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The clinical case is described of a 46-year-old patient, attended at the Traumatology office of the Centro de Diagnóstico Integral de Chuao, Baruta municipality, Miranda state, Venezuela, who suffered a right leg injury as a result of an accident at the mechanic workshop where he worked. He went for consultation a week after the accident with a compartment syndrome of the anteroexternal region of the leg. A wound with stitches in the affected area attracted attention. Radiographic studies confirmed the presence of a large shear disc fragment. The fragment was removed under regional anesthesia and after 6 weeks she returned to her usual work activities.

Objetivo: durante los últimos años, las actividades de ciencia ciudadana han cobrado mayor interés, debido a que contribuyen a la recopilación de nueva información y a generar nuevas preguntas de investigación. El propósito de este trabajo es presentar un ejercicio de ciencia ciudadana enfocado en la evaluación de la calidad del aire y la caracterización de microfauna acuática del humedal Juan Amarillo de la ciudad de Bogotá. Métodos: se diseñó un estudio longitudinal desde la perspectiva de la ciencia ciudadana que involucró mediciones de material particulado 2,5 (PM2,5) en la ciclorruta del humedal Juan Amarillo. El recorrido fue dividido en dos zonas. Se realizó una caracterización de la microfauna acuática residente en el humedal mediante observación con microscopio óptico y estereoscopio. Resultados: las concentraciones de PM2,5 fueron significativamente mayores en la zona 1 comparadas con las de la zona 2 (p < 0,001). Se identificaron diferentes especies de macroinvertebrados pertenecientes a los grupos Gastropoda, Oligochaeta, Hirudínea. Conclusiones: se estableció una relación entre la concentración de PM2,5 y las condiciones ambientales de la ruta. Se identificaron algunos microorganismos que podrían ser usados como bioindicadores de la calidad del agua. Las actividades de ciencia ciudadana pueden ser útiles para acercar a niños(as) a la ciencia.

The case report of a 26 years patient is described. He was assisted in the Orthopedics and Traumatology Service of Salvador Allende Integral Diagnostic Center from Caracas, in the Bolivian Republic of Venezuela who had received a shotgun shot in the posterior face of both thighs 6 months ago. This time he went to visit the doctor with intense pain in the left inferior member, mainly below the knee, accompanied by paresthesias in the innervation area of both bifurcation branches of the sciatic nerve. It could be demonstrated that the young man presented multiple projectile impacts in the posterior face of both thighs and halting march. The radiographic studies confirmed the presence of 8 projectiles, two in the right thigh and 6 in the left one. In the lateral view it was observed that one of them was at a depth that matched with the anatomical region of the left sciatic nerve. Local anesthesia, sedation and an images intensifier were used for the operation. The projectile located in the epineurium of the sciatic nerve could be removed with the patient cooperation without complications. After 3 months the discomfort had disappeared and he could return to his usual activities.

Resumen El sindrome neuroleptico maligno (SNM) es una condicion de hipersensibilidad a medicamentos neurolepticos de presentacion infrecuente, pero de alta letalidad dependiente de la sospecha del cuadro desde la perspectiva clinica y analisis del historial clinico-antecedentes. Se reporta un caso de paciente en su quinta decada de la vida con consumo de clozapina para manejo de crisis de ansiedad desde hace un mes, quien tras presentar una caida desde su propia altura, sufre trauma craneoencefalico moderado e inicia con sintomas compatibles con un SNM con evolucion torpida y fallecimiento a los nueve dias. Se destaca la evolucion rapidamente fatal, reconociendo la importancia de la vigilancia o sospecha clinica de esta entidad con el objetivo de reducir la morbimortalidad.

Introduction The habit of consuming energy drinks is a life-threatening risk, because it can produce a syndrome characterised by a muscle necrosis. This promotes the release of enzymes and myoglobin from inside the myocyte into the circulation, creating lipid peroxidation and leading to acute kidney injury, and hyperkalaemia, together producing rhabdomyolysis. Rhabdomyolysis can be expected to be found within 24–48 h after strenuous activities, even more so with a modified BORG index greater than or equal to 5 points. However, energy drinks, due to their high content of caffeine and other components, can generate this little known adverse event. Clinical case A 37-year-old patient admitted to the emergency department due to clinical symptoms of myalgia, and dark urine that appeared 24 h after four days of low-intensity muscular exercises, and was associated with daily consumption of an energizing drink for 2 years. The diagnosis of rhabdomyolysis was confirmed by increased creatine kinase and transaminases. It was not possible to measure myoglobin levels. The patient was treated with aggressive fluid therapy. He never presented with any renal or electrolyte complications. Conclusion This case highlights the appearance of acute rhabdomyolysis in patients taking low intensity exercises, and not ruling out long-term consumption of energy drinks as the main cause. There are few cases currently reported in the literature. Owing to the timely treatment, progression to acute kidney injury was avoided.

