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13. Assessment of the F@rma-ción learning resources

Author

Gilabert, J.A., Pombar, A.S., Pedraja, M., Fernández, J.G., Toribio, M.S., Encinas, T., and Otros

Subjects
Métodos docentes alternativos, 3109 Ciencias Veterinarias, Veterinaria, Valoración métodos docentes, Metaconocimiento, Valoración proyecto
Abstract

Resúmenes IV Congreso VetDoc de Docencia Veterinaria, León 2017 (6-7 de Julio) [ES] En el presente trabajo presentamos parte de los objetivos desarrollados en este proyecto, concretamente los relacionados con la exploración del metaconocimiento de los estudiantes en cuanto a la adquisición de competencias, tanto transversales como específicas de farmacología mediante la realización de las actividades y utilización de los recursos generados en el repositorio de F@RMA-CIÓN.

Published
2017

14. Hunters of the 'lost competencies'

Author

Encinas, T., Gilabert, J.A., Ros Rodríguez, J.M, Sainz, A., and Otros

Subjects
3109 Ciencias Veterinarias, Veterinaria, Competencias transversales, Actividades extracurriculares, Formación extracurricular, Competencias genéricas
Abstract

Resúmenes IV Congreso VetDoc de Docencia Veterinaria, León 2017 (6-7 de Julio) [ES] En el Grado en Veterinaria, igual que en otras titulaciones, se han definido competencias generales, de grado y de título, y específicas, algunas de ellas transversales, que el estudiante debe alcanzar para garantizar su formación y así conseguir su graduación (ANECA, 2005). La consecución de las competencias específicas del curriculum del Grado en Veterinaria están vinculadas a los programas de las asignaturas y enmarcadas en la actividad docente de los departamentos; sin embargo, no sucede así con todas las competencias generales, principalmente en su componente actitudinal (competencia académica).

Published
2017

18. Patterns of corpora lutea growth and progesterone secretion in sows with thrifty genotype and leptin resistance due to leptin receptor gene polymorphisms (Iberian pig)

Author

Gonzalez-Añover, P., Encinas, T., Torres-Rovira, L., Sanz, E., Pallares, P., Ros, J. M., Gomez-Izquierdo, E., Sanchez-Sanchez, R., and Gonzalez-Bulnes, A.

Subjects
endocrine system, urogenital system, reproductive and urinary physiology, hormones, hormone substitutes, and hormone antagonists
Abstract

The current study aimed to compare luteal function, as measured by corpora lutea dynamics and progesterone secretion, in 10 sows with obesity/leptin resistance genotype (Iberian pig) and 10 females of lean commercial crosses (Large White×Landrace). In all the animals, the oestrous cycle was synchronized with progestagens, and ovulation was induced by exogenous gonadotrophins. Thereafter, number and size of follicles and plasma oestradiol concentration were determined at oestrus detection, and number and size of corpora lutea and progesterone concentration were evaluated from Day 4 to 12 of the cycle. There were no differences between genotypes in follicle population and oestradiol concentration, and ovulation rate (15.2±1.3 in Iberian vs 12.7±1.8 in LWxL sows); however, there was a higher percentage of Iberian than control sows showing luteal cysts (66.7% vs 30%, respectively; p

Published
2011

19. Advanced onset of puberty in gilts of thrifty genotype (Iberian pig)

Author

Gonzalez-Añover, P., Encinas, T., Gomez-Izquierdo, E., Sanz, E., Letelier, C. A., Torres-Rovira, L., Pallares, P., Sanchez-Sanchez, R., and Gonzalez-Bulnes, A.

