317 results on '"English, Karen"'
Search Results
2. The ARDS microenvironment enhances MSC-induced repair via VEGF in experimental acute lung inflammation
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Tunstead, Courteney, Volkova, Evelina, Dunbar, Hazel, Hawthorne, Ian J., Bell, Alison, Crowe, Louise, Masterson, Joanne C., Dos Santos, Claudia C., McNicholas, Bairbre, Laffey, John G., and English, Karen
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- 2024
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3. Healthy versus inflamed lung environments differentially affect mesenchymal stromal cells
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Enes, Sara Rolandsson, Hampton, Thomas H, Barua, Jayita, McKenna, David H, dos Santos, Claudia C, Amiel, Eyal, Ashare, Alix, Liu, Kathleen D, Krasnodembskaya, Anna D, English, Karen, Stanton, Bruce A, Rocco, Patricia RM, Matthay, Michael A, and Weiss, Daniel J
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Rare Diseases ,Acute Respiratory Distress Syndrome ,Stem Cell Research - Nonembryonic - Human ,Lung ,Stem Cell Research ,Clinical Research ,1.1 Normal biological development and functioning ,2.1 Biological and endogenous factors ,Underpinning research ,Aetiology ,Inflammatory and immune system ,Bronchoalveolar Lavage Fluid ,Humans ,Mesenchymal Stem Cell Transplantation ,Mesenchymal Stem Cells ,Respiratory Distress Syndrome ,Medical and Health Sciences ,Respiratory System - Abstract
BackgroundDespite increased interest in mesenchymal stromal cell (MSC)-based cell therapies for acute respiratory distress syndrome (ARDS), clinical investigations have not yet been successful and our understanding of the potential in vivo mechanisms of MSC actions in ARDS remains limited. ARDS is driven by an acute severe innate immune dysregulation, often characterised by inflammation, coagulation and cell injury. How this inflammatory microenvironment influences MSC functions remains to be determined.AimThe aim of this study was to comparatively assess how the inflammatory environment present in ARDS lungs versus the lung environment present in healthy volunteers alters MSC behaviour.MethodsClinical-grade human bone marrow-derived MSCs (hMSCs) were exposed to bronchoalveolar lavage fluid (BALF) samples obtained from ARDS patients or from healthy volunteers. Following exposure, hMSCs and their conditioned media were evaluated for a broad panel of relevant properties, including viability, levels of expression of inflammatory cytokines, gene expression, cell surface human leukocyte antigen expression, and activation of coagulation and complement pathways.ResultsPro-inflammatory, pro-coagulant and major histocompatibility complex (self-recognition) related gene expression was markedly upregulated in hMSCs exposed ex vivo to BALF obtained from healthy volunteers. These changes were less apparent and often opposite in hMSCs exposed to ARDS BALF samples.ConclusionThese data provide new insights into how hMSCs behave in healthy versus inflamed lung environments, and strongly suggest that the inflamed environment in ARDS induces hMSC responses that are potentially beneficial for cell survival and actions. This further highlights the need to understand how different disease environments affect hMSC functions.
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- 2021
4. Human macrophage migration inhibitory factor potentiates mesenchymal stromal cell efficacy in a clinically relevant model of allergic asthma
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Hawthorne, Ian J., Dunbar, Hazel, Tunstead, Courteney, Schorpp, Tamara, Weiss, Daniel J., Enes, Sara Rolandsson, dos Santos, Claudia C., Armstrong, Michelle E., Donnelly, Seamas C., and English, Karen
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- 2023
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5. The human MIF polymorphism CATT7 enhances pro‐inflammatory macrophage polarization in a clinically relevant model of allergic airway inflammation
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Dunbar, Hazel, primary, Hawthorne, Ian J., additional, McNamee, Eóin N., additional, Armstrong, Michelle E., additional, Donnelly, Seamas C., additional, and English, Karen, additional
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- 2024
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6. The Unique Vulnerabilities of Children to Environmental Hazards
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English, Karen, Lau, Colleen, Jagals, Paul, and Xia, Yankai, editor
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- 2020
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7. The MSC-EV-microRNAome: A Perspective on Therapeutic Mechanisms of Action in Sepsis and ARDS
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dos Santos, Claudia C., primary, Lopes-Pacheco, Miquéias, additional, English, Karen, additional, Rolandsson Enes, Sara, additional, Krasnodembskaya, Anna, additional, and Rocco, Patricia R. M., additional
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- 2024
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8. Apoptotic MSCs, COX2/PGE2 and clinical efficacy in Crohn fistula
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English, Karen, primary
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- 2023
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9. Cyclosporine A and IFNγ licencing enhances human mesenchymal stromal cell potency in a humanised mouse model of acute graft versus host disease
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Corbett, Jennifer M., Hawthorne, Ian, Dunbar, Hazel, Coulter, Ivan, Chonghaile, Mairead Ni, Flynn, Catherine M., and English, Karen
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- 2021
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10. Mesenchymal stromal cells dampen trained immunity in house dust mite-primed macrophages expressing human macrophage migration inhibitory factor polymorphism
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Dunbar, Hazel, Hawthorne, Ian J., Tunstead, Courteney, McNamee, Eóin N., Weiss, Daniel J., Armstrong, Michelle E., Donnelly, Seamas C., and English, Karen
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- 2024
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11. The human MIF polymorphism CATT7 enhances pro‐inflammatory macrophage polarization in a clinically relevant model of allergic airway inflammation.
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Dunbar, Hazel, Hawthorne, Ian J., McNamee, Eóin N., Armstrong, Michelle E., Donnelly, Seamas C., and English, Karen
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- 2024
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12. Carbon monoxide licensing of MSCs enhances their efficacy through autophagy-mediated miRNA mechanisms
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Dunbar, Hazel, Hawthorne, Ian J., and English, Karen
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- 2024
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13. Apoptotic MSCs, COX2/PGE2 and clinical efficacy in Crohn fistula
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English, Karen and English, Karen
- Abstract
The clinical application of mesenchymal stromal cells (MSCs) has been approved for use in pediatric graft-versus-host disease (GvHD) and perianal fistulizing Crohn disease. MSCs have also been investigated in an array of other inflammatory disease indications. Despite promising results in patients who respond to MSC administration, a significant proportion of patients do not respond, and this has significantly dampened enthusiasm for MSC-based cell therapy. A better understanding of the mechanism of action (MOA) involved in the therapeutic effects of MSCs may help to stratify patients who will respond to MSC administration. In this issue of Molecular Therapy, Cheung et al. publish their findings on the role of caspase-mediated apoptosis of MSCs, leading to the release of immunosuppressive factors, including prostaglandin E2 (PGE2), which correlated with clinical responsiveness in Crohn's disease patients.1 The authors build upon on their previous study that identified a correlation between the induction of apoptosis mediated by peripheral blood mononuclear cells (PBMCs) from patients with GvHD who responded to MSC administration.2 In the present article, Cheung et al. demonstrate once again a correlation between apoptosis induction in MSCs and a role for cyclooxygenase 2 (COX2)/PGE2 in mediating immunosuppressive effects in patients with Crohn's disease who responded to MSC therapy.1 The significance of this study is that it identifies potential assays that could be used to stratify patients based on the capacity of patient PBMCs to induce MSC apoptosis and/or the use of PGE2 levels produced from PBMC-induced apoptotic MSCs.