Resumen Introduccion Un riesgo potencialmente mortal es el habito de consumo de bebidas energizantes, porque puede producir un sindrome caracterizado por la necrosis muscular que promueve la liberacion de enzimas y mioglobina proveniente del interior del miocito hacia la circulacion, creando una peroxidacion lipidica llegando a generar lesion renal aguda e hiperkalemia; conocido como rabdomiolisis. La rabdomiolisis la esperariamos encontrar entre 24 y 48 h despues de actividades extenuantes, aun mas con un indice de Borg modificado mayor o igual a 5 puntos; sin embargo, las bebidas energizantes por su alto contenido de cafeina y otros componentes pueden generar este evento adverso poco conocido. Caso clinico Paciente de 37 anos, obeso, que ingreso al servicio de urgencias por cuadro clinico de mialgia y orina oscura que aparecio 24 h despues de 4 dias de ejercicio muscular de baja intensidad, asociado a consumo diario de bebida energizante por 2 anos. El diagnostico de rabdomiolisis se confirmo por hiperCKemia e hipertrasaminemia; no fue posible medir los niveles de mioglobina. El paciente fue tratado con fluidoterapia agresiva. Nunca presento complicaciones renales ni hidroelectroliticas. Conclusion Nuestro caso destaca la aparicion de rabdomiolisis aguda en pacientes sometidos a ejercicios de baja intensidad no descartando como causa principal el consumo cronico de bebidas energizantes. Son pocos casos actualmente reportados en la literatura. Gracias al tratamiento oportuno se evito la progresion a lesion renal aguda.

The case report of a 58 years patient is described. She went to the Orthopedics and Traumatology Service of Dr. Juan Bruno Zayas Alfonso Teaching General Hospital in Santiago de Cuba because she began to notice progressive increase of volume in the back of the left hand around 5 years ago, near the metacarpusphalangic articulation of the third finger that made its extension difficult and was unsightly. By means of the scan, a well defined echogenic image that infiltrated the thickness of the tendon was observed, reason why the exeresis of the tumor was carried out. The infiltration of this tendon was confirmed, which was dried up and substituted with self-graft of the accessory tendon that sends the ring finger tendon. The results of the histologic studies reported that it was a giant cell tumor of the sheath with tendinous infiltration. The hand was immobilized during 3 weeks and the functional recovery was completed at 45 days.

Background The efficacy of a combination of nimotuzumab, a humanized monoclonal antibody to the epidermal growth factor receptor, with chemoradiation in locally advanced head and neck squamous cell carcinoma (HNSCC) was evaluated in a phase II study. Methods Patients with stage III/IV HNSCC received 3-weekly cisplatin 100 mg/m2 for three cycles and weekly nimotuzumab 200 mg for 8 weeks concurrently with radiotherapy. Primary endpoint was best overall response (BOR) and secondary endpoint was progression-free survival (PFS). Results Thirty-seven patients were included; the majority were Chinese (76%), male (89%), and had stage IVA/IVB HNSCC (92%). BOR of complete and partial response was seen in 22/37 (59%) and 10/37 (27%) patients, respectively. Median PFS was 17.5 months (95% CI: 11.1-54.5) and 3-year PFS was 40.4% (95% CI: 24.3-55.9). The frequency and type of adverse events observed were similar to standard chemoradiation. Conclusion The combination of nimotuzumab with cisplatin and radiotherapy was safe and achieved high response rates in HNSCC.

En un sistema de mantenimiento preventivo programado por tiempo, se plantea la necesidad de optimizar el uso de los recursos del área de mantenimiento, para buscar un equilibrio a lo largo del periodo de planificación. El problema se refiere a la secuenciación de tareas en la que se requiere determinar la semana inicial del programa de mantenimiento para cada una de las actividades en las máquinas. Se propone un algoritmo genético que tiene como función objetivo minimizar el máximo tiempo de mantenimiento semanal, de tal manera que cumpla con las condiciones de la programación establecida en cuanto a duraciones y frecuencias. Se consigue un programa eficiente y equilibrado que mejora significativamente el uso de los recursos. Para futuros trabajos, se sugiere aplicar otras técnicas inteligentes para la solución del problema y formularlo teniendo en cuenta otras condiciones, como los diferentes tipos de mantenimiento o la minimización de las paradas frecuentes de los equipos.