Subjects
humanities
Abstract

Contents The Iberian pig is an autochthonous breed of the Mediterranean area, reared extensively in the central and southern areas of Spain and Portugal and that is known worldwide for the production of Iberian ham. The characteristics of the Iberian ham are related to its abundance of intramuscular fat, owing to the high capacity of the pig to accumulate fat under its skin and between the muscular fibres. This ability to store excess fat enables survival during periods of scarcity and it has been found in other antique animal breeds and even in humans, being named as the thrifty genotype. The reproductive management of the Iberian pig, in spite of a lack of accurate information unlike in other swine breeds, is based on the assumption of lower reproductive precocity and efficiency than the modern commercial breeds. The current study characterized and compared the onset of puberty in gilts of Iberian breed and meat commercial crosses (Large White × Landrace) reared in the same conditions by assessing weekly plasma progesterone profiles. At the end of the experimental period, when the gilts became 180 days old, the percentage of Iberian females that had reached puberty was 72.2%, with a mean age and weight of 160.5 ± 2.6 days and 92.9 ± 4.7 kg, respectively. The percentage of Large White × Landrace cross-breed females reaching puberty at 180 days was only 15% (p < 0.05). The mean age and weight were 165.0 ± 4.1 days and 107.8 ± 2.2 kg (p < 0.05), respectively. Thus, converse to the traditional assumption, onset of puberty was advanced in Iberian gilts. These results are important for the reproductive management of the Iberian pig but, at the same time, may set the basis for future studies on the metabolism-reproduction link and, specifically, on the possible relationship between earlier accumulation of fat and attainment of puberty. © 2009 Blackwell Verlag GmbH.

Published
2010

20. Pharmacokinetics of meloxicam after intravenous, intramuscular and oral administration of a single dose to African grey parrots ( Psittacus erithacus).

Author

Montesinos, A., Ardiaca, M., Gilabert, J. A., Bonvehí, C., Oros, J., and Encinas, T.

Subjects
PHARMACOKINETICS, ANTI-inflammatory agents, NONSTEROIDAL anti-inflammatory agents, AVIAN anatomy, LIQUID chromatography
Abstract

Meloxicam is a nonsteroidal anti-inflammatory drug commonly used in avian species. In this study, the pharmacokinetic parameters for meloxicam were determined following single intravenous (i.v.), intramuscular (i.m.) and oral (p.o.) administrations of the drug (1 mg/kg·b.w.) in adult African grey parrots ( Psittacus erithacus; n = 6). Serial plasma samples were collected and meloxicam concentrations were determined using a validated high-performance liquid chromatography assay. A noncompartmental pharmacokinetic analysis was performed. No undesirable side effects were observed during the study. After i.v. administration, the volume of distribution, clearance and elimination half-life were 90.6 ± 4.1 mL/kg, 2.18 ± 0.25 mL/h/kg and 31.4 ± 4.6 h, respectively. The peak mean ± SD plasma concentration was 8.32 ± 0.95 μg/ mL at 30 min after i.m. administration. Oral administration resulted in a slower absorption ( tmax = 13.2 ± 3.5 h; Cmax = 4.69 ± 0.75 μg/ mL) and a lower bioavailability (38.1 ± 3.6%) than for i.m. (78.4 ± 5.5%) route. At 24 h, concentrations were 5.90 ± 0.28 μg/ mL for i.v., 4.59 ± 0.36 μg/ mL for i.m. and 3.21 ± 0.34 μg/ mL for p.o. administrations and were higher than those published for Hispaniolan Amazon parrots at 12 h with predicted analgesic effects. [ABSTRACT FROM AUTHOR]

Published
2017
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21. Pharmacokinetics and local tolerance of cefovecin sodium after intra-articular administration in horses.

Author

Pérez‐Nogués, M., Encinas, T., and López‐SanRoman, J.