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- 2023
14. Mucosal-Associated Invariant T Cells Are Altered in Patients with Hidradenitis Suppurativa and Contribute to the Inflammatory Milieu
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Gallagher, Catriona, primary, Mahon, Julie Mac, additional, O’Neill, Chloe, additional, Cassidy, Féaron C., additional, Dunbar, Hazel, additional, De Barra, Conor, additional, Cadden, Caoimhe, additional, Pisarska, Marta M., additional, Wood, Nicole A.W., additional, Masterson, Joanne C., additional, McNamee, Eoin N., additional, Schrumpf, Elisabeth, additional, English, Karen, additional, O’Shea, Donal, additional, Tobin, Anne Marie, additional, and Hogan, Andrew E., additional
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- 2022
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15. Addressing the Challenge of Autoimmunity in the Treatment of Diabetes with Stem Cells
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English, Karen, Wood, Kathryn J., and Fairchild, Paul J., editor
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- 2013
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16. List of Contributors
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Abecassis, Michael, primary, Abed, Ahmed, additional, Abelli, Massimo, additional, Ahmad, Sarwat, additional, Alessiani, Mario, additional, Alsharidi, Aynaa, additional, Altruda, Fiorella, additional, Amorese, Gabriella, additional, Angeletti, Andrea, additional, Angelico, Mario, additional, Angelico, Roberta, additional, Angelotti, Maria L., additional, Applegate, Robert J., additional, Atala, Anthony, additional, Attanasio, Chiara, additional, Axelrod, David, additional, Bababekov, Yanik, additional, Basu, Joydeep, additional, Becherucci, Francesca, additional, Belford, P. Matthew, additional, Benedetti, Enrico, additional, Benedetti, Valentina, additional, Benigni, Ariela, additional, Bertram, Timothy A., additional, Bestard, Oriol, additional, Blake, Joshua, additional, Boggi, Ugo, additional, Brasile, Lauren, additional, Bromberg, Jonathan S., additional, Brouard, Sophie, additional, Brovold, Matthew, additional, Burke, George W., additional, Busic, Mirela, additional, Butt, Zeeshan, additional, Caddeo, Silvia, additional, Calzone, Stefano, additional, Campistol, Josep M., additional, Carmagnola, Irene, additional, Carty, Fiona, additional, Castanares-Zapatero, Diego, additional, Chadjichristos, Christos E., additional, Chambers, Brooke E., additional, Chandran, Sindhu, additional, Chatziantoniou, Christos, additional, Chen, Ashton, additional, Chen, Linda, additional, Chen, Xiwu, additional, Chiono, Valeria, additional, Chiusa, Manuel, additional, Ciancio, Gaetano, additional, Ciardelli, Gianluca, additional, Coletti, Gino, additional, Coll, Elisabeth, additional, Collienne, Christine, additional, Colvin, Robert B., additional, Cortinovis, Monica, additional, Cosimi, A. Benedict, additional, Cravedi, Paolo, additional, D’Amico, Giuseppe, additional, Da Sacco, Stefano, additional, Danger, Richard, additional, Dantal, Jacques, additional, Davidson, Alan J., additional, De Chiara, Letizia, additional, De Fijter, Johannes W., additional, de la Rosa, Gloria, additional, Delmonico, Francis L., additional, Deng, Junhong, additional, Deurdulian, Corinne, additional, Dhal, Abritee, additional, Dionigi, Paolo, additional, Domínguez-Gil, Beatriz, additional, Drozdzik, Marek, additional, Dussaule, Jean-Claude, additional, Edgar, Lauren, additional, Egidi, Maria Francesca, additional, El Hennawy, Hany, additional, English, Karen, additional, Everly, Matthew J., additional, Fagoonee, Sharmila, additional, Famulari, Elvira Smeralda, additional, Farney, Alan C., additional, Figliuzzi, Marina, additional, Framarino-dei-Malatesta, Marialuisa, additional, Fumo, David E., additional, Gagliardini, Elena, additional, Gallon, Lorenzo, additional, Gandhi, Sanjay K., additional, Gautreaux, Michael D., additional, Geraedts, Anna, additional, Giannese, Domenico, additional, Giulianotti, Pier C., additional, Goligorsky, Michael S., additional, Griesemar, Adam, additional, Grinyó, Josep M., additional, Gruessner, Angelika C., additional, Gruessner, Rainer W.G., additional, He, Bulang, additional, Heher, Eliot, additional, Ho, Bing, additional, Hosgood, Sarah A., additional, Hotta, Kiyohiko, additional, Humar, Atul, additional, Humes, H. David, additional, Iaria, Giuseppe, additional, Imberti, Barbara, additional, Izpisua Belmonte, Juan Carlos, additional, Jochmans, Ina, additional, Katari, Ravi, additional, Kavvadas, Panagiotis, additional, Kawai, Tatsuo, additional, Kengla, Carlos, additional, Keys, Tristan, additional, Kidiyoor, Amritha, additional, Kidokoro, Kengo, additional, Kumar, Deepali, additional, Kutcher, Michael A., additional, Lai, Quirino, additional, Laterre, Pierre-François, additional, Lebbé, Céleste, additional, Legendre, Christophe, additional, Lennon, Rachel, additional, Li, Peng, additional, Lin, Jen-Jar, additional, Little, Melissa H., additional, Lu, Xiongbing, additional, Ludlow, John W., additional, Mahíllo, Beatriz, additional, Masereeuw, Rosalinde, additional, Matesanz, Rafael, additional, Matovinovic, Mirjana S., additional, Mazzinghi, Benedetta, additional, Mbiandjeu Toya, Serge Cedrick, additional, McEwen, Scott, additional, Melandro, Fabio, additional, Melchiorri, Loredana, additional, Menon, Madhav C., additional, Mirzazadeh, Majid, additional, Montag, Samantha, additional, Montgomery, Robert A., additional, Montiel, Virginie, additional, Montserrat, Nuria, additional, Morigi, Marina, additional, Morrill, Christian C., additional, Mourad, Michel, additional, Murphy, Sean V., additional, Murray, Patricia, additional, Nardo, Tiziana, additional, Netti, Paolo A., additional, Nguyen, Mark, additional, Nicholson, Michael L., additional, O’Callaghan, John M., additional, Ohler, Linda, additional, Orlando, Giuseppe, additional, Osafune, Kenji, additional, Oura, Tetsu, additional, Peired, Anna, additional, Peloso, Andrea, additional, Peng, Zhenzhen, additional, Perico, Norberto, additional, Perin, Laura, additional, Perrone, Vittorio, additional, Persad, Paul, additional, Peti-Peterdi, János, additional, Petrosyan, Astgik, additional, Pietrabissa, Andrea, additional, Pino, Christopher J., additional, Pirenne, Jacques, additional, Pisani, Francesco, additional, Ploeg, Rutger J., additional, Porrini, Esteban, additional, Pozzi, Ambra, additional, Pugliese, Alberto, additional, Pugliese, Luigi, additional, Rabelink, Ton J., additional, Rampino, Teresa, additional, Rees, Michael A., additional, Reinders, Marlies E.J., additional, Remuzzi, Andrea, additional, Remuzzi, Giuseppe, additional, Riquier-Brison, Anne, additional, Roca, Raquel G., additional, Rogers, Jeffrey, additional, Romagnani, Paola, additional, Rosales, Ivy A., additional, Rosenblum, Norman D., additional, Rota, Cinzia, additional, Ruggenenti, Piero, additional, Ruini, Francesca, additional, Sageshima, Junichiro, additional, El Salem, Fadi, additional, Sandal, Shaifali, additional, Sander, Veronika, additional, Santeramo, Ilaria, additional, Santos, Renato M., additional, Sarwal, Minnie, additional, Shah, Jigesh, additional, Shetty, Aneesha A., additional, Silengo, Lorenzo, additional, Siskind, Eric, additional, Skaro, Anton, additional, Snanoudj, Renaud, additional, Soker, Shay, additional, South, Andrew M., additional, Spasovski, Goce, additional, Stratta, Robert J., additional, Strom, Charles, additional, Stubenitsky, Bart, additional, Tamburrini, Riccardo, additional, Tang, Qizhi, additional, Tantissattamo, Ekamol, additional, Tasaki, Masayuki, additional, Tchelepi, Hisham, additional, Ticozzelli, Elena, additional, Traitanon, Opas, additional, Trillini, Matias, additional, Tzvetanov, Ivo, additional, Valentín, María O., additional, Vincenti, Flavio, additional, Vistoli, Fabio, additional, Vriend, Jelle, additional, Walker, Stephen J., additional, Wertheim, Jason A., additional, Williams, David F., additional, Wilm, Bettina, additional, Wilmer, Martijn J., additional, Wingert, Rebecca A., additional, Wittebole, Xavier, additional, Xia, Yun, additional, Xinaris, Christodoulos, additional, Yamada, Kazuhiko, additional, Yokoo, Takashi, additional, Yokote, Shinya, additional, Zandvliet, Maarten L., additional, Zent, Roy, additional, Zhang, Yuanyuan, additional, Zhao, David X., additional, Zhao, Lihui, additional, and Zhao, Susan Y., additional
- Published
- 2017
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17. The Immune Response to the Allograft
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Carty, Fiona, primary and English, Karen, additional
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- 2017
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18. Translating MSC Therapy in the Age of Obesity
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Boland, Lauren, primary, Bitterlich, Laura Melanie, additional, Hogan, Andrew E., additional, Ankrum, James A., additional, and English, Karen, additional
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- 2022
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19. Mucosal associated invariant T cells are altered in patients with Hidradenitis Suppurativa and contribute to the inflammatory milieu
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Gallagher, Catriona, Mahon, Julie Mac, O’Neill, Chloe, Cassidy, Féaron C., Dunbar, Hazel, De Barra, Conor, Cadden, Caoimhe, Pisarska, Marta M., Wood, Nicole, Masterson, Joanne C., McNamee, Eoin N., English, Karen, O’Shea, Donal, Tobin, Anne Marie, Hogan, Andrew E., Gallagher, Catriona, Mahon, Julie Mac, O’Neill, Chloe, Cassidy, Féaron C., Dunbar, Hazel, De Barra, Conor, Cadden, Caoimhe, Pisarska, Marta M., Wood, Nicole, Masterson, Joanne C., McNamee, Eoin N., English, Karen, O’Shea, Donal, Tobin, Anne Marie, and Hogan, Andrew E.