Highlights • COVID-19 pandemic has disrupted our normal healthcare system. • To separate cancer patients undergoing chemotherapy from the main hospital, a religious facility was used in the interim. • The use of a religious facility is feasible as long as standard infection control polices are enforced., The advent of the COVID-19 pandemic has stretched most healthcare systems to the point that if no adaptations are made, failure will most likely happen. The Philippine healthcare system, with its meager resources, is very much vulnerable to this. During the start of the pandemic, Bataan General Hospital and Medical Center has been converted to a COVID-19 hub, leaving cancer care and treatment displaced. We describe our experience in the feasibility of using a religious facility as an interim place for continuing oncology treatment. An outpatient chemotherapy unit was set up using the main hall of the Residencia Sacerdotal, a religious facility, in Bataan. General practices for infection control, workflow and service delivery were in accordance with existing guidelines. A total of 56 adult patients and 22 pediatric patients were seen for chemotherapy during the period of April 28 to July 15, 2020. A total of 144 chemotherapy sessions for adults and 190 sessions for pediatric patients were done. Fifty nine patients (43 adults and 16 pediatric) were tested for COVID-19 RT PCR (GeneXpert®), as baseline prior to chemotherapy, and all were negative. During the course of treatment, adverse events were noted including infusion reactions, hematologic complications which resolved without any complications. No nosocomial infection was recorded both for patients and healthcare workers. To conclude, in the COVID-19 Pandemic Era adapting to the situation is the best way forward. In our setting, continuing cancer care in a religious facility is a feasible alternative.

Se presenta el caso clínico de un paciente de 58 años de edad, quien fue atendido en el Servicio de Ortopedia y Traumatología del Hospital General Docente "Dr. Juan Bruno Zayas Alfonso" de Santiago de Cuba por presentar aumento de volumen en la cara posterior del muslo izquierdo, de consistencia pétrea y adherida a planos profundos, no doloroso a la palpación superficial y profunda, además de parestesia en muslo y pierna izquierdos. Los resultados de los estudios clínicos, imagenológicos e histopatológicos efectuados permitieron diagnosticar un rabdomiosarcoma pleomórfico, para lo cual se indicó tratamiento médico y quirúrgico, así como seguimiento por oncología

Se describe el caso clínico de un comerciante de 78 años de edad, de procedencia haitiana, quien presentaba, desde hacía 7 meses, rigidez al flexionar la articulación interfalángica proximal y medial del cuarto dedo de la mano izquierda, contractura de la aponeurosis palmar y nódulos. Se le realizó fasciectomía parcial o subtotal y egresó a las 72 horas con buena evolución posoperatoria

Se realizó un estudio longitudinal, prospectivo, unicéntrico y analítico de tipo caso-control de 33 pacientes con retardo en la consolidación de las fracturas de tibia tratados con fijadores externos, atendidos en el Hospital General Docente "Dr. Juan Bruno Zayas Alfonso" de Santiago de Cuba, desde enero hasta diciembre de 2012, con vistas a identificar los factores de riesgo asociados. Para validar los resultados se calculó la razón de productos cruzados y se utilizaron la prueba de Ji al cuadrado y el test de Fisher con el correspondiente intervalo de confianza. Entre dichos factores predominaron el inadecuado seguimiento y control, el uso estático de los fijadores externos, el peroné intacto, el consumo prolongado de antiinflamatorios no esteroideos y tener 40 años y más, en ese orden.

Se realizó un estudio descriptivo, longitudinal y prospectivo para evaluar la eficacia de la técnica de incisión mínima en el tratamiento de 216 pacientes con síndrome de túnel carpiano, atendidos en el Centro de Diagnóstico Integral "El Bajo" perteneciente al municipio San Francisco, Maracaibo, Estado de Zulia, República Bolivariana de Venezuela, desde enero de 2008 hasta diciembre de 2011. Entre los principales hallazgos predominaron el grupo etario de 41-50 años (52,3 %), el sexo femenino (58,7 %) y el grupo II de la clasificación clínica de Dawson (68,5 %). Los síntomas desaparecieron en 72,2 % de los afectados, lo cual demuestra que los resultados fueron satisfactorios.

