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1. Cardiovascular dysfunction and catecholamine cardiomyopathy in pheochromocytoma patients and their reversal following surgical cure: Results of a prospective case-control study

Author: Agarwal, Gaurav, Sadacharan, Dhalapathy, Kapoor, Aditya, Batra, Aditya, Dabadghao, Preeti, Chand, Gyan, Mishra, Anjali, Agarwal, Amit, Verma, Ashok K., and Mishra, Saroj K.
Published: 2011
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2. Recovery pattern of patients with osteitis fibrosa cystica in primary hyperparathyroidism after successful parathyroidectomy

Author: Agarwal, Gaurav, Mishra, Saroj K., Kar, Dilip K., Singh, Anil K., Arya, Vivek, Gupta, Sushil K., and Mithal, Ambrish
Published: 2002
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3. Study of Oxidative Stress Marker Serum Paraoxonase in Metabolic Syndrome

Author: Mukund Ramchandra Mogarekar, Arati Adhe-Rojekar, Mohit Vijay Rojekar, and Turk J Endocrinol Metab
Subjects: medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, lactonase, 030204 cardiovascular system & hematology, medicine.disease_cause, lcsh:Diseases of the endocrine glands. Clinical endocrinology, metabolic syndrome, Arylesterase, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Internal Medicine, medicine, oxidative stress, lcsh:RC648-665, biology, Cholesterol, business.industry, arylesterase, Paraoxonase, medicine.disease, PON1, Endocrinology, chemistry, biology.protein, Metabolic syndrome, business, Body mass index, Oxidative stress, Lipoprotein
Abstract: Purpose: The metabolic syndrome (MetS) is a constellation of interrelated risk factors of metabolic origin that appear to promote development of cardiovascular disease. It has become one of the most important topics for this decade because of marked increase in cardiovascular disease associated with risk factors. Paraoxonase (PON) is a family of three enzymes, PON1, PON2 and PON3, the gene which is located on chromosome 7. This is high-density lipoprotein (HDL)-associated enzyme with antioxidant activity. The objective of the present study aimed at measurement of PON1 activities in patients with MetS, to compare PON1 activities in patients with MetS with those in controls and assess its relationship with the lipoproteins in serum. Material and Method: Cases were included as per the criteria put forth by the International Diabetes Federation. Serum PON1 activities were measured using spectrophotometer. Statistical analysis was done using SPSS 20.0. Result: Serum PON1 arylesterase and lactonase activities were found to be reduced significantly in patients with MetS than in controls. PON1 activities showed a positive correlation with HDL, fasting blood glucose and diastolic blood pressure. Linear regression analysis showed a significant correlation between PON1 activities and body mass index. Discussion: From the present study, it is clear that reduction in PON1 activities in MetS is mainly due either to abnormalities with synthesis or secretion of HDL cholesterol or oxidative stress as a consequence of excess production of the free radicals. This study also iterates that it is the quality and not the quantity of HDL cholesterol is important while studying the pathophysiology of MetS.
Published: 2016

4. 'Sicilian Register of Thyroid Cancer': Descriptive, clinical and of risk factors epidemiology. Preliminary data

Author: PELLEGRITI G, S. ARENA, C. SCOLLO, R. VIGNERI, A. VIOLI, F. VERMIGLIO, P. RICHIUSA, A. MANIGLIA, L. GAMBINO, G. D'AZZO', M. ATTARD, G. DARDANONI, A. MIRA, F. TRIMARCHI J. ENDOCRINOL INVEST SUPPL TO NO, GIORDANO, Carla, PELLEGRITI G, S ARENA, C SCOLLO, R VIGNERI, A VIOLI, F VERMIGLIO, P RICHIUSA, GIORDANO C, A MANIGLIA, L GAMBINO, G D'AZZO', M ATTARD, G DARDANONI, A MIRA, and F TRIMARCHI J ENDOCRINOL INVEST SUPPL TO NO
Published: 2004

5. POTENTIAL ROLE OF INTERLEUKIN-1 AT THE PERI-OVULATION STAGE IN A SPECIES OF PLACENTAL VIVIPAROUS REPTILE, THE THREE-TOED SKINK, CHALCIDES CHALCIDES (SQUAMATA: SCINCIDAE)

Author: ROMAGNOLI R, CATENI C, BIGLIARDI E, PAULESU L. R.E.P.R. BIOL ENDOCRINOL, GUARINO, FABIO MARIA, Romagnoli, R, Cateni, C, Guarino, FABIO MARIA, Bigliardi, E, and BIOL ENDOCRINOL, PAULESU L. R. E. P. R.
Abstract: This article is available from: http://www.RBEj.com/content/1/1/60
Published: 2003

6. Association between the expression of E1A oncogene and increased sensitivity to growth inhibition induced by sustained levels of cAMP in rat thyroid cells

Author: VILLONE G, CHIEFFI P, PICASCIA A, STANZIONE R, SANTORO M, FUSCO, ALFREDO, TRAMONTANO, DONATELLA, EUR J. ENDOCRINOL, DE VITA, GABRIELLA, Villone, G, DE VITA, Gabriella, Chieffi, P, Picascia, A, Stanzione, R, Santoro, M, Fusco, Alfredo, Tramontano, Donatella, and EUR J., Endocrinol
Published: 2000

7. Analysis of voice in patients with untreated active acromegaly

Author: Bogazzi, Fausto, Nacci, A, Campomori, A, LA VELA, R, Rossi, G, Lombardi, M, Fattori, Bruno, Bartalena, L, Ursino, F, Martino, Enio, and Mar, J. ENDOCRINOL I. N. V. E. S. T.
Published: 2010

8. EFFEcts of somatostatin analogues on acromegalic cardiomyopathy: results from a prospective study using cardiac magnetic resonance

Author: Bogazzi, Fausto, Lombardi, M, Strata, E, Aquaro, G, Urbani, C, DI BELLO, Vitantonio, Cosci, C, Sardella, C, Talini, E, Martino, Enio, and Feb, J. ENDOCRINOL I. N. V. E. S. T.
Published: 2010

9. Plasma total and acylated Ghrelin concentrations in patients with clinical and subclinical thyroid dysfunction

Author: Tanda, Ml, Lombardi, V, Genovesi, M, Ultimieri, F, Lai, A, Gandolfo, M, DALLE MULE, I, Grasso, Lucia, Bogazzi, Fausto, Broglio, F, Ghigo, E, Martino, Enio, Bartalena, L, and Jan, J. ENDOCRINOL I. N. V. E. S. T.
Published: 2009

10. Regulation of mitochondrial oxidative events in pancreatic islets.

Author: Regulation of mitochondrial oxidative events in pancreatic islets. (Contact Group "Endocrine Pancreas" (FRSM) & Belgian Soc. Endocrinol. 01.12.1990: U.C.L. Louvain-la-Neuve,), Rasschaert, Joanne, Regulation of mitochondrial oxidative events in pancreatic islets. (Contact Group "Endocrine Pancreas" (FRSM) & Belgian Soc. Endocrinol. 01.12.1990: U.C.L. Louvain-la-Neuve,), and Rasschaert, Joanne
Abstract: 0, info:eu-repo/semantics/nonPublished
Published: 1990

11. Contributors

Author: Argyridis, Savvas, Arulkumaran, Sabaratnam, Chandraharan, Edwin, Ayres de Campos, Diogo, Gibb, Donald, Muhunthan, Kopalasuntharam, Penna, Leonie, and Steer, Philip J.
Published: 2017
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12. Effet of aminooxyacetate upon ionic fluxes induced by nutrient secretagogues in the pancreatic B-cell

Author: Groupes de Contact F.R.S.M. & Soc. Endocrinol. (27.11.1982: Louvain), Lebrun, Philippe, Malaisse, Willy, Herchuelz, André, Groupes de Contact F.R.S.M. & Soc. Endocrinol. (27.11.1982: Louvain), Lebrun, Philippe, Malaisse, Willy, and Herchuelz, André
Abstract: info:eu-repo/semantics/nonPublished
Published: 1982

13. Inhibition of the Na+-K+ ATPase and the stimulatory effect of glucose on 86Rb efflux in pancreatic B-cell

Author: Groupes de Contact F.R.S.M. & Soc. Endocrinol. (27.11.1982: Louvain), Herchuelz, André, Lebrun, Philippe, Malaisse, Willy, Groupes de Contact F.R.S.M. & Soc. Endocrinol. (27.11.1982: Louvain), Herchuelz, André, Lebrun, Philippe, and Malaisse, Willy
Abstract: info:eu-repo/semantics/nonPublished
Published: 1982

14. Glucose prevents death of alloxan-treated B cells

Author: Groupes de Contact F.R.S.M. & Soc. Endocrinol. (27.11.1982: Louvain), Pipeleers, Daniel, Gorus, Frans K, Van de Winkel, Marnix De, Malaisse, Willy, Groupes de Contact F.R.S.M. & Soc. Endocrinol. (27.11.1982: Louvain), Pipeleers, Daniel, Gorus, Frans K, Van de Winkel, Marnix De, and Malaisse, Willy
Abstract: info:eu-repo/semantics/nonPublished
Published: 1982

15. Failure of long-term therapy with sodium valproate in Cushing's disease

Author: Colao, A, Pivonello, R, Tripodi, Fs, Orio, Francesco, Ferone, D, Cerbone, G, Di Somma, C, Merola, B, 1997 Jul Aug, Lombardi G. J. Endocrinol I. n. v. e. s. t., Pmid:, 20:387 9. 2., Colao, Annamaria, Pivonello, Rosario, F. S., Tripodi, Orio, Francesco, D., Ferone, G., Cerbone, DI SOMMA, Carolina, Merola, Bartolomeo, and Lombardi, Gaetano
Subjects: Adult, Male, Cushing's disease, endocrine system, medicine.medical_specialty, Pituitary gland, Hydrocortisone, Adenoma, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Sodium, chemistry.chemical_element, Gastroenterology, Cushing syndrome, Endocrinology, Adrenocorticotropic Hormone, Internal medicine, medicine, Humans, Treatment Failure, Long term therapy, Cushing Syndrome, Chemotherapy, business.industry, Valproic Acid, Middle Aged, medicine.disease, Positive response, medicine.anatomical_structure, chemistry, Female, business, sodium valproate, hormones, hormone substitutes, and hormone antagonists
Abstract: The aim of the current study was to evaluate the effectiveness of a long-term treatment with sodium valproate in 19 patients with Cushing's disease. Before therapy beginning, the patients were subjected to acute test with 600 mg sodium valproate. Then, they were subjected to a 3-month therapy with sodium valproate at the dose of 600 mg/day before surgery (presurgical study). The 7 patients not surgically cured were subjected again to a 3-month therapy with sodium valproate at the dose of 600 mg/day after surgery (postsurgical study). Circulating ACTH and cortisol and urinary free cortisol levels were evaluated before and monthly after the beginning of the therapy. A decrease of plasma ACTH and serum cortisol levels greater than 50% of baseline was considered as positive response to acute test whereas the normalization of plasma ACTH, serum cortisol and urinary free cortisol levels and the clinical remission were considered as positive response to the long-term treatment. At acute test, 8 patients were considered responders and 11 patients non-responders. In no patient plasma ACTH, serum cortisol and urinary free cortisol were normalized during the long-term treatment. Urinary free cortisol levels significantly decreased (483.2 +/- 33.8 vs 699.4 +/- 67.0 micrograms/24 h), whereas plasma ACTH (302.8 +/- 17.7 vs 183.3 +/- 25.0 ng/l) and serum cortisol (466.5 +/- 23.2 vs 356.7 +/- 19.6 micrograms/l) significantly increased during sodium valproate administration in the 19 patients enrolled in the presurgical study. Plasma ACTH (247.7 +/- 22.3 vs 168.6 +/- 15.0 ng/l), serum cortisol (387.4 +/- 35.8 vs 282.0 +/- 16.0 micrograms/l) and urinary free cortisol (370.9 +/- 70.6 vs 261.3 +/- 37.8 micrograms/24 h) levels significantly increased in the 7 patients enrolled in the postsurgical study. No patient had clinical remission of Cushing's disease. In conclusion, the current study showed that long-term therapy with sodium valproate is not useful in the therapeutic management of Cushing's disease neither as alternative nor as adjunctive therapy to surgery.

16. The Therapeutical Role of Continuous Intra-femoral Artery Infusion of Urokinase on Diabetic Foot Ulcers

Author: Xiang Guang-da, Director of Endocrinol Dept.
Published: 2023

17. Physiology of pregnancy, Labor and Puerperium

Author: Frandsen, V. Aasted, primary, Stakemann, Georg, additional, and Endocrinol, Aeta, additional
Published: 1964
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18. Physiology of pregnancy, Labor and Puerperium

Author: V. Aasted Frandsen, Georg Stakemann, and Aeta Endocrinol
Subjects: medicine.medical_specialty, Pregnancy, Urinary excretion, Obstetrics, business.industry, medicine, Obstetrics and Gynecology, Physiology, General Medicine, business, medicine.disease
Published: 1964
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19. Virilizations, are they always adrenal hyperplasias or tumors?

Author: Jimenez, Ana Belen Ariza, Tejedor, Beatriz Martin, Lopez-Siguero, Juan Pedro, [Jimenez, Ana Belen Ariza] Hosp Reg Univ Materno Infantil, Secc Endocrinol Infantil, UGC Pediat, Malaga, Spain, [Tejedor, Beatriz Martin] Hosp Reg Univ Materno Infantil, Secc Endocrinol Infantil, UGC Pediat, Malaga, Spain, and [Lopez-Siguero, Juan Pedro] Hosp Reg Univ Materno Infantil, Secc Endocrinol Infantil, UGC Pediat, Malaga, Spain
Published: 2022

20. miR-21 mimic blocks obesity in mice: A novel therapeutic option

Author: Carlos López Gómez, Said Lhamyani, Mercedes Clemente-Postigo, Adriana-Mariel Gentile, Rosa M. Giráldez-Pérez, Nabil Hajji, Rajaa El Bekay, Abdelkrim Hmadcha, Julián Salas, Silvana Y. Romero-Zerbo, Francisco Javier Bermúdez-Silva, Gabriel Olveira, Wilfredo Oliva Olivera, Hatem Zayed, Francisco J. Tinahones, Mónica Feijóo-Cuaresma, [Lhamyani, Said] Univ Malaga, Hosp Reg Univ, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Campus Teatinos, Malaga 29010, Spain, [Gentile, Adriana-Mariel] Univ Malaga, Hosp Reg Univ, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Campus Teatinos, Malaga 29010, Spain, [Romero-Zerbo, Silvana Yanina] Univ Malaga, Hosp Reg Univ, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Campus Teatinos, Malaga 29010, Spain, [Bermudez-Silva, Francisco Javier] Univ Malaga, Hosp Reg Univ, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Campus Teatinos, Malaga 29010, Spain, [Olveira, Gabriel] Univ Malaga, Hosp Reg Univ, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Campus Teatinos, Malaga 29010, Spain, [El Bekay, Rajaa] Univ Malaga, Hosp Reg Univ, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Campus Teatinos, Malaga 29010, Spain, [Giraldez-Perez, Rosa M.] Univ Cordoba, Dept Biol Celular Fisiol & Inmunol, Cordoba 14004, Spain, [Feijoo-Cuaresma, Monica] Univ Malaga, Unidad Imagen Mol UIM, Ctr Invest Med Sanitarias CIMES, Malaga 2010, Spain, [Romero-Zerbo, Silvana Yanina] Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain, [Bermudez-Silva, Francisco Javier] Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain, [Hmadcha, Abdelkrim] Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain, [Olveira, Gabriel] Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain, [Clemente-Postigo, Mercedes] Univ Cordoba, Dept Cell Biol Physiol & Immunol, Maimonides Biomed Res Inst Cordoba IMIBIC, Reina Sofia Univ Hosp, Cordoba 14004, Spain, [Zayed, Hatem] Qatar Univ, Coll Hlth Sci, Dept Biomed Sci, QU Hlth, Doha 2713, Qatar, [Olivera, Wilfredo Oliva] Hosp Univ Virgen de la Victoria, Inst Invest Biomed Malaga IBIMA, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Unidad Gest Clin Endocrinol & Nutr, Madrid, Spain, [Tinahones, Francisco J.] Hosp Univ Virgen de la Victoria, Inst Invest Biomed Malaga IBIMA, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Unidad Gest Clin Endocrinol & Nutr, Madrid, Spain, [Salas, Julian] Carlos Haya Univ Hosp, Cardiovasc Surg Dept, Malaga 29009, Spain, [Lopez Gomez, Carlos] Hosp Univ Virgen de la Victoria, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Aparato Digest, Malaga 29010, Spain, [Hmadcha, Abdelkrim] Univ Pablo de Olavide, Fundat FAID, Seville, Spain, [Hajji, Nabil] Imperial Coll London, Fac Med, Dept Surg & Canc, London W12 0HS, England, [El Bekay, Rajaa] Spanish Biomed Res Ctr Physiopathol Obes & Nutr C, Madrid, Spain, ISCIII, Fondo Europeo de Desarrollo Regional (FEDER) -Union Europea (UE), Consejeria de Salud, Junta de Andalucia, Spain, FEDER, Servicio Andaluz de Salud, Regional Ministry of Health of the Andalusian Government, Andalusia, Spain, Consejeria de Econ-omia, Empresas y Universidades, Malaga University, Ministerio de Ciencia, Innovacion y Universi-dades (Spain), and Consejeria de Economia, Industria, Conocimiento y Univer-sidades (Junta de Andalucia), Spain
Subjects: obesity, Adipose-tissue dysfunction, uncoupling protein 1, Adipose tissue, White, Expression, Context (language use), White adipose tissue, RM1-950, Biology, Gene, Drug Discovery, microRNA, Brown adipose tissue, medicine, Inhibition, browning, Adipocyte, diabetes, TMEM26, Brown, brown adipose tissue, thermogenesis, Insulin-resistance, Thermogenin, adipose tissue, Vascular endothelial growth factor A, medicine.anatomical_structure, Fat, Differentiation, Cancer research, Molecular Medicine, Original Article, Therapeutics. Pharmacology, miR-21, Thermogenesis, metabolism
Abstract: MicroRNAs (miRNAs) are promising drug targets for obesity and metabolic disorders. Recently, miRNA mimics are providing a unique mechanism of action that guides the process for drug development and sets out the context of their therapeutic application. miRNA (miR)-21 expression in white adipose tissue (WAT) has been associated with obesity. We aimed to analyze miR-21 expression levels in relation to diabetes and obesity to determine the effect that miR-21 mimic has on processes involved in WAT functionality, to dissect the underlying molecular mechanisms, and to study the potential therapeutic application of the miR-21 mimic against obesity. We found higher miR-21 levels in WAT from non-diabetic obese compared to normoweight humans and mice. Moreover, in 3T3-L1 adipocytes, miR-21 mimic affect genes involved in WAT functionality regulation and significantly increase the expression of genes involved in browning and thermogenesis. Interestingly, in vivo treatment with the miR-21 mimic blocked weight gain induced by a high-fat diet in obese mice, without modifying food intake or physical activity. This was associated with metabolic enhancement, WAT browning, and brown adipose tissue (AT) thermogenic programming through vascular endothelial growth factor A (VEGF-A), p53, and transforming growth factor β1 (TGF-β1) signaling pathways. Our findings suggest that miR-21 mimic-based therapy may provide a new opportunity to therapeutically manage obesity and consequently, its associated alterations., Graphical abstract, miR-21 mimic could serve as a potential therapeutic tool to control obesity by delaying energy storage and promoting energy expenditure in adipose tissue.
Published: 2021

21. Parental perception of factors related to obesity and overweight in adolescents: a qualitative study

Author: Elena Carrasco-Solis, Marta, Fernandez-Alcantara, Manuel, Inmaculada Fernandez-Avalos, Ma, Maria Gomez-Vida, Jose, Perez-lanez, Ricardo, Laynez-Rubio, Carolina, [Elena Carrasco-Solis, Marta] Hosp Clin San Cecilio PTS, Neuropsicol Clin, Unidad Neurol Neuropsicol Neurodesarrollo & Psico, Serv Pediat, Granada, Spain, [Laynez-Rubio, Carolina] Hosp Clin San Cecilio PTS, Neuropsicol Clin, Unidad Neurol Neuropsicol Neurodesarrollo & Psico, Serv Pediat, Granada, Spain, [Fernandez-Alcantara, Manuel] Univ Alicante, Dept Psicol Salud, Alicante, Spain, [Inmaculada Fernandez-Avalos, Ma] Univ Alicante, Dept Psicol Salud, Alicante, Spain, [Maria Gomez-Vida, Jose] Hosp Clin San Cecilio PTS, Serv Pediat, Endocrinol, Granada, Spain, [Perez-lanez, Ricardo] Hosp Clin San Cecilio PTS, Serv Pediat, Endocrinol, Granada, Spain, and [Laynez-Rubio, Carolina] Inst Invest Biosanitaria IBS, Granada, Spain
Subjects: Qualitative research, Prevalence, Pediatric obesity, Overweight, Skipping breakfast, Healthy behaviors, Children, Adolescence
Abstract: Introduction: Childhood and adolescent obesity and overweight is associated with serious physical, psychological and social health complications. The aim of the present study was to explore in depth parents' perceptions of factors associated with obesity and overweight in their adolescent children.Methods: A descriptive phenomenological qualitative study was carried out through focus groups. Twenty-five mothers and fathers whose children were diagnosed with obesity or overweight who were under follow-up in the Paediatric Department of the Hospital Clinico San Cecilio (Spain) participated. Data analysis was performed with Atlas.ti 6.2 software through thematic analysis.Results: Lack of limit with food was perceived as a source of conflict and anxiety. The most common unhealthy lifestyle habits were sedentary, lack of time for cooking and skiping breakfast. Parents' perceptions of the negative effects of obesity are related to traumatic events, effects on body image, isolation and discrimination and the occurrence of other diseases associated with excess weight. Modulating factors of eating behavior were observed such as the promotion of healthy habits in the school environment, awareness of the problem, meal planning, talking about the issue and the search for solutions.Conclusions: Parents encounter obstacles that hinder change and improvement in this population. Thus, it is necessary to address obesity and overweight as a multifactorial problem.
Published: 2022

22. Measuring Vitamin D-3 Metabolic Status, Comparison between Vitamin D Deficient and Sufficient Individuals

Author: Laura de los Santos Castillo-Peinado, Mónica Calderón-Santiago, Aura Dulcinea Herrera-Martínez, Soraya León-Idougourram, María Ángeles Gálvez-Moreno, Rafael Luis Sánchez-Cano, Roger Bouillon, Jose Manuel Quesada-Gómez, Feliciano Priego-Capote, [Laura de Los Santos Castillo-Peinado] Univ Cordoba, Dept Analyt Chem, Annex Marie Curie Bldg,Campus Rabanales, Cordoba 14014, Spain, [Calderon-Santiago, Monica] Univ Cordoba, Dept Analyt Chem, Annex Marie Curie Bldg,Campus Rabanales, Cordoba 14014, Spain, [Priego-Capote, Feliciano] Univ Cordoba, Dept Analyt Chem, Annex Marie Curie Bldg,Campus Rabanales, Cordoba 14014, Spain, [Laura de Los Santos Castillo-Peinado] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Inst Biomed Res IMIBIC, Cordoba 14014, Spain, [Calderon-Santiago, Monica] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Inst Biomed Res IMIBIC, Cordoba 14014, Spain, [Dulcinea Herrera-Martinez, Aura] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Inst Biomed Res IMIBIC, Cordoba 14014, Spain, [Leon-Idougourram, Soraya] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Inst Biomed Res IMIBIC, Cordoba 14014, Spain, [Angeles Galvez-Moreno, Maria] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Inst Biomed Res IMIBIC, Cordoba 14014, Spain, [Luis Sanchez-Cano, Rafael] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Inst Biomed Res IMIBIC, Cordoba 14014, Spain, [Manuel Quesada-Gomez, Jose] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Inst Biomed Res IMIBIC, Cordoba 14014, Spain, [Priego-Capote, Feliciano] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Inst Biomed Res IMIBIC, Cordoba 14014, Spain, [Laura de Los Santos Castillo-Peinado] Univ Cordoba, Nanochem Univ Inst IUNAN, Campus Rabanales, Cordoba 14014, Spain, [Calderon-Santiago, Monica] Univ Cordoba, Nanochem Univ Inst IUNAN, Campus Rabanales, Cordoba 14014, Spain, [Priego-Capote, Feliciano] Univ Cordoba, Nanochem Univ Inst IUNAN, Campus Rabanales, Cordoba 14014, Spain, [Laura de Los Santos Castillo-Peinado] Inst Salud Carlos III, CIBER Fragilidad & Envejecimiento Saludable CIBER, Madrid 28002, Spain, [Calderon-Santiago, Monica] Inst Salud Carlos III, CIBER Fragilidad & Envejecimiento Saludable CIBER, Madrid 28002, Spain, [Manuel Quesada-Gomez, Jose] Inst Salud Carlos III, CIBER Fragilidad & Envejecimiento Saludable CIBER, Madrid 28002, Spain, [Priego-Capote, Feliciano] Inst Salud Carlos III, CIBER Fragilidad & Envejecimiento Saludable CIBER, Madrid 28002, Spain, [Dulcinea Herrera-Martinez, Aura] Reina Sofia Univ Hosp, Endocrinol & Nutr Unit, Cordoba 14004, Spain, [Leon-Idougourram, Soraya] Reina Sofia Univ Hosp, Endocrinol & Nutr Unit, Cordoba 14004, Spain, [Angeles Galvez-Moreno, Maria] Reina Sofia Univ Hosp, Endocrinol & Nutr Unit, Cordoba 14004, Spain, [Luis Sanchez-Cano, Rafael] Reina Sofia Univ Hosp, Occupat Hlth Unit, Cordoba 14004, Spain, [Bouillon, Roger] Katholic Leuven Univ, Dept Chron Dis & Metab, Clin & Expt Endocrinol, B-3000 Leuven, Belgium, Spanish Ministerio de Ciencia e Innovacion, Junta de Andalucia, and European Regional Development Fund/European Social Fund ('Investing in your future')
Subjects: Serum, Science & Technology, vitamin D deficiency, Chemistry, Analytical, SPE–LC–MS/MS, 1,24,25-trihydroxyvitamin D-3, Sample preparation, Filtration and Separation, 1,25-dihydroxyvitamin D-3, Analytical Chemistry, Chemistry, 1,25‐dihydroxyvitamin D3, vitamin D-3, Physical Sciences, 24,25‐dihydroxyvitamin D3, vitamin D3, 1,25-dihydroxyvitamin D3, 24,25-dihydroxyvitamin D3, 1,24,25-trihydroxyvitamin D3, plasma, 24,25-dihydroxyvitamin D-3, SPE-LC-MS/MS, 25-hydroxyvitamin d-3, Ratio, Vitamin D3, 1,24,25‐trihydroxyvitamin D3
Abstract: The main branch of vitamin D-3 metabolism involves several hydroxylation reactions to obtain mono-, di- and trihydroxylated metabolites, including the circulating and active forms-25(OH)D-3 and 1,25(OH)(2)D-3, respectively. However, most clinical trials strictly target the determination of 25(OH)D-3 to offer a view of the metabolic status of vitamin D-3. Due to the growing interest in expanding this restricted view, we have developed a method for measuring vitamin D-3 metabolism by determination of vitamin D-3, 25(OH)D-3, 24,25(OH)(2)D-3, 1,25(OH)(2)D-3 and 1,24,25(OH)(3)D-3 in human plasma. The method was based on SPE-LC-MS/MS with a large volume injection of human plasma (240 mu L). Detection of di- and trihydroxymetabolites, found at the picogram per milliliter level, was attained by the combined action of high preconcentration and clean-up effects. The method allows obtaining information about ratios such as the known vitamin D metabolite ratio (24,25(OH)(2)D-3/25(OH)D-3), which can provide complementary views of vitamin D-3 metabolic status. The method was applied to a cohort of obese patients and a reference cohort of healthy volunteers to find metabolic correlations between target analytes as well as differences as a function of vitamin D levels within and between cohorts.
Published: 2022