- Abstract
Mucosal Associated Invariant T cells are a population of “innate” T cells, which express the invariant T cell receptor (TCR) a chain Va7.2-Ja33 and are capable of robust rapid cytokine secretion, producing a milieu of cytokines including IFN-g and IL-17. MAIT cells have been reported in multiple human tissues including the gut, periphery and skin. On-going research has highlighted their involvement in numerous inflammatory diseases ranging from rheumatoid arthritis and obesity to psoriasis. Hidradenitis Suppurativa (H.S) is a chronic inflammatory disease of the hair follicles, resulting in painful lesions of apocrine-bearing skin. Several inflammatory cytokines have been implicated in the pathogenesis of H.S including IL-17. The role of MAIT cells in H.S is currently unknown. In this study we show for the first time, that MAIT cells are altered in the peripheral blood of patients with H.S, with reduced frequencies and an IL-17 cytokine bias. We show that CCL20 expression is elevated in lesions of patients with H.S, and MAIT cells can actively traffic towards lesions via CCL20. We show that MAIT cells can accumulate in the lesionsfrom patients with H.S. when compared to adjacent skin, with an IL-17 bias. We show that elevated IL-17, can be linked to the activation of dermal fibroblasts, promoting the expression of chemotactic signals including CCL20 and CXCL1. Finally, we show that targeting the IL-17A transcription factor RORyt robustly reduces IL-17 production by MAIT cells from patients with H.S. Collectively our data detailsIL-17 producing MAIT cells as a novel player in the pathogenesis of H.S and highlights the potential of RORyt inhibition as a novel therapeutic strategy.
- Published
- 2022
20. Helminth antigens modulate human PBMCs, attenuating disease progression in a humanised mouse model of graft versus host disease
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Healy, Marc, primary, Aldridge, Allison, additional, Glasgow, Arlene.M.A., additional, Mahon, Bernard P., additional, English, Karen, additional, and O'Neill, Sandra M., additional
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- 2022
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21. MAC attack: MSCs and macrophages join forces against chronic lung infection.
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Dunbar, Hazel, Hawthorne, Ian James, and English, Karen
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GRAFT versus host disease ,ANTIGEN presenting cells ,MACROPHAGE migration inhibitory factor ,STROMAL cells ,MESENCHYMAL stem cells ,MYCOBACTERIUM avium paratuberculosis - Published
- 2024
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22. The Inflammatory Lung Microenvironment; a Key Mediator in MSC Licensing
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Dunbar, Hazel, primary, Weiss, Daniel J, additional, Rolandsson Enes, Sara, additional, Laffey, John G, additional, and English, Karen, additional
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- 2021
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23. LSC - 2021 - Mesenchymal stromal cells reduce house dust mite induced allergic airway inflammation in a humanised MIF expressing mouse model
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Ian, Hawthorne, primary, Dunbar, Hazel, additional, Donnelly, Seamas, additional, and English, Karen, additional
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- 2021
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24. Of Most Excellent "Francie"
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English, Karen
- Published
- 2000
25. List of Contributors
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Afroze, Syeda H., primary, Alpini, Gianfranco, additional, Anderson, Eric C., additional, Atala, Anthony, additional, Badylak, Stephen F., additional, Baiguera, Silvia, additional, Baiocchi, Leonardo, additional, Baptista, Pedro M., additional, Bejarano-Pineda, Lorena, additional, Benedetti, Enrico, additional, Beraldi, Rosanna, additional, Berdichevski, Alexandra, additional, Bhuyan, Mohammod, additional, Bishop, Alex G., additional, Bitar, Khalil N., additional, Blose, Kory J., additional, Brasile, Lauren, additional, Braza, Faouzi, additional, Breuer, Christopher K., additional, Brouard, Sophie, additional, Brown, Bryan N., additional, Burke, George W., additional, Butler, Peter E., additional, Butler, Colin R., additional, Calderon, Damelys, additional, Cancedda, Ranieri, additional, Cantero Peral, Susana, additional, Carbone, Marco, additional, Castanares-Zapatero, Diego, additional, Castro Santa, Edward, additional, Chatenoud, Lucienne, additional, Chawla, Reema, additional, Chen, Linda, additional, Chiono, Valeria, additional, Ciancio, Gaetano, additional, Ciardelli, Gianluca, additional, Ciccarelli, Olga, additional, Collienne, Christine, additional, Corradini, Francesca, additional, Cortiella, Joaquin, additional, Cravedi, Paolo, additional, Cypel, Marcelo, additional, Da Sacco, Stefano, additional, Date, Hiroshi, additional, Davies, Paige S., additional, De Coppi, Paolo, additional, De Luca, Michele, additional, Dean, Ethan W., additional, Degauque, Nicolas, additional, Domínguez-Bendala, Juan, additional, Dubernard, Jean Michel, additional, ElBackly, Rania M., additional, English, Karen, additional, Fändrich, Fred, additional, Farney, Alan C., additional, Faulk, Denver M., additional, García-Arrarás, José E., additional, Gianello, Pierre, additional, Giangreco, Adam, additional, Glaser, Shannon S., additional, Gobble, Ryan, additional, Goldstein, Aaron S., additional, Grant, Christa N., additional, Grikscheit, Tracy C., additional, Gruessner, Angelika C., additional, Gruessner, Rainer W.G., additional, Guillot, Pascale V., additional, Hamilton, Nicholas, additional, Hantson, Philippe, additional, Hemal, Sij, additional, Hematti, Peiman, additional, Hynds, Robert E., additional, Inverardi, Luca, additional, Jacquet, Luc M., additional, Janes, Sam M., additional, Jell, Gavin, additional, Jensen, Kendal, additional, Jochmans, Ina, additional, Kanai, Nobuo, additional, Katari, Ravi, additional, Keshavjee, Shaf, additional, Kim, Jaehyup, additional, Kim, Yeonhee, additional, King, Nancy M.P., additional, Kobayashi, Eiji, additional, Koshiba, Takaaki, additional, Krawiec, Jeffrey T., additional, Kurobe, Hirotsugu, additional, Lai, Quirino, additional, Lanzoni, Giacomo, additional, Laterre, Pierre-François, additional, Lerut, Jan P., additional, Lerut, Toni, additional, Li, Ou, additional, Macchiarini, Paolo, additional, Maghsoudlou, Panagiotis, additional, Mamode, Nizam, additional, Manzia, Tommaso M., additional, Martinez-Fernandez, Almudena, additional, Martovetsky, Gleb, additional, Mastrogiacomo, Maddalena, additional, Masuda, Shigeo, additional, McQuilling, John P., additional, Mehra, Mandeep R., additional, Menasché, Philippe, additional, Meng, Fanyin, additional, Mironi-Harpaz, Iris, additional, Mirzazadeh, Majid, additional, Moiemen, Naiem S., additional, Moran, Emma, additional, Muiesan, Paolo, additional, Nardo, Tiziana, additional, Nelson, Timothy J, additional, Netti, Paolo A., additional, Neuberger, James M., additional, Nigam, Sanjay K., additional, Ohe, Hidenori, additional, Okano, Teruo, additional, Opara, Emmanuel C., additional, Orgill, Dennis P., additional, Otte, Jean-Bernard, additional, Ozer, Sinan, additional, Pareta, Rajesh A., additional, Patel, Timil, additional, Pellegrini, Graziella, additional, Peloso, Andrea, additional, Perin, Laura, additional, Petruzzo, Palmina, additional, Pinheiro, Rafael S., additional, Pirenne, Jacques, additional, Poindexter, Lauren K., additional, Pucéat, Michel, additional, Pugliese, Alberto, additional, Raghavan, Shreya, additional, Rahal, Kinan, additional, Rama, Paolo, additional, Remuzzi, Andrea, additional, Remuzzi, Giuseppe, additional, Reyna-Soriano, Daniel, additional, Rico Juri, Juan M., additional, Ricordi, Camillo, additional, Roberts, Keith J., additional, Rocco, Kevin A., additional, Rodriguez-Devora, Jorge I., additional, Rogers, Jeffrey, additional, Rudnick, David A., additional, Ruggenenti, Piero, additional, Sageshima, Junichiro, additional, Salvatori, Marcus, additional, Samavedi, Satyavrata, additional, Sannino, Alessandro, additional, Scalera, Irene, additional, Sedaghati, Tina, additional, Sedrakyan, Sargis, additional, Seifalian, Alexander M., additional, Seifalian, Amelia, additional, Seliktar, Dror, additional, Selvaggi, Gennaro, additional, Shapira-Schweitzer, Keren, additional, Shinoka, Toshiharu, additional, Shupe, Thomas, additional, Smith, Nicholas R., additional, Soulillou, Jean-Paul, additional, Spinelli, Valentina, additional, Sutherland, David E.R., additional, Tara, Shuhei, additional, Teratani, Takumi, additional, Terzic, Andre, additional, Thomas, Sunu S., additional, Tisone, Giuseppe, additional, Totonelli, Giorgia, additional, Tzakis, Andreas, additional, Tzvetanov, Ivo G., additional, Udelsman, Brooks V., additional, Uygun, Basak E., additional, Vacanti, Joseph P., additional, Van Caenegem, Olivier, additional, Van Dyke, Mark, additional, Van Raemdonck, Dirk E., additional, Vorp, David A., additional, Vyas, Dipen, additional, Wang, Kun, additional, Weinbaum, Justin S., additional, Wertheim, Jason A., additional, Williams, David F., additional, Wittebole, Xavier, additional, Wong, Melissa H., additional, Wood, Kathryn J., additional, Xu, Tao, additional, Yamato, Masayuki, additional, You, Sylvaine, additional, Yuan, Yuyu, additional, Zambon, Joao Paulo, additional, Zattoni, Michela, additional, and Zhu, Lei, additional
