andreas, Thiele, Inke, Thierry, Sigrid, Thorand, Barbara, Völzke, Henry, Waniek, Sabina, Werdan, Karl, Wirkner, Kerstin, and Greiser, Karin Halina

Published
2020
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10. Lungenfunktion in der NAKO Gesundheitsstudie: Methoden und erste Ergebnisse

Author

Karrasch, Stefan, Peters, Annette, Meisinger, Christa, Ferland, Maike, Jaeschke, Lina, Pischon, Tobias, Fricke, Julia, Keil, Thomas, Gastell, Sylvia, Schulze, Matthias, Brandes, Mirko, Günther, Kathrin, Kuß, Oliver, Schikowski, Tamara, Emmel, Carina, Jöckel, Karl-Heinz, Michels, Karin B., Franzke, Claus-Werner, Langer, Susan, Mikolajczyk, Rafael, Jagodzinski, Annika, Becher, Heiko, Castell, Stefanie, Kemmling, Yvonne, Waniek, Sabina, Lieb, Wolfgang, Wirkner, Kerstin, Loeffler, Markus, Greiser, Karin Halina, Kaaks, Rudolf, Legath, Nicole, Berger, Klaus, Schipf, Sabine, Hoffmann, Wolfgang, Sedlmeier, Anja, Leitzmann, Michael, Brenner, Hermann, Holleczek, Bernd, and Schulz, Holger

Published
2020
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11. Better Together

Author

Gatidis, Sergios, primary, Kart, Turkay, additional, Fischer, Marc, additional, Winzeck, Stefan, additional, Glocker, Ben, additional, Bai, Wenjia, additional, Bülow, Robin, additional, Emmel, Carina, additional, Friedrich, Lena, additional, Kauczor, Hans-Ulrich, additional, Keil, Thomas, additional, Kröncke, Thomas, additional, Mayer, Philipp, additional, Niendorf, Thoralf, additional, Peters, Annette, additional, Pischon, Tobias, additional, Schaarschmidt, Benedikt M., additional, Schmidt, Börge, additional, Schulze, Matthias B., additional, Umutle, Lale, additional, Völzke, Henry, additional, Küstner, Thomas, additional, Bamberg, Fabian, additional, Schölkopf, Bernhard, additional, and Rueckert, Daniel, additional

Published
2022
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12. Quality Control Matters: Automated Magnetic Resonance Imaging-based Abdominal Organ Segmentation in 20,000 Participants of the UK Biobank and German National Cohort Studies.

Author

Kart, Turkay, primary, Fischer, Marc, additional, Winzeck, Stefan, additional, Glocker, Ben, additional, Bai, Wenjia, additional, Bülow, Robin, additional, Emmel, Carina, additional, Friedrich, Lena, additional, Kauczor, Hans-Ulrich, additional, Keil, Thomas, additional, Kröncke, Thomas, additional, Mayer, Philipp, additional, Niendorf, Thoralf, additional, Peters, Annette, additional, Pischon, Tobias, additional, Schaarschmidt, Benedikt, additional, Schmidt, Börge, additional, Schulze, Matthias, additional, Umutlu, Lale, additional, Völzke, Henry, additional, Küstner, Thomas, additional, Bamberg, Fabian, additional, Schoelkopf, Bernhard, additional, Rückert, Daniel, additional, and Gatidis, Sergios, additional

Published
2022
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13. Better Together: Data Harmonization and Cross-Study Analysis of Abdominal MRI Data From UK Biobank and the German National Cohort.

Author

Gatidis, Sergios, Kart, Turkay, Fischer, Marc, Winzeck, Stefan, Glocker, Ben, Bai, Wenjia, Bülow, Robin, Emmel, Carina, Friedrich, Lena, Kauczor, Hans-Ulrich, Keil, Thomas, Kröncke, Thomas, Mayer, Philipp, Niendorf, Thoralf, Peters, Annette, Pischon, Tobias, Schaarschmidt, Benedikt M., Schmidt, Börge, Schulze, Matthias B., and Umutle, Lale

Published
2023
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14. Lifetime and current depression in the German National Cohort (NAKO)