23. Differential inflammatory environment in patients with osteoporosis and type 2 diabetes mellitus

Author: Muñoz-Torres, M., Carazo-Gallego, A., Jiménez-López, José Carlos, Avilés-Pérez, M.D., Díaz-Arco, S., Lozano-Alonso, S., Lima Cabello, Elena, Alché Ramírez, Juan de Dios, Reyes-García, R., Morales-Santana, S., [Munoz-Torres, M.] Univ Granada, Fac Med, Dept Med, Granada, Spain, [Munoz-Torres, M.] Hosp Univ San Cecilio, Inst Invest Biosanitaria Granada IbsGRANADA, UGC Endocrinol & Nutr, Unidad Metabolismo Oseo, Granada, Spain, [Aviles-Perez, M. D.] Hosp Univ San Cecilio, Inst Invest Biosanitaria Granada IbsGRANADA, UGC Endocrinol & Nutr, Unidad Metabolismo Oseo, Granada, Spain, [Munoz-Torres, M.] Inst Salud Carlos III, Ctr Invest Biomed Red CIBER, Area Temat CIBER Fragilidad & Envejecimiento Salu, Madrid, Spain, [Aviles-Perez, M. D.] Inst Salud Carlos III, Ctr Invest Biomed Red CIBER, Area Temat CIBER Fragilidad & Envejecimiento Salu, Madrid, Spain, [Reyes-Garcia, R.] Inst Salud Carlos III, Ctr Invest Biomed Red CIBER, Area Temat CIBER Fragilidad & Envejecimiento Salu, Madrid, Spain, [Morales-Santana, S.] Inst Salud Carlos III, Ctr Invest Biomed Red CIBER, Area Temat CIBER Fragilidad & Envejecimiento Salu, Madrid, Spain, [Carazo-Gallego, A.] Hosp Univ San Cecilio, Inst Biosanitario Granada, Unidad Enfermedades Digest, Granada, Spain, [Jimenez-Lopez, J. C.] CSIC, Estn Expt Zaidin, Dept Bioquim Biol Celular & Mol Plantas, Granada, Spain, [Lima-Cabello, E.] CSIC, Estn Expt Zaidin, Dept Bioquim Biol Celular & Mol Plantas, Granada, Spain, [Alche, J. de Dios] CSIC, Estn Expt Zaidin, Dept Bioquim Biol Celular & Mol Plantas, Granada, Spain, [Jimenez-Lopez, J. C.] Univ Oeste Australia UWA, Inst Agr, Perth, WA, Australia, [Jimenez-Lopez, J. C.] Univ Oeste Australia UWA, Escuela Agr & Medioambiente, Perth, WA, Australia, [Diaz-Arco, S.] Univ Granada, Hosp Univ San Cecilio, Inst Invest Biosanitaria Granada IbsGRANADA, Granada, Spain, [Lozano-Alonso, S.] Hosp Univ San Cecilio, Serv Angiol & Cirugia Vasc, Granada, Spain, [Reyes-Garcia, R.] Hosp Univ Torrecardenas, Unidad Endocrinol & Nutr, Almeria, Spain, [Morales-Santana, S.] Hosp Univ San Cecilio, Serv Invest Proteom, Inst Invest Biosanitaria Granada IbsGranada, Granada, Spain, European Commission, Ministerio de Economía, Industria y Competitividad (España), Junta de Andalucía, Fundación Española de Investigación Ósea y del Metabolismo Mineral, and Sociedad Española de Endocrinología y Nutrición
Subjects: Markers, Alpha, Bone-mineral density, Inflamación, Fracture risk, Il-12, Citocinas, Interleukin-10, Older, Diabetes mellitus tipo 2, Osteoporosis, Cytokines, Insulin, Women
Abstract: Objetive: Type 2 diabetes mellitus (DM2) and osteoporosis are diseases associated with a pro‐inflammatory environment, the prevention of which through new therapeutic strategies could prevent their development. However, there are few studies that evaluate the inflammatory profile of osteoporosis in patients with DM2. This study focuses on evaluating the inflammatory immune response through serum concentrations of nine cytokines, two of them anti‐inflammatory (IL‐10, IL‐5) and six pro‐inflammatory (IL‐2, IL‐6, IL‐12 (p70), IL‐17A, TNFα and IFNγ) in 163 individuals with DM2 and 47 controls. A subpopulation, made up of 43 DM2 patients without osteoporosis, and 33 with osteoporosis, was analyzed in greater depth at the level of bone parameters. Furthermore, we have assessed the calciotropic hormones, bone remodeling markers, bone mineral density and vertebral fractures in the population, and we have analyzed the relationship of the cytokines tested with DM2, osteoporosis and prevalent vertebral fractures. Patients with DM2 had significantly higher serum concentrations of IL‐10 compared to the control group (0.5±1 vs. 0.14±0.3 pg/ml; p=0.016) and the levels of IL12 p70 were shown lower in patients with DM2 compared to controls (2.9±1.6 vs. 3.9±3.1 pg/ml; p=0.027). In the group of patients with DM2 and osteoporosis, the levels of the cytokine IL‐6 were elevated compared to the group with DM2 without osteoporosis (10.9±14.6 vs. 4.5±7.0; p=0.017). An association of IL‐5 was also observed, with its lowest levels in the DM2 group with osteoporosis (1.7±0.2 vs. 3.8±0.6; p=0.032). Furthermore, IL‐5 showed a direct correlation with the levels of the bone formation biomarker alkaline bone phosphatase (r=0.277, p=0.004) in the subpopulation of patients with DM2. The rest of cytokines did not show significant differences. In conclusion, our findings indicate that in our study population, patients with DM2 compared to healthy subjects present an inflammatory profile opposite to what is expected in a hyperglycemic situation, probably as a compensatory response to the inflammation caused. The cytokine profile is modified in the subpopulation of diabetic patients, depending on the presence of osteoporosis. In this case, the inflammatory profile in the presence of osteoporosis is consistent with the expected response., Este estudio ha sido financiado con las ayudas para realización de proyectos otorgadas por las fundaciones FEIOMM y SEEN, así como por el proyecto de la Consejería de Salud y familias PI-0450-2019. Además, el Dr. Jiménez-López agradece la financiación al programa de investigación Europeo Marie Curie (FP7--PEOPLE-2011-IOF, número de referencia PIOF-GA-2011-301550), así como al Ministerio de Economía, Industria y Competitividad por el proyecto del programa Ramón y Cajal (RYC-2014-16536) y el proyecto BFU2016-77243-P.
Published: 2022

24. 25-OH-vitamin D and reversal of metabolic comorbidities associated with obesity after bariatric surgery

Author: Leon, S., Laguna M, Alcantara, Puerta, Molina M. J., Morenos, Galvez M. A., Herrera-Martinez, A. D., [Leon, S.] Hosp Univ Reina Sofia, Serv Endocrinol & Nutr, Cordoba, Spain, [Laguna M, Alcantara] Hosp Univ Reina Sofia, Serv Endocrinol & Nutr, Cordoba, Spain, [Puerta, Molina M. J.] Hosp Univ Reina Sofia, Serv Endocrinol & Nutr, Cordoba, Spain, [Morenos, Galvez M. A.] Hosp Univ Reina Sofia, Serv Endocrinol & Nutr, Cordoba, Spain, [Herrera-Martinez, A. D.] Hosp Univ Reina Sofia, Serv Endocrinol & Nutr, Cordoba, Spain, [Leon, S.] Inst Maimonides Invest Biomed Cordoba, Cordoba, Spain, [Laguna M, Alcantara] Inst Maimonides Invest Biomed Cordoba, Cordoba, Spain, [Puerta, Molina M. J.] Inst Maimonides Invest Biomed Cordoba, Cordoba, Spain, [Morenos, Galvez M. A.] Inst Maimonides Invest Biomed Cordoba, Cordoba, Spain, and [Herrera-Martinez, A. D.] Inst Maimonides Invest Biomed Cordoba, Cordoba, Spain
Subjects: Risk, Vitamin-d, Disease, Gastric bypass-surgery, Guidelines, Mortality, Sleeve-gastrectomy, Prevent
Published: 2022

25. Acondroplasia: actualización en diagnóstico, seguimiento y tratamiento

Author: Antonio Leiva-Gea, María F. Martos Lirio, Ana Coral Barreda Bonis, Silvia Marín del Barrio, Karen E. Heath, Purificacion Marín Reina, Encarna Guillén-Navarro, Fernando Santos Simarro, Isolina Riaño Galán, Diego Yeste Fernández, Isabel Leiva-Gea, Institut Català de la Salut, [Leiva-Gea A] UGC Cirugía Ortopédica y Traumatología, Hospital Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA)-Plataforma Bionand, Málaga, Spain. [Martos Lirio MF] Unidad de Endocrinología Pediátrica, Hospital Regional de Málaga, Málaga, Spain. [Barreda Bonis AC] Servicio de Endorinología Infantil y Unidad multidisciplinar de displasias esqueléticas (UMDE)-ERN BOND, Hospital Universitario La Paz, Madrid, Spain. [Marín Del Barrio S] Unidad de Endocrinología Pediátrica, Hospital San Joan de Déu, Barcelona, Spain. [Heath KE] Instituto de Genética Médica y Molecular (INGEMM), IdiPAZ y UMDE-ERN BOND, Hospital Universitario La Paz, Madrid, Spain. [Marín Reina P] Unidad de Dismorfología y Genética Reproductiva, Hospital Universitario y Politécnico La Fe, Valencia, Spain. [Yeste Fernández D] Unitat d’Endocrinologia Pediàtrica, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus, [Leiva-Gea, Antonio] Hosp Univ Virgen Victoria, UGC Cirugia Ortoped & Traumatol, Inst Invest Biomed Malaga IBIMA Plataforma Bionand, Malaga, Spain, [Leiva-Gea, Isabel] Hosp Univ Virgen Victoria, UGC Cirugia Ortoped & Traumatol, Inst Invest Biomed Malaga IBIMA Plataforma Bionand, Malaga, Spain, [Lirio, Maria F. Martos] Hosp Reg Malaga, Unidad Endocrinol Pediat, Malaga, Spain, [Bonis, Ana Coral Barreda] Hosp Univ La Paz, Serv Endorinol Infantil, Madrid, Spain, [Bonis, Ana Coral Barreda] Hosp Univ La Paz, Unidad multidisciplinar displasias esquelet UMDE E, Madrid, Spain, [del Barrio, Silvia Marin] Hosp San Joan de Deu, Unidad Endocrinol Pediat, Barcelona, Spain, [Heath, Karen E.] Hosp Univ La Paz, Inst Genet Med & Mol INGEMM, IdiPAZ & UMDE ERN BOND, Madrid, Spain, [Fernandez, Diego Yeste] Hosp Univ La Paz, Inst Genet Med & Mol INGEMM, IdiPAZ & UMDE ERN BOND, Madrid, Spain, [Lirio, Maria F. Martos] Hosp Univ & Politecn La Fe, Unidad Dismorfol & Genet Reprod, Valencia, Spain, [Guillen-Navarro, Encarna] Univ Murcia, Serv Genet Med, Serv Pediat, IMIB Pascual Parrilla,Hosp Clin Univ Virgen Arrixa, Murcia, Spain, [Simarro, Fernando Santos] Hosp Univ Son Espases, Unidad Diagnost Mol & Genet Clin, Idisba, Palma De Mallorca, Spain, [Galan, Isolina Riano] Hosp Reg Malaga, Unidad Endocrinol Pediat, Inst Invest Biomed Malaga Plataforma Bionand, HUCA,CIBERESP, Malaga, Spain, [Fernandez, Diego Yeste] Univ Autonoma Barcelona, Hosp Univ Vall Hebron, Serv Endocrinol Pediat, Barcelona, Spain, and [Leiva-Gea, Isabel] Hosp Reg Malaga, Inst Invest Biomed Malaga Plataforma Bionand, Unidad Endocrinol Pediat, Malaga, Spain
Subjects: Acondroplàsia - Tractament, Growth, Other subheadings::/therapy [Other subheadings], personas::Grupos de Edad::niño [DENOMINACIONES DE GRUPOS], Persons::Age Groups::Child [NAMED GROUPS], Charts, Achondroplasia, Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Health Status::Quality of Life [HEALTH CARE], Bone dysplasia, FGFR3, Qualitat de vida, enfermedades musculoesqueléticas::enfermedades óseas::enfermedades óseas del desarrollo::enanismo::acondroplasia [ENFERMEDADES], Management of Technology and Innovation, Children, Infants, Otros calificadores::/terapia [Otros calificadores], Musculoskeletal Diseases::Bone Diseases::Bone Diseases, Developmental::Dwarfism::Achondroplasia [DISEASES], ambiente y salud pública::salud pública::medidas epidemiológicas::demografía::estado de salud::calidad de vida [ATENCIÓN DE SALUD]
Abstract: Achondroplasia; Bone dysplasia Acondroplasia; Displasia ósea Acondroplàsia; Displàsia òssia Achondroplasia requieres multidisciplinary follow-up, with the aim of preventing and managing complications, improving the quality of life of people who suffer from it and favoring their independence and social inclusion. This review is justified by the multiple publications generated in recent years that have carried out a change in its management. Different guidelines and recommendations have been developed, among which the one made by the American Academy of Pediatrics in 2005 recently updated (2020), the Japanese guide (2020), the first European Consensus (2021) and the International Consensus on the diagnosis, approach multidisciplinary approach and management of individuals with achondroplasia throughout life (2021). However, and despite these recommendations, there is currently a great worldwide variability in the management of people with achondroplasia, with medical, functional and psychosocial consequences in patients and their families. Therefore, it is essential to integrate these recommendations into daily clinical practice, taking into account the particular situation of each health system. La acondroplasia requiere un seguimiento multidisciplinario, con el objetivo de prevenir y manejar las complicaciones, mejorar la calidad de vida de las personas que la padecen y favorecer su independencia e inclusión social. Esta revisión se justifica por las múltiples publicaciones generadas en los últimos años que han llevado a cabo un cambio en su gestión. Se han desarrollado diferentes guías y recomendaciones, entre las que destacan la realizada por la Academia Americana de Pediatría en 2005 recientemente actualizada (2020), la guía japonesa (2020), el primer Consenso Europeo (2021) y el Consenso Internacional sobre el diagnóstico, abordaje, enfoque multidisciplinario y manejo de individuos con acondroplasia a lo largo de la vida (2021). Sin embargo, y a pesar de estas recomendaciones, actualmente existe una gran variabilidad a nivel mundial en el manejo de las personas con acondroplasia, con consecuencias médicas, funcionales y psicosociales en los pacientes y sus familias. Por ello, es fundamental integrar estas recomendaciones en la práctica clínica diaria, teniendo en cuenta la situación particular de cada sistema sanitario.
Published: 2022
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26. Obesity and COVID-19. A necessary position statement

Author: Breton, Irene, de Hollanda, Ana, Vilarrasa, Nuria, Herrera, Miguel A. Rubio, Lecube, Albert, Salvador, Javier, Garcia-Luna, Pedro Pablo, Tinahones, Francisco J., Santos, Raquel Sanchez, Huelgas, Ricardo Gomez, Gomez, Juana Carretero, Moize, Violeta, Garcia, Jose Polo, Iparraguirre, Salvador Tranche, Ledesma, Antonio Fernandez -Pro, Escalada, Javier, SEEN, SEEDO, SEMI, SEDYN, SEMERGEN, [Breton, Irene] Univ Complutense, Soc Espanola Endocrinol & Nutr SEEN, Hosp Univ Gregorio Maranon, Serv Endocrinol & Nutr,IiSGM,Fac Med, Madrid, Spain, [de Hollanda, Ana] Barcelona Inst Invest Biomed August Pi i Sunyer I, Soc Espanola Endocrinol & Nutr SEEN, Coordinadora Electa GOSEEN, Hosp Clin,Serv Endocrinol Nutr, Barcelona, Spain, [Vilarrasa, Nuria] Hosp Univ Bellvitge IDIBELL, Soc Espanola Endocrinol & Nutr SEEN, CIBERDEM, Coordinadora GOSEEN,Serv Endocrinol & Nutr, Barcelona, Spain, [Herrera, Miguel A. Rubio] Univ Complutense, Soc Espanola Endocrinol & Nutr SEEN, Hosp Clin San Carlos, Serv Endocrinol & Nutr,IDISSC,Fac Med, Madrid, Spain, [Lecube, Albert] Univ Lleida UdL, Soc Espanola Endocrinol & Nutr SEEN, CIBERDEM,Inst Rec Biomed Lleida IRBLleida, Hosp Univ Arnau Vilanova Lleida,Grp Obesidad,SEED, Lleida, Spain, [Salvador, Javier] Univ Navarra, Endocrinol, Pamplona, Spain, [Salvador, Javier] Inst Carlos III, Soc Espanola Endocrinol & Nutr SEEN, CIBEROBN, Madrid, Spain, [Garcia-Luna, Pedro Pablo] Hosp Univ Virgen Rocio, Soc Espanola Endocrinol & Nutr SEEN, UGEN, Unidad Nutr, Seville, Spain, [Tinahones, Francisco J.] Univ Malaga, Soc Espanola Endocrinol & Nutr SEEN, Hosp Virgen Victoria Malaga, CIBEROBN,Serv Endocrinol & Nutr, Malaga, Spain, [Santos, Raquel Sanchez] Complejo Hosp Univ Vigo, Inst Invest Galicia Sur, Soc Espanola Cirugia Obesidad SECO, Galicia, Spain, [Huelgas, Ricardo Gomez] Univ Malaga, Hosp Reg Univ Malaga, Soc Espanola Med Interna SEMI, Serv Med Interna,Inst Invest Biomed Malaga IBIMA, Malaga, Spain, [Gomez, Juana Carretero] Hosp Comarcal Zafra, Soc Espanola Med Interna SEMI, Serv Med Interna, Badajoz, Spain, [Moize, Violeta] Hosp Clin Barcelona, Soc Espanola Dietet & Nutr SEDYN, Unidad Func Obesidad, Barcelona, Spain, [Garcia, Jose Polo] Soc Espanola Med Atenc Primaria SEMERGEN, Ctr Salud Casar Caceres, Caceres, Spain, [Iparraguirre, Salvador Tranche] Soc Espanola Med Familiar & Comunitaria semFYC, Serv Salud Principado Asturias SESPA, Ctr Salud El Cristo, Oviedo, Asturias, Spain, [Ledesma, Antonio Fernandez -Pro] Soc Espanola Med Gen SEMG, Ctr Salud Menasalbas, Toledo, Spain, and [Escalada, Javier] Clin Univ Navarra, Soc Espanola Endocrinol & Nutr SEEN, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Dept Endocrinol & Nutr,ISCIII,Grp Nefrol Clin,Ins, Navarra, Spain
Published: 2021

27. Comparison of the Performance of Second (Fast TSH) and Third (HYPERsensitive TSH) Generation Automated TSH Immunoassays in Healthy Euthyroid Subjects

Author: Dilek Berker, Turan Turhan, Fatma Saglam, Halef Okan Doğan, Esin Calci, and [Calci, Esin] Usak Publ Hlth Lab, Dept Biochem, Usak, Turkey -- [Dogan, Halef Okan] Cumhuriyet Univ, Dept Biochem, Fac Med, Sivas, Turkey -- [Saglam, Fatma] Etimed Hosp, Dept Endocrinol, Ankara, Turkey -- [Turhan, Turan] Ankara Numune Training & Res Hosp, Dept Biochem, Ankara, Turkey -- [Berker, Dilek] Ankara Numune Training & Res Hosp, Dept Endocrinol, Ankara, Turkey
Subjects: medicine.medical_specialty, Fast TSH, endocrine system, lcsh:R5-920, endocrine system diseases, business.industry, HYPERsensitive TSH, Endocrinology, method comparison, Internal medicine, generation, medicine, Euthyroid, hypersensitive tsh, fast tsh, business, lcsh:Medicine (General), hormones, hormone substitutes, and hormone antagonists
Abstract: WOS: 000462172800010, Objective: We aimed to compare the performances of HYPERsensitive and Fast thyroid-stimulating hormone (TSH) methods in euthyroid subjects. Materials and Methods: The study included 500 euthyroid subjects. We measured the TSH levels of study subjects using HYPERsensitive and Fast TSH methods. We compared the performances of the two methods. Moreover, free triiodothyronine and thyroxine, anti-thyroglobulin, and anti-thyroperoxidase levels were determined in study subjects. Results: Mean serum TSH levels were determined as 1.76 +/- 1.06 and 1.85 +/- 1.12 mu IU/mL using Fast and HYPERsensitive TSH methods, respectively. Differences were statistically significant (p
Published: 2019

28. U.S. Food and Drug Administration's Decision Regarding Bioequivalence of Levothyroxine Sodium

Author: Association, American Thyroid, Society, The Endocrine, and Endocrinol, American Association of Clinical
Published: 2004
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29. Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)

