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1. Demonstration of the release of an epithelium-derived inhibitory factor from a novel preparation of guinea-pig trachea

Author

R. M. Muccitelli, Douglas W. P. Hay, David Raeburn, Karen A. Wilson, and Derek L. Horstemeyer

Subjects
Pharmacology, Male, Epithelium-derived inhibitory factor, Ovalbumin, Airway Resistance, Guinea Pigs, respiratory system, Biology, In Vitro Techniques, Inhibitory postsynaptic potential, Epithelium, Airway hyperreactivity, Cell biology, Guinea pig, Trachea, medicine.anatomical_structure, Antigen, Immunology, medicine, biology.protein, Respiratory Hypersensitivity, Animals, Respiratory tract
Abstract

Using a novel preparation of guinea-pig trachea, direct evidence was obtained for the release of an epithelium-derived inhibitory factor modulating contractions elicited by antigen. Thus, epithelium removal produced a 6.1-fold leftward shift in ovalbumin concentration-response curves in tracheal strips from ovalbumin-sensitized guinea-pigs. This increase in sensitivity to ovalbumin was not evident when a tracheal portion containing epithelium was positioned in close proximity to the tissue from which tension was recorded.

Published
1987

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