- Published
- 2014
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26. Stem Cell-Based Approach to Immunomodulation
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Wood, Kathryn J., primary, English, Karen, additional, and Li, Ou, additional
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- 2014
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27. IFN ‐γ and PPARδ influence the efficacy and retention of multipotent adult progenitor cells in graft vs host disease
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Carty, Fiona, primary, Dunbar, Hazel, additional, Hawthorne, Ian J., additional, Ting, Anthony E., additional, Stubblefield, Samantha R., additional, Van't Hof, Wouter, additional, and English, Karen, additional
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- 2021
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28. Additional file 1 of Cyclosporine A and IFNγ licencing enhances human mesenchymal stromal cell potency in a humanised mouse model of acute graft versus host disease
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Corbett, Jennifer M., Hawthorne, Ian, Dunbar, Hazel, Coulter, Ivan, Mairead Ni Chonghaile, Flynn, Catherine M., and English, Karen
- Abstract
Additional file 1: Supplementary Figure 1. CsA impairs MSC suppression of T cell proliferation in vitro. MSC were seeded (1 × 104 per well) into a 96 well round bottom plate followed by the addition of anti-CD3/CD28 bead (1 × 104 per well) activated CFSE labelled PBMCs (5 × 104 per well). Some groups were cultured in the presence of CsA (100, 500 or 1000 ng/ml). On day four, cells were harvested and stained with anti-CD3 and 7AAD viability dye to analyse CD3+ proliferation by flow cytometry. Statistical analysis was carried out using one way ANOVA Multiple Tukey comparison test and unpaired student t-test where *
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- 2021
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29. Healthy versus inflamed lung environments differentially affect mesenchymal stromal cells
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Rolandsson Enes, Sara, Hampton, Thomas H., Barua, Jayita, McKenna, David H., dos Santos, Claudia C., Amiel, Eyal, Ashare, Alix, Liu, Kathleen D., Krasnodembskaya, Anna D., English, Karen, Stanton, Bruce A., Rocco, Patricia R.M., Matthay, Michael A., Weiss, Daniel J., Rolandsson Enes, Sara, Hampton, Thomas H., Barua, Jayita, McKenna, David H., dos Santos, Claudia C., Amiel, Eyal, Ashare, Alix, Liu, Kathleen D., Krasnodembskaya, Anna D., English, Karen, Stanton, Bruce A., Rocco, Patricia R.M., Matthay, Michael A., and Weiss, Daniel J.
- Abstract
Background Despite increased interest in mesenchymal stromal cell (MSC)-based cell therapies for acute respiratory distress syndrome (ARDS), clinical investigations have not yet been successful and our understanding of the potential in vivo mechanisms of MSC actions in ARDS remains limited. ARDS is driven by an acute severe innate immune dysregulation, often characterised by inflammation, coagulation and cell injury. How this inflammatory microenvironment influences MSC functions remains to be determined. Aim The aim of this study was to comparatively assess how the inflammatory environment present in ARDS lungs versus the lung environment present in healthy volunteers alters MSC behaviour. Methods Clinical-grade human bone marrow-derived MSCs (hMSCs) were exposed to bronchoalveolar lavage fluid (BALF) samples obtained from ARDS patients or from healthy volunteers. Following exposure, hMSCs and their conditioned media were evaluated for a broad panel of relevant properties, including viability, levels of expression of inflammatory cytokines, gene expression, cell surface human leukocyte antigen expression, and activation of coagulation and complement pathways. Results Pro-inflammatory, pro-coagulant and major histocompatibility complex (self-recognition) related gene expression was markedly upregulated in hMSCs exposed ex vivo to BALF obtained from healthy volunteers. These changes were less apparent and often opposite in hMSCs exposed to ARDS BALF samples. Conclusion These data provide new insights into how hMSCs behave in healthy versus inflamed lung environments, and strongly suggest that the inflamed environment in ARDS induces hMSC responses that are potentially beneficial for cell survival and actions. This further highlights the need to understand how different disease environments affect hMSC functions.
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- 2021
30. Drug delivery formulation impacts cyclosporine efficacy in a humanised mouse model of acute graft versus host disease
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Corbett, Jennifer M., Hawthorne, Ian, Coulter, Ivan S., English, Karen, Corbett, Jennifer M., Hawthorne, Ian, Coulter, Ivan S., and English, Karen
- Abstract
Acute graft versus host disease (aGvHD) is an allogeneic T cell mediated disease which manifests as a severe inflammatory disease affecting multiple organs including the liver, skin, lungs and gastrointestinal tract. Existing prophylactic and therapeutic approaches in aGvHD include the use of cyclosporine A (CyA), however the currently approved CyA formulations which were designed to optimise systemic CyA bioavailability can have a number of side effects including nephrotoxicity as well as the potential to attenuate the beneficial Graft-versus-Leukemia (GvL) effect. An added complication with CyA is that it has a narrow therapeutic window, and following oral administration is absorbed only from the small intestine, with variable cytochrome P450 metabolism contributing to intra- and inter-patient variability. This study sought to investigate the efficacy of a novel CyA oral formulation enabled by the integrated SmPill® oral drug delivery platform in a humanised mouse model of aGvHD. The study compared the approved optimised CyA (Neoral®) with SmPill®-enabled CyA and a systemic intravenous CyA formulation. Our findings clearly demonstrate superior efficacy of the novel SmPill® CyA in prolonging survival in a clinically relevant humanised aGvHD model. SmPill® CyA significantly reduced pathological score in the small intestine, colon, liver and lung of aGvHD mice. In addition, SmPill® CyA significantly reduced the levels of pro-inflammatory cytokines in all the GvHD target tissues examined. Notably, SmPill® CyA was significantly more potent in reducing GvHD associated pathology and inflammatory cytokine production compared to the optimised approved oral CyA formulation, Neoral®.
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- 2021
31. Research Progress on Strategies that can Enhance the Therapeutic Benefits of Mesenchymal Stromal Cells in Respiratory Diseases With a Specific Focus on Acute Respiratory Distress Syndrome and Other Inflammatory Lung Diseases
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Rolandsson Enes, Sara, Krasnodembskaya, Anna D., English, Karen, Dos Santos, Claudia C., Weiss, Daniel J., Rolandsson Enes, Sara, Krasnodembskaya, Anna D., English, Karen, Dos Santos, Claudia C., and Weiss, Daniel J.
- Abstract
Recent advances in cell based therapies for lung diseases and critical illnesses offer significant promise. Despite encouraging preclinical results, the translation of efficacy to the clinical settings have not been successful. One of the possible reasons for this is the lack of understanding of the complex interaction between mesenchymal stromal cells (MSCs) and the host environment. Other challenges for MSC cell therapies include cell sources, dosing, disease target, donor variability, and cell product manufacturing. Here we provide an overview on advances and current issues with a focus on MSC-based cell therapies for inflammatory acute respiratory distress syndrome varieties and other inflammatory lung diseases.