Author: Iurilli, Maria L. C., Zhou, Bin, Bennett, James E., Carrillo-Larco, Rodrigo M., Sophiea, Marisa K., Rodriguez-Martinez, Andrea, Bixby, Honor, Solomon, Bethlehem D., Taddei, Cristina, Danaei, Goodarz, Di Cesare, Mariachiara, Stevens, Gretchen A., Riley, Leanne M., Savin, Stefan, Cowan, Melanie J., Bovet, Pascal, Damasceno, Albertino, Chirita-Emandi, Adela, Hayes, Alison J., Ikeda, Nayu, Jackson, Rod T., Khang, Young-Ho, Laxmaiah, Avula, Liu, Jing, Miranda, J. Jaime, Saidi, Olfa, Sebert, Sylvain, Soric, Maroje, Starc, Gregor, Gregg, Edward W., Abarca-Gomez, Leandra, Abdeen, Ziad A., Abdrakhmanova, Shynar, Ghaffar, Suhaila Abdul, Rahim, Hanan F. Abdul, Abu-Rmeileh, Niveen M., Garba, Jamila Abubakar, Acosta-Cazares, Benjamin, Adams, Robert J., Aekplakorn, Wichai, Afsana, Kaosar, Afzal, Shoaib, Agdeppa, Imelda A., Aghazadeh-Attari, Javad, Aguilar-Salinas, Carlos A., Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmad, Noor Ani, Ahmadi, Ali, Ahmadi, Naser, Ahmed, Soheir H., Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M., Al-Lahou, Badreya, Al-Raddadi, Rajaa, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Ali, Mohamed M., Alkandari, Abdullah, Alkerwi, Ala'a, Allin, Kristine, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N., Amiri, Parisa, Amougou, Norbert, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A., Angquist, Lars, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Aounallah-Skhiri, Hajer, Araujo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E., Arlappa, Nimmathota, Aryal, Krishna K., Aspelund, Thor, Assah, Felix K., Assuncao, Maria Cecilia F., Aung, May Soe, Auvinen, Juha, Avdicova, Maria, Avi, Shina, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Azmin, Mehrdad, Babu, Bontha, Jorgensen, Maja Boksgaard, Baharudin, Azli, Bahijri, Suhad, Baker, Jennifer L., Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Bandosz, Piotr, Banegas, Jose R., Baran, Joanna, Barbagallo, Carlo M., Barcelo, Alberto, Barkat, Amina, Barros, Aluisio Jd, Gomes Barros, Mauro Virgilio, Basit, Abdul, Bastos, Joao Luiz D., Bata, Iqbal, Batieha, Anwar M., Batista, Rosangela L., Battakova, Zhamilya, Batyrbek, Assembekov, Baur, Louise A., Beaglehole, Robert, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedics, Judith, Benet, Mikhail, Bergh, Ingunn Holden, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Bettiol, Heloisa, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K., Bhutta, Zulfiqar A., Bi, Hongsheng, Bi, Yufang, Bia, Daniel, Lele, Elysee Claude Bika, Bikbov, Mukharram M., Bista, Bihungum, Bjelica, Dusko J., Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B., Bjorkelund, Cecilia, Bloch, Katia, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boddy, Lynne M., Boehm, Bernhard O., Boeing, Heiner, Boggia, Jose G., Bogova, Elena, Boissonnet, Carlos P., Bojesen, Stig E., Bonaccio, Marialaura, Bongard, Vanina, Bonilla-Vargas, Alice, Bopp, Matthias, Borghs, Herman, Braeckevelt, Lien, Braeckman, Lutgart, Bragt, Marjolijn C. E., Brajkovich, Imperia, Branca, Francesco, Breckenkamp, Juergen, Breda, Joao, Brenner, Hermann, Brewster, Lizzy M., Brian, Garry R., Brinduse, Lacramioara, Brophy, Sinead, Bruno, Graziella, Bueno-de-Mesquita, H. Bas, Bugge, Anna, Buoncristiano, Marta, Burazeri, Genc, Burns, Con, Cabrera de Leon, Antonio, Cacciottolo, Joseph, Cai, Hui, Cama, Tilema, Cameron, Christine, Camolas, Jose, Can, Gunay, Candido, Ana Paula C., Canete, Felicia, Capanzana, Mario, Capkova, Nadezda, Capuano, Eduardo, Capuano, Vincenzo, Cardol, Marloes, Cardoso, Viviane C., Carlsson, Axel C., Carmuega, Esteban, Carvalho, Joana, Casajus, Jose A., Casanueva, Felipe F., Celikcan, Ertugrul, Censi, Laura, Cervantes-Loaiza, Marvin, Cesar, Juraci A., Chamukuttan, Snehalatha, Chan, Angelique W., Chan, Queenie, Chaturvedi, Himanshu K., Chaturvedi, Nish, Rahim, Norsyamlina Che Abdul, Chee, Miao Li, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Shuohua, Chen, Zhengming, Cheng, Ching-Yu, Cheraghian, Bahman, Chetrit, Angela, Chikova-Iscener, Ekaterina, Chiolero, Arnaud, Chiou, Shu-Ti, Chirlaque, Maria-Dolores, Cho, Belong, Christensen, Kaare, Christofaro, Diego G. [UNESP], Chudek, Jerzy, Cifkova, Renata, Cilia, Michelle, Cinteza, Eliza, Claessens, Frank, Clarke, Janine, Clays, Els, Cohen, Emmanuel, Concin, Hans, Confortin, Susana C., Cooper, Cyrus, Coppinger, Tara C., Corpeleijn, Eva, Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L., Crampin, Amelia C., Crujeiras, Ana B., Csilla, Semanova, Cucu, Alexandra M., Cui, Liufu, Cureau, Felipe, Czenczek-Lewandowska, Ewelina, D'Arrigo, Graziella, D'Orsi, Eleonora, Dacica, Liliana, Dal Re Saavedra, Maria Angeles, Dallongeville, Jean, Damsgaard, Camilla T., Dankner, Rachel, Dantoft, Thomas M., Dasgupta, Parasmani, Dastgiri, Saeed, Dauchet, Luc, Davletov, Kairat, De Backer, Guy, De Bacquer, Dirk, Gaetano, Giovanni de, De Henauw, Stefaan, Oliveira, Paula Duarte de, De Ridder, David, De Ridder, Karin, Rooij, Susanne R. de, De Smedt, Delphine, Deepa, Mohan, Deev, Alexander D., DeGennaro, Vincent, Dehghan, Abbas, Delisle, Helene, Delpeuch, Francis, Demarest, Stefaan, Dennison, Elaine, Deren, Katarzyna, Deschamps, Valerie, Dhimal, Meghnath, Di Castelnuovo, Augusto F., Dias-da-Costa, Juvenal Soares, Diaz-Sanchez, Maria Elena, Diaz, Alejandro, Dika, Zivka, Djalalinia, Shirin, Djordjic, Visnja, Do, Ha T. P., Dobson, Annette J., Donati, Maria Benedetta, Donfrancesco, Chiara, Donoso, Silvana P., Doring, Angela, Dorobantu, Maria, Dorosty, Ahmad Reza, Doua, Kouamelan, Dragano, Nico, Drygas, Wojciech, Duan, Jia Li, Duante, Charmaine A., Duboz, Priscilla, Duda, Rosemary B., Duleva, Vesselka, Dulskiene, Virginija, Dumith, Samuel C., Dushpanova, Anar, Dzerve, Vilnis, Dziankowska-Zaborszczyk, Elzbieta, Eddie, Ricky, Eftekhar, Ebrahim, Egbagbe, Eruke E., Eggertsen, Robert, Eghtesad, Sareh, Eiben, Gabriele, Ekelund, Ulf, El-Khateeb, Mohammad, El Ati, Jalila, Eldemire-Shearer, Denise, Eliasen, Marie, Elliott, Paul, Engle-Stone, Reina, Enguerran, Macia, Erasmus, Rajiv T., Erbel, Raimund, Erem, Cihangir, Eriksen, Louise, Eriksson, Johan G., Escobedo-de la Pena, Jorge, Eslami, Saeid, Esmaeili, Ali, Evans, Alun, Faeh, David, Fakhretdinova, Albina A., Fall, Caroline H., Faramarzi, Elnaz, Farjam, Mojtaba, Sant'Angelo, Victoria Farrugia, Farzadfar, Farshad, Fattahi, Mohammad Reza, Fawwad, Asher, Felix-Redondo, Francisco J., Ferguson, Trevor S., Fernandes, Romulo A. 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T., Uysal, Nalan, Vaitkeviciute, Justina, Valdivia, Gonzalo, Vale, Susana, Valvi, Damaskini, van Dam, Rob M., Van der Heyden, Johan, van der Schouw, Yvonne T., Van Herck, Koen, Van Minh, Hoang, Van Schoor, Natasja M., van Valkengoed, Irene G. M., Vanderschueren, Dirk, Vanuzzo, Diego, Varbo, Anette, Varela-Moreiras, Gregorio, Varona-Perez, Patricia, Vasan, Senthil K., Vega, Tomas, Veidebaum, Toomas, Velasquez-Melendez, Gustavo, Velika, Biruta, Veronesi, Giovanni, Verschuren, W. M. Monique, Victora, Cesar G., Viegi, Giovanni, Viet, Lucie, Villalpando, Salvador, Vineis, Paolo, Vioque, Jesus, Virtanen, Jyrki K., Visser, Marjolein, Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vladulescu, Mihaela, Vlasoff, Tiina, Vocanec, Dorja, Vollenweider, Peter, Volzke, Henry, Voutilainen, Ari, Voutilainen, Sari, Vrijheid, Martine, Vrijkotte, Tanja G. M., Wade, Alisha N., Wagner, Aline, Medical, Thomas Waldhor, Walton, Janette, Wambiya, Elvis O. A., Bebakar, Wan Mohamad Wan, Mohamud, Wan Nazaimoon Wan, Junior, Rildo de Souza Wanderley, Wang, Ming-Dong, Wang, Ningli, Wang, Qian, Wang, Xiangjun, Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S. 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Puerto Rico, Ctr Clin Res & Prevent, MRC Lifecourse Epidemiol Unit, Kwame Nkrumah Univ Sci & Technol, UniSante, Inst Canc Res, Univ Wisconsin, Heidelberg Univ, IRCCS Ente Osped Specializzato Gastroenterol S de, Zayed Univ, Catholic Univ Daegu, Univ Med Pharm Sci & Technol Targu Mures, Jivandeep Hosp, Natl Dent Care Ctr Singapore, Univ Malaga, Univ Hosp Varese, Vietnam Natl Heart Inst, Clin Med Avanzada Dr Abel Gonzalez, Leibniz Inst Prevent Res & Epidemiol BIPS, Univ Sarajevo, Cardiovasc Prevent Ctr Udine, Pisa Univ Hosp, Publ Hlth Agcy Catalonia, Inst Hosp del Mar Invest Med, Ardabil Univ Med Sci, Ctr Dis Prevent & Control, Alborz Univ Med Sci, Pure Earth, Inst Epidemiol Dis Control & Res, Univ Turku, Inst Univ Invest Atenc Primaria Jordi Gol, Univ Putra Malaysia, Univ Malaya, Sotiria Hosp, Univ Valencia, Univ Philippines, Slovak Acad Sci, Nutr Res Fdn, Minas Gerais State Secretariat Hlth, CS S Agustin Ibsalut, Amsterdam Inst Global Hlth & Dev, Natl Inst Hlth Doutor Ricardo Jorge, Univ Nove Julho, Publ Hlth Agcy Canada, Canarian Hlth Serv, Univ Ind Santander, Assoc Calabrese Epatol, Univ Minho, Fiji Natl Univ, Spanish Nutr Fdn, Publ Hlth Agcy Sweden, Inst Food Sci Natl Res Council, Sitaram Bhartia Inst Sci & Res, Kindergarten Avlonari, Natl Inst Hlth, Catalan Dept Hlth, Biodonostia Hlth Res Inst, Inst Saude Ambiental, South Karelia Social & Hlth Care Dist, McMaster Univ, Hosp Italiano Buenos Aires, Rigshosp, Acad Med Ctr Univ Amsterdam, Ctr Oral Hlth Serv & Res Midnorway, Lagos State Univ, Univ Las Palmas Gran Canaria, Comenius Univ, Natl Ctr Dis Control & Publ Hlth, Nippon Med Sch, Sungkyunkwan Univ, Finnish Inst Occupat Hlth, Publ Hlth Promot & Dev Org, St Vincents Hosp, Nes Municipal, Hlth Polytech Jakarta II Inst, Diponegoro Univ, Univ Bari, Inst Reg Sante Publ, Univ Bordeaux, Oslo Metropolitan Univ, Univ Leuven, Lamprecht & Stamm Sozialforsch & Beratung AG, Univ Bonn, Kalina Malina Kindergarten, Jikei Univ, Fu Jen Catholic Univ, Natl Stat Off, Natl Inst Publ Hlth Natl Inst Hyg, Sci Res Inst Maternal & Child Hlth, Univ Lincoln, Cent Univ Kerala, Amsterdam Publ Hlth Res Inst, Hlth Serv Murcia, Inst Invest Sanitaria Illes Balears, Univ Bologna, Hellen Hlth Fdn, Govt Med Coll, Sefako Makgatho Hlth Sci Univ, Addis Ababa Univ, Univ Ctr Occidental Lisandro Alvarado, Meharry Med Coll, Dokuz Eylul Univ, Univ Tampere, Sabiha Gokcen Ilkokulu, Polytech Inst Porto, Icahn Sch Med Mt Sinai, Univ CEU San Pablo, Univ Miguel Hernandez, Vrije Univ Amsterdam, Sunflower Nursery Sch, North Karelia Ctr Publ Hlth, Univ Witwatersrand, Med Univ Vienna, Cork Inst Technol, Inst Med Res, Xinjiang Med Univ, Shanghai Educ Dev Co Ltd, Rebro Univ, St Georges Univ London, Univ Indonesia, Minist Agr & Rural Affairs, Fudan Univ, Univ Cyprus, Niigata Univ, Int Med Univ, Iran Univ Med Sci, Ctr Diabet & Endocrine Care, Peking Univ First Hosp, Jiangsu Prov Ctr Dis Control & Prevent, Sun Yat Sen Univ, West Kazakhstan Med Univ, Inner Mongolia Med Univ, and Przedszkole 81
Subjects: Life Sciences & Biomedicine - Other Topics, Science & Technology, AUSTRALIAN ADULTS, CHINESE ADULTS, nutritional and metabolic diseases, MALNUTRITION, TRENDS, DOUBLE BURDEN, PREVALENCE, POOLED ANALYSIS, US ADULTS, SYSTEMATIC ANALYSIS, HEALTH, sense organs, skin and connective tissue diseases, Life Sciences & Biomedicine, Biology
Abstract: Made available in DSpace on 2021-06-25T15:08:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-03-09 Wellcome Trust From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions. 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State Of Palest, Israel Usmanu Danfodiyo Univ Teaching Hosp, Sokoto, Nigeria Inst Mexicano Seguro Social, Mexico City, DF, Mexico Flinders Univ S Australia, Adelaide, SA, Australia Mahidol Univ, Salaya, Nakhon Pathom, Thailand BRAC James P Grant Sch Publ Hlth, Dhaka, Bangladesh Univ Copenhagen, Copenhagen, Denmark Copenhagen Univ Hosp, Copenhagen, Denmark Food & Nutr Res Inst, Taguig, Philippines Urmia Univ Med Sci, Orumiyeh, Iran Inst Nacl Ciencias Med & Nut, Mexico City, DF, Mexico Univ Amsterdam, Amsterdam, Netherlands Shahrekord Univ Med Sci, Shahrekord, Iran Noncommunicable Dis Res Ctr, Tehran, Iran Univ Oslo, Oslo, Norway Univ Bremen, Bremen, Germany Republican Ctr Hlth Promot, Bishkek, Kyrgyzstan Natl Ctr Diabet Endocrinol & Genet, Amman, Jordan Princess Nourah Bint Abdulrahman Univ, Riyadh, Saudi Arabia Kuwait Inst Sci Res, Kuwait, Kuwait King Abdulaziz Univ, Jeddah, Saudi Arabia Dasman Diabet Inst, Kuwait, Kuwait Luxembourg Inst Hlth, Strassen, Luxembourg Aldara Hosp & Med 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Bystrica, Slovakia Tel Aviv Univ, Tel Aviv, Israel Hebrew Univ Jerusalem, Jerusalem, Israel Univ Porto, Med Sch, Porto, Portugal Neyshabur Univ Med Sci, Neyshabur, Iran Res Inst Endocrine Sci, Tehran, Iran Indian Council Med Res, New Delhi, India Natl Inst Publ Hlth, Copenhagen, Denmark Univ Sci & Technol, Sanaa, Yemen Med Univ Lodz, Lodz, Poland Med Univ Gdansk, Gdansk, Poland Univ Autonoma Madrid CIBERESP, Madrid, Spain Univ Rzeszow, Rzeszow, Poland Univ Palermo, Palermo, Italy Pan Amer Hlth Org, Washington, DC USA Mohammed V Univ Rabat, Rabat, Morocco Univ Pernambuco, Recife, PE, Brazil Baqai Inst Diabetol & Endocrinol, Karachi, Pakistan Univ Fed Santa Catarina, Florianopolis, SC, Brazil Dalhousie Univ, Halifax, NS, Canada Jordan Univ Sci & Technol, Irbid, Jordan Univ Fed Maranhao, Sao Luis, Brazil Farabi Kazakh Natl Univ, Alma Ata, Kazakhstan Univ Coll Dublin, Dublin, Ireland Christian Med Coll & Hosp, Vellore, Tamil Nadu, India Fed Minist Social Affairs Hlth Care & Consumer Pr, Vienna, Austria Cafam Univ Fdn, Bogota, Colombia Kazakh Natl Med Univ, Alma Ata, Kazakhstan Lithuanian Univ Hlth Sci, Kaunas, Lithuania Univ Sao Paulo, Sao Paulo, Brazil BJ Med Coll, Ahmadabad, Gujarat, India Chirayu Med Coll, New Delhi, India Sunder Lal Jain Hosp, Delhi, India Hosp Sick Children, Toronto, ON, Canada Shandong Univ Tradit Chinese Med, Jinan, Peoples R China Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China Univ Republica, Montevideo, Uruguay Inst Med Res & Med Plant Studies, Yaounde, Cameroon Ufa Eye Res Inst, Ufa, Russia Nepal Hlth Res Council, Kathmandu, Nepal Univ Montenegro, Niksic, Montenegro Univ Southern Denmark, Copenhagen, Denmark Univ Gothenburg, Gothenburg, Sweden Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands Univ Turin, Turin, Italy UCL, London, England Liverpool John Moores Univ, Liverpool, Merseyside, England Nanyang Technol Univ Singapore, Singapore, Singapore German Inst Human Nutr, Potsdam, Germany Endocrinol Res Ctr, Moscow, Russia Ctr Educ Med & Invest Clin, Buenos Aires, DF, Argentina IRCCS Neuromed, Pozzilli, Italy Toulouse Univ, Sch Med, Toulouse, France Univ Zurich, Zurich, Switzerland Univ Hosp KU Leuven, Leuven, Belgium Flemish Agcy Care & Hlth, Brussels, Belgium Univ Ghent, Ghent, Belgium FrieslandCampina, Amersfoort, Netherlands Univ Cent Venezuela, Caracas, Venezuela Bielefeld Univ, Bielefeld, Germany World Hlth Org Reg Off Europe, Moscow, Russia German Canc Res Ctr, Heidelberg, Germany Fred Hollows Fdn, Auckland, New Zealand Univ Med & Pharm Bucharest, Bucharest, Romania Swansea Univ, Swansea, W Glam, Wales Univ Coll Copenhagen, Copenhagen, Denmark Inst Publ Hlth, Tirana, Albania Munster Technol Univ, Cork, Ireland Univ La Laguna, Tenerife, Spain Univ Malta, Msida, Malta Vanderbilt Univ, 221 Kirkland Hall, Nashville, TN 37235 USA Minist Hlth, Tongatapu, Tonga Canadian Fitness & Lifestyle Res Inst, Ottawa, ON, Canada Hosp Santa Maria, Lisbon, Portugal Istanbul Univ Cerrahpasa, Istanbul, Turkey Univ Fed Juiz de Fora, Juiz De Fora, Brazil Minist Publ Hlth, Asuncion, Paraguay Natl Inst Publ Hlth, Prague, Czech Republic Gaetano Fucito Hosp, Mercato San Severino, Italy Univ Groningen, Groningen, Netherlands Karolinska Inst, Huddinge, Sweden Ctr Estudios Nutr Infantil, Buenos Aires, DF, Argentina Univ Porto, Porto, Portugal Univ Zaragoza, Zaragoza, Spain Santiago de Compostela Univ, Santiago De Compostela, Spain Minist Hlth, Ankara, Turkey Council Agr Res & Econ, Rome, Italy Fed Univ Rio Grande, Rio Grande, Brazil India Diabet Res Fdn, Chennai, Tamil Nadu, India Duke NUS Med Sch, Singapore, Singapore ICMR Natl Inst Med Stat, New Delhi, India Singapore Eye Res Inst, Singapore, Singapore Acad Sinica, Taipei, Taiwan Capital Inst Pediat, Beijing, Peoples R China Duke Univ, Durham, NH USA Kailuan Gen Hosp, Tangshan, Peoples R China Univ Oxford, Oxford, England Ahvaz Jundishapur Univ Med Sci, Ahvaz, Iran Gertner Inst Epidemiol & Hlth Policy Res, Ramat Gan, Israel Natl Ctr Publ Hlth & Anal, Sofia, Bulgaria Univ Fribourg, Fribourg, Switzerland Minist Hlth & Welf, Taipei, Taiwan CIBER Epidemiol & Salud Publ, Murcia, Spain Univ Southern Denmark, Odense, Denmark Univ Estadual Paulista, Presidente Prudente, Brazil Med Univ Silesia, Katowice, Poland Charles Univ Prague, Prague, Czech Republic Primary Hlth Care, Floriana, Malta Carol Davila Univ Med & Pharm, Bucharest, Romania Katholieke Univ Leuven, Leuven, Belgium STAT Canada, Ottawa, ON, Canada UMR CNRS MNHN 7206 Ecoanthropol, Marseille, France Agcy Prevent & Social Med, Bregenz, Austria Univ Southampton, Southampton, Hants, England Inst Pasteur, Lille, France Malawi Epidemiol & Intervent Res Unit, Lilongwe, Malawi CIBEROBN, Madrid, Spain Univ Debrecen, Debrecen, Hungary Univ Med & Pharm Carol Davila, Bucharest, Romania Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil CNR, Reggio Di Calabria, Italy Eftimie Murgu Univ Resita, Resita, Romania Spanish Agcy Food Safety & Nutr, Madrid, Spain Indian Stat Inst, Kolkata, India Tabriz Hlth Serv Management Res Ctr, Tabriz, Iran Geneva Univ Hosp, Geneva, Switzerland Sciensano, Brussels, Belgium Univ Med Ctr Groningen, Groningen, Netherlands Natl Res Ctr Prevent Med, Moscow, Russia Innovating Hlth Int, Port Au Prince, Haiti Univ Montreal, Montreal, PQ, Canada French Natl Res Inst Sustainable Dev, Montpellier, France French Publ Hlth Agcy, St Maurice, France Mediterranea Cardioctr, Naples, Italy Univ Vale Rio dos Sinos, Sao Leopoldo, Brazil Natl Inst Hyg Epidemiol & Microbiol, Havana, Cuba Natl Council Sci & Tech Res, Buenos Aires, DF, Argentina Minist Hlth & Med Educ, Tehran, Iran Univ Novi Sad, Novi Sad, Serbia Natl Inst Nutr, Hanoi, Vietnam Univ Queensland, Brisbane, Qld, Australia Ist Super Sanita, Rome, Italy Univ Cuenca, Cuenca, Ecuador Helmholtz Zentrum Munchen, Munich, Germany Univ Tehran Med Sci, Tehran, Iran Minist Sante & Hyg Publ, Abidjan, Cote Ivoire Univ Hosp Dusseldorf, Dusseldorf, Germany Natl Inst Cardiol, Warsaw, Poland Beijing Ctr Dis Prevent & Control, Beijing, Peoples R China UMI 3189 ESS, Marseille, France Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA Scuola Super Sant Anna, Pisa, Italy Univ Latvia, Riga, Latvia Minist Hlth & Med Serv, Gizo, Solomon Islands Hormozgan Univ Med Sci, Bandar Abbas, Iran Univ Benin, Benin, Nigeria Univ Skovde, Skovde, Sweden Natl Inst Nutr & Food Technol, Tunis, Tunisia Univ West Indies, Kingston, Jamaica Univ Calif Davis, Davis, CA 95616 USA Univ Stellenbosch, Cape Town, South Africa Univ Duisburg Essen, Duisburg, Germany Karadeniz Tech Univ, Trabzon, Turkey Univ Helsinki, Helsinki, Finland Mashhad Univ Med Sci, Mashhad, Razavi Khorasan, Iran Rafsanjan Univ Med Sci, Rafsanjan, Iran Queens Univ Belfast, Belfast, Antrim, North Ireland Tabriz Univ Med Sci, Tabriz, Iran Fasa Univ Med Sci, Fasa, Iran Shiraz Univ Med Sci, Shiraz, Iran Baqai Med Univ, Karachi, Pakistan Ctr Salud Villanueva Norte, Badajoz, Spain Hosp Don Benito Villanueva Serena, Badajoz, Spain Minist Hlth, Buenos Aires, DF, Argentina Univ Insubria, Varese, Italy Pontificia Univ Catolica Chile, Santiago, Chile Inst Mother & Child Hlth, Warsaw, Poland Swiss Trop & Publ Hlth Inst, Basel, Switzerland Univ Tartu, Tartu, Estonia Univ Sains Malaysia, Kota Baharu, Kelantan, Malaysia Umea Univ, Umea, Sweden Univ Fed Sao Paulo, Sao Paulo, Brazil Hosp Univ Son Espases, Palma De Mallorca, Spain Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil Univ Sumatera Utara, Medan, Indonesia Kindai Univ, Osaka, Japan Kyoto Univ, Kyoto, Japan Med Univ Warsaw, Warsaw, Poland Jagiellonian Univ, Med Coll, Krakow, Poland Minist Salute DG Prevenz Sanit, Rome, Italy Univ Catania, Catania, Italy CIBER Epidemiol & Salud Publ, Alicante, Spain Africa Hlth Res Inst, Mtubatuba, South Africa Univ Geneva, Med Sch, Geneva, Switzerland CIBER Epidemiol & Salud Publ, Barcelona, Spain Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil Univ Utrecht, Utrecht, Netherlands Wageningen Univ, Wageningen, Netherlands Univ Adelaide, Adelaide, SA, Australia Lund Univ, Lund, Sweden Aristotle Univ Thessaloniki, Thessaloniki, Greece Inst Natl Sante & Rech Med, Villejuif, France Minist Hlth, Jerusalem, Israel McGill Univ, Montreal, PQ, Canada Gasol Fdn, Barcelona, Spain PASs Hirszfeld Inst Immunol & Expt Therapy, Wroclaw, Poland Univ Politecn Madrid, Madrid, Spain St Annes Univ Hosp, Brno, Czech Republic Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico Ctr Estudios Diabet AC, Mexico City, DF, Mexico Univ Autonoma Santo Domingo, Santo Domingo, Dominican Rep Minist Hlth, Lisbon, Portugal Inst Clin & Expt Med, Prague, Czech Republic Childrens Mem Hlth Inst, Warsaw, Poland Natl Ctr Cardiovasc Dis, Beijing, Peoples R China Univ Ferrara, Ferrara, Italy Author Sanitaria San Marino, San Marino, CA USA Iceland Heart Assoc, Kopavogur, Iceland Univ Icesi, Cali, Colombia Univ Estadual Montes Claros, Montes Claros, MG, Brazil Kings Coll London, London, England Int Agcy Res Canc, Lyon, France Capital Med Univ, Beijing, Peoples R China Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China Healis Sekhsaria Inst Publ Hlth, Navi Mumbai, India Eternal Heart Care Ctr & Res Inst, Jaipur, Rajasthan, India Univ Ibadan, Ibadan, Nigeria Inst Clin Effectiveness & Hlth Policy, Buenos Aires, DF, Argentina Natl Hlth Insurance Serv, Wonju, South Korea Prevent Metab Disorders Res Ctr, Tehran, Iran Res & Educ Inst Child Hlth, Nicosia, Cyprus Danish Canc Soc Res Ctr, Copenhagen, Denmark Univ West Indies, Cave Hill, Barbados Kermanshah Univ Med Sci, Kermanshah, Iran Univ Eastern Finland, Kuopio, Finland Beijing Inst Ophthalmol, Beijing, Peoples R China Int Hellen Univ, Thessaloniki, Greece Kyushu Univ, Fukuoka, Japan Univ Bergen, Bergen, Norway Tulane Univ, New Orleans, LA USA Natl Res Inst Hlth & Family Planning, Beijing, Peoples R China Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China Univ Pecs, Pecs, Hungary Danish Hlth Author, Copenhagen, Denmark Joep Lange Inst, Amsterdam, Netherlands Univ Fed Pernambuco, Recife, PE, Brazil Oulu Univ Hosp, Oulu, Finland Univ Autonoma Bucaramanga, Bucaramanga, Colombia Swiss Fed Inst Technol, Zurich, Switzerland Chron Dis Res Ctr, Tehran, Iran Univ Hong Kong, Hong Kong, Peoples R China Chinese Univ Hong Kong, Hong Kong, Peoples R China Univ Western Australia, Perth, WA, Australia Kingston Hlth Sci Ctr, Kingston, ON, Canada Fdn Oftalmol Santander, Bucaramanga, Colombia Univ Oran 1, Oran, Algeria Nay Pyi Taw, Independent Publ Hlth Specialist, Nay Pyi Taw, Myanmar Minist Hlth & Sports, Nay Pyi Taw, Myanmar Peking Univ, Beijing, Peoples R China Natl Inst Publ Hlth, Bucharest, Romania Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands Amer Univ Beirut, Beirut, Lebanon CIBER Epidemiol & Salud Publ, San Sebastian, Spain Cairo Univ, Cairo, Egypt Erasmus MC, Rotterdam, Netherlands Med Univ Varna, Varna, Bulgaria Univ Tokyo, Tokyo, Japan Deakin Univ, Geelong, Vic, Australia Tokyo Metropolitan Inst Gerontol, Tokyo, Japan Hadassah Univ Med Ctr, Jerusalem, Israel Norwegian Univ Sci & Technol, Trondheim, Norway Univ Melbourne, Melbourne, Vic, Australia Sports Univ Tirana, Tirana, Albania Univ Hosp Ctr Zagreb, Zagreb, Croatia Univ Zagreb, Sch Med, Zagreb, Croatia Heart Fdn, Melbourne, Vic, Australia Guangzhou 12th Hosp, Guangzhou, Peoples R China Univ Eugenio Maria Hostos, Santo Domingo, Dominican Rep Simon Fraser Univ, Burnaby, BC, Canada Inst Mol & Clin Ophthalmol Basel, Basel, Switzerland Univ New South Wales, Sydney, NSW, Australia World Hlth Org Country Off, Delhi, India Guilan Univ Med Sci, Rasht, Iran Inst Publ Hlth, Belgrade, Serbia Univ Opole, Opole, Poland Finnish Inst Hlth & Welf, Helsinki, Finland Gulu Univ, Gulu, Uganda Univ Crete, Iraklion, Greece Sri Venkateswara Univ, Tirupati, Andhra Pradesh, India Sree Chitra Tirunal Inst Med Sci & Technol, Trivandrum, Kerala, India Hellen Med Assoc Obes, Athens, Greece Natl & Kapodistrian Univ Athens, Athens, Greece Maharajgunj Med Campus, Kathmandu, Nepal Aarhus Univ, Aarhus, Denmark Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA Pennington Biomed Res Ctr, Baton Rouge, LA USA Natl Inst Epidemiol, Chennai, Tamil Nadu, India Univ Munster, Munster, Germany Israel Ctr Dis Control, Ramat Gan, Israel Res Inst Primordial Prevent Noncommunicable Dis, Esfahan, Iran Amsterdam UMC Publ Hlth Res Inst, Amsterdam, Netherlands South African Med Res Council, Cape Town, South Africa Kyrgyz State Med Acad, Bishkek, Kyrgyzstan Res Inst Child Nutr, Dortmund, Germany Shahid Beheshti Univ Med Sci, Tehran, Iran Univ Cambridge, Cambridge, England Mazandaran Univ Med Sci, Sari, Iran Hypertens Res Ctr, Esfahan, Iran Med Univ Innsbruck, Innsbruck, Austria Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania Yonsei Univ, Coll Med, Seoul, South Korea Natl Canc Ctr, Goyang Si, South Korea Univ Coll South Denmark, Haderslev, Denmark Stat Austria, Vienna, Austria BP Koirala Inst Hlth Sci, Dharan, Nepal Univ Vienna, Vienna, Austria Tartu Univ Clin, Tartu, Estonia Kansai Med Univ, Hirakata, Osaka, Japan Hungarian Sch Sport Federat, Budapest, Hungary Minist Hlth & Qual Life, Port Louis, Mauritius Univ Hosp Ulm, Ulm, Germany North West Univ, Potchefstroom, South Africa Univ Jyvaskyla, Jyvaskyla, Finland Inst Publ Hlth, Podgorica, Montenegro Amrita Inst Med Sci, Cochin, Kerala, India Inst Endocrinol, Prague, Czech Republic All India Inst Med Sci, New Delhi, India African Populat & Hlth Res Ctr, Nairobi, Kenya Hanoi Univ Publ Hlth, Hanoi, Vietnam Hassan First Univ Settat, Settat, Morocco Minist Hlth, Algiers, Algeria Harokopio Univ, Athens, Greece Sahlgrens Acad, Gothenburg, Sweden Endocrinol & Metab Res Ctr, Tehran, Iran Univ Publ Hlth, Yangon, Myanmar Int Food Policy Res Inst, Dakar, Senegal Natl Univ Singapore, Singapore, Singapore Hong Kong Polytech Univ, Hong Kong, Peoples R China Tampere Univ Hosp, Tampere, Finland Univ Douala, Douala, Cameroon Univ Cape Town, Cape Town, South Africa Natl Inst Hlth Dev, Tallinn, Estonia West Virginia Univ, Morgantown, WV 26506 USA Oswaldo Cruz Fdn Rene Rachou Res Inst, Belo Horizonte, MG, Brazil Natl Taiwan Univ, Taipei, Taiwan Univ Chinese Acad Sci, Shanghai, Peoples R China Uppsala Univ, Uppsala, Sweden Taipei Med Univ, Taipei, Taiwan Sports Med Ctr Minho, Braga, Portugal Univ San Martin Porres, Lima, Peru Consejeria Sanidad Junta Castilla & Leon, Valladolid, Spain Univ Fed Ciencias Saude Porto Alegre, Porto Alegre, RS, Brazil Norrbotten Cty Council, Lulea, Sweden Ilembula Lutheran Hosp, Ilembula, Iran Univ Fed Ouro Preto, Ouro Preto, Brazil Univ Coimbra, Coimbra, Portugal Coimbra Univ Hosp Ctr, Coimbra, Portugal Inst Neurosci Natl Res Council, Padua, Italy Baker Heart & Diabet Inst, Melbourne, Vic, Australia Agr Univ Athens, Athens, Greece Hosp Israelita Albert Einstein, Sao Paulo, Brazil SB RAS Fed Res Ctr Inst Cytol & Genet, Novosibirsk, Russia Univ Otago, Dunedin, New Zealand Univ Padua, Padua, Italy Hellen Mediterranean Univ, Siteia, Greece Loughborough Univ, Loughborough, Leics, England Minist Hlth, Nicosia, Cyprus Lausanne Univ Hosp, Lausanne, Switzerland Escola Nacl Saude Publ Sergio Arouca, Rio De Janeiro, Brazil CIBERCV, Madrid, Spain Mary Immaculate Coll, Limerick, Ireland Emory Univ, Atlanta, GA 30322 USA Hungarian Soc Sports Med, Budapest, Hungary Paracelsus Med Univ, Salzburg, Austria Univ Estadual Centro Oeste, Guarapuava, Brazil Sherikashmir Inst Med Sci, Srinagar, India UiT Arctic Univ Norway, Tromso, Norway ICMR Natl Ctr Dis Informat & Res, Bengaluru, India Cape Peninsula Univ Technol, Cape Town, South Africa Brown Univ, Providence, RI 02912 USA London Sch Hyg & Trop Med, London, England Univ Edinburgh, Edinburgh, Midlothian, Scotland Shahid Sadoughi Univ Med Sci, Tehran, Iran Inst Natl Sante & Rech Med, Lille, France Robert Koch Inst, Berlin, Germany Univ Lisbon, Lisbon, Portugal Womens Social & Hlth Studies Fdn, Trivandrum, Kerala, India Democritus Univ, Alexandroupolis, Greece Grigore T Popa Univ Med & Pharm, Iasi, Romania Univ Firenze, Florence, Italy Ain Shams Univ, Cairo, Egypt Isfahan Cardiovasc Res Ctr, Esfahan, Iran Univ Strasbourg, Strasbourg, France Mulago Hosp, Kampala, Uganda Univ San Carlos, Guatemala City, Guatemala Univ Limpopo, Sovenga, South Africa Univ Med Sci Cienfuegos, Cienfuegos, Cuba Royal Coll Surgeons Ireland, Dublin, Ireland Trobe Univ, Melbourne, Vic, Australia Int Inst Mol & Cell Biol, Warsaw, Poland Inst Conmemorat Gorgas Estudios Salud, Panama City, Panama World Hlth Org Country Off, Lilongwe, Malawi Dept Publ Hlth, Nay Pyi Taw, Myanmar Univ Brescia, Brescia, Italy Minist Hlth & Social Protect, Dushanbe, Tajikistan Univ Limerick, Limerick, Ireland Croatian Inst Publ Hlth, Zagreb, Croatia Univ Kebangsaan Malaysia, Kuala Lumpur, Malaysia Bushehr Univ Med Sci, Bushehr, Iran Ulm Univ, Ulm, Germany Dept Stat, Kuala Lumpur, Malaysia Kobe Univ, Kobe, Hyogo, Japan Suraj Eye Inst, Nagpur, Maharashtra, India UNICEF, Yaounde, Cameroon Univ Med Greifswald, Greifswald, Germany Karolinska Inst, Stockholm, Sweden Natl Inst Hyg & Epidemiol, Hanoi, Vietnam Univ Med & Pharm Ho Chi Minh City, Ho Chi Minh City, Vietnam Hanoi Med Univ, Hanoi, Vietnam LifeDoc Hlth, Memphis, TN USA Heartfile, Islamabad, Pakistan Eastern Mediterranean Publ Hlth Network, Amman, Jordan Univ Manchester, Manchester, Lancs, England State Univ Med & Pharm, Kishinev, Moldova Tachikawa Gen Hosp, Nagaoka, Niigata, Japan Korea Ctr Dis Control & Prevent, Cheongju, South Korea Japan Wildlife Res Ctr, Tokyo, Japan Istanbul Univ, Istanbul, Turkey Minist Hlth, Bandar Seri Begawan, Brunei Univ Fed Parana, Curitiba, Parana, Brazil Univ Madeira, Funchal, Portugal Univ Puerto Rico, San Juan, PR 00936 USA Ctr Clin Res & Prevent, Glostrup, Denmark MRC Lifecourse Epidemiol Unit, Southampton, Hants, England Kwame Nkrumah Univ Sci & Technol, Kumasi, Ghana UniSante, Lausanne, Switzerland Inst Canc Res, Prevent & Clin Network, Florence, Italy Univ Wisconsin, Madison, WI USA Heidelberg Univ, Heidelberg, Germany IRCCS Ente Osped Specializzato Gastroenterol S de, Bari, Italy Zayed Univ, Abu Dhabi, U Arab Emirates Catholic Univ Daegu, Daegu, South Korea Univ Med Pharm Sci & Technol Targu Mures, Targu Mures, Romania Jivandeep Hosp, Anand, Gujarat, India South African Med Res Council, Durban, South Africa Natl Dent Care Ctr Singapore, Singapore, Singapore Univ Malaga, Malaga, Spain Univ Hosp Varese, Varese, Italy Vietnam Natl Heart Inst, Hanoi, Vietnam Clin Med Avanzada Dr Abel Gonzalez, Santo Domingo, Dominican Rep Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany Univ Sarajevo, Sarajevo, Bosnia & Herceg Cardiovasc Prevent Ctr Udine, Udine, Italy Pisa Univ Hosp, Pisa, Italy Minist Hlth & Med Serv, Honiara, Solomon Islands Publ Hlth Agcy Catalonia, Barcelona, Spain Inst Hosp del Mar Invest Med, Barcelona, Spain Ardabil Univ Med Sci, Ardebil, Iran Ctr Dis Prevent & Control, Riga, Latvia Alborz Univ Med Sci, Karaj, Iran Minist Hlth, Hanoi, Vietnam Pure Earth, Dhaka, Bangladesh Inst Epidemiol Dis Control & Res, Dhaka, Bangladesh Univ Turku, Turku, Finland Inst Univ Invest Atenc Primaria Jordi Gol, Girona, Spain Univ Putra Malaysia, Serdang, Malaysia Univ Malaya, Kuala Lumpur, Malaysia Sotiria Hosp, Athens, Greece Univ Valencia, Valencia, Spain Univ Philippines, Manila, Philippines Slovak Acad Sci, Bratislava, Slovakia Nutr Res Fdn, Barcelona, Spain Minas Gerais State Secretariat Hlth, Belo Horizonte, MG, Brazil CS S Agustin Ibsalut, Palma De Mallorca, Spain Amsterdam Inst Global Hlth & Dev, Amsterdam, Netherlands Natl Inst Hlth Doutor Ricardo Jorge, Lisbon, Portugal Univ Nove Julho, Sao Paulo, Brazil Publ Hlth Agcy Canada, Ottawa, ON, Canada Canarian Hlth Serv, Tenerife, Spain Univ Ind Santander, Bucaramanga, Colombia Assoc Calabrese Epatol, Reggio Di Calabria, Italy Univ Minho, Braga, Portugal Fiji Natl Univ, Suva, Fiji Spanish Nutr Fdn, Madrid, Spain Publ Hlth Agcy Sweden, Stockholm, Sweden Inst Food Sci Natl Res Council, Avellino, Italy Sitaram Bhartia Inst Sci & Res, New Delhi, India Kindergarten Avlonari, Evia, Greece Natl Inst Hlth, Lima, Peru Minist Hlth, Jakarta, Indonesia Catalan Dept Hlth, Barcelona, Spain Biodonostia Hlth Res Inst, San Sebastian, Spain Inst Saude Ambiental, Lisbon, Portugal South Karelia Social & Hlth Care Dist, Lappeenranta, Finland McMaster Univ, Hamilton, ON, Canada Natl Canc Ctr, Tokyo, Japan Univ Sao Paulo Clin Hosp, Sao Paulo, Brazil Hosp Italiano Buenos Aires, Buenos Aires, DF, Argentina Rigshosp, Copenhagen, Denmark Acad Med Ctr Univ Amsterdam, Amsterdam, Netherlands Ctr Oral Hlth Serv & Res Midnorway, Trondheim, Norway Lagos State Univ, Coll Med, Lagos, Nigeria Univ Las Palmas Gran Canaria, Las Palmas Gran Canaria, Spain Comenius Univ, Bratislava, Slovakia Natl Ctr Dis Control & Publ Hlth, Tbilisi, Georgia Nippon Med Sch, Tokyo, Japan Sungkyunkwan Univ, Seoul, South Korea Finnish Inst Occupat Hlth, Helsinki, Finland Publ Hlth Promot & Dev Org, Kathmandu, Nepal St Vincents Hosp, Sydney, NSW, Australia Nes Municipal, Aarnes, Norway Hlth Polytech Jakarta II Inst, Jakarta, Indonesia Diponegoro Univ, Semarang, Indonesia Univ Bari, Bari, Italy Inst Reg Sante Publ, Ouidah, Benin Univ Bordeaux, Bordeaux, France Oslo Metropolitan Univ, Oslo, Norway Inst Publ Hlth, Skopje, North Macedonia Univ Leuven, Leuven, Belgium Lamprecht & Stamm Sozialforsch & Beratung AG, Zurich, Switzerland Inst Natl Sante & Rech Med, Nancy, France Univ Bonn, Bonn, Germany Sotiria Hosp, Sotiria, Greece Kalina Malina Kindergarten, Pazardjik, Bulgaria Jikei Univ, Sch Med, Tokyo, Japan Fu Jen Catholic Univ, Taipei, Taiwan Natl Stat Off, Praia, Cape Verde Natl Inst Publ Hlth Natl Inst Hyg, Warsaw, Poland Deakin Univ, Sydney, NSW, Australia Sci Res Inst Maternal & Child Hlth, Ashkhabad, Turkmenistan Univ Lincoln, Lincoln, England Minist Hlth, Amman, Jordan UNICEF, Niamey, Niger Cent Univ Kerala, Kasaragod, India Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands Hlth Serv Murcia, Murcia, Spain Inst Invest Sanitaria Illes Balears, Menorca, Spain Univ Bologna, Bologna, Italy Hellen Hlth Fdn, Athens, Greece Govt Med Coll, Bhavnagar, Gujarat, India Sefako Makgatho Hlth Sci Univ, Ga Rankuwa, South Africa Addis Ababa Univ, Addis Ababa, Ethiopia Minist Hlth, Wellington, New Zealand Univ Ctr Occidental Lisandro Alvarado, Barquisimeto, Venezuela Meharry Med Coll, Nashville, TN 37208 USA Dokuz Eylul Univ, Izmir, Turkey Univ Tampere, Tays Eye Ctr, Tampere, Finland Sabiha Gokcen Ilkokulu, Ankara, Turkey Polytech Inst Porto, Porto, Portugal Icahn Sch Med Mt Sinai, New York, NY 10029 USA Univ CEU San Pablo, Madrid, Spain CNR, Pisa, Italy Univ Miguel Hernandez, Alicante, Spain Vrije Univ Amsterdam, Amsterdam, Netherlands Sunflower Nursery Sch, Craiova, Romania North Karelia Ctr Publ Hlth, Joensuu, Finland Univ Witwatersrand, Johannesburg, South Africa Med Univ Vienna, Vienna, Austria Cork Inst Technol, Cork, Ireland Inst Med Res, Kuala Lumpur, Malaysia Xinjiang Med Univ, Urumqi, Peoples R China Shanghai Educ Dev Co Ltd, Shanghai, Peoples R China Minist Hlth, Auckland, New Zealand Rebro Univ, Rebro, Sweden St Georges Univ London, London, England Univ Indonesia, Jakarta, Indonesia Minist Agr & Rural Affairs, Inst Food & Nutr Dev, Beijing, Peoples R China Fudan Univ, Childrens Hosp, Shanghai, Peoples R China Univ Cyprus, Nicosia, Cyprus Niigata Univ, Niigata, Japan Int Med Univ, Shah Alam, Selangor, Malaysia Hellen Mediterranean Univ, Iraklion, Greece Iran Univ Med Sci, Tehran, Iran Ctr Diabet & Endocrine Care, Srinagar, India Peking Univ First Hosp, Beijing, Peoples R China Jiangsu Prov Ctr Dis Control & Prevent, Nanjing, Peoples R China Sun Yat Sen Univ, Guangzhou, Peoples R China West Kazakhstan Med Univ, Aktobe, Kazakhstan Inner Mongolia Med Univ, Hohhot, Peoples R China Przedszkole 81, Warsaw, Poland Univ Estadual Paulista, Presidente Prudente, Brazil
Published: 2021

30. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants

Author: Zhou, B, Carrillo-Larco, Rm, Danaei, G, Riley, Lm, Paciorek, Cj, Stevens, Ga, Gregg, Ew, Bennett, Je, Solomon, B, Singleton, Rk, Sophiea, Mk, Iurilli, Mlc, Lhoste, Vpf, Cowan, Mj, Savin, S, Woodward, M, Balanova, Y, Cifkova, R, Damasceno, A, Elliott, P, Farzadfar, F, He, J, Ikeda, N, Kengne, Ap, Khang, Yh, Kim, Hc, Laxmaiah, A, Lin, Hh, Maira, Pm, Miranda, Jj, Neuhauser, H, Sundstrom, J, Varghese, C, Widyahening, Is, Zdrojewski, T, Ezzati, M, Abarca-Gomez, L, Abdeen, Za, Rahim, Hfa, Abu-Rmeileh, Nm, Acosta-Cazares, B, Adams, Rj, Aekplakorn, W, Afsana, K, Afzal, S, Agdeppa, Ia, Aghazadeh-Attari, J, Aguilar-Salinas, Ca, Agyemang, C, Ahmad, Na, Ahmadi, A, Ahmadi, N, Ahmadizar, F, Ahmed, Sh, Ahrens, W, Ajlouni, K, Al-Raddadi, R, Alarouj, M, Albuhairan, F, Aldhukair, S, Ali, Mm, Alkandari, A, Alkerwi, A, Allin, K, Aly, E, Amarapurkar, Dn, Amougou, N, Amouyel, P, Andersen, Lb, Anderssen, Sa, Anjana, Rm, Ansari-Moghaddam, A, Ansong, D, Aounallah-Skhiri, H, Araujo, J, Ariansen, I, Aris, T, Arku, Re, Arlappa, N, Aryal, Kk, Aspelund, T, Assah, Fk, Assuncao, Mcf, Auvinen, J, Avdicova, M, Azevedo, A, Azimi-Nezhad, M, Azizi, F, Azmin, M, Babu, Bv, Bahijri, S, Balakrishna, N, Bamoshmoosh, M, Banach, M, Banadinovic, M, Bandosz, P, Banegas, Jr, Baran, J, Barbagallo, Cm, Barcelo, A, Barkat, A, Barreto, M, Barros, Ajd, Barros, Mvg, Bartosiewicz, A, Basit, A, Bastos, Jld, Bata, I, Batieha, Am, Batyrbek, A, Baur, La, Beaglehole, R, Belavendra, A, Ben Romdhane, H, Benet, M, Benson, Ls, Berkinbayev, S, Bernabe-Ortiz, A, Bettiol, H, Bezerra, J, Bhagyalaxmi, A, Bhargava, Sk, Bia, D, Biasch, K, Lele, Ecb, Bikbov, Mm, Bista, B, Bjerregaard, P, Bjertness, E, Bjertness, Mb, Bjorkelund, C, Bloch, Kv, Blokstra, A, Bo, S, Bobak, M, Boeing, H, Boggia, Jg, Boissonnet, Cp, Bojesen, Se, Bongard, V, Bonilla-Vargas, A, Bopp, M, Borghs, H, Bovet, P, Boyer, Cb, Braeckman, L, Brajkovich, I, Branca, F, Breckenkamp, J, Brenner, H, Brewster, Lm, Briceno, Y, Brito, M, Bruno, G, Bueno-de-Mesquita, Hb, Bueno, G, Bugge, A, Burns, C, Bursztyn, M, de Leon, Ac, Cacciottolo, J, Cameron, C, Can, G, Candido, Apc, Capanzana, Mv, Capkova, N, Capuano, E, Capuano, V, Cardoso, Vc, Carlsson, Ac, Carvalho, J, Casanueva, Ff, Censi, L, Cervantes-Loaiza, M, Chadjigeorgiou, Ca, Chamukuttan, S, Chan, Aw, Chan, Q, Chaturvedi, Hk, Chaturvedi, N, Chee, Ml, Chen, Cj, Chen, Ff, Chen, Hs, Chen, Sh, Chen, Zm, Cheng, Cy, Cheraghian, B, Dekkaki, Ic, Chetrit, A, Chien, Kl, Chiolero, A, Chiou, St, Chirita-Emandi, A, Chirlaque, Md, Cho, B, Christensen, K, Christofaro, Dg, Chudek, J, Cinteza, E, Claessens, F, Clarke, J, Clays, E, Cohen, E, Concin, H, Cooper, C, Coppinger, Tc, Costanzo, S, Cottel, D, Cowell, C, Craig, Cl, Crampin, Ac, Crujeiras, Ab, Cruz, Jj, Csilla, S, Cui, Lf, Cureau, Fv, Cuschieri, S, D'Arrigo, G, D'Orsi, E, Dallongeville, J, Dankner, R, Dantoft, Tm, Dauchet, L, Davletov, K, De Backer, G, De Bacquer, D, De Curtis, A, de Gaetano, G, De Henauw, S, de Oliveira, Pd, De Ridder, D, De Smedt, D, 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Life, APH - Societal Participation & Health, Public and occupational health, APH - Health Behaviors & Chronic Diseases, VU University medical center, APH - Personalized Medicine, Psychiatry, APH - Mental Health, Bin Zhou, Rodrigo M Carrillo-Larco, Goodarz Danaei, Leanne M Riley, Christopher J Paciorek, Gretchen A Stevens, Edward W Gregg, James E Bennett, Bethlehem Solomon, Rosie K Singleton, Marisa K Sophiea, Maria Lc Iurilli, Victor Pf Lhoste, Melanie J Cowan, Stefan Savin, Mark Woodward, Yulia Balanova, Renata Cifkova, Albertino Damasceno, Paul Elliott, Farshad Farzadfar, Jiang He, Nayu Ikeda, Andre P Kengne, Young-Ho Khang, Hyeon Chang Kim, Avula Laxmaiah, Hsien-Ho Lin, Paula Margozzini Maira, J Jaime Miranda, Hannelore Neuhauser, Johan Sundström, Cherian Varghese, Indah S Widyahening, Tomasz Zdrojewski, Leandra Abarca-Gómez, Ziad A Abdeen, Hanan F Abdul Rahim, Niveen M Abu-Rmeileh, Benjamin Acosta-Cazares, Robert J Adams, Wichai Aekplakorn, Kaosar Afsana, Shoaib Afzal, Imelda A 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Huybrechts, Nahla Hwalla, Licia Iacoviello, Anna G Iannone, Mohsen M Ibrahim, Norazizah Ibrahim Wong, M Arfan Ikram, Violeta Iotova, Vilma E Irazola, Takafumi Ishida, Godsent C Isiguzo, Muhammad Islam, Sheikh Mohammed Shariful Islam, Masanori Iwasaki, Rod T Jackson, Jeremy M Jacobs, Hashem Y Jaddou, Tazeen Jafar, Kenneth James, Konrad Jamrozik, Imre Janszky, Edward Janus, Marjo-Riitta Jarvelin, Grazyna Jasienska, Ana Jelaković, Bojan Jelaković, Garry Jennings, Anjani Kumar Jha, Chao Qiang Jiang, Ramon O Jimenez, Karl-Heinz Jöckel, Michel Joffres, Mattias Johansson, Jari J Jokelainen, Jost B Jonas, Torben Jørgensen, Pradeep Joshi, Farahnaz Joukar, Jacek Jóżwiak, Anne Juolevi, Gregor Jurak, Vesna Jureša, Rudolf Kaaks, Anthony Kafatos, Eero O Kajantie, Zhanna Kalmatayeva, Natasa Kalpourtzi, Ofra Kalter-Leibovici, Freja B Kampmann, Srinivasan Kannan, Eva Karaglani, Line L Kårhus, Khem B Karki, Marzieh Katibeh, Joanne Katz, Jussi Kauhanen, Prabhdeep Kaur, Maryam Kavousi, Gyulli M 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William A Neal, Azim Nejatizadeh, Ilona Nenko, Martin Neovius, Chung T Nguyen, Nguyen D Nguyen, Quang V Nguyen, Quang Ngoc Nguyen, Ramfis E Nieto-Martínez, Teemu J Niiranen, Yury P Nikitin, Toshiharu Ninomiya, Sania Nishtar, Marina A Njelekela, Marianna Noale, Oscar A Noboa, Ahmad Ali Noorbala, Teresa Norat, Maria Nordendahl, Børge G Nordestgaard, Noto Davide, Natalia Nowak-Szczepanska, Mohannad Al Nsour, Baltazar Nunes, Terence W O'Neill, Dermot O'Reilly, Caleb Ochimana, Eiji Oda, Augustine N Odili, Kyungwon Oh, Kumiko Ohara, Ryutaro Ohtsuka, Valérie Olié, Maria Teresa A Olinto, Isabel O Oliveira, Mohd Azahadi Omar, Altan Onat, Sok King Ong, Lariane M Ono, Pedro Ordunez, Rui Ornelas, Pedro J Ortiz, Clive Osmond, Sergej M Ostojic, Afshin Ostovar, Johanna A Otero, Kim Overvad, Ellis Owusu-Dabo, Fred Michel Paccaud, Cristina Padez, Elena Pahomova, Karina Mary de Paiva, Andrzej Pająk, Domenico Palli, Luigi Palmieri, Wen-Harn Pan, Songhomitra Panda-Jonas, Francesco Panza, Mariela Paoli, Dimitrios Papandreou, Soon-Woo Park, Suyeon Park, Winsome R Parnell, Mahboubeh Parsaeian, Patrick Pasquet, Nikhil D Patel, Halyna Pavlyshyn, Ivan Pećin, Mangesh S Pednekar, João M Pedro, Nasheeta Peer, Sergio Viana Peixoto, Markku Peltonen, Alexandre C Pereira, Karen Gda Peres, Marco A Peres, Annette Peters, Janina Petkeviciene, Niloofar Peykari, Son Thai Pham, Rafael N Pichardo, Iris Pigeot, Hynek Pikhart, Aida Pilav, Lorenza Pilotto, Freda Pitakaka, Aleksandra Piwonska, Andreia N Pizarro, Pedro Plans-Rubió, Ozren Polašek, Miquel Porta, Anil Poudyal, Farhad Pourfarzi, Akram Pourshams, Hossein Poustchi, Rajendra Pradeepa, Alison J Price, Jacqueline F Price, Rui Providencia, Soile E Puhakka, Maria Puiu, Margus Punab, Radwan F Qasrawi, Mostafa Qorbani, Daniel Queiroz, Tran Quoc Bao, Ivana Radić, Ricardas Radisauskas, Salar Rahimikazerooni, Mahfuzar Rahman, Olli Raitakari, Manu Raj, Ellina M Rakhimova, Sudha Ramachandra Rao, Ambady Ramachandran, Elisabete Ramos, Lekhraj Rampal, Sanjay 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Krishna, Kurjata, Pawel, Kusuma, Yadlapalli S., Kutsenko, Vladimir, Kuulasmaa, Kari, Kyobutungi, Catherine, Laatikainen, Tiina, Lachat, Carl, Laid, Youcef, Lam, Tai Hing, Landrove, Orlando, Lanska, Vera, Lappas, Georg, Larijani, Bagher, Latt, Tint Swe, Le Coroller, Gwenaelle, Khanh Le Nguyen Bao, Le, Tuyen D., Lee, Jeannette, Lee, Jeonghee, Lehmann, Nils, Lehtimaki, Terho, Lemogoum, Daniel, Levitt, Naomi S., Li, Yanping, Lilly, Christa L., Lim, Wei-Yen, Lima-Costa, M. Fernanda, Lin, Xu, Lin, Yi-Ting, Lind, Lars, Lingam, Vijaya, Linneberg, Allan, Lissner, Lauren, Litwin, Mieczyslaw, Lo, Wei-Cheng, Loit, Helle-Mai, Lopez-Garcia, Esther, Lopez, Tania, Lotufo, Paulo A., Lozano, Jose Eugenio, Lovrencic, Iva Lukacevic, Lukrafka, Janice L., Luksiene, Dalia, Lundqvist, Annamari, Lundqvist, Robert, Lunet, Nuno, Lustigova, Michala, Luszczki, Edyta, Ma, Guansheng, Ma, Jun, Machado-Coelho, George L. L., Machado-Rodrigues, Aristides M., Macia, Enguerran, Macieira, Luisa M., Madar, Ahmed A., Maggi, Stefania, Magliano, Dianna J., Magriplis, Emmanuella, Mahasampath, Gowri, Maire, Bernard, Majer, Marjeta, Makdisse, Marcia, Malekzadeh, Fatemeh, Malekzadeh, Reza, Malhotra, Rahul, Mallikharjuna, Kodavanti, Malyutina, Sofia K., Maniego, Lynell V., Manios, Yannis, Mann, Jim I., Mansour-Ghanaei, Fariborz, Manzato, Enzo, Marcil, Anie, Margozzini, Paula, Marild, Staffan B., Glavic, Mihalea Marinovic, Marques-Vidal, Pedro, Marques, Larissa Pruner, Marrugat, Jaume, Martorell, Reynaldo, Mascarenhas, Luis P., Matasin, Marija, Mathiesen, Ellisiv B., Mathur, Prashant, Matijasevich, Alicia, Matlosz, Piotr, Matsha, Tandi E., Mavrogianni, Christina, Mbanya, Jean Claude N., Mc Donald Posso, Anselmo J., McFarlane, Shelly R., McGarvey, Stephen T., McLachlan, Stela, McLean, Rachael M., McLean, Scott B., McNulty, Breige A., Benchekor, Sounnia Mediene, Medzioniene, Jurate, Mehdipour, Parinaz, Mehlig, Kirsten, Mehrparvar, Amir Houshang, Meirhaeghe, Aline, Meisinger, Christa, Mendoza Montano, Carlos, Menezes, Ana Maria B., Menon, Geetha R., Mereke, Alibek, Meshram, Indrapal I., Metspalu, Andres, Meyer, Haakon E., Mi, Jie, Michels, Nathalie, Mikkel, Kairit, Milkowska, Karolina, Miller, Jody C., Minderico, Claudia S., Mini, G. K., Mirjalili, Mohammad Reza, Mirrakhimov, Erkin, Misigoj-Durakovic, Marjeta, Modesti, Pietro A., Moghaddam, Sahar Saeedi, Mohajer, Bahram, Mohamed, Mostafa K., Mohamed, Shukri F., Mohammad, Kazem, Mohammadi, Mohammad Reza, Mohammadi, Zahra, Mohammadifard, Noushin, Mohammadpourhodki, Reza, Mohan, Viswanathan, Mohanna, Salim, Yusoff, Muhammad Fadhli Mohd, Mohebbi, Iraj, Mohebi, Farnam, Moitry, Marie, Mollehave, Line T., Molnar, Denes, Momenan, Amirabbas, Mondo, Charles K., Monterrubio-Flores, Eric, Monyeki, Kotsedi Daniel K., Moon, Jin Soo, Moosazadeh, Mahmood, Moreira, Leila B., Morejon, Alain, Moreno, Luis A., Morgan, Karen, Moschonis, George, Mossakowska, Malgorzata, Mostafa, Aya, Mostafavi, Seyed-Ali, Mota, Jorge, Motlagh, Mohammad Esmaeel, Motta, Jorge, Andre Moura-dos-Santos, Marcos, Mridha, Malay K., Msyamboza, Kelias P., Mu, Thet Thet, Muhihi, Alfa J., Muiesan, Maria L., Muller-Nurasyid, Martina, Murphy, Neil, Mursu, Jaakko, Musa, Kamarul Imran, Milanovic, Sanja Music, Musil, Vera, Mustafa, Norlaila, Nabipour, Iraj, Naderimagham, Shohreh, Nagel, Gabriele, Naidu, Balkish M., Najafi, Farid, Nakamura, Harunobu, Namesna, Jana, Nang, Ei Ei K., Nangia, Vinay B., Narake, Sameer, Ndiaye, Ndeye Coumba, Neal, William A., Nejatizadeh, Azim, Nenko, Ilona, Neovius, Martin, Neuhauser, Hannelore K., Nguyen, Chung T., Nguyen, Nguyen D., Nguyen, Quang V., Quang Ngoc Nguyen, Nieto-Martinez, Ramfis E., Niiranen, Teemu J., Nikitin, Yury P., Ninomiya, Toshiharu, Nishtar, Sania, Njelekela, Marina A., Noale, Marianna, Noboa, Oscar A., Noorbala, Ahmad Ali, Norat, Teresa, Nordendahl, Maria, Nordestgaard, Borge G., Noto, Davide, Nowak-Szczepanska, Natalia, Al Nsour, Mohannad, Nunes, Baltazar, O'Neill, Terence W., O'Reilly, Dermot, Ochimana, Caleb, Oda, Eiji, Odili, Augustine N., Oh, Kyungwon, Ohara, Kumiko, Ohtsuka, Ryutaro, Olie, Valerie, Olinto, Maria Teresa A., Oliveira, Isabel O., Omar, Mohd Azahadi, Onat, Altan, Ong, Sok King, Ono, Lariane M., Ordunez, Pedro, Ornelas, Rui, Ortiz, Pedro J., Osmond, Clive, Ostojic, Sergej M., Ostovar, Afshin, Otero, Johanna A., Overvad, Kim, Owusu-Dabo, Ellis, Paccaud, Fred Michel, Padez, Cristina, Pahomova, Elena, de Paiva, Karina Mary, Pajak, Andrzej, Palli, Domenico, Palmieri, Luigi, Pan, Wen-Harn, Panda-Jonas, Songhomitra, Panza, Francesco, Paoli, Mariela, Papandreou, Dimitrios, Park, Soon-Woo, Park, Suyeon, Parnell, Winsome R., Parsaeian, Mahboubeh, Pasquet, Patrick, Patel, Nikhil D., Pavlyshyn, Halyna, Pecin, Ivan, Pednekar, Mangesh S., Pedro, Joao M., Peer, Nasheeta, Peixoto, Sergio Viana, Peltonen, Markku, Pereira, Alexandre C., Peres, Karen G. D. A., Peres, Marco A., Peters, Annette, Petkeviciene, Janina, Peykari, Niloofar, Son Thai Pham, Pichardo, Rafael N., Pigeot, Iris, Pikhart, Hynek, Pilav, Aida, Pilotto, Lorenza, Pitakaka, Freda, Piwonska, Aleksandra, Pizarro, Andreia N., Plans-Rubio, Pedro, Polasek, Ozren, Porta, Miquel, Poudyal, Anil, Pourfarzi, Farhad, Pourshams, Akram, Poustchi, Hossein, Pradeepa, Rajendra, Price, Alison J., Price, Jacqueline F., Providencia, Rui, Puhakka, Soile E., Puiu, Maria, Punab, Margus, Qasrawi, Radwan F., Qorbani, Mostafa, Queiroz, Daniel, Tran Quoc Bao, Radic, Ivana, Radisauskas, Ricardas, Rahimikazerooni, Salar, Rahman, Mahfuzar, Raitakari, Olli, Raj, Manu, Rakhimova, Ellina M., Rao, Sudha Ramachandra, Ramachandran, Ambady, Ramos, Elisabete, Rampal, Lekhraj, Rampal, Sanjay, Rangel Reina, Daniel A., Rarra, Vayia, Rech, Cassiano Ricardo, Redon, Josep, Reganit, Paul Ferdinand M., Regecova, Valeria, Revilla, Luis, Rezaianzadeh, Abbas, Ribeiro, Robespierre, Riboli, Elio, Richter, Adrian, Rigo, Fernando, de Wit, Tobias F. Rinke, Ritti-Dias, Raphael M., Robitaille, Cynthia, Rodriguez-Artalejo, Fernando, del Cristo Rodriguez-Perez, Maria, Rodriguez-Villamizar, Laura A., Roggenbuck, Ulla, Rojas-Martinez, Rosalba, Romaguera, Dora, Romeo, Elisabetta L., Rosengren, Annika, Roy, Joel G. R., Rubinstein, Adolfo, Ruidavets, Jean-Bernard, Sandra Ruiz-Betancourt, Blanca, Ruiz-Castell, Maria, Rusakova, Iuliia A., Russo, Paola, Rutkowski, Marcin, Sabanayagam, Charumathi, Sabbaghi, Hamideh, Sachdev, Harshpal S., Sadjadi, Alireza, Safarpour, Ali Reza, Safi, Sare, Safiri, Saeid, Saidi, Olfa, Saki, Nader, Salanave, Benoit, Salazar Martinez, Eduardo, Salmeron, Diego, Salomaa, Veikko, Salonen, Jukka T., Salvetti, Massimo, Sanchez-Abanto, Jose, Sans, Susana, Santos, Diana A., Santos, Ina S., Santos, Lelita C., Santos, Maria Paula, Santos, Rute, Saramies, Jouko L., Sardinha, Luis B., Sarganas, Giselle, Sarrafzadegan, Nizal, Sathish, Thirunavukkarasu, Saum, Kai-Uwe, Savva, Savvas, Sawada, Norie, Sbaraini, Mariana, Scazufca, Marcia, Schaan, Beatriz D., Schargrodsky, Herman, Schipf, Sabine, Schmidt, Carsten O., Schnohr, Peter, Schoettker, Ben, Schramm, Sara, Schultsz, Constance, Schutte, Aletta E., Sebert, Sylvain, Sein, Aye Aye, Sen, Abhijit, Senbanjo, Idowu O., Sepanlou, Sadaf G., Servais, Jennifer, Shalnova, Svetlana A., Shamah-Levy, Teresa, Shamshirgaran, Morteza, Shanthirani, Coimbatore Subramaniam, Sharafkhah, Maryam, Sharma, Sanjib K., Shaw, Jonathan E., Shayanrad, Amaneh, Shayesteh, Ali Akbar, Shi, Zumin, Shibuya, Kenji, Shimizu-Furusawa, Hana, Shin, Dong Wook, Shirani, Majid, Shiri, Rahman, Shrestha, Namuna, Si-Ramlee, Khairil, Siani, Alfonso, Siantar, Rosalynn, Sibai, Abla M., de Moura Silva, Caroline Ramos, Santos Silva, Diego Augusto, Simon, Mary, Simons, Judith, Simons, Leon A., Sjostrom, Michael, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemyslaw, Smeeth, Liam, So, Hung-Kwan, Soares, Fernanda Cunha, Sobngwi, Eugene, Soderberg, Stefan, Soemantri, Agustinus, Sofat, Reecha, Solfrizzi, Vincenzo, Somi, Mohammad Hossein, Sonestedt, Emily, Song, Yi, Sorensen, Thorkild I. A., Sorgjerd, Elin P., Soric, Maroje, Jerome, Charles Sossa, Soumare, Aicha, Sparboe-Nilsen, Bente, Sparrenberger, Karen, Staessen, Jan A., Starc, Gregor, Stavreski, Bill, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D., Stergiou, George S., Stessman, Jochanan, Stieber, Jutta, Stoeckl, Doris, Stocks, Tanja, Stokwiszewski, Jakub, Stronks, Karien, Strufaldi, Maria Wany, Suka, Machi, Sun, Chien-An, Sung, Yn-Tz, Suriyawongpaisal, Paibul, Sy, Rody G., Syddall, Holly E., Sylva, Rene Charles, Szklo, Moyses, Tai, E. Shyong, Tammesoo, Mari-Liis, Tamosiunas, Abdonas, Tan, Eng Joo, Tang, Xun, Tanser, Frank, Tao, Yong, Tarawneh, Mohammed Rasoul, Tarqui-Mamani, Carolina B., Taylor, Anne, Taylor, Julie, Tebar, William R., Tell, Grethe S., Tello, Tania, Tham, Yih Chung, Thankappan, K. R., Theobald, Holger, Theodoridis, Xenophon, Thinggaard, Mikael, Thomas, Nihal, Thorand, Barbara, Thuesen, Betina H., Timmermans, Erik J., Tjandrarini, Dwi H., Tjonneland, Anne, Toft, Ulla, Tolonen, Hanna K., Tolstrup, Janne S., Topbas, Murat, Topor-Madry, Roman, Jose Tormo, Maria, Tornaritis, Michael J., Torrent, Maties, Torres-Collado, Laura, Touloumi, Giota, Traissac, Pierre, Triantafyllou, Areti, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Trinh, Oanh T. H., Trivedi, Atul, Tshepo, Lechaba, Tsugane, Shoichiro, Tuliakova, Azaliia M., Tulloch-Reid, Marshall K., Tullu, Fikru, Tuomainen, Tomi-Pekka, Tuomilehto, Jaakko, Turley, Maria L., Twig, Gilad, Tynelius, Per, Tzourio, Christophe, Ueda, Peter, Ugel, Eunice, Ulmer, Hanno, Uusitalo, Hannu M. T., Valdivia, Gonzalo, Valvi, Damaskini, van Dam, Rob M., van den Born, Bert-Jan, Van der Heyden, Johan, van der Schouw, Yvonne T., Van Herck, Koen, Hoang Van Minh, Van Schoor, Natasja M., van Valkengoed, Irene G. M., van Zutphen, Elisabeth M., Vanuzzo, Diego, Varbo, Anette, Vasan, Senthil K., Vega, Tomas, Veidebaum, Toomas, Velasquez-Melendez, Gustavo, Veronesi, Giovanni, Verschuren, W. M. Monique, Verstraeten, Roosmarijn, Victora, Cesar G., Viet, Lucie, Villalpando, Salvador, Vineis, Paolo, Vioque, Jesus, Virtanen, Jyrki K., Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vlasoff, Tiina, Vollenweider, Peter, Voutilainen, Ari, Wade, Alisha N., Walton, Janette, Wambiya, Elvis O. A., Bebakar, Wan Mohamad Wan, Mohamud, Wan Nazaimoon Wan, Wanderley Junior, Rildo de Souza, Wang, Ming-Dong, Wang, Ningli, Wang, Qian, Wang, Xiangjun, Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S. Goya, Wareham, Nicholas, Wei, Wenbin, Weres, Aneta, Werner, Bo, Whincup, Peter H., Widhalm, Kurt, Wiecek, Andrzej, Wilks, Rainford J., Willeit, Johann, Willeit, Peter, Williams, Emmanuel A., Wilsgaard, Tom, Wojtyniak, Bogdan, Wong-McClure, Roy A., Wong, Andrew, Wong, Tien Yin, Woo, Jean, Wu, Frederick C., Wu, Shouling, Wyszynska, Justyna, Xu, Haiquan, Xu, Liang, Yaacob, Nor Azwany, Yan, Weili, Yang, Ling, Yang, Xiaoguang, Yang, Yang, Yasuharu, Tabara, Ye, Xingwang, Yiallouros, Panayiotis K., Yoosefi, Moein, Yoshihara, Akihiro, You, San-Lin, Younger-Coleman, Novie O., Yusoff, Ahmad Faudzi, Zainuddin, Ahmad A., Zakavi, Seyed Rasoul, Zamani, Farhad, Zambon, Sabina, Zampelas, Antonis, Elisa Zapata, Maria, Zaw, Ko Ko, Zejglicova, Kristyna, Vrkic, Tajana Zeljkovic, Zeng, Yi, Zhang, Luxia, Zhao, Dong, Zhao, Ming-Hui, Zhen, Shiqi, Zheng, Yingfeng, Zholdin, Bekbolat, Zhu, Dan, Zins, Marie, Zitt, Emanuel, Zocalo, Yanina, Zoghlami, Nada, Zuniga Cisneros, Julio., School of Medicine, ACS - Diabetes & metabolism, APH - Global Health, Pulmonology, Medical Informatics, Adult Psychiatry, Global Health, APH - Quality of Care, APH - Methodology, Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, Anesthesiology, Graduate School, and ACS - Heart failure & arrhythmias
Subjects: Male, Latin Americans, Nutrition and Disease, Epidemiology, [SDV]Life Sciences [q-bio], Medizin, BLOOD-PRESSURE, 030204 cardiovascular system & hematology, Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants, Hypertension, Prevalence, Control, Tretament, GUIDELINES, Global Health, Worldwide trends, 0302 clinical medicine, Hypertension prevalence, Voeding en Ziekte, Medicine and Health Sciences, kohonnut verenpaine, Medicine, 030212 general & internal medicine, Prevention and Control, 11 Medical and Health Sciences, ComputingMilieux_MISCELLANEOUS, education.field_of_study, food and beverages, Public Health, Global Health, Social Medicine and Epidemiology, General Medicine, Noncommunicable diseases, Period prevalence, Middle Aged, kansainvälinen vertailu, 3142 Public health care science, environmental and occupational health, 3. Good health, MIDDLE-INCOME, Pooled analysis, SYSTEMATIC ANALYSIS, INCOME COUNTRIES, ADULTS, PREVENTION, MANAGEMENT, ADHERENCE, DIAGNOSIS, Western europe, [SDE]Environmental Sciences, Hypertension/diagnosis, NCD Risk Factor Collaboration (NCD-RisC), Female, B990 Subjects Allied to Medicine not elsewhere classified, Life Sciences & Biomedicine, Adult, health-care, esiintyvyys, Central asia, Population, Nursing, 3121 Internal medicine, 03 medical and health sciences, Medicine, General & Internal, Drug Therapy, General & Internal Medicine, Life Science, Humans, ddc:610, education, Antihypertensive Agents, VLAG, Aged, Science & Technology, Antihypertensive Agents/therapeutic use, business.industry, Omvårdnad, fungi, General and internal medicine, Estados de Saúde e de Doença, Taking medication, Treatment, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Blood pressure, Faculdade de Ciências Sociais, 3121 General medicine, internal medicine and other clinical medicine, lääkehoito, 1182 Biochemistry, cell and molecular biology, business, Demography
Abstract: Background: hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. Methods: we used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. Findings: the number of people aged 30-79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306-359) million women and 317 (292-344) million men in 1990 to 626 (584-668) million women and 652 (604-698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55-62) of women and 49% (46-52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43-51) of women and 38% (35-41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20-27) for women and 18% (16-21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran. Interpretation Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings., British Heart Foundation Centre of Research Excellence Grant; World Health Organization (WHO); Abdul Latif Jameel Institute for Disease and Emergency Analytics Fellowship
Published: 2021
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31. The Distribution of Different Types of Diabetes in Childhood: A Single Center Experience