Objectives: Malnutrition is prevalent among cancer patients, and maybe correlated with altered quality of life. The objective of this study is to determine whether quality of life among cancer patients on chemotherapy at the National Kidney and Transplant Institute- Cancer Unit differs from patients with normal nutrition based on the Subjective Global Assessment scale.Methods: A cross sectional study was conducted among cancer patients admitted for chemotherapy at the National Kidney and Transplant Institute-Cancer Unit from January to May 2011. Demographic profile, performance status by Eastern Cooperative Oncology Group performance scale, nutritional status assessment by Subjective Global Assessment, and quality of life assessment by the European Organization for Research and Treatment of Cancer QoL-30 core module were obtained. Descriptive statistics and ANOVA were performed for analysis of quality of life parameters and nutritional status.Results: A total of 97 subjects were included in this study, 66 subjects (68.04%) were females and 31 (31.96%) were males. Mean age was 54.55 ± 11.14 years, while mean performance status by the Eastern Cooperative Oncology Group classification was 0.88 ± 0.83 with a range of 0-3. According to the Subjective Global Assessment, there were 58 patients with SGA A, classified to have adequate nutrition, and 39 patients (40.21%) were considered malnourished. Among these 39 patients, 32 were classified SGA-B (moderately malnourished) and 7 were classified SGA C (severely malnourished) mean global quality of life was 68.73 ± 19.05. Results from ANOVA test revealed that patients were statistically different across the Subjective Global Assessment groups according to global quality of life (p

Se describe el caso clínico de un paciente de 34 años de edad, quien presentaba múltiples schwannomas en el tercer ramo de bifurcación de la rama interna del nervio musculocutáneo, así como en los nervios colateral dorsal externo e interno del segundo y tercer dedos del pie derecho, respectivamente, atendido en el Servicio de Ortopedia del Hospital General Docente "Dr. Juan Bruno Zayas Alfonso de Santiago de Cuba. Se realizó la exéresis quirúrgica de 50 lesiones de diferentes tamaños aproximadamente. A los 45 días de operado habían desaparecido las molestias y pudo reincorporarse a sus actividades laborales habituales.

Se describe el caso clínico de un paciente de 61 años de edad, atendido en la consulta de Ortopedia y Traumatología del Hospital General Docente "Dr. Juan Bruno Zayas Alfonso" de Santiago de Cuba, por presentar aumento de volumen en el grueso artejo derecho desde hacía más de un año, con elevación y deformidad de la uña, lo cual dificultaba el uso del calzado. Se realizó la exéresis de la uña y de los 2 tercios distales de la falange distal del grueso artejo. Los resultados de los exámenes complementarios efectuados y la evaluación histológica informaron que se trataba de un tumor glómico sin evidencias de malignidad. A los 30 días habían desaparecido completamente las molestias, de manera que se incorporó a sus actividades laborales habituales.

Los angioleiomiomas son tumores benignos poco frecuentes en la mano. Tienen mayor incidencia a partir de la cuarta década de la vida, con igual distribución por sexo. Rara vez se realiza un diagnóstico preoperatorio correcto, pues suelen confundirse con gangliones y lipomas, entre otros. Se describen 11 casos clínicos tratados en el Centro de Diagnóstico Integral "Santa Bárbara de Zulia" en la República Bolivariana de Venezuela durante un trienio. Luego de la escisión simple la evolución fue favorable y no hubo recidiva.Angioleiomyomas are rare benign tumors of the hand. They have higher incidence from the fourth decade of life, with equal gender distribution. A correct preoperative diagnosis is rarely made, because they are usually mistaken for ganglions and lypomas, among others. Eleven clinical cases treated at "Santa Bárbara de Zulia" Comprehensive Diagnosis Center in the Bolivarian Republic of Venezuela during a triennium are described. After the simple excision, outcome was favorable and there were not relapses.

Se realizó un estudio descriptivo y transversal de 120 pacientes con úlceras del pie diabético, atendidos en el Centro de Diagnóstico Integral "El Bajo" perteneciente al municipio San Francisco, Maracaibo, Estado de Zulia, República Bolivariana de Venezuela, desde febrero de 2011 hasta igual mes de 2012, con vistas a evaluar la efectividad de la administración del factor de crecimiento epidérmico humano. En la casuística predominaron el grupo etario de 55-59 años y el sexo femenino. En todos los integrantes de la serie se logró la granulación y la cicatrización de las lesiones y no fue necesario efectuar la amputación. La administración intralesional del Heberprot-P® puede completar el cierre de la lesión, por lo cual es un medicamento seguro y conveniente para sanar dichas úlceras.A descriptive and cross-sectional study was conducted in 120 patients with diabetic foot ulcers treated at "El Bajo" Comprehensive Diagnosis Center belonging to San Francisco municipality, Maracaibo, State of Zulia, Bolivarian Republic of Venezuela, from February 2011 to February 2012 in order to evaluate the effectiveness of the administration of human epidermal growth factor. Age group of 55-59 years and the females prevailed in the case material. In all patients of the series granulation and healing of lesions was obtained and amputation was not necessary. Intralesional administration of Heberprot-P® can complete closure of the lesion; therefore it is a safe and advisable drug to heal these ulcers.