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- 2021
32. Research Progress on Strategies that can Enhance the Therapeutic Benefits of Mesenchymal Stromal Cells in Respiratory Diseases With a Specific Focus on Acute Respiratory Distress Syndrome and Other Inflammatory Lung Diseases
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Rolandsson Enes, Sara, primary, Krasnodembskaya, Anna D., additional, English, Karen, additional, Dos Santos, Claudia C., additional, and Weiss, Daniel J., additional
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- 2021
- Full Text
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33. Drug delivery formulation impacts cyclosporine efficacy in a humanised mouse model of acute graft versus host disease
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Corbett, Jennifer M., primary, Hawthorne, Ian, additional, Coulter, Ivan S., additional, and English, Karen, additional
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- 2021
- Full Text
- View/download PDF
34. Healthy versus inflamed lung environments differentially affect mesenchymal stromal cells
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Rolandsson Enes, Sara, primary, Hampton, Thomas H., additional, Barua, Jayita, additional, McKenna, David H., additional, dos Santos, Claudia C., additional, Amiel, Eyal, additional, Ashare, Alix, additional, Liu, Kathleen D., additional, Krasnodembskaya, Anna D., additional, English, Karen, additional, Stanton, Bruce A., additional, Rocco, Patricia R.M., additional, Matthay, Michael A., additional, and Weiss, Daniel J., additional
- Published
- 2021
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35. Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells
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Abreu, Soraia C., Hampton, Thomas H., Hoffman, Evan, Dearborn, Jacob, Ashare, Alix, Singh Sidhu, Karatatiwant, Matthews, Dwight E., McKenna, David H., Amiel, Eyal, Barua, Jayita, Krasnodembskaya, Anna, English, Karen, Mahon, Bernard P., Dos Santos, Claudia, Cruz, Fernanda F., Chambers, Daniel C., Liu, Kathleen D., Matthay, Michael A., Cramer, Robert A., Stanton, Bruce A., Rocco, Patricia R. M., Wargo, Matthew J., Weiss, Daniel J., Rolandsson Enes, Sara, Abreu, Soraia C., Hampton, Thomas H., Hoffman, Evan, Dearborn, Jacob, Ashare, Alix, Singh Sidhu, Karatatiwant, Matthews, Dwight E., McKenna, David H., Amiel, Eyal, Barua, Jayita, Krasnodembskaya, Anna, English, Karen, Mahon, Bernard P., Dos Santos, Claudia, Cruz, Fernanda F., Chambers, Daniel C., Liu, Kathleen D., Matthay, Michael A., Cramer, Robert A., Stanton, Bruce A., Rocco, Patricia R. M., Wargo, Matthew J., Weiss, Daniel J., and Rolandsson Enes, Sara
- Abstract
Growing evidence demonstrates that human mesenchymal stromal cells (MSCs) modify their in vivo anti-inflammatory actions depending on the specific inflammatory environment encountered. Understanding this better is crucial to refine MSC-based cell therapies for lung and other diseases. Using acute exacerbations of cystic fibrosis (CF) lung disease as a model, the effects of ex vivo MSC exposure to clinical bronchoalveolar lavage fluid (BALF) samples, as a surrogate for the in vivo clinical lung environment, on MSC viability, gene expression, secreted cytokines, and mitochondrial function were compared with effects of BALF collected from healthy volunteers. CF BALF samples that cultured positive for Aspergillus sp. (Asp) induced rapid MSC death, usually within several hours of exposure. Further analyses suggested the fungal toxin gliotoxin as a potential mediator contributing to CF BALF-induced MSC death. RNA sequencing analyses of MSCs exposed to either Asp+ or Asp− CF BALF samples identified a number of differentially expressed transcripts, including those involved in interferon signaling, antimicrobial gene expression, and cell death. Toxicity did not correlate with bacterial lung infections. These results suggest that the potential use of MSC-based cell therapies for CF or other lung diseases may not be warranted in the presence of Aspergillus.
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- 2020
36. Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells
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Abreu, Soraia C., primary, Hampton, Thomas H., additional, Hoffman, Evan, additional, Dearborn, Jacob, additional, Ashare, Alix, additional, Singh Sidhu, Karatatiwant, additional, Matthews, Dwight E., additional, McKenna, David H., additional, Amiel, Eyal, additional, Barua, Jayita, additional, Krasnodembskaya, Anna, additional, English, Karen, additional, Mahon, Bernard, additional, Dos Santos, Claudia, additional, Cruz, Fernanda F., additional, Chambers, Daniel C., additional, Liu, Kathleen D., additional, Matthay, Michael A., additional, Cramer, Robert A., additional, Stanton, Bruce A., additional, Rocco, Patricia R. M., additional, Wargo, Matthew J., additional, Weiss, Daniel J., additional, and Rolandsson Enes, Sara, additional
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- 2020
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37. Addressing the Challenge of Autoimmunity in the Treatment of Diabetes with Stem Cells
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English, Karen, primary and Wood, Kathryn J., additional
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- 2012
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38. Mechanisms of mesenchymal stromal cell immunomodulation
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English, Karen
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- 2013
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39. Integrating your health problem
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English, Karen Trumbull and Lopez, Kimberly Weiss
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Workplace accidents -- Forecasts and trends -- Reports ,Workers' compensation -- Evaluation ,Business ,Human resources and labor relations ,Insurance ,Market trend/market analysis ,Evaluation ,Reports ,Forecasts and trends - Abstract
The least expensive workers compensation claim is the one that never happens. But many injuries occur in the workplace that could be prevented through early detection. The good news is [...]
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- 2007
40. The Necrobiology of Mesenchymal Stromal Cells Affects Therapeutic Efficacy
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Weiss, Daniel J., English, Karen, Krasnodembskaya, Anna, Isaza-Correa, Johana M., Hawthorne, Ian J., Mahon, Bernard P., Weiss, Daniel J., English, Karen, Krasnodembskaya, Anna, Isaza-Correa, Johana M., Hawthorne, Ian J., and Mahon, Bernard P.
- Abstract
Rapid progress is occurring in understanding the mechanisms underlying mesenchymal stromal cell (MSC)-based cell therapies (MSCT). However, the results of clinical trials, while demonstrating safety, have been varied in regard to efficacy. Recent data from different groups have shown profound and significant influences of the host inflammatory environment on MSCs delivered systemically or through organ-specific routes, for example intratracheal, with subsequent actions on potential MSC efficacies. Intriguingly in some models, it appears that dead or dying cells or subcellular particles derived from them, may contribute to therapeutic efficacy, at least in some circumstances. Thus, the broad cellular changes that accompany MSC death, autophagy, pre-apoptotic function, or indeed the host response to these processes may be essential to therapeutic efficacy. In this review, we summarize the existing literature concerning the necrobiology of MSCs and the available evidence that MSCs undergo autophagy, apoptosis, transfer mitochondria, or release subcellular particles with effector function in pathologic or inflammatory in vivo environments. Advances in understanding the role of immune effector cells in cell therapy, especially macrophages, suggest that the reprogramming of immunity associated with MSCT has a weighty influence on therapeutic efficacy. If correct, these data suggest novel approaches to enhancing the beneficial actions of MSCs that will vary with the inflammatory nature of different disease targets and may influence the choice between autologous or allogeneic or even xenogeneic cells as therapeutics.
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- 2019
41. Promoter function and in situ protein/DNA interactions upstream of the yeast HSP90 heat shock genes
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Gross, David S., Adams, Christopher C., English, Karen E., Collins, Kerry W., and Lee, Seewoo
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- 1990
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42. The Necrobiology of Mesenchymal Stromal Cells Affects Therapeutic Efficacy
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Weiss, Daniel J., primary, English, Karen, additional, Krasnodembskaya, Anna, additional, Isaza-Correa, Johana M., additional, Hawthorne, Ian J., additional, and Mahon, Bernard P., additional
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- 2019
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43. Chapter 18 - The Immune Response to the Allograft
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Carty, Fiona and English, Karen
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- 2017
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44. IFN‐γ and PPARδinfluence the efficacy and retention of multipotent adult progenitor cells in graft vs host disease
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Carty, Fiona, Dunbar, Hazel, Hawthorne, Ian J., Ting, Anthony E., Stubblefield, Samantha R., Van't Hof, Wouter, and English, Karen
- Abstract
Cell‐based therapy for the treatment of inflammatory disorders has focused on the application of mesenchymal stromal cells (MSCs) and multipotent adult progenitor cells (MAPCs). Despite the recent positive findings in industry‐sponsored clinical trials of MSCs and MAPCs for graft vs host disease (GvHD), cell therapy is efficacious in some but not all patients, highlighting the need to identify strategies to enhance cell‐based therapeutic efficacy. Here, we demonstrate the capacity for interferon (IFN)‐γ licensing to enhance human MAPC efficacy and retention following early administration in a humanized mouse model of acute GvHD (aGvHD). Activation of the nuclear receptor peroxisome proliferator‐activated receptor delta (PPARδ) negatively influenced the retention and efficacy of human MAPCs as well as IFN‐γ‐licensed MAPCs in the aGvHD model. PPARδ antagonism significantly enhanced the efficacy of human MAPCs when administered early in the humanized aGvHD model. COX‐2 expression in human MAPC was significantly decreased in IFN‐γ licensed MAPCs exposed to a PPARδ agonist. Importantly, MAPC exposure to the PPARδ antagonist in the presence of a COX‐2 inhibitor indomethacin before administration significantly reduced the efficacy of PPARδ antagonized MAPCs in the aGvHD humanized mouse model. This is the first study to demonstrate the importance of PPARδ in human MAPC efficacy in vivo and highlights the importance of understanding the disease microenvironment in which cell‐based therapies are to be administered. In particular, the presence of PPARδ ligands may negatively influence MAPC or MSC therapeutic efficacy. Interferon‐γ (IFN‐γ) licensing enhances the therapeutic efficacy of human multipotent adult progenitor cells (MAPCs) in a mouse model of acute graft vs host disease (aGvHD). Activation of peroxisome proliferator‐activated receptor (PPAR) δ reduces, whereas antagonism of PPARδ(−) enhances MAPC efficacy in aGvHD. PPARδ agonism reduces COX‐2 expression in IFN‐γ licensed MAPC. Figure created with BioRender.com.
