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395 results on '"Emmons, C"'

1. Universal DNA methylation age across mammalian tissues.

Author

Lu, A, Fei, Z, Haghani, A, Robeck, T, Zoller, J, Li, C, Lowe, R, Yan, Q, Zhang, J, Vu, H, Ablaeva, J, Acosta-Rodriguez, V, Adams, D, Almunia, J, Aloysius, A, Ardehali, R, Arneson, A, Baker, C, Banks, G, Belov, K, Bennett, N, Black, P, Bors, E, Breeze, C, Brooke, R, Brown, J, Carter, G, Caulton, A, Cavin, J, Chakrabarti, L, Chatzistamou, I, Chen, H, Cheng, K, Chiavellini, P, Choi, O, Clarke, S, Cooper, L, Cossette, M, Day, J, DeYoung, J, DiRocco, S, Dold, C, Ehmke, E, Emmons, C, Emmrich, S, Erbay, E, Erlacher-Reid, C, Faulkes, C, Ferguson, S, Flower, J, Gaillard, J, Garde, E, Gerber, L, Gladyshev, V, Gorbunova, V, Goya, R, Grant, M, Green, C, Hales, E, Hanson, M, Hart, D, Haulena, M, Herrick, K, Hogan, A, Hogg, C, Hore, T, Izpisua Belmonte, J, Jasinska, A, Jones, G, Jourdain, E, Kashpur, O, Katcher, H, Katsumata, E, Kaza, V, Kiaris, H, Kobor, M, Kordowitzki, P, Koski, W, Krützen, M, Kwon, S, Larison, B, Lee, S, Lehmann, M, Lemaitre, J, Lim, A, Lin, D, Lindemann, D, Little, T, Macoretta, N, Maddox, D, Matkin, C, Mattison, J, McClure, M, Mergl, J, Meudt, J, Montano, G, Mozhui, K, Munshi-South, J, Naderi, A, and Nagy, M

Subjects
Humans, Mice, Animals, DNA Methylation, Epigenesis, Genetic, Aging, Longevity, Mammals
Abstract

Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the development of universal pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation Consortium, which encompass 59 tissue types across 185 mammalian species. These predictive models estimate mammalian tissue age with high accuracy (r > 0.96). Age deviations correlate with human mortality risk, mouse somatotropic axis mutations and caloric restriction. We identified specific cytosines with methylation levels that change with age across numerous species. These sites, highly enriched in polycomb repressive complex 2-binding locations, are near genes implicated in mammalian development, cancer, obesity and longevity. Our findings offer new evidence suggesting that aging is evolutionarily conserved and intertwined with developmental processes across all mammals.

Published
2023

2. Author Correction: Universal DNA methylation age across mammalian tissues

Author

Lu, A. T., Fei, Z., Haghani, A., Robeck, T. R., Zoller, J. A., Li, C. Z., Lowe, R., Yan, Q., Zhang, J., Vu, H., Ablaeva, J., Acosta-Rodriguez, V. A., Adams, D. M., Almunia, J., Aloysius, A., Ardehali, R., Arneson, A., Baker, C. S., Banks, G., Belov, K., Bennett, N. C., Black, P., Blumstein, D. T., Bors, E. K., Breeze, C. E., Brooke, R. T., Brown, J. L., Carter, G. G., Caulton, A., Cavin, J. M., Chakrabarti, L., Chatzistamou, I., Chen, H., Cheng, K., Chiavellini, P., Choi, O. W., Clarke, S. M., Cooper, L. N., Cossette, M. L., Day, J., DeYoung, J., DiRocco, S., Dold, C., Ehmke, E. E., Emmons, C. K., Emmrich, S., Erbay, E., Erlacher-Reid, C., Faulkes, C. G., Ferguson, S. H., Finno, C. J., Flower, J. E., Gaillard, J. M., Garde, E., Gerber, L., Gladyshev, V. N., Gorbunova, V., Goya, R. G., Grant, M. J., Green, C. B., Hales, E. N., Hanson, M. B., Hart, D. W., Haulena, M., Herrick, K., Hogan, A. N., Hogg, C. J., Hore, T. A., Huang, T., Izpisua Belmonte, J. C., Jasinska, A. J., Jones, G., Jourdain, E., Kashpur, O., Katcher, H., Katsumata, E., Kaza, V., Kiaris, H., Kobor, M. S., Kordowitzki, P., Koski, W. R., Krützen, M., Kwon, S. B., Larison, B., Lee, S. G., Lehmann, M., Lemaitre, J. F., Levine, A. J., Li, C., Li, X., Lim, A. R., Lin, D. T. S., Lindemann, D. M., Little, T. J., Macoretta, N., Maddox, D., Matkin, C. O., Mattison, J. A., McClure, M., Mergl, J., Meudt, J. J., Montano, G. A., Mozhui, K., Munshi-South, J., Naderi, A., Nagy, M., Narayan, P., Nathanielsz, P. W., Nguyen, N. B., Niehrs, C., O’Brien, J. K., O’Tierney Ginn, P., Odom, D. T., Ophir, A. G., Osborn, S., Ostrander, E. A., Parsons, K. M., Paul, K. C., Pellegrini, M., Peters, K. J., Pedersen, A. B., Petersen, J. L., Pietersen, D. W., Pinho, G. M., Plassais, J., Poganik, J. R., Prado, N. A., Reddy, P., Rey, B., Ritz, B. R., Robbins, J., Rodriguez, M., Russell, J., Rydkina, E., Sailer, L. L., Salmon, A. B., Sanghavi, A., Schachtschneider, K. M., Schmitt, D., Schmitt, T., Schomacher, L., Schook, L. B., Sears, K. E., Seifert, A. W., Seluanov, A., Shafer, A. B. A., Shanmuganayagam, D., Shindyapina, A. V., Simmons, M., Singh, K., Sinha, I., Slone, J., Snell, R. G., Soltanmaohammadi, E., Spangler, M. L., Spriggs, M. C., Staggs, L., Stedman, N., Steinman, K. J., Stewart, D. T., Sugrue, V. J., Szladovits, B., Takahashi, J. S., Takasugi, M., Teeling, E. C., Thompson, M. J., Van Bonn, B., Vernes, S. C., Villar, D., Vinters, H. V., Wallingford, M. C., Wang, N., Wayne, R. K., Wilkinson, G. S., Williams, C. K., Williams, R. W., Yang, X. W., Yao, M., Young, B. G., Zhang, B., Zhang, Z., Zhao, P., Zhao, Y., Zhou, W., Zimmermann, J., Ernst, J., Raj, K., and Horvath, S.