El presente trabajo forma parte de una propuesta de mejora acústica para construcciones ya realizadas, mediante el uso de un panel acústico hecho con materiales reciclados capaz de disminuir el sonido excedente, los materiales usados para la construcción del panel es cartón. Realizando tres casos diferentes pero en condiciones iguales, midiendo el sonido excedente que logra filtrarse a través de los muros propuestos sin la utilización del panel y con el panel colocado. Con esta información comparamos las diferencias que existen entre cada muro sin el panel, y después comparamos los resultados obtenidos que se midieron sin el panel y también con el panel para ver en qué medida logro disminuir el sonido excedente y también si es que se lograron los niveles de confort acústico. El presente trabajo forma parte de una propuesta de mejora acústica para construcciones ya realizadas, mediante el uso de un panel acústico hecho con materiales reciclados capaz de disminuir el sonido excedente, los materiales usados para la construcción del panel es cartón. Realizando tres casos diferentes pero en condiciones iguales, midiendo el sonido excedente que logra filtrarse a través de los muros propuestos sin la utilización del panel y con el panel colocado. Con esta información comparamos las diferencias que existen entre cada muro sin el panel, y después comparamos los resultados obtenidos que se midieron sin el panel y también con el panel para ver en qué medida logro disminuir el sonido excedente y también si es que se lograron los niveles de confort acústico.

Five tamarins (four Saguinus mystax and one S. labiatus) died with wasting syndrome characterized by chronic diarrhea at the Center for Reproduction and Conservation of Non-Human Primates in Iquitos, Peru. At necropsy, the terminal ileum of all affected tamarins was found to be markedly thickened. Histologically, the terminal ileal mucosa was completely ulcerated, and effaced by debris and mononuclear inflammatory cells. The submucosa and serosa were thickened by fibroplasia, mononuclear cell infiltrates and variable edema. No infectious agent was observed. The lesions were similar to those described previously for Crohn disease. This is to our knowledge the first report of terminal ileitis resembling Crohn disease in non-human primates.

One hundred and forty-three sakis (Pithecia), 107 bearded sakis (Chiropotes), and 7 red uakaris (Cacajao) were studied in relation to 18 genetic loci expressed on blood through electrophoretic techniques. Eight of the 18 loci showed intrapopulational variation. The low level of genetic diversity found inPithecia could be a consequence of a decrease in populational size due to intense habitat destruction. The genetic distances between the species investigated were:Pithecia ×Chiropotes: 0.49;Pithecia ×Cacajao: 0.57;Cacajao ×Chiropotes: 0.18–0.20. These results suggest, in accordance with other data, thatChiropotes andCacajao constitute a sister group within the pithecines.

An electrophoretic survey of 15 protein systems (22 loci) was employed to determine the genetic relationships among 9 populations (441 individuals) of South American squirrel monkeys (Saimiri sciureus sciureus, S. sciureus boliviensis, and S. sciureus ustus). Genetic markers capable of differentiating the second from the two other taxa were observed mainly in the ADA and GPI systems. Heterogeneity for ADA and CA2 between populations from opposite banks of the Jamari river was verified in S. sciureus ustus. The average heterozygosities ranged from 3% to 5%, the lowest being in S. sciureus sciureus and the highest in S. sciureus boliviensis. Low genetic distances (D = 0.001-0.057) were observed between populations within taxa or between S. sciureus sciureus and S. sciureus ustus. But both differed to a larger extent from S. sciureus boliviensis (D = 0.11 in both comparisons). There is a positive correlation between the genetic and geographic distance matrices. The three taxa are more clearly separated (D = 0.76-0.77) from the outgroup used for comparison (Cebus apella). Our data suggest that there is only one large, polytypic species of squirrel monkeys in South America, S. sciureus, forming a contiguous ring of geographical races or subspecies. Two of the most differentiated forms meet at the Peruvian Amazonia where natural hybrids and secondary intergradation have been reported. © 1993 Wiley-Liss, Inc.