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- 2021
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45. Multipotent Adult Progenitor Cells Suppress T Cell Activation in In Vivo Models of Homeostatic Proliferation in a Prostaglandin E2-Dependent Manner
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Carty, Fiona, primary, Corbett, Jennifer M., additional, Cunha, João Paulo M. C. M., additional, Reading, James L., additional, Tree, Timothy I. M., additional, Ting, Anthony E., additional, Stubblefield, Samantha R., additional, and English, Karen, additional
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- 2018
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46. Integrating absence management programs
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English, Karen Trumbull
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Human resource management -- Methods ,Worker absenteeism -- Management ,Company business management ,Business ,Human resources and labor relations - Abstract
Employers considering an integrated approach to absence management should look for providers who have experience, networks of resources such as physicians and rehab specialists, strong communication skills, proven implementation process protocols, effective data- and information-reporting capabilities, a willingness to work with other suppliers toward common goals, and the ability to measure and guarantee performance. The key for employers is to understand the forces driving the trends within their organizations, ask the right questions and find the right partner.
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- 2005
47. Abstracts from the Food Allergy and Anaphylaxis Meeting 2016
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Pouessel, Guillaume, Claverie, Claire, Labreuche, Julien, Renaudin, Jean-Marie, Dorkenoo, Aimée, Eb, Mireille, Moneret-Vautrin, Anne, Deschildre, Antoine, Leteurtre, Stephane, Grabenhenrich, Linus, Worm, Margitta, Dölle, Sabine, Scherer, Kathrin, Hutteger, Isidor, Christensen, Morten, Bindslev-Jensen, Carsten, Mortz, Charlotte, Eller, Esben, Kjaer, Henrik F, Carneiro-Leão, Leonor, Badas, Jenny, Coimbra, Alice, Levy, Dikla P, Ben-Shoshan, Moshe, Rimon, Ayelet, Benor, Shira, Arends, Nicolette J T, Edelbroek, Nikki, de Groot, Hans, Emons, Joyce A M, Brand, H. K A, Verhoeven, Dirk, van Veen, Leonieke N, de Jong, Nicolette W, Noh, Geunwoong, Jang, Eun H, Pascal, Mariona, Dominguez, Olga, Piquer, Mònica, Alvaro, Montserrat, Jimenez-Feijoo, Rosa, Lozano, Jaime, Machinena, Adriana, del Mar Folqué, Maria, Giner, Maria T, Plaza, Ana M, Turner, Paul, Patel, Nandinee, Vazquez-Ortiz, Marta, Lindsley, Sarah, Walker, Lucy, Rosenberg, Simon, Mari, Adriano, Alessandri, Claudia, Giangrieco, Ivana, Tuppo, Lisa, Rafaiani, Chiara, Mitterer, Georg, Ciancamerla, Michela, Ferrara, Rosetta, Bernardi, Maria L, Zennaro, Danila, Tamburrini, Maurizio, Ciardiello, Maria A, Harwanegg, Christian, Fernandez, Antonio, Selb, Regina, Egenmann, Philippe, Epstein, Michelle, Hoffmann-Sommergruber, Karin, Koning, Frits, Lovik, Martinus, Clare Mills, E. N, Moreno, Javier, van Loveren, Henk, Wal, Jean-Michel, Diesner, Susanne, Bergmayr, Cornelia, Pfitzner, Barbara, Assmann, Vera E, Starkl, Philipp, Endesfelder, David, Eiwegger, Thomas, Szepfalusi, Zsolt, Fehrenbach, Heinz, Jensen-Jarolim, Erika, Hartmann, Anton, Pali-Schöll, Isabella, Untersmayr, Eva, Wille, Soren, Meyer, Peter, Klingebiel, Caroline, Lidholm, Jonas, Ehrenberg, Angelica, Östling, Jonas, Cleach, Isabelle, Mège, Jean-Louis, Vitte, Joana, Aina, Roberta, Dubiela, Pawel, Pfeifer, Sabine, Bublin, Merima, Radauer, Christian, Humeniuk, Piotr, Kabasser, Stefan, Asero, Riccardo, Bogas, Gador, Gomez, Francisca, Campo, Paloma, Salas, Maria, Doña, Inmaculada, Barrionuevo, Esther, Guerrero, Maria A, Mayorga, Cristobalina, Prieto, Ana, Barber, Domingo, Torres, Maria J, Jamin, Annette, Wangorsch, Andrea, Ballmer, Barbara, Vieths, Stefan, Scheurer, Stephan, Apostolovic, Danijela, Mihailovic, Jelena, Krstic, Maja, Starkhammar, Maria, Velickovic, Tanja C, Hamsten, Carl, van Hage, Marianne, van Erp, Francine C, Knol, Edward F, Kansen, Hannah M, Pontoppidan, Bo, Meijer, Yolanda, van der Ent, Cornelis K, Knulst, André C, Sayers, Rebekah, Brown, Helen, Custovic, Adnan, Simpson, Angela, Mills, Claire, Schulz, Juliane, Akkerdaas, Jaap, Totis, Muriel, Capt, Annabelle, Herouet-Guicheney, Corinne, van Ree, Ronald, Banerjee, Tushar, Banerjee, Antima, Claude, Mathilde, Bouchaud, Grégory, Lupi, Roberta, Castan, Laure, Tranquet, Olivier, Denery-Papini, Sandra, Bodinier, Marie, Brossard, Chantal, De Poi, Rosella, Gritti, Elisa, De Dominicis, Emiliano, Popping, Bert, de Laureto, Patrizia P, Palosuo, Kati, Kukkonen, Anna K, Pelkonen, Anna, Mäkelä, Mika, Lee, Nanju A, Rost, Johanna, Muralidharan, Sridevi, Campbell, Dianne, Mehr, Sam, Nock, Catherine, Baumert, Joseph, Taylor, Steve, Mastrorilli, Carla, Tripodi, Salvatore, Caffarelli, Carlo, Perna, Serena, Di Rienzo Businco, Andrea, Sfika, Ifigenia, Dondi, Arianna, Bianchi, Annamaria, Dascola, Carlotta P, Ricci, Giampaolo, Cipriani, Francesca, Maiello, Nunzia, del Giudice, Michele M, Frediani, Tullio, Frediani, Simone, Macrì, Francesco, Pistoletti, Chiara, Iacono, Iride D, Patria, Maria F, Varin, Elena, Peroni, Diego, Comberiati, Pasquale, Chini, Loredana, Moschese, Viviana, Lucarelli, Sandra, Bernardini, Roberto, Pingitore, Giuseppe, Pelosi, Umberto, Olcese, Roberta, Moretti, Matteo, Cirisano, Anastasia, Faggian, Diego, Travaglini, Alessandro, Plebani, Mario, Verga, Maria C, Calvani, Mauro, Giordani, Paolo, Matricardi, Paolo M, Ontiveros, Noe, Cabrera-Chavez, Francisco, Galand, Julie, Beaudouin, Etienne, Pineau, Florence, Sakai, Shinobu, Matsunaga, Kayoko, Teshima, Reiko, Larré, Colette, Denery, Sandra, Tschirner, Sebastian, Trendelenburg, Valérie, Schulz, Gabriele, Niggemann, Bodo, Beyer, Kirsten, Bouferkas, Youcef, Belabbas, Younes, Saidi, Djamel, Kheroua, Omar, Mecherfi, Kamel E E, Guendouz, Malika, Haddi, Abir, Kaddouri, Hanane, Amaral, Luis, Pereira, Ana, Rodrigues, Susana, Datema, Mareen, Jongejan, Laurian, Clausen, Michael, Knulst, Andre, Papadopoulos, Nikolaos, Kowalski, Marek, de Blay, Frédéric, Zwinderman, Aeilko, Hoffman-Sommergruber, Karin, Ballmer-Weber, Barbara, Fernandez-Rivas, Montserrat, Deng, Shan, Yin, Jia, Eisenmann, Charlotte, Nassiri, Maria, Reinert, Rabea, van der Valk, Johanna P M, van Wijk, Roy G, Vergouwe, Yvonne, Steyerberg, Ewout W, Reitsma, Marit, Wichers, Harry J, Savelkoul, Huub F J, Vlieg-Boerstra, Berber, Dubois, Anthony E