Subjects
*INFECTIOUS arthritis, *HORSE diseases, *TREATMENT of horse diseases, *PHARMACOKINETICS, *VETERINARY pharmacology, *DISEASE risk factors, *THERAPEUTICS
Abstract

Searching for new therapeutic options against septic arthritis in horses, this research was focused on the study of the kinetics and local side effects after the intra-articular treatment of horses with cefovecin sodium. A single dose (240 mg) of the drug (Convenia®) was administered into the radiocarpal joint of adult healthy horses ( n = 6), and drug concentrations in plasma and synovial fluid were determined by high-performance liquid chromatography ( HPLC). Local tolerance was also studied based on the modification of different joint physiopathological parameters ( pH, cellular, and protein concentration in synovial fluid). Although no clinically relevant joint damage was noticed, significant increases in the protein concentrations at 5 min and in the cellular concentration at 30 min after cefovecin administration were observed in the treated radiocarpal joints. The duration of the cefovecin above the minimal inhibitory concentration ( MIC) ≤1 μg/ mL was 28.80 ± 2.58 h in the radiocarpal joint and 16.00 ± 2.86 h in plasma. The results of this study showed that intra-articular administration of cefovecin sodium in horses could be considered in the future to manage septic arthritis in horses, as it offers a good pharmacokinetic behavior and good local tolerance. [ABSTRACT FROM AUTHOR]

Published
2017
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22. Residuos tisulares de nicotinato de norfloxacina administrado por vía oral en cerdos

Author

DÍAZ, D., PICCO, E. J., ENCINAS, T., RUBIO, M., LITTERIO, N. J., and BOGGIO, J. C.

Abstract

Norfloxacin nicotinate (NN) is a fluoroquinolone antibacterial agent with a high antimicrobial activity against a very wide range of gram negative and a number of gram positive aerobes as well as most pathogenic mycoplasmas.Tissular and blood concentrations of a comercial preparation of NN (Vetantril-N", Vetanco) in pigs after oral administration were determined. The drug was diluted in distilled water and administered to ten healthy male pigs through a naso-esophagic tube at a daily dose of 18 mg/kg by five consecutive days. To adjust the dose each individual was weighed out before every administration.Animals were sacrificed in pairs at 24, 48, 96, 144 and 192 hours after last administration. Tissular (included fat, muscle, liver and kidney) and plasma samples were collected from each pig.NN concentrations were determined by high performance liquid chromatography using UV detection.Results demonstrate good NN gastrointestinal absorption, with shorter persistance in plasma and fat, intermediate persistance in muscle and longer in liver and kidney, which should be taken into account when determining withdrawal times on this domestic specie., Nicotinato de norfloxacina (NN) es una fluoroquinolona antibacteriana de elevada actividad antimicrobiana sobre un amplio rango de gérmenes gram negativos y ciertos gram positivos aeróbicos, así como también micoplasmas patógenos. Se determinaron las concentraciones plasmáticas y tisulares de una preparación comercial de NN (Vetantril-N". Vetanco) en cerdos administrada por vía oral. La droga se diluyó en agua destilada y fue administrada a diez cerdos machos clínicamente sanos mediante sonda naso-esofágica a una dosis diaria de 18 mg/kg. Cada individuo fue pesado antes de cada administración para ajustar la dosis. Los animales fueron sacrificados de a pares, a las 24, 48, 96, 144 y 192 horas posteriores a la última administración. Muestras de tejido (incluyendo grasa, músculo, hígado y riñón) y plasma se recogieron luego de la muerte de cada cerdo. Las concentraciones de NN fueron determinadas por cromatografía líquida de alta performance con detector UV. Los resultados demostraron buena absorción gastrointestinal de NN, con corta persistencia en plasma y grasa, intermedia en músculo y prolongada en hígado y riñón, lo cual debería considerarse para determinar tiempos de retirada para consumo en esta especie doméstica. &nbsp

Published
2001

49. Advanced Onset of Puberty in Gilts of Thrifty Genotype (Iberian Pig).

Author

Gonzalez-Añover, P, Encinas, T, Gomez-Izquierdo, E, Sanz, E, Letelier, CA, Torres-Rovira, L, Pallares, P, Sanchez-Sanchez, R, and Gonzalez-Bulnes, A