Author

Streit, Fabian, Zillich, Lea, Schmiedek, Florian, Schmidt, Börge, Erhardt, Angelika, Deckert, Jürgen, Investigators, NAKO, Rietschel, Marcella, Berger, Klaus, Lieb, Wolfgang, Becher, Heiko, Obi, Nadia, Frank, Josef, Zeeb, Hajo, Ahrens, Wolfgang, Castell, Stefanie, Kemmling, Yvonne, Karch, André, Rübsamen, Nicole, Emmel, Carina, Jöckel, Karl-Heinz, Perna, Laura, Brenner, Hermann, Kleineidam, Luca, Kaaks, Rudolph, Greiser, Karin Halina, Michels, Karin B, Franzke, Claus-Werner, Peters, Annette, Fischer, Beate, Leitzmann, Michael, Amand, Führer, Mikolajczyk, Rafael, Keil, Thomas, Wagner, Michael, Fricke, Julia, Feinkohl, Insa, Pischon, Tobias, Schipf, Sabine, Hoffmann, Wolfgang, Baune, Bernhard T, Klinger-König, Johanna, Grabe, Hans J, Pabst, Alexander, and Riedel-Heller, Steffi G

Subjects
Psychiatry and Mental health, depressive symptoms, MINI interview, family history of depression, Medizin, ddc:610, PHQ-stress, PHQ-9, Biological Psychiatry
Abstract

The present study introduces the assessment of depression and depressive symptoms in the German National Cohort (NAKO), a population-based mega cohort. Distribution of core measures, and associations with sociodemographic factors are examined.The current analysis includes data from the first 101,667 participants (NAKO data freeze 100,000). Depression and depressive symptoms were assessed using a modified version of the depression section of the Mini-International Neuropsychiatric Interview (MINI), self-reported physician's diagnosis of depression, and the depression scale of the Patient Health Questionnaire (PHQ-9).A lifetime physician's diagnosis of depression was reported by 15.0% of participants. Of those, 47.6% reported having received treatment for depression within the last 12 months. Of the subset of 26,342 participants undergoing the full depression section of the modified MINI, 15.9% were classified by the MINI with a lifetime depressive episode. Based on the PHQ-9, 5.8% of the participants were classified as currently having a major or other depression by the diagnostic algorithm, and 7.8% according to the dimensional assessment (score ≥ 10). Increased frequency of depression measures and higher depression scores were observed in women and participants with lower education level or a family history of depression.The observed distributions of all depression measures and their associations with sociodemographic variables are consistent with the literature on depression. The NAKO represents a valuable epidemiologic resource to investigate depression, and the range of measures for lifetime and current depression allows users to select the most suitable instrument for their specific research question.

Published
2022

15. Framework and baseline examination of the German National Cohort (NAKO)

Author

Peters, Annette Michael, Greiser, Karin Halina, Göttlicher, Susanne, Ahrens, Wolfgang P., Albrecht, Maren, Bamberg, Fabian, Bärnighausen, Till Winfried, Becher, Heiko, Berger, Klaus, Beule, Achim, Boeing, Heiner, Bohn, Barbara, Bohnert, Kerstin, Braun, Bettina, Brenner, Hermann, Bülow, Robin, Castell, Stefanie, Damms-Machado, Antje, Dörr, Marcus, Ebert, Nina J., Ecker, Margit, Emmel, Carina, Fischer, Beate, Franzke, Claus Werner, Gastell, Sylvia, Giani, Guido, Günther, Matthias, Günther, Kathrin, Günther, Klaus Peter, Haerting, Johannes, Haug, Ulrike, Heid, Iris M., Heier, Margit, Heinemeyer, Diana, Hendel, Thomas, Herbolsheimer, Florian, Hirsch, Jochen Gunther, Hoffmann, Wolfgang U., Holleczek, Bernd, Hólling, Heike, Hörlein, Andreas J., Jöckel, Karl Heinz, Kaaks, Rudolf J., Karch, André, Karrasch, Stefan, Kartschmit, Nadja, Kauczor, Hans Ulrich, Keil, Thomas, Kemmling, Yvonne, Klee, Bianca, Klüppelholz, Birgit, Kluttig, Alexander, Kofink, Lisa, Köttgen, Anna, Kraft, Daniel, Krause, Gérard, Kretz, Lisa, Krist, Lilian, Kühnisch, Jan, Kuß, Oliver, Legath, Nicole, Lehnich, Anna Therese, Leitzmann, Michael Fred, Lieb, Wolfgang, Linseisen, Jakob P., Loeffler, Markus, Macdonald, Anke, Maier-Hein, Klaus Hermann Fritzsche, Mangold, Nina, Meinke-Franze, Claudia, Meisinger, Christa, Melzer, Juliane, Mergarten, Bjöorn, Michels, Karin B., Mikolajczyk, Rafael T., Moebus, Susanne, Mueller, Ulrich Otto, Nauck, Matthias A., Niendorf, Thoralf, Nikolaou, Konstantin, Obi, Nadia, Ostrzinski, Stefan, Panreck, Leo, Pigeot, Iris, Pischon, Tobias, Pschibul-Thamm, Irene, Rathmann, Wolfgang G., Reineke, Achim, Roloff, Stefanie, Rujescu, Dan, Rupf, Stefan, Sander, Oliver, Schikowski, Tamara, Schipf, Sabine M., Schirmacher, Peter, Schlett, Christopher L., Schmidt, Börge, Schmidt, Georg D., Schmidt, Martin, Schöne, Gina, and Publica