J, Carolino, Fabrícia, Rodolfo, Ana, Cernadas, Josefina, Roa-Medellín, Dasha, Rodriguez-Fernandez, Ana, Navarro, Joaquín, Albendiz, Vicente, Baeza, María L, Intente-Herrero, Sonsoles, Mikkelsen, Andrea, Mehlig, Kirsten, Lissner, Lauren, Verrill, Linda, Luccioli, Stefano, van Bilsen, Jolanda, Kuper, Frieke, Wolterbeek, André, Rankouhi, Tanja R, Verschuren, Lars, Cnossen, Hilde, Jeurink, Prescilla, Garssen, Johan, Knippels, Léon, Garthoff, Jossie, Houben, Geert, Leeman, Winfried, Eleonore Pettersson, M., Schins, Afke M M, Koppelman, Gerard H, Kollen, Boudewjin J, Zubchenko, Svitlana, Kuntz, Sarah, Mérida, Pablo, Álvaro, Montserrat, Piquer, Monica, Riggioni, Carmen, Castellanos, Juan H, Jimenez, Rosa, Cap, Melanie, Drumez, Elodie, Lejeune, Stéphanie, Thumerelle, Caroline, Mordacq, Clémence, Nève, Véronique, Ricò, Sonia, Varini, Margherita, Nocerino, Rita, Cosenza, Linda, Amoroso, Antonio, Di Costanzo, Margherita, Di Scala, Carmen, Bedogni, Giorgio, Canani, Roberto B, Turner, Paul J, Poza-Guedes, Paloma, González-Pérez, Ruperto, Sánchez-Machín, Inmaculada, Matheu-Delgado, Victor, Wambre, Erik, Ballegaard, Anne-Sofie, Madsen, Charlotte, Gregersen, Juliane, Bøgh, Katrine L, Aubert, Philippe, Neunlist, Michel, Magnan, Antoine, Lozano-Ojalvo, Daniel, Pablos-Tanarro, Alba, Pérez-Rodríguez, Leticia, Molina, Elena, López-Fandiño, Rosina, Rekima, Akila, Macchiaverni, Patricia, Turfkruyer, Mathilde, Holvoet, Sebastien, Dupuis, Lénaïck, Baiz, Nour, Annesi-Maesano, Isabella, Mercenier, Annick, Nutten, Sophie, Verhasselt, Valérie, Mrakovcic-Sutic, Ines, Banac, Srdan, Sutic, Ivana, Baricev-Novakovic, Zdenka, Sutic, Ingrid, Pavisic, Valentino, Muñoz-Cano, Rosa, Jiménez-Rodríguez, Teodoríkez, Corbacho, Daniel, Roca-Ferrer, Jordi, Bartra, Joan, Bulog, Aleksandar, Micovic, Vladimir, Markiewicz, Lidia, Szymkiewicz, Agata, Szyc, Anna, Wróblewska, Barbara, Harvey, Bryan M, Harthoorn, Lucien F, Wesley Burks, A., Rentzos, Georgios, Björk, Anna-Lena B, Bengtsson, Ulf, Barber, Colin, Kalicinsky, Chrystyna, Breynaert, Christine, Coorevits, Lieve, Jansen, Cornelia, Van Hoeyveld, Erna, Verbeke, Kristin, Kochuyt, Anne-Marie, Schrijvers, Rik, Deleanu, Diana, Muntean, Adriana, Konstantakopoulou, Maria, Pasioti, Maria, Papadopoulou, Anastasia, Iliopoulou, Anna, Mikos, Nikolaos, Kompoti, Evangelia, de Castro, Eunice D, Bartalomé, Borja, Ue, Kok L, Griffiths, Elizabeth, Till, Stephen, Grimshaw, Kate, Roberts, Graham, Selby, Anna, Butiene, Indre, Larco, Jose I, Dubakiene, Ruta, Fiandor, Ana, Fiocchi, Alessandro, Papadopoulos, Nikos, Sigurdardottir, Sigurveig, Sprikkelman, Aline, Schoemaker, Anne-Fleur, Xepapadaki, Paraskevi, Keil, Thomas, Cojocariu, Zizi, Barbado, Beatriz S, Iancu, Vasti, Arroabarren, Esozia, Esarte, Marta G, Arteaga, Miren, Andrade, Mayra C, Borges, Denise, Kalil, Jorge, Bianchi, Pedro G, Agondi, Rosana C, Gupta, Rinkesh K, Sharma, Akanksha, Gupta, Kriti, Das, Mukul, Dwivedi, Premendra, Karseladze, Rusudan, Jorjoliani, Liana, Saginadze, Lali, Tskhakaia, Mariam, Basello, Katia, Piuri, Gabriele, Speciani, Attilio F, Speciani, Michela C, Camerotto, Carla, Zinno, Francesco, Pakholchuk, Olga, Nedelska, Svitlana, Pattini, Stefano, Costantino, Maria T, Peveri, Silvia, Villalta, Danilo, Savi, Eleonora, Costanzi, Andrea, Revyakina, Vera A, Kiseleva, Marina A, Kuvshinova, Elena D, Larkova, Inna A, Shekhetov, Anton A, Silva, Diana, Moreira, André, Plácido, José, van der Kleij, Hanneke, van Twuijver, Esther, Sutorius, Robbert, de Kam, Pieter-Jan, van Odijk, Jenny, Lindqvist, Helen, Lustig, Elin, Jácome, Amyra A A, Aguilar, Karla L B, Domínguez, Miguel G, Hernández, David A M, Caruso, Cristiano, Casale, Cono, Rapaccini, Gian L, Romano, Antonino, De Vitis, Italo, Cocco, Renata R, Aranda, Carolina, Mallozi, Marcia C, Motta, Jackeline F, Moraes, Lilian, Pastorino, Antonio, Rosario, Nelson, Goudouris, Ekaterini, Porto, Arnaldo, Wandalsen, Neusa F, Sarinho, Emanuel, Sano, Flavio, Solé, Dirceu, Pitsios, Constantinos, Petrodimopoulou, Maria, Papadopoulou, Ekaterini, Passioti, Maria, Kontogianni, Meropi, Adamia, Nino, Khaleva, Ekaterina, del Prado, Ana P, Du Toit, George, Krzych, Edyta, Samolinska-Zawisza, Urszula, Furmanczyk, Konrad, Tomaszewska, Aneta, Raciborski, Filip, Lipiec, Agnieszka, Samel-Kowalik, Piotr, Walkiewicz, Artur, Borowicz, Jacek, Samolinski, Boleslaw, Nano, Aimee L, Recto, Marysia, Somoza, Maria L, López, Natalia B, Alzate, Diana P, Ruano, Francisco J, Garcimartín, Maria I, Haroun, Elisa, de la Torre, Maria V, Rojas, Antonia, Onieva, Montserrat L, 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M, Castenmiller, Jacqueline J M, Noteborn, Hub P J M, Houben, Geert F, Bravin, Kristian, Luyt, David, Javed, Bushra, Couch, Phil, Munro, Christopher, Padfield, Phil, Sperrin, Matt, Byrne, Aideen, Oosthuizen, Lizalet, Kelleher, Carina, Ward, Fiona, Brosnan, Niamh, King, Graham, Corbet, Eva, Guzmán, Josué A H, García, Montserrat B, Asensio, Oscar, Navarrete, Laura V, Larramona, Helena, Miró, Xavier D, Pyrz, Katarzyna, Austin, Moira, Boloh, Yanne, Couch, Philip, Galloway, Deirdre, Hernandez, Pilar, Hourihane, Jonathan O, Kenna, Fiona, Majkowska-Wojciechowska, Barbara, Regent, Lynne, Themisb, Marina, Schnadt, Sabine, Semic-Jusufagic, Aida, Galvin, Audrey D, Kauppila, Tiina, Kuitunen, Mikael, Kitsioulis, Nikolaos A, Douladiris, Nikolaos, Kostoudi, Sofia, Manolaraki, Ioanna, Mitsias, Dimitris, Manousakis, Emmanouil, Papadopoulos, Nikolaos G, Knibb, Rebecca, Hammond, Jennifer, Cooke, Richard, Yrjänä, Jaakko, Hanni, Anna-Maija, Vähäsarja, Päivi, Mustonen, Oona, Dunder, Teija, Kulmala, Petri, Lasa, Eva, D’Amelio, Carmen, Martínez, Sara, Joral, Alejandro, Gastaminza, Gabriel, Goikoetxea, Maria J, Candy, David C A, Van Ampting, Marleen T J, Oude Nijhuis, Manon M, Butt, Assad M, Peroni, Diego G, Fox, Adam T, Knol, Jan, Michaelis, Louise J, Padua, Ines, Padrao, Patricia, Moreira, Pedro, Barros, Renata, Sharif, Hanan, Ahmed, Manzoor, Gomaa, Nehad, Mens, Joris, Smit, Koen, Timmermans, Frans, Poredoš, Tomaž, Jeverica, Anja K, Sedmak, Marjeta, Benedik, Evgen, Accetto, Meta, Zupančič, Mirjana, Yonamine, Glauce, Soldateli, Gustavo, Aquilante, Bruna, Pastorino, Antonio C, de Moraes Beck, Cleonir L, Gushken, Andrea K, de Barros Dorna, Mayra, dos Santos, Cristiane N, Castro, Ana P M, Al-Qahtani, Abdulhadi, Arnaout, Rand, Khaliq, Agha R, Amin, Rashid, Sheikh, Farrukh, Alvarez, Jorge, Anda, Marta, Palacios, Miriam, De Prada, Montserrat, Ponce, Carmen, Balbino, Bianca, Sibilano, Riccardo, Marichal, Thomas, Gaudenzio, Nicolas, Karasuyama, Hajime, Bruhns, Pierre, Tsai, Mindy, Reber, Laurent L, Galli, Stephen J, Ferreira, Ana R, Cernadas, Josefina R, del Campo García, Aida, Fernández, Sara P, Carrera, Nerea S, Sánchez-Cruz, Fernando