Author: Tulay Guran, Belma Haliloglu, Enes Celik, Serpil Bas, Serap Turan, Saygin Abali, Zeynep Atay, Abdullah Bereket, Fuat Bugrul, Haliloglu, Belma, Abali, Saygin, Bugrul, Fuat, Celik, Enes, Bas, Serpil, Atay, Zeynep, Guran, Tulay, Turan, Serap, Bereket, Abdullah, Haliloglu, Belma Yeditepe Univ, Fac Med, Dept Pediat Endocrinol, Istanbul, Turkey, Abali, Saygin Acibadem Univ, Fac Med, Dept Pediat Endocrinol, Istanbul, Turkey, Bereket, Abdullah Marmara Univ, Dept Pediat Endocrinol, Fac Med, Istanbul, Turkey, Bas, Serpil Necip Fazil City Hosp, Clin Pediat Endocrinol, Kahramanmaras, Turkey, Atay, Zeynep Medipol Univ, Fac Med, Dept Pediat Endocrinol, Istanbul, Turkey, Turan, Serap -- 0000-0002-5172-5402, ABALI, SAYGIN -- 0000-0001-6552-2801, and Acibadem University Dspace
Subjects: Male, Pediatrics, medicine.medical_specialty, Diabetic ketoacidosis, endocrine system diseases, Adolescent, Turkey, Endocrinology, Diabetes and Metabolism, Population, 030209 endocrinology & metabolism, Type 2 diabetes, Gene mutation, DIAGNOSIS, Maturity onset diabetes of the young, 03 medical and health sciences, MELLITUS, 0302 clinical medicine, Endocrinology, Diabetes mellitus, ADOLESCENTS, medicine, PROGRAM, Humans, 030212 general & internal medicine, education, Child, childhood, Type 1 diabetes, education.field_of_study, business.industry, nutritional and metabolic diseases, Infant, POLISH CHILDREN, medicine.disease, HNF1A, PREVALENCE, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, REGISTRY, Child, Preschool, Pediatrics, Perinatology and Child Health, ONSET, YOUNG, MODY, Original Article, Female, type 2 diabetes, business
Abstract: Objective: Type 1 diabetes (T1D) is the most common cause of diabetes in childhood but type 2 diabetes (T2D) and maturity onset diabetes of the young (MODY) are emerging as noteworthy causes of diabetes at young ages. The aim is to determine the distribution, trends and clinical features of the different types of diabetes in childhood in one tertiary center. Methods: The records of children and adolescents aged 0-18 years who were diagnosed as “diabetes/persistent hyperglycemia” between January 1999 and December 2016, were reviewed. Clinical and laboratory characteristics of the patients at diagnosis and type of diabetes were recorded. Results: Children and adolescents aged 0-18 years who were diagnosed "diabetes/persistent hyperglycemia" between January 1999 and December 2016, were reviewed. Clinical and laboratory characteristics of the patients at the diagnosis and type of diabetes were recorded.The mean ± standard deviation age of 835 patients (48.7% females) at diagnosis was 8.8±4.4 years. Eighty-four percent of the patients were diagnosed as T1D, 5.7% as T2D, 5.3% as clinical MODY and 5% as being cases of other types of diabetes. The frequency of diabetic ketoacidosis (DKA) and severe DKA in T1D were 48.4% and 11.6%, respectively. Fourteen patients (29.2%) with T2D presented with ketosis and two of them (4.2%) had DKA at diagnosis. Antibody positivity was 83.1% in T1D and 14.8% in T2D. A statistically significant increase in the frequency of T2D has clearly been demonstrated in recent years with a frequency of 1.9%, 2.4% and 7.9% in 1999-2004, 2005-2010 and 2011-2016, respectively (p
Published: 2018

32. Ex vivo and in vitro assessment of anti-inflammatory activity of seed β-conglutin proteins from Lupinus angustifolius

Author: Juan de Dios Alché, Sonia Morales-Santana, Victor Alché, José Carlos Jiménez-López, Rhonda C. Foley, Kadambot H. M. Siddique, Su Melser, Elena Lima-Cabello, Karam B. Singh, [Lima-Cabello, Elena] CSIC, Estn Expt Zaidin, Dept Biochem Cell & Mol Biol Plants, Prof Albareda 1, E-18008 Granada, Spain, [Alche, Juan D.] CSIC, Estn Expt Zaidin, Dept Biochem Cell & Mol Biol Plants, Prof Albareda 1, E-18008 Granada, Spain, [Jimenez-Lopez, Jose C.] CSIC, Estn Expt Zaidin, Dept Biochem Cell & Mol Biol Plants, Prof Albareda 1, E-18008 Granada, Spain, [Morales-Santana, Sonia] Univ Hosp San Cecilio, Biomed Res Inst Granada IBS Granada, CIBER Fragil & Hlth Aging CIBERFFS, Endocrinol Unit,Endocrinol Div, Dr Oloriz 16, E-18012 Granada, Spain, [Morales-Santana, Sonia] Univ Hosp San Cecilia, Biomed Res Inst Granada IBS Granada, Proteom Res Serv, Dr Oloriz 16, E-18012 Granada, Spain, [Foley, Rhonda C.] CSIRO, CELS, Agr & Food, 147 Underwood Ave, Wembly, WA 6014, Australia, [Singh, Karam B.] CSIRO, CELS, Agr & Food, 147 Underwood Ave, Wembly, WA 6014, Australia, [Melser, Su] Univ Bordeaux, INSERM, NeuroCtr Magendie, Team Endocannabinoids & Neuroadaptat,U1215, 146 Rue Leo Saignat, F-33076 Bordeaux, France, [Alche, Victor] Hlth Ctr Villanueva De Las Torres, Andalusian Hlth Syst, E-18539 Granada, Spain, [Siddique, Kadambot H. M.] Univ Western Australia, UWA Inst Agr, 35 Stirling Highway, Nedlands, WA 6009, Australia, [Singh, Karam B.] Univ Western Australia, UWA Inst Agr, 35 Stirling Highway, Nedlands, WA 6009, Australia, [Jimenez-Lopez, Jose C.] Univ Western Australia, UWA Inst Agr, 35 Stirling Highway, Nedlands, WA 6009, Australia, [Siddique, Kadambot H. M.] Univ Western Australia, Sch Agr & Environm, 35 Stirling Highway, Nedlands, WA 6009, Australia, [Singh, Karam B.] Univ Western Australia, Sch Agr & Environm, 35 Stirling Highway, Nedlands, WA 6009, Australia, [Jimenez-Lopez, Jose C.] Univ Western Australia, Sch Agr & Environm, 35 Stirling Highway, Nedlands, WA 6009, Australia, European Research Program MARIE CURIE, Spanish Ministry of Economy, Industry and Competitiveness, Ministerio de Economía, Industria y Competitividad (España), Consejo Superior de Investigaciones Científicas (España), and European Commission
Subjects: 0301 basic medicine, Chemokine, chemokine CCL5, medicine.drug_class, beta-conglutins, Activation, Medicine (miscellaneous), 030209 endocrinology & metabolism, Anti-inflammatory proteins, Lupinus angustifolius, Pharmacology, Type-1, Anti-inflammatory, β-conglutins, Nitric oxide, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Nutraceutical, Nitric-oxide, Functional food, IL-1 beta, medicine, TX341-641, Alpha, Nutrition and Dietetics, biology, Nutrition. Foods and food supply, Chemistry, biology.organism_classification, In vitro, 3. Good health, Islet inflammation, iNOS, 030104 developmental biology, Vicilin, IL-1β, biology.protein, Cytokines, Antioxidant, Ex vivo, Food Science
Abstract: The development of functional food ingredients using legume seed proteins has potential for nutraceutical use. We purified recombinant β-conglutin proteins (rβ1 to rβ4, and rβ6) from narrow-leafed lupin using affinity–chromatography, and evaluated their anti-inflammatory activity using ex vivo and in vitro systems. rβ1, rβ3, and rβ6 produced lower levels of pro-inflammatory mediators such as nitric oxide (about –34.0–fold in all cases), iNOS mRNA (−7.15, −7.97, −7.41–fold), interleukin 1β (−12.05, −11.64, −12.16–fold), chemokine CCL5 (−16.0, −18.0, −19.0–fold), and cytokines including TNF-α INF-γ IL-1β IL-2, IL-6, IL-8, and IL-12 (β1: −28, −100, −8, −2, −49, −45, −127–fold; β3: −22, −400, −9, −3, −33, −10, −2.54–fold; β6: −72, −122, −11, −3, −2000, −13, −338–fold). These results suggest that the β1, β3, and β6 conglutins have potential as functional food components in nutraceuticals and that can provide alternative therapies for the prevention and treatment of inflammatory-related diseases., This work was partially supported by the European Research Program MARIE CURIE (FP7-PEOPLE-24 2011-IOF) through the grant ref. number PIOF-GA-2011-301550 to JCJ-L, KBS and JDA. JCJ-L thanks the Spanish Ministry of Economy, Industry and Competitiveness for the grant ref. RYC-2014-16536 (Ramon y Cajal Research Program), and the grant ref. BFU2016-77243-P.
Published: 2018
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33. Association between dopamine and somatostatin receptor expression and pharmacological response to somatostatin analogues in acromegaly

Author: Raúl M. Luque, Mari C Vázquez-Borrego, Miguel A. Japón, Elena Dios, Alvaro Flores-Martínez, David A. Cano, Noelia Gros-Herguido, Justo P. Castaño, Eva Venegas-Moreno, Esther Rivero-Cortés, Alfonso Soto-Moreno, Ainara Madrazo-Atutxa, [Venegas-Moreno, Eva] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Unidad Gest Endocrinol Nutr,Inst Biomed Sevilla I, Seville, Spain, [Dios, Elena] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Unidad Gest Endocrinol Nutr,Inst Biomed Sevilla I, Seville, Spain, [Gros-Herguido, Noelia] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Unidad Gest Endocrinol Nutr,Inst Biomed Sevilla I, Seville, Spain, [Flores-Martinez, Alvaro] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Unidad Gest Endocrinol Nutr,Inst Biomed Sevilla I, Seville, Spain, [Madrazo-Atutxa, Ainara] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Unidad Gest Endocrinol Nutr,Inst Biomed Sevilla I, Seville, Spain, [Cano, David A.] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Unidad Gest Endocrinol Nutr,Inst Biomed Sevilla I, Seville, Spain, [Soto-Moreno, Alfonso] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Unidad Gest Endocrinol Nutr,Inst Biomed Sevilla I, Seville, Spain, [Vazquez-Borrego, Mari C.] Univ Cordoba, Agrifood Campus Int Excellence CeiA3, CIBER Physiopathol Obes & Nutr CIBERobn,Dept Cell, Maimonides Inst Biomed Res Cordoba IMIBIC,Rein So, Cordoba, Spain, [Rivero-Cortes, Esther] Univ Cordoba, Agrifood Campus Int Excellence CeiA3, CIBER Physiopathol Obes & Nutr CIBERobn,Dept Cell, Maimonides Inst Biomed Res Cordoba IMIBIC,Rein So, Cordoba, Spain, [Luque, Raul M.] Univ Cordoba, Agrifood Campus Int Excellence CeiA3, CIBER Physiopathol Obes & Nutr CIBERobn,Dept Cell, Maimonides Inst Biomed Res Cordoba IMIBIC,Rein So, Cordoba, Spain, [Castano, Justo P.] Univ Cordoba, Agrifood Campus Int Excellence CeiA3, CIBER Physiopathol Obes & Nutr CIBERobn,Dept Cell, Maimonides Inst Biomed Res Cordoba IMIBIC,Rein So, Cordoba, Spain, [Japon, Miguel A.] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Dept Pathol,Inst Biomed Sevilla IBIS, Seville, Spain, ISCIII-Subdireccion General de Evaluacion y Fomento de la Investigacion, Fondos FEDER, Novartis Oncology Spain, Junta de Andalucia, MINECO, CIBERobn (CIBER is an initiative of Instituto de Salud Carlos III, Ministerio de Sanidad, Servicios Sociales e Igualdad, Spain), Novartis Oncology, Andalusian and Spanish Societies of Endocrinology and Nutrition (SAEDYN), Andalusian and Spanish Societies of Endocrinology and Nutrition (SEEN), and 'Nicolas Monardes' programme of the Andalusian Ministry of Health
Subjects: Male, Octreotide-lar, Gene Expression, pituitary adenoma, Receptors, Dopamine, In-vitro, 0302 clinical medicine, Subtype 2a, dopamine receptor, Protein Isoforms, Somatostatin receptor 2, Pituitary-adenomas, Somatostatin receptor 1, Receptors, Somatostatin, Receptor, Somatotroph adenomas, somatostatin analogues, Reverse Transcriptase Polymerase Chain Reaction, Somatostatin receptor, Middle Aged, Immunohistochemistry, somatostatin receptor, Somatostatin, Biochemical response, Dopamine receptor, 030220 oncology & carcinogenesis, Molecular Medicine, Original Article, Female, Adenoma, Adult, medicine.medical_specialty, Monoclonal-antibodies, 030209 endocrinology & metabolism, 03 medical and health sciences, Pituitary adenoma, Internal medicine, Acromegaly, medicine, Humans, Retrospective Studies, Tumor-cells, business.industry, Original Articles, Cell Biology, medicine.disease, Endocrinology, acromegaly, Clinical-response, Growth Hormone-Secreting Pituitary Adenoma, Aggressive features, business
Abstract: Acromegaly is a hormonal disorder resulting from excessive growth hormone (GH) secretion frequently produced by pituitary adenomas and consequent increase in insulin‐like growth factor 1 (IGF‐I). Elevated GH and IGF‐I levels result in a wide range of somatic, cardiovascular, endocrine, metabolic and gastrointestinal morbidities. Somatostatin analogues (SSAs) form the basis of medical therapy for acromegaly and are currently used as first‐line treatment or as second‐line therapy in patients undergoing unsuccessful surgery. However, a considerable percentage of patients do not respond to SSAs treatment. Somatostatin receptors (SSTR1‐5) and dopamine receptors (DRD1‐5) subtypes play critical roles in the regulation of hormone secretion. These receptors are considered important pharmacological targets to inhibit hormone oversecretion. It has been proposed that decreased expression of SSTRs may be associated with poor response to SSAs. Here, we systematically examine SSTRs and DRDs expression in human somatotroph adenomas by quantitative PCR. We observed an association between the response to SSAs treatment and DRD4, DRD5, SSTR1 and SSTR2 expression. We also examined SSTR expression by immunohistochemistry and found that the immunohistochemical detection of SSTR2 in particular might be a good predictor of response to SSAs.
Published: 2017
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34. Octreotide and pasireotide (dis)similarly inhibit pituitary tumor cells in vitro

Author: María Ángeles Gálvez, Alejandro Ibáñez-Costa, Silvia Maraver-Selfa, Juan Garcia-Arnes, Mari C Vázquez-Borrego, Alfonso Soto-Moreno, Miguel A. Japón, Inmaculada González-Molero, Andrés de la Riva, Herbert A. Schmid, Esther Rivero-Cortés, Inmaculada Gavilan-Villarejo, Luis Jiménez-Reina, Eva Venegas-Moreno, Raúl M. Luque, Miguel Angel Arraez, Manuel D. Gahete, Justo P. Castaño, [Ibanez-Costa, Alejandro] Inst Maimonides Invest Biomed Cordoba IMIBIC, Cordoba, Spain, [Rivero-Cortes, Esther] Inst Maimonides Invest Biomed Cordoba IMIBIC, Cordoba, Spain, [Vazquez-Borrego, Mari C.] Inst Maimonides Invest Biomed Cordoba IMIBIC, Cordoba, Spain, [Gahete, Manuel D.] Inst Maimonides Invest Biomed Cordoba IMIBIC, Cordoba, Spain, [Jimenez-Reina, Luis] Inst Maimonides Invest Biomed Cordoba IMIBIC, Cordoba, Spain, [Galvez, Maria A.] Inst Maimonides Invest Biomed Cordoba IMIBIC, Cordoba, Spain, [Luque, Raul M.] Inst Maimonides Invest Biomed Cordoba IMIBIC, Cordoba, Spain, [Castano, Justo P.] Inst Maimonides Invest Biomed Cordoba IMIBIC, Cordoba, Spain, [Ibanez-Costa, Alejandro] Univ Cordoba, Dept Cell Biol Physiol & Immunol, Cordoba, Spain, [Rivero-Cortes, Esther] Univ Cordoba, Dept Cell Biol Physiol & Immunol, Cordoba, Spain, [Vazquez-Borrego, Mari C.] Univ Cordoba, Dept Cell Biol Physiol & Immunol, Cordoba, Spain, [Gahete, Manuel D.] Univ Cordoba, Dept Cell Biol Physiol & Immunol, Cordoba, Spain, [Luque, Raul M.] Univ Cordoba, Dept Cell Biol Physiol & Immunol, Cordoba, Spain, [Castano, Justo P.] Univ Cordoba, Dept Cell Biol Physiol & Immunol, Cordoba, Spain, [Ibanez-Costa, Alejandro] Hosp Univ Reina Sofia, Cordoba, Spain, [Rivero-Cortes, Esther] Hosp Univ Reina Sofia, Cordoba, Spain, [Vazquez-Borrego, Mari C.] Hosp Univ Reina Sofia, Cordoba, Spain, [Gahete, Manuel D.] Hosp Univ Reina Sofia, Cordoba, Spain, [Galvez, Maria A.] Hosp Univ Reina Sofia, Cordoba, Spain, [Luque, Raul M.] Hosp Univ Reina Sofia, Cordoba, Spain, [Castano, Justo P.] Hosp Univ Reina Sofia, Cordoba, Spain, [Ibanez-Costa, Alejandro] CIBER Fisiopatol Obesidad & Nutr CIBERObn, Cordoba, Spain, [Rivero-Cortes, Esther] CIBER Fisiopatol Obesidad & Nutr CIBERObn, Cordoba, Spain, [Vazquez-Borrego, Mari C.] CIBER Fisiopatol Obesidad & Nutr CIBERObn, Cordoba, Spain, [Gahete, Manuel D.] CIBER Fisiopatol Obesidad & Nutr CIBERObn, Cordoba, Spain, [Luque, Raul M.] CIBER Fisiopatol Obesidad & Nutr CIBERObn, Cordoba, Spain, [Castano, Justo P.] CIBER Fisiopatol Obesidad & Nutr CIBERObn, Cordoba, Spain, [Jimenez-Reina, Luis] Univ Cordoba, Dept Morphol Sci, Cordoba, Spain, [Venegas-Moreno, Eva] Hosp Univ Virgen del Rocio, Inst Biomed Sevilla IBIS, Metab & Nutr Unit, Seville, Spain, [Soto-Moreno, Alfonso] Hosp Univ Virgen del Rocio, Inst Biomed Sevilla IBIS, Metab & Nutr Unit, Seville, Spain, [de la Riva, Andres] Hosp Univ Reina Sofia, Serv Neurosurg, Cordoba, Spain, [Angel Arraez, Miguel] Carlos Haya Hosp, Neurosurg Dept, Malaga, Spain, [Gonzalez-Molero, Inmaculada] Carlos Haya Hosp, Dept Endocrinol & Nutr, Malaga, Spain, [Antonio Garcia-Arnes, Juan] Carlos Haya Hosp, Dept Endocrinol & Nutr, Malaga, Spain, [Schmid, Herbert A.] Novartis Pharma AG, Novartis Inst Biomed Res, Oncol, CH-4057 Basel, Switzerland, [Maraver-Selfa, Silvia] Hosp Clin Univ Virgen de la Victoria, Serv Endocrinol & Nutr, Malaga, Spain, [Gavilan-Villarejo, Inmaculada] Hosp Univ Puerta del Mar, Endocrinol & Nutr Unit, Cadiz, Spain, [Japon, Miguel A.] Hosp Univ Virgen del Rocio, Dept Pathol, Seville, Spain, [Galvez, Maria A.] Hosp Univ Reina Sofia, Serv Endocrinol & Nutr, Cordoba, Spain, Junta de Andalucia, Ministerio de Economia y Competitividad, Gobierno de Espana, Proyectos de Investigacion en Salud FIS - Instituto de Salud Carlos III, Instituto de Salud Carlos III, Ministerio de Sanidad, Servicios Sociales e Igualdad 'CIBERobn', and Instituto de Salud Carlos III, Ministerio de Sanidad, Servicios Sociales e Igualdad 'Sara Borrell Program' Ayuda Merck Serono
Subjects: Male, 0301 basic medicine, Endocrinology, Diabetes and Metabolism, Somatostatin analog som230, Octreotide, pituitary adenoma, Pituitary neoplasm, pituitary, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Tumor Cells, Cultured, Protein Isoforms, Somatostatin receptor 2, Receptors, Somatostatin, Cells, Cultured, Chemistry, Medical-treatment, Adenomas, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, ACTH-Secreting Pituitary Adenoma, Somatostatin, Pituitary Gland, Female, Acth release, medicine.drug, Adenoma, medicine.medical_specialty, Antineoplastic Agents, Hormonal, Cell Survival, 030209 endocrinology & metabolism, somatostatin, 03 medical and health sciences, Quantitative-analysis, Pituitary adenoma, Internal medicine, medicine, cell signaling, Humans, Pituitary Neoplasms, Prolactinoma, Calcium Signaling, Gene-expression levels, Growth-hormone, Pituitary tumors, Receptor subtypes, medicine.disease, Pasireotide, stomatognathic diseases, 030104 developmental biology, Drug Resistance, Neoplasm, gene expression, Cushings-disease, Aggressive features, Growth Hormone-Secreting Pituitary Adenoma
Abstract: Somatostatin analogs (SSA) are the mainstay of pharmacological treatment for pituitary adenomas. However, some patients escape from therapy with octreotide, a somatostatin receptor 2 (sst2)-preferring SSA, and pasireotide, a novel multi-sst-preferring SSA, may help to overcome this problem. It has been proposed that correspondence between sst1-sst5 expression pattern and SSA-binding profile could predict patient’s response. To explore the cellular/molecular features associated with octreotide/pasireotide response, we performed a parallel comparison of their in vitro effects, evaluating sst1-sst5 expression, intracellular Ca2+ signaling ([Ca2+]i), hormone secretion and cell viability, in a series of 85 pituitary samples. Somatotropinomas expressed sst5>sst2, yet octreotide reduced [Ca2+]i more efficiently than pasireotide, while both SSA similarly decreased growth hormone release/expression and viability. Corticotropinomas predominantly expressed sst5, but displayed limited response to pasireotide, while octreotide reduced functional endpoints. Non-functioning adenomas preferentially expressed sst3 but, surprisingly, both SSA increased cell viability. Prolactinomas mainly expressed sst1 but were virtually unresponsive to SSA. Finally, both SSA decreased [Ca2+]i in normal pituitaries. In conclusion, both SSA act in vitro on pituitary adenomas exerting both similar and distinct effects; however, no evident correspondence was found with the sst1-sst5 profile. Thus, it seems plausible that additional factors, besides the simple abundance of a given sst, critically influence the SSA response.
Published: 2016
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35. Coronary Heart Disease, Peripheral Arterial Disease, and Stroke in Familial Hypercholesterolaemia