Subjects
*PUBERTY, *SOWS, *ANIMAL breeds, *ANIMAL reproduction, *PROGESTERONE, *ANIMAL breeding, *METABOLISM
Abstract

The Iberian pig is an autochthonous breed of the Mediterranean area, reared extensively in the central and southern areas of Spain and Portugal and that is known worldwide for the production of Iberian ham. The characteristics of the Iberian ham are related to its abundance of intramuscular fat, owing to the high capacity of the pig to accumulate fat under its skin and between the muscular fibres. This ability to store excess fat enables survival during periods of scarcity and it has been found in other antique animal breeds and even in humans, being named as the thrifty genotype. The reproductive management of the Iberian pig, in spite of a lack of accurate information unlike in other swine breeds, is based on the assumption of lower reproductive precocity and efficiency than the modern commercial breeds. The current study characterized and compared the onset of puberty in gilts of Iberian breed and meat commercial crosses (Large White × Landrace) reared in the same conditions by assessing weekly plasma progesterone profiles. At the end of the experimental period, when the gilts became 180 days old, the percentage of Iberian females that had reached puberty was 72.2%, with a mean age and weight of 160.5 ± 2.6 days and 92.9 ± 4.7 kg, respectively. The percentage of Large White × Landrace cross-breed females reaching puberty at 180 days was only 15% (p < 0.05). The mean age and weight were 165.0 ± 4.1 days and 107.8 ± 2.2 kg (p < 0.05), respectively. Thus, converse to the traditional assumption, onset of puberty was advanced in Iberian gilts. These results are important for the reproductive management of the Iberian pig but, at the same time, may set the basis for future studies on the metabolism-reproduction link and, specifically, on the possible relationship between earlier accumulation of fat and attainment of puberty. [ABSTRACT FROM AUTHOR]

Published
2010
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50. Timing of Preovulatory LH Surge and Ovulation in Superovulated Sheep are Affected by Follicular Status at Start of the FSH Treatment.

Author

Veiga-Lopez, A., Encinas, T., McNeilly, A. S., and Gonzalez-Bulnes, A.

Subjects
*OVULATION, *SHEEP, *ESTRONE, *EWES, *MAMMAL reproduction, *FOLLICLE-stimulating hormone
Abstract

Contents The aims of this study were to evaluate the chronology of periovulatory events (oestrus behaviour, LH surge and ovulation) in 16 superovulated Manchega sheep and to determine whether follicular status at start of the FSH supply might affect their occurrence. Mean timing for onset of oestrus behaviour was detected at 28.1 ± 0.7 h after sponge withdrawal; the preovulatory LH surge and ovulation started at 37.2 ± 0.7 h and 65.4 ± 0.7 h after progestagen withdrawal, respectively. The intervals between oestrus, LH surge and ovulation were affected by a high individual variability, which might be the cause for reported decreased efficiency in embryo production. Current results also addressed the role of follicular status at start of the superovulatory treatment on the preovulatory LH surge and the ovulation. The interval LH surge-ovulation was increased in ewes with a growing dominant follicle at starting the FSH treatment (32.3 ± 0.9 vs 28.6 ± 0.5 h, p < 0.05). The developmental stage of the largest follicle at starting the superovulatory treatment also affected occurrence of LH surge and ovulation; follicles in growing phase advanced the occurrence of the LH surge and ovulation when compared to decreasing follicles (33.0 ± 1.0 vs 43.5 ± 1.1 h, p < 0.05, for LH peak and 60.7 ± 1.1 vs 72.8 ± 1.2 h, p < 0.05, for ovulation). Thus, only ewes with growing follicles ovulated prior to 55 h after sponge withdrawal; conversely, no sheep with decreasing follicles ovulated earlier than 67 h, when an 85.7% of the ewes bearing growing follicles has ovulated at 63 h. [ABSTRACT FROM AUTHOR]

Published
2008
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