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2 results on '"Epi64C"'

1. The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia.

Author

Villagomez, Fabian R., Medina-Contreras, Oscar, Cerna-Cortes, Jorge Francisco, and Patino-Lopez, Genaro

Subjects
*LEUKEMIA, *CANCER, *METASTASIS, *ONCOGENES
Abstract

The study of cancer has allowed researchers to describe some biological characteristics that tumor cells acquire during their development, known as the "hallmarks of cancer" but more research is needed to expand our knowledge about cancer biology and to generate new strategies of treatment. The role that RabGTPases might play in some hallmarks of cancer represents interesting areas of study since these proteins are frequently altered in cancer. However, their participation is not well known. Recently, Rab35was recognized as an oncogenic RabGTPase and and because of its association with different cellular functions, distinctly important in immune cells, a possible role of Rab35 in leukemia can be suggested. Nevertheless, the involvement of Rab35 in cancer remains poorly understood and its possible specific role in leukemia remains unknown. In this review, we analyze general aspects of the participation of RabGTPases in cancer, and especially, the plausible role of Rab35 in leukemia. [ABSTRACT FROM AUTHOR]

Published
2020
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2. The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia

Author

Oscar Medina-Contreras, Jorge F. Cerna-Cortes, Genaro Patino-Lopez, and Fabian R. Villagomez

Subjects
RAC1, CDC42, Review, exosomes, Biology, Biochemistry, Metastasis, actin dynamics, 03 medical and health sciences, 0302 clinical medicine, Immune system, medicine, Humans, metastasis, Cdc42, Arf6, 030304 developmental biology, immune evasion, Epi64C, 0303 health sciences, Leukemia, Cancer, Cell Biology, medicine.disease, Evasion (ethics), Microvesicles, Cell biology, RabGTPases, Rab35, rab GTP-Binding Proteins, 030220 oncology & carcinogenesis, Cancer research, cancer invasion, vesicular trafficking, Rac1
Abstract

The study of cancer has allowed researchers to describe some biological characteristics that tumor cells acquire during their development, known as the “hallmarks of cancer” but more research is needed to expand our knowledge about cancer biology and to generate new strategies of treatment. The role that RabGTPases might play in some hallmarks of cancer represents interesting areas of study since these proteins are frequently altered in cancer. However, their participation is not well known. Recently, Rab35was recognized as an oncogenic RabGTPase and and because of its association with different cellular functions, distinctly important in immune cells, a possible role of Rab35 in leukemia can be suggested. Nevertheless, the involvement of Rab35 in cancer remains poorly understood and its possible specific role in leukemia remains unknown. In this review, we analyze general aspects of the participation of RabGTPases in cancer, and especially, the plausible role of Rab35 in leukemia.

Published
2018

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