Subjects
Magnetic resonance imaging, Epidemiology, Life-style and socio-economic factors, Psychosocial factors, Functional impairments, Population-based cohort, Non-communicable diseases, Communicable diseases, Pre-clinical disease
Abstract

The German National Cohort (NAKO) is a multidisciplinary, population-based prospective cohort study that aims to investigate the causes of widespread diseases, identify risk factors and improve early detection and prevention of disease. Specifically, NAKO is designed to identify novel and better characterize established risk and protection factors for the development of cardiovascular diseases, cancer, diabetes, neurodegenerative and psychiatric diseases, musculoskeletal diseases, respiratory and infectious diseases in a random sample of the general population. Between 2014 and 2019, a total of 205,415 men and women aged 19–74 years were recruited and examined in 18 study centres in Germany. The baseline assessment included a face-to-face interview, self-administered questionnaires and a wide range of biomedical examinations. Biomaterials were collected from all participants including serum, EDTA plasma, buffy coats, RNA and erythrocytes, urine, saliva, nasal swabs and stool. In 56,971 participants, an intensified examination programme was implemented. Whole-body 3T magnetic resonance imaging was performed in 30,861 participants on dedicated scanners. NAKO collects follow-up information on incident diseases through a combination of active follow-up using self-report via written questionnaires at 2–3 year intervals and passive follow-up via record linkages. All study participants are invited for re-examinations at the study centres in 4–5 year intervals. Thereby, longitudinal information on changes in risk factor profiles and in vascular, cardiac, metabolic, neurocognitive, pulmonary and sensory function is collected. NAKO is a major resource for population-based epidemiology to identify new and tailored strategies for early detection, prediction, prevention and treatment of major diseases for the next 30 years.

Published
2022

16. Generalised anxiety and panic symptoms in the German National Cohort (NAKO)

Author

Erhardt, Angelika, Gelbrich, Götz, Grabe, Hans J, Rietschel, Marcella, Berger, Klaus, Deckert, Jürgen, Peters, Annette, Fischer, Beate, Leitzmann, Michael, Greiser, Karin Halina, Jaskulski, Stefanie, Franzke, Claus-Werner, Klinger-König, Johanna, Stocker, Hannah, Koch-Gallenkamp, Lena, Emmel, Carina, Stang, Andreas, Karch, André, Legath, Nicole, Mikolajczyk, Rafael, Führer, Amand-Gabriel, Feinkohl, Insa, Pischon, Tobias, Streit, Fabian, Willich, Stefan N, Fricke, Julia, Castell, Stefanie, Kemmling, Yvonne, Becher, Heiko, Obi, Nadia, Zeeb, Hajo, Ahrens, Wolfgang, Lieb, Wolfgang, Schmidt, Carsten Oliver, Kleineidam, Luca, Ostrzinski, Stefan, Riedel-Heller, Steffi G, Investigators, NAKO, Schmidt, Börge, Schmiedek, Florian, and Wagner, Michael

Subjects
education.field_of_study, Generalized anxiety disorder, German National Cohort, business.industry, Generalised anxiety, Panic disorder, Population, Medizin, Panic, medicine.disease, Patient Health Questionnaire, Psychiatry and Mental health, Cohort, medicine, Anxiety, PHQ-Panic, panic attacks, ddc:610, medicine.symptom, education, business, Biological Psychiatry, Depression (differential diagnoses), GAD-7, Clinical psychology
Abstract