Published
2023
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31. Conception, fetal growth, and calving seasonality of harbor porpoise (Phocoenaphocoena) in the Salish Sea waters of Washington, USA, and southern British Columbia, Canada

Author

Norman, S.A., primary, Hanson, M.B., additional, Huggins, J., additional, Lambourn, D., additional, Calambokidis, J., additional, Cottrell, P., additional, Greene, A., additional, Raverty, S., additional, Berta, S., additional, Dubpernell, S., additional, Klope, M., additional, Olson, J.K., additional, Jeffries, S.J., additional, Carrasco, M., additional, Souze, V., additional, Elsby, A., additional, McLean, C., additional, Carlson, B., additional, Emmons, C., additional, and Gaydos, J.K., additional

Published
2018
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35. Conception, fetal growth, and calving seasonality of harbor porpoise ( Phocoena phocoena) in the Salish Sea waters of Washington, USA, and southern British Columbia, Canada.

Author

Norman, S.A., Hanson, M.B., Huggins, J., Lambourn, D., Calambokidis, J., Cottrell, P., Greene, A., Raverty, S., Berta, S., Dubpernell, S., Klope, M., Olson, J.K., Jeffries, S.J., Carrasco, M., Souze, V., Elsby, A., McLean, C., Carlson, B., Emmons, C., and Gaydos, J.K.

Subjects
HARBOR porpoise, ANIMAL reproduction, FETAL development, SEASON of birth, ANIMAL species
Abstract

Copyright of Canadian Journal of Zoology is the property of Canadian Science Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2018
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36. Libri novi

Author

Cooke, Wm. Bridge, Smith, Alexander H., Mrak, E. M., Emmons, C. W., and Chichester, C. O.

Published
1962
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37. Libri novi

Author

Kuehn, Harold H., Emmons, C. W., Ajello, Libero, and Bridge Cooke, Wm.

Published
1961
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43. National probability samples in studies of low-prevalence diseases. Part I: Perspectives and lessons from the HIV cost and services utilization study

Author

Shapiro, M F, Berk, M L, Berry, S H, Emmons, C A, Athey, L A, Hsia, D C, Leibowitz, A A, Maida, C A, Marcus, M, Perlman, J F, Schur, C L, Schuster, M A, Senterfitt, J W, and Bozzette, S A

Subjects
Data Collection, HIV Infections, Health Care Costs, Professional-Patient Relations, Health Services, United States, Random Allocation, Interinstitutional Relations, Research Design, Data Interpretation, Statistical, Outcome Assessment, Health Care, Prevalence, Humans, Health Services Research, Prospective Studies, Research Article, Probability
Abstract

OBJECTIVE: To examine the trade-offs inherent in selecting a sample design for a national study of care for an uncommon disease, and the adaptations, opportunities and costs associated with the choice of national probability sampling in a study of HIV/AIDS. SETTING: A consortium of public and private funders, research organizations, community advocates, and local providers assembled to design and execute the study. DESIGN: Data collected by providers or collected for administrative purposes are limited by selectivity and concerns about validity. In studies based on convenience sampling, generalizability is uncertain. Multistage probability sampling through households may not produce sufficient cases of diseases that are not highly prevalent. In such cases, an attractive alternative design is multistage probability sampling through sites of care, in which all persons in the reference population have some chance of random selection through their medical providers, and in which included subjects are selected with known probability. DATA COLLECTION AND PRINCIPAL FINDINGS: Multistage national probability sampling through providers supplies uniquely valuable information, but will not represent populations not receiving medical care and may not provide sufficient cases in subpopulations of interest. Factors contributing to the substantial cost of such a design include the need to develop a sampling frame, the problems associated with recruitment of providers and subjects through medical providers, the need for buy-in from persons affected by the disease and their medical practitioners, as well as the need for a high participation rate. Broad representation from the national community of scholars with relevant expertise is desirable. Special problems are associated with organization of the research effort, with instrument development, and with data analysis and dissemination in such a consortium. CONCLUSIONS: Multistage probability sampling through providers can provide unbiased, nationally representative data on persons receiving regular medical care for uncommon diseases and can improve our ability to accurately study care and its outcomes for diseases such as HIV/AIDS. However, substantial costs and special circumstances are associated with the implementation of such efforts.

Published
1999

47. 14

Author

Emmons, Cai

Published
2018

48. 54

Author

Emmons, Cai

Published
2018

49. 63

Author

Emmons, Cai

Published
2018

50. 8

Author

Emmons, Cai

Published
2018

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