B, Lorenzo, José R F, Claus, Stephanie, Pföhler, Claudia, Ruëff, Franziska, Treudler, Regina, Jaume, Mercedes E, Madroñero, Agustin, Perez, Maria T G, Julia, Juan C, Plovdiv, Charlotte H, Gethings, Lee, Langridge, Jim, Adel-Patient, Karine, Bernard, Hervé, Barcievic-Jones, Ivona, Sokolova, Raditsa, Yankova, Rumyana, Ivanovska, Mariya, Murdjeva, Marianna, Popova, Tatyana, Dermendzhiev, Svetlan, Karjalainen, Martin, Lehnigk, Ulrike, Brown, Duncan, Locklear, Julie C, Locklear, Julie, Maris, Ioana, Hourihane, Jonathan, Ornelas, Cristina, Caiado, Joana, Ferreira, Manuel B, Pereira-Barbosa, Manuel, Puente, Yolanda, Daza, Juan C, Monteseirin, Francisco J, Ukleja-Sokolowska, Natalia, Gawronska-Ukleja, Ewa, Zbikowska-Gotz, Magdalena, Bartuzi, Zbigniew, Sokolowski, Lukasz, Adams, Aine, Mahon, Bernard, English, Karen, Gourdon-Dubois, Nelly, Sellam, Laetitia, Pereira, Bruno, Michaud, Elodie, Messaoudi, Khaled, Evrard, Bertrand, Fauquert, Jean-Luc, Palomares, Francisca, Gomez, Gador, Rodriguez, Maria J, Galindo, Luisa, Molina, Ana, Paparo, Lorella, Mennini, Maurizio, Aitoro, Rosita, Wawrzeńczyk, Adam, Przybyszewski, Michał, Wawrzeńczyk, Anna, Sarıcoban, Hulya E, Ugras, Meltem, Yalvac, Zerrin, Flokstra-de Blok, Bertine M J, van der Velde, J. L, Vereda, Andrea, Ippolito, Clara, Traversa, Amaranta, Adriano, Daniela, Bianchi, Daniela M, Gallina, Silvia, Decastelli, Lucia, Makatsori, Melina, Miles, Anne, Devetak, Sonja P, Devetak, Iztok, Tabet, Soraya A, Trandbohus, Jeanette F, Winther, Pernille, Malling, Hans-Jørgen, Hansen, Kirsten S, Garvey, Lene H, Wang, Chia-Chi, Cheng, Yin-Hua, Tung, Chun-Wei, Dietrich, Mariola, Marenholz, Ingo, Kalb, Birgit, Grosche, Sarah, Blümchen, Katharina, Schlags, Rupert, Price, Mareike, Rietz, Sylke, Esparza-Gordillo, Jorge, Lau, Susanne, Lee, Young-Ae, Almontasheri, Ali, Bahkali, Mohammad A, Elshorbagi, Sahar, Alfhaid, Abdullah, Altamimi, Mashary, Madbouly, Eman, Al-Dhekri, Hassan, Arnaout, Rand K, Basagaña, Maria, Miquel, Sira, Bartolomé, Borja, Brix, Bettina, Rohwer, Stefanie, Brandhoff, Sandra, Berger, Alena, Suer, Waltraud, Weimann, Alf, Bueno, Cristina, Martín-Pedraza, Laura, Abián, Sara, Segundo-Acosta, Pablo S, López-Rodríguez, Juan C, Barderas, Rodrigo, Batanero, Eva, Cuesta-Herranz, Javier, Villalba, María T, Correia, Magna, Benito-Garcia, Filipe, Arêde, Cristina, Piedade, Susana, Morais-Almeida, Mário, Hindley, James, Yarham, Ross, Kuklinska-Pijanka, Anna, Gillick, David, Patient, Karine, Chapman, Martin D, Miranda, Ana, Matos, Eugénia, Sokolova, Anna, Rao, Huan, Baricevic-Jones, Ivona, Smith, Frances, Xue, Wentong, Magnusdottir, Helga, Vidarsdottir, Anna G, Lund, Sigrun, Jensen, Anders B, Ludviksson, Bjorn R, Simon, Reyna, Elfont, Robert, Bennett, Sean, Voyksner, Robert, de Lurdes Torre, Maria, Yürek, Songül, Faber, Margaretha A, Bastiaensen, Annick, Mangodt, Evelyne, van Gasse, Athina, Decuyper, Ine, Sabato, Vito, Hagendorens, Margo M, Bridts, Chris H, De Clerck, Luc S, Ebo, Didier, Schwarz, Susanne, Ziegert, Mandy, Albroscheit, Saskia, Schwager, Christian, Kull, Skadi, Behrends, Jochen, Röckendorf, Niels, Schocker, Frauke, Frey, Andreas, Homann, Arne, Becker, Wolf-Meinhard, Jappe, Uta, Zaabat, Nesrine, Osscini, Sylvia, Agabriel, Chantal, Sterling, Benoît, Carsin, Ania, Liabeuf, Valérie, Maćków, Monica, Zbróg, Alina, Bronkowska, Monica, Courtois, Justine, Gadisseur, Romy, Bertholet, Catherine, Lukas, Pierre, Cavalier, Etienne, Delahaut, Philippe, Quinting, Birgit, Gertmo, Margareta B, Hasseus, Ewa T, Barzylovych, Vladyslava, Oliveira, Júlio, Ensina, Luis F, Aranda, Carolina S, Dopazo, Leire, Lopez, Rebeca, Perez, Raquel, Santos-Diez, Laura, Bilbao, Agurtzane, Garcia, Juan M, Núñez, Ignacio G, Mármol, María Á A, Villarejo, María J B, Martos, José A B, Vergara, Marina S, García, José M I, Michalska, Agata, Sergiejko, Grzegorz, Zacniewski, Robert, Ghiordanescu, Ileana-Maria, Deaconu, Cristina, Popescu, Mihaela, Bumbacea, Roxana S, Ibranji, Alkerta, Nikolla, Elida, Loloci, Gjustina, Juel-Berg, Nanna, Larsen, Lau F, Poulsen, Lars K, Marcelino, João, Prata, Ricardo, Costa, Ana C, Duarte, Fátima, Neto, Marta, Santos, Jennifer, Pestana, Luís C, Sampaio, Daniel, Minale, Paola, Dignetti, Paola, Bignardi, Donatella, Nedelea, Irena, Popescu, Florin-Dan, Vieru, Mariana, Secureanu, Florin-Adrian, Ganea, Carmen S, Vieira, Miguel, Silva, José P M, Watts, Timothy, Watts, Sophia, Lomikovska, Marta, Peredelskaya, Marina, Nenasheva, Natalia, Filipovic, Ivana, Zivkovic, Zorica, Filipovic, Djordje, Higgs, Jennette, Warner, Amena, and Jones, Carla
- Published
- 2017
48. The influence of macrophages on mesenchymal stromal cell therapy: passive or aggressive agents?
- Author
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Carty, Fiona, Mahon, Bernard P., English, Karen, Carty, Fiona, Mahon, Bernard P., and English, Karen
- Abstract
Mesenchymal stromal cells (MSC) have emerged as promising cell therapies for multiple conditions based on demonstrations of their potent immunomodulatory and regenerative capacities in models of inflammatory disease. Understanding the effects of MSC on T cells has dominated the majority of work carried out in this field to date; recently, however, a number of studies have shown that the therapeutic effect of MSC requires the presence of macrophages. It is timely to review the mechanisms and manner by which MSC modulate macrophage populations in order to design more effective MSC therapies and clinical studies. A complex crosstalk exists through which MSC and macrophages communicate, a communication that is not controlled exclusively by MSC. Here, we examine the evidence that suggests that MSC not only respond to inflammatory macrophages and adjust their secretome accordingly, but also that macrophages respond to encounters with MSC, creating a feedback loop which contributes to the immune regulation observed following MSC therapy. Future studies examining the effects of MSC on macrophages should consider the antagonistic role that macrophages play in this exchange.
- Published
- 2017
49. Human mesenchymal stromal cells exert HGF dependent cytoprotective effects in a human relevant pre-clinical model of COPD
- Author
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Kennelly, Helen, primary, Mahon, Bernard P., additional, and English, Karen, additional
- Published
- 2016
- Full Text
- View/download PDF
50. Mesenchymal stem cells to promote islet transplant survival
- Author
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English, Karen, primary
- Published
- 2016
- Full Text
- View/download PDF
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