Objectives Anxiety disorders (AD) are common in the general population leading to high emotional distress and disability. The German National Cohort (NAKO) is a population based mega-cohort study, examining participants in 16 German regions. The present study includes data of the first 101,667 participants and investigates the frequency and severity of generalized anxiety symptoms and panic attacks (PA). Methods The Generalized Anxiety Disorder Symptoms Scale (GAD-7) and the first part of the Patient Health Questionnaire Panic Disorder (PHQ-PD) were filled out by NAKO participants (93,002). We examined the correlation of GAD-7 and PHQ-PD with demographic variables, stress (PHQ-Stress), depression (PHQ-9) and childhood trauma (CTS). Results The total proportion of prior life-time diagnoses of AD in the NAKO cohort reached 7.8%. Panic attacks were reported by 6.0% and possible/probable current GAD symptoms in 5.2% of the examined participants. Higher anxiety severity was associated with female sex, lower education level, German as foreign language and younger age as well as high perceived stress and depression. Conclusions Clinically relevant GAD symptoms as well as panic attacks are frequent in the NAKO, are associated with sociodemographic factors and high anxiety symptoms are accompanied by pronounced stress and depression levels.

Published
2022
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17. Better Together

Author

Gatidis, Sergios, Kart, Turkay, Fischer, Marc, Winzeck, Stefan, Glocker, Ben, Bai, Wenjia, Bülow, Robin, Emmel, Carina, Friedrich, Lena, Kauczor, Hans-Ulrich, Keil, Thomas, Kröncke, Thomas, Mayer, Philipp, Niendorf, Thoralf, Peters, Annette, Pischon, Tobias, Schaarschmidt, Benedikt M., Schmidt, Börge, Schulze, Matthias B., Umutle, Lale, Völzke, Henry, Küstner, Thomas, Bamberg, Fabian, Schölkopf, Bernhard, and Rueckert, Daniel

Published
2023
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18. Socioeconomic position is associated with N-terminal pro-brain natriuretic peptide (NT-proBNP): Results of the population-based Heinz Nixdorf Recall study

Author

Rudman, Marina, Frank, Mirjam, Emmel, Carina, Matusch, Emanuel, Kara, Kaffer, Mahabadi, Amir Abbas, Erbel, Raimund, Jöckel, Karl-Heinz, Dragano, Nico, and Schmidt, Börge

Subjects
Male, Endocrine Disorders, Science, Cardiology, Social Sciences, Blood Pressure, Cardiovascular Medicine, Biochemistry, Vascular Medicine, Body Mass Index, Medical Conditions, Endocrinology, Sociology, Natriuretic Peptide, Brain, Medicine and Health Sciences, Diabetes Mellitus, Coronary Heart Disease, Humans, Public and Occupational Health, Social Stratification, cardiovascular diseases, ddc:610, Medizinische Fakultät » Universitätsklinikum Essen » Institut für Medizinische Informatik, Biometrie und Epidemiologie, Antihypertensive Agents, Medizinische Fakultät » Universitätsklinikum Essen » Klinik für Kardiologie und Angiologie, Aged, Cholesterol, HDL, Smoking, Biology and Life Sciences, Cholesterol, LDL, Cardiovascular Disease Risk, Middle Aged, Lipids, Socioeconomic Aspects of Health, Peptide Fragments, Health Care, Cholesterol, Social Class, Cardiovascular Diseases, Heart Disease Risk Factors, Metabolic Disorders, Medicine, Female, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Research Article
Abstract