Clinical and pathologic data were reviewed for 72 owl monkeys that died between January 1987 and May 1990 at the Center for Reproduction and Conservation of Nonhuman Primates in Iquitos, Peru. Tissue samples from 39 animals were examined. Hypertrophic cardiac disease (51% of animals examined), dilative cardiomyopathy (26%), and nephropathy (87%) were the most common diagnoses. The incidence of all three diseases appeared to increase with time in captivity. Nephropathy was less severe in colony-born animals.

From January 1987 to November 1990, 125 adult Saguinus mystax died at the CRCP. Enteritis/colitis (26%), hypoglycemia/cachexia (19%), and parasitic enteritis (13%) were the most common causes of death. Less common were purulent peritonitis (9%), lobular pneumonia (8%), and hemorrhagic gastroenterocolitis (6%). These results confirm the high frequency of gastroenteric lesions reported in Callitrichidae in captivity.

Four hundred and fifty wild-caught owl monkeys (Aotus nancymai) were shipped from Iquitos, Peru to Richland, Washington. Mortality and body weight changes from the time of shipment to 30 days after arrival were evaluated using age, sex, and transit time as comparison criteria. No association between mortality and sex, age, or transit time was observed. The mortality percentage from shipment to 30 days after arrival was 2.44%. Both age and transit time had a significant effect on weight changes, but sex did not. Shipping procedures are described.

The purpose of this study was to determine serum reference values for creatine kinase (CK), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) in captive-born and wild-caught owl monkeys to assess their usefulness for diagnosing myocardial disease.Blood samples were collected for CK, AST and LDH determinations. In addition, urine samples were collected and semiquantitative tests performed.There was no statistically significant difference between CK, AST and LDH when comparing both groups. However, when comparing monkeys with proteinuria to those without proteinuria, a statistically significant difference in CK value was observed (P = 0.021). In addition the CK/AST ratio revealed that 29% of the animals included in this study had values suggesting cardiac infarction. Grossly, cardiac concentric hypertrophy of the left ventricle and small, pitted kidneys were the most common findings. Microscopically, myocardial fibrosis, contraction band necrosis, hypertrophy and hyperplasia of coronary arteries, medium-sized renal arteries and afferent glomerular arteriolae were the most significant lesions, along with increased mesangial matrix and hypercellularity of glomeruli, Bowman's capsule and peritubular space fibroplasia.These findings suggest that CK, AST and LDH along with urinalysis provide a reliable method for diagnosing cardiomyopathies in the owl monkey. In addition, CK/AST ratio, proteinuria and the observed histological and ultrastructural changes suggest that Aotus vociferans suffer from arterial hypertension and chronic myocardial infarction.

There are few reports and poorly documented field studies about the reproductive biology of the owl monkey (Aotus spp.). Reproductive data were collected from a breeding colony of owl monkeys (Aotus nancymai) held at the Center for Reproduction and Conservation of Non-Human Primates in Iquitos, Peru, for the past 10 years. Seventy nine breeding pairs have produced 180 offspring in a period of 3,619 months, representing an average of about one offspring for every 20 months that a pair was housed together. Neonatal mortality in the first week was 7.1%. Litter size was almost one (99.4%). The mean age at first birth in a group of nine females born in captivity was 40.56 ± 7.82 (S.D.) months. The mean age of a group of 12 males born in the colony when their female mates produced offspring was 42.17 ± 10.73 (S.D.) months. Gestation length did not exceed 141 days. Interbirth interval averaged 12.72 months. A birth peak was observed from October to January. Breeding Aotus nancymai on a large scale in captivity is feasible.