Author: Perez de Isla, L, Alonso, R, Mata, N, Saltijeral, A, Muniz, O, Rubio-Marin, P, Diaz-Diaz, J, Fuentes, F, de Andres, R, Zambon, D, Galiana, J, Piedecausa, M, Aguado, R, Mosquera, D, Vidal, J, Ruiz, E, Manjon, L, Mauri, M, Padro, T, Miramontes, J, Mata, P, SAFEHEART Investigators, [Perez de Isla, Leopoldo] Hosp Clin San Carlos, Dept Cardiol, IDISSC, Madrid, Spain, [Perez de Isla, Leopoldo] Fdn Hipercolesterolemia Familiar, C Gen Alvarez de Castro 14, Madrid 28010, Spain, [Alonso, Rodrigo] Fdn Hipercolesterolemia Familiar, C Gen Alvarez de Castro 14, Madrid 28010, Spain, [Mata, Nelva] Fdn Hipercolesterolemia Familiar, C Gen Alvarez de Castro 14, Madrid 28010, Spain, [Saltijeral, Adriana] Fdn Hipercolesterolemia Familiar, C Gen Alvarez de Castro 14, Madrid 28010, Spain, [Mata, Pedro] Fdn Hipercolesterolemia Familiar, C Gen Alvarez de Castro 14, Madrid 28010, Spain, [Alonso, Rodrigo] Clin Las Condes, Santiago, Chile, [Mata, Nelva] Madrid Hlth Author, Dept Epidemiol, Madrid, Spain, [Saltijeral, Adriana] Hosp Tajo, Dept Cardiol, Madrid, Spain, [Muniz, Ovidio] Hosp Virgen del Rocio, Dept Internal Med, Seville, Spain, [Rubio-Marin, Patricia] Hosp SAS Jerez Frontera, Dept Internal Med, Cadiz, Spain, [Diaz-Diaz, Jose L.] Hosp Abente & Lago, Dept Internal Med, La Coruna, Spain, [Fuentes, Francisco] Hosp Univ Reina Sofia, Dept Internal Med, Cordoba, Spain, [de Andres, Raimundo] Fdn Jimenez Diaz, Dept Internal Med, Madrid, Spain, [Zambon, Daniel] Hosp Clin Barcelona, Serv Endocrinol, Lipid Clin, Barcelona, Spain, [Galiana, Jesus] Hosp Univ Ciudad Real, Dept Internal Med, Ciudad Real, Spain, [Piedecausa, Mar] Hosp Univ Elche, Dept Internal Med, Alicante, Spain, [Alonso, Rodrigo] Hosp Gen Leon, Dept Endocrinol, Leon, Spain, [Mosquera, Daniel] Hosp San Pedro, Dept Internal Med, Logrono, Spain, [Vidal, Jose I.] Hosp Univ Lugo, Dept Endocrinol, Lugo, Spain, [Ruiz, Enrique] Hosp Univ Burgos, Dept Endocrinol, Burgos, Spain, [Manjon, Laura] Hosp Gijon, Dept Endocrinol, Asturias, Spain, [Mauri, Marta] Hosp Terrassa, Dept Internal Med, Barcelona, Spain, [Padro, Teresa] IIB St Pau, Inst Catalan Ciencias Cardiovasc, Barcelona, Spain, [Miramontes, Jose P.] Univ Hosp, Dept Internal Med, Salamanca, Spain, Fundacion Hipercolesterolemia Familiar, and Instituto de Salud Carlos III
Subjects: Male, Heredity, Arterial disease, Coronary Disease, Comorbidity, Disease, Familial hypercholesterolemia, 030204 cardiovascular system & hematology, coronary disease, 0302 clinical medicine, Risk Factors, Prevalence, genetics, Prospective Studies, Registries, 030212 general & internal medicine, Age of Onset, Stroke, Molecular Epidemiology, education.field_of_study, hypercholesterolemia, Smoking, Middle Aged, stroke, Pedigree, Peripheral, Phenotype, Apolipoprotein B-100, Female, Cardiology and Cardiovascular Medicine, Cohort study, Adult, Risk, Heterozygote, medicine.medical_specialty, peripheral vascular diseases, Population, Risk Assessment, Hyperlipoproteinemia Type II, Peripheral Arterial Disease, 03 medical and health sciences, Sex Factors, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, education, Aged, States, business.industry, Statins, medicine.disease, Coronary heart disease, Receptors, LDL, Spain, Case-Control Studies, Mutation, Physical therapy, business
Abstract: Objective— Heterozygous familial hypercholesterolemia (FH) is the most common premature atherosclerotic cardiovascular disease (ASCVD)–related monogenic disorder, and it is associated with ischemic heart disease. There is limited information whether FH increases the risk of peripheral arterial and cerebrovascular disease. Our aim was to analyze ASCVD prevalence and characteristics in different arterial territories in a large FH population, to compare them with an unaffected control population and to determine which factors are associated to ASCVD. Approach and Results— SAFEHEART (Spanish Familial Hypercholesterolaemia Cohort Study) is an ongoing registry of molecularly defined patients with heterozygous FH in Spain. ASCVD in the different arterial territories was analyzed, as well as individual characteristics, genetic variables, and lipid-lowering therapies. The study recruited 4132 subjects (3745 ≥18 years); 2,752 of those enrolled were molecularly diagnosed FH cases. Median age was 44.0 years (45.9% men) and 40 years (46.6% men) in FH patients and unaffected relatives ( P P P 50 mg/dL were independently associated with ASCVD. Conclusions— The prevalence of ASCVD is higher, and the involvement of the arterial territories is different in FH patients when compared with their unaffected relatives. Age, male sex, increased body mass index, hypertension, type 2 diabetes mellitus, smoking habit, and lipoprotein(a) >50 mg/dL were independently associated to ASCVD. Clinical Trial Registration— URL: https://www.clinicaltrials.gov . Unique identifier: NCT02693548.
Published: 2016
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36. Clinical and Genetic Characteristics, Management and Long-Term Follow-Up of Turkish Patients with Congenital Hyperinsulinism

Author: Sarah E. Flanagan, Ayşe Nurcan Cebeci, Ayla Güven, Sian Ellard, GUVEN, AYLA -- 0000-0002-2026-1326, Ellard, Sian -- 0000-0002-7620-5526, Flanagan, Sarah -- 0000-0002-8670-6340, and [Guven, Ayla] Goztepe Training & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey -- [Guven, Ayla] Amasya Univ, Fac Med, Dept Pediat, Amasya, Turkey -- [Cebeci, Ayse Nurcan] Derince Training & Res Hosp, Clin Pediat Endocrinol, Kocaeli, Turkey -- [Ellard, Sian -- Flanagan, Sarah E.] Univ Exeter, Sch Med, Inst Biomed & Clin Sci, Exeter, Devon, England
Subjects: medicine.medical_specialty, Pediatrics, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 030209 endocrinology & metabolism, Hypoglycemia, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Hyperinsulinism, Diabetes mellitus, medicine, 030212 general & internal medicine, Mutation, business.industry, Gestational age, Retrospective cohort study, medicine.disease, ATP-sensitive potassium (K-ATP) channel, 3. Good health, Surgery, diabetes mellitus, Pediatrics, Perinatology and Child Health, Pancreatectomy, Cohort, Congenital hyperinsulinism, pancreatectomy, business
Abstract: WOS: 000378169400012 PubMed ID: 26758964 Objective: Mutations in the K-ATP channel genes is the most common cause of congenital hyperinsulinism (CHI) of infancy. Our aim was to report the clinical and genetic characteristics, treatment modalities, and long-term prognosis of patients with CHI. Methods: Clinical and biochemical findings, operation procedures, and results of genetic analysis were retrospectively evaluated in 22 CHI patients from two pediatric endocrine centers in Turkey. Results: Seven of the patients were born large for gestational age. Hypoglycemia was diagnosed within the first 24 hours of life in 9 patients and treatment with diazoxide (n=21) and/or somatostatin (n=8) had been attempted. Seven patients (31.8%) were unresponsive to medical treatment and underwent pancreatectomy. Histological examination of the pancreas confirmed diffuse disease in 6 patients. Diabetes developed in 3 patients following pancreatectomy (10 years, 2.5 years, and immediately after operation). The remaining four patients had neither recurrence of CHI nor of diabetes during the 3.67 +/- 0.7 years of follow-up. Sequence analysis identified mutations in 12 out of 19 patients (63%). Mutations in the ABCC8 gene were the most common finding and were found in 6 out of 7 patients who underwent pancreatectomy. Other mutations included a paternally inherited KCNJ11 mutation, a homozygous HADH mutation, and a heterozygous GLUD1 mutation. Conclusion: Mutations in the ABCC8 gene were the most common cause of CHI in our cohort. These mutations were identified in 85% of patients who underwent pancreatectomy. The development of diabetes mellitus after pancreatectomy may occur at any age and these patients should be screened regularly. Medical Research Council; Wellcome Trust; Royal Society [105636/Z/14/Z] The genetic analysis reported in this study was supported by a grant from the Medical Research Council. SF has a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (Grant Number 105636/Z/14/Z).
Published: 2016
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37. Sildenafil Activates Browning of White Adipose and Improves Insulin Sensitivity

Author: Xiang Guang-da, Director of Endocrinol Dept.
Published: 2016

38. Chronic Cold Acclimation Stimulates the Browning of Subcutaneous White Adipose in Patients With Type 2 Diabetes Mellitus

Author: Xiang Guang-da, Director of Endocrinol Dept.
Published: 2016

39. Metformin Induces a Dietary Restriction-like State in Human

Author: Xiang Guang-da, Director of Endocrinol Dept.
Published: 2016

40. Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: A pooled analysis of 1018 population-based measurement studies with 88.6 million participants

Author: Yiallouros, Panayiotis K., Escobedo-de la Peña, Jorge, Zhou, Bin, Bentham, James, Di Cesare, Mariachiara, Bixby, Honor, Danaei, Goodarz, Hajifathalian, Kaveh, Taddei, Cristina, Carrillo-Larco, Rodrigo M., Djalalinia, Shirin, Khatibzadeh, Shahab, Lugero, Charles, Peykari, Niloofar, Zhang, Wan Zhu, Bennett, James, Bilano, Ver, Stevens, Gretchen A., Cowan, Melanie J., Riley, Leanne M., Chen, Zhengming, Hambleton, Ian R., Jackson, Rod T., Kengne, Andre Pascal, Khang, Young-Ho, Laxmaiah, Avula, Liu, Jing, Malekzadeh, Reza, Neuhauser, Hannelore K., Sorić, Maroje, Starc, Gregor, Sundström, Johan, Woodward, Mark, Ezzati, Majid, Abarca-Gómez, Leandra, Abdeen, Ziad A., Abu-Rmeileh, Niveen M., Acosta-Cazares, Benjamin, Adams, Robert J., Aekplakorn, Wichai, Afsana, Kaosar, Aguilar-Salinas, Carlos A., Agyemang, Charles, Ahmad, Noor Ani, Ahmadvand, Alireza, Ahrens, Wolfgang, Ajlouni, Kamel, Akhtaeva, Nazgul, Al-Raddadi, Rajaa, Ali, Mohamed M., Ali, Osman, Alkerwi, Ala'a, Aly, Eman, Amarapurkar, Deepak N., Amouyel, Philippe, Amuzu, Antoinette, Andersen, Lars Bo, Anderssen, Sigmund A., Ängquist, Lars H., Anjana, Ranjit Mohan, Ansong, Daniel, Aounallah-Skhiri, Hajer, Araújo, Joana, Ariansen, Inger, Aris, Tahir, Arlappa, Nimmathota, Arveiler, Dominique, Aryal, Krishna K., Aspelund, Thor, Assah, Felix K., Assunção, Maria Cecília F., Avdicová, Mária, Azevedo, Ana, Azizi, Fereidoun, Babu, Bontha V., Bahijri, Suhad, Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Bandosz, Piotr, Banegas, José R., Barbagallo, Carlo M., Barceló, Alberto, Barkat, Amina, Barros, Aluisio J. D., Barros, Mauro V., Bata, Iqbal, Batieha, Anwar M., Batyrbek, Assembekov, Baur, Louise A., Beaglehole, Robert, Romdhane, Habiba Ben, Benet, Mikhail, Benson, Lowell S., Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Bettiol, Heloisa, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K., Bi, Yufang, Bikbov, Mukharram, Bista, Bihungum, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B., Björkelund, Cecilia, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boeing, Heiner, Boggia, Jose G., Boissonnet, Carlos P., Bongard, Vanina, Borchini, Rossana, Bovet, Pascal, Braeckman, Lutgart, Brajkovich, Imperia, Branca, Francesco, Breckenkamp, Juergen, Brenner, Hermann, Brewster, Lizzy M., Bruno, Graziella, Bueno-de-Mesquita, H. B(as), Bugge, Anna, Burns, Con, Bursztyn, Michael, de León, Antonio Cabrera, Cacciottolo, Joseph, Cai, Hui, Cameron, Christine, Can, Günay, Cândido, Ana Paula C., Capuano, Vincenzo, Cardoso, Viviane C., Carlsson, Axel C., Carvalho, Maria J., Casanueva, Felipe F., Casas, Juan-Pablo, Caserta, Carmelo A., Chamukuttan, Snehalatha, Chan, Angelique W., Chan, Queenie, Chaturvedi, Himanshu K., Chaturvedi, Nishi, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Shuohua, Cheng, Ching-Yu, Dekkaki, Imane Cherkaoui, Chetrit, Angela, Chiolero, Arnaud, Chiou, Shu-Ti, Chirita-Emandi, Adela, Chirlaque, María-Dolores, Cho, Belong, Cho, Yumi, Christofaro, Diego G., Chudek, Jerzy, Cifkova, Renata, Cinteza, Eliza, Claessens, Frank, Clays, Els, Concin, Hans, Cooper, Cyrus, Cooper, Rachel, Coppinger, Tara C., Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L., Crujeiras, Ana B., Cruz, Juan J., D'Arrigo, Graziella, d'Orsi, Eleonora, Dallongeville, Jean, Damasceno, Albertino, Dankner, Rachel, Dantoft, Thomas M., Dauchet, Luc, Davletov, Kairat, De Backer, Guy, De Bacquer, Dirk, de Gaetano, Giovanni, De Henauw, Stefaan, de Oliveira, Paula Duarte, De Smedt, Delphine, Deepa, Mohan, Dehghan, Abbas, Delisle, Hélène, Deschamps, Valérie, Dhana, Klodian, Di Castelnuovo, Augusto F., Dias-da-Costa, Juvenal Soares, Diaz, Alejandro, Dickerson, Ty T., Do, Ha T. P., Donfrancesco, Chiara, Donoso, Silvana P., Döring, Angela, Dorobantu, Maria, Doua, Kouamelan, Drygas, Wojciech, Dulskiene, Virginija, Džakula, Aleksandar, Dzerve, Vilnis, Dziankowska-Zaborszczyk, Elzbieta, Eggertsen, Robert, Ekelund, Ulf, El Ati, Jalila, Elliott, Paul, Elosua, Roberto, Erasmus, Rajiv T., Erem, Cihangir, Eriksen, Louise, Eriksson, Johan G., Evans, Alun, Faeh, David, Fall, Caroline H., Farzadfar, Farshad, Felix-Redondo, Francisco J., Ferguson, Trevor S., Fernandes, Romulo A., Fernández-Bergés, Daniel, Ferrante, Daniel, Ferrari, Marika, Ferreccio, Catterina, Ferrieres, Jean, Finn, Joseph D., Fischer, Krista, Föger, Bernhard, Foo, Leng Huat, Forslund, Ann-Sofie, Forsner, Maria, Fouad, Heba M., Francis, Damian K., do Carmo Franco, Maria, Franco, Oscar H., Frontera, Guillermo, Fuchs, Flavio D., Fuchs, Sandra C., Fujita, Yuki, Furusawa, Takuro, Gaciong, Zbigniew, Galvano, Fabio, Garcia-de-la-Hera, Manoli, Gareta, Dickman, Garnett, Sarah P., Gaspoz, Jean-Michel, Gasull, Magda, Gates, Louise, Geleijnse, Johanna M., Ghasemian, Anoosheh, Ghimire, Anup, Giampaoli, Simona, Gianfagna, Francesco, Gill, Tiffany K., Giovannelli, Jonathan, Goldsmith, Rebecca A., Gonçalves, Helen, Gonzalez-Gross, Marcela, González-Rivas, Juan P., Gorbea, Mariano Bonet, Gottrand, Frederic, Graff-Iversen, Sidsel, Grafnetter, Dušan, Grajda, Aneta, Grammatikopoulou, Maria G., Gregor, Ronald D., Grodzicki, Tomasz, Grøntved, Anders, Grosso, Giuseppe, Gruden, Gabriella, Grujic, Vera, Gu, Dongfeng, Guan, Ong Peng, Gudmundsson, Elias F., Gudnason, Vilmundur, Guerrero, Ramiro, Guessous, Idris, Guimaraes, Andre L., Gulliford, Martin C., Gunnlaugsdottir, Johanna, Gunter, Marc, Gupta, Prakash C., Gupta, Rajeev, Gureje, Oye, Gurzkowska, Beata, Gutierrez, Laura, Gutzwiller, Felix, Hadaegh, Farzad, Halkjær, Jytte, Hardy, Rebecca, Hari Kumar, Rachakulla, Hata, Jun, Hayes, Alison J., He, Jiang, He, Yuna, Elisabeth, Marleen, Henriques, Ana, Cadena, Leticia Hernandez, Herrala, Sauli, Heshmat, Ramin, Hihtaniemi, Ilpo Tapani, Ho, Sai Yin, Ho, Suzanne C., Hobbs, Michael, Hofman, Albert, Dinc, Gonul Horasan, Horimoto, Andrea R. 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Ofra, Kamaruddin, Nor Azmi, Karki, Khem B, Kasaeian, Amir, Katz, Joanne, Kauhanen, Jussi, Kaur, Prabhdeep, Kavousi, Maryam, Kazakbaeva, Gyulli, Keil, Ulrich, Boker, Lital Keinan, Keinänen-Kiukaanniemi, Sirkka, Kelishadi, Roya, Kemper, Han C G, Kengne, Andre P, Kerimkulova, Alina, Kersting, Mathilde, Key, Timothy, Khader, Yousef Saleh, Khalili, Davood, Khateeb, Mohammad, Khaw, Kay-Tee, Kiechl-Kohlendorfer, Ursula, Kiechl, Stefan, Killewo, Japhet, Kim, Jeongseon, Kim, Yeon-Yong, Klumbiene, Jurate, Knoflach, Michael, Kolle, Elin, Kolsteren, Patrick, Korrovits, Paul, Koskinen, Seppo, Kouda, Katsuyasu, Kowlessur, Sudhir, Koziel, Slawomir, Kriemler, Susi, Kristensen, Peter Lund, Krokstad, Steinar, Kromhout, Daan, Kruger, Herculina S, Kubinova, Ruzena, Kuciene, Renata, Kuh, Diana, Kujala, Urho M, Kulaga, Zbigniew, Krishna Kumar, R, Kurjata, Pawel, Kusuma, Yadlapalli S, Kuulasmaa, Kari, Kyobutungi, Catherine, Laatikainen, Tiina, Lachat, Carl, Lam, Tai Hing, Landrove, Orlando, Lanska, Vera, 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Si-Ramlee, Khairil, Siantar, Rosalynn, Sibai, Abla M, Santos Silva, Diego Augusto, Simon, Mary, Simons, Judith, Simons, Leon A, Sjöström, Michael, Skovbjerg, Sine, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemyslaw, Smeeth, Liam, Smith, Margaret C, Snijder, Marieke B, So, Hung-Kwan, Sobngwi, Eugène, Söderberg, Stefan, Solfrizzi, Vincenzo, Sonestedt, Emily, Song, Yi, Sørensen, Thorkild I A, Soric, Maroje, Jérome, Charles Sossa, Soumare, Aicha, Staessen, Jan A, Stathopoulou, Maria G, Stavreski, Bill, Steene-Johannessen, Jostein, Stehle, Peter, Stein, Aryeh D, Stergiou, George S, Stessman, Jochanan, Stieber, Jutta, Stöckl, Dori, Stocks, Tanja, Stokwiszewski, Jakub, Stronks, Karien, Strufaldi, Maria Wany, Sun, Chien-An, Sung, Yn-Tz, Suriyawongpaisal, Paibul, Sy, Rody G, Shyong Tai, E, Tammesoo, Mari-Lii, Tamosiunas, Abdona, Tan, Eng Joo, Tang, Xun, Tanser, Frank, Tao, Yong, Tarawneh, Mohammed Rasoul, Tarqui-Mamani, Carolina B, Tautu, Oana-Florentina, Taylor, Anne, Theobald, Holger, Theodoridis, Xenophon, Thijs, Lutgarde, Thuesen, Betina H, Tjonneland, Anne, Tolonen, Hanna K, Tolstrup, Janne S, Topbas, Murat, Topór-Madry, Roman, Tormo, María José, Torrent, Matie, Traissac, Pierre, Trichopoulos, Dimitrio, Trichopoulou, Antonia, Trinh, Oanh T H, Trivedi, Atul, Tshepo, Lechaba, Tulloch-Reid, Marshall K, Tullu, Fikru, Tuomainen, Tomi-Pekka, Tuomilehto, Jaakko, Turley, Maria L, Tynelius, Per, Tzourio, Christophe, Ueda, Peter, Ugel, Eunice E, Ulmer, Hanno, Uusitalo, Hannu M T, Valdivia, Gonzalo, Valvi, Damaskini, van der Schouw, Yvonne T, Van Herck, Koen, Van Minh, Hoang, van Rossem, Lenie, Van Schoor, Natasja M, van Valkengoed, Irene G M, Vanderschueren, Dirk, Vanuzzo, Diego, Vatten, Lar, Vega, Toma, Velasquez-Melendez, Gustavo, Veronesi, Giovanni, Monique Verschuren, W M, Verstraeten, Roosmarijn, Victora, Cesar G, Viet, Lucie, Viikari-Juntura, Eira, Vineis, Paolo, Vioque, Jesu, Virtanen, Jyrki K, Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vlasoff, Tiina, Vollenweider, Peter, Voutilainen, Sari, Wade, Alisha N, Wagner, Aline, Walton, Janette, Wan Bebakar, Wan Mohamad, Wan Mohamud, Wan Nazaimoon, Wanderley, Rildo S, Wang, Ming-Dong, Wang, Qian, Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S Goya, Wareham, Nichola, Wedderkopp, Niel, Weerasekera, Deepa, Whincup, Peter H, Widhalm, Kurt, Widyahening, Indah S, Wiecek, Andrzej, Wijga, Alet H, Wilks, Rainford J, Willeit, Johann, Willeit, Peter, Williams, Emmanuel A, Wilsgaard, Tom, Wojtyniak, Bogdan, Wong-McClure, Roy A, Wong, Justin Y Y, Wong, Tien Yin, Woo, Jean, Giwercman Wu, Aleksander, Wu, Frederick C, Wu, Shouling, Xu, Haiquan, Yan, Weili, Yang, Xiaoguang, Ye, Xingwang, Yiallouros, Panayiotis K, Yoshihara, Akihiro, Younger-Coleman, Novie O, Yusoff, Ahmad Faudzi, Zainuddin, Ahmad Ali, Zambon, Sabina, Zampelas, Antoni, Zdrojewski, Tomasz, Zeng, Yi, Zhao, Dong, Zhao, Wenhua, Zheng, Wei, Zheng, Yingfeng, Zhu, Dan, Zhussupov, Baurzhan, Zimmermann, Esther, Cisneros, Julio Zuñiga, The State Key Laboratory of Cell Biology [Shanghai, China] (CAS Center for Excellence in Molecular Cell Science), Shanghai Institute of Biochemistry and Cell Biology [Shanghai, China]-University of Chinese Academy of Sciences [Shanghai, China], Imperial College London, University of Kentucky, Middlesex University, Cleveland Clinic, Universidad Peruana Cayetano Heredia (UPCH), Brandeis University, Mulago Hospital [Kampala, Ouganda], Department of Epidemiology and Public Health, Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), World Health Organisation (WHO), Al-Quds University, Discipline of Medicine, University of South Australia [Adelaide], Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán - National Institute of Medical Science and Nutrition Salvador Zubiran [Mexico], Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, Centre for Industrial Management, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Institute of Preventive Medicine, Copenhagen University Hospitals, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Dept. Atherosclerose, University of Iceland [Reykjavik], Institute for Biotechnology and Bioengineering (IBB), Technical University of Lisbon, Medical University of Łódź (MUL), Department of Preventive Medicine and Public Health, Universidad Autónoma de Madrid (UAM), Faculté de Médecine de Tunis, Université de Tunis El Manar (UTM), Sunder Lal Jain Hospital, Ufa Eye Research Institute [Bashkortostan], National Institute of Public Health, Department of Epidemiology, Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke (DifE), Leibniz Association-Leibniz Association, CHU Toulouse [Toulouse], Institute of Social and Preventive Medicine, Lausanne university hospital, Division of Clinical Epidemiology and Aging Research, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Department of Medical Sciences [Turin, Italy] (DMS), Università degli studi di Torino = University of Turin (UNITO), ASU - School for Engineering of Matter, Transport and Energy, Arizona State University [Tempe] (ASU), Universidade do Porto = University of Porto, University of Oxford [Oxford], Cancer & Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center, Consorcio de Investigación Biomédica en Red especializado en Epidemiología y Salud Pública (CIBERESP), Los Centros de Investigación Biomédica en Red (CIBER), 2nd Department of Internal Medicine, Molecular Medicine, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven)-IRC KULAK, Department of Public Health, State University of Ghent, MRC Lifecourse Epidemiology Unit [Southampton, UK], University of Southampton, Réseau International des Instituts Pasteur (RIIP), Institute of Epidemiology [Neuherberg] (EPI), German Research Center for Environmental Health - Helmholtz Center München (GmbH), Sahlgrenska University Hospital [Gothenburg], Institute of Metabolic Science, MRC, Institut National de Nutrition et de Technologie Alimentaire (INNTA), University of Huddersfield, IMIM-Hospital del Mar, Generalitat de Catalunya, Medstar Research Institute, Queen's University [Belfast] (QUB), Medical Research Council, Applied Sciences, National Research Institute on Food and Nutrition, Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Infectious diseases division, Department of internal medicine, Washington University in Saint Louis (WUSTL), Innsbruck Medical University [Austria] (IMU), Department of Epidemiology [Rotterdam], Erasmus University Medical Center [Rotterdam] (Erasmus MC), Laboratoire d'Etude des Mammifères Marins (LEMM), Océanopolis [Brest], Faculté de Médecine Henri Warembourg - Université de Lille, Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark (SDU), Icelandic Heart Association, Heart Preventive Clinic and Research Institute, Centro Investig Quim Aplicada, Coahuila, Mexico, Centro Investigacion en Quimica Aplicada, Coahuila, Mexico, University of Geneva [Switzerland], Department of Civil Engineering [Hamirpur], National Institute of Technology [Hamirpur], Health Services Research Unit, Danish Cancer Society, Institute of Cancer Epidemiology, London School of Hygiene and Tropical Medicine (LSHTM), University College of London [London] (UCL), The Georges Institute for International Health, The University of Sydney, School of Information Technology, Deakin University Waurn Ponds, Faculté de Médecine, Université Djilali Liabès [Sidi-Bel-Abbès], Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), CIBER de Epidemiología y Salud Pública (CIBERESP), VU University Medical Center [Amsterdam], Universiteit Gent = Ghent University [Belgium] (UGENT), Faculty of Agricultural and Food Science, American University of Beirut [Beyrouth] (AUB), Åbo Akademi University [Turku], Department of Public Health Sciences, Karolinska Institutet [Stockholm], Great Lakes Institute for Environmental Research, University of Windsor [Ca], Universität Heidelberg [Heidelberg], Research Center for Prevention and Health, University of Ljubljana, Division of Cancer Epidemiology, University of Crete School of medicine, School of Public Health and Clinical Nutrition, University of Eastern Finland, Institute of Epidemiology and Social Medicine, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Research Institute of Child Nutrition Dortmund, Rheinische Friedrich-Wilhelms-Universität Bonn, Cancer Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge [UK] (CAM), Department of Oncology, University of Tampere Medical School, University of Tampere, Wageningen University and Research [Wageningen] (WUR), Centre for Environmental Health, National Institue of Public Health, School of Public Health, The University of Hong Kong (HKU), Tehran University of Medical Sciences, Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione (INRAN), INRAN, National University of Singapore (NUS), Faculty of Medicine and Life Sciences [Tampere], University of Tampere [Finland], Centre Européen de Réalité Virtuelle (CERV), École Nationale d'Ingénieurs de Brest (ENIB), Uppsala Universitet [Uppsala], Department of Public Health and Community Medicine, University of Gothenburg (GU), Institute of Earthquake Science, CEA, Beijing, CEA, Beijing, University of Porto Medical School, Laboratoire de Chimie Physique D'Orsay (LCPO), Université Paris-Sud - Paris 11 (UP11)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Aging Program, National research council, Padua, Italy, Baker IDI Heart and Diabetes Institute, Institute of Internal Medicine, Russian Academy of Medical Sciences, Department of Nutrition and Dietetics, Harokopio University, Emory University [Atlanta, GA], Départment of Biotechnology, Faculty of Science, University of Oran Es-Senia [Oran] | Université d'Oran Es-Senia [Oran], Institut National de la Santé et de la Recherche Médicale (INSERM), University of Tartu, Department of Community, Université Ain Shams-Faculty of Medicine-Environmental and Occupational Medicine, Pécsi Tudemányegyetem, Department of Community, Environmental and Occupational Medicine, Université Ain Shams, Research Centre in Physical Activity, Health and Leisure, Nutrition and Metabolism Section, International Agency for Research on Cancer, Bushehr University of Medical Sciences, Institute of Epidemiology and Medical Biometry [Ulm, Allemagne], Universität Ulm - Ulm University [Ulm, Allemagne], Università degli studi di Palermo - University of Palermo, MRc Environmental Epidemiology Unit, Department of Cardiology and Department of Clinical Epidemiology, Aarhus University Hospital, Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Department of Epidemiology and Population Studies, Jagiellonian University, Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute – ISPO, Social Robotics Laboratory, University of Freiburg, Freiburg im Breisgau, Department of Ophthalmology, Universitätsklinikum Mannheim, Medizinische Fakultät Mannheim der Universität Heidelberg, University of Bari Aldo Moro (UNIBA), Department of Cardiology, Eastbourne General Hospital, Julius Center for Health Sciences and Primary Care, University Medical Center [Utrecht], Laboratoire d'Innovation pour les Technologies des Energies Nouvelles et les nanomatériaux (LITEN), Institut National de L'Energie Solaire (INES), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), King‘s College London, Public Health Sciences, University of Edinburgh, Movement Disorders and Tourette Centre, Genetica medicala, Victor Babeş University of Medicine and Pharmacy (UMFT), Andrology Unit, United Laboratories of Tartu University Clinics, Tampere University Hospital, Department of Hygiene and Epidemiology, Dept of Epidemiology and Public Health, Department of Epidemiology and Biostatistics, Imperial College London-School of public health, The University of Hong Kong (HKU)-The University of Hong Kong (HKU), Department of Emergency and Cardiovascular Medicine, Sahlgrenska Academy, Institut de Veille Sanitaire (INVS), Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain, parent, Department of Chronic Disease Prevention, National Institute for Health and Welfare [Helsinki], University of São Paulo (USP), Institut de Recherche pour le Développement (IRD [France-Sud]), Institute for plasma research, Institute for Plasma Research, Department of Biosciences and Nutrition, Department of Reproductive Endocrinology, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam UMC - Academic medical center, Central Hospital and Faculty of medicine and biomedical sciences university, University of Yaoundé [Cameroun], Department of Clinical Sciences, Lund University [Lund]-Lund University Diabetes Centre, School of Computing [Leeds], University of Leeds, Copenhagen University Hospital, Neuroépidémiologie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Maastricht University [Maastricht], Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire (IGE-PCV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Applied Food Science, Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, University of Amsterdam, Dept. of Social Medecine, Department of Medical Sciences and Uppsala Clinical Research Center, Uppsala University Hospital, Africa Centre for Health and Population Studies, University of KwaZulu-Natal [Durban, Afrique du Sud] (UKZN)-Medical Research Council of South Africa, Center for Family and Community Medicine, Department of Neurobiology, Care Sciences and Society, Department of Cardiovascular Sciences [Leuven], Cancer Epidemiology Institute, Department of Epidemiology and Health Promotion (MONICA Data Centre), National Public Health Institute, Nutrition et Alimentation des Populations aux Suds (NutriPass), Université Montpellier 1 (UM1)-Institut de Recherche pour le Développement (IRD)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Havard School of Public Health, Dept of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School [Athens], University of Kuopio, Tampere University, University Medical Centre Utrecht, Department of Social Medicine, Amsterdam, Center for Metabolic Bone Diseases, Catholic University of Leuven, Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU), Universidad Miguel Hernández [Elche] (UMH), Institute of Public Health and Clinical Nutrition [Kuopio, Finland], Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg (UNISTRA), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Division of Community Health Sciences, St George's University of London, Medizinische Universität Wien = Medical University of Vienna, Medical University of Silesia (SUM), National Institute for Public Health and the Environment [Bilthoven] (RIVM), University of Innsbruck, National Institute of Hygiene Warsaw, Johns Hopkins University School of Medicine [Baltimore], Food Science and Technology, Beijing Forestry University, College of Automation Engineering, Nanjing University of Aeronautics and Astronautics (CAE-NUAA), NUAA, Chinese Center for Disease Control and Prevention, Department of Applied Mathematics, School of Science, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, Siemens Corporate Research, Siemens AG [Munich], Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), This work was supported by the Wellcome Trust [101506/Z/13/Z]., NCD Risk Factor Collaboration (NCD-RisC). We thank WHO country and regional offices and the World Heart Federation for support in data identification and access., Universidad Autonoma de Madrid (UAM), University of Turin, Universidade do Porto, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Université Lille 2 - Faculté de Médecine, Westfälische Wilhelms-Universität Münster (WWU), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), University of KwaZulu-Natal (UKZN)-Medical Research Council of South Africa, Institut de Recherche pour le Développement (IRD)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), Lund University Diabetes Centre-Lund University [Lund], Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Medical University of Silesia, Katowice, Apollo - University of Cambridge Repository, University of Kentucky (UK), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Lausanne University Hospital, University of Oxford, Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Innsbruck Medical University = Medizinische Universität Innsbruck (IMU), Université de Genève = University of Geneva (UNIGE), Deakin University [Waurn Ponds], Universiteit Gent = Ghent University (UGENT), Universität Heidelberg [Heidelberg] = Heidelberg University, Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Universidade de São Paulo = University of São Paulo (USP), Lund University [Lund], Laboratoire Chrono-environnement (UMR 6249) (LCE), Leopold Franzens Universität Innsbruck - University of Innsbruck, National Institute of Public Health - National Institute of Hygiene [Poland], Yiallouros, Panayiotis K. [0000-0002-8339-9285], Giampaoli, Simona [0000-0002-6679-1488], Moschonis, George [0000-0003-3009-6675], Papandreou, Dimitrios [0000-0002-4923-484X], Stathopoulou, Maria G. [0000-0003-4376-2083], Stergiou, George S. [0000-0002-6132-0038], Trichopoulou, Antonia [0000-0002-7204-6396], Valvi, Damaskini [0000-0003-4633-229X], Chen, Z, Woodward, M, Key, T, and Smith, M
Subjects: systolic blood pressure, Settore MED/09 - Medicina Interna, blood pressure measurement, HEALTH EXAMINATION SURVEYS, Blood Pressure, Hypertension, Population Health, Global Health, Non-communicable Disease, Epidemiology, [SDV]Life Sciences [q-bio], global health, South Asia, purl.org/pe-repo/ocde/ford#3.03.09 [https], kohonnut verenpaine, Medicine and Health Sciences, middle income country, measurement method, skin and connective tissue diseases, VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771, Public, Environmental & Occupational Health, adult, Population health, public health, blood pressure regulation, Public Health, Global Health, Social Medicine and Epidemiology, Non-communicable disease, kansainvälinen vertailu, health survey, aged, female, priority journal, Blood pressure, mean arterial pressure, GLOBAL TRENDS, SODIUM-INTAKE, Life Sciences & Biomedicine, survey design, hypertension, prevalence, Global health, UNITED-STATES, URBAN COMMUNITIES, Article, SECULAR TRENDS, Middle East, Central Asia, male, disease prevalence, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, kansanterveys, blood, SYSTEMATIC ANALYSIS, human, verenpainetauti, non-communicable disease, Science & Technology, Pacific Ocean, high income country, diastolic blood pressure, Pacific Rim, Blood Pressure - Epidemiology - Population, North Africa, major clinical study, HYPERTENSION PREVALENCE, verenpaine, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, ARTERIAL-HYPERTENSION, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, POTASSIUM INTAKE, sense organs, trend analysis, trend study, population research, population health, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, low income country
Abstract: Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean diastolic blood pressure (DBP) and prevalence of raised blood pressure by sex and 10-year age group from 20-29 years to 70-79 years in each study, taking into account complex survey design and survey sample weights, where relevant. We used a linear mixed effect model to quantify the association between (probit-transformed) prevalence of raised blood pressure and age-group-and sex-specific mean blood pressure. We calculated the contributions of change in mean SBP and DBP, and of change in the prevalence-mean association, to the change in prevalence of raised blood pressure. Results: In 2005-16, at the same level of population mean SBP and DBP, men and women in South Asia and in Central Asia, the Middle East and North Africa would have the highest prevalence of raised blood pressure, and men and women in the high-income Asia Pacific and high-income Western regions would have the lowest. In most region-sex-age groups where the prevalence of raised blood pressure declined, one half or more of the decline was due to the decline in mean blood pressure. Where prevalence of raised blood pressure has increased, the change was entirely driven by increasing mean blood pressure, offset partly by the change in the prevalence-mean association. Conclusions: Change in mean blood pressure is the main driver of the worldwide change in the prevalence of raised blood pressure, but change in the high-blood-pressure tail of the distribution has also contributed to the change in prevalence, especially in older age groups., This work was supported by the Wellcome Trust [101506/Z/13/Z].
Published: 2018
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41. Alpha-lipoic Acid Reduces Left Ventricular Mass in Normotensive Type 2 Diabetic Patients With Coronary Artery Disease