ObjectivesN-Terminal pro Brain Natriuretic Peptide (NT-proBNP) is a diagnostic marker for heart failure and a prognostic factor for cardiovascular disease (CVD). The aim of this study was to examine the association of socioeconomic position (SEP) with NT-proBNP while assessing sex-differences and the impact of CVD risk factors and prevalent CVD on the association.MethodsBaseline data of 4598 participants aged 45-75 years of the Heinz Nixdorf Recall Study were used. Income and education were used as SEP indicators. Age- and sex-adjusted linear regression models were fitted to calculate effect size estimates and 95% confidence intervals (95%-CIs) for the total effect of SEP indicators on NT-proBNP, while potential mediation was assessed by additionally accounting for traditional CVD risk factors (i.e., systolic blood pressure, HDL cholesterol, LDL cholesterol, diabetes, anti-hypertensive medication, lipid-lowering medication, BMI, current smoking). Education and income were included separately in the models.ResultsWith an age- and sex-adjusted average change in NT-proBNP of -6.47% (95%-CI: -9.91; -2.91) per 1000€, the association between income and NT-proBNP was more pronounced compared to using education as a SEP indicator (-0.80% [95%-CI: -1.92; 0.32] per year of education). Sex-stratified results indicated stronger associations in men (-8.43% [95%-CI: -13.21; -3.38] per 1000€; -1.63% [95%-CI: -3.23; -0.001] per year of education) compared to women (-5.10% [95%-CI: -9.82; -0.01] per 1000€; -1.04% [95%-CI: -2.59; 0.50] per year of education). After adjusting for CVD risk factors some of the observed effect size estimates were attenuated, while the overall association between SEP indicators and NT-proBNP was still indicated. The exclusion of participants with prevalent coronary heart disease or stroke did not lead to a substantial change in the observed associations.ConclusionsIn the present study associations of education and income with NT-proBNP were observed in a population-based study sample. Only parts of the association were explained by traditional CVD risk factors, while there were substantial sex-differences in the strength of the observed association. Overt coronary heart disease or stroke did not seem to trigger the associations.

Published
2021

20. Interaction of polygenetic effect allele sum scores for serum lipid levels by socioeconomic position in a population-based cohort

Author

Emmel, Carina, Dragano, Nico, Frank, Mirjam, Erbel, Raimund, Jöckel, Karl-Heinz, and Schmidt, Börge

Subjects
ddc: 610, lipids (amino acids, peptides, and proteins), 610 Medical sciences, Medicine
Abstract

Introduction: Serum lipid concentrations (SLC) of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL) and total cholesterol (TC) are modifiable risk factors for cardiovascular disease (CVD). Genetic research has outlined associations between various genetic loci and[for full text, please go to the a.m. URL], 65th Annual Meeting of the German Association for Medical Informatics, Biometry and Epidemiology (GMDS), Meeting of the Central European Network (CEN: German Region, Austro-Swiss Region and Polish Region) of the International Biometric Society (IBS)

Published
2021
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22. Socioeconomic position is associated with Nterminal pro-brain natriuretic peptide (NTproBNP) : Results of the population-based Heinz Nixdorf Recall study

Author

Rudman, Marina, Frank, Mirjam, Emmel, Carina, Matusch, Emanuel, Kara, Kaffer, Mahabadi, Amir Abbas, Erbel, Raimund, Jöckel, Karl-Heinz, Dragano, Nico, and Schmidt, Börge

Subjects
Medizin, cardiovascular diseases
Abstract

Objectives N-Terminal pro Brain Natriuretic Peptide (NT-proBNP) is a diagnostic marker for heart failure and a prognostic factor for cardiovascular disease (CVD). The aim of this study was to examine the association of socioeconomic position (SEP) with NT-proBNP while assessing sex-differences and the impact of CVD risk factors and prevalent CVD on the association. Methods Baseline data of 4598 participants aged 45-75 years of the Heinz Nixdorf Recall Study were used. Income and education were used as SEP indicators. Age- and sex-adjusted linear regression models were fitted to calculate effect size estimates and 95% confidence intervals (95%-CIs) for the total effect of SEP indicators on NT-proBNP, while potential mediation was assessed by additionally accounting for traditional CVD risk factors (i.e., systolic blood pressure, HDL cholesterol, LDL cholesterol, diabetes, anti-hypertensive medication, lipidlowering medication, BMI, current smoking). Education and income were included separately in the models. Results With an age- and sex-adjusted average change in NT-proBNP of -6.47% (95%-CI: -9.91; -2.91) per 1000€, the association between income and NT-proBNP was more pronounced compared to using education as a SEP indicator (-0.80% [95%-CI: -1.92; 0.32] per year of education). Sex-stratified results indicated stronger associations in men (-8.43% [95%-CI: -13.21; -3.38] per 1000€; -1.63% [95%-CI: -3.23; -0.001] per year of education) compared to women (-5.10% [95%-CI: -9.82; -0.01] per 1000€; -1.04% [95%-CI: -2.59; 0.50] per year of education). After adjusting for CVD risk factors some of the observed effect size estimates were attenuated, while the overall association between SEP indicators and NT-proBNP was still indicated. The exclusion of participants with prevalent coronary heart disease or stroke did not lead to a substantial change in the observed associations. Conclusions In the present study associations of education and income with NT-proBNP were observed in a population-based study sample. Only parts of the association were explained by traditional CVD risk factors, while there were substantial sex-differences in the strength of the observed association. Overt coronary heart disease or stroke did not seem to trigger the associations. OA Förderung 2021

