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2018 OCT 13 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- Researchers detail new data in Eye Diseases and Conditions - Endophthalmitis. According [...]

Objective: To evaluate the potential of enzymatic detergents to cause endothelial damage and anterior segment inflammation. Methods: Paired rabbit corneas were mounted in an in vitro specular microscope. Endothelia were perfused either with the sterile irrigating solution BSS Plus (Alcon Laboratories Inc, Ft Worth, Tex) (control) or 0.1%, 0.4%, or 1.0% Medline Enzymatic Detergent (Medline Industries Inc, Mundelein, Ill) in BSS Plus. Swelling rates were determined by regression analysis. Human endothelia were perfused using 1.56% detergent. All corneas were fixed for scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Endothelial permeability was determined following perfusion of 0.78% detergent. Finally, in vivo intracameral injections with 1.56% or 3.9% detergent were performed to evaluate clinical changes and to correlate with histopathologic analysis. Results: Dose-related corneal swelling rates were observed. Digital specular micrographs revealed greater endothelial cell damage when perfused with 1.0% detergent. The TEM of endothelia exposed to 1.0% solutions demonstrated abnormal vacuolization and dilated extracellular spaces, which manifested as an increased corneal permeability to 3 to 4 times that of controls. Human corneas swelled comparably to rabbit corneas but demonstrated increased sensitivity when evaluated by TEM and SEM. Histopathologic analysis after intracameral injection revealed thickened corneas with fewer endothelial cells and irises with increased inflammatory and fibrinous responses compared with controls. Conclusions: Medline Enzymatic Detergent causes a dose-dependent corneal swelling, ultrastructural damage, increased corneal permeability, and increased inflammatory response in the iris after intracameral injection. Clinical Relevance: Failure to adequately rinse the detergent from surgical instruments may result in corneal edema and intraocular inflammation. Arch Ophthalmol. 2002;120:165-172

AUBURN HILLS, MI :: For patients required to receive repeat intravitreal injections, alleviating concerns about pain--as well as their actual pain--is a matter of a few simple, well-timed steps in [...]

Opko Health licenses device to prevent endophthalmitis By KAREN YOUNG Medical Device Daily Staff Writer Opko Health (Miami), which includes in its portfolio a retinal imaging device and an ophthalmic [...]

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajo.2005.04.015 Byline: Regis P. Kowalski (a)(b), Eric G. Romanowski (a)(b), Francis S. Mah (a)(b), Kathleen A. Yates (a)(b), Y. Jerold Gordon (a)(b) Abstract: To determine whether Vigamox[R] (moxifloxacin 0.5% ophthalmic solution) can be safely injected intracamerally to prevent Staphylococcus aureus endophthalmitis in a rabbit model. Author Affiliation: (a) Charles T. Campbell Ophthalmic Microbiology Laboratory at the University of Pittsburgh Medical Center; Pittsburgh, Pennsylvania (b) UPMC Eye Center, Ophthalmology and Visual Science Research Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Article History: Accepted 1 April 2005 Article Note: (footnote) This research project was supported by a grant from Alcon Laboratories, Inc, Fort Worth, Texas. The agreement between the University of Pittsburgh, Pittsburgh, Pennsylvania, and Alcon Laboratories states that the authors have the right to publish the data regardless of the study outcome. Alcon Laboratories did review the study protocol and were granted the courtesy to review the manuscript before submission but did not have any role in collection, management, analysis, and interpretation of the data. The authors are paid consulting fees from Alcon Laboratories (Ft. Worth, Texas).

Ocular treatment with flomoxef sodium (FMOX) and/or levofloxacin (LVFX) may prevent endophthalmitis following surgical cataract removal. In a recent study, ophthalmologists in Japan intravenously administered FMOX '120 minutes before cataract [...]

TORONTO PERIOPERATIVE ANTIBIOTICS --whether topical, subconjunctival, or intracameral--are used almost everywhere to prevent acute endophthalmitis, with varying protocols and evidence for efficacy. Intracameral antibiotics should be standard practice during cataract [...]

BALTIMORE :: POSTOPERATIVE ENDOPHTHALMITIS after cataract surgery is rare, but ophthalmologists can still take steps to alleviate its risk even further, according to Christina R. Prescott, MD, PhD. 'As [physicians] [...]

Dr. Donnenfeld holds co-directorships in the cornea and external disease departments at two New York hospitals, is surgical director for the Long Island Lions Eye Bank and medical director of [...]

1 Risk of intraocular foreign body is associated with mechanism of injury Accurate history-taking that involves attention to the mechanism of ocular injury should be obtained. High-risk mechanisms for intraocular [...]

Las Vegas -- Mthough logical arguments can be made to support the use of several strategies for limiting intraocular microbial contamination and minimizing the risk of postoperative endophthalmitis, a need [...]

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajo.2004.08.058 Byline: Wai-Man Chan (a), David T.L. Liu (a), Dorothy S.P. Fan (a), Teresa T.Y. Lau (a), Dennis S.C. Lam (a) Abstract: To report a rare presentation of bilateral, sequential Pseudomonas aeruginosa endogenous endophthalmitis in a woman with bronchiectasis. Author Affiliation: (a) Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, People's Republic of China. Article History: Accepted 24 August 2004

Fort Lauderdale, FL -- Results of testing in an animal model demonstrated that topical moxifloxacin 0.5% ophthalmic solution (Vigamox, Alcon Laboratories) provided effective prophylaxis against endophthalmitis following an intravitreal injection, [...]