Author: Xiang Guang-da, Director of Endocrinol Dept.
Published: 2015

42. Metformin Reduces Left Ventricular Mass in Patients With Ischemic Heart Disease

Author: Xiang Guang-da, Director of Endocrinol Dept.
Published: 2015

43. The Effect of Contrast Agent on Endothelial Function in Healthy Men

Author: Xiang Guang-da, Director of Endocrinol and Metab
Published: 2015

44. The Relation Between Plasma Irisin Level and Endothelial Dysfunction in Type 2 Diabetes

Author: Xiang Guang-da, Director of Endocrinol Dept.
Published: 2015

45. Incidence of Type 1 Diabetes in Children Aged Below 18 Years during 2013-2015 in Northwest Turkey

Author: Tulay Guran, Ilknur Arslanoglu, Ala Üstyol, Sukran Poyrazoglu, Derya Karaman Aksakal, Songül Karadeniz, Nurcan Cebeci, Olcay Evliyaoğlu, Halim Issever, Nihal Memioglu, Ahmet Uçar, Serap Semiz, Firdevs Bas, Didem Bezen, Feyza Darendeliler, Erdal Adal, Gül Yeşiltepe Mutlu, Hasan Önal, Saygin Abali, Abdurrahman Akgun, Serpil Bas, Nese Akcan, Sevil Sarikaya, Gulcan Seymen Karabulut, Ayla Güven, Ömer Tarım, Elif Sagsak, Melek Yildiz, Esra Deniz Papatya Cakir, Havva Nur Peltek, Bahar Ozcabi, Teoman Akcay, Aysegul Yuksel, Şükrü Hatun, Zeynep Atay, Hüseyin Anıl Korkmaz, Mehmet Azizoğlu, Oya Ercan, Pinar Isguven, Aydilek Dağdeviren, Abdullah Bereket, Filiz Tutunculer, Erdal Eren, Semih Bolu, Serap Turan, Tolga Özgen, Filiz Mine Çizmecioğlu, Emine Dilek, Yaşar Cesur, Heves Kırmızıbekmez, Metin Yildiz, Zehra Yavas Abali, Rüveyde Bundak, Cigdem Binay, Fatma Dursun, Acibadem University Dspace, YILDIZ, Mehmet, Tıp Fakültesi, Poyrazoglu, Sukran, Bundak, Ruveyde, Abali, Zehra Yavas, Onal, Hasan, Sarikaya, Sevil, Akgun, Abdurrahman, Bas, Serpil, Abali, Saygin, Bereket, Abdullah, Eren, Erdal, Tarim, Omer, Guven, Ayla, Yildiz, Metin, Aksakal, Derya Karaman, Yuksel, Aysegul, Karabulut, Gulcan Seymen, Hatun, Sukru, Ozgen, Tolga, Cesur, Yasar, Azizoglu, Mehmet, Dilek, Emine, Tutunculer, Filiz, Cakir, Esra Papatya, Ozcabi, Bahar, Evliyaoglu, Olcay, Karadeniz, Songul, Dursun, Fatma, Bolu, Semih, Arslanoglu, Ilknur, Mutlu, Gul Yesiltepe, Kirmizibekmez, Heves, Isguven, Pinar, Ustyol, Ala, Adal, Erdal, Ucar, Ahmet, Cebeci, Nurcan, Bezen, Didem, Binay, Cigdem, Semiz, Serap, Korkmaz, Huseyin Anil, Memioglu, Nihal, Sagsak, Elif, Peltek, Havva Nur, Yildiz, Melek, Akcay, Teoman, Turan, Serap, Guran, Tulay, Atay, Zeynep, Akcan, Nese, Cizmecioglu, Filiz, Ercan, Oya, Dagdeviren, Aydilek, Bas, Firdevs, Issever, Halim, Darendeliler, Feyza, Darendeliler, Feyza Istanbul Univ, Dept Pediat Endocrinol, Istanbul Fac Med, Istanbul, Turkey, Bundak, Ruveyde Univ Kyrenia, Dept Pediat Endocrinol, Fac Med, Kyrenia, North Cyprus, Turkey, Yildiz, Melek Kanuni Sultan Suleyman Training & Res Hosp, Clin Pediat Endocrinol & Metab Dis, Istanbul, Turkey, Atay, Zeynep Marmara Univ, Dept Pediat Endocrinol, Fac Med, Istanbul, Turkey, Abali, Saygin Kartal Training & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey, Tarim, Omer Uludag Univ, Dept Pediat Endocrinol, Fac Med, Bursa, Turkey, Guven, Ayla Amasya Univ, Dept Pediat Endocrinol, Fac Med, Amasya, Turkey, Akcan, Nese Goztepe Training & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey, Cizmecioglu, Filiz Kocaeli Univ, Dept Pediat Endocrinol, Fac Med, Kocaeli, Turkey, Hatun, Sukru Koc Univ, Dept Pediat Endocrinol, Fac Med, Istanbul, Turkey, Cesur, Yasar Bezmialem Vakif Univ, Dept Pediat Endocrinol, Fac Med, Istanbul, Turkey, Tutunculer, Filiz Trakya Univ, Dept Pediat Endocrinol, Fac Med, Edirne, Turkey, Cakir, Esra Papatya Bakirkoy Dr Sadi Konuk Training & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey, Cakir, Esra Papatya Sevket Yilmaz Training & Res Hosp, Clin Pediat Endocrinol, Bursa, Turkey, Dagdeviren, Aydilek Istanbul Univ, Dept Pediat Endocrinol, Cerrahpasa Fac Med, Istanbul, Turkey, Kirmizibekmez, Heves Zeynep Kamil Womens & Childrens Dis Training & Re, Clin Pediat Endocrinol, Istanbul, Turkey, Dursun, Fatma Umraniye Training & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey, Arslanoglu, Ilknur Duzce Univ, Dept Pediat Endocrinol, Fac Med, Istanbul, Turkey, Isguven, Pinar Sakarya Univ, Dept Pediat Endocrinol, Fac Med, Sakarya, Turkey, Ustyol, Ala Haseki Training & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey, Atay, Zeynep Medipol Univ, Dept Pediat Endocrinol, Fac Med, Istanbul, Turkey, Ucar, Ahmet Sisli Etfal Training & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey, Cebeci, Nurcan Derince Training & Res Hosp, Clin Pediat Endocrinol, Kocaeli, Turkey, Bezen, Didem Okmeydani Training & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey, Binay, Cigdem Corlu State Hosp, Clin Pediat Endocrinol, Tekirdag, Turkey, Semiz, Serap Acibadem Univ, Clin Pediat Endocrinol, Fac Med, Istanbul, Turkey, Korkmaz, Huseyin Anil Balikesir Ataturk State Hosp, Clin Pediat Endocrinol, Balikesir, Turkey, Memioglu, Nihal Amer Hosp, Clin Pediat Endocrinol, Istanbul, Turkey, Sagsak, Elif Gaziosmanpasa Taksim Training & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey, Peltek, Havva Nur Edirne Sultan 1 Murat State Hosp, Clin Pediat Endocrinol, Edirne, Turkey, Akcay, Teoman Med Pk Gaziosmanpasa Hosp, Clin Pediat Endocrinol, Istanbul, Turkey, Akcan, Nese Univ Near East, Dept Pediat Endocrinol, Fac Med, Nicosia, North Cyprus, Turkey, Issever, Halim Istanbul Univ, Dept Publ Hlth, Istanbul Fac Med, Istanbul, Turkey, ABALI, SAYGIN -- 0000-0001-6552-2801, Turan, Serap -- 0000-0002-5172-5402, Hatun, Sukru -- 0000-0003-1633-9570, yesiltepe mutlu, gul -- 0000-0003-3919-7763, and [Poyrazoglu, Sukran -- Bundak, Ruveyde -- Abali, Zehra Yavas -- Bas, Firdevs -- Darendeliler, Feyza] Istanbul Univ, Dept Pediat Endocrinol, Istanbul Fac Med, Istanbul, Turkey -- [Bundak, Ruveyde] Univ Kyrenia, Dept Pediat Endocrinol, Fac Med, Kyrenia, North Cyprus, Turkey -- [Onal, Hasan -- Sarikaya, Sevil -- Akgun, Abdurrahman -- Yildiz, Melek] Kanuni Sultan Suleyman Training & Res Hosp, Clin Pediat Endocrinol & Metab Dis, Istanbul, Turkey -- [Bas, Serpil -- Abali, Saygin -- Bereket, Abdullah -- Turan, Serap -- Guran, Tulay -- Atay, Zeynep] Marmara Univ, Dept Pediat Endocrinol, Fac Med, Istanbul, Turkey -- [Abali, Saygin] Kartal Training & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey -- [Eren, Erdal -- Tarim, Omer] Uludag Univ, Dept Pediat Endocrinol, Fac Med, Bursa, Turkey -- [Guven, Ayla] Amasya Univ, Dept Pediat Endocrinol, Fac Med, Amasya, Turkey -- [Guven, Ayla -- Yildiz, Metin -- Aksakal, Derya Karaman -- Akcan, Nese] Goztepe Training & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey -- [Yuksel, Aysegul -- Karabulut, Gulcan Seymen -- Hatun, Sukru -- Mutlu, Gul Yesiltepe -- Cizmecioglu, Filiz] Kocaeli Univ, Dept Pediat Endocrinol, Fac Med, Kocaeli, Turkey -- [Hatun, Sukru] Koc Univ, Dept Pediat Endocrinol, Fac Med, Istanbul, Turkey -- [Ozgen, Tolga -- Cesur, Yasar] Bezmialem Vakif Univ, Dept Pediat Endocrinol, Fac Med, Istanbul, Turkey -- [Azizoglu, Mehmet -- Dilek, Emine -- Tutunculer, Filiz] Trakya Univ, Dept Pediat Endocrinol, Fac Med, Edirne, Turkey -- [Cakir, Esra Papatya] Bakirkoy Dr Sadi Konuk Training & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey -- [Cakir, Esra Papatya] Sevket Yilmaz Training & Res Hosp, Clin Pediat Endocrinol, Bursa, Turkey -- [Ozcabi, Bahar -- Evliyaoglu, Olcay -- Karadeniz, Songul -- Ercan, Oya -- Dagdeviren, Aydilek] Istanbul Univ, Dept Pediat Endocrinol, Cerrahpasa Fac Med, Istanbul, Turkey -- [Ozcabi, Bahar -- Mutlu, Gul Yesiltepe -- Kirmizibekmez, Heves] Zeynep Kamil Womens & Childrens Dis Training & Re, Clin Pediat Endocrinol, Istanbul, Turkey -- [Dursun, Fatma] Umraniye Training & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey -- [Bolu, Semih -- Arslanoglu, Ilknur] Duzce Univ, Dept Pediat Endocrinol, Fac Med, Istanbul, Turkey -- [Isguven, Pinar] Sakarya Univ, Dept Pediat Endocrinol, Fac Med, Sakarya, Turkey -- [Ustyol, Ala] Haseki Training & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey -- [Adal, Erdal -- Atay, Zeynep] Medipol Univ, Dept Pediat Endocrinol, Fac Med, Istanbul, Turkey -- [Ucar, Ahmet] Sisli Etfal Training & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey -- [Cebeci, Nurcan] Derince Training & Res Hosp, Clin Pediat Endocrinol, Kocaeli, Turkey -- [Bezen, Didem] Okmeydani Training & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey -- [Binay, Cigdem] Corlu State Hosp, Clin Pediat Endocrinol, Tekirdag, Turkey -- [Semiz, Serap] Acibadem Univ, Clin Pediat Endocrinol, Fac Med, Istanbul, Turkey -- [Korkmaz, Huseyin Anil] Balikesir Ataturk State Hosp, Clin Pediat Endocrinol, Balikesir, Turkey -- [Memioglu, Nihal] Amer Hosp, Clin Pediat Endocrinol, Istanbul, Turkey -- [Sagsak, Elif] Gaziosmanpasa Taksim Training & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey -- [Peltek, Havva Nur] Edirne Sultan 1 Murat State Hosp, Clin Pediat Endocrinol, Edirne, Turkey -- [Akcay, Teoman] Med Pk Gaziosmanpasa Hosp, Clin Pediat Endocrinol, Istanbul, Turkey -- [Akcan, Nese] Univ Near East, Dept Pediat Endocrinol, Fac Med, Nicosia, North Cyprus, Turkey -- [Issever, Halim] Istanbul Univ, Dept Publ Hlth, Istanbul Fac Med, Istanbul, Turkey
Subjects: Male, Turkey, Epidemiology, Endocrinology, Diabetes and Metabolism, Cohort Studies, MELLITUS, 0302 clinical medicine, Endocrinology, Rapidly Rising Incidence, Diagnosis, Prevalence, EPIDEMIOLOGY, Registries, 030212 general & internal medicine, Child, Geography, Incidence, Incidence (epidemiology), PREVALENCE, TIME, Seasonal-Variatin, Child, Preschool, Original Article, Female, Seasons, Male predominance, Cohort study, Adolescent, SEASONAL-VARIATION, Type 1 diabetes mellitus, 030209 endocrinology & metabolism, RAPIDLY RISING INCIDENCE, DIAGNOSIS, NATIONWIDE INCIDENCE, World health, Time, Nationwide Incidence, 03 medical and health sciences, Diabetes mellitus, POYRAZOĞLU Ş., BUNDAK R., Yavaş A., ÖNAL H., SARıKAYA S., AKGÜN A., BAŞ S., ABALı S., BEREKET A., EREN E., et al., -Incidence of Type 1 Diabetes in Children Aged Below 18 Years during 2013-2015 in Northwest Turkey-, Journal of clinical research in pediatric endocrinology, cilt.10, ss.336-342, 2018, medicine, Humans, childhood, Onset, Type 1 diabetes, Standard Population, business.industry, Mellitus, Infant, Newborn, Infant, Type 1 Diabetes Mellitus, medicine.disease, TRENDS, Childhood, Confidence interval, Diabetes Mellitus, Type 1, ONSET, Pediatrics, Perinatology and Child Health, incidence, Trends, business, Demography
Abstract: ABALI, SAYGIN/0000-0001-6552-2801; Turan, Serap/0000-0002-5172-5402; Hatun, Sukru/0000-0003-1633-9570; Akgun, Abdurrahman/0000-0002-2917-2469; yesiltepe mutlu, gul/0000-0003-3919-7763; Ozgen, Ilker Tolga/0000-0001-6592-9652 WOS: 000451667000006 PubMed: 29789274 Objective: To assess the incidence of type I diabetes mellitus (T1DM) in children under 18 years of age in the northwest region of Turkey during 2013-2015. Methods: All newly diagnosed T1DM cases were recorded prospectively during 2013-2015. Total, as well as gender and age group specific (0-4, 5-9. 10-14 and 15-17 age) mean incidences per 100,000 per year were calculated. Results: There were 1,773 patients diagnosed during 2013-2015 (588 cases in 2013, 592 cases in 2014, 593 cases in 2015). Of these, 862 (48.6 %) were girls and 911 (51.4%)were boys. The mean age at diagnosis was 9.2 +/- 4.2 years and it was not significantly different between girls (9.0 +/- 4.1 years) and boys (9.4 +/- 4.4 years) (p = 0.052). The crude mean incidence was 8.99/100.000 confidence interval (CI) (95% CI: 8.58-9.42). Although mean incidence was similar between boys [8.98/100.000 (CI: 8.40 to 9.58)] and girls [9.01/100.000 (CI: 8.42 to 9.63)], there was male predominance in all groups except for 5-9 year age group. The standardized mean incidence was 9.02/100.000 according to the World Health Organization standard population. The mean incidence for the 0-4, 5-9, 10-14 and 15-17 age groups was 6.13, 11.68, 11.7 and 5.04/1 00.000 respectively. The incidence of T1DM was similar over the course of three years (p = 0.95). A significant increase in the proportion of cases diagnosed was observed in the autumn-winter seasons. Conclusion: The northwest region of Turkey experienced an intermediate incidence of T1DM over the period of the study.
Published: 2018