Published
2021

23. Loneliness during the first wave of the SARS-CoV-2 pandemic : results of the German National Cohort (NAKO)

Author

Berger, Klaus, Riedel-Heller, Steffi, Pabst, Alexander, Rietschel, Marcella, Richter, Dirk, Lieb, Wolfgang, Hermes, Anne, Becher, Heiko, Obi, Nadia, Günther, Kathrin, Ahrens, Wolfgang, Castell, Stefanie, Kemmling, Yvonne, Karch, André, Legath, Nicole, Schmidt, Börge, Emmel, Carina, Kuß, Oliver, Schikowski, Tamara, Koch-Gallenkamp, Lena, Holleczek, Bernd, Damms-Machado, Antje, Halina Greiser, Karin, Michels, Karin B., Franzke, Claus-Werner, Peters, Annette, Thierry, Sigrid, Fischer, Beate, Leitzmann, Michael, Löffler, Markus, Wirkner, Kerstin, Mikolajczyk, Rafael, Rujescu, Dan, Gastell, Sylvia, Schulze, Matthias B., Krist, Lilian, Fricke, Julia, Jaeschke, Lina, Pischon, Tobias, Meinke-Franze, Claudia, and Völzke, Henry

Subjects
Medizin
Abstract

Background: Early during the pandemic and the following protective countermeasures, an interest in the consequences of the enacted restriction of social contacts for the mental health of the population arose. Loneliness describes the perceived quality of one’s own contacts and relationships with other individuals. Several prior studies reported associations of loneliness with different somatic and psychiatric disorders. Aim: To analyse the frequency of loneliness and its association with depression and anxiety symptoms in the first wave of the pandemic in Germany in May 2020. Methods: The German National Cohort (NAKO) had recruited and examined 205,000 individuals aged 20 to 69 years in 18 study centres across Germany between 2014 and 2019. The follow-up examination was temporarily stopped due to the pandemic between March and July 2020. In this period a COVID-related questionnaire was developed and sent to all participants. We analysed the first 113,928 questionnaires that were sent back within four weeks in May 2020. Loneliness was assessed with the three-item UCLA Loneliness Scale and anxiety and depression symptoms were collected using the PHQ‑9 and GAD‑7 scales from the Patient Health Questionnaire. Results: Among the NAKO participants, 31.7% reported to be lonely in May 2020. Women and young adults reported more loneliness than men and older adults. With increasing scores of loneliness, the severity of depression and anxiety symptoms also steadily increased. Individuals who were lonely during the pandemic had already reported higher PHQ‑9 and GAD‑7 scores during the baseline examination on average 2.5 years earlier, compared to those who did not feel lonely. Conclusions: Among participants of the German National Cohort, we observed an increase in loneliness during the first wave of the SARS-CoV‑2 pandemic in spring 2020 and a strong relationship of increasing loneliness with decreasing mental health.

Published
2021

24. Self‐reported medication intake vs information from other data sources such as pharmacy records or medical records: Identification and description of existing publications, and comparison of agreement results for publications focusing on patients with cancer ‐ a systematic review

Author

Brüne, Manuela, primary, Emmel, Carina, additional, Meilands, Gisela, additional, Andrich, Silke, additional, Droste, Sigrid, additional, Claessen, Heiner, additional, Jülich, Fabian, additional, and Icks, Andrea, additional

Published
2021
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25. [Lung function in the German National Cohort: methods and initial results]

Author

Karrasch, Stefan, Peters, Annette, Meisinger, Christa, Ferland, Maike, Jaeschke, Lina, Pischon, Tobias, Fricke, Julia, Keil, Thomas, Gastell, Sylvia, Schulze, Matthias, Brandes, Mirko, Günther, Kathrin, Kuß, Oliver, Schikowski, Tamara, Emmel, Carina, Jöckel, Karl-Heinz, Michels, Karin B, Franzke, Claus-Werner, Langer, Susan, Mikolajczyk, Rafael, Jagodzinski, Annika, Becher, Heiko, Castell, Stefanie, Kemmling, Yvonne, Waniek, Sabina, Lieb, Wolfgang, Wirkner, Kerstin, Loeffler, Markus, Greiser, Karin Halina, Kaaks, Rudolf, Legath, Nicole, Berger, Klaus, Schipf, Sabine, Hoffmann, Wolfgang, Sedlmeier, Anja, Leitzmann, Michael, Brenner, Hermann, Holleczek, Bernd, Schulz, Holger, and HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.