The objective of this study was to establish reference serum values for bilirrubin (total and direct), alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase, cholesterol, total protein, albumin, urea, and creatinine in healthy collared peccary (Tayassu tajacu) kept under captivity in the Amazonian jungle of Peru (Loreto, Iquitos). A total of 28 adult animals (14 males and 14 females) were used. Blood samples (7 ml) were collected from the safen vein. Serum values were: Total bilirrubin: 0.7 ± 0.2 mg/dl; direct bilirrubin: 0.2 ± 0.1 mg/dl; ALT: 26.5 ± 9.1 UI/l; AST: 15.9 ± 8.4 UI/l; alkaline phosphatase: 27.5 ± 15.5 UI/l; cholesterol: 94.4 ± 20.2 mg/dl; total protein: 8.5 ± 1.1 g/dl; albumin: 4.4 ± 0.5 g/dl; urea: 58.1 ± 11.1 mg/dl; and creatinine: 2.2 ± 0.5 mg/dl. It was concluded that serum values were similar to other results reported in the literature and without statistical differences due to sex. The objective of this study was to establish reference serum values for bilirrubin (total and direct), alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase, cholesterol, total protein, albumin, urea, and creatinine in healthy collared peccary (Tayassu tajacu) kept under captivity in the Amazonian jungle of Peru (Loreto, Iquitos). A total of 28 adult animals (14 males and 14 females) were used. Blood samples (7 ml) were collected from the safen vein. Serum values were: Total bilirrubin: 0.7 ± 0.2 mg/dl; direct bilirrubin: 0.2 ± 0.1 mg/dl; ALT: 26.5 ± 9.1 UI/l; AST: 15.9 ± 8.4 UI/l; alkaline phosphatase: 27.5 ± 15.5 UI/l; cholesterol: 94.4 ± 20.2 mg/dl; total protein: 8.5 ± 1.1 g/dl; albumin: 4.4 ± 0.5 g/dl; urea: 58.1 ± 11.1 mg/dl; and creatinine: 2.2 ± 0.5 mg/dl. It was concluded that serum values were similar to other results reported in the literature and without statistical differences due to sex.

A survey for helminth parasites in feral New World non-human primates was conducted and compared with parasitological data from man in the region. A total of 835 fecal samples were collected from feral Aotus nancymae, A. vociferans, Saguinus labiatus, S. mystax, Saimiri boliviensis peruviensis, S. sciureus macrodon, Lagothrix lagotricha and Cacajao calvus rubicundus. In addition, adult parasites were collected from necropsies performed on monkeys that died during quarantine and in captivity. Helminth parasites shared by non-human primates and man in Peru were Ancylostoma braziliensis and Ascaris lumbricoides, found in a captive L. lagotricha; Necator americanus, found in a captive C. calvus rubicundus; Hymenolepis diminuta, found in feral Aotus spp. and S. mystax; and a single Trichuris spp. specimen found in a feral S. sciureus macrodon.

El presente estudio tuvo por objetivo determinar los valores hematologicos en ronsocos (Hydrochaeris hydrochaeris) de la Amazonia Peruana en condiciones climaticas normales, bajo un particular sistema de manejo en cautiverio. Se emplearon ronsocos machos (n=19) y hembras (n=16), entre juveniles y adultos, provinientes del zoocriadero "Biodiversidad Amazonica (BIOAM)", ubicado en la ciudad de Iquitos, departamento de Loreto-Peru. Para la obtencion de muestras, los animales fueron anastesiados con xilazina en una dosis de 0.25 a 0.5 mg/kpv y kentamina en dosis de 7-10 mg/kpv cargados en dardos. la sangre fue colectada en tubos conteniendo EDTA (etilenodiaminotetraacetico). el numero de eritrocitos y leucositos fueron determinados por el metodo convencional con camara de Neubauer, el hematocrito por el metodo del microhematocrito, la hemoglobina por el metodo de oxihemoglobina el recuento diferencial de leucocitos utilizando la tecnica de Shilling y se calcularon los indices hematemetricos (VGM, HGM y CMHG) en base a los valores hematologicos encontrados para la serie roja. analisis estadistico se realizo utilizando la prueba de T Student. Los resultados fueron para la serie eritrocitica: 3.19±0.157x 10.6 ul; hemoglobina 14.32±0.16 g/ml; hematrocrito: 42.23±1.52%; VGM: 133.53±5.92 fl; H.G.M.:45.57±2.28Pg; C.H.G.M.: 34.42±2.20 g/dl; y en la serie leucocitica: 5.40±0.31 x 10.3/μL; neutrofilos en banda: 0.94±0.31%; segmentados: 51.89±3.06%; eosinofilos: 1.57±0.59%; basofilos 0%; linfocitos: 42.26±3.21%. No se encontraron mielocitos, metamielocitos ni monocitos. Tampoco se encontraron diferencias estadisticas significativas entre machos y hembras.

A wild-caught male Aotus vociferans died spontaneously during quarantine. Histologic examination of the heart showed several small myocardial arteries replaced with fibrinoid necrosis and adjacent inflammation that included lymphocytes and large histiocytic cells. Less often, similar inflammatory foci were observed in the myocardium interstitium. The lesions observed in the heart of the owl monkey resembled Aschoff bodies.