46. Homozygous loss-of-function mutations in SLC26A7 cause goitrous congenital hypothyroidism

Author: Cangul, Hakan, Liao, Xiao-Hui, Schoenmakers, Erik, Kero, Jukka, Barone, Sharon, Srichomkwun, Panudda, Iwayama, Hideyuki, Serra, Eva G, Saglam, Halil, Eren, Erdal, Tarim, Omer, Nicholas, Adeline K, Zvetkova, Ilona, Anderson, Carl A, Frankl, Fiona E Karet, Boelaert, Kristien, Ojaniemi, Marja, Jääskeläinen, Jarmo, Patyra, Konrad, Löf, Christoffer, Williams, E Dillwyn, UK10K Consortium, Soleimani, Manoocher, Barrett, Timothy, Maher, Eamonn R, Chatterjee, V Krishna, Refetoff, Samuel, Schoenmakers, Nadia, Cangul, Hakan Istanbul Medipol Univ, Dept Med Genet, Int Sch Med, Istanbul, Turkey, Liao, Xiao-Hui, Srichomkwun, Panudda, Iwayama, Hideyuki, Refetoff, Samuel Univ Chicago, Dept Med, 5841 S Maryland Ave, Chicago, IL 60637 USA, Schoenmakers, Erik, Nicholas, Adeline K., Zvetkova, Ilona, Chatterjee, V. Krishna, Schoenmakers, Nadia Univ Cambridge, Metabol Res Labs, Wellcome Trust Med Res Council, Inst Metab Sci,Addenbrookes Hosp, Level 4,Box 289,Hills Rd, Cambridge CB2 0QQ, England, Kero, Jukka, Patyra, Konrad, Lof, Christoffer Univ Turku, Res Ctr Integrat Physiol & Pharmacol, Inst Biomed, Turku, Finland, Kero, Jukka Turku Univ Hosp, Dept Paediat, Turku, Finland, Barone, Sharon, Soleimani, Manoocher Univ Cincinnati, Cincinnati, OH USA, Soleimani, Manoocher Vet Adm Hosp, Cincinnati, OH USA, Serra, Eva G., Anderson, Carl A. Wellcome Trust Sanger Inst, Dept Human Genet, Cambridge, England, Saglam, Halil, Eren, Erdal, Tarim, Omer Uludag Univ, Sch Med, Dept Paediat Endocrinol, Bursa, Turkey, Frankl, Fiona E. Karet Univ Cambridge, Dept Med Genet, Cambridge, England, Frankl, Fiona E. Karet Univ Cambridge, Div Renal Med, Cambridge, England, Boelaert, Kristien Univ Birmingham, Inst Metab & Syst Res, Birmingham, W Midlands, England, Boelaert, Kristien Birmingham Hlth Partners, Ctr Endocrinol Diabet & Metab, Birmingham, W Midlands, England, Ojaniemi, Marja Univ Oulu, PEDEGO Res Ctr, Oulu, Finland, Ojaniemi, Marja Univ Oulu, MRC Oulu, Oulu, Finland, Ojaniemi, Marja Oulu Univ Hosp, Dept Children & Adolescents, Oulu, Finland, Jaaskelainen, Jarmo Univ Eastern Finland, Dept Pediat, Kuopio, Finland, Jaaskelainen, Jarmo Kuopio Univ Hosp, Kuopio, Finland, Williams, E. Dillwyn Univ Cambridge, Thyroid Carcinogenesis Grp, Strangeways Res Lab, Cambridge, England, Consortium, Ukk Univ Birmingham, Consortium Detailed Supplemental Acknowledgments, Birmingham, W Midlands, England, Barrett, Timothy Univ Birmingham, Inst Canc & Genom Sci, Coll Med & Dent Sci, Birmingham, W Midlands, England, Barrett, Timothy Birmingham Childrens Hosp, Dept Endocrinol, Birmingham, W Midlands, England, Maher, Eamonn R. Univ Cambridge, Dept Med Genet, Cambridge, England, Maher, Eamonn R. NIHR Cambridge Biomed Res Ctr, Cambridge, England, Refetoff, Samuel Univ Chicago, Dept Pediat, Chicago, IL 60637 USA, Refetoff, Samuel Univ Chicago, Comm Genet, Chicago, IL USA, Barrett, Timothy -- 0000-0002-6873-0750, MAHER, EAMONN R -- 0000-0002-6226-6918, Schoenmakers, Nadia -- 0000-0002-0847-2884, Eren, Erdal -- 0000-0002-1684-1053, Kelly, Kirsten -- 0000-0003-4234-543X, kero, jukka -- 0000-0001-8767-7222, Anderson, Carl -- 0000-0003-1719-7009, Schoenmakers, Erik [0000-0003-0674-8282], Karet, Fiona [0000-0002-2457-2869], Maher, Eamonn [0000-0002-6226-6918], Chatterjee, Krishna [0000-0002-2654-8854], Schoenmakers, Nadia [0000-0002-0847-2884], and Apollo - University of Cambridge Repository
Subjects: Adult, Male, endocrine system, endocrine system diseases, DNA Mutational Analysis, Thyroid Gland, Antiporters, Vestibular Aqueduct, Monogenic diseases, Mice, Endocrinology, Exome Sequencing, Genetics, Congenital Hypothyroidism, otorhinolaryngologic diseases, Animals, Humans, Molecular genetics, Hearing Loss, Child, Mice, Knockout, Goiter, Homozygote, Middle Aged, Thyroid disease, Pedigree, HEK293 Cells, Codon, Nonsense, Sulfate Transporters, FOS: Biological sciences, Child, Preschool, Female, Aqueduct EVA
Abstract: WOS: 000447709700003 PubMed ID: 30333321 Defects in genes mediating thyroid hormone biosynthesis result in dyshormonogenic congenital hypothyroidism (CH). Here, we report homozygous truncating mutations in SLC26A7 in 6 unrelated families with goitrous CH and show that goitrous hypothyroidism also occurs in Slc26a7-null mice. In both species, the gene is expressed predominantly in the thyroid gland, and loss of function is associated with impaired availability of iodine for thyroid hormone synthesis, partially corrected in mice by iodine supplementation. SLC26A7 is a member of the same transporter family as SLC26A4 (pendrin), an anion exchanger with affinity for iodide and chloride (among others), whose gene mutations cause congenital deafness and dyshormonogenic goiter. However, in contrast to pendrin, SLC26A7 does not mediate cellular iodide efflux and hearing in affected individuals is normal. We delineate a hitherto unrecognized role for SLC26A7 in thyroid hormone biosynthesis, for which the mechanism remains unclear. Wellcome Trust; NIDDK NIH HHS [R37 DK015070, R01 DK015070]; Medical Research Council [MC_UU_12012/5, G0600717, G0502115]
Published: 2018

47. Response to growth hormone treatment in very young patients with growth hormone deficiencies and mini-puberty

Author: Zeynep Şıklar, Zehra Aycan, Filiz Mine Çizmecioğlu Jones, Enver Simsek, Meltem Tayfun, Semra Çetinkaya, Mehmet Nuri Ozbek, Eda Mengen, Erdal Adal, Metin Yildiz, Merih Berberoğlu, Iffet Bircan, Oya Ercan, Sukran Poyrazoglu, Firdevs Bas, Şenay Savaş Erdeve, Semih Bolu, Abdullah Bereket, Muammer Buyukinan, Ayhan Abaci, Feyza Darendeliler, Saygin Abali, Şükran Darcan, Esra D. Papatya, Çukurova Üniversitesi, Cetinkaya, Semra, Erdeve, Senay Savas Hlth Sci Univ, Hlth Implementat & Res Ctr, Dr Sami Ulus Obstet & Gynecol, Dept Pediat Endocrinol,Childrens Hlth & Dis, Ankara, Turkey, Poyrazoglu, Sukran, Bas, Firdevs, Darendeliler, Feyza Istanbul Univ, Inst Child Hlth, Fac Med, Dept Pediat Endocrinol, Istanbul, Turkey, Ercan, Oya Istanbul Univ, Cerrahpasa Med Fac, Dept Pediat Endocrinol, Istanbul, Turkey, Yildiz, Metin Goztepe Training & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey, Adal, Erdal Istanbul Medipol Univ, Dept Pediat Endocrinol, Istanbul, Turkey, Bereket, Abdullah, Abali, Saygin Marmara Univ, Fac Med, Dept Pediat Endocrinol, Istanbul, Turkey, Aycan, Zehra Childrens Hlth & Dis Training & Res Hosp, Dr Sami Ulus Obstet & Gynecol, Dept Pediat Endocrinol, Ankara, Turkey, Aycan, Zehra Yildirim Beyazit Univ, Fac Med, Ankara, Turkey, Berberoglu, Merih, Siklar, Zeynep Ankara Univ, Sch Med, Dept Pediat Endocrinol, Ankara, Turkey, Tayfun, Meltem Ankara Childrens Hematol & Oncol Res & Training H, Dept Pediat Endocrinol, Ankara, Turkey, Darcan, Sukran Ege Univ, Fac Med, Dept Pediat Endocrinol, Izmir, Turkey, Mengen, Eda Cukurova Univ, Fac Med, Dept Pediat Endocrinol, Adana, Turkey, Bircan, Iffet Akdeniz Univ, Fac Med, Dept Pediat Endocrinol, Antalya, Turkey, Jones, Filiz Mine Cizmecioglu Kocaeli Univ, Fac Med, Dept Pediat Endocrinol, Kocaeli, Turkey, Simsek, Enver Osmangazi Univ, Fac Med, Dept Pediat Endocrinol, Eskisehir, Turkey, Papatya, Esra Deniz Bakirkoy Dr Sadi Konuk Educ & Res Hosp, Clin Pediat Endocrinol, Istanbul, Turkey, Ozbek, Mehmet Nuri Hlth Sci Univ, Gazi Yasargil Educ & Training Hosp, Clin Pediat Endocrinol, Diyarbakir, Turkey, Bolu, Semih Duzce Univ, Fac Med, Dept Pediat Endocrinol, Konuralp, Duzce, Turkey, Abaci, Ayhan Dokuz Eylul Univ, Fac Med, Dept Pediat Endocrinol, Izmir, Turkey, Buyukinan, Muammer Konya Educ & Res Hosp, Clin Pediat Endocrinol, Konya, Turkey, ABALI, SAYGIN -- 0000-0001-6552-2801, and Abaci, Ayhan -- 0000-0002-1812-0321
Subjects: Male, growth hormone deficiency, medicine.medical_specialty, Turkey, Hormone Replacement Therapy, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, growth response, Weight Gain, Growth hormone, Hypopituitarism, Growth hormone deficiency, Cohort Studies, 03 medical and health sciences, Child Development, 0302 clinical medicine, Endocrinology, Isolated GH Deficiency, 030225 pediatrics, Internal medicine, Humans, Medicine, infancy, Dwarfism, Pituitary, Retrospective Studies, Puberty, Delayed, Sex Steroid Hormones, Human Growth Hormone, business.industry, Hypogonadism, Age Factors, Infant, growth hormone treatment, medicine.disease, Mini Puberty, Body Height, Hypoglycemia, Recombinant Proteins, mini-puberty, Growth hormone treatment, Child, Preschool, Pediatrics, Perinatology and Child Health, Cohort, IGHD, Female, medicine.symptom, business, Weight gain
Abstract: PubMedID: 29353264 The aim of the study was to assess the response to growth hormone (GH) treatment in very young patients with GH deficiency (GHD) through a national, multi-center study. Possible factors affecting growth response were assessed (especially mini-puberty). Medical reports of GHD patients in whom treatment was initiated between 0 and 3 years of age were retrospectively evaluated. The cohort numbered 67. The diagnosis age was 12.4±8.6 months, peak GH stimulation test response (at diagnosis) as 1.0±1.4 ng/mL. The first and second years length gain was 15.0±4.3 and 10.4±3.4 cm. Weight gain had the largest effect on first year growth response; whereas weight gain and GH dose were both important factors affecting second year growth response. In the multiple pituitary hormone deficiency (MPHD) group (n=50), first year GH response was significantly greater than in the isolated GH deficiency (IGHD) group (n=17) (p=0.030). In addition first year growth response of infants starting GH between 0 and 12 months of age (n=24) was significantly greater than those who started treatment between 12 and 36 months of age (n=43) (p
Published: 2018

48. IGFBP-3 Interacts with the Vitamin D Receptor in Insulin Signaling Associated with Obesity in Visceral Adipose Tissue

Author: Francisco J. Tinahones, María Fernanda Lara, Inmaculada Moreno-Santos, Manuel Macias-Gonzalez, José Carlos Fernández-García, Daniel Castellano-Castillo, [Moreno-Santos, Inmaculada] Univ Malaga, Complejo Hosp Malaga Virgen de la Victoria, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Malaga 29010, Spain, [Castellano-Castillo, Daniel] Univ Malaga, Complejo Hosp Malaga Virgen de la Victoria, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Malaga 29010, Spain, [Carlos Fernandez-Garcia, Jose] Univ Malaga, Complejo Hosp Malaga Virgen de la Victoria, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Malaga 29010, Spain, [Jose Tinahones, Francisco] Univ Malaga, Complejo Hosp Malaga Virgen de la Victoria, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Malaga 29010, Spain, [Macias-Gonzalez, Manuel] Univ Malaga, Complejo Hosp Malaga Virgen de la Victoria, Inst Invest Biomed Malaga IBIMA, Unidad Gest Clin Endocrinol & Nutr, Malaga 29010, Spain, [Moreno-Santos, Inmaculada] CIBER Pathophysiol Obes & Nutr CB06 03, Malaga 29010, Spain, [Castellano-Castillo, Daniel] CIBER Pathophysiol Obes & Nutr CB06 03, Malaga 29010, Spain, [Carlos Fernandez-Garcia, Jose] CIBER Pathophysiol Obes & Nutr CB06 03, Malaga 29010, Spain, [Jose Tinahones, Francisco] CIBER Pathophysiol Obes & Nutr CB06 03, Malaga 29010, Spain, [Macias-Gonzalez, Manuel] CIBER Pathophysiol Obes & Nutr CB06 03, Malaga 29010, Spain, [Fernanda Lara, Maria] Univ Malaga, Complejo Hosp Malaga Virgen de la Victoria, Dept Urol, Malaga 29010, Spain, 'Centros de Investigacion En Red' (CIBER) of the 'Instituto de Salud Carlos III' (ISCIII), ISCIII, European Regional Development Fund (FEDER), Education Ministry, Madrid, Spain, Servicio Andaluz de Salud (SAS), and Nicolas Monardes Programme from the 'Servicio Andaluz de Salud, Junta de Andalucia', Spain
Subjects: 0301 basic medicine, Male, medicine.medical_treatment, Adipose tissue, vitamin D, Growth, Calcitriol receptor, lcsh:Chemistry, chemistry.chemical_compound, Adipocyte, insulin resistance, IGFBP, Gene-expression, Receptor, lcsh:QH301-705.5, Spectroscopy, Adipogenesis, biology, morbid obesity and adipose, General Medicine, Middle Aged, Computer Science Applications, Adipose Tissue, Regression Analysis, Female, Protein Binding, Signal Transduction, Adult, medicine.medical_specialty, Glucose-homeostasis, Intra-Abdominal Fat, Real-Time Polymerase Chain Reaction, Catalysis, Article, Inorganic Chemistry, 03 medical and health sciences, Insulin resistance, Internal medicine, medicine, Retinoic acid, Humans, Obesity, RNA, Messenger, Physical and Theoretical Chemistry, Molecular Biology, VDR, Inflammation, Adipocyte differentiation, Insulin, Organic Chemistry, medicine.disease, Insulin-Like Growth Factor Binding Protein 1, Insulin receptor, Insulin-Like Growth Factor Binding Protein 2, 030104 developmental biology, Endocrinology, Insulin-Like Growth Factor Binding Protein 3, chemistry, lcsh:Biology (General), lcsh:QD1-999, Insulin-Like Growth Factor Binding Protein 4, Nuclear receptor, biology.protein, Igf-i, Receptors, Calcitriol, Inverse-agonist
Abstract: Adipose tissue has traditionally only been considered as an energy storage organ. Nevertheless, the importance of this tissue in systemic physiology and, especially, in systemic inflammation has been highlighted in recent years. Adipose tissue expresses proteins related to vitamin D (VD) metabolism, and it has been proposed that it can act as a VD storage tissue. The active form of VD, 1,25-dihydroxyvitamin D3 (1,25(OH)(2)D-3), is able to modify adipocyte and adipose tissue physiology via the VD receptor (VDR), decreasing the expression of pro-inflammatory cytokines in adipose tissue. Moreover, VD deficiency and VDR has been reported to be associated with obesity and diabetes. However, the results of the different studies are not conclusive. Insulin growth binding proteins (IGFBPs) have been identified in adipose tissue, but their roles are poorly understood. Therefore, the objective of this study was to analyze the plasma levels of VD and the gene expression of VDR in the adipose tissue of subjects with morbid obesity (MO) and with different degrees of insulin resistance (IR), as well as the functionality of direct interaction between IGFBP-3 and VDR, which could explain its inhibitory role in adipogenesis. Our results show a novel role of the VD system in the regulation and activation of IGFBP-3 in visceral adipose tissue (VAT) of patients with MO, as a new and alternative mechanism proposed in the insulin signaling associated with obesity.
Published: 2017

49. Different response to hypoxia of adipose-derived multipotent cells from obese subjects with and without metabolic syndrome

Author: Said Lhamyani, Leticia Coín-Aragüez, Isabel Moreno-Indias, Wilfredo Oliva-Olivera, Joan Vendrell, Rajaa El Bekay, Sonia Fernández-Veledo, Antonio Camargo, Juan Alcaide Torres, Francisco J. Tinahones, [Oliva-Olivera, Wilfredo] Univ Malaga UMA, Hosp Malaga Virgen de la Victoria, Dept Clin Endocrinol & Nutr, Inst Biomed Res Malaga IBIMA, Malaga, Spain, [Moreno-Indias, Isabel] Univ Malaga UMA, Hosp Malaga Virgen de la Victoria, Dept Clin Endocrinol & Nutr, Inst Biomed Res Malaga IBIMA, Malaga, Spain, [Coin-Araguez, Leticia] Univ Malaga UMA, Hosp Malaga Virgen de la Victoria, Dept Clin Endocrinol & Nutr, Inst Biomed Res Malaga IBIMA, Malaga, Spain, [Alcaide Torres, Juan] Univ Malaga UMA, Hosp Malaga Virgen de la Victoria, Dept Clin Endocrinol & Nutr, Inst Biomed Res Malaga IBIMA, Malaga, Spain, [El Bekay, Rajaa] Univ Malaga UMA, Hosp Malaga Virgen de la Victoria, Dept Clin Endocrinol & Nutr, Inst Biomed Res Malaga IBIMA, Malaga, Spain, [Jose Tinahones, Francisco] Univ Malaga UMA, Hosp Malaga Virgen de la Victoria, Dept Clin Endocrinol & Nutr, Inst Biomed Res Malaga IBIMA, Malaga, Spain, [Oliva-Olivera, Wilfredo] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nut, Madrid, Spain, [Moreno-Indias, Isabel] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nut, Madrid, Spain, [Coin-Araguez, Leticia] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nut, Madrid, Spain, [Alcaide Torres, Juan] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nut, Madrid, Spain, [Camargo, Antonio] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nut, Madrid, Spain, [El Bekay, Rajaa] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nut, Madrid, Spain, [Jose Tinahones, Francisco] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nut, Madrid, Spain, [Lhamyani, Said] Univ Malaga UMA, Res Lab, Sci Sch, Malaga, Spain, [Fernandez-Veledo, Sonia] Univ Rovirai Virgili, Hosp Univ Tarragona Joan 23, Inst Invest Sanitaria Pere Virgili, Tarragona, Spain, [Vendrell, Joan] Univ Rovirai Virgili, Hosp Univ Tarragona Joan 23, Inst Invest Sanitaria Pere Virgili, Tarragona, Spain, [Fernandez-Veledo, Sonia] Inst Salud Carlos III, CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid, Spain, [Vendrell, Joan] Inst Salud Carlos III, CIBER Diabet & Enfermedades Metab Asociadas CIBER, Madrid, Spain, [Camargo, Antonio] Univ Cordoba, Reina Sofia Univ Hosp, Lipids & Atherosclerosis Unit, IMIBIC, Cordoba, Spain, European Union through the European Regional Development Fund (FEDER), Ministry of Economy and Competitiveness, Institute of Health Carlos III, Ministry of Economy and Knowledge, and Fondo de Investigacion Sanitaria (FIS) - European Regional Development Fund (ERDF)
Subjects: 0301 basic medicine, Vascular Endothelial Growth Factor A, Pulmonology, Angiogenesis, Physiology, Improve postnatal neovascularization, lcsh:Medicine, Adipose tissue, Gene Expression, Cell Count, Pathology and Laboratory Medicine, Progenitor cells, Tissue angiogenesis, chemistry.chemical_compound, Endocrinology, Cell Movement, Immune Physiology, Endothelial-cells, Medicine and Health Sciences, lcsh:Science, Hypoxia, Immune Response, Cells, Cultured, Metabolic Syndrome, Innate Immune System, Multidisciplinary, Anthropometry, Hepatocyte Growth Factor, Vascular endothelial growth factor, Endothelial stem cell, Vascular endothelial growth factor A, Physiological Parameters, Adipose Tissue, Cytokines, medicine.symptom, Anatomy, Inflammation Mediators, Mesenchymal stem-cells, Oxidation-Reduction, Research Article, Adult, medicine.medical_specialty, Immunology, Neovascularization, Physiologic, Inflammation, Biology, Models, Biological, Immunophenotyping, Receptor, Platelet-Derived Growth Factor beta, 03 medical and health sciences, Insulin resistance, Signs and Symptoms, Diagnostic Medicine, Internal medicine, Growth Factors, Medical Hypoxia, medicine, Genetics, Humans, Macrophage infiltration, Obesity, Stromal cells, Endocrine Physiology, Multipotent Stem Cells, lcsh:R, Body Weight, Biology and Life Sciences, NADPH Oxidases, Insulin-resistance, Molecular Development, medicine.disease, Chemokine CXCL12, Oxygen, 030104 developmental biology, Biological Tissue, chemistry, Gene Expression Regulation, Oxidative stress, Metabolic Disorders, Immune System, Culture Media, Conditioned, lcsh:Q, Metabolic syndrome, Developmental Biology
Abstract: Background/Objectives Multiple studies suggest that hypoxia, together with inflammation, could be one of the phenomena involved in the onset and progression of obesity-related insulin resistance. In addition, dysfunction of adipose tissue in obese subjects with metabolic syndrome is associated with decreased angiogenesis. However, some subjects with a high body mass index do not develop metabolic abnormalities associated with obesity. The aim of the current study was to examine the neovascular properties of visceral adipose tissue-derived multipotent mesenchymal cells subjected to hypoxia (hypox-visASCs) from normal-weight subjects (Nw) and obese patients with metabolic syndrome (MS) and without metabolic syndrome (NonMS). Methods This was a 2-year study to enroll subjects who underwent bariatric surgery or cholecystectomy. Eight patients who underwent either bariatric surgery or cholecystectomy (27 patients) participated in the study. Visceral adipose tissue samples from Nw, MS and NonMS subjects were processed by enzymatic digestion. VisASCs cultured under hypoxic conditions were characterized by tubule formation assay, ELISA, flow cytometry, migration rate, and qRT-PCR, and the effects of visASCs-conditioned medium on survival and endothelial cell tubule formation were evaluated. Results Hypox-visASCs from NonMS subjects showed a greater capacity for tubule formation than hypox-visASCs from Nw and MS subjects. The lower percentage of CD140b+/CD44+ and CD140b+/CD184+ cells observed in hypox-visASCs from NonMS subjects compared to MS subjects was accompanied not only by a lower migration rate from the chemotactic effects of stromal cell derived factor 1α, but also by lower levels of NOX5 mRNA expression. While the levels of monocyte chemoattractant protein 1 mRNA expressed by hypox-visASCs correlated positively with the body mass index and waist circumference of the subjects, the concentration of vascular endothelial growth factor present in hypox-visASC-conditioned culture medium decreased significantly with increasing plasma glucose. The survival rate and tubules formed by endothelial cells cultured in hypox-visASC-conditioned medium decreased significantly with increasing homeostasis model assessment to quantify insulin resistance. Conclusions Our results suggest that hypox-visASCs from NonMS subjects could promote healthy adipose tissue expansion, while hypox-visASCs from MS subjects appear to contribute to the decreased angiogenic potential and increased inflammation underlying adipose tissue dysfunction in obesity. Our results emphasize the importance of taking into account not only the BMI but also the metabolic profile of the subjects during the implementation of ASCs-based therapy to promote neovascularization.
Published: 2017

50. Comparison of the Effects of Goat Dairy and Cow Dairy Based Breakfasts on Satiety, Appetite Hormones, and Metabolic Profile

Author: Fuensanta Lima-Rubio, Laura Peláez, Francisco-Javier Bermúdez-Silva, Gemma Rojo-Martínez, Eva García-Escobar, Federico Soriguer, Maria-Soledad Ruiz de Adana, Angel-María Caracuel, Elehazara Rubio-Martín, Gabriel Olveira, [Rubio-Martin, Elehazara] Univ Malaga, Hosp Univ Reg Malaga, Inst Invest Biomed Malaga IBIMA, UGC Endocrinol & Nutr, Malaga 29009, Spain, [Garcia-Escobar, Eva] Univ Malaga, Hosp Univ Reg Malaga, Inst Invest Biomed Malaga IBIMA, UGC Endocrinol & Nutr, Malaga 29009, Spain, [Ruiz de Adana, Maria-Soledad] Univ Malaga, Hosp Univ Reg Malaga, Inst Invest Biomed Malaga IBIMA, UGC Endocrinol & Nutr, Malaga 29009, Spain, [Lima-Rubio, Fuensanta] Univ Malaga, Hosp Univ Reg Malaga, Inst Invest Biomed Malaga IBIMA, UGC Endocrinol & Nutr, Malaga 29009, Spain, [Pelaez, Laura] Univ Malaga, Hosp Univ Reg Malaga, Inst Invest Biomed Malaga IBIMA, UGC Endocrinol & Nutr, Malaga 29009, Spain, [Caracuel, Angel-Maria] Univ Malaga, Hosp Univ Reg Malaga, Inst Invest Biomed Malaga IBIMA, UGC Endocrinol & Nutr, Malaga 29009, Spain, [Bermudez-Silva, Francisco-Javier] Univ Malaga, Hosp Univ Reg Malaga, Inst Invest Biomed Malaga IBIMA, UGC Endocrinol & Nutr, Malaga 29009, Spain, [Soriguer, Federico] Univ Malaga, Hosp Univ Reg Malaga, Inst Invest Biomed Malaga IBIMA, UGC Endocrinol & Nutr, Malaga 29009, Spain, [Rojo-Martinez, Gemma] Univ Malaga, Hosp Univ Reg Malaga, Inst Invest Biomed Malaga IBIMA, UGC Endocrinol & Nutr, Malaga 29009, Spain, [Olveira, Gabriel] Univ Malaga, Hosp Univ Reg Malaga, Inst Invest Biomed Malaga IBIMA, UGC Endocrinol & Nutr, Malaga 29009, Spain, [Rubio-Martin, Elehazara] Inst Salud Carlos III, Ctr Invest Biomed Red CIBERDEM CB07 08 0019, Malaga 29009, Spain, [Garcia-Escobar, Eva] Inst Salud Carlos III, Ctr Invest Biomed Red CIBERDEM CB07 08 0019, Malaga 29009, Spain, [Ruiz de Adana, Maria-Soledad] Inst Salud Carlos III, Ctr Invest Biomed Red CIBERDEM CB07 08 0019, Malaga 29009, Spain, [Bermudez-Silva, Francisco-Javier] Inst Salud Carlos III, Ctr Invest Biomed Red CIBERDEM CB07 08 0019, Malaga 29009, Spain, [Soriguer, Federico] Inst Salud Carlos III, Ctr Invest Biomed Red CIBERDEM CB07 08 0019, Malaga 29009, Spain, [Rojo-Martinez, Gemma] Inst Salud Carlos III, Ctr Invest Biomed Red CIBERDEM CB07 08 0019, Malaga 29009, Spain, [Olveira, Gabriel] Inst Salud Carlos III, Ctr Invest Biomed Red CIBERDEM CB07 08 0019, Malaga 29009, Spain, CAPRITEC-Tecnologias para la optimizacion de la sanidad, produccion y productos de la leche de cabra en Andalucia, FEDER-EU 'Una manera de hacer Europa', and INTERCONNECTA
Subjects: 0301 basic medicine, Male, goat dairy, cow dairy, satiety, appetite regulation, body weight control, metabolic profile, Amino-acid, Satiety Response, Food-intake, Normal-weight, chemistry.chemical_compound, 0302 clinical medicine, Insulin, Food science, media_common, Nutrition and Dietetics, Cross-Over Studies, Goats, digestive, oral, and skin physiology, food and beverages, Nutritive utilization, Ghrelin, Milk, Female, lcsh:Nutrition. Foods and food supply, Metabolic profile, Adult, media_common.quotation_subject, Casein, 030209 endocrinology & metabolism, lcsh:TX341-641, Biology, Article, 03 medical and health sciences, Species Specificity, Animals, Humans, Breakfast, 030109 nutrition & dietetics, Triglyceride, Protein, Appetite, Crossover study, Glucose, chemistry, Appetite hormones, Cattle, Dairy Products, Energy-intake, Food Science, Hormone
Abstract: The satiating effects of cow dairy have been thoroughly investigated; however, the effects of goat dairy on appetite have not been reported so far. Our study investigates the satiating effect of two breakfasts based on goat or cow dairy and their association with appetite related hormones and metabolic profile. Healthy adults consumed two breakfasts based on goat (G-Breakfast) or cow (C-Breakfast) dairy products. Blood samples were taken and VAS tests were performed at different time points. Blood metabolites were measured and Combined Satiety Index (CSI) and areas under the curves (AUC) were calculated. Desire to eat rating was significantly lower (breakfast & time interaction p < 0.01) and hunger rating tended to be lower (breakfast & time interaction p = 0.06) after the G-breakfast. None of the blood parameters studied were different between breakfasts; however, AUCGLP-1 was inversely associated with the AUChunger and AUCdesire-to-eat after the G-Breakfast, whereas triglyceride levels were directly associated with AUCCSI after the C-Breakfast. Our results suggest a slightly higher satiating effect of goat dairy when compared to cow dairy products, and pointed to a potential association of GLP-1 and triglyceride levels with the mechanisms by which dairy products might affect satiety after the G-Breakfast and C-Breakfast, respectively.
Published: 2017

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