Subjects
German National Cohort, Breath Tests, Exhalation, Spirometry, Germany, Medizin, COPD, Humans, FeNO, respiratory system, Asthma, circulatory and respiratory physiology, respiratory tract diseases
Abstract

Background: A nationwide assessment of the respiratory status on the basis of standardized lung function measurements has so far not been available in Germany. The present work describes the lung function tests in the German National Cohort (GNC) and presents initial results based on the GNC Midterm Baseline Dataset. Material and Methods: The assessment of lung function in the GNC comprised spirometry (level 1) and the determination of exhaled nitric oxide (FeNO, level 2). Our quality assurance concept included regular training of lung function test procedures at various GNC sites, interim evaluations of test quality, as well as regular calibration/measurement checks of test equipment. For spirometry, we established a stepwise procedure for offline quality control based on raw flow volume curves. Results: In the present dataset (n = 101,734), spirometry was available for 86,893 study participants and FeNO was available for 15,228 participants. The average (±SD) FEV₁ Z score (according to GLI 2012) was −0.321 ± 1.047, the FVC Z score was −0.153 ± 0.941, and the FEV₁/FVC Z score was −0.337 ± 0.901. The difference in FEV₁/FVC between current smokers and never-smokers increased with age. The average FeNO was 14.2 ÷ 2.0 ppb. Current smoking reduced FeNO levels by 43%, whereas respiratory allergy increased FeNO levels by 16% in nonsmokers. Discussion: The results of spirometry and the FeNO measurements are in the expected range with regard to their distributions and correlates. The GNC provides a valuable basis for future investigations of respiratory health and its determinants as well as research into the prevention of respiratory diseases in Germany.

Published
2020

26. Socio-demographic and employment-related factors in the German National Cohort (GNC; NAKO Gesundheitsstudie)

Author

Dragano, N., Dragano, Nico, Reuter, Marvin, Greiser, Karin Halina, Becher, Heiko, Zeeb, Hajo, Mikolajczyk, Rafael, Kluttig, Alexander, Leitzmann, Michael, Fischer, Beate, Jöckel, Karl Heinz, Emmel, Carina, Krause, Gérard, Castell, Stefanie, Damms-Machado, Antje, Obi, Nadia, Schikowski, Tamara, Kuss, Oliver, Hoffmann, Wolfgang, Schipf, Sabine, Pischon, Tobias, Jaeschke, Lina, Krist, Lilian, Keil, Thomas, Lieb, Wolfgang, Holleczek, Bernd, Brenner, Hermann, Wirkner, Kerstin, Loeffler, Markus, Michels, Karin B., Franzke, Claus Werner, Peters, Annette, Linseisen, Jakob, Berger, Klaus, Legath, Nicole, Ahrens, Wolfgang, Lampert, Thomas, Schmidt, Börge, and HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.

Subjects
German National Cohort, Social epidemiology, Social inequality, Socio-economic position, Body mass index
Abstract

igh levels of adiposity in the population have a major impact on various diseases, but previous epidemiologic studies have largely been restricted to simple anthropometric measures such as the body mass index (BMI), an imperfect predictor of disease risk. There is a critical need for the use of improved measures of relative weight and body composition in large-scale, population-based research. The current article presents initial descriptive results of body composition and fat distribution based on the midterm baseline dataset of the German National Cohort, which included 101,817 participants who were examined in 18 study centers in Germany between March 2014 and March 2017. The anthropometric measures encompassed body weight, height, waist and hip circumference, bioelectrical impedance analysis (BIA), sonography of abdominal adipose tissue, 3D-body scanning, and magnetic resonance imaging. BMI analyses showed that 46.2% of men and 29.7% of women were overweight and 23.5% of men and 21.2% of women were obese. On average, women in almost all age groups demonstrated more subcutaneous adipose tissue layer thickness than men. The mean values of visceral adipose tissue layer thickness, on the other hand, were higher among men than among women in all age groups and increased continuously across age groups in both sexes. The comprehensive assessment of body composition and fat distribution provides novel future opportunities for detailed epidemiologic analyses of overweight and adiposity in relation to the development of chronic diseases.