Se reportan los valores hematológicos de pecaríes peruanos Tuyussu tujacu. Las muestras de sangre fueron tomadas de 11 animales en el Zoológico Parque de las Leyendas de Lima, 7 en la Biodiversidad Amazónica (BIOAM) centro de cría en Iquitos y 4 en el Centro Piloto para Crianza del Majaz (Universidad Nacional de la Amazonía Peruana) también en Iquitos. Después de la sedación con Ketamina (12 mg/kg) usando una jeringa en tubo o cervatana, las muestras de sangre se recogieron de la vena cefálica en tubos estériles que contienen EDTA y frotis de sangre realizadas. Los análisis hematológicos se llevaron a cabo en el Laboratorio de Patología Clínica, Facultad de Medicina Veterinaria de la Universidad de San Marcos, en Lima, dando los siguientes resultados para los pecaríes de Lima e Iquitos respectivamente: Hb (g/dl) 15,48±1,60, 11,26±0,98; Ht(%) 35,09±4,41, 32,64±5,35; eritrocitos(x10^6/ul) 6,036±1,58, 3,30±0,99; Ieucocitos (x10^3/ul) 13,77±4,85, 15,29±6,69; cayados(%) 1,33±0,58, 1,6±0,55; neutrófilos segmentados (%) 48,27±7,2, 23,64±12,51; linfocitos (%) 50,64±6,96 , 69,09±11,23; eosinófilos (%) 1,33±0,52, 6,09±3,24; monocitos (%) 0,1; basófilos (%) 0,1; plaquetas (trombocitos/ml) 338.220±221.760 y 167.490±54.390. Los valores hematológicos de los pecaríes en Lima son similares a los publicados para los animales de América del Norte, pero se diferencian de los resultados de Iquitos, que contenía un alto porcentaje de linfocitos y eosinófilos que reflejan la anemia.

Un estudio biométrico en Aotus nancymae, (mono búho) se realizó en el IVITA- lquitos, Perú con la finalidad de medir parámetros de crecimiento durante el primer semestre de vida en ejemplares nacidos en cautiverio. Se registraron medidas biométricas en 30 neonatos de mono búho desde el nacimiento hasta las 26 semanas de vida con intervalos de 2 semanas. Las medidas biométricas consideradas fueron peso corporal, largo corporal, longitud de brazo, pierna y cola, y perímetro craneano. Se concluyó que las mediadas biométricas registradas están perfectamente correlacionadas con la edad. La ecuación de regresión lineal múltiple (Y= a+b1x1 + b2x2 + b3x3 + b4x4 + b5x5 + b6x6 ) nos permite predecir la edad de un Aotus hasta el año de edad a partir de los valores biométricos obtenidos.

Two captive-born Saddleback tamarins (Saguinus fuscicollis) died unexpectedly in the primate colony at the Peruvian Primatological Project. At necropsy, a firm, mobile, oblong, obscure mass was discovered in the stomach of each. They were removed and determined to be trichobezoars.

e20696 Background: Cancer-related symptoms are less investigated but frequently reported patient-experienced symptom clusters. In palliative oncology, focus is on recognizing and addressing these symptoms, and giving quality of life. The purpose of this study is to determine the severity of cancer related symptoms among metastatic cancer patients on palliative chemotherapy using the MD Anderson Symptom Inventory (Filipino) [MDASI-F]. Methods: A cross-sectional study among metastatic cancer patients undergoing palliative chemotherapy at the National Kidney and Transplant Institute, Philippines, was performed using MDASI-F. Results: A total of 114 patients were included with a mean age of 55.5 years. 61% were female, and 39% were male. 81.6% were married, while 14% were single and 4.4% were widowed. Highest educational level attained were college (78.1%), high school (19.3%) and primary school (2.6%). Average Body Mass Index fall on 23 kg/m2. Majority of the patients have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 1 (54.4%), followed by ECOG 2 (19.3%), ECOG 0 (18.4%), and ECOG 3 (7.9%). The most common cancer site is breast (30.7%), followed by colon (21.9%), and lungs (16.7%), while the remaining 30.7% belong to other cancer sites. Majority of the patients have one metastatic site (68.4%), 22.8% have two, while 8.8% have 3 metastatic sites. Mean duration of illness from the time of diagnosis was 13.67 months. The most severe cancer related symptoms were sleep disturbance (mean 3.48), fatigue (mean 3.36) and pain (mean 3.14). Interestingly, all Filipino metastatic cancer related severity symptoms and interference items belong to the mild severity score (scores of 0-3) using the MDSAI-F. Conclusions: Among Filipino metastatic cancer patients on palliative chemotherapy, cancer-related symptom severity items and interference items were shown to have mild severity scores based on the MDASI-F.