Published
2020

27. Soziodemografische und erwerbsbezogene Merkmale in der NAKO Gesundheitsstudie

Author

Dragano, Nico, primary, Reuter, Marvin, additional, Greiser, Karin Halina, additional, Becher, Heiko, additional, Zeeb, Hajo, additional, Mikolajczyk, Rafael, additional, Kluttig, Alexander, additional, Leitzmann, Michael, additional, Fischer, Beate, additional, Jöckel, Karl-Heinz, additional, Emmel, Carina, additional, Krause, Gérard, additional, Castell, Stefanie, additional, Damms-Machado, Antje, additional, Obi, Nadia, additional, Schikowski, Tamara, additional, Kuss, Oliver, additional, Hoffmann, Wolfgang, additional, Schipf, Sabine, additional, Pischon, Tobias, additional, Jaeschke, Lina, additional, Krist, Lilian, additional, Keil, Thomas, additional, Lieb, Wolfgang, additional, Holleczek, Bernd, additional, Brenner, Hermann, additional, Wirkner, Kerstin, additional, Loeffler, Markus, additional, Michels, Karin B., additional, Franzke, Claus-Werner, additional, Peters, Annette, additional, Linseisen, Jakob, additional, Berger, Klaus, additional, Legath, Nicole, additional, Ahrens, Wolfgang, additional, Lampert, Thomas, additional, and Schmidt, Börge, additional

Published
2020
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28. Einsamkeit während der ersten Welle der SARS-CoV-2-Pandemie – Ergebnisse der NAKO-Gesundheitsstudie.

Author

Berger, Klaus, Riedel-Heller, Steffi, Pabst, Alexander, Rietschel, Marcella, Richter, Dirk, NAKO-Konsortium, Lieb, Wolfgang, Hermes, Anne, Becher, Heiko, Obi, Nadia, Günther, Kathrin, Ahrens, Wolfgang, Castell, Stefanie, Kemmling, Yvonne, Karch, André, Legath, Nicole, Schmidt, Börge, Emmel, Carina, Kuß, Oliver, and Schikowski, Tamara

Abstract

Copyright of Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021
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29. [Socio-demographic and employment-related factors in the German National Cohort (GNC; NAKO Gesundheitsstudie)].

Author

Dragano N, Reuter M, Greiser KH, Becher H, Zeeb H, Mikolajczyk R, Kluttig A, Leitzmann M, Fischer B, Jöckel KH, Emmel C, Krause G, Castell S, Damms-Machado A, Obi N, Schikowski T, Kuss O, Hoffmann W, Schipf S, Pischon T, Jaeschke L, Krist L, Keil T, Lieb W, Holleczek B, Brenner H, Wirkner K, Loeffler M, Michels KB, Franzke CW, Peters A, Linseisen J, Berger K, Legath N, Ahrens W, Lampert T, and Schmidt B

Subjects
Cohort Studies, Female, Germany, Humans, Male, Middle Aged, Socioeconomic Factors, Unemployment, Employment, Health Status
Abstract

Background: In epidemiologic studies, standardised measurement of socio-demographic and employment-related factors is becoming increasingly important, as variables such as gender, age, education or employment status are factors influencing health and disease risks., Aims: The article gives an overview of the scientific background and assessment of socio-demographic factors in the German National Cohort Study. In addition, the distribution of individual characteristics in the cohort as well as relationships with health-related measures are presented by way of example., Material and Methods: The analysis is based on the data of the first half of the baseline survey (n = 101,724). On this basis, we present the distribution of key socio-demographic characteristics and analyse relationships with exemplary selected health indicators (body mass index, self-reported health) to assess the validity of socio-demographic data measurements., Results: On average, study participants were 52.0 years old (SD = 12.4). Of the participants, 53.6% were women, 54.3% had high education, 60.1% were married and 72% were employed while 3.4% were unemployed. Well-established correlations between socio-demographic factors and health could be reproduced with the German National Cohort data. For example, low education, old age and unemployment were associated with an increased prevalence of obesity and poor self-reported health., Discussion: The German National Cohort provides a comprehensive measurement of socio-demographic characteristics. Combined with a wide range of health data and the longitudinal measurements available in the future, this opens up new opportunities for health science and social epidemiological research in Germany